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Nithin Karakala

TitleAssociate Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentInternal Med, College of Medicine
DivisionInternal Med Nephrology
Address324 UAMS Campus Dr.
Mail Slot # 501
Little Rock AR 72205
ORCID ORCID Icon0000-0001-9766-7968 Additional info
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    Collapse Overview 
    Collapse overview
    Dr. Karakala is an Assistant Professor of Medicine in the Division of Nephrology, Department of Internal Medicine. He received his medical degree from Deccan College of Medical Sciences in India. He completed his internal medicine residency at Greater Baltimore Medical Center in Maryland and his nephrology fellowship training at Medical University of South Carolina. He served as the Chief Nephrology Fellow at MUSC as well. Dr. Karakala was on the faculty at MUSC for two years before coming to UAMS. Dr. Karakala is board certified in internal medicine and nephrology. His clinical interests are continuous renal replacement therapy, early prognostic markers of acute kidney injury, and volume management in acute kidney injury. His research interests include biomarkers in renal disease.


    Collapse Research 
    Collapse research activities and funding
    Grant No. IR44 GM 123799-01     (KARAKALA, NITHIN)Apr 23, 2019 - Apr 23, 2020
    Potrero Medical - Pass Through: Biomedical Research Foundation - Arkansas
    Targeting Abdominal Perfusion Pressure in Septic Shock (The MAP APP Study) IRB 228252
    Role: Principal Investigator

    R44GM123799     (KARAKALA, NITHIN)Jan 1, 2019 - Dec 31, 2023
    Potrero Medical - Pass Through: Biomedical Research Foundation - Arkansas
    No FP attached
    Role: Principal Investigator

    Clinical Scientist Award-FY19     (KARAKALA, NITHIN)Jul 1, 2016 - Jun 30, 2019
    UAMS
    Clinical Scientist Award
    Role: Principal Investigator

    ClinicalScientistAward-FY19     (KARAKALA, NITHIN)Jul 1, 2016 - Jun 30, 2019
    UAMS
    Clinical Scientist Award
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Holthoff JH, Karakala N, Basnakian AG, Edmondson RD, Fite TW, Gokden N, Harville Y, Herzog C, Holthoff KG, Juncos LA, Reynolds KL, Shelton RS, Arthur JM. The role of IGFBP-1 in the clinical prognosis and pathophysiology of acute kidney injury. Am J Physiol Renal Physiol. 2025 May 01; 328(5):F647-F661. PMID: 40172487.
      View in: PubMed
    2. Elkalashy A, Rainwater RR, Ali U, Elbahnasawy E, Singh M, Karakala N. Gastrointestinal mucosal cell injury caused by sevelamer crystals- Case series and literature review. J Ren Nutr. 2025 Feb 05. PMID: 39920980.
      View in: PubMed
    3. Karakala N, Juncos LA. High-Cutoff Hemodialysis Therapy for Patients with Light Chain Cast Nephropathy and AKI Requiring Dialysis: CON. Kidney360. 2023 08 01; 4(8):1024-1026. PMID: 37212742.
      View in: PubMed
    4. Velez JCQ, Karakala N, Tayebi K, Wickman TJ, Mohamed MMB, Kovacic RA, Therapondos G, Kanduri SR, Allegretti AS, Belcher JM, Regner KR, Wentowski C. Responsiveness to Vasoconstrictor Therapy in Hepatorenal Syndrome Type 1. Kidney360. 2023 04 01; 4(4):e448-e456. PMID: 36763632.
      View in: PubMed
    5. Allegretti AS, Parada XV, Endres P, Zhao S, Krinsky S, St Hillien SA, Kalim S, Nigwekar SU, Flood JG, Nixon A, Simonetto DA, Juncos LA, Karakala N, Wadei HM, Regner KR, Belcher JM, Nadim MK, Garcia-Tsao G, Velez JCQ, Parikh SM, Chung RT. Urinary NGAL as a Diagnostic and Prognostic Marker for Acute Kidney Injury in Cirrhosis: A Prospective Study. Clin Transl Gastroenterol. 2021 05 11; 12(5):e00359. PMID: 33979307.
      View in: PubMed
    6. Mandalapu R, Kennedy W, Ram R, Jeffus S, Karakala N, Singh M. Peritoneal Dialysis Catheter-Fallopian Tube Fistula. Kidney Int Rep. 2020 Aug; 5(8):1356-1359. PMID: 32775840.
      View in: PubMed
    7. Velez JCQ, Petkovich B, Karakala N, Huggins JT. Point-of-Care Echocardiography Unveils Misclassification of Acute Kidney Injury as Hepatorenal Syndrome. Am J Nephrol. 2019; 50(3):204-211. PMID: 31394538.
      View in: PubMed
    8. Karakala N, Tolwani AJ. Timing of Renal Replacement Therapy for Acute Kidney Injury. J Intensive Care Med. 2019 Feb; 34(2):94-103. PMID: 29739260.
      View in: PubMed
    9. Velez JCQ, Obadan NO, Kaushal A, Alzubaidi M, Bhasin B, Sachdev SH, Karakala N, Arthur JM, Nesbit RM, Phadke GM. Vancomycin-Associated Acute Kidney Injury with a Steep Rise in Serum Creatinine. Nephron. 2018; 139(2):131-142. PMID: 29705806.
      View in: PubMed
    10. Sonderman KA, Wolf LL, Armstrong LB, Taylor K, Jiang W, Weil BR, Koehlmoos TP, Ricca RL, Weldon CB, Haider AH, Rice-Townsend SE. Testicular atrophy following inguinal hernia repair in children. Pediatr Surg Int. 2018 May; 34(5):553-560. PMID: 29056166.
      View in: PubMed
    11. Sonderman KA, Wolf LL, Armstrong LB, Taylor K, Jiang W, Weil BR, Koehlmoos TP, Ricca RL, Weldon CB, Haider AH, Rice-Townsend SE. Testicular atrophy following inguinal hernia repair in children. Pediatr Surg Int. 2018 May; 34(5):553-560. PMID: 33939859.
      View in: PubMed
    12. Sonderman KA, Wolf LL, Armstrong LB, Taylor K, Jiang W, Weil BR, Koehlmoos TP, Ricca RL, Weldon CB, Haider AH, Rice-Townsend SE. Testicular atrophy following inguinal hernia repair in children. Pediatr Surg Int. 2018 May; 34(5):553-560. PMID: 34606933.
      View in: PubMed
    13. Sonderman KA, Wolf LL, Armstrong LB, Taylor K, Jiang W, Weil BR, Koehlmoos TP, Ricca RL, Weldon CB, Haider AH, Rice-Townsend SE. Testicular atrophy following inguinal hernia repair in children. Pediatr Surg Int. 2018 May; 34(5):553-560. PMID: 39348806.
      View in: PubMed
    14. Connor MJ, Karakala N. Continuous Renal Replacement Therapy: Reviewing Current Best Practice to Provide High-Quality Extracorporeal Therapy to Critically Ill Patients. Adv Chronic Kidney Dis. 2017 07; 24(4):213-218. PMID: 28778360.
      View in: PubMed
    15. Heincelman M, Karakala N, Rockey DC. Acute Lymphoblastic Leukemia in a Young Adult Presenting as Hepatitis and Acute Kidney Injury. J Investig Med High Impact Case Rep. 2016 Jul-Sep; 4(3):2324709616665866. PMID: 27722178.
      View in: PubMed
    16. Velez JC, Kadian M, Taburyanskaya M, Bohm NM, Delay TA, Karakala N, Rockey DC, Nietert PJ, Goodwin AJ, Whelan TP. Hepatorenal Acute Kidney Injury and the Importance of Raising Mean Arterial Pressure. Nephron. 2015; 131(3):191-201. PMID: 26485256.
      View in: PubMed
    17. Karakala N, Raghunathan K, Shaw AD. Intravenous fluids in sepsis: what to use and what to avoid. Curr Opin Crit Care. 2013 Dec; 19(6):537-43. PMID: 24240819.
      View in: PubMed
    18. Alge JL, Karakala N, Neely BA, Janech MG, Tumlin JA, Chawla LS, Shaw AD, Arthur JM. Association of elevated urinary concentration of renin-angiotensin system components and severe AKI. Clin J Am Soc Nephrol. 2013 Dec; 8(12):2043-52. PMID: 24009222.
      View in: PubMed
    19. Alge JL, Karakala N, Neely BA, Janech MG, Velez JC, Arthur JM. Urinary angiotensinogen predicts adverse outcomes among acute kidney injury patients in the intensive care unit. Crit Care. 2013 Apr 15; 17(2):R69. PMID: 23587112.
      View in: PubMed
    20. McGoogan KE, Haafiz AB, Gonz?lez Peralta RP. Herpes simplex virus hepatitis in infants: clinical outcomes and correlates of disease severity. J Pediatr. 2011 Oct; 159(4):608-11. PMID: 25091761.
      View in: PubMed
    21. McGoogan KE, Haafiz AB, Gonz?lez Peralta RP. Herpes simplex virus hepatitis in infants: clinical outcomes and correlates of disease severity. J Pediatr. 2011 Oct; 159(4):608-11. PMID: 23143504.
      View in: PubMed
    22. McGoogan KE, Haafiz AB, Gonz?lez Peralta RP. Herpes simplex virus hepatitis in infants: clinical outcomes and correlates of disease severity. J Pediatr. 2011 Oct; 159(4):608-11. PMID: 27082940.
      View in: PubMed
    23. McGoogan KE, Haafiz AB, Gonz?lez Peralta RP. Herpes simplex virus hepatitis in infants: clinical outcomes and correlates of disease severity. J Pediatr. 2011 Oct; 159(4):608-11. PMID: 22127408.
      View in: PubMed
    24. McGoogan KE, Haafiz AB, Gonz?lez Peralta RP. Herpes simplex virus hepatitis in infants: clinical outcomes and correlates of disease severity. J Pediatr. 2011 Oct; 159(4):608-11. PMID: 29249232.
      View in: PubMed
    25. McGoogan KE, Haafiz AB, Gonz?lez Peralta RP. Herpes simplex virus hepatitis in infants: clinical outcomes and correlates of disease severity. J Pediatr. 2011 Oct; 159(4):608-11. PMID: 29990988.
      View in: PubMed
    26. McGoogan KE, Haafiz AB, Gonz?lez Peralta RP. Herpes simplex virus hepatitis in infants: clinical outcomes and correlates of disease severity. J Pediatr. 2011 Oct; 159(4):608-11. PMID: 32086283.
      View in: PubMed
    27. McGoogan KE, Haafiz AB, Gonz?lez Peralta RP. Herpes simplex virus hepatitis in infants: clinical outcomes and correlates of disease severity. J Pediatr. 2011 Oct; 159(4):608-11. PMID: 37821813.
      View in: PubMed
    28. McGoogan KE, Haafiz AB, Gonz?lez Peralta RP. Herpes simplex virus hepatitis in infants: clinical outcomes and correlates of disease severity. J Pediatr. 2011 Oct; 159(4):608-11. PMID: 34389140.
      View in: PubMed
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