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Shuk-Mei Ho

TitleVice Chancellor of Research & Innovation
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPharmacology and Toxicology, College of Medicine
Address200 South Cedar
Mail Slot # 718
Little Rock AR 72202
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    Collapse Research 
    Collapse research activities and funding
    T32GM150536     (PRATHER, PAUL L)Jul 1, 2023 - Jun 30, 2028
    NIH
    Training in Systems Pharmacology and Toxicology (T-SPaT)
    Role: Co-Investigator
    IK6BX006182     (HO, SHUK-MEI)Oct 1, 2022 - Sep 30, 2027
    NIH
    BLRD Research Career Scientist Award Application
    Role: Principal Investigator
    1IK6BX006182     (HO, SHUK-MEI)Oct 1, 2022 - Sep 1, 2027
    Veterans' Administration (VA HSRD)
    Research Career Scientist Award
    Role: Principal Investigator
    C06OD032002     (VOTH, DANIEL)Sep 19, 2022 - May 31, 2027
    NIH/Office of the Director
    Expanding UAMS Research Capacity to Investigate the Host Response to Infectious Disease
    Role: Principal Investigator
    Award #2217824     (HO, SHUK-MEI)Aug 1, 2022 - Jul 31, 2028
    National Science Foundation - Pass Through: Louisiana Tech University
    NSF, RII Track-2 FEC: Facilitating Ubiquitous Technology Utilizing Resilient Eco-friendly Sensors (FUTURE Sensors)
    Role: Principal Investigator
    W81XWH2210152     (HO, SHUK-MEI)May 1, 2022 - Apr 30, 2026
    US Department of Defense
    DNA methylation markers associated with exposure and adverse health outcomes in Veterans exposed to airborne hazards from open burn pits
    Role: Principal Investigator
    1R01ES032675-01A1     (HO, SHUK-MEI)Apr 29, 2022 - Jan 31, 2027
    NIH/Nat. Inst. of Environmental Health Sciences
    RNA modifications by paternal exposure to arsenic and intergenerational effects on sperm quality
    Role: Principal Investigator
    R01ES032675     (HO, SHUK-MEI)Apr 29, 2022 - Jan 31, 2027
    NIH
    RNA modifications by paternal exposure to arsenic and intergenerational effects on sperm quality
    Role: Principal Investigator
    R01 AR12345     (HO, SHUK-MEI)Jul 1, 2021 - Jun 30, 2026
    NIH/Nat. Cancer Institute - Pass Through: Mayo Clinic Arizona
    Test - Long Title
    Role: Principal Investigator
    I01BX005395     (HO, SHUK-MEI)Jul 1, 2021 - Jun 30, 2025
    Veterans' Administration (VA)
    Metal-induced cell-level changes in prostate epithelium and cancer risk
    Role: Principal Investigator
    I01BX005395     (HO, SHUK-MEI)Jul 1, 2021 - Jun 30, 2025
    NIH
    Metal-induced cell-level changes in prostate epithelium and cancer risk
    Role: Principal Investigator
    R01ES022071     (PRINS, GAIL S)Aug 23, 2012 - Apr 30, 2018
    NIH
    Effects of Arsenic on Human Prostate Stem Cells and Prostate Cancer Risk
    Role: Co-Principal Investigator
    U01ES020988     (HO, SHUK-MEI)Sep 19, 2011 - May 31, 2018
    NIH
    Chronic exposure to Biphenol A and uterine cancer risk markers
    Role: Principal Investigator
    U01ES019480     (HO, SHUK-MEI)Sep 22, 2010 - May 31, 2016
    NIH
    Susceptible Window of High Fat Diet/Bisphenol A Programming of Breast Cancer Risk
    Role: Principal Investigator
    C06RR028634     (HO, SHUK-MEI)Jan 7, 2010 - Jan 6, 2015
    NIH
    Kettering Lab Renovation to enhance PHS-supported environmental health research
    Role: Principal Investigator
    I01BX000675     (HO, SHUK-MEI)Oct 1, 2009 - Dec 31, 2019
    NIH
    Estrogen-based combinatorial therapies for castration-resistant prostate cancer
    Role: Principal Investigator
    RC2ES018789     (WALKER, CHERYL L.)Sep 24, 2009 - Jul 31, 2013
    NIH
    Developmental Reprogramming of Prostate Carcinogenesis by BPA
    Role: Co-Principal Investigator
    RC2ES018758     (PRINS, GAIL S)Sep 21, 2009 - Jun 30, 2012
    NIH
    Developmental Exposure to Low-dose Bisphenol A and Human Prostate Cancer Suscepti
    Role: Co-Principal Investigator
    R13DK083204     (HO, SHUK-MEI)Sep 15, 2008 - Aug 31, 2009
    NIH
    The 18th Annual Meeting of the SBUR: Epigenetics and GU Disorders
    Role: Principal Investigator
    R01ES015584     (PRINS, GAIL S)Jan 15, 2008 - Nov 30, 2013
    NIH
    Epigenetic Basis for Prostate Carcinogenesis following Early Estrogenic Exposures
    Role: Co-Principal Investigator
    R01CA112532     (HO, SHUK-MEI)Jul 1, 2006 - May 31, 2012
    NIH
    Hormone-induced inflammation and prostate cancer
    Role: Principal Investigator
    R01CA112570     (HO, SHUK-MEI)Sep 1, 2005 - May 31, 2011
    NIH
    Progesterone-mediated protection against ovarian cancer
    Role: Principal Investigator
    R21ES013071     (HO, SHUK-MEI)Jul 1, 2004 - Jun 30, 2008
    NIH
    Development Modulation of Mouse Uterine Tumorigenesis
    Role: Principal Investigator
    R01CA094221     (HO, SHUK-MEI)Jul 16, 2002 - Jun 30, 2007
    NIH
    CYP1A1, estrogen metabolism and ovarian carcinogenesis
    Role: Principal Investigator
    R01DK061084     (HO, SHUK-MEI)Sep 30, 2001 - Aug 31, 2006
    NIH
    Estrogen Receptor-beta and Prostate Function
    Role: Principal Investigator
    R13CA082786     (HO, SHUK-MEI)Jul 27, 1999 - Jul 26, 2000
    NIH
    GORDON CONFERENCE ON HORMONAL CARCINOGENESIS
    Role: Principal Investigator
    R13CA074864     (HO, SHUK-MEI)Jul 27, 1997 - Jul 26, 1998
    NIH
    GORDON CONFERENCE ON HORMONAL CARCINOGENESIS
    Role: Principal Investigator
    R01AG013965     (HO, SHUK-MEI)Mar 20, 1997 - Feb 28, 2003
    NIH
    TOXICANT OR AGING INDUCED OXIDATIVE STRESS IN PROSTATE
    Role: Principal Investigator
    R01HL056421     (HO, YE-SHIH)Aug 1, 1996 - Jul 31, 2002
    NIH
    NATURE OF LUNG ANTIOXIDANT DEFENSE MECHANISM
    Role: Principal Investigator
    R01CA062269     (HO, SHUK-MEI)Jul 1, 1995 - Aug 31, 2009
    NIH
    Metallothionein &Cadmium Carcinogenesis in the Prostate
    Role: Principal Investigator
    R01CA060923     (HO, SHUK-MEI)Aug 1, 1993 - Jul 31, 1996
    NIH
    MECHANISM OF HORMONAL CARCINOGENESIS IN THE RAT PROSTATE
    Role: Principal Investigator
    S15HD029884     (HO, SHUK-MEI)Sep 1, 1992 - Aug 31, 1993
    NIH
    SMALL INSTRUMENTATION GRANT
    Role: Principal Investigator
    S15HD028778     (HO, SHUK-MEI)Sep 1, 1991 - Aug 31, 1992
    NIH
    SMALL INSTRUMENTATION GRANT
    Role: Principal Investigator
    R01HL044571     (HO, SHUK-MEI)Apr 1, 1990 - May 31, 1996
    NIH
    TRANSGENIC MODELS FOR LUNG BIOLOGY AND DISEASE
    Role: Principal Investigator
    R01HL039585     (HO, SHUK-MEI)Sep 30, 1987 - Mar 31, 1999
    NIH
    SUPEROXIDE DISMUTASE GENE REGULATION IN LUNG INJURY
    Role: Principal Investigator
    S07RR007179     (HO, SHUK-MEI)Apr 1, 1979 - Sep 29, 1992
    NIH
    BIOMEDICAL RESEARCH SUPPORT
    Role: Principal Investigator
    R01CA015776     (HO, SHUK-MEI)Sep 30, 1978 - May 31, 2010
    NIH
    Prostatic Differentiation and Sex Hormone Metabolism
    Role: Principal Investigator
    P30ES006096     (PINNEY, SUSAN MENGEL)Mar 31, 2024
    NIH
    Center for Environmental Genetics
    Role: Co-Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Cortes-Ramirez SA, Ho SM, Leung YK. Endocrine-Disrupting Chemicals: A Looming Threat to Current and Future Generations. Int J Mol Sci. 2024 Jul 27; 25(15). PMID: 39125790.
      View in: PubMed
    2. Puvvula J, Braun JM, DeFranco EA, Ho SM, Leung YK, Huang S, Zhang X, Vuong AM, Kim SS, Percy Z, Calafat AM, Botelho JC, Chen A. Gestational exposure to environmental chemicals and epigenetic alterations in the placenta and cord blood mononuclear cells. Epigenetics Commun. 2024; 4(1):4. PMID: 38962689.
      View in: PubMed
    3. Leung YK, Lee SG, Wang J, Guruvaiah P, Rusch NJ, Ho SM, Park C, Kim K. The Loss of an Orphan Nuclear Receptor NR2E3 Augments Wnt/?-catenin Signaling via Epigenetic Dysregulation that Enhances Sp1-? catenin-p300 Interactions in Hepatocellular Carcinoma. Adv Sci (Weinh). 2024 Aug; 11(29):e2308539. PMID: 38790135.
      View in: PubMed
    4. Puvvula J, Manz KE, Braun JM, Pennell KD, DeFranco EA, Ho SM, Leung YK, Huang S, Vuong AM, Kim SS, Percy ZP, Bhashyam P, Lee R, Jones DP, Tran V, Kim DV, Chen A. Maternal and newborn metabolomic changes associated with urinary polycyclic aromatic hydrocarbon metabolite concentrations at delivery: an untargeted approach. Metabolomics. 2023 Dec 14; 20(1):6. PMID: 38095785.
      View in: PubMed
    5. Tu SM, Chen JZ, Singh SR, Aydin AM, Gokden N, Tam NNC, Leung YK, Langford T, Ho SM. Stem Cell Theory of Cancer: Clinical Implications of Epigenomic versus Genomic Biomarkers in Cancer Care. Cancers (Basel). 2023 Nov 22; 15(23). PMID: 38067237.
      View in: PubMed
    6. McDermott A, Kim K, Kasper S, Ho SM, Leung YK. The androgen receptor inhibits transcription of GPER1 by preventing Sp1 and Sp3 from binding to the promoters in prostate cancer cells. Oncotarget. 2022; 13:46-60. PMID: 35018219.
      View in: PubMed
    7. Ho SM, Rao R, Ouyang B, Tam NNC, Schoch E, Song D, Ying J, Leung YK, Govindarajah V, Tarapore P. Three-Generation Study of Male Rats Gestationally Exposed to High Butterfat and Bisphenol A: Impaired Spermatogenesis, Penetrance with Reduced Severity. Nutrients. 2021 Oct 17; 13(10). PMID: 34684636.
      View in: PubMed
    8. Padala KP, Padala PR, Leung YK, Dennis RA, Ho SM. Untangling the Complex Interactions of Open Burn Pit Exposure and Health Outcomes: Response to Brumage et al. Prim Care Companion CNS Disord. 2021 04 22; 23(2). PMID: 34000124.
      View in: PubMed
    9. Leung YK, Biesiada J, Govindarajah V, Ying J, Kendler A, Medvedovic M, Ho SM. Low-Dose Bisphenol A in a Rat Model of Endometrial Cancer: A CLARITY-BPA Study. Environ Health Perspect. 2020 12; 128(12):127005. PMID: 33296240.
      View in: PubMed
    10. Padala KP, Padala PR, Leung YK, Dennis RA, Ho SM. Open Burn Pit Exposure and Concern About the COVID-19 Pandemic. Prim Care Companion CNS Disord. 2020 11 05; 22(6). PMID: 33166097.
      View in: PubMed
    11. Heindel JJ, Belcher S, Flaws JA, Prins GS, Ho SM, Mao J, Patisaul HB, Ricke W, Rosenfeld CS, Soto AM, Vom Saal FS, Zoeller RT. Data integration, analysis, and interpretation of eight academic CLARITY-BPA studies. Reprod Toxicol. 2020 12; 98:29-60. PMID: 32682780.
      View in: PubMed
    12. Wongsurawat T, Jenjaroenpun P, De Loose A, Alkam D, Ussery DW, Nookaew I, Leung YK, Ho SM, Day JD, Rodriguez A. A novel Cas9-targeted long-read assay for simultaneous detection of IDH1/2 mutations and clinically relevant MGMT methylation in fresh biopsies of diffuse glioma. Acta Neuropathol Commun. 2020 06 20; 8(1):87. PMID: 32563269.
      View in: PubMed
    13. Lu Y, Liu X, Zhang E, Kopras EJ, Smith EP, Astreinidis A, Li C, Leung YK, Ho SM, Yu JJ. Estrogen activates pyruvate kinase M2 and increases the growth of TSC2-deficient cells. PLoS One. 2020; 15(2):e0228894. PMID: 32078667.
      View in: PubMed
    14. Khanal T, Leung YK, Jiang W, Timchenko N, Ho SM, Kim K. NR2E3 is a key component in p53 activation by regulating a long noncoding RNA DINO in acute liver injuries. FASEB J. 2019 07; 33(7):8335-8348. PMID: 30991008.
      View in: PubMed
    15. Xie C, Leung YK, Chen A, Long DX, Hoyo C, Ho SM. Differential methylation values in differential methylation analysis. Bioinformatics. 2019 04 01; 35(7):1094-1097. PMID: 30184051.
      View in: PubMed
    16. Leung YK, Chan QK, Ng CF, Ma FM, Tse HM, To KF, Maranchie J, Ho SM, Lau KM. Correction: Hsa-miRNA-765 as a Key Mediator for Inhibiting Growth, Migration and Invasion in Fulvestrant-Treated Prostate Cancer. PLoS One. 2019; 14(3):e0214184. PMID: 30883603.
      View in: PubMed
    17. Dworatzek E, Mahmoodzadeh S, Schriever C, Kusumoto K, Kramer L, Santos G, Fliegner D, Leung YK, Ho SM, Zimmermann WH, Lutz S, Regitz-Zagrosek V. Sex-specific regulation of collagen I and III expression by 17?-Estradiol in cardiac fibroblasts: role of estrogen receptors. Cardiovasc Res. 2019 02 01; 115(2):315-327. PMID: 30016401.
      View in: PubMed
    18. Cheong A, Johnson SA, Howald EC, Ellersieck MR, Camacho L, Lewis SM, Vanlandingham MM, Ying J, Ho SM, Rosenfeld CS. Gene expression and DNA methylation changes in the hypothalamus and hippocampus of adult rats developmentally exposed to bisphenol A or ethinyl estradiol: a CLARITY-BPA consortium study. Epigenetics. 2018; 13(7):704-720. PMID: 30001178.
      View in: PubMed
    19. Leung YK, Ouyang B, Niu L, Xie C, Ying J, Medvedovic M, Chen A, Weihe P, Valvi D, Grandjean P, Ho SM. Identification of sex-specific DNA methylation changes driven by specific chemicals in cord blood in a Faroese birth cohort. Epigenetics. 2018; 13(3):290-300. PMID: 29560787.
      View in: PubMed
    20. Zhang Y, Xu X, Chen A, Davuljigari CB, Zheng X, Kim SS, Dietrich KN, Ho SM, Reponen T, Huo X. Maternal urinary cadmium levels during pregnancy associated with risk of sex-dependent birth outcomes from an e-waste pollution site in China. Reprod Toxicol. 2018 01; 75:49-55. PMID: 29154917.
      View in: PubMed
    21. Khanal T, Choi K, Leung YK, Wang J, Kim D, Janakiram V, Cho SG, Puga A, Ho SM, Kim K. Loss of NR2E3 represses AHR by LSD1 reprogramming, is associated with poor prognosis in liver cancer. Sci Rep. 2017 09 06; 7(1):10662. PMID: 28878246.
      View in: PubMed
    22. Prins GS, Ye SH, Birch L, Zhang X, Cheong A, Lin H, Calderon-Gierszal E, Groen J, Hu WY, Ho SM, van Breemen RB. Prostate Cancer Risk and DNA Methylation Signatures in Aging Rats following Developmental BPA Exposure: A Dose-Response Analysis. Environ Health Perspect. 2017 07 11; 125(7):077007. PMID: 28728135.
      View in: PubMed
    23. Chen T, Lu L, Xu C, Lin X, Leung YK, Ho SM, Ruan XZ, Lian X. Inhibition Role of Atherogenic Diet on Ethyl Carbamate Induced Lung Tumorigenesis in C57BL/6J Mice. Sci Rep. 2017 07 05; 7(1):4723. PMID: 28680122.
      View in: PubMed
    24. Sharma M, Zhang X, Zhang S, Niu L, Ho SM, Chen A, Huang S. Inhibition of endocytic lipid antigen presentation by common lipophilic environmental pollutants. Sci Rep. 2017 05 18; 7(1):2085. PMID: 28522830.
      View in: PubMed
    25. Leung YK, Govindarajah V, Cheong A, Veevers J, Song D, Gear R, Zhu X, Ying J, Kendler A, Medvedovic M, Belcher S, Ho SM. Gestational high-fat diet and bisphenol A exposure heightens mammary cancer risk. Endocr Relat Cancer. 2017 07; 24(7):365-378. PMID: 28487351.
      View in: PubMed
    26. Smithrud DB, Powers L, Lunn J, Abernathy S, Peschka M, Ho SM, Tarapore P. Ca2+ Selective Host Rotaxane Is Highly Toxic Against Prostate Cancer Cells. ACS Med Chem Lett. 2017 Feb 09; 8(2):163-167. PMID: 28197305.
      View in: PubMed
    27. Ho SM, Rao R, To S, Schoch E, Tarapore P. Bisphenol A and its analogues disrupt centrosome cycle and microtubule dynamics in prostate cancer. Endocr Relat Cancer. 2017 02; 24(2):83-96. PMID: 27998958.
      View in: PubMed
    28. Tarapore P, Hennessy M, Song D, Ying J, Ouyang B, Govindarajah V, Leung YK, Ho SM. Data on spermatogenesis in rat males gestationally exposed to bisphenol A and high fat diets. Data Brief. 2016 Dec; 9:812-817. PMID: 27872877.
      View in: PubMed
    29. Tarapore P, Hennessy M, Song D, Ying J, Ouyang B, Govindarajah V, Leung YK, Ho SM. High butter-fat diet and bisphenol A additively impair male rat spermatogenesis. Reprod Toxicol. 2017 03; 68:191-199. PMID: 27658648.
      View in: PubMed
    30. Xu Z, Taylor JA, Leung YK, Ho SM, Niu L. oxBS-MLE: an efficient method to estimate 5-methylcytosine and 5-hydroxymethylcytosine in paired bisulfite and oxidative bisulfite treated DNA. Bioinformatics. 2016 12 01; 32(23):3667-3669. PMID: 27522082.
      View in: PubMed
    31. Ehrlich S, Lambers D, Baccarelli A, Khoury J, Macaluso M, Ho SM. Endocrine Disruptors: A Potential Risk Factor for Gestational Diabetes Mellitus. Am J Perinatol. 2016 11; 33(13):1313-1318. PMID: 27490770.
      View in: PubMed
    32. Cheong A, Zhang X, Cheung YY, Tang WY, Chen J, Ye SH, Medvedovic M, Leung YK, Prins GS, Ho SM. DNA methylome changes by estradiol benzoate and bisphenol A links early-life environmental exposures to prostate cancer risk. Epigenetics. 2016 09; 11(9):674-689. PMID: 27415467.
      View in: PubMed
    33. Ho SM, Cheong A, Adgent MA, Veevers J, Suen AA, Tam NNC, Leung YK, Jefferson WN, Williams CJ. Environmental factors, epigenetics, and developmental origin of reproductive disorders. Reprod Toxicol. 2017 03; 68:85-104. PMID: 27421580.
      View in: PubMed
    34. Rizzardi AE, Zhang X, Vogel RI, Kolb S, Geybels MS, Leung YK, Henriksen JC, Ho SM, Kwak J, Stanford JL, Schmechel SC. Quantitative comparison and reproducibility of pathologist scoring and digital image analysis of estrogen receptor ?2 immunohistochemistry in prostate cancer. Diagn Pathol. 2016 Jul 11; 11(1):63. PMID: 27401406.
      View in: PubMed
    35. Wang Q, Trevino LS, Wong RL, Medvedovic M, Chen J, Ho SM, Shen J, Foulds CE, Coarfa C, O'Malley BW, Shilatifard A, Walker CL. Reprogramming of the Epigenome by MLL1 Links Early-Life Environmental Exposures to Prostate Cancer Risk. Mol Endocrinol. 2016 Aug; 30(8):856-71. PMID: 27219490.
      View in: PubMed
    36. Miller M, Bailey B, Govindarajah V, Levin L, Metzger T, Pinney SM, Leung YK, Ho SM. A community survey on knowledge of the impact of environmental and epigenetic factors on health and disease. Perspect Public Health. 2016 Nov; 136(6):345-352. PMID: 26941233.
      View in: PubMed
    37. Schade GR, Holt SK, Zhang X, Song D, Wright JL, Zhao S, Kolb S, Lam HM, Levin L, Leung YK, Ho SM, Stanford JL. Prostate Cancer Expression Profiles of Cytoplasmic ER?1 and Nuclear ER?2 are Associated with Poor Outcomes following Radical Prostatectomy. J Urol. 2016 06; 195(6):1760-6. PMID: 26804755.
      View in: PubMed
    38. Govindarajah V, Leung YK, Ying J, Gear R, Bornschein RL, Medvedovic M, Ho SM. In utero exposure of rats to high-fat diets perturbs gene expression profiles and cancer susceptibility of prepubertal mammary glands. J Nutr Biochem. 2016 Mar; 29:73-82. PMID: 26895667.
      View in: PubMed
    39. Ho SM, Tam NN. Organoid model shows effect of BPA on prostate development. Nat Rev Urol. 2015 Dec; 12(12):658-9. PMID: 26526756.
      View in: PubMed
    40. Martinez AM, Cheong A, Ying J, Xue J, Kannan K, Leung YK, Thomas MA, Ho SM. Effects of High-Butterfat Diet on Embryo Implantation in Female Rats Exposed to Bisphenol A. Biol Reprod. 2015 Dec; 93(6):147. PMID: 26510865.
      View in: PubMed
    41. Lam HM, Ho SM, Chen J, Medvedovic M, Tam NN. Bisphenol A Disrupts HNF4a-Regulated Gene Networks Linking to Prostate Preneoplasia and Immune Disruption in Noble Rats. Endocrinology. 2016 Jan; 157(1):207-19. PMID: 26496021.
      View in: PubMed
    42. Seachrist DD, Bonk KW, Ho SM, Prins GS, Soto AM, Keri RA. A review of the carcinogenic potential of bisphenol A. Reprod Toxicol. 2016 Jan; 59:167-82. PMID: 26493093.
      View in: PubMed
    43. Panchanathan R, Liu H, Leung YK, Ho SM, Choubey D. Bisphenol A (BPA) stimulates the interferon signaling and activates the inflammasome activity in myeloid cells. Mol Cell Endocrinol. 2015 Nov 05; 415:45-55. PMID: 26277401.
      View in: PubMed
    44. Ho SM, Cheong A, Lam HM, Hu WY, Shi GB, Zhu X, Chen J, Zhang X, Medvedovic M, Leung YK, Prins GS. Exposure of Human Prostaspheres to Bisphenol A Epigenetically Regulates SNORD Family Noncoding RNAs via Histone Modification. Endocrinology. 2015 Nov; 156(11):3984-95. PMID: 26248216.
      View in: PubMed
    45. Paquette IM, Ying J, Shah SA, Abbott DE, Ho SM. African Americans should be screened at an earlier age for colorectal cancer. Gastrointest Endosc. 2015 Nov; 82(5):878-83. PMID: 25952088.
      View in: PubMed
    46. Tam NN, Zhang X, Xiao H, Song D, Levin L, Meller J, Ho SM. Increased susceptibility of estrogen-induced bladder outlet obstruction in a novel mouse model. Lab Invest. 2015 May; 95(5):546-60. PMID: 25706094.
      View in: PubMed
    47. Wong RL, Wang Q, Trevi?o LS, Bosland MC, Chen J, Medvedovic M, Prins GS, Kannan K, Ho SM, Walker CL. Identification of secretaglobin Scgb2a1 as a target for developmental reprogramming by BPA in the rat prostate. Epigenetics. 2015; 10(2):127-34. PMID: 25612011.
      View in: PubMed
    48. Yang WS, Chadalapaka G, Cho SG, Lee SO, Jin UH, Jutooru I, Choi K, Leung YK, Ho SM, Safe S, Kim K. The transcriptional repressor ZBTB4 regulates EZH2 through a MicroRNA-ZBTB4-specificity protein signaling axis. Neoplasia. 2014 Dec; 16(12):1059-69. PMID: 25499219.
      View in: PubMed
    49. Lam HM, Ouyang B, Chen J, Ying J, Wang J, Wu CL, Jia L, Medvedovic M, Vessella RL, Ho SM. Targeting GPR30 with G-1: a new therapeutic target for castration-resistant prostate cancer. Endocr Relat Cancer. 2014; 21(6):903-14. PMID: 25287069.
      View in: PubMed
    50. Ho SM. Battle against the odds: win with effort, attitude, and perseverance! Endocr Relat Cancer. 2014 Aug; 21(4):P19-24. PMID: 24928923.
      View in: PubMed
    51. Leung YK, Chan QK, Ng CF, Ma FM, Tse HM, To KF, Maranchie J, Ho SM, Lau KM. Hsa-miRNA-765 as a key mediator for inhibiting growth, migration and invasion in fulvestrant-treated prostate cancer. PLoS One. 2014; 9(5):e98037. PMID: 24837491.
      View in: PubMed
    52. Knower KC, To SQ, Leung YK, Ho SM, Clyne CD. Endocrine disruption of the epigenome: a breast cancer link. Endocr Relat Cancer. 2014 Apr; 21(2):T33-55. PMID: 24532474.
      View in: PubMed
    53. Tarapore P, Ying J, Ouyang B, Burke B, Bracken B, Ho SM. Exposure to bisphenol A correlates with early-onset prostate cancer and promotes centrosome amplification and anchorage-independent growth in vitro. PLoS One. 2014; 9(3):e90332. PMID: 24594937.
      View in: PubMed
    54. Langevin SM, Pinney SM, Leung YK, Ho SM. Does epigenetic drift contribute to age-related increases in breast cancer risk? Epigenomics. 2014; 6(4):367-9. PMID: 25333845.
      View in: PubMed
    55. Prins GS, Hu WY, Shi GB, Hu DP, Majumdar S, Li G, Huang K, Nelles JL, Ho SM, Walker CL, Kajdacsy-Balla A, van Breemen RB. Bisphenol A promotes human prostate stem-progenitor cell self-renewal and increases in vivo carcinogenesis in human prostate epithelium. Endocrinology. 2014 Mar; 155(3):805-17. PMID: 24424067.
      View in: PubMed
    56. Lee MT, Ho SM, Tarapore P, Chung I, Leung YK. Estrogen receptor ? isoform 5 confers sensitivity of breast cancer cell lines to chemotherapeutic agent-induced apoptosis through interaction with Bcl2L12. Neoplasia. 2013 Nov; 15(11):1262-71. PMID: 24339738.
      View in: PubMed
    57. Lee MT, Leung YK, Chung I, Tarapore P, Ho SM. Estrogen receptor ? (ER?1) transactivation is differentially modulated by the transcriptional coregulator Tip60 in a cis-acting element-dependent manner. J Biol Chem. 2013 Aug 30; 288(35):25038-25052. PMID: 23857583.
      View in: PubMed
    58. Lee MT, Ouyang B, Ho SM, Leung YK. Differential expression of estrogen receptor beta isoforms in prostate cancer through interplay between transcriptional and translational regulation. Mol Cell Endocrinol. 2013 Aug 25; 376(1-2):125-35. PMID: 23806560.
      View in: PubMed
    59. Ouyang B, Bernstein DI, Lummus ZL, Ying J, Boulet LP, Cartier A, Gautrin D, Ho SM. Interferon-? promoter is hypermethylated in blood DNA from workers with confirmed diisocyanate asthma. Toxicol Sci. 2013 Jun; 133(2):218-24. PMID: 23535363.
      View in: PubMed
    60. Brunst KJ, Leung YK, Ryan PH, Khurana Hershey GK, Levin L, Ji H, Lemasters GK, Ho SM. Forkhead box protein 3 (FOXP3) hypermethylation is associated with diesel exhaust exposure and risk for childhood asthma. J Allergy Clin Immunol. 2013 Feb; 131(2):592-4.e1-3. PMID: 23260754.
      View in: PubMed
    61. Jin C, Chen J, Meng Q, Carreira V, Tam NN, Geh E, Karyala S, Ho SM, Zhou X, Medvedovic M, Xia Y. Deciphering gene expression program of MAP3K1 in mouse eyelid morphogenesis. Dev Biol. 2013 Feb 01; 374(1):96-107. PMID: 23201579.
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    62. Isaac J, Tarapore P, Zhang X, Lam YW, Ho SM. Site-specific S-nitrosylation of integrin a6 increases the extent of prostate cancer cell migration by enhancing integrin ?1 association and weakening adherence to laminin-1. Biochemistry. 2012 Dec 04; 51(48):9689-97. PMID: 23106339.
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    63. Smithrud DB, Wang X, Tarapore P, Ho SM. Crown Ether Host-Rotaxanes as Cytotoxic Agents. ACS Med Chem Lett. 2013 Jan 10; 4(1):27-31. PMID: 23538490.
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    64. Privette Vinnedge LM, Ho SM, Wikenheiser-Brokamp KA, Wells SI. The DEK oncogene is a target of steroid hormone receptor signaling in breast cancer. PLoS One. 2012; 7(10):e46985. PMID: 23071688.
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    65. Ouyang B, Baxter CS, Lam HM, Yeramaneni S, Levin L, Haynes E, Ho SM. Hypomethylation of dual specificity phosphatase 22 promoter correlates with duration of service in firefighters and is inducible by low-dose benzo[a]pyrene. J Occup Environ Med. 2012 Jul; 54(7):774-80. PMID: 22796920.
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    66. Walker CL, Ho SM. Developmental reprogramming of cancer susceptibility. Nat Rev Cancer. 2012 Jun 14; 12(7):479-86. PMID: 22695395.
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    67. Leung YK, Lee MT, Lam HM, Tarapore P, Ho SM. Estrogen receptor-beta and breast cancer: translating biology into clinical practice. Steroids. 2012 Jun; 77(7):727-37. PMID: 22465878.
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    68. Lam HM, Suresh Babu CV, Wang J, Yuan Y, Lam YW, Ho SM, Leung YK. Phosphorylation of human estrogen receptor-beta at serine 105 inhibits breast cancer cell migration and invasion. Mol Cell Endocrinol. 2012 Jul 06; 358(1):27-35. PMID: 22370157.
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    69. Ho SM, Johnson A, Tarapore P, Janakiram V, Zhang X, Leung YK. Environmental epigenetics and its implication on disease risk and health outcomes. ILAR J. 2012; 53(3-4):289-305. PMID: 23744968.
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    70. Tang WY, Morey LM, Cheung YY, Birch L, Prins GS, Ho SM. Neonatal exposure to estradiol/bisphenol A alters promoter methylation and expression of Nsbp1 and Hpcal1 genes and transcriptional programs of Dnmt3a/b and Mbd2/4 in the rat prostate gland throughout life. Endocrinology. 2012 Jan; 153(1):42-55. PMID: 22109888.
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    71. Ho SM, Lee MT, Lam HM, Leung YK. Estrogens and prostate cancer: etiology, mediators, prevention, and management. Endocrinol Metab Clin North Am. 2011 Sep; 40(3):591-614, ix. PMID: 21889723.
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    72. Leung YK, Ho SM. Estrogen receptor ?: switching to a new partner and escaping from estrogen. Sci Signal. 2011 Apr 12; 4(168):pe19. PMID: 21487104.
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    73. Hu WY, Shi GB, Lam HM, Hu DP, Ho SM, Madueke IC, Kajdacsy-Balla A, Prins GS. Estrogen-initiated transformation of prostate epithelium derived from normal human prostate stem-progenitor cells. Endocrinology. 2011 Jun; 152(6):2150-63. PMID: 21427218.
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    74. Zhang X, Ho SM. Epigenetics meets endocrinology. J Mol Endocrinol. 2011 Feb; 46(1):R11-32. PMID: 21322125.
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    75. Zhou Q, Ching AK, Leung WK, Szeto CY, Ho SM, Chan PK, Yuan YF, Lai PB, Yeo W, Wong N. Novel therapeutic potential in targeting microtubules by nanoparticle albumin-bound paclitaxel in hepatocellular carcinoma. Int J Oncol. 2011 Mar; 38(3):721-31. PMID: 21240457.
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    76. Ouyang B, Leung YK, Wang V, Chung E, Levin L, Bracken B, Cheng L, Ho SM. a-Methylacyl-CoA racemase spliced variants and their expression in normal and malignant prostate tissues. Urology. 2011 Jan; 77(1):249.e1-7. PMID: 21195844.
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    77. Tarapore P, Shu Y, Guo P, Ho SM. Application of phi29 motor pRNA for targeted therapeutic delivery of siRNA silencing metallothionein-IIA and survivin in ovarian cancers. Mol Ther. 2011 Feb; 19(2):386-94. PMID: 21063391.
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    78. Prins GS, Ye SH, Birch L, Ho SM, Kannan K. Serum bisphenol A pharmacokinetics and prostate neoplastic responses following oral and subcutaneous exposures in neonatal Sprague-Dawley rats. Reprod Toxicol. 2011 Jan; 31(1):1-9. PMID: 20887781.
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    79. Tam NN, Szeto CY, Freudenberg JM, Fullenkamp AN, Medvedovic M, Ho SM. Research resource: estrogen-driven prolactin-mediated gene-expression networks in hormone-induced prostatic intraepithelial neoplasia. Mol Endocrinol. 2010 Nov; 24(11):2207-17. PMID: 20861223.
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    80. Leung YK, Lam HM, Wu S, Song D, Levin L, Cheng L, Wu CL, Ho SM. Estrogen receptor beta2 and beta5 are associated with poor prognosis in prostate cancer, and promote cancer cell migration and invasion. Endocr Relat Cancer. 2010 Sep; 17(3):675-89. PMID: 20501637.
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    81. Panchanathan R, Shen H, Zhang X, Ho SM, Choubey D. Mutually positive regulatory feedback loop between interferons and estrogen receptor-alpha in mice: implications for sex bias in autoimmunity. PLoS One. 2010 May 28; 5(5):e10868. PMID: 20526365.
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    82. Zhang X, Wu M, Xiao H, Lee MT, Levin L, Leung YK, Ho SM. Methylation of a single intronic CpG mediates expression silencing of the PMP24 gene in prostate cancer. Prostate. 2010 May 15; 70(7):765-76. PMID: 20054818.
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    83. Zhao H, Ou-Yang F, Chen IF, Hou MF, Yuan SS, Chang HL, Lee YC, Plattner R, Waltz SE, Ho SM, Sims J, Wang SC. Enhanced resistance to tamoxifen by the c-ABL proto-oncogene in breast cancer. Neoplasia. 2010 Mar; 12(3):214-23. PMID: 20234815.
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    84. Ouyang B, Bracken B, Burke B, Chung E, Liang J, Ho SM. A duplex quantitative polymerase chain reaction assay based on quantification of alpha-methylacyl-CoA racemase transcripts and prostate cancer antigen 3 in urine sediments improved diagnostic accuracy for prostate cancer. J Urol. 2009 Jun; 181(6):2508-13; discussion 2513-4. PMID: 19371911.
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    85. Perera F, Tang WY, Herbstman J, Tang D, Levin L, Miller R, Ho SM. Relation of DNA methylation of 5'-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma. PLoS One. 2009; 4(2):e4488. PMID: 19221603.
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    86. Myers JP, vom Saal FS, Akingbemi BT, Arizono K, Belcher S, Colborn T, Chahoud I, Crain DA, Farabollini F, Guillette LJ, Hassold T, Ho SM, Hunt PA, Iguchi T, Jobling S, Kanno J, Laufer H, Marcus M, McLachlan JA, Nadal A, Oehlmann J, Olea N, Palanza P, Parmigiani S, Rubin BS, Schoenfelder G, Sonnenschein C, Soto AM, Talsness CE, Taylor JA, Vandenberg LN, Vandenbergh JG, Vogel S, Watson CS, Welshons WV, Zoeller RT. Why public health agencies cannot depend on good laboratory practices as a criterion for selecting data: the case of bisphenol A. Environ Health Perspect. 2009 Mar; 117(3):309-15. PMID: 19337501.
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    87. Crain DA, Janssen SJ, Edwards TM, Heindel J, Ho SM, Hunt P, Iguchi T, Juul A, McLachlan JA, Schwartz J, Skakkebaek N, Soto AM, Swan S, Walker C, Woodruff TK, Woodruff TJ, Giudice LC, Guillette LJ. Female reproductive disorders: the roles of endocrine-disrupting compounds and developmental timing. Fertil Steril. 2008 Oct; 90(4):911-40. PMID: 18929049.
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    88. Lam YW, Tam NN, Evans JE, Green KM, Zhang X, Ho SM. Differential proteomics in the aging Noble rat ventral prostate. Proteomics. 2008 Jul; 8(13):2750-63. PMID: 18546156.
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    89. Bakshi S, Zhang X, Godoy-Tundidor S, Cheng RY, Sartor MA, Medvedovic M, Ho SM. Transcriptome analyses in normal prostate epithelial cells exposed to low-dose cadmium: oncogenic and immunomodulations involving the action of tumor necrosis factor. Environ Health Perspect. 2008 Jun; 116(6):769-76. PMID: 18560533.
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    90. Prins GS, Tang WY, Belmonte J, Ho SM. Perinatal exposure to oestradiol and bisphenol A alters the prostate epigenome and increases susceptibility to carcinogenesis. Basic Clin Pharmacol Toxicol. 2008 Feb; 102(2):134-8. PMID: 18226066.
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    91. Prins GS, Tang WY, Belmonte J, Ho SM. Developmental exposure to bisphenol A increases prostate cancer susceptibility in adult rats: epigenetic mode of action is implicated. Fertil Steril. 2008 Feb; 89(2 Suppl):e41. PMID: 18308059.
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    92. Miller RL, Ho SM. Environmental epigenetics and asthma: current concepts and call for studies. Am J Respir Crit Care Med. 2008 Mar 15; 177(6):567-73. PMID: 18187692.
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    93. Tam NN, Szeto CY, Sartor MA, Medvedovic M, Ho SM. Gene expression profiling identifies lobe-specific and common disruptions of multiple gene networks in testosterone-supported, 17beta-estradiol- or diethylstilbestrol-induced prostate dysplasia in Noble rats. Neoplasia. 2008 Jan; 10(1):20-40. PMID: 18231636.
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    94. Tam NN, Ho SM. Culture of whole embryonic kidneys: present status and beyond. J Urol. 2008 Jan; 179(1):17. PMID: 17997421.
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    95. Hess-Wilson JK, Webb SL, Daly HK, Leung YK, Boldison J, Comstock CE, Sartor MA, Ho SM, Knudsen KE. Unique bisphenol A transcriptome in prostate cancer: novel effects on ERbeta expression that correspond to androgen receptor mutation status. Environ Health Perspect. 2007 Nov; 115(11):1646-53. PMID: 18007998.
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    96. Tam NN, Leav I, Ho SM. Sex hormones induce direct epithelial and inflammation-mediated oxidative/nitrosative stress that favors prostatic carcinogenesis in the noble rat. Am J Pathol. 2007 Oct; 171(4):1334-41. PMID: 17717140.
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    97. vom Saal FS, Akingbemi BT, Belcher SM, Birnbaum LS, Crain DA, Eriksen M, Farabollini F, Guillette LJ, Hauser R, Heindel JJ, Ho SM, Hunt PA, Iguchi T, Jobling S, Kanno J, Keri RA, Knudsen KE, Laufer H, LeBlanc GA, Marcus M, McLachlan JA, Myers JP, Nadal A, Newbold RR, Olea N, Prins GS, Richter CA, Rubin BS, Sonnenschein C, Soto AM, Talsness CE, Vandenbergh JG, Vandenberg LN, Walser-Kuntz DR, Watson CS, Welshons WV, Wetherill Y, Zoeller RT. Chapel Hill bisphenol A expert panel consensus statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure. Reprod Toxicol. 2007 Aug-Sep; 24(2):131-8. PMID: 17768031.
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    98. Keri RA, Ho SM, Hunt PA, Knudsen KE, Soto AM, Prins GS. An evaluation of evidence for the carcinogenic activity of bisphenol A. Reprod Toxicol. 2007 Aug-Sep; 24(2):240-52. PMID: 17706921.
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    99. Ho SM, Tang WY. Techniques used in studies of epigenome dysregulation due to aberrant DNA methylation: an emphasis on fetal-based adult diseases. Reprod Toxicol. 2007 Apr-May; 23(3):267-82. PMID: 17317097.
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    100. Ho SM, Leung YK, Chung I. Estrogens and antiestrogens as etiological factors and therapeutics for prostate cancer. Ann N Y Acad Sci. 2006 Nov; 1089:177-93. PMID: 17261766.
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    101. Mak P, Leung YK, Tang WY, Harwood C, Ho SM. Apigenin suppresses cancer cell growth through ERbeta. Neoplasia. 2006 Nov; 8(11):896-904. PMID: 17132221.
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    102. Prins GS, Birch L, Tang WY, Ho SM. Developmental estrogen exposures predispose to prostate carcinogenesis with aging. Reprod Toxicol. 2007 Apr-May; 23(3):374-82. PMID: 17123779.
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    103. Leung YK, Mak P, Hassan S, Ho SM. Estrogen receptor (ER)-beta isoforms: a key to understanding ER-beta signaling. Proc Natl Acad Sci U S A. 2006 Aug 29; 103(35):13162-7. PMID: 16938840.
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    104. Ho SM, Tang WY, Belmonte de Frausto J, Prins GS. Developmental exposure to estradiol and bisphenol A increases susceptibility to prostate carcinogenesis and epigenetically regulates phosphodiesterase type 4 variant 4. Cancer Res. 2006 Jun 01; 66(11):5624-32. PMID: 16740699.
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    105. Leung YK, Gao Y, Lau KM, Zhang X, Ho SM. ICI 182,780-regulated gene expression in DU145 prostate cancer cells is mediated by estrogen receptor-beta/NFkappaB crosstalk. Neoplasia. 2006 Apr; 8(4):242-9. PMID: 16756716.
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    106. Tam NN, Nyska A, Maronpot RR, Kissling G, Lomnitski L, Suttie A, Bakshi S, Bergman M, Grossman S, Ho SM. Differential attenuation of oxidative/nitrosative injuries in early prostatic neoplastic lesions in TRAMP mice by dietary antioxidants. Prostate. 2006 Jan 01; 66(1):57-69. PMID: 16114064.
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    107. Leung YK, Lau KM, Mobley J, Jiang Z, Ho SM. Overexpression of cytochrome P450 1A1 and its novel spliced variant in ovarian cancer cells: alternative subcellular enzyme compartmentation may contribute to carcinogenesis. Cancer Res. 2005 May 01; 65(9):3726-34. PMID: 15867368.
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    108. Zhu X, Leav I, Leung YK, Wu M, Liu Q, Gao Y, McNeal JE, Ho SM. Dynamic regulation of estrogen receptor-beta expression by DNA methylation during prostate cancer development and metastasis. Am J Pathol. 2004 Jun; 164(6):2003-12. PMID: 15161636.
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    109. Tam NN, Gao Y, Leung YK, Ho SM. Androgenic regulation of oxidative stress in the rat prostate: involvement of NAD(P)H oxidases and antioxidant defense machinery during prostatic involution and regrowth. Am J Pathol. 2003 Dec; 163(6):2513-22. PMID: 14633623.
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    110. Kwong J, Lui K, Chan PS, Ho SM, Wong YC, Xuan JW, Chan FL. Expression study of three secretory proteins (prostatic secretory protein of 94 amino acids, probasin, and seminal vesicle secretion II) in dysplastic and neoplastic rat prostates. Prostate. 2003 Jul 01; 56(2):81-97. PMID: 12746832.
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    111. Lau KM, Tam NN, Thompson C, Cheng RY, Leung YK, Ho SM. Age-associated changes in histology and gene-expression profile in the rat ventral prostate. Lab Invest. 2003 May; 83(5):743-57. PMID: 12746483.
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    112. Tam NN, Ghatak S, Ho SM. Sex hormone-induced alterations in the activities of antioxidant enzymes and lipid peroxidation status in the prostate of Noble rats. Prostate. 2003 Apr 01; 55(1):1-8. PMID: 12640655.
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    113. Thompson CJ, Tam NN, Joyce JM, Leav I, Ho SM. Gene expression profiling of testosterone and estradiol-17 beta-induced prostatic dysplasia in Noble rats and response to the antiestrogen ICI 182,780. Endocrinology. 2002 Jun; 143(6):2093-105. PMID: 12021174.
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    114. Melnick R, Lucier G, Wolfe M, Hall R, Stancel G, Prins G, Gallo M, Reuhl K, Ho SM, Brown T, Moore J, Leakey J, Haseman J, Kohn M. Summary of the National Toxicology Program's report of the endocrine disruptors low-dose peer review. Environ Health Perspect. 2002 Apr; 110(4):427-31. PMID: 11940462.
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