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Eric Enemark

TitleAssociate Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentBiochemistry & Molecular Biology, College of Medicine
Address405C BIOMED
4301 W. Markham
Mail Slot # 516
Little Rock AR 72205
Phone501-214-2445
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    Collapse Research 
    Collapse research activities and funding
    P20GM152281     (EOFF, ROBERT L)Mar 5, 2024 - Dec 31, 2028
    NIH
    Center for Molecular Interactions in Cancer (CMIC)
    Role: Co-Investigator
    R01AI169462 (subaward 5128306)     (CRAIG E. CAMERON)Apr 1, 2023 - Mar 31, 2024
    NIH/NIAID
    Enteroviral 2C protein as a therapeutic target
    Role: Principal Investigator
    R35GM136313     (ENEMARK, ERIC)Jun 1, 2020 - May 31, 2025
    NIH
    Molecular mechanisms of nucleic acid machines
    Role: Principal Investigator
    R01GM098771     (ENEMARK, ERIC)Aug 1, 2011 - Aug 31, 2021
    NIH
    Molecular mechanisms of DNA replication
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Osei B, May BH, Stiefel CM, West KL, Zafar MK, Thompson MD, Bergstrom E, Leung JW, Enemark EJ, Byrd AK. Rare SNP in the HELB gene interferes with RPA interaction and cellular function of HELB. bioRxiv. 2024 Mar 02. PMID: 38464108.
      View in: PubMed
    2. Meagher M, Myasnikov A, Enemark EJ. Two Distinct Modes of DNA Binding by an MCM Helicase Enable DNA Translocation. Int J Mol Sci. 2022 Nov 24; 23(23). PMID: 36499022.
      View in: PubMed
    3. Yeager C, Carter G, Gohara DW, Yennawar NH, Enemark EJ, Arnold JJ, Cameron CE. Enteroviral 2C protein is an RNA-stimulated ATPase and uses a two-step mechanism for binding to RNA and ATP. Nucleic Acids Res. 2022 11 11; 50(20):11775-11798. PMID: 36399514.
      View in: PubMed
    4. Meagher M, Spence MN, Enemark EJ. Structure of a dimer of the Sulfolobus solfataricus MCM N-terminal domain reveals a potential role in MCM ring opening. Acta Crystallogr F Struct Biol Commun. 2021 Jun 01; 77(Pt 6):177-186. PMID: 34100776.
      View in: PubMed
    5. Meagher M, Epling LB, Enemark EJ. DNA translocation mechanism of the MCM complex and implications for replication initiation. Nat Commun. 2019 07 15; 10(1):3117. PMID: 31308367.
      View in: PubMed
    6. Iacobucci I, Wen J, Meggendorfer M, Choi JK, Shi L, Pounds SB, Carmichael CL, Masih KE, Morris SM, Lindsley RC, Janke LJ, Alexander TB, Song G, Qu C, Li Y, Payne-Turner D, Tomizawa D, Kiyokawa N, Valentine M, Valentine V, Basso G, Locatelli F, Enemark EJ, Kham SKY, Yeoh AEJ, Ma X, Zhou X, Sioson E, Rusch M, Ries RE, Stieglitz E, Hunger SP, Wei AH, To LB, Lewis ID, D'Andrea RJ, Kile BT, Brown AL, Scott HS, Hahn CN, Marlton P, Pei D, Cheng C, Loh ML, Ebert BL, Meshinchi S, Haferlach T, Mullighan CG. Genomic subtyping and therapeutic targeting of acute erythroleukemia. Nat Genet. 2019 04; 51(4):694-704. PMID: 30926971.
      View in: PubMed
    7. Miller JM, Enemark EJ. Fundamental Characteristics of AAA+ Protein Family Structure and Function. Archaea. 2016; 2016:9294307. PMID: 27703410.
      View in: PubMed
    8. Meagher M, Enemark EJ. Structure of a double hexamer of the Pyrococcus furiosus minichromosome maintenance protein N-terminal domain. Acta Crystallogr F Struct Biol Commun. 2016 07; 72(Pt 7):545-51. PMID: 27380371.
      View in: PubMed
    9. Miller JM, Enemark EJ. Archaeal MCM Proteins as an Analog for the Eukaryotic Mcm2-7 Helicase to Reveal Essential Features of Structure and Function. Archaea. 2015; 2015:305497. PMID: 26539061.
      View in: PubMed
    10. Froelich CA, Nourse A, Enemark EJ. MCM ring hexamerization is a prerequisite for DNA-binding. Nucleic Acids Res. 2015 Oct 30; 43(19):9553-63. PMID: 26365238.
      View in: PubMed
    11. Epling LB, Grace CR, Lowe BR, Partridge JF, Enemark EJ. Cancer-associated mutants of RNA helicase DDX3X are defective in RNA-stimulated ATP hydrolysis. J Mol Biol. 2015 May 08; 427(9):1779-1796. PMID: 25724843.
      View in: PubMed
    12. Miller JM, Arachea BT, Epling LB, Enemark EJ. Analysis of the crystal structure of an active MCM hexamer. Elife. 2014 Sep 29; 3:e03433. PMID: 25262915.
      View in: PubMed
    13. Froelich CA, Kang S, Epling LB, Bell SP, Enemark EJ. A conserved MCM single-stranded DNA binding element is essential for replication initiation. Elife. 2014 Apr 01; 3:e01993. PMID: 24692448.
      View in: PubMed
    14. Lee SJ, Syed S, Enemark EJ, Schuck S, Stenlund A, Ha T, Joshua-Tor L. Dynamic look at DNA unwinding by a replicative helicase. Proc Natl Acad Sci U S A. 2014 Mar 04; 111(9):E827-35. PMID: 24550505.
      View in: PubMed
    15. Baker SD, Zimmerman EI, Wang YD, Orwick S, Zatechka DS, Buaboonnam J, Neale GA, Olsen SR, Enemark EJ, Shurtleff S, Rubnitz JE, Mullighan CG, Inaba H. Emergence of polyclonal FLT3 tyrosine kinase domain mutations during sequential therapy with sorafenib and sunitinib in FLT3-ITD-positive acute myeloid leukemia. Clin Cancer Res. 2013 Oct 15; 19(20):5758-68. PMID: 23969938.
      View in: PubMed
    16. Enemark EJ, Joshua-Tor L. On helicases and other motor proteins. Curr Opin Struct Biol. 2008 Apr; 18(2):243-57. PMID: 18329872.
      View in: PubMed
    17. Enemark EJ, Joshua-Tor L. Mechanism of DNA translocation in a replicative hexameric helicase. Nature. 2006 Jul 20; 442(7100):270-5. PMID: 16855583.
      View in: PubMed
    18. Tolia NH, Enemark EJ, Sim BK, Joshua-Tor L. Structural basis for the EBA-175 erythrocyte invasion pathway of the malaria parasite Plasmodium falciparum. Cell. 2005 Jul 29; 122(2):183-93. PMID: 16051144.
      View in: PubMed
    19. Enemark EJ, Stenlund A, Joshua-Tor L. Crystal structures of two intermediates in the assembly of the papillomavirus replication initiation complex. EMBO J. 2002 Mar 15; 21(6):1487-96. PMID: 11889054.
      View in: PubMed
    20. Enemark EJ, Chen G, Vaughn DE, Stenlund A, Joshua-Tor L. Crystal structure of the DNA binding domain of the replication initiation protein E1 from papillomavirus. Mol Cell. 2000 Jul; 6(1):149-58. PMID: 10949036.
      View in: PubMed
    21. Masood MA, Enemark EJ, Stack TDP. Ligand Self-Recognition in the Self-Assembly of a [{Cu(L)}2 ]2+ Complex: The Role of Chirality. Angew Chem Int Ed Engl. 1998 Apr 20; 37(7):928-932. PMID: 29711475.
      View in: PubMed
    22. Enemark EJ, Stack TDP. Stereospecificity and Self-Selectivity in the Generation of a Chiral Molecular Tetrahedron by Metal-Assisted Self-Assembly. Angew Chem Int Ed Engl. 1998 Apr 20; 37(7):932-935. PMID: 29711465.
      View in: PubMed
    23. Eric J. Enemark and T. D. P. Stack. Spectral and Structural Characterization of Two Ferric Coordination Modes of a Simple Bis(catecholamide) Ligand:? Metal-Assisted Self-Assembly in a Siderophore Analog. Inorganic Chemistry. 1996; 35(10):2719–2720.
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    24. Eric J. Enemark, Dr. T. D. P. Stack. Synthesis and Structural Characterization of a Stereospecific Dinuclear Gallium Triple Helix: Use of the trans-Influence in Metal-Assisted Self-Assembly. Angew. Chem. Int. Ed. Engl. 1995; 34(9):996-998.
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