Regiospecific and conformationally restrained analogs of melphalan and DL-2-NAM-7 and their affinities for the large neutral amino acid transporter (system LAT1) of the blood-brain barrier.

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Regiospecific and conformationally restrained analogs of melphalan and DL-2-NAM-7 and their affinities for the large neutral amino acid transporter (system LAT1) of the blood-brain barrier.

Matharu J, Oki J, Worthen DR, Smith QR, Crooks PA. Regiospecific and conformationally restrained analogs of melphalan and DL-2-NAM-7 and their affinities for the large neutral amino acid transporter (system LAT1) of the blood-brain barrier. Bioorg Med Chem Lett. 2010 Jun 15; 20(12):3688-91.

View in: PubMed

subject areas

Animals
Biological Transport
Blood-Brain Barrier
Brain
Large Neutral Amino Acid-Transporter 1
Melphalan
Molecular Conformation
Molecular Structure
Myeloablative Agonists
Norbornanes
Protein Binding
Rats
Structure-Activity Relationship

authors with profiles

Peter Crooks