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Nithin Karakala

TitleAssociate Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentInternal Med, College of Medicine
DivisionInternal Med Nephrology
Address324 UAMS Campus Dr.
Mail Slot # 501
Little Rock AR 72205
ORCID ORCID Icon0000-0001-9766-7968 Additional info
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    Collapse Overview 
    Collapse overview
    Dr. Karakala is an Assistant Professor of Medicine in the Division of Nephrology, Department of Internal Medicine. He received his medical degree from Deccan College of Medical Sciences in India. He completed his internal medicine residency at Greater Baltimore Medical Center in Maryland and his nephrology fellowship training at Medical University of South Carolina. He served as the Chief Nephrology Fellow at MUSC as well. Dr. Karakala was on the faculty at MUSC for two years before coming to UAMS. Dr. Karakala is board certified in internal medicine and nephrology. His clinical interests are continuous renal replacement therapy, early prognostic markers of acute kidney injury, and volume management in acute kidney injury. His research interests include biomarkers in renal disease.


    Collapse Research 
    Collapse research activities and funding
    Grant No. IR44 GM 123799-01     (KARAKALA, NITHIN)Apr 23, 2019 - Apr 23, 2020
    Potrero Medical - Pass Through: Biomedical Research Foundation - Arkansas
    Targeting Abdominal Perfusion Pressure in Septic Shock (The MAP APP Study) IRB 228252
    Role: Principal Investigator
    R44GM123799     (KARAKALA, NITHIN)Jan 1, 2019 - Dec 31, 2023
    Potrero Medical - Pass Through: Biomedical Research Foundation - Arkansas
    No FP attached
    Role: Principal Investigator
    Clinical Scientist Award-FY19     (KARAKALA, NITHIN)Jul 1, 2016 - Jun 30, 2019
    UAMS
    Clinical Scientist Award
    Role: Principal Investigator
    ClinicalScientistAward-FY19     (KARAKALA, NITHIN)Jul 1, 2016 - Jun 30, 2019
    UAMS
    Clinical Scientist Award
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Holthoff JH, Karakala N, Basnakian AG, Edmondson RD, Fite TW, Gokden N, Harville Y, Herzog C, Holthoff KG, Juncos LA, Reynolds KL, Shelton RS, Arthur JM. The role of IGFBP-1 in the clinical prognosis and pathophysiology of acute kidney injury. Am J Physiol Renal Physiol. 2025 May 01; 328(5):F647-F661. PMID: 40172487.
      View in: PubMed
    2. Elkalashy A, Rainwater RR, Ali U, Elbahnasawy E, Singh M, Karakala N. Gastrointestinal mucosal cell injury caused by sevelamer crystals- Case series and literature review. J Ren Nutr. 2025 Feb 05. PMID: 39920980.
      View in: PubMed
    3. Holthoff JH, Alge JL, Arthur JM, Ayub F, Bin Homam W, Janech MG, Ravula S, Karakala N. Urinary Complement C3 and Vitamin D-Binding Protein Predict Adverse Outcomes in Patients with Acute Kidney Injury after Cardiac Surgery. Nephron. 2025; 149(2):66-76. PMID: 39348806.
      View in: PubMed
    4. Holthoff JH, Harville Y, Herzog C, Juncos LA, Karakala N, Arthur JM. SOD1 is a novel prognostic biomarker of acute kidney injury following cardiothoracic surgery. BMC Nephrol. 2023 10 11; 24(1):299. PMID: 37821813.
      View in: PubMed
    5. Karakala N, Juncos LA. High-Cutoff Hemodialysis Therapy for Patients with Light Chain Cast Nephropathy and AKI Requiring Dialysis: CON. Kidney360. 2023 08 01; 4(8):1024-1026. PMID: 37212742.
      View in: PubMed
    6. Velez JCQ, Karakala N, Tayebi K, Wickman TJ, Mohamed MMB, Kovacic RA, Therapondos G, Kanduri SR, Allegretti AS, Belcher JM, Regner KR, Wentowski C. Responsiveness to Vasoconstrictor Therapy in Hepatorenal Syndrome Type 1. Kidney360. 2023 04 01; 4(4):e448-e456. PMID: 36763632.
      View in: PubMed
    7. Belcher JM, Parada XV, Simonetto DA, Juncos LA, Karakala N, Wadei HM, Sharma P, Regner KR, Nadim MK, Garcia-Tsao G, Velez JCQ, Parikh SM, Chung RT, Allegretti AS. Terlipressin and the Treatment of Hepatorenal Syndrome: How the CONFIRM Trial Moves the Story Forward. Am J Kidney Dis. 2022 05; 79(5):737-745. PMID: 34606933.
      View in: PubMed
    8. Allegretti AS, Parada XV, Endres P, Zhao S, Krinsky S, St Hillien SA, Kalim S, Nigwekar SU, Flood JG, Nixon A, Simonetto DA, Juncos LA, Karakala N, Wadei HM, Regner KR, Belcher JM, Nadim MK, Garcia-Tsao G, Velez JCQ, Parikh SM, Chung RT. Urinary NGAL as a Diagnostic and Prognostic Marker for Acute Kidney Injury in Cirrhosis: A Prospective Study. Clin Transl Gastroenterol. 2021 05 11; 12(5):e00359. PMID: 33979307.
      View in: PubMed
    9. Juncos LA, Chandrashekar K, Karakala N, Baldwin I. Vascular access, membranes and circuit for CRRT. Semin Dial. 2021 11; 34(6):406-415. PMID: 33939859.
      View in: PubMed
    10. Karakala N, C?rdoba D, Chandrashekar K, Lopez-Ruiz A, Juncos LA. Point-of-Care Ultrasound in Acute Care Nephrology. Adv Chronic Kidney Dis. 2021 01; 28(1):83-90. PMID: 34389140.
      View in: PubMed
    11. Mandalapu R, Kennedy W, Ram R, Jeffus S, Karakala N, Singh M. Peritoneal Dialysis Catheter-Fallopian Tube Fistula. Kidney Int Rep. 2020 Aug; 5(8):1356-1359. PMID: 32775840.
      View in: PubMed
    12. Karakala N, Juncos LA. Providing Continuous Renal Replacement Therapy in Patients on Extracorporeal Membrane Oxygenation. Clin J Am Soc Nephrol. 2020 05 07; 15(5):704-706. PMID: 32086283.
      View in: PubMed
    13. Velez JCQ, Petkovich B, Karakala N, Huggins JT. Point-of-Care Echocardiography Unveils Misclassification of Acute Kidney Injury as Hepatorenal Syndrome. Am J Nephrol. 2019; 50(3):204-211. PMID: 31394538.
      View in: PubMed
    14. Arthur JM, Karakala N, Edmondson RD. Proteomic Analysis for Identification of Biomarkers that Predict Severe Acute Kidney Injury. Nephron. 2018; 140(2):129-133. PMID: 29990988.
      View in: PubMed
    15. Karakala N, Tolwani AJ. Timing of Renal Replacement Therapy for Acute Kidney Injury. J Intensive Care Med. 2019 Feb; 34(2):94-103. PMID: 29739260.
      View in: PubMed
    16. Velez JCQ, Obadan NO, Kaushal A, Alzubaidi M, Bhasin B, Sachdev SH, Karakala N, Arthur JM, Nesbit RM, Phadke GM. Vancomycin-Associated Acute Kidney Injury with a Steep Rise in Serum Creatinine. Nephron. 2018; 139(2):131-142. PMID: 29705806.
      View in: PubMed
    17. Sharma SG, Arthur JM, Bonsib SM, Phelan KD, Singh M, Karakala N, Bulloch KW, Niyyar VD, Velez JCQ. An integrated pathology and ultrasonography-based simulation for training in performing kidney biopsy?. Clin Nephrol. 2018 03; 89(3):214-221. PMID: 29249232.
      View in: PubMed
    18. Singh M, Karakala N, Shah SV. Long-term Adverse Events Associated With Acute Kidney Injury. J Ren Nutr. 2017 11; 27(6):462-464. PMID: 29056166.
      View in: PubMed
    19. Connor MJ, Karakala N. Continuous Renal Replacement Therapy: Reviewing Current Best Practice to Provide High-Quality Extracorporeal Therapy to Critically Ill Patients. Adv Chronic Kidney Dis. 2017 07; 24(4):213-218. PMID: 28778360.
      View in: PubMed
    20. Heincelman M, Karakala N, Rockey DC. Acute Lymphoblastic Leukemia in a Young Adult Presenting as Hepatitis and Acute Kidney Injury. J Investig Med High Impact Case Rep. 2016 Jul-Sep; 4(3):2324709616665866. PMID: 27722178.
      View in: PubMed
    21. Karakala N, Tolwani A. We Use Heparin as the Anticoagulant for CRRT. Semin Dial. 2016 07; 29(4):272-4. PMID: 27082940.
      View in: PubMed
    22. Velez JC, Kadian M, Taburyanskaya M, Bohm NM, Delay TA, Karakala N, Rockey DC, Nietert PJ, Goodwin AJ, Whelan TP. Hepatorenal Acute Kidney Injury and the Importance of Raising Mean Arterial Pressure. Nephron. 2015; 131(3):191-201. PMID: 26485256.
      View in: PubMed
    23. Huggins JT, Karakala N, Campbell R, Kummerfeldt C, Nestor J, Pastis NJ, Doelken P. A 37-year-old woman with diabetes mellitus, systemic hypertension, and chronic kidney disease admitted with multifocal pneumonia and empyema. Chest. 2014 Aug; 146(2):e41-e46. PMID: 25091761.
      View in: PubMed
    24. Karakala N, Raghunathan K, Shaw AD. Intravenous fluids in sepsis: what to use and what to avoid. Curr Opin Crit Care. 2013 Dec; 19(6):537-43. PMID: 24240819.
      View in: PubMed
    25. Alge JL, Karakala N, Neely BA, Janech MG, Tumlin JA, Chawla LS, Shaw AD, Arthur JM. Association of elevated urinary concentration of renin-angiotensin system components and severe AKI. Clin J Am Soc Nephrol. 2013 Dec; 8(12):2043-52. PMID: 24009222.
      View in: PubMed
    26. Alge JL, Karakala N, Neely BA, Janech MG, Velez JC, Arthur JM. Urinary angiotensinogen predicts adverse outcomes among acute kidney injury patients in the intensive care unit. Crit Care. 2013 Apr 15; 17(2):R69. PMID: 23587112.
      View in: PubMed
    27. Alge JL, Karakala N, Neely BA, Janech MG, Tumlin JA, Chawla LS, Shaw AD, Arthur JM. Urinary angiotensinogen and risk of severe AKI. Clin J Am Soc Nephrol. 2013 Feb; 8(2):184-93. PMID: 23143504.
      View in: PubMed
    28. Karakala N, Steed LL, Ullian ME. Peritonitis from Mycobacterium wolinskyi in a chronic peritoneal dialysis patient. Int Urol Nephrol. 2013 Feb; 45(1):289-91. PMID: 22127408.
      View in: PubMed
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