 Katie Ryan
| Title | Assistant Professor |
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| Institution | University of Arkansas for Medical Sciences |
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| Department | Biochemistry & Molecular Biology, College of Medicine |
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| Address | 325 S. Elm St.
Mail Slot # 516
Little Rock AR 72205
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ORCID
.gif) | 0000-0003-0488-5603  |
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| vCard | Download vCard |
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 Teaching Research Rho family GTPases act as ‘molecular switches’ and are master regulators of many aspects of cellular behavior including regulation of the actin cytoskeleton, gene expression, cell cycle, cell migration, and apoptosis. Many cellular processes regulated by Rho GTPases, are commonly dysregulated in cancer.
Our laboratory focuses on the identification of molecular mechanisms and signaling pathways involved in Rho GTPase signaling. Rho family GTPases act as ‘molecular switches’ and are master regulators of many aspects of cellular behavior including regulation of the actin cytoskeleton, gene expression, cell cycle, cell migration, and apoptosis. Many cellular processes regulated by Rho GTPases, are commonly dysregulated in cancer. My work focuses on the role of Rho GTPases in cell migration and invasion in several in vitro cancer models including lung, breast, and skin cancer. We utilize molecular and cellular biology techniques as well as proteomic approaches to identify novel therapeutic targets of metastasis.
P20GM152281 (MACNICOL, ANGUS)Mar 5, 2024 - Dec 31, 2028 NIH/Nat. Inst. of General Medical Sciences
Center for Molecular Interactions in Cancer (CMIC)
Role: Principal Investigator |
| AWD55471 (Ryan, Katie)Sep 1, 2022 - Aug 31, 2024 Arkansas Breast Cancer Research Program
Defining how Rnd3, a novel regulator of breast cancer invasion, affects the metastatic potential of breast cancer
Role: Principal Investigator |
| AWD00055285 (Ryan, Katie)May 1, 2022 - Apr 30, 2023 Barton Award Spring FY22 Ryan
Determining How Driver Mutations Affect the Metastatic Potential of Lung Cancer Using Cell-based Assays and a Proteomic Approach
Role: Principal Investigator |
| AWD00055290 (Ryan, Katie)Apr 1, 2022 - Mar 31, 2023 Seeds of Science Pilot Award UAMS Cancer Institute
A proteomics approach to determining how driver mutations effect the metastatic potential of lung cancer
Role: Principal Investigator |
| P20GM109005 (BOERMA, MARJAN)Jun 24, 2015 - May 31, 2025 NIH
Center for Studies of Host Response to Cancer Therapy
Role: Co-Investigator |
Bibliographic The links below are provided by the researcher to provide access to external online bibliographies that they keep independently from the Profiles System.
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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Saha D, Ryan KR, Lakkaniga NR, Acharya B, Garcia NG, Smith EL, Frett B. Targeting Rearranged during Transfection in Cancer: A Perspective on Small-Molecule Inhibitors and Their Clinical Development. J Med Chem. 2021 08 26; 64(16):11747-11773. PMID: 34402300.
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Saha D, Ryan KR, Lakkaniga NR, Smith EL, Frett B. Pyrazoloadenine Inhibitors of the RET Lung Cancer Oncoprotein Discovered by a Fragment Optimization Approach. ChemMedChem. 2021 05 18; 16(10):1605-1608. PMID: 33559353.
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Ryan KR, Giles F, Morgan GJ. Targeting both BET and CBP/EP300 proteins with the novel dual inhibitors NEO2734 and NEO1132 leads to anti-tumor activity in multiple myeloma. Eur J Haematol. 2021 Jan; 106(1):90-99. PMID: 32997383.
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Schinke C, Boyle EM, Ashby C, Wang Y, Lyzogubov V, Wardell C, Qu P, Hoering A, Deshpande S, Ryan K, Thanendrarajan S, Mohan M, Yarlagadda N, Khan M, Choudhury SR, Zangari M, van Rhee F, Davies F, Barlogie B, Morgan G, Walker BA. Genomic analysis of primary plasma cell leukemia reveals complex structural alterations and high-risk mutational patterns. Blood Cancer J. 2020 06 19; 10(6):70. PMID: 32555163.
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Mikulasova A, Ashby C, Tytarenko RG, Qu P, Rosenthal A, Dent JA, Ryan KR, Bauer MA, Wardell CP, Hoering A, Mavrommatis K, Trotter M, Deshpande S, Yaccoby S, Tian E, Keats J, Auclair D, Jackson GH, Davies FE, Thakurta A, Morgan GJ, Walker BA. Microhomology-mediated end joining drives complex rearrangements and overexpression of MYC and PVT1 in multiple myeloma. Haematologica. 2020 04; 105(4):1055-1066. PMID: 31221783.
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Tripette J, Murakami H, Ryan KR, Ohta Y, Miyachi M. The contribution of Nintendo Wii Fit series in the field of health: a systematic review and meta-analysis. PeerJ. 2017; 5:e3600. PMID: 28890847.
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Clarke K, Daubon T, Turan N, Soulet F, Mohd Zahari M, Ryan KR, Durant S, He S, Herbert J, Ankers J, Heath JK, Bjerkvig R, Bicknell R, Hotchin NA, Bikfalvi A, Falciani F. Inference of Low and High-Grade Glioma Gene Regulatory Networks Delineates the Role of Rnd3 in Establishing Multiple Hallmarks of Cancer. PLoS Genet. 2015 Jul; 11(7):e1005325. PMID: 26132659.
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Ryan KR, Lock FE, Heath JK, Hotchin NA. Plakoglobin-dependent regulation of keratinocyte apoptosis by Rnd3. J Cell Sci. 2012 Jul 01; 125(Pt 13):3202-9. PMID: 22454524.
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Lock FE, Ryan KR, Poulter NS, Parsons M, Hotchin NA. Differential regulation of adhesion complex turnover by ROCK1 and ROCK2. PLoS One. 2012; 7(2):e31423. PMID: 22348083.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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| Year | Publications |
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| 2012 | 2 | | 2015 | 1 | | 2017 | 1 | | 2019 | 1 | | 2020 | 2 | | 2021 | 2 |
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