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Nishank Jain

TitleAssistant Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentInternal Med, College of Medicine
DivisionInternal Med Nephrology
Address324 UAMS Campus Dr.
Mail Slot # LR 111/D@VA
Little Rock AR 72205
ORCID ORCID Icon0000-0001-6356-6579 Additional info
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    Collapse Biography 
    Collapse awards and honors
    2013Fellow of American Society of Nephrology
    2019Fellow of American Heart Association
    2019Red Sash Award for teaching medical students, UAMS

    Collapse Research 
    Collapse research activities and funding
    Hornick Endowment grant     (Nishank Jain)Jan 1, 2021 - Dec 30, 2021
    UAMS Office of Research
    Study of uremic toxins and levels of antiplatelet therapy to investigate mechanisms of excessive stroke in patients with chronic kidney disease
    Role Description: This grant acts as a supplement to the ongoing CKD-Platelet trial. We are measuring levels of antiplatelet drugs and uremic toxins using mass spectrometry; and, compare them between the CKD and the non-CKD groups. My goal is to investigate mechanisms of higher stroke rates in CKD patients vs. non-CKD controls despite receiving antiplatelet therapy.
    Role: Principal Investigator

    Data Scholar Award     (Nishank Jain)Jul 1, 2020 - Jun 30, 2021
    Translational Research Institute, UAMS
    Role Description: This is an observational study of patients on chronic dialysis that are prescribed antiplatelet agents, specifically P2Y12 inhibitors. It used national registry of Medicare patients on chronic dialysis and investigated predictors of bleeding in this patient population who are prescribed antiplatelet drugs. We also explored predictors of recurrent bleeding events in subgroup analyses. As part of the program, I enrolled in a certificate course of healthcare analytics to utilize learned knowledge from the coursework in analyzing databases; hence, generate results related to antiplatelet drugs in CKD patient population. My personal goal is to generate enough knowledge that a multicenter human trial can be designed in an attempt to determine efficacy and safety of antiplatelet drugs in this vulnerable population- precisely those that are excluded systematically from landmark randomized clinical trials.
    Role: Principal Investigator

    Joseph V Bonventre Career Development grant     (Nishank Jain)Jul 1, 2018 - Jun 30, 2021
    American Society of Nephrology Foundation for Kidney Research
    A Mechanistic Study in Patients with Non-Dialysis Chronic Kidney Disease to Investigate Altered Platelet Response to Antiplatelet Therapy (CKD-Platelet Study)
    Role Description: This is a randomized, double blind, placebo controlled clinical trial designed to investigate whether ticagrelor has greater antiplatelet effects than clopidogrel in non-dialysis CKD and inhibits platelets as effectively as in non-CKD controls. We also want to explore the mechanisms underlying the poor response of CKD patients to oral P2Y12 inhibitors.
    Role: Principal Investigator

    16SDG31000045     (JAIN, NISHANK)Jul 1, 2016 - Oct 23, 2019
    American Heart Association
    Effectiveness and safety of clopidogrel, prasugrel and ticagrelor in patients with end stage renal disease (ESCALATE)
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Jain N, Corken A, Kumar A, Davis C, Ware J, Arthur J. Role of Platelets in Chronic Kidney Disease. J Am Soc Nephrol. 2021 Jun 17. PMID: 34140394.
      View in: PubMed
    2. Shapiro A, Chaudhury A, Wang M, Escobar M, Tsao E, Barnowski C, Feng J, Jain N, Quon DV. Real-world data demonstrate improved bleed control and extended dosing intervals for patients with haemophilia B after switching to recombinant factor IX Fc fusion protein (rFIXFc) for up to 5 years. Haemophilia. 2020 Nov; 26(6):975-983. PMID: 33012060.
      View in: PubMed
    3. Su J, Bylsma LC, Jiang X, Morales Arias J, Jain N, Nordyke RJ. Healthcare resource utilization among commercially insured patients with cold agglutinin disease in the United States. J Med Econ. 2020 Aug; 23(8):902-907. PMID: 32362156.
      View in: PubMed
    4. Jain N, Wan F, Kothari M, Adelodun A, Ware J, Sarode R, Hedayati SS. Association of platelet function with depression and its treatment with sertraline in patients with chronic kidney disease: analysis of a randomized trial. BMC Nephrol. 2019 10 29; 20(1):395. PMID: 31664940.
      View in: PubMed
    5. Jain N, Hunt SL, Cui H, Phadnis MA, Mahnken JD, Shireman TI, Dai J, Mehta JL, Rasu RS. Trends for and Clinical Factors Associated with Choice of Oral P2Y12 Inhibitors for Patients on Chronic Dialysis. Cardiovasc Drugs Ther. 2019 10; 33(5):511-521. PMID: 31729588.
      View in: PubMed
    6. Reilly RF, Jain N. Warfarin in nonvalvular atrial fibrillation-Time for a change? Semin Dial. 2019 11; 32(6):520-526. PMID: 31209952.
      View in: PubMed
    7. Gregg LP, Jain N, Carmody T, Minhajuddin AT, Rush AJ, Trivedi MH, Hedayati SS. Fatigue in Nondialysis Chronic Kidney Disease: Correlates and Association with Kidney Outcomes. Am J Nephrol. 2019; 50(1):37-47. PMID: 31167183.
      View in: PubMed
    8. Jain N, Reilly RF. Clinical Pharmacology of Oral Anticoagulants in Patients with Kidney Disease. Clin J Am Soc Nephrol. 2019 02 07; 14(2):278-287. PMID: 29802125.
      View in: PubMed
    9. Singh M, Raghavan D, Williams JS, Martin BC, Hudson TJ, Owen RR, Jain N. Prevalence of Chronic Kidney Disease, Thrombotic Cardiovascular Events, and Use of Oral P2Y12 Inhibitors among Veterans. Am J Nephrol. 2018; 47(2):67-71. PMID: 29393120.
      View in: PubMed
    10. Hedayati SS, Gregg LP, Carmody T, Jain N, Toups M, Rush AJ, Toto RD, Trivedi MH. Effect of Sertraline on Depressive Symptoms in Patients With Chronic Kidney Disease Without Dialysis Dependence: The CAST Randomized Clinical Trial. JAMA. 2017 11 21; 318(19):1876-1890. PMID: 29101402.
      View in: PubMed
    11. Gregg LP, Adams-Huet B, Li X, Colbert G, Jain N, de Lemos JA, Hedayati SS. Effect Modification of Chronic Kidney Disease on the Association of Circulating and Imaging Cardiac Biomarkers With Outcomes. J Am Heart Assoc. 2017 Jul 05; 6(7). PMID: 28679558.
      View in: PubMed
    12. Jain N, Reilly RF. Hungry bone syndrome. Curr Opin Nephrol Hypertens. 2017 07; 26(4):250-255. PMID: 28375869.
      View in: PubMed
    13. Jain N, Carmody T, Minhajuddin AT, Toups M, Trivedi MH, Rush AJ, Hedayati SS. Prognostic Utility of a Self-Reported Depression Questionnaire versus Clinician-Based Assessment on Renal Outcomes. Am J Nephrol. 2016; 44(3):234-44. PMID: 27592294.
      View in: PubMed
    14. Jain N, Reilly RF. Oral P2Y12 Receptor Inhibitors in Hemodialysis Patients Undergoing Percutaneous Coronary Interventions: Current Knowledge and Future Directions. Semin Dial. 2016 09; 29(5):374-81. PMID: 27061079.
      View in: PubMed
    15. Jain N, Li X, Adams-Huet B, Sarode R, Toto RD, Banerjee S, Hedayati SS. Differences in Whole Blood Platelet Aggregation at Baseline and in Response to Aspirin and Aspirin Plus Clopidogrel in Patients With Versus Without Chronic Kidney Disease. Am J Cardiol. 2016 Feb 15; 117(4):656-663. PMID: 26725101.
      View in: PubMed
    16. Colbert G, Jain N, de Lemos JA, Hedayati SS. Utility of traditional circulating and imaging-based cardiac biomarkers in patients with predialysis CKD. Clin J Am Soc Nephrol. 2015 Mar 06; 10(3):515-29. PMID: 25403922.
      View in: PubMed
    17. Jain N, Reilly RF. Effects of dietary interventions on incidence and progression of CKD. Nat Rev Nephrol. 2014 Dec; 10(12):712-24. PMID: 25331786.
      View in: PubMed
    18. Jain N, Reilly RF. Are calcium-based phosphate binders ever preferable in dialysis patients? Semin Dial. 2014 May-Jun; 27(3):269-72. PMID: 24620781.
      View in: PubMed
    19. Jain N, Minhajuddin AT, Neeland IJ, Elsayed EF, Vega GL, Hedayati SS. Association of urinary sodium-to-potassium ratio with obesity in a multiethnic cohort. Am J Clin Nutr. 2014 May; 99(5):992-8. PMID: 24552753.
      View in: PubMed
    20. Jain N, Trivedi MH, Rush AJ, Carmody T, Kurian B, Toto RD, Sarode R, Hedayati SS. Rationale and design of the Chronic Kidney Disease Antidepressant Sertraline Trial (CAST). Contemp Clin Trials. 2013 Jan; 34(1):136-44. PMID: 23085503.
      View in: PubMed
    21. Jain N, Hedayati SS, Sarode R, Banerjee S, Reilly RF. Antiplatelet therapy in the management of cardiovascular disease in patients with CKD: what is the evidence? Clin J Am Soc Nephrol. 2013 Apr; 8(4):665-74. PMID: 23024160.
      View in: PubMed
    22. Jain N, Reilly RF. Risk factors: filling in the gap. Nat Rev Nephrol. 2012 Oct; 8(10):562-3. PMID: 22890182.
      View in: PubMed
    23. Jain N, Kotla S, Little BB, Weideman RA, Brilakis ES, Reilly RF, Banerjee S. Predictors of hyperkalemia and death in patients with cardiac and renal disease. Am J Cardiol. 2012 May 15; 109(10):1510-3. PMID: 22342847.
      View in: PubMed
    24. Jain N, Hedayati SS. How should clinicians interpret cardiac troponin values in patients with ESRD? Semin Dial. 2011 Jul-Aug; 24(4):398-400. PMID: 21851399.
      View in: PubMed
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