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Co-Authors

This is a "connection" page, showing publications co-authored by Praveen Juvvadi and William Steinbach.

 
Connection Strength
  
 
 
14.654
  
  1. Juvvadi PR, Bobay BG, Cole DC, Awwa M, Steinbach WJ. Calcineurin Inhibitor CN585 Exhibits Off-Target Effects in the Human Fungal Pathogen Aspergillus fumigatus. J Fungi (Basel). 2022 Dec 07; 8(12).
    View in: PubMed
    Score: 0.875
  2. Juvvadi PR, Bobay BG, Gobeil SMC, Cole DC, Venters RA, Heitman J, Spicer LD, Steinbach WJ. FKBP12 dimerization mutations effect FK506 binding and differentially alter calcineurin inhibition in the human pathogen Aspergillus fumigatus. Biochem Biophys Res Commun. 2020 05 21; 526(1):48-54.
    View in: PubMed
    Score: 0.724
  3. Juvvadi PR, Fox D, Bobay BG, Hoy MJ, Gobeil SMC, Venters RA, Chang Z, Lin JJ, Averette AF, Cole DC, Barrington BC, Wheaton JD, Ciofani M, Trzoss M, Li X, Lee SC, Chen YL, Mutz M, Spicer LD, Schumacher MA, Heitman J, Steinbach WJ. Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents. Nat Commun. 2019 09 19; 10(1):4275.
    View in: PubMed
    Score: 0.700
  4. Juvvadi PR, Cole DC, Falloon K, Waitt G, Soderblom EJ, Moseley MA, Steinbach WJ. Kin1 kinase localizes at the hyphal septum and is dephosphorylated by calcineurin but is dispensable for septation and virulence in the human pathogen Aspergillus fumigatus. Biochem Biophys Res Commun. 2018 11 02; 505(3):740-746.
    View in: PubMed
    Score: 0.655
  5. Juvvadi PR, Moseley MA, Hughes CJ, Soderblom EJ, Lennon S, Perkins SR, Thompson JW, Geromanos SJ, Wildgoose J, Richardson K, Langridge JI, Vissers JPC, Steinbach WJ. Scanning Quadrupole Data-Independent Acquisition, Part B: Application to the Analysis of the Calcineurin-Interacting Proteins during Treatment of Aspergillus fumigatus with Azole and Echinocandin Antifungal Drugs. J Proteome Res. 2018 02 02; 17(2):780-793.
    View in: PubMed
    Score: 0.621
  6. Juvvadi PR, Lee SC, Heitman J, Steinbach WJ. Calcineurin in fungal virulence and drug resistance: Prospects for harnessing targeted inhibition of calcineurin for an antifungal therapeutic approach. Virulence. 2017 02 17; 8(2):186-197.
    View in: PubMed
    Score: 0.559
  7. Juvvadi PR, Pemble CW, Ma Y, Steinbach WJ. Novel motif in calcineurin catalytic subunit is required for septal localization of calcineurin in Aspergillus fumigatus. FEBS Lett. 2016 Feb; 590(4):501-8.
    View in: PubMed
    Score: 0.546
  8. Juvvadi PR, Steinbach WJ. Calcineurin Orchestrates Hyphal Growth, Septation, Drug Resistance and Pathogenesis of Aspergillus fumigatus: Where Do We Go from Here? Pathogens. 2015 Dec 16; 4(4):883-93.
    View in: PubMed
    Score: 0.539
  9. Steinbach WJ, Lamoth F, Juvvadi PR. Potential Microbiological Effects of Higher Dosing of Echinocandins. Clin Infect Dis. 2015 Dec 01; 61 Suppl 6:S669-77.
    View in: PubMed
    Score: 0.538
  10. Juvvadi PR, Mu?oz A, Lamoth F, Soderblom EJ, Moseley MA, Read ND, Steinbach WJ. Calcium-Mediated Induction of Paradoxical Growth following Caspofungin Treatment Is Associated with Calcineurin Activation and Phosphorylation in Aspergillus fumigatus. Antimicrob Agents Chemother. 2015 Aug; 59(8):4946-55.
    View in: PubMed
    Score: 0.520
  11. Juvvadi PR, Ma Y, Richards AD, Soderblom EJ, Moseley MA, Lamoth F, Steinbach WJ. Identification and mutational analyses of phosphorylation sites of the calcineurin-binding protein CbpA and the identification of domains required for calcineurin binding in Aspergillus fumigatus. Front Microbiol. 2015; 6:175.
    View in: PubMed
    Score: 0.512
  12. Juvvadi PR, Lamoth F, Steinbach WJ. Calcineurin as a Multifunctional Regulator: Unraveling Novel Functions in Fungal Stress Responses, Hyphal Growth, Drug Resistance, and Pathogenesis. Fungal Biol Rev. 2014 Oct; 28(2-3):56-69.
    View in: PubMed
    Score: 0.496
  13. Juvvadi PR, Lamoth F, Steinbach WJ. Calcineurin-mediated regulation of hyphal growth, septation, and virulence in Aspergillus fumigatus. Mycopathologia. 2014 Dec; 178(5-6):341-8.
    View in: PubMed
    Score: 0.492
  14. Juvvadi PR, Gehrke C, Fortwendel JR, Lamoth F, Soderblom EJ, Cook EC, Hast MA, Asfaw YG, Moseley MA, Creamer TP, Steinbach WJ. Phosphorylation of Calcineurin at a novel serine-proline rich region orchestrates hyphal growth and virulence in Aspergillus fumigatus. PLoS Pathog. 2013; 9(8):e1003564.
    View in: PubMed
    Score: 0.459
  15. Juvvadi PR, Belina D, Soderblom EJ, Moseley MA, Steinbach WJ. Filamentous fungal-specific septin AspE is phosphorylated in vivo and interacts with actin, tubulin and other septins in the human pathogen Aspergillus fumigatus. Biochem Biophys Res Commun. 2013 Feb 15; 431(3):547-53.
    View in: PubMed
    Score: 0.440
  16. Juvvadi PR, Fortwendel JR, Rogg LE, Burns KA, Randell SH, Steinbach WJ. Localization and activity of the calcineurin catalytic and regulatory subunit complex at the septum is essential for hyphal elongation and proper septation in Aspergillus fumigatus. Mol Microbiol. 2011 Dec; 82(5):1235-59.
    View in: PubMed
    Score: 0.406
  17. Juvvadi PR, Fortwendel JR, Rogg LE, Steinbach WJ. Differential localization patterns of septins during growth of the human fungal pathogen Aspergillus fumigatus reveal novel functions. Biochem Biophys Res Commun. 2011 Feb 11; 405(2):238-43.
    View in: PubMed
    Score: 0.383
  18. Juvvadi PR, Fortwendel JR, Pinchai N, Perfect BZ, Heitman J, Steinbach WJ. Calcineurin localizes to the hyphal septum in Aspergillus fumigatus: implications for septum formation and conidiophore development. Eukaryot Cell. 2008 Sep; 7(9):1606-10.
    View in: PubMed
    Score: 0.322
  19. Shwab EK, Juvvadi PR, Shaheen SK, Allen J, Waitt G, Soderblom EJ, Asfaw YG, Moseley MA, Steinbach WJ. Protein Kinase A Regulates Autophagy-Associated Proteins Impacting Growth and Virulence of Aspergillus fumigatus. J Fungi (Basel). 2022 Mar 30; 8(4).
    View in: PubMed
    Score: 0.208
  20. Shaheen SK, Juvvadi PR, Allen J, Shwab EK, Cole DC, Asfaw YG, Kapoor M, Shaw KJ, Steinbach WJ. In Vitro Activity of APX2041, a New Gwt1 Inhibitor, and In Vivo Efficacy of the Prodrug APX2104 against Aspergillus fumigatus. Antimicrob Agents Chemother. 2021 09 17; 65(10):e0068221.
    View in: PubMed
    Score: 0.199
  21. Shwab EK, Juvvadi PR, Waitt G, Shaheen S, Allen J, Soderblom EJ, Bobay BG, Asfaw YG, Moseley MA, Steinbach WJ. The Protein Kinase A-Dependent Phosphoproteome of the Human Pathogen Aspergillus fumigatus Reveals Diverse Virulence-Associated Kinase Targets. mBio. 2020 12 15; 11(6).
    View in: PubMed
    Score: 0.191
  22. Roundtree MT, Juvvadi PR, Shwab EK, Cole DC, Steinbach WJ. Aspergillus fumigatus Cyp51A and Cyp51B Proteins Are Compensatory in Function and Localize Differentially in Response to Antifungals and Cell Wall Inhibitors. Antimicrob Agents Chemother. 2020 09 21; 64(10).
    View in: PubMed
    Score: 0.188
  23. Renshaw H, Juvvadi PR, Cole DC, Steinbach WJ. The class V myosin interactome of the human pathogen Aspergillus fumigatus reveals novel interactions with COPII vesicle transport proteins. Biochem Biophys Res Commun. 2020 06 18; 527(1):232-237.
    View in: PubMed
    Score: 0.183
  24. Shwab EK, Juvvadi PR, Waitt G, Soderblom EJ, Barrington BC, Asfaw YG, Moseley MA, Steinbach WJ. Calcineurin-dependent dephosphorylation of the transcription factor CrzA at specific sites controls conidiation, stress tolerance, and virulence of Aspergillus fumigatus. Mol Microbiol. 2019 07; 112(1):62-80.
    View in: PubMed
    Score: 0.170
  25. Renshaw H, Vargas-Mu?iz JM, Juvvadi PR, Richards AD, Waitt G, Soderblom EJ, Moseley MA, Steinbach WJ. The tail domain of the Aspergillus fumigatus class V myosin MyoE orchestrates septal localization and hyphal growth. J Cell Sci. 2018 02 07; 131(3).
    View in: PubMed
    Score: 0.156
  26. Shwab EK, Juvvadi PR, Waitt G, Soderblom EJ, Moseley MA, Nicely NI, Steinbach WJ. Phosphorylation of Aspergillus fumigatus PkaR impacts growth and cell wall integrity through novel mechanisms. FEBS Lett. 2017 11; 591(22):3730-3744.
    View in: PubMed
    Score: 0.154
  27. Vargas-Mu?iz JM, Renshaw H, Waitt G, Soderblom EJ, Moseley MA, Palmer JM, Juvvadi PR, Keller NP, Steinbach WJ. Caspofungin exposure alters the core septin AspB interactome of Aspergillus fumigatus. Biochem Biophys Res Commun. 2017 04 01; 485(2):221-226.
    View in: PubMed
    Score: 0.146
  28. Shwab EK, Juvvadi PR, Waitt G, Soderblom EJ, Moseley MA, Nicely NI, Asfaw YG, Steinbach WJ. A Novel Phosphoregulatory Switch Controls the Activity and Function of the Major Catalytic Subunit of Protein Kinase A in Aspergillus fumigatus. mBio. 2017 02 07; 8(1).
    View in: PubMed
    Score: 0.146
  29. Vargas-Mu?iz JM, Juvvadi PR, Steinbach WJ. Forging the ring: from fungal septins' divergent roles in morphology, septation and virulence to factors contributing to their assembly into higher order structures. Microbiology (Reading). 2016 09; 162(9):1527-1534.
    View in: PubMed
    Score: 0.141
  30. Vargas-Mu?iz JM, Renshaw H, Richards AD, Waitt G, Soderblom EJ, Moseley MA, Asfaw Y, Juvvadi PR, Steinbach WJ. Dephosphorylation of the Core Septin, AspB, in a Protein Phosphatase 2A-Dependent Manner Impacts Its Localization and Function in the Fungal Pathogen Aspergillus fumigatus. Front Microbiol. 2016; 7:997.
    View in: PubMed
    Score: 0.140
  31. Renshaw H, Vargas-Mu?iz JM, Richards AD, Asfaw YG, Juvvadi PR, Steinbach WJ. Distinct Roles of Myosins in Aspergillus fumigatus Hyphal Growth and Pathogenesis. Infect Immun. 2016 05; 84(5):1556-64.
    View in: PubMed
    Score: 0.138
  32. Lamoth F, Juvvadi PR, Steinbach WJ. Editorial: Advances in Aspergillus fumigatus Pathobiology. Front Microbiol. 2016; 7:43.
    View in: PubMed
    Score: 0.136
  33. Falloon K, Juvvadi PR, Richards AD, Vargas-Mu?iz JM, Renshaw H, Steinbach WJ. Characterization of the FKBP12-Encoding Genes in Aspergillus fumigatus. PLoS One. 2015; 10(9):e0137869.
    View in: PubMed
    Score: 0.132
  34. Vargas-Mu?iz JM, Renshaw H, Richards AD, Lamoth F, Soderblom EJ, Moseley MA, Juvvadi PR, Steinbach WJ. The Aspergillus fumigatus septins play pleiotropic roles in septation, conidiation, and cell wall stress, but are dispensable for virulence. Fungal Genet Biol. 2015 Aug; 81:41-51.
    View in: PubMed
    Score: 0.130
  35. Lamoth F, Juvvadi PR, Soderblom EJ, Moseley MA, Steinbach WJ. Hsp70 and the Cochaperone StiA (Hop) Orchestrate Hsp90-Mediated Caspofungin Tolerance in Aspergillus fumigatus. Antimicrob Agents Chemother. 2015 Aug; 59(8):4727-33.
    View in: PubMed
    Score: 0.130
  36. Lamoth F, Juvvadi PR, Steinbach WJ. Histone deacetylase inhibition as an alternative strategy against invasive aspergillosis. Front Microbiol. 2015; 6:96.
    View in: PubMed
    Score: 0.127
  37. Lamoth F, Alexander BD, Juvvadi PR, Steinbach WJ. Antifungal activity of compounds targeting the Hsp90-calcineurin pathway against various mould species. J Antimicrob Chemother. 2015 May; 70(5):1408-11.
    View in: PubMed
    Score: 0.126
  38. Sugui JA, Kwon-Chung KJ, Juvvadi PR, Latg? JP, Steinbach WJ. Aspergillus fumigatus and related species. Cold Spring Harb Perspect Med. 2014 Nov 06; 5(2):a019786.
    View in: PubMed
    Score: 0.125
  39. Lamoth F, Juvvadi PR, Steinbach WJ. Heat shock protein 90 (Hsp90): A novel antifungal target against Aspergillus fumigatus. Crit Rev Microbiol. 2016; 42(2):310-21.
    View in: PubMed
    Score: 0.124
  40. Lamoth F, Juvvadi PR, Soderblom EJ, Moseley MA, Asfaw YG, Steinbach WJ. Identification of a key lysine residue in heat shock protein 90 required for azole and echinocandin resistance in Aspergillus fumigatus. Antimicrob Agents Chemother. 2014; 58(4):1889-96.
    View in: PubMed
    Score: 0.118
  41. Lamoth F, Juvvadi PR, Gehrke C, Asfaw YG, Steinbach WJ. Transcriptional activation of heat shock protein 90 mediated via a proximal promoter region as trigger of caspofungin resistance in Aspergillus fumigatus. J Infect Dis. 2014 Feb 01; 209(3):473-81.
    View in: PubMed
    Score: 0.116
  42. Lamoth F, Juvvadi PR, Gehrke C, Steinbach WJ. In vitro activity of calcineurin and heat shock protein 90 Inhibitors against Aspergillus fumigatus azole- and echinocandin-resistant strains. Antimicrob Agents Chemother. 2013 Feb; 57(2):1035-9.
    View in: PubMed
    Score: 0.109
  43. Lamoth F, Juvvadi PR, Fortwendel JR, Steinbach WJ. Heat shock protein 90 is required for conidiation and cell wall integrity in Aspergillus fumigatus. Eukaryot Cell. 2012 Nov; 11(11):1324-32.
    View in: PubMed
    Score: 0.106
  44. Fortwendel JR, Juvvadi PR, Rogg LE, Asfaw YG, Burns KA, Randell SH, Steinbach WJ. Plasma membrane localization is required for RasA-mediated polarized morphogenesis and virulence of Aspergillus fumigatus. Eukaryot Cell. 2012 Aug; 11(8):966-77.
    View in: PubMed
    Score: 0.105
  45. Rogg LE, Fortwendel JR, Juvvadi PR, Lilley A, Steinbach WJ. The chitin synthase genes chsA and chsC are not required for cell wall stress responses in the human pathogen Aspergillus fumigatus. Biochem Biophys Res Commun. 2011 Aug 05; 411(3):549-54.
    View in: PubMed
    Score: 0.099
  46. Rogg LE, Fortwendel JR, Juvvadi PR, Steinbach WJ. Regulation of expression, activity and localization of fungal chitin synthases. Med Mycol. 2012 Jan; 50(1):2-17.
    View in: PubMed
    Score: 0.098
  47. Fortwendel JR, Juvvadi PR, Rogg LE, Steinbach WJ. Regulatable Ras activity is critical for proper establishment and maintenance of polarity in Aspergillus fumigatus. Eukaryot Cell. 2011 Apr; 10(4):611-5.
    View in: PubMed
    Score: 0.096
  48. Steinbach WJ, Juvvadi PR, Fortwendel JR, Rogg LE. Newer combination antifungal therapies for invasive aspergillosis. Med Mycol. 2011 Apr; 49 Suppl 1:S77-81.
    View in: PubMed
    Score: 0.092
  49. Fortwendel JR, Juvvadi PR, Perfect BZ, Rogg LE, Perfect JR, Steinbach WJ. Transcriptional regulation of chitin synthases by calcineurin controls paradoxical growth of Aspergillus fumigatus in response to caspofungin. Antimicrob Agents Chemother. 2010 Apr; 54(4):1555-63.
    View in: PubMed
    Score: 0.090
  50. Pinchai N, Juvvadi PR, Fortwendel JR, Perfect BZ, Rogg LE, Asfaw YG, Steinbach WJ. The Aspergillus fumigatus P-type Golgi apparatus Ca2+/Mn2+ ATPase PmrA is involved in cation homeostasis and cell wall integrity but is not essential for pathogenesis. Eukaryot Cell. 2010 Mar; 9(3):472-6.
    View in: PubMed
    Score: 0.090
  51. Pinchai N, Perfect BZ, Juvvadi PR, Fortwendel JR, Cramer RA, Asfaw YG, Heitman J, Perfect JR, Steinbach WJ. Aspergillus fumigatus calcipressin CbpA is involved in hyphal growth and calcium homeostasis. Eukaryot Cell. 2009 Apr; 8(4):511-9.
    View in: PubMed
    Score: 0.084
  52. Fortwendel JR, Juvvadi PR, Pinchai N, Perfect BZ, Alspaugh JA, Perfect JR, Steinbach WJ. Differential effects of inhibiting chitin and 1,3-{beta}-D-glucan synthesis in ras and calcineurin mutants of Aspergillus fumigatus. Antimicrob Agents Chemother. 2009 Feb; 53(2):476-82.
    View in: PubMed
    Score: 0.083
  53. Dome PA, Jeong P, Nam G, Jang H, Rivera A, Averette AF, Park E, Liao TC, Ciofani M, Wu J, Chi JA, Venters RA, Park HJ, Steinbach WJ, Juvvadi PR, Heitman J, Hong J. Structure-guided design, synthesis, and characterization of C22- and C32-modified FK520 analogs with enhanced activity against human pathogenic fungi. bioRxiv. 2024 Sep 27.
    View in: PubMed
    Score: 0.062
  54. Maji A, Soutar CP, Zhang J, Lewandowska A, Uno BE, Yan S, Shelke Y, Murhade G, Nimerovsky E, Borcik CG, Arango AS, Lange JD, Marin-Toledo JP, Lyu Y, Bailey KL, Roady PJ, Holler JT, Khandelwal A, SantaMaria AM, Sanchez H, Juvvadi PR, Johns G, Hageman MJ, Krise J, Gebremariam T, Youssef EG, Bartizal K, Marr KA, Steinbach WJ, Ibrahim AS, Patterson TF, Wiederhold NP, Andes DR, Pogorelov TV, Schwieters CD, Fan TM, Rienstra CM, Burke MD. Tuning sterol extraction kinetics yields a renal-sparing polyene antifungal. Nature. 2023 Nov; 623(7989):1079-1085.
    View in: PubMed
    Score: 0.058
  55. Rivera A, Young Lim W, Park E, Dome PA, Hoy MJ, Spasojevic I, Sun S, Averette AF, Pina-Oviedo S, Juvvadi PR, Steinbach WJ, Ciofani M, Hong J, Heitman J. Enhanced fungal specificity and in vivo therapeutic efficacy of a C-22-modified FK520 analog against C. neoformans. mBio. 2023 Oct 31; 14(5):e0181023.
    View in: PubMed
    Score: 0.058
  56. Hoy MJ, Park E, Lee H, Lim WY, Cole DC, DeBouver ND, Bobay BG, Pierce PG, Fox D, Ciofani M, Juvvadi PR, Steinbach W, Hong J, Heitman J. Structure-Guided Synthesis of FK506 and FK520 Analogs with Increased Selectivity Exhibit In Vivo Therapeutic Efficacy against Cryptococcus. mBio. 2022 06 28; 13(3):e0104922.
    View in: PubMed
    Score: 0.053
  57. Gobeil SM, Bobay BG, Juvvadi PR, Cole DC, Heitman J, Steinbach WJ, Venters RA, Spicer LD. Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs. mBio. 2021 12 21; 12(6):e0300021.
    View in: PubMed
    Score: 0.051
  58. Moseley MA, Hughes CJ, Juvvadi PR, Soderblom EJ, Lennon S, Perkins SR, Thompson JW, Steinbach WJ, Geromanos SJ, Wildgoose J, Langridge JI, Richardson K, Vissers JPC. Scanning Quadrupole Data-Independent Acquisition, Part A: Qualitative and Quantitative Characterization. J Proteome Res. 2018 02 02; 17(2):770-779.
    View in: PubMed
    Score: 0.039
  59. Moreno-Vel?squez SD, Seidel C, Juvvadi PR, Steinbach WJ, Read ND. Caspofungin-Mediated Growth Inhibition and Paradoxical Growth in Aspergillus fumigatus Involve Fungicidal Hyphal Tip Lysis Coupled with Regenerative Intrahyphal Growth and Dynamic Changes in ?-1,3-Glucan Synthase Localization. Antimicrob Agents Chemother. 2017 10; 61(10).
    View in: PubMed
    Score: 0.038
  60. Tonthat NK, Juvvadi PR, Zhang H, Lee SC, Venters R, Spicer L, Steinbach WJ, Heitman J, Schumacher MA. Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function. mBio. 2016 Apr 26; 7(2):e00492-16.
    View in: PubMed
    Score: 0.035
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.