 Photosensitizing Agents
"Photosensitizing Agents" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Drugs that are pharmacologically inactive but when exposed to ultraviolet radiation or sunlight are converted to their active metabolite to produce a beneficial reaction affecting the diseased tissue. These compounds can be administered topically or systemically and have been used therapeutically to treat psoriasis and various types of neoplasms.
| Descriptor ID |
D017319
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| MeSH Number(s) |
D27.505.954.444.600 D27.505.954.600.710
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| Concept/Terms |
Photosensitizing Effect- Photosensitizing Effect
- Effect, Photosensitizing
- Photosensitizing Effects
- Effects, Photosensitizing
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Below are MeSH descriptors whose meaning is more general than "Photosensitizing Agents".
Below are MeSH descriptors whose meaning is more specific than "Photosensitizing Agents".
This graph shows the total number of publications written about "Photosensitizing Agents" by people in UAMS Profiles by year, and whether "Photosensitizing Agents" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2024 | 0 | 1 | 1 | | 2023 | 0 | 1 | 1 | | 2022 | 0 | 1 | 1 | | 2020 | 1 | 0 | 1 | | 2018 | 2 | 1 | 3 | | 2017 | 1 | 0 | 1 | | 2016 | 0 | 1 | 1 | | 2015 | 3 | 1 | 4 | | 2014 | 1 | 0 | 1 | | 2013 | 1 | 0 | 1 | | 2011 | 1 | 0 | 1 | | 2001 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Photosensitizing Agents" by people in Profiles over the past ten years.
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Nguyen A, Bhandari C, Keown M, Malkoochi A, Quaye M, Mahmoud D, Shah N, Alzhanova D, Cameron CG, Ferruzzi J, McFarland SA, Shafirstein G, Brekken R, Obaid G. Increasing the Dye Payload of Cetuximab-IRDye800CW Enables Photodynamic Therapy. Mol Pharm. 2024 Jul 01; 21(7):3296-3309.
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Forson M, Bashiru M, Macchi S, Singh S, Anderson AD, Sayyed S, Ishtiaq A, Griffin R, Ali N, Oyelere AK, Berry B, Siraj N. Cationic Porphyrin-Based Ionic Nanomedicines for Improved Photodynamic Therapy. ACS Appl Bio Mater. 2023 12 18; 6(12):5662-5675.
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Kim EJ, Mangold AR, DeSimone JA, Wong HK, Seminario-Vidal L, Guitart J, Appel J, Geskin L, Lain E, Korman NJ, Zeitouni N, Nikbakht N, Dawes K, Akilov O, Carter J, Shinohara M, Kuzel TM, Piette W, Bhatia N, Musiek A, Pariser D, Kim YH, Elston D, Boh E, Duvic M, Huen A, Pacheco T, Zwerner JP, Lee ST, Girardi M, Querfeld C, Bohjanen K, Olsen E, Wood GS, Rumage A, Donini O, Haulenbeek A, Schaber CJ, Straube R, Pullion C, Rook AH, Poligone B. Efficacy and Safety of Topical Hypericin Photodynamic Therapy for Early-Stage Cutaneous T-Cell Lymphoma (Mycosis Fungoides): The FLASH Phase 3 Randomized Clinical Trial. JAMA Dermatol. 2022 09 01; 158(9):1031-1039.
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Shafirstein G, Oakley E, Hamilton S, Habitzruther M, Chamberlain S, Sexton S, Curtin L, Bellnier DA. In Vivo Models for Studying Interstitial Photodynamic Therapy of Locally Advanced Cancer. Methods Mol Biol. 2022; 2451:151-162.
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Oakley E, Bellnier D, Hutson A, Cooper H, Habitzruther M, Sexton S, Curtin L, Tworek L, Mallory M, Henderson B, Shafirstein G. Irradiance, Photofrin? Dose and Initial Tumor Volume are Key Predictors of Response to Interstitial Photodynamic Therapy of Locally Advanced Cancers in Translational Models. Photochem Photobiol. 2020 03; 96(2):397-404.
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Li Q, Li Y, Min T, Gong J, Du L, Phillips DL, Liu J, Lam JWY, Sung HHY, Williams ID, Kwok RTK, Ho CL, Li K, Wang J, Tang BZ. Time-Dependent Photodynamic Therapy for Multiple Targets: A Highly Efficient AIE-Active Photosensitizer for Selective Bacterial Elimination and Cancer Cell Ablation. Angew Chem Int Ed Engl. 2020 06 08; 59(24):9470-9477.
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Shafirstein G, Bellnier DA, Oakley E, Hamilton S, Habitzruther M, Tworek L, Hutson A, Spernyak JA, Sexton S, Curtin L, Turowski SG, Arshad H, Henderson B. Irradiance controls photodynamic efficacy and tissue heating in experimental tumours: implication for interstitial PDT of locally advanced cancer. Br J Cancer. 2018 11; 119(10):1191-1199.
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Alkarakooly Z, Al-Anbaky QA, Kannan K, Ali N. Metabolic reprogramming by Dichloroacetic acid potentiates photodynamic therapy of human breast adenocarcinoma MCF-7 cells. PLoS One. 2018; 13(10):e0206182.
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Mudambi S, Pera P, Washington D, Remenyik E, Fidrus E, Shafirstein G, Bellnier D, Paragh G. Photodynamic therapy does not induce cyclobutane pyrimidine dimers in the presence of melanin. Photodiagnosis Photodyn Ther. 2018 Jun; 22:241-244.
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Oakley E, Bellnier DA, Hutson A, Wrazen B, Arshad H, Quon H, Shafirstein G. Surface markers for guiding cylindrical diffuser fiber insertion in interstitial photodynamic therapy of head and neck cancer. Lasers Surg Med. 2017 08; 49(6):599-608.
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Rohrbach DJ, Rigual N, Arshad H, Tracy EC, Cooper MT, Shafirstein G, Wilding G, Merzianu M, Baumann H, Henderson BW, Sunar U. Intraoperative optical assessment of photodynamic therapy response of superficial oral squamous cell carcinoma. J Biomed Opt. 2016 Jan; 21(1):18002.
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Jenkins SV, Srivatsan A, Reynolds KY, Gao F, Zhang Y, Heyes CD, Pandey RK, Chen J. Understanding the interactions between porphyrin-containing photosensitizers and polymer-coated nanoparticles in model biological environments. J Colloid Interface Sci. 2016 Jan 01; 461:225-231.
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Shafirstein G, Rigual NR, Arshad H, Cooper MT, Bellnier DA, Wilding G, Tan W, Merzianu M, Henderson BW. Photodynamic therapy with 3-(1'-hexyloxyethyl) pyropheophorbide-a for early-stage cancer of the larynx: Phase Ib study. Head Neck. 2016 04; 38 Suppl 1:E377-83.
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Paithankar DY, Sakamoto FH, Farinelli WA, Kositratna G, Blomgren RD, Meyer TJ, Faupel LJ, Kauvar ANB, Lloyd JR, Cheung WL, Owczarek WD, Suwalska AM, Kochanska KB, Nawrocka AK, Paluchowska EB, Podolec KM, Pirowska MM, Wojas-Pelc AB, Anderson RR. Acne Treatment Based on Selective Photothermolysis of Sebaceous Follicles with Topically Delivered Light-Absorbing Gold Microparticles. J Invest Dermatol. 2015 Jul; 135(7):1727-1734.
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Oakley E, Wrazen B, Bellnier DA, Syed Y, Arshad H, Shafirstein G. A new finite element approach for near real-time simulation of light propagation in locally advanced head and neck tumors. Lasers Surg Med. 2015 Jan; 47(1):60-7.
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