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Ping-Ching Hsu

TitleAssociate Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentEnvironmental Health Sciences, College of Public Health
DivisionEnvironmental Health Sciences
Address220 UAMS Campus Dr.
Mail Slot # 820
Little Rock AR 72205
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    Collapse Overview 

    Collapse Affiliation 
    Collapse member of
    Metabolomics Society
    American Association for Cancer Research (AACR)
    Metabolomics Association of North America (MANA)

    Collapse Teaching 

    Collapse Research 
    Collapse research overview
    My laboratory is interested in biomarker discovery using global metabolite profiling (metabolomics). We use metabolomics to identify the “metabotype” that are consisting of oxidized lipids and metabolites in patients and animal models hoping to find early indicators of chemotherapy-induced cardiotoxicity and cognitive impairments in breast cancer patients. We also work on addressing the issue of cigarette smoking especially menthol cigarette smoking that’s contributing to the disparity of lethal prostate cancer in African-Americans, by identifying smoking-related metabolomics patterns associated with highly aggressive prostate cancer in African-Americans compared to European-Americans.

    Collapse research activities and funding
    W81XWH-21-1-0226     (Ping-Ching Hsu)Apr 1, 2021 - Mar 31, 2024
    US Department of Defense
    Metabolomics of Menthol Cigarette Smoking and Risk for Aggressive Prostate Cancer Among African American Men
    Role: Principal Investigator
         (Hsu/Makhoul/Allen)Apr 1, 2021 - Mar 31, 2022
    Winthrop P. Rockefeller Team Science Pilot Award
    Feasibility study to improve the assessment of cancer treatment-related cognitive impairment.
    Role: Principal Investigator
    P20GM109005     (BOERMA, MARJAN)Aug 17, 2020 - May 31, 2025
    NIH/Nat. Inst. of General Medical Sciences
    Center for Studies on Host Response to Cancer Therapy
    Role Description: The goal of the study is to examine whether type of cigarette smoked contribute to racial disparity in prostate cancer.
    Role: Principal Investigator
    U01DD001285     (NEMBHARD, WENDY N)Dec 1, 2018 - Aug 31, 2023
    NIH
    RFA-DD-18-001 Birth Defects Study To Evaluate Pregnancy exposures (BD-STEPS) II Core & Component B Steps -Stillbirth
    Role: Co-Investigator
    1U01DD001229-01     Sep 1, 2018 - Aug 7, 2023
    Center for Disease Control and Prevention
    Component A: Arkansas Proposal to participate in the Birth Defect Study to Evaluate Pregnancy exposureS (BD-STEPS II)
    Role: Co-Investigator
    CPPS Pilot Award 2017     (QUICK, CHARLES M)Jul 1, 2017 - Dec 31, 2018
    UAMS College of Medicine
    Cancer Prevention and Population Sciences Program
    Role: Principal Investigator
    CPPSPilotAward2017     (QUICK, CHARLES M)Jul 1, 2017 - Dec 31, 2018
    UAMS College of Medicine
    Cancer Prevention and Population Sciences Program
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Hsu PC, Lan RS, Brasky TM, Marian C, Cheema AK, Ressom HW, Loffredo CA, Pickworth WB, Shields PG. Menthol Smokers: Metabolomic Profiling and Smoking Behavior. Cancer Epidemiol Biomarkers Prev. 2017 01; 26(1):51-60. PMID: 27628308.
      View in: PubMed
    2. Hsu PC, Lan RS, Brasky TM, Marian C, Cheema AK, Ressom HW, Loffredo CA, Pickworth WB, Shields PG. Metabolomic profiles of current cigarette smokers. Mol Carcinog. 2017 02; 56(2):594-606. PMID: 27341184.
      View in: PubMed
    3. Weng DY, Chen J, Taslim C, Hsu PC, Marian C, David SP, Loffredo CA, Shields PG. Persistent alterations of gene expression profiling of human peripheral blood mononuclear cells from smokers. Mol Carcinog. 2016 10; 55(10):1424-37. PMID: 26294040.
      View in: PubMed
    4. Hsu PC, Zhou B, Zhao Y, Ressom HW, Cheema AK, Pickworth W, Shields PG. Feasibility of identifying the tobacco-related global metabolome in blood by UPLC-QTOF-MS. J Proteome Res. 2013 Feb 01; 12(2):679-91. PMID: 23240883.
      View in: PubMed
    5. Hung CH, Li CY, Lai YS, Hsu PC, Hua YM, Yang KD. Discrepant clinical responses and blood chemokine profiles between two non-steroidal anti-inflammatory medications for children with mild persistent asthma. Pediatr Allergy Immunol. 2005 Jun; 16(4):306-9. PMID: 15943593.
      View in: PubMed
    6. Tsai CS, Hsu PC, Huang GS, Lin TC, Hong GJ, Shih CM, Li CY. Midazolam attenuates adenosine diphosphate-induced P-selectin expression and platelet-leucocyte aggregation. Eur J Anaesthesiol. 2004 Nov; 21(11):871-6. PMID: 15717703.
      View in: PubMed
    7. Huang GS, Li CY, Hsu PC, Tsai CS, Lin TC, Wong CS. Sevoflurane anesthesia attenuates adenosine diphosphate-induced P-selectin expression and platelet-leukocyte conjugate formation. Anesth Analg. 2004 Oct; 99(4):1121-1126. PMID: 15385361.
      View in: PubMed
    8. Li CY, Tsai CS, Hsu PC, Chueh SH, Wong CS, Ho ST. Lidocaine attenuates monocyte chemoattractant protein-1 production and chemotaxis in human monocytes: possible mechanisms for its effect on inflammation. Anesth Analg. 2003 Nov; 97(5):1312-1316. PMID: 14570645.
      View in: PubMed
    9. Li CY, Tsai CS, Hsu PC, Wu CT, Wong CS, Ho ST. Dobutamine modulates lipopolysaccharide-induced macrophage inflammatory protein-1alpha and interleukin-8 production in human monocytes. Anesth Analg. 2003 Jul; 97(1):210-5, table of contents. PMID: 12818968.
      View in: PubMed
    10. Li CY, Tsai CS, Chueh SH, Hsu PC, Wang JY, Wong CS, Ho ST. Dobutamine inhibits monocyte chemoattractant protein-1 production and chemotaxis in human monocytes. Anesth Analg. 2003 Jul; 97(1):205-9, table of contents. PMID: 12818967.
      View in: PubMed
    11. Yeh GC, Chen JC, Tsai HC, Wu HH, Lin CY, Hsu PC, Peng YC. Amphetamine inhibits the N-methyl-D-aspartate receptor-mediated responses by directly interacting with the receptor/channel complex. J Pharmacol Exp Ther. 2002 Mar; 300(3):1008-16. PMID: 11861810.
      View in: PubMed
    12. Chen JY, Hsu PC, Hsu IL, Yeh GC. Sequential up-regulation of the c-fos, c-jun and bax genes in the cortex, striatum and cerebellum induced by a single injection of a low dose of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in C57BL/6 mice. Neurosci Lett. 2001 Nov 13; 314(1-2):49-52. PMID: 11698144.
      View in: PubMed
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