 Anesthetics, Local
"Anesthetics, Local" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.
| Descriptor ID |
D000779
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| MeSH Number(s) |
D27.505.696.277.100.200 D27.505.696.663.850.025 D27.505.954.427.210.100.200
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| Concept/Terms |
Anesthetics, Local- Anesthetics, Local
- Local Anesthetics
- Conduction-Blocking Anesthetics
- Conduction Blocking Anesthetics
- Anesthetics, Conduction-Blocking
- Anesthetics, Conduction Blocking
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Below are MeSH descriptors whose meaning is more general than "Anesthetics, Local".
Below are MeSH descriptors whose meaning is more specific than "Anesthetics, Local".
This graph shows the total number of publications written about "Anesthetics, Local" by people in UAMS Profiles by year, and whether "Anesthetics, Local" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2024 | 0 | 1 | 1 | | 2023 | 0 | 1 | 1 | | 2022 | 0 | 4 | 4 | | 2021 | 2 | 1 | 3 | | 2020 | 1 | 0 | 1 | | 2019 | 2 | 0 | 2 | | 2018 | 0 | 1 | 1 | | 2017 | 2 | 0 | 2 | | 2016 | 3 | 1 | 4 | | 2015 | 1 | 4 | 5 | | 2013 | 4 | 1 | 5 | | 2012 | 0 | 1 | 1 | | 2011 | 2 | 0 | 2 | | 2009 | 4 | 0 | 4 | | 2008 | 1 | 0 | 1 | | 2006 | 1 | 2 | 3 | | 2005 | 1 | 0 | 1 | | 2004 | 1 | 1 | 2 | | 2003 | 3 | 0 | 3 | | 2002 | 2 | 2 | 4 | | 2001 | 2 | 0 | 2 | | 1999 | 1 | 0 | 1 | | 1997 | 2 | 0 | 2 | | 1996 | 2 | 0 | 2 | | 1995 | 2 | 0 | 2 | | 1993 | 1 | 0 | 1 | | 1992 | 0 | 1 | 1 |
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Below are the most recent publications written about "Anesthetics, Local" by people in Profiles over the past ten years.
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Banik RK, Tran BW, Belfar A, Akhtaruzzaman AKM, Nada E, Hanson N. Therapeutic efficacy of intravenous lidocaine infusion compared with thoracic epidural analgesia in major abdominal surgery: factors affecting successful thoracic epidural analgesia. Comment on Br J Anaesth 2023; 131: 947-54. Br J Anaesth. 2024 May; 132(5):1169-1170.
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Park SH, Wilson SK, Wen L. Subcoronal Incision for Inflatable Penile Prosthesis Does Not Risk Glans Necrosis. J Urol. 2023 10; 210(4):678-687.
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Fillingham YA, Hannon CP, Kopp SL, Austin MS, Sershon RA, Stronach BM, Meneghini RM, Abdel MP, Griesemer ME, Woznica A, Casambre FD, Nelson N, Hamilton WG, Della Valle CJ. The Efficacy and Safety of Regional Nerve Blocks in Total Knee Arthroplasty: Systematic Review and Direct Meta-Analysis. J Arthroplasty. 2022 10; 37(10):1906-1921.e2.
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Stephens RJ, Filip AB, Baumgartner KT, Schwarz ES, Liss DB. Benzonatate Overdose Presenting as Cardiac Arrest with Rapidly Narrowing QRS Interval. J Med Toxicol. 2022 10; 18(4):344-349.
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Oberhofer HM, Rao A, Carlson JT, Mast BA, Simmons CJ, Gutowski KA, Satteson ES. Opioid Prescribing Practices Among Plastic Surgeons: Results of the 2019 American Society of Plastic Surgeons Opioid Survey. Ann Plast Surg. 2022 06 01; 88(6):665-673.
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Sharawi N, Tan HS, Taylor C, Fuller ME, Landreth RA, Diomede OI, Williams M, Martinello C, Mhyre JM, Habib AS. ED 90 of Intrathecal Chloroprocaine With Fentanyl for Prophylactic Cervical Cerclage: A Sequential Allocation Biased-Coin Design. Anesth Analg. 2022 04 01; 134(4):834-842.
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Gonzalez R, Dunn A, Williams L, Weber J, Erkanli A, Havrilesky LJ, Selim MA. Histopathology after lidocaine/prilocaine cream administration for vulvar biopsy. J Cutan Pathol. 2021 Oct; 48(10):1239-1245.
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Sharawi N, Bansal P, Williams M, Spencer H, Mhyre JM. Comparison of Chloroprocaine Versus Lidocaine With Epinephrine, Sodium Bicarbonate, and Fentanyl for Epidural Extension Anesthesia in Elective Cesarean Delivery: A Randomized, Triple-Blind, Noninferiority Study. Anesth Analg. 2021 03 01; 132(3):666-675.
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Staity G, Saadi RA, Pool C, Lighthall JG. The Safety Profile of Liposomal Bupivacaine Use in Septorhinoplasty. Facial Plast Surg Aesthet Med. 2022 May-Jun; 24(3):202-206.
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Ho ATN, Gandhiraj D, Jamkhana Z, Nayak R, Patolia S. Is Additional Nebulized Lidocaine Helpful in Flexible Bronchoscopy?: A Meta-Analysis. J Bronchology Interv Pulmonol. 2020 Oct; 27(4):266-273.
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Bansal P, Garg S. Effect of Adding Dexmedetomidine to Local Anesthetic Agents for Transversus Abdominis Plane Block: A Meta-analysis. Clin J Pain. 2019 10; 35(10):844-854.
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Patel SD, Sharawi N, Sultan P. Local anaesthetic techniques for post-caesarean delivery analgesia. Int J Obstet Anesth. 2019 11; 40:62-77.
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Arthur J, Duran-Gehring P, Kumetz C, Chadwick S, McIntosh M. Cerebral Venous Thrombosis: An Uncommon Cause of Papilledema on Bedside Ocular Ultrasound. J Emerg Med. 2019 Mar; 56(3):288-293.
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Shaw KA, Moreland C, Jacobs J, Hire JM, Topolski R, Hoyt N, Parada SA, Cameron CD. Improved Chondrotoxic Profile of Liposomal Bupivacaine Compared With Standard Bupivacaine After Intra-articular Infiltration in a Porcine Model. Am J Sports Med. 2018 Jan; 46(1):66-71.
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Saied NN, Gupta RK, Saffour L, Helwani MA. Dexamethasone and Clonidine, but not Epinephrine, Prolong Duration of Ropivacaine Brachial Plexus Blocks, Cross-Sectional Analysis in Outpatient Surgery Setting. Pain Med. 2017 Oct 01; 18(10):2013-2026.
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Kent S, Mehaffey G. Transnasal sphenopalatine ganglion block for the treatment of postdural puncture headache in obstetric patients. J Clin Anesth. 2016 Nov; 34:194-6.
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Karkera MM, Harrison DR, Aunspaugh JP, Martin TW. Assessing Caudal Block Concentrations of Bupivacaine With and Without the Addition of Intravenous Fentanyl on Postoperative Outcomes in Pediatric Patients: A Retrospective Review. Am J Ther. 2016 May-Jun; 23(3):e792-8.
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Ornelas J, Foolad N, Shi V, Burney W, Sivamani RK. Effect of Microneedle Pretreatment on Topical Anesthesia: A Randomized Clinical Trial. JAMA Dermatol. 2016 Apr; 152(4):476-7.
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Jacob S, Ly H, Villenueva RJ, Gupta HV. Acute dystonic reaction in a patient with Parkinson's disease after diphenhydramine withdrawal. Acta Neurol Belg. 2017 03; 117(1):345-346.
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Zempsky WT, Schmitz ML, Meyer JM. Safety and Efficacy of Needle-free Powder Lidocaine Delivery System in Adult Patients Undergoing Venipuncture or Peripheral Venous Cannulation: A Randomized, Double-Blind, Placebo-controlled Trial. Clin J Pain. 2016 Mar; 32(3):211-7.
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Du K, McGill MR, Xie Y, Jaeschke H. Benzyl alcohol protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes but causes mitochondrial dysfunction and cell death at higher doses. Food Chem Toxicol. 2015 Dec; 86:253-61.
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Schmitz ML, Zempsky WT, Meyer JM. Safety and Efficacy of a Needle-free Powder Lidocaine Delivery System in Pediatric Patients Undergoing Venipuncture or Peripheral Venous Cannulation: Randomized Double-blind COMFORT-004 Trial. Clin Ther. 2015 Aug; 37(8):1761-72.
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Sallam AA, Donachie PH, Williamson TH, Sparrow JM, Johnston RL. The Royal College of Ophthalmologists' National Ophthalmology Database Study of vitreoretinal surgery: report 5, anaesthetic techniques. Br J Ophthalmol. 2016 Feb; 100(2):246-52.
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Heim EA, Grier AJ, Butler RJ, Bushmiaer M, Queen RM, Barnes CL. Use of Liposomal Bupivacaine Instead of an Epidural Can Improve Outcomes Following Total Knee Arthroplasty. J Surg Orthop Adv. 2015; 24(4):230-4.
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Connelly JO, Edwards PK, Mears SC, Barnes CL. Technique for Periarticular Local Infiltrative Anesthesia Delivery Using Liposomal Bupivacaine in Total Knee Arthroplasty. J Surg Orthop Adv. 2015; 24(4):263-6.
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