Yong-Chen Lu
Title | Assistant Professor |
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Institution | University of Arkansas for Medical Sciences |
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Department | Pathology, College of Medicine |
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Division | Pathology Academic |
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Address | 4301 W. Markham Mail Slot # 845 Little Rock AR 72205
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ORCID
| 0000-0002-0275-9825 |
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vCard | Download vCard |
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Research Pilot (Lu, Yong-Chen)Sep 1, 2023 - Aug 31, 2025 ABCRP Developing CD4 T cell-based immunotherapy for breast cancer Role: Principal Investigator |
| 69-21807-01-01-G1 (LU, YONG-CHEN)Oct 1, 2022 - Sep 30, 2023 The Mark Foundation for Cancer Research - Pass Through: H Lee Moffitt Cancer Center & Research Institute Defining tumor infiltrating B cells and their role in the modulation of TIL immunotherapy Role: Co-Investigator |
| KL2 (LU, YONG-CHEN)Jul 1, 2021 - Jun 30, 2023 TRI A pilot study of developing T cell-based cancer immunotherapies for African American and Hispanic populations Role: Principal Investigator |
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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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Xiong X, Liu JM, Lu WW, Yang KD, Qi H, Liu ZL, Zhang N, Huang SH. The Effectiveness of Artificial Intelligence-based Pedicle Screw Trajectory Planning in Patients With Different Levels of Bone Mineral Density. Clin Spine Surg. 2024 Sep 03. PMID: 39226101.
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Bian S, Hu X, Zhu H, Du W, Wang C, Wang L, Hao L, Xiang Y, Meng F, Hu C, Wu Z, Wang J, Pan X, Guan M, Lu WW, Zhao X. 3D Bioprinting of Artificial Skin Substitute with Improved Mechanical Property and Regulated Cell Behavior through Integrating Patterned Nanofibrous Films. ACS Nano. 2024 Jul 16; 18(28):18503-18521. PMID: 38941540.
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Carr JC, Pedagandham SP, Giugni A, Shen C, Kim AM, Cribbin EM, Lin X, Oomatia A, Lu W, Al Muderis M, Xing D, Li JJ. Bone mineral density in osseointegration implant surgery: A review of current studies (Review). Biomed Rep. 2024 Aug; 21(2):122. PMID: 38978538.
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Su R, Wang L, Han F, Bian S, Meng F, Qi W, Zhai X, Li H, Wu J, Pan X, Pan H, Guo P, Lu WW, Liu Z, Zhao X. A highly stretchable smart dressing for wound infection monitoring and treatment. Mater Today Bio. 2024 Jun; 26:101107. PMID: 38952538.
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Kirkpatrick C, Lu YW. Deciphering CD4+ T cell-mediated responses against cancer. Mol Carcinog. 2024 Jul; 63(7):1209-1220. PMID: 38725218.
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Huang T, Lu Z, Wang Z, Cheng L, Gao L, Gao J, Zhang N, Geng CA, Zhao X, Wang H, Wong CW, Yeung KWK, Pan H, Lu WW, Guan M. Targeting adipocyte ESRRA promotes osteogenesis and vascular formation in adipocyte-rich bone marrow. Nat Commun. 2024 May 04; 15(1):3769. PMID: 38704393.
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Liu J, Huang X, Su H, Yu J, Nie X, Liu K, Qin W, Zhao Y, Su Y, Kuang X, Chen D, Lu WW, Chen Y, Hua Q. Tibial Cortex Transverse Transport Facilitates Severe Diabetic Foot Wound Healing via HIF-1a-Induced Angiogenesis. J Inflamm Res. 2024; 17:2681-2696. PMID: 38707956.
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Huang X, Chen Y, Zeng D, Liang R, Liao Z, Wei G, Hao W, Lu W, Chen Y. Complete resorption of the humerus in metastatic thyroid carcinoma: a case report. BMC Musculoskelet Disord. 2024 Feb 27; 25(1):177. PMID: 38413955.
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Chen Y, Zeng D, Wei G, Liao Z, Liang R, Huang X, Lu WW, Chen Y. Pyroptosis in Osteoarthritis: Molecular Mechanisms and Therapeutic Implications. J Inflamm Res. 2024; 17:791-803. PMID: 38348279.
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Feng J, Zhang Q, Pu F, Zhu Z, Lu K, Lu WW, Tong L, Yu H, Chen D. Signalling interaction between ?-catenin and other signalling molecules during osteoarthritis development. Cell Prolif. 2024 Jun; 57(6):e13600. PMID: 38199244.
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Wei G, Lu K, Umar M, Zhu Z, Lu WW, Speakman JR, Chen Y, Tong L, Chen D. Risk of metabolic abnormalities in osteoarthritis: a new perspective to understand its pathological mechanisms. Bone Res. 2023 12 06; 11(1):63. PMID: 38052778.
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Yi D, Jin H, Lu WW, Zhang C, Xiao G, Tong L, Chen D. Deletion of Axin1 in aggrecan-expressing cells leads to growth plate cartilage defects in adult mice. Genes Dis. 2024 Jul; 11(4):101147. PMID: 38515941.
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Chen Y, Ding X, Zhu Y, Jia Z, Qi Y, Chen M, Lu J, Kuang X, Zhou J, Su Y, Zhao Y, Lu W, Zhao J, Hua Q. Effect of tibial cortex transverse transport in patients with recalcitrant diabetic foot ulcers: A prospective multicenter cohort study. J Orthop Translat. 2022 Sep; 36:194-204. PMID: 36263383.
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Kim SP, Vale NR, Zacharakis N, Krishna S, Yu Z, Gasmi B, Gartner JJ, Sindiri S, Malekzadeh P, Deniger DC, Lowery FJ, Parkhurst MR, Ngo LT, Ray S, Li YF, Hill V, Florentin M, Masi RV, Paria BC, Levin N, Bera A, Hedges EA, Choi A, Chatani PD, Parikh AY, Levi S, Seitter S, Lu YC, Zheng Z, Prickett TD, Jia L, Hernandez JM, Hoang CD, Robbins PF, Goff SL, Sherry RM, Yang JC, Rosenberg SA. Adoptive Cellular Therapy with Autologous Tumor-Infiltrating Lymphocytes and T-cell Receptor-Engineered T Cells Targeting Common p53 Neoantigens in Human Solid Tumors. Cancer Immunol Res. 2022 08 03; 10(8):932-946. PMID: 35749374.
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Lin CC, Chang TY, Lu YC, Wu YS, Huang W, Lo WC, Liu GF, Hsu WC, Ohashi PS, Mak TW, Fuh JL, Chen HC, Tarng DC, Chen NJ. TREM-2 mediates dendritic cell-induced NO to suppress Th17 activation and ameliorate chronic kidney diseases. J Mol Med (Berl). 2022 06; 100(6):917-931. PMID: 35532794.
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Dai L, Lu YC, Chen J, Plaisance-Bonstaff K, Mu S, Forrest JC, Whitby D, Post SR, Qin Z. Oral Shedding of an Oncogenic Virus Alters the Oral Microbiome in HIV+ Patients. Front Microbiol. 2022; 13:882520. PMID: 35516440.
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Lowery FJ, Krishna S, Yossef R, Parikh NB, Chatani PD, Zacharakis N, Parkhurst MR, Levin N, Sindiri S, Sachs A, Hitscherich KJ, Yu Z, Vale NR, Lu YC, Zheng Z, Jia L, Gartner JJ, Hill VK, Copeland AR, Nah SK, Masi RV, Gasmi B, Kivitz S, Paria BC, Florentin M, Kim SP, Hanada KI, Li YF, Ngo LT, Ray S, Shindorf ML, Levi ST, Shepherd R, Toy C, Parikh AY, Prickett TD, Kelly MC, Beyer R, Goff SL, Yang JC, Robbins PF, Rosenberg SA. Molecular signatures of antitumor neoantigen-reactive T cells from metastatic human cancers. Science. 2022 02 25; 375(6583):877-884. PMID: 35113651.
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Davis L, Tarduno A, Lu YC. Neoantigen-Reactive T Cells: The Driving Force behind Successful Melanoma Immunotherapy. Cancers (Basel). 2021 Dec 01; 13(23). PMID: 34885172.
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Shibata T, Shah S, Evans T, Coleman H, Lieblong BJ, Spencer HJ, Quick CM, Sasagawa T, Stephens OW, Peterson E, Johann D, Lu YC, Nakagawa M. Expansion of Human Papillomavirus-Specific T Cells in Periphery and Cervix in a Therapeutic Vaccine Recipient Whose Cervical High-Grade Squamous Intraepithelial Lesion Regressed. Front Immunol. 2021; 12:645299. PMID: 34659195.
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Maravelia P, Silva DN, Rovesti G, Chrobok M, St?l P, Lu YC, Pasetto A. Liquid Biopsy in Hepatocellular Carcinoma: Opportunities and Challenges for Immunotherapy. Cancers (Basel). 2021 Aug 27; 13(17). PMID: 34503144.
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Leko V, Cafri G, Yossef R, Paria B, Hill V, Gurusamy D, Zheng Z, Gartner JJ, Prickett TD, Goff SL, Robbins P, Lu YC, Rosenberg SA. Identification of neoantigen-reactive T lymphocytes in the peripheral blood of a patient with glioblastoma. J Immunother Cancer. 2021 07; 9(7). PMID: 34266885.
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Lu YC, Zheng Z, Lowery FJ, Gartner JJ, Prickett TD, Robbins PF, Rosenberg SA. Direct identification of neoantigen-specific TCRs from tumor specimens by high-throughput single-cell sequencing. J Immunother Cancer. 2021 07; 9(7). PMID: 34321276.
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Pasetto A, Lu YC. Single-Cell TCR and Transcriptome Analysis: An Indispensable Tool for Studying T-Cell Biology and Cancer Immunotherapy. Front Immunol. 2021; 12:689091. PMID: 34163487.
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Lu YC, Wang XJ. Harnessing the power of the immune system in cancer immunotherapy and cancer prevention. Mol Carcinog. 2020 07; 59(7):675-678. PMID: 32386070.
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Robbins PF, Lu YC. Immunology of Melanoma. Balch C. et al. (eds) Cutaneous Melanoma. Springer, Cham. 2020; 41-72.
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Lu YC, Jia L, Zheng Z, Tran E, Robbins PF, Rosenberg SA. Single-Cell Transcriptome Analysis Reveals Gene Signatures Associated with T-cell Persistence Following Adoptive Cell Therapy. Cancer Immunol Res. 2019 Nov; 7(11):1824-1836. PMID: 31484655.
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Goff SL, Morgan RA, Yang JC, Sherry RM, Robbins PF, Restifo NP, Feldman SA, Lu YC, Lu L, Zheng Z, Xi L, Epstein M, McIntyre LS, Malekzadeh P, Raffeld M, Fine HA, Rosenberg SA. Pilot Trial of Adoptive Transfer of Chimeric Antigen Receptor-transduced T Cells Targeting EGFRvIII in Patients With Glioblastoma. J Immunother. 2019 05; 42(4):126-135. PMID: 30882547.
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Leko V, McDuffie LA, Zheng Z, Gartner JJ, Prickett TD, Apolo AB, Agarwal PK, Rosenberg SA, Lu YC. Identification of Neoantigen-Reactive Tumor-Infiltrating Lymphocytes in Primary Bladder Cancer. J Immunol. 2019 06 15; 202(12):3458-3467. PMID: 31036766.
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Lo W, Parkhurst M, Robbins PF, Tran E, Lu YC, Jia L, Gartner JJ, Pasetto A, Deniger D, Malekzadeh P, Shelton TE, Prickett T, Ray S, Kivitz S, Paria BC, Kriley I, Schrump DS, Rosenberg SA. Immunologic Recognition of a Shared p53 Mutated Neoantigen in a Patient with Metastatic Colorectal Cancer. Cancer Immunol Res. 2019 04; 7(4):534-543. PMID: 30709841.
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Cafri G, Yossef R, Pasetto A, Deniger DC, Lu YC, Parkhurst M, Gartner JJ, Jia L, Ray S, Ngo LT, Jafferji M, Sachs A, Prickett T, Robbins PF, Rosenberg SA. Memory T cells targeting oncogenic mutations detected in peripheral blood of epithelial cancer patients. Nat Commun. 2019 01 25; 10(1):449. PMID: 30683863.
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Zacharakis N, Chinnasamy H, Black M, Xu H, Lu YC, Zheng Z, Pasetto A, Langhan M, Shelton T, Prickett T, Gartner J, Jia L, Trebska-McGowan K, Somerville RP, Robbins PF, Rosenberg SA, Goff SL, Feldman SA. Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer. Nat Med. 2018 06; 24(6):724-730. PMID: 29867227.
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Lu YC, Zheng Z, Robbins PF, Tran E, Prickett TD, Gartner JJ, Li YF, Ray S, Franco Z, Bliskovsky V, Fitzgerald PC, Rosenberg SA. An Efficient Single-Cell RNA-Seq Approach to Identify Neoantigen-Specific T Cell Receptors. Mol Ther. 2018 02 07; 26(2):379-389. PMID: 29174843.
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Lu YC, Parker LL, Lu T, Zheng Z, Toomey MA, White DE, Yao X, Li YF, Robbins PF, Feldman SA, van der Bruggen P, Klebanoff CA, Goff SL, Sherry RM, Kammula US, Yang JC, Rosenberg SA. Treatment of Patients With Metastatic Cancer Using a Major Histocompatibility Complex Class II-Restricted T-Cell Receptor Targeting the Cancer Germline Antigen MAGE-A3. J Clin Oncol. 2017 Oct 10; 35(29):3322-3329. PMID: 28809608.
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Assadipour Y, Zacharakis N, Crystal JS, Prickett TD, Gartner JJ, Somerville RPT, Xu H, Black MA, Jia L, Chinnasamy H, Kriley I, Lu L, Wunderlich JR, Zheng Z, Lu YC, Robbins PF, Rosenberg SA, Goff SL, Feldman SA. Characterization of an Immunogenic Mutation in a Patient with Metastatic Triple-Negative Breast Cancer. Clin Cancer Res. 2017 Aug 01; 23(15):4347-4353. PMID: 28377481.
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Tran E, Robbins PF, Lu YC, Prickett TD, Gartner JJ, Jia L, Pasetto A, Zheng Z, Ray S, Groh EM, Kriley IR, Rosenberg SA. T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer. N Engl J Med. 2016 Dec 08; 375(23):2255-2262. PMID: 27959684.
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Yao X, Lu YC, Parker LL, Li YF, El-Gamil M, Black MA, Xu H, Feldman SA, van der Bruggen P, Rosenberg SA, Robbins PF. Isolation and Characterization of an HLA-DPB1*04: 01-restricted MAGE-A3 T-Cell Receptor for Cancer Immunotherapy. J Immunother. 2016 06; 39(5):191-201. PMID: 27163739.
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Lu YC, Robbins PF. Targeting neoantigens for cancer immunotherapy. Int Immunol. 2016 07; 28(7):365-70. PMID: 27208041.
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Lu YC, Robbins PF. Cancer immunotherapy targeting neoantigens. Semin Immunol. 2016 02; 28(1):22-7. PMID: 26653770.
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Tran E, Ahmadzadeh M, Lu YC, Gros A, Turcotte S, Robbins PF, Gartner JJ, Zheng Z, Li YF, Ray S, Wunderlich JR, Somerville RP, Rosenberg SA. Immunogenicity of somatic mutations in human gastrointestinal cancers. Science. 2015 Dec 11; 350(6266):1387-90. PMID: 26516200.
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Leu CM, Lu YC, Peng WL, Chu HT, Hu CP. The hepatitis B virus e antigen suppresses the respiratory burst and mobility of human monocytes and neutrophils. Immunobiology. 2014 Nov; 219(11):880-7. PMID: 25123430.
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Lu YC, Yao X, Crystal JS, Li YF, El-Gamil M, Gross C, Davis L, Dudley ME, Yang JC, Samuels Y, Rosenberg SA, Robbins PF. Efficient identification of mutated cancer antigens recognized by T cells associated with durable tumor regressions. Clin Cancer Res. 2014 Jul 01; 20(13):3401-10. PMID: 24987109.
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Tran E, Turcotte S, Gros A, Robbins PF, Lu YC, Dudley ME, Wunderlich JR, Somerville RP, Hogan K, Hinrichs CS, Parkhurst MR, Yang JC, Rosenberg SA. Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer. Science. 2014 May 09; 344(6184):641-5. PMID: 24812403.
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Lu YC, Yao X, Li YF, El-Gamil M, Dudley ME, Yang JC, Almeida JR, Douek DC, Samuels Y, Rosenberg SA, Robbins PF. Mutated PPP1R3B is recognized by T cells used to treat a melanoma patient who experienced a durable complete tumor regression. J Immunol. 2013 Jun 15; 190(12):6034-42. PMID: 23690473.
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Robbins PF, Lu YC, El-Gamil M, Li YF, Gross C, Gartner J, Lin JC, Teer JK, Cliften P, Tycksen E, Samuels Y, Rosenberg SA. Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells. Nat Med. 2013 Jun; 19(6):747-52. PMID: 23644516.
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Yao X, Ahmadzadeh M, Lu YC, Liewehr DJ, Dudley ME, Liu F, Schrump DS, Steinberg SM, Rosenberg SA, Robbins PF. Levels of peripheral CD4(+)FoxP3(+) regulatory T cells are negatively associated with clinical response to adoptive immunotherapy of human cancer. Blood. 2012 Jun 14; 119(24):5688-96. PMID: 22555974.
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Lin WJ, Su YW, Lu YC, Hao Z, Chio II, Chen NJ, Br?stle A, Li WY, Mak TW. Crucial role for TNF receptor-associated factor 2 (TRAF2) in regulating NF?B2 signaling that contributes to autoimmunity. Proc Natl Acad Sci U S A. 2011 Nov 08; 108(45):18354-9. PMID: 22042853.
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Jacobs C, Huang Y, Masud T, Lu W, Westfield G, Giblin W, Sekiguchi JM. A hypomorphic Artemis human disease allele causes aberrant chromosomal rearrangements and tumorigenesis. Hum Mol Genet. 2011 Feb 15; 20(4):806-19. PMID: 21147755.
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Deenick EK, Po L, Chapatte L, Murakami K, Lu YC, Elford AR, Saibil SD, Ruland J, Gerondakis S, Mak TW, Ohashi PS. c-Rel phenocopies PKCtheta but not Bcl-10 in regulating CD8+ T-cell activation versus tolerance. Eur J Immunol. 2010 Mar; 40(3):867-77. PMID: 19950170.
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Lu YC, Kim I, Lye E, Shen F, Suzuki N, Suzuki S, Gerondakis S, Akira S, Gaffen SL, Yeh WC, Ohashi PS. Differential role for c-Rel and C/EBPbeta/delta in TLR-mediated induction of proinflammatory cytokines. J Immunol. 2009 Jun 01; 182(11):7212-21. PMID: 19454718.
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Lu YC, Yeh WC, Ohashi PS. LPS/TLR4 signal transduction pathway. Cytokine. 2008 May; 42(2):145-151. PMID: 18304834.
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Chen NJ, Mirtsos C, Suh D, Lu YC, Lin WJ, McKerlie C, Lee T, Baribault H, Tian H, Yeh WC. C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a. Nature. 2007 Mar 08; 446(7132):203-7. PMID: 17322907.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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Year | Publications |
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2007 | 1 | 2008 | 1 | 2009 | 1 | 2010 | 2 | 2011 | 1 | 2012 | 1 | 2013 | 2 | 2014 | 3 | 2015 | 2 | 2016 | 3 | 2017 | 3 | 2018 | 1 | 2019 | 5 | 2020 | 2 | 2021 | 6 | 2022 | 5 | 2023 | 2 | 2024 | 10 |
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