 Golgi Apparatus
"Golgi Apparatus" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A stack of flattened vesicles that functions in posttranslational processing and sorting of proteins, receiving them from the rough ENDOPLASMIC RETICULUM and directing them to secretory vesicles, LYSOSOMES, or the CELL MEMBRANE. The movement of proteins takes place by transfer vesicles that bud off from the rough endoplasmic reticulum or Golgi apparatus and fuse with the Golgi, lysosomes or cell membrane. (From Glick, Glossary of Biochemistry and Molecular Biology, 1990)
| Descriptor ID |
D006056
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| MeSH Number(s) |
A11.284.430.214.190.875.336
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Golgi Apparatus".
Below are MeSH descriptors whose meaning is more specific than "Golgi Apparatus".
This graph shows the total number of publications written about "Golgi Apparatus" by people in UAMS Profiles by year, and whether "Golgi Apparatus" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2025 | 0 | 1 | 1 | | 2023 | 5 | 2 | 7 | | 2022 | 1 | 0 | 1 | | 2021 | 4 | 0 | 4 | | 2020 | 3 | 2 | 5 | | 2019 | 2 | 1 | 3 | | 2018 | 5 | 1 | 6 | | 2017 | 2 | 0 | 2 | | 2016 | 4 | 0 | 4 | | 2015 | 1 | 1 | 2 | | 2014 | 2 | 1 | 3 | | 2013 | 5 | 0 | 5 | | 2012 | 6 | 1 | 7 | | 2011 | 1 | 1 | 2 | | 2010 | 2 | 0 | 2 | | 2009 | 2 | 0 | 2 | | 2008 | 1 | 1 | 2 | | 2007 | 4 | 1 | 5 | | 2006 | 2 | 1 | 3 | | 2005 | 6 | 1 | 7 | | 2004 | 2 | 1 | 3 | | 2003 | 1 | 1 | 2 | | 2002 | 3 | 0 | 3 | | 2001 | 1 | 0 | 1 | | 1999 | 1 | 0 | 1 | | 1998 | 1 | 0 | 1 | | 1997 | 1 | 1 | 2 | | 1996 | 2 | 0 | 2 | | 1993 | 2 | 0 | 2 | | 1992 | 1 | 0 | 1 |
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Below are the most recent publications written about "Golgi Apparatus" by people in Profiles over the past ten years.
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Khakurel A, Pokrovskaya I, Aragon-Ramirez WS, Lupashin VV. Acute GARP Depletion Disrupts Vesicle Transport, Leading to Severe Defects in Sorting, Secretion and O-Glycosylation. Traffic. 2025 Jan-Mar; 26(1-3):e70003.
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Marsilia C, Batra M, Pokrovskaya ID, Wang C, Chaput D, Naumova DA, Lupashin VV, Suvorova ES. Essential role of the conserved oligomeric Golgi complex in Toxoplasma gondii. mBio. 2023 Dec 19; 14(6):e0251323.
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D'Souza Z, Pokrovskaya I, Lupashin VV. Syntaxin-5's flexibility in SNARE pairing supports Golgi functions. Traffic. 2023 08; 24(8):355-379.
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Vicogne D, Beauval N, Durin Z, Allorge D, Kondratska K, Haustrate A, Prevarskaya N, Lupashin V, Legrand D, Foulquier F. Insights into the regulation of cellular Mn2+ homeostasis via TMEM165. Biochim Biophys Acta Mol Basis Dis. 2023 08; 1869(6):166717.
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Khakurel A, Lupashin VV. Role of GARP Vesicle Tethering Complex in Golgi Physiology. Int J Mol Sci. 2023 Mar 23; 24(7).
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Liu S, Pokrovskaya ID, Storrie B. High-Pressure Freezing Followed by Freeze Substitution: An Optimal Electron Microscope Technique to Study Golgi Apparatus Organization and Membrane Trafficking. Methods Mol Biol. 2023; 2557:211-223.
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Khakurel A, Kudlyk T, Lupashin VV. Generation and Analysis of hTERT-RPE1 VPS54 Knock-Out and Rescued Cell Lines. Methods Mol Biol. 2023; 2557:349-364.
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Sumya FT, Pokrovskaya ID, Lupashin VV. Rapid COG Depletion in Mammalian Cell by Auxin-Inducible Degradation System. Methods Mol Biol. 2023; 2557:365-390.
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Sumya FT, Pokrovskaya ID, D'Souza Z, Lupashin VV. Acute COG complex inactivation unveiled its immediate impact on Golgi and illuminated the nature of intra-Golgi recycling vesicles. Traffic. 2023 Feb; 24(2):52-75.
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D'Souza Z, Sumya FT, Khakurel A, Lupashin V. Getting Sugar Coating Right! The Role of the Golgi Trafficking Machinery in Glycosylation. Cells. 2021 11 23; 10(12).
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Khakurel A, Kudlyk T, Bonifacino JS, Lupashin VV. The Golgi-associated retrograde protein (GARP) complex plays an essential role in the maintenance of the Golgi glycosylation machinery. Mol Biol Cell. 2021 08 15; 32(17):1594-1610.
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Adusumalli R, ?sheim HC, Lupashin V, Blackburn JB, Prydz K. Proteoglycan synthesis in conserved oligomeric Golgi subunit deficient HEK293T cells is affected differently, depending on the lacking subunit. Traffic. 2021 07; 22(7):230-239.
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Klemens CA, Chulkov EG, Wu J, Hye Khan MA, Levchenko V, Flister MJ, Imig JD, Kriegel AJ, Palygin O, Staruschenko A. Loss of Chloride Channel 6 (CLC-6) Affects Vascular Smooth Muscle Contractility and Arterial Stiffness via Alterations to Golgi Calcium Stores. Hypertension. 2021 02; 77(2):582-593.
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Hartwig C, M?ndez GM, Bhattacharjee S, Vrailas-Mortimer AD, Zlatic SA, Freeman AAH, Gokhale A, Concilli M, Werner E, Sapp Savas C, Rudin-Rush S, Palmer L, Shearing N, Margewich L, McArthy J, Taylor S, Roberts B, Lupashin V, Polishchuk RS, Cox DN, Jorquera RA, Faundez V. Golgi-Dependent Copper Homeostasis Sustains Synaptic Development and Mitochondrial Content. J Neurosci. 2021 01 13; 41(2):215-233.
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Petitjean O, Girardi E, Ngondo RP, Lupashin V, Pfeffer S. Genome-Wide CRISPR-Cas9 Screen Reveals the Importance of the Heparan Sulfate Pathway and the Conserved Oligomeric Golgi Complex for Synthetic Double-Stranded RNA Uptake and Sindbis Virus Infection. mSphere. 2020 11 11; 5(6).
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Dickson LJ, Liu S, Storrie B. Rab6 is required for rapid, cisternal-specific, intra-Golgi cargo transport. Sci Rep. 2020 10 06; 10(1):16604.
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D'Souza Z, Taher FS, Lupashin VV. Golgi inCOGnito: From vesicle tethering to human disease. Biochim Biophys Acta Gen Subj. 2020 11; 1864(11):129694.
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Realegeno S, Priyamvada L, Kumar A, Blackburn JB, Hartloge C, Puschnik AS, Sambhara S, Olson VA, Carette JE, Lupashin V, Satheshkumar PS. Conserved Oligomeric Golgi (COG) Complex Proteins Facilitate Orthopoxvirus Entry, Fusion and Spread. Viruses. 2020 06 30; 12(7).
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Vicogne D, Houdou M, Garat A, Climer L, Lupashin V, Morelle W, Foulquier F. Fetal bovine serum impacts the observed N-glycosylation defects in TMEM165 KO HEK cells. J Inherit Metab Dis. 2020 03; 43(2):357-366.
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Blackburn JB, D'Souza Z, Lupashin VV. Maintaining order: COG complex controls Golgi trafficking, processing, and sorting. FEBS Lett. 2019 09; 593(17):2466-2487.
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Lebredonchel E, Houdou M, Potelle S, de Bettignies G, Schulz C, Krzewinski Recchi MA, Lupashin V, Legrand D, Klein A, Foulquier F. Dissection of TMEM165 function in Golgi glycosylation and its Mn2+ sensitivity. Biochimie. 2019 Oct; 165:123-130.
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Kondo Y, Fu J, Wang H, Hoover C, McDaniel JM, Steet R, Patra D, Song J, Pollard L, Cathey S, Yago T, Wiley G, Macwana S, Guthridge J, McGee S, Li S, Griffin C, Furukawa K, James JA, Ruan C, McEver RP, Wierenga KJ, Gaffney PM, Xia L. Site-1 protease deficiency causes human skeletal dysplasia due to defective inter-organelle protein trafficking. JCI Insight. 2018 07 26; 3(14).
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Ishii M, Lupashin VV, Nakano A. Detailed Analysis of the Interaction of Yeast COG Complex. Cell Struct Funct. 2018 Jul 19; 43(2):119-127.
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Blackburn JB, Kudlyk T, Pokrovskaya I, Lupashin VV. More than just sugars: Conserved oligomeric Golgi complex deficiency causes glycosylation-independent cellular defects. Traffic. 2018 06; 19(6):463-480.
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Climer LK, Pokrovskaya ID, Blackburn JB, Lupashin VV. Membrane detachment is not essential for COG complex function. Mol Biol Cell. 2018 04 15; 29(8):964-974.
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Goud B, Liu S, Storrie B. Rab proteins as major determinants of the Golgi complex structure. Small GTPases. 2018 03 04; 9(1-2):66-75.
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Climer LK, Hendrix RD, Lupashin VV. Conserved Oligomeric Golgi and Neuronal Vesicular Trafficking. Handb Exp Pharmacol. 2018; 245:227-247.
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Miller CN, Smith EP, Cundiff JA, Knodler LA, Bailey Blackburn J, Lupashin V, Celli J. A Brucella Type IV Effector Targets the COG Tethering Complex to Remodel Host Secretory Traffic and Promote Intracellular Replication. Cell Host Microbe. 2017 Sep 13; 22(3):317-329.e7.
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Potelle S, Dulary E, Climer L, Duvet S, Morelle W, Vicogne D, Lebredonchel E, Houdou M, Spriet C, Krzewinski-Recchi MA, Peanne R, Klein A, de Bettignies G, Morsomme P, Matthijs G, Marquardt T, Lupashin V, Foulquier F. Manganese-induced turnover of TMEM165. Biochem J. 2017 04 19; 474(9):1481-1493.
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Yadav S, Williamson JK, Aronova MA, Prince AA, Pokrovskaya ID, Leapman RD, Storrie B. Golgi proteins in circulating human platelets are distributed across non-stacked, scattered structures. Platelets. 2017 Jun; 28(4):400-408.
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Willett R, Blackburn JB, Climer L, Pokrovskaya I, Kudlyk T, Wang W, Lupashin V. COG lobe B sub-complex engages v-SNARE GS15 and functions via regulated interaction with lobe A sub-complex. Sci Rep. 2016 07 07; 6:29139.
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Joo JH, Wang B, Frankel E, Ge L, Xu L, Iyengar R, Li-Harms X, Wright C, Shaw TI, Lindsten T, Green DR, Peng J, Hendershot LM, Kilic F, Sze JY, Audhya A, Kundu M. The Noncanonical Role of ULK/ATG1 in ER-to-Golgi Trafficking Is Essential for Cellular Homeostasis. Mol Cell. 2016 05 19; 62(4):491-506.
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Blackburn JB, Lupashin VV. Creating Knockouts of Conserved Oligomeric Golgi Complex Subunits Using CRISPR-Mediated Gene Editing Paired with a Selection Strategy Based on Glycosylation Defects Associated with Impaired COG Complex Function. Methods Mol Biol. 2016; 1496:145-61.
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