 Kainic Acid
"Kainic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
(2S-(2 alpha,3 beta,4 beta))-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid. Ascaricide obtained from the red alga Digenea simplex. It is a potent excitatory amino acid agonist at some types of excitatory amino acid receptors and has been used to discriminate among receptor types. Like many excitatory amino acid agonists it can cause neurotoxicity and has been used experimentally for that purpose.
| Descriptor ID |
D007608
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| MeSH Number(s) |
D03.383.773.400
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| Concept/Terms |
Kainic Acid- Kainic Acid
- Acid, Kainic
- Digenic Acid
- Acid, Digenic
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Below are MeSH descriptors whose meaning is more general than "Kainic Acid".
Below are MeSH descriptors whose meaning is more specific than "Kainic Acid".
This graph shows the total number of publications written about "Kainic Acid" by people in UAMS Profiles by year, and whether "Kainic Acid" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2023 | 0 | 1 | 1 | | 2021 | 1 | 0 | 1 | | 2019 | 0 | 1 | 1 | | 2018 | 1 | 0 | 1 | | 2017 | 0 | 2 | 2 | | 2016 | 0 | 1 | 1 | | 2015 | 4 | 0 | 4 | | 2014 | 0 | 1 | 1 | | 2012 | 1 | 2 | 3 | | 2011 | 1 | 0 | 1 | | 2010 | 1 | 2 | 3 | | 2008 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 | | 2000 | 2 | 0 | 2 | | 1998 | 1 | 0 | 1 | | 1997 | 0 | 1 | 1 | | 1991 | 1 | 0 | 1 | | 1990 | 0 | 1 | 1 | | 1989 | 0 | 1 | 1 |
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Below are the most recent publications written about "Kainic Acid" by people in Profiles over the past ten years.
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Kelly KJ, Mansour A, Liang C, Kim AM, Mancini LA, Bertin MJ, Jenkins BD, Hutchins DA, Fu FX. Simulated upwelling and marine heatwave events promote similar growth rates but differential domoic acid toxicity in Pseudo-nitzschia australis. Harmful Algae. 2023 08; 127:102467.
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Kang YJ, Clement EM, Park IH, Greenfield LJ, Smith BN, Lee SH. Vulnerability of cholecystokinin-expressing GABAergic interneurons in the unilateral intrahippocampal kainate mouse model of temporal lobe epilepsy. Exp Neurol. 2021 08; 342:113724.
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Tse K, Hammond D, Simpson D, Beynon RJ, Beamer E, Tymianski M, Salter MW, Sills GJ, Thippeswamy T. The impact of postsynaptic density 95 blocking peptide (Tat-NR2B9c) and an iNOS inhibitor (1400W) on proteomic profile of the hippocampus in C57BL/6J mouse model of kainate-induced epileptogenesis. J Neurosci Res. 2019 11; 97(11):1378-1392.
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Brunson JK, McKinnie SMK, Chekan JR, McCrow JP, Miles ZD, Bertrand EM, Bielinski VA, Luhavaya H, Oborn?k M, Smith GJ, Hutchins DA, Allen AE, Moore BS. Biosynthesis of the neurotoxin domoic acid in a bloom-forming diatom. Science. 2018 09 28; 361(6409):1356-1358.
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Wyeth MS, Pelkey KA, Yuan X, Vargish G, Johnston AD, Hunt S, Fang C, Abebe D, Mahadevan V, Fisahn A, Salter MW, McInnes RR, Chittajallu R, McBain CJ. Neto Auxiliary Subunits Regulate Interneuron Somatodendritic and Presynaptic Kainate Receptors to Control Network Inhibition. Cell Rep. 2017 Aug 29; 20(9):2156-2168.
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Zhu Z, Qu P, Fu F, Tennenbaum N, Tatters AO, Hutchins DA. Understanding the blob bloom: Warming increases toxicity and abundance of the harmful bloom diatom Pseudo-nitzschia in California coastal waters. Harmful Algae. 2017 07; 67:36-43.
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Armstrong C, Wang J, Yeun Lee S, Broderick J, Bezaire MJ, Lee SH, Soltesz I. Target-selectivity of parvalbumin-positive interneurons in layer II of medial entorhinal cortex in normal and epileptic animals. Hippocampus. 2016 06; 26(6):779-93.
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Neely BA, Soper JL, Gulland FM, Bell PD, Kindy M, Arthur JM, Janech MG. Proteomic analysis of cerebrospinal fluid in California sea lions (Zalophus californianus) with domoic acid toxicosis identifies proteins associated with neurodegeneration. Proteomics. 2015 Dec; 15(23-24):4051-63.
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Neely BA, Ferrante JA, Chaves JM, Soper JL, Almeida JS, Arthur JM, Gulland FM, Janech MG. Proteomic Analysis of Plasma from California Sea Lions (Zalophus californianus) Reveals Apolipoprotein E as a Candidate Biomarker of Chronic Domoic Acid Toxicosis. PLoS One. 2014; 10(4):e0123295.
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Liachenko S, Ramu J, Konak T, Paule MG, Hanig J. Quantitative Assessment of MRI T2 Response to Kainic Acid Neurotoxicity in Rats in vivo. Toxicol Sci. 2015 Jul; 146(1):183-91.
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John CS, Sypek EI, Carlezon WA, Cohen BM, ?ng?r D, Bechtholt AJ. Blockade of the GLT-1 Transporter in the Central Nucleus of the Amygdala Induces both Anxiety and Depressive-Like Symptoms. Neuropsychopharmacology. 2015 Jun; 40(7):1700-8.
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