Katie Ryan
Title | Assistant Professor |
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Institution | University of Arkansas for Medical Sciences |
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Department | Biochemistry & Molecular Biology, College of Medicine |
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Address | 325 S. Elm St. Mail Slot # 516 Little Rock AR 72205
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ORCID
.gif) | 0000-0003-0488-5603  |
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vCard | Download vCard |
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Teaching Research Rho family GTPases act as ‘molecular switches’ and are master regulators of many aspects of cellular behavior including regulation of the actin cytoskeleton, gene expression, cell cycle, cell migration, and apoptosis. Many cellular processes regulated by Rho GTPases, are commonly dysregulated in cancer.
Our laboratory focuses on the identification of molecular mechanisms and signaling pathways involved in Rho GTPase signaling. Rho family GTPases act as ‘molecular switches’ and are master regulators of many aspects of cellular behavior including regulation of the actin cytoskeleton, gene expression, cell cycle, cell migration, and apoptosis. Many cellular processes regulated by Rho GTPases, are commonly dysregulated in cancer. My work focuses on the role of Rho GTPases in cell migration and invasion in several in vitro cancer models including lung, breast, and skin cancer. We utilize molecular and cellular biology techniques as well as proteomic approaches to identify novel therapeutic targets of metastasis.
AWD55471 (Ryan, Katie)Sep 1, 2022 - Aug 31, 2024 Arkansas Breast Cancer Research Program Defining how Rnd3, a novel regulator of breast cancer invasion, affects the metastatic potential of breast cancer Role: Principal Investigator |
| AWD00055285 (Ryan, Katie)May 1, 2022 - Apr 30, 2023 Barton Award Spring FY22 Ryan Determining How Driver Mutations Affect the Metastatic Potential of Lung Cancer Using Cell-based Assays and a Proteomic Approach Role: Principal Investigator |
| AWD00055290 (Ryan, Katie)Apr 1, 2022 - Mar 31, 2023 Seeds of Science Pilot Award UAMS Cancer Institute A proteomics approach to determining how driver mutations effect the metastatic potential of lung cancer Role: Principal Investigator |
| P20GM109005 (BOERMA, MARJAN)Aug 17, 2020 - May 31, 2025 NIH/Nat. Inst. of General Medical Sciences Center for Studies on Host Response to Cancer Therapy Role: Co-Investigator |
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Tripette J, Murakami H, Ryan KR, Ohta Y, Miyachi M. The contribution of Nintendo Wii Fit series in the field of health: a systematic review and meta-analysis. PeerJ. 2017; 5:e3600. PMID: 28890847.
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Clarke K, Daubon T, Turan N, Soulet F, Mohd Zahari M, Ryan KR, Durant S, He S, Herbert J, Ankers J, Heath JK, Bjerkvig R, Bicknell R, Hotchin NA, Bikfalvi A, Falciani F. Inference of Low and High-Grade Glioma Gene Regulatory Networks Delineates the Role of Rnd3 in Establishing Multiple Hallmarks of Cancer. PLoS Genet. 2015 Jul; 11(7):e1005325. PMID: 26132659.
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Ryan KR, Lock FE, Heath JK, Hotchin NA. Plakoglobin-dependent regulation of keratinocyte apoptosis by Rnd3. J Cell Sci. 2012 Jul 01; 125(Pt 13):3202-9. PMID: 22454524.
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Lock FE, Ryan KR, Poulter NS, Parsons M, Hotchin NA. Differential regulation of adhesion complex turnover by ROCK1 and ROCK2. PLoS One. 2012; 7(2):e31423. PMID: 22348083.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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Year | Publications |
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2012 | 2 | 2015 | 1 | 2017 | 1 |
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