Peter Crooks
Title | Professor |
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Institution | University of Arkansas for Medical Sciences |
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Department | Pharmaceutical Science, College of Pharmacy |
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Address | 140-2D Biomedical Research II 200 South Cedar Mail Slot # 622 Little Rock AR 72202
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Phone | 501-686-6495 |
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vCard | Download vCard |
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Research 1R01AG084473 (BARGER, STEVEN W)Apr 15, 2023 - Mar 31, 2028 NIH/Nat. Inst. on Aging Role of glucose transport in Alzheimer’s disease pathogenesis Role: Principal Investigator |
| R01AG084473 (BARGER, STEVEN W)Apr 15, 2023 - Mar 31, 2028 NIH Role of glucose transport in Alzheimer's disease pathogenesis Role: Co-Investigator |
| 2031111 (CROOKS, PETER A)Jun 1, 2020 - May 31, 2022 National Science Foundation - Pass Through: University of Arkansas at Fayetteville Covid-19 RAPID: Sprayable Cellulosic nanoparticle Coatings for COVID 19 Anti-viral Applications.
NSF RAPID AWARD 2031111 Role: Principal Investigator |
| R21DA049585 (BRENTS, LISA KAYE)Aug 1, 2019 - Jul 31, 2021 NIH Use of precision deuteration to determine the contribution of norbuprenorphine to buprenorphine-associated neonatal abstinence syndrome Role: Co-Investigator |
| U01DA043908 (CROOKS, PETER A)Aug 1, 2018 - Jul 31, 2019 NIH/Nat. Inst. on Drug Abuse - Pass Through: University of Kentucky Research Foundation Development of Novel Therapeutics for Methamphetamine Abuse - Continuation Role: Principal Investigator |
| W81XWH-15-1-0716 (SMELTZER, MARK S)Sep 30, 2015 - Sep 30, 2019 US Department of Defense Enhancing the prevention and treatment of orthopaedic infections associated with traumatic injury Role: Co-Investigator |
| 16-EPS3-0013 (GRIFFIN, ROBERT J)Sep 18, 2015 - Jul 31, 2021 Arkansas Economic Development Commission - Pass Through: National Science Foundation Functional optical biomarkers of response to therapy in head and neck squamous cell carcinoma- Resubmission Role: Co-Investigator |
| OIA-145788 (GRIFFIN, ROBERT J)Sep 18, 2015 - Jul 31, 2021 National Science Foundation - Pass Through: Arkansas Economic Development Commission RII Track-1: Arkansas ASSET Initiative III - Continuation Y5 - Continuation Role: Co-Investigator |
| P20GM109005 (BOERMA, MARJAN)Jun 24, 2015 - May 31, 2025 NIH Center for Studies of Host Response to Cancer Therapy Role: Co-Investigator |
| U01DA013519 (CROOKS, PETER A)Jul 1, 2014 - Jun 30, 2018 NIH/Nat. Inst. on Drug Abuse - Pass Through: University of Kentucky Research Foundation Development of Novel Therapies for Methamphetamine Abuse Role: Principal Investigator |
| R01CA140409 (CROOKS, PETER A)Dec 1, 2011 - Dec 30, 2014 NIH/Nat. Cancer Institute - Pass Through: Vanderbilt University Development of Small Molecule Radiation Sensitizers Role: Principal Investigator |
| R01CA158275 (CROOKS, PETER ANTHONY)Jul 1, 2011 - May 31, 2017 NIH Novel melampomagnolide B-based prodrugs for the treatment of leukemia Role: Principal Investigator |
| R56DK076735 (DRANOFF, JONATHAN A)Dec 1, 2006 - Aug 31, 2016 NIH Regulation of hepatic stellate cells by intracellular calcium Role: Co-Investigator |
| P01AG012411 (GRIFFIN, SUE TILTON)Jun 1, 1995 - May 31, 2021 NIH Early Events in Alzheimer Pathogenesis Role: Co-Principal Investigator |
Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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Chandler CM, Nickell JR, George Wilson A, Culver JP, Crooks PA, Bardo MT, Dwoskin LP. Vesicular monoamine transporter-2 inhibitor JPC-141 prevents methamphetamine-induced dopamine toxicity and blocks methamphetamine self-administration in rats. Biochem Pharmacol. 2024 Oct; 228:116189. PMID: 38580165.
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Kakraba S, Ayyadevara S, Mainali N, Balasubramaniam M, Bowroju S, Penthala NR, Atluri R, Barger SW, Griffin ST, Crooks PA, Shmookler Reis RJ. Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan. Pharmaceuticals (Basel). 2023 Oct 20; 16(10). PMID: 37895969.
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Hestekin CN, Pakkaner E, Hestekin JA, De Souza LS, Chowdhury PP, Mar?al JL, Moore J, Hesse SA, Takacs CJ, Tassone CJ, Dachavaram SS, Crooks PA, Williams K, Kurtz I. High flux novel polymeric membrane for renal applications. Sci Rep. 2023 07 20; 13(1):11703. PMID: 37474512.
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Janganati V, Salazar P, Parks BJ, Gorman GS, Prather PL, Peterson EC, Alund AW, Moran JH, Crooks PA, Brents LK. Deuterated buprenorphine retains pharmacodynamic properties of buprenorphine and resists metabolism to the active metabolite norbuprenorphine in rats. Front Pharmacol. 2023; 14:1123261. PMID: 37229250.
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LoBianco FV, Krager KJ, Johnson E, Godwin CO, Allen AR, Crooks PA, Compadre CM, Borrelli MJ, Aykin-Burns N. Parthenolide induces rapid thiol oxidation that leads to ferroptosis in hepatocellular carcinoma cells. Front Toxicol. 2022; 4:936149. PMID: 36591540.
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Lee C, Sinha AK, Henry K, Walbaum AW, Crooks PA, Holt JC. Characterizing the Access of Cholinergic Antagonists to Efferent Synapses in the Inner Ear. Front Neurosci. 2021; 15:754585. PMID: 34970112.
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Darrigues E, Zhao EH, De Loose A, Lee MP, Borrelli MJ, Eoff RL, Galileo DS, Penthala NR, Crooks PA, Rodriguez A. Biobanked Glioblastoma Patient-Derived Organoids as a Precision Medicine Model to Study Inhibition of Invasion. Int J Mol Sci. 2021 Oct 03; 22(19). PMID: 34639060.
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Bowroju SK, Penthala NR, Lakkaniga NR, Balasubramaniam M, Ayyadevara S, Shmookler Reis RJ, Crooks PA. Novel hydroxybenzylamine-deoxyvasicinone hybrids as anticholinesterase therapeutics for Alzheimer's disease. Bioorg Med Chem. 2021 09 01; 45:116311. PMID: 34304133.
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Penthala NR, Balasubramaniam M, Dachavaram SS, Morris EJ, Bhat-Nakshatri P, Ponder J, Jordan CT, Nakshatri H, Crooks PA. Antitumor properties of novel sesquiterpene lactone analogs as NF?B inhibitors that bind to the IKK? ubiquitin-like domain (ULD). Eur J Med Chem. 2021 Nov 15; 224:113675. PMID: 34229108.
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Adeneye AA, Olorundare OE, Omobowale TO, Akinsola AO, Kolo PM, Albrecht RMA, Crooks PA. Selected Antihypertensive Agents and Their Fixed-Dose Combinations Effectively Ameliorate Trastuzumab-Mediated Cardiac Dysfunction In Rats. Niger J Physiol Sci. 2021 Jun 30; 36(1):57-65. PMID: 34987247.
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Olorundare OE, Adeneye AA, Akinsola AO, Ajayi AM, Agede OA, Soyemi SS, Mgbehoma AI, Okoye II, Albrecht RM, Ntambi JM, Crooks PA. Therapeutic Potentials of Selected Antihypertensive Agents and Their Fixed-Dose Combinations Against Trastuzumab-Mediated Cardiotoxicity. Front Pharmacol. 2020; 11:610331. PMID: 33897413.
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Albayati ZAF, Penthala NR, Bommagani S, Post GR, Smeltzer MS, Crooks PA. Evaluation of bone and kidney toxicity of BT2-peg2, a potential carrier for the targeted delivery of antibiotics to bone. Toxicol Rep. 2021; 8:359-364. PMID: 33665133.
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Yadlapalli JSK, Albayati ZAF, Breen PJ, Dobretsov M, Penthala NR, Hendrickson HP, Crooks PA. A pharmacokinetic study of morphine-6-O-sulfate in rat plasma and brain. Drug Dev Res. 2021 09; 82(6):802-814. PMID: 33427316.
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Traver G, Sekhar KR, Crooks PA, Keeney DS, Freeman ML. Targeting NPM1 in irradiated cells inhibits NPM1 binding to RAD51, RAD51 foci formation and radiosensitizes NSCLC. Cancer Lett. 2021 03 01; 500:220-227. PMID: 33358698.
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Balasubramaniam M, Mainali N, Bowroju SK, Atluri P, Penthala NR, Ayyadevera S, Crooks PA, Shmookler Reis RJ. Structural modeling of GSK3? implicates the inactive (DFG-out) conformation as the target bound by TDZD analogs. Sci Rep. 2020 10 27; 10(1):18326. PMID: 33110096.
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Yang JF, Williams AH, Penthala NR, Prather PL, Crooks PA, Zhan CG. Binding Modes and Selectivity of Cannabinoid 1 (CB1) and Cannabinoid 2 (CB2) Receptor Ligands. ACS Chem Neurosci. 2020 10 21; 11(20):3455-3463. PMID: 32997485.
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Penthala NR, Shoeib A, Dachavaram SS, Cabanlong CV, Yang J, Zhan CG, Prather PL, Crooks PA. 7-Azaindolequinuclidinones (7-AIQD): A novel class of cannabinoid 1 (CB1) and cannabinoid 2 (CB2) receptor ligands. Bioorg Med Chem Lett. 2020 11 15; 30(22):127501. PMID: 32882418.
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Bowroju SK, Mainali N, Ayyadevara S, Penthala NR, Krishnamachari S, Kakraba S, Shmookler Reis RJ, Crooks PA. Design and Synthesis of Novel Hybrid 8-Hydroxy Quinoline-Indole Derivatives as Inhibitors of A? Self-Aggregation and Metal Chelation-Induced A? Aggregation. Molecules. 2020 08 08; 25(16). PMID: 32784464.
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Wang R, Kumar B, Bhat-Nakshatri P, Prasad MS, Jacobsen MH, Ovalle G, Maguire C, Sandusky G, Trivedi T, Mohammad KS, Guise T, Penthala NR, Crooks PA, Liu J, Zimmers T, Nakshatri H. Aging-associated skeletal muscle defects in HER2/Neu transgenic mammary tumor model. JCSM Rapid Commun. 2021 Jan-Jun; 4(1):24-39. PMID: 33842876.
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Moore JP, Robling K, Romero C, Kiper K, Dachavaram SS, Crooks PA, Hestekin JA. Oxone?-Mediated TEMPO-Oxidized Cellulose Nanomaterial Ultrafiltration and Dialysis Mixed-Matrix Hollow Fiber Membranes. Polymers (Basel). 2020 Jun 15; 12(6). PMID: 32549325.
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Moore Ii JP, Dachavaram SS, Bommagani S, Penthala NR, Venkatraman P, Foster EJ, Crooks PA, A Hestekin J. Oxone?-Mediated TEMPO-Oxidized Cellulose Nanomaterials form I and form II. Molecules. 2020 Apr 17; 25(8). PMID: 32316421.
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Liu X, Gao Z, Fu Q, Song L, Zhang P, Zhang X, Hendrickson H, Crooks PA, Zhou D, Zheng G. Deuteration of the farnesyl terminal methyl groups of d-tocotrienol and its effects on the metabolic stability and ability of inducing G-CSF production. Bioorg Med Chem. 2020 06 01; 28(11):115498. PMID: 32291146.
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Kakraba S, Ayyadevara S, Penthala NR, Balasubramaniam M, Ganne A, Liu L, Alla R, Bommagani SB, Barger SW, Griffin WST, Crooks PA, Shmookler Reis RJ. A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer's Disease. Front Mol Neurosci. 2019; 12:310. PMID: 31920540.
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Balasubramaniam M, Ayyadevara S, Ganne A, Kakraba S, Penthala NR, Du X, Crooks PA, Griffin ST, Shmookler Reis RJ. Aggregate Interactome Based on Protein Cross-linking Interfaces Predicts Drug Targets to Limit Aggregation in Neurodegenerative Diseases. iScience. 2019 Oct 25; 20:248-264. PMID: 31593839.
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Lee NR, Zheng G, Leggas M, Janganati V, Nickell JR, Crooks PA, Bardo MT, Dwoskin LP. GZ-11608, a Vesicular Monoamine Transporter-2 Inhibitor, Decreases the Neurochemical and Behavioral Effects of Methamphetamine. J Pharmacol Exp Ther. 2019 11; 371(2):526-543. PMID: 31413138.
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Ketkar A, Maddukuri L, Penthala NR, Reed MR, Zafar MK, Crooks PA, Eoff RL. Inhibition of Human DNA Polymerases Eta and Kappa by Indole-Derived Molecules Occurs through Distinct Mechanisms. ACS Chem Biol. 2019 06 21; 14(6):1337-1351. PMID: 31082191.
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Ford BM, Cabanlong CV, Tai S, Franks LN, Penthala NR, Crooks PA, Prather PL, Fantegrossi WE. Reduced Tolerance and Asymmetrical Crosstolerance to Effects of the Indole Quinuclidinone Analog PNR-4-20, a G Protein-Biased Cannabinoid 1 Receptor Agonist in Mice: Comparisons with ?9-Tetrahydrocannabinol and JWH-018. J Pharmacol Exp Ther. 2019 05; 369(2):259-269. PMID: 30833484.
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Marecki JC, Aarattuthodiyil S, Byrd AK, Penthala NR, Crooks PA, Raney KD. N-Naphthoyl-substituted indole thio-barbituric acid analogs inhibit the helicase activity of the hepatitis C virus NS3. Bioorg Med Chem Lett. 2019 02 01; 29(3):430-434. PMID: 30578035.
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Kearney SE, Zahor?nszky-Kohalmi G, Brimacombe KR, Henderson MJ, Lynch C, Zhao T, Wan KK, Itkin Z, Dillon C, Shen M, Cheff DM, Lee TD, Bougie D, Cheng K, Coussens NP, Dorjsuren D, Eastman RT, Huang R, Iannotti MJ, Karavadhi S, Klumpp-Thomas C, Roth JS, Sakamuru S, Sun W, Titus SA, Yasgar A, Zhang YQ, Zhao J, Andrade RB, Brown MK, Burns NZ, Cha JK, Mevers EE, Clardy J, Clement JA, Crooks PA, Cuny GD, Ganor J, Moreno J, Morrill LA, Picazo E, Susick RB, Garg NK, Goess BC, Grossman RB, Hughes CC, Johnston JN, Joullie MM, Kinghorn AD, Kingston DGI, Krische MJ, Kwon O, Maimone TJ, Majumdar S, Maloney KN, Mohamed E, Murphy BT, Nagorny P, Olson DE, Overman LE, Brown LE, Snyder JK, Porco JA, Rivas F, Ross SA, Sarpong R, Sharma I, Shaw JT, Xu Z, Shen B, Shi W, Stephenson CRJ, Verano AL, Tan DS, Tang Y, Taylor RE, Thomson RJ, Vosburg DA, Wu J, Wuest WM, Zakarian A, Zhang Y, Ren T, Zuo Z, Inglese J, Michael S, Simeonov A, Zheng W, Shinn P, Jadhav A, Boxer MB, Hall MD, Xia M, Guha R, Rohde JM. Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. ACS Cent Sci. 2018 Dec 26; 4(12):1727-1741. PMID: 30648156.
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Bommagani S, Penthala NR, Balasubramaniam M, Kuravi S, Caldas-Lopes E, Guzman ML, Balusu R, Crooks PA. A novel tetrazole analogue of resveratrol is a potent anticancer agent. Bioorg Med Chem Lett. 2019 01 15; 29(2):172-178. PMID: 30528695.
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Maggio SE, Saunders MA, Nixon K, Prendergast MA, Zheng G, Crooks PA, Dwoskin LP, Bell RL, Bardo MT. An improved model of ethanol and nicotine co-use in female P rats: Effects of naltrexone, varenicline, and the selective nicotinic a6?2* antagonist r-bPiDI. Drug Alcohol Depend. 2018 12 01; 193:154-161. PMID: 30384323.
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Bommagani S, Penthala NR, Parkin S, Crooks PA. Crystal structure of 13-(E)-(2-amino-benzyl-idene)parthenolide. Acta Crystallogr E Crystallogr Commun. 2018 Nov 01; 74(Pt 11):1543-1546. PMID: 30443377.
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Lamture G, Crooks PA, Borrelli MJ. Actinomycin-D and dimethylamino-parthenolide synergism in treating human pancreatic cancer cells. Drug Dev Res. 2018 09; 79(6):287-294. PMID: 30295945.
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Dachavaram SS, Penthala NR, Calahan JL, Munson EJ, Crooks PA. Highly sulphated cellulose: a versatile, reusable and selective desilylating agent for deprotection of alcoholic TBDMS ethers. Org Biomol Chem. 2018 08 22; 16(33):6057-6062. PMID: 30090907.
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Janganati V, Ponder J, Balasubramaniam M, Bhat-Nakshatri P, Bar EE, Nakshatri H, Jordan CT, Crooks PA. MMB triazole analogs are potent NF-?B inhibitors and anti-cancer agents against both hematological and solid tumor cells. Eur J Med Chem. 2018 Sep 05; 157:562-581. PMID: 30121494.
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Flores-Lopez G, Moreno-Lorenzana D, Ayala-Sanchez M, Aviles-Vazquez S, Torres-Martinez H, Crooks PA, Guzman ML, Mayani H, Ch?vez-Gonz?lez A. Parthenolide and DMAPT induce cell death in primitive CML cells through reactive oxygen species. J Cell Mol Med. 2018 10; 22(10):4899-4912. PMID: 30079458.
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Yadlapalli JSK, Bommagani SB, Mahelona RD, Wan A, Gannon BM, Penthala NR, Dobretsov M, Crooks PA, Fantegrossi WE. Evaluation of morphine-like effects of the mixed mu/delta agonist morphine-6-O-sulfate in rats: Drug discrimination and physical dependence. Pharmacol Res Perspect. 2018 07; 6(4):e00403. PMID: 29930811.
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Yadlapalli JSK, Dogra N, Walbaum AW, Prather PL, Crooks PA, Dobretsov M. Pinprick hypo- and hyperalgesia in diabetic rats: Can diet content affect experimental outcome? Neurosci Lett. 2018 04 23; 673:24-27. PMID: 29490230.
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Maggio SE, Saunders MA, Baxter TA, Nixon K, Prendergast MA, Zheng G, Crooks P, Dwoskin LP, Slack RD, Newman AH, Bell RL, Bardo MT. Effects of the nicotinic agonist varenicline, nicotinic antagonist r-bPiDI, and DAT inhibitor (R)-modafinil on co-use of ethanol and nicotine in female P rats. Psychopharmacology (Berl). 2018 05; 235(5):1439-1453. PMID: 29455292.
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Lee NR, Zheng G, Crooks PA, Bardo MT, Dwoskin LP. New Scaffold for Lead Compounds to Treat Methamphetamine Use Disorders. AAPS J. 2018 02 09; 20(2):29. PMID: 29427069.
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Kangiser MM, Dwoskin LP, Zheng G, Crooks PA, Stairs DJ. Varenicline and GZ-793A differentially decrease methamphetamine self-administration under a multiple schedule of reinforcement in rats. Behav Pharmacol. 2018 02; 29(1):87-97. PMID: 28863003.
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Zafar MK, Maddukuri L, Ketkar A, Penthala NR, Reed MR, Eddy S, Crooks PA, Eoff RL. A Small-Molecule Inhibitor of Human DNA Polymerase ? Potentiates the Effects of Cisplatin in Tumor Cells. Biochemistry. 2018 02 20; 57(7):1262-1273. PMID: 29345908.
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Madadi NR, Penthala NR, Ketkar A, Eoff RL, Trujullo-Alonso V, Guzman ML, Crooks PA. Synthesis and Evaluation of 2-Naphthaleno trans-Stilbenes and Cyanostilbenes as Anticancer Agents. Anticancer Agents Med Chem. 2018; 18(4):556-564. PMID: 28403783.
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Yadlapalli JSK, Dogra N, Walbaum AW, Prather PL, Crooks PA, Dobretsov M. Preclinical assessment of utility of M6S for multimodal acute and chronic pain treatment in diabetic neuropathy. Life Sci. 2018 Jan 01; 192:151-159. PMID: 29191644.
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Hankosky ER, Joolakanti SR, Nickell JR, Janganati V, Dwoskin LP, Crooks PA. Fluoroethoxy-1,4-diphenethylpiperidine and piperazine derivatives: Potent and selective inhibitors of [3H]dopamine uptake at the vesicular monoamine transporter-2. Bioorg Med Chem Lett. 2017 12 15; 27(24):5467-5472. PMID: 29153425.
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Wang R, Bhat-Nakshatri P, Padua MB, Prasad MS, Anjanappa M, Jacobson M, Finnearty C, Sefcsik V, McElyea K, Redmond R, Sandusky G, Penthala N, Crooks PA, Liu J, Zimmers T, Nakshatri H. Pharmacological Dual Inhibition of Tumor and Tumor-Induced Functional Limitations in a Transgenic Model of Breast Cancer. Mol Cancer Ther. 2017 Dec; 16(12):2747-2758. PMID: 28978719.
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Yadlapalli JSK, Dogra N, Walbaum AW, Wessinger WD, Prather PL, Crooks PA, Dobretsov M. Evaluation of Analgesia, Tolerance, and the Mechanism of Action of Morphine-6-O-Sulfate Across Multiple Pain Modalities in Sprague-Dawley Rats. Anesth Analg. 2017 09; 125(3):1021-1031. PMID: 28489639.
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Ford BM, Franks LN, Tai S, Fantegrossi WE, Stahl EL, Berquist MD, Cabanlong CV, Wilson CD, Penthala NR, Crooks PA, Prather PL. Characterization of structurally novel G protein biased CB1 agonists: Implications for drug development. Pharmacol Res. 2017 Nov; 125(Pt B):161-177. PMID: 28838808.
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Mendonca MS, Turchan WT, Alpuche ME, Watson CN, Estabrook NC, Chin-Sinex H, Shapiro JB, Imasuen-Williams IE, Rangel G, Gilley DP, Huda N, Crooks PA, Shapiro RH. DMAPT inhibits NF-?B activity and increases sensitivity of prostate cancer cells to X-rays in vitro and in tumor xenografts in vivo. Free Radic Biol Med. 2017 11; 112:318-326. PMID: 28782644.
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Walbaum A, Fifer EK, Parkin S, Crooks PA. Crystal structure of 4,4'-bis-[3-(piperidin-1-yl)prop-1-yn-1-yl]-1,1'-biphen-yl. Acta Crystallogr E Crystallogr Commun. 2017 Jun 01; 73(Pt 6):864-866. PMID: 28638646.
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Bommagani S, Ponder J, Penthala NR, Janganati V, Jordan CT, Borrelli MJ, Crooks PA. Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells. Eur J Med Chem. 2017 Aug 18; 136:393-405. PMID: 28525840.
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Janganati V, Ponder J, Thakkar S, Jordan CT, Crooks PA. Succinamide derivatives of melampomagnolide B and their anti-cancer activities. Bioorg Med Chem. 2017 07 15; 25(14):3694-3705. PMID: 28545815.
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Yadlapalli JSK, Albayati ZAF, Penthala NR, Hendrickson HP, Crooks PA. Stability studies of potent opioid analgesic, morphine-6-O-sulfate in various buffers and biological matrices by HPLC-DAD analysis. Biomed Chromatogr. 2017 Sep; 31(9). PMID: 28205234.
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Al-Ghananeem AM, Malkawi AH, Crooks PA. Effect of pH on sublingual absorption of oxycodone hydrochloride. AAPS PharmSciTech. 2006 Mar; 7(1):E163-E167. PMID: 28290038.
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Albayati ZAF, Janganati V, Chen Z, Ponder J, Breen PJ, Jordan CT, Crooks PA. Identification of a melampomagnolide B analog as a potential lead molecule for treatment of acute myelogenous leukemia. Bioorg Med Chem. 2017 02 01; 25(3):1235-1241. PMID: 28049618.
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Nickell JR, Siripurapu KB, Horton DB, Zheng G, Crooks PA, Dwoskin LP. GZ-793A inhibits the neurochemical effects of methamphetamine via a selective interaction with the vesicular monoamine transporter-2. Eur J Pharmacol. 2017 Jan 15; 795:143-149. PMID: 27986625.
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Pei S, Minhajuddin M, D'Alessandro A, Nemkov T, Stevens BM, Adane B, Khan N, Hagen FK, Yadav VK, De S, Ashton JM, Hansen KC, Gutman JA, Pollyea DA, Crooks PA, Smith C, Jordan CT. Rational design of a parthenolide-based drug regimen that selectively eradicates acute myelogenous leukemia stem cells. J Biol Chem. 2016 11 25; 291(48):25280. PMID: 27888238.
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Smith CA, Mont S, Traver G, Sekhar KR, Crooks PA, Freeman ML. Targeting Enox1 in tumor stroma increases the efficacy of fractionated radiotherapy. Oncotarget. 2016 Nov 22; 7(47):77926-77936. PMID: 27788492.
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Penthala NR, Janganati V, Alpe TL, Apana SM, Berridge MS, Crooks PA, Borrelli MJ. N-[11CH3]Dimethylaminoparthenolide (DMAPT) uptake into orthotopic 9LSF glioblastoma tumors in the rat. Bioorg Med Chem Lett. 2016 12 15; 26(24):5883-5886. PMID: 27866815.
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Yadlapalli JSK, Ford BM, Ketkar A, Wan A, Penthala NR, Eoff RL, Prather PL, Dobretsov M, Crooks PA. Antinociceptive effects of the 6-O-sulfate ester of morphine in normal and diabetic rats: Comparative role of mu- and delta-opioid receptors. Pharmacol Res. 2016 11; 113(Pt A):335-347. PMID: 27637375.
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Pei S, Minhajuddin M, D'Alessandro A, Nemkov T, Stevens BM, Adane B, Khan N, Hagen FK, Yadav VK, De S, Ashton JM, Hansen KC, Gutman JA, Pollyea DA, Crooks PA, Smith C, Jordan CT. Rational Design of a Parthenolide-based Drug Regimen That Selectively Eradicates Acute Myelogenous Leukemia Stem Cells. J Biol Chem. 2016 Oct 14; 291(42):21984-22000. PMID: 27573247.
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Han YS, Penthala NR, Oliveira M, Mespl?de T, Xu H, Quan Y, Crooks PA, Wainberg MA. Identification of resveratrol analogs as potent anti-dengue agents using a cell-based assay. J Med Virol. 2017 03; 89(3):397-407. PMID: 27509184.
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Nickell JR, Culver JP, Janganati V, Zheng G, Dwoskin LP, Crooks PA. Synthesis and in vitro evaluation of water-soluble 1,4-diphenethylpiperazine analogs as novel inhibitors of the vesicular monoamine transporter-2. Bioorg Med Chem Lett. 2016 09 15; 26(18):4441-4445. PMID: 27524311.
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Laxmi SV, Anil P, Rajitha G, Rao AJ, Crooks PA, Rajitha B. Synthesis of thiazolidine-2,4-dione derivatives: anticancer, antimicrobial and DNA cleavage studies. J Chem Biol. 2016 Oct; 9(4):97-106. PMID: 27698947.
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Sau A, Lau R, Cabrita MA, Nolan E, Crooks PA, Visvader JE, Pratt MA. Persistent Activation of NF-?B in BRCA1-Deficient Mammary Progenitors Drives Aberrant Proliferation and Accumulation of DNA Damage. Cell Stem Cell. 2016 07 07; 19(1):52-65. PMID: 27292187.
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Liu X, Gujarathi S, Zhang X, Shao L, Boerma M, Compadre CM, Crooks PA, Hauer-Jensen M, Zhou D, Zheng G. Synthesis of (2R,8' S,3' E)-d-tocodienol, a tocoflexol family member designed to have a superior pharmacokinetic profile compared to d-tocotrienol. Tetrahedron. 2016 Jul; 72(27-28):4001-4006. PMID: 27773949.
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Nickell JR, Culver JP, Janganati V, Zheng G, Dwoskin LP, Crooks PA. 1,4-Diphenalkylpiperidines: A new scaffold for the design of potent inhibitors of the vesicular monoamine transporter-2. Bioorg Med Chem Lett. 2016 07 01; 26(13):2997-3000. PMID: 27212067.
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Penthala NR, Yadlapalli JK, Parkin S, Crooks PA. Crystal structures of (Z)-5-[2-(benzo[b]thio-phen-2-yl)-1-(3,5-di-meth-oxy-phen-yl)ethen-yl]-1H-tetra-zole and (Z)-5-[2-(benzo[b]thio-phen-3-yl)-1-(3,4,5-tri-meth-oxy-phen-yl)ethen-yl]-1H-tetra-zole. Acta Crystallogr E Crystallogr Commun. 2016 May 01; 72(Pt 5):652-5. PMID: 27308011.
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Joolakanti SR, Nickell JR, Janganati V, Zheng G, Dwoskin LP, Crooks PA. Lobelane analogues containing 4-hydroxy and 4-(2-fluoroethoxy) aromatic substituents: Potent and selective inhibitors of [(3)H]dopamine uptake at the vesicular monoamine transporter-2. Bioorg Med Chem Lett. 2016 05 15; 26(10):2422-2427. PMID: 27080180.
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Madadi NR, Ketkar A, Penthala NR, Bostian AC, Eoff RL, Crooks PA. Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells. Bioorg Med Chem Lett. 2016 May 01; 26(9):2164-9. PMID: 27017113.
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Albayati ZA, Sunkara M, Schmidt-Malan SM, Karau MJ, Morris AJ, Steckelberg JM, Patel R, Breen PJ, Smeltzer MS, Taylor KG, Merten KE, Pierce WM, Crooks PA. Novel Bone-Targeting Agent for Enhanced Delivery of Vancomycin to Bone. Antimicrob Agents Chemother. 2015 Dec 14; 60(3):1865-8. PMID: 26666918.
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Bommagani S, Penthala NR, Parkin S, Crooks PA. Crystal structure of (E)-13-(pyrimidin-5-yl)parthenolide. Acta Crystallogr E Crystallogr Commun. 2015 Dec 01; 71(Pt 12):1536-8. PMID: 26870423.
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Janganati V, Ponder J, Jordan CT, Borrelli MJ, Penthala NR, Crooks PA. Dimers of Melampomagnolide B Exhibit Potent Anticancer Activity against Hematological and Solid Tumor Cells. J Med Chem. 2015 Nov 25; 58(22):8896-906. PMID: 26540463.
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Penthala NR, Ketkar A, Sekhar KR, Freeman ML, Eoff RL, Balusu R, Crooks PA. 1-Benzyl-2-methyl-3-indolylmethylene barbituric acid derivatives: Anti-cancer agents that target nucleophosmin 1 (NPM1). Bioorg Med Chem. 2015 Nov 15; 23(22):7226-33. PMID: 26602084.
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Wan A, Penthala NR, Fifer EK, Parkin S, Crooks PA. Comparison of the crystal structures of 4,4'-bis-[3-(4-methyl-piperidin-1-yl)prop-1-yn-1-yl]-1,1'-biphenyl and 4,4'-bis-[3-(2,2,6,6-tetra-methyl-piperidin-1-yl)prop-1-yn-1-yl]-1,1'-biphen-yl. Acta Crystallogr E Crystallogr Commun. 2015 Oct 01; 71(Pt 10):1132-5. PMID: 26594389.
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Wan A, Penthala NR, Fifer EK, Parkin S, Crooks PA. Comparison crystal structure conformations of two structurally related biphenyl analogues: 4,4'-bis-[3-(pyrrolidin-1-yl)prop-1-yn-1-yl]-1,1'-biphenyl and 4,4'-bis-{3-[(S)-2-methyl-pyrrolidin-1-yl]prop-1-yn-1-yl}-1,1'-biphen-yl. Acta Crystallogr E Crystallogr Commun. 2015 Oct 01; 71(Pt 10):1147-50. PMID: 26594393.
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Madadi NR, Penthala NR, Howk K, Ketkar A, Eoff RL, Borrelli MJ, Crooks PA. Synthesis and biological evaluation of novel 4,5-disubstituted 2H-1,2,3-triazoles as cis-constrained analogues of combretastatin A-4. Eur J Med Chem. 2015 Oct 20; 103:123-32. PMID: 26352674.
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Zheng G, Crooks PA. Synthesis of Lobeline, Lobelane and their Analogues. A Review. Org Prep Proced Int. 2015; 47(5):317-337. PMID: 26858465.
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Beckmann JS, Meyer AC, Pivavarchyk M, Horton DB, Zheng G, Smith AM, Wooters TE, McIntosh JM, Crooks PA, Bardo MT, Dwoskin LP. r-bPiDI, an a6?2* Nicotinic Receptor Antagonist, Decreases Nicotine-Evoked Dopamine Release and Nicotine Reinforcement. Neurochem Res. 2015 Oct; 40(10):2121-30. PMID: 26227997.
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Penthala NR, Madhukuri L, Thakkar S, Madadi NR, Lamture G, Eoff RL, Crooks PA. Synthesis and anti-cancer screening of novel heterocyclic-(2H)-1,2,3-triazoles as potential anti-cancer agents. Medchemcomm. 2015 Aug 01; 6(8):1535-1543. PMID: 27066215.
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Burnett RM, Craven KE, Krishnamurthy P, Goswami CP, Badve S, Crooks P, Mathews WP, Bhat-Nakshatri P, Nakshatri H. Organ-specific adaptive signaling pathway activation in metastatic breast cancer cells. Oncotarget. 2015 May 20; 6(14):12682-96. PMID: 25926557.
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Penthala NR, Thakkar S, Crooks PA. Heteroaromatic analogs of the resveratrol analog DMU-212 as potent anti-cancer agents. Bioorg Med Chem Lett. 2015 Jul 15; 25(14):2763-7. PMID: 26022840.
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Ding D, Nickell JR, Dwoskin LP, Crooks PA. Quinolyl analogues of norlobelane: novel potent inhibitors of [(3)H]dihydrotetrabenazine binding and [(3)H]dopamine uptake at the vesicular monoamine transporter-2. Bioorg Med Chem Lett. 2015 Jul 01; 25(13):2613-6. PMID: 25991431.
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Madadi NR, Zong H, Ketkar A, Zheng C, Penthala NR, Janganati V, Bommagani S, Eoff RL, Guzman ML, Crooks PA. Synthesis and evaluation of a series of resveratrol analogues as potent anti-cancer agents that target tubulin. Medchemcomm. 2015 May 01; 6(3):788-794. PMID: 26257861.
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Penthala NR, Crooks PA, Freeman ML, Sekhar KR. Development and validation of a novel assay to identify radiosensitizers that target nucleophosmin 1. Bioorg Med Chem. 2015 Jul 01; 23(13):3681-6. PMID: 25922180.
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Holt JC, Kewin K, Jordan PM, Cameron P, Klapczynski M, McIntosh JM, Crooks PA, Dwoskin LP, Lysakowski A. Pharmacologically distinct nicotinic acetylcholine receptors drive efferent-mediated excitation in calyx-bearing vestibular afferents. J Neurosci. 2015 Feb 25; 35(8):3625-43. PMID: 25716861.
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Penthala NR, Zong H, Ketkar A, Madadi NR, Janganati V, Eoff RL, Guzman ML, Crooks PA. Synthesis, anticancer activity and molecular docking studies on a series of heterocyclic trans-cyanocombretastatin analogues as antitubulin agents. Eur J Med Chem. 2015 Mar 06; 92:212-20. PMID: 25557492.
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Jang DS, Penthala NR, Apostolov EO, Wang X, Crooks PA, Basnakian AG. Novel cytoprotective inhibitors for apoptotic endonuclease G. DNA Cell Biol. 2015 Feb; 34(2):92-100. PMID: 25401220.
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Gali R, Banothu J, Gondru R, Bavantula R, Velivela Y, Crooks PA. One-pot multicomponent synthesis of indole incorporated thiazolylcoumarins and their antibacterial, anticancer and DNA cleavage studies. Bioorg Med Chem Lett. 2015 Jan 01; 25(1):106-12. PMID: 25435148.
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Penthala NR, Madadi NR, Bommagani S, Parkin S, Crooks PA. Comparison of crystal structures of 4-(benzo[b]thio-phen-2-yl)-5-(3,4,5-tri-meth-oxy-phen-yl)-2H-1,2,3-triazole and 4-(benzo[b]thio-phen-2-yl)-2-methyl-5-(3,4,5-tri-meth-oxy-phen-yl)-2H-1,2,3-triazole. Acta Crystallogr Sect E Struct Rep Online. 2014 Nov 01; 70(Pt 11):392-5. PMID: 25484755.
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Jang DS, Penthala NR, Apostolov EO, Wang X, Fahmi T, Crooks PA, Basnakian AG. Novel high-throughput deoxyribonuclease 1 assay. J Biomol Screen. 2015 Feb; 20(2):202-11. PMID: 25326282.
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Eldridge JA, Milewski M, Stinchcomb AL, Crooks PA. Synthesis and in vitro stability of amino acid prodrugs of 6-?-naltrexol for microneedle-enhanced transdermal delivery. Bioorg Med Chem Lett. 2014 Nov 15; 24(22):5212-5. PMID: 25442314.
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Penthala NR, Madadi NR, Janganati V, Crooks PA. L-Proline catalyzed one-step synthesis of 4,5-diaryl-2H-1,2,3-triazoles from heteroaryl cyanostilbenes via [3+2] cycloaddition of azide. Tetrahedron Lett. 2014 Oct 01; 55(40):5562-5565. PMID: 25267862.
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Madadi NR, Penthala NR, Bommagani S, Parkin S, Crooks PA. Crystal structure of 4,5-bis-(3,4,5-tri-meth-oxy-phen-yl)-2H-1,2,3-triazole methanol monosolvate. Acta Crystallogr Sect E Struct Rep Online. 2014 Oct 01; 70(Pt 10):o1128-9. PMID: 25484710.
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Penthala NR, Bommagani S, Janganati V, Parkin S, Crooks PA. Crystal structure of (E)-13-{4-[(Z)-2-cyano-2-(3,4,5-tri-meth-oxy-phen-yl)ethen-yl]phen-yl}parthenolide methanol hemisolvate. Acta Crystallogr Sect E Struct Rep Online. 2014 Oct 01; 70(Pt 10):o1092-3. PMID: 25484689.
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Penthala NR, Bommagani S, Janganati V, MacNicol KB, Cragle CE, Madadi NR, Hardy LL, MacNicol AM, Crooks PA. Heck products of parthenolide and melampomagnolide-B as anticancer modulators that modify cell cycle progression. Eur J Med Chem. 2014 Oct 06; 85:517-25. PMID: 25117652.
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Sekhar KR, Benamar M, Venkateswaran A, Sasi S, Penthala NR, Crooks PA, Hann SR, Geng L, Balusu R, Abbas T, Freeman ML. Targeting nucleophosmin 1 represents a rational strategy for radiation sensitization. Int J Radiat Oncol Biol Phys. 2014 Aug 01; 89(5):1106-1114. PMID: 25035215.
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Janganati V, Penthala NR, Madadi NR, Chen Z, Crooks PA. Anti-cancer activity of carbamate derivatives of melampomagnolide B. Bioorg Med Chem Lett. 2014 Aug 01; 24(15):3499-502. PMID: 24928404.
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Franks LN, Ford BM, Madadi NR, Penthala NR, Crooks PA, Prather PL. Characterization of the intrinsic activity for a novel class of cannabinoid receptor ligands: Indole quinuclidine analogs. Eur J Pharmacol. 2014 Aug 15; 737:140-8. PMID: 24858620.
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Greer AK, Madadi NR, Bratton SM, Eddy SD, Mazerska Z, Hendrickson HP, Crooks PA, Radominska-Pandya A. Novel resveratrol-based substrates for human hepatic, renal, and intestinal UDP-glucuronosyltransferases. Chem Res Toxicol. 2014 Apr 21; 27(4):536-45. PMID: 24571610.
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Janganati V, Penthala NR, Cragle CE, MacNicol AM, Crooks PA. Heterocyclic aminoparthenolide derivatives modulate G(2)-M cell cycle progression during Xenopus oocyte maturation. Bioorg Med Chem Lett. 2014 Apr 15; 24(8):1963-7. PMID: 24656611.
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Peters V, Crooks P, Rutkowski M, Cairoli O. Vascular access management: ongoing challenges and strategies for success. Nephrol News Issues. 2014 Mar; 28(3):26, 28, 30-3. PMID: 24720013.
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Janganati V, Penthala NR, Madadi NR, Parkin S, Crooks PA. Monosuccinate ester of melampomagnolide B. Acta Crystallogr Sect E Struct Rep Online. 2014 Mar 01; 70(Pt 3):o372-3. PMID: 24765054.
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Penthala NR, Bommagani S, Janganati V, Parkin S, Crooks PA. (E)-13-(2-Bromo-phen-yl)micheliolide. Acta Crystallogr Sect E Struct Rep Online. 2014 Mar 01; 70(Pt 3):o251-2. PMID: 24764970.
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Nickell JR, Siripurapu KB, Vartak A, Crooks PA, Dwoskin LP. The vesicular monoamine transporter-2: an important pharmacological target for the discovery of novel therapeutics to treat methamphetamine abuse. Adv Pharmacol. 2014; 69:71-106. PMID: 24484975.
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Crooks PA, Bardo MT, Dwoskin LP. Nicotinic receptor antagonists as treatments for nicotine abuse. Adv Pharmacol. 2014; 69:513-51. PMID: 24484986.
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Madadi NR, Penthala NR, Janganati V, Crooks PA. Synthesis and anti-proliferative activity of aromatic substituted 5-((1-benzyl-1H-indol-3-yl)methylene)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione analogs against human tumor cell lines. Bioorg Med Chem Lett. 2014 Jan 15; 24(2):601-3. PMID: 24361000.
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Bommagani S, Penthala NR, Janganati V, Parkin S, Crooks PA. 13-(N,N-Di-methyl-amino)-micheliolide 0.08-hydrate. Acta Crystallogr Sect E Struct Rep Online. 2013 Nov 20; 69(Pt 12):o1789-90. PMID: 24454230.
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Venkateswaran A, Sekhar KR, Levic DS, Melville DB, Clark TA, Rybski WM, Walsh AJ, Skala MC, Crooks PA, Knapik EW, Freeman ML. The NADH oxidase ENOX1, a critical mediator of endothelial cell radiosensitization, is crucial for vascular development. Cancer Res. 2014 Jan 01; 74(1):38-43. PMID: 24247717.
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Janganati V, Penthala NR, Parkin S, Crooks PA. 13-(Imidazol-1-yl)-11,13-di-hydro-melampomagnolide B monohydrate. Acta Crystallogr Sect E Struct Rep Online. 2013 Nov 06; 69(Pt 12):o1734-5. PMID: 24454194.
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Penthala NR, Janganati V, Parkin S, Varughese KI, Crooks PA. (E)-13-(4-Amino-phen-yl)parthenolide. Acta Crystallogr Sect E Struct Rep Online. 2013 Oct 26; 69(Pt 11):o1709-10. PMID: 24454134.
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Pei S, Minhajuddin M, Callahan KP, Balys M, Ashton JM, Neering SJ, Lagadinou ED, Corbett C, Ye H, Liesveld JL, O'Dwyer KM, Li Z, Shi L, Greninger P, Settleman J, Benes C, Hagen FK, Munger J, Crooks PA, Becker MW, Jordan CT. Targeting aberrant glutathione metabolism to eradicate human acute myelogenous leukemia cells. J Biol Chem. 2013 Nov 22; 288(47):33542-33558. PMID: 24089526.
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Wilmouth CE, Zheng G, Crooks PA, Dwoskin LP, Bardo MT. Oral administration of GZ-793A, a VMAT2 inhibitor, decreases methamphetamine self-administration in rats. Pharmacol Biochem Behav. 2013 Nov; 112:29-33. PMID: 24075974.
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Ding D, Dwoskin LP, Crooks PA. Efficient synthesis of cis-2,6-di-(2- quinolylpiperidine). Tetrahedron Lett. 2013 Sep 18; 54(38):5211-5213. PMID: 24511163.
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Banothu J, Gali R, Velpula R, Bavantula R, Crooks PA. An Eco-Friendly Improved Protocol for the Synthesis of Bis(3-indolyl)methanes Using Poly(4-vinylpyridinium)hydrogen Sulfate as Efficient, Heterogeneous, and Recyclable Solid Acid Catalyst. ISRN Org Chem. 2013; 2013:616932. PMID: 24052864.
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Meyer AC, Neugebauer NM, Zheng G, Crooks PA, Dwoskin LP, Bardo MT. Effects of VMAT2 inhibitors lobeline and GZ-793A on methamphetamine-induced changes in dopamine release, metabolism and synthesis in vivo. J Neurochem. 2013 Oct; 127(2):187-98. PMID: 23875705.
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Horton DB, Nickell JR, Zheng G, Crooks PA, Dwoskin LP. GZ-793A, a lobelane analog, interacts with the vesicular monoamine transporter-2 to inhibit the effect of methamphetamine. J Neurochem. 2013 Oct; 127(2):177-86. PMID: 23875622.
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Ding D, Nickell JR, Deaciuc AG, Penthala NR, Dwoskin LP, Crooks PA. Synthesis and evaluation of novel azetidine analogs as potent inhibitors of vesicular [3H]dopamine uptake. Bioorg Med Chem. 2013 Nov 01; 21(21):6771-7. PMID: 23993667.
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Peng C, Kimbrell MR, Tian C, Pack TF, Crooks PA, Fifer EK, Papke RL. Multiple modes of a7 nAChR noncompetitive antagonism of control agonist-evoked and allosterically enhanced currents. Mol Pharmacol. 2013 Sep; 84(3):459-75. PMID: 23839567.
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Penthala NR, Sonar VN, Horn J, Leggas M, Yadlapalli JS, Crooks PA. Synthesis and evaluation of a series of benzothiophene acrylonitrile analogs as anticancer agents. Medchemcomm. 2013 Jul 01; 4(7):1073-1078. PMID: 23956835.
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Coggins GE, Maddukuri L, Penthala NR, Hartman JH, Eddy S, Ketkar A, Crooks PA, Eoff RL. N-Aroyl indole thiobarbituric acids as inhibitors of DNA repair and replication stress response polymerases. ACS Chem Biol. 2013 Aug 16; 8(8):1722-9. PMID: 23679919.
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Xu Y, Fang F, Miriyala S, Crooks PA, Oberley TD, Chaiswing L, Noel T, Holley AK, Zhao Y, Kiningham KK, Clair DK, Clair WH. KEAP1 is a redox sensitive target that arbitrates the opposing radiosensitive effects of parthenolide in normal and cancer cells. Cancer Res. 2013 Jul 15; 73(14):4406-17. PMID: 23674500.
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Yip-Schneider MT, Wu H, Stantz K, Agaram N, Crooks PA, Schmidt CM. Dimethylaminoparthenolide and gemcitabine: a survival study using a genetically engineered mouse model of pancreatic cancer. BMC Cancer. 2013 Apr 17; 13:194. PMID: 23590467.
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Penthala NR, Ponugoti PR, Nickell JR, Deaciuc AG, Dwoskin LP, Crooks PA. Pyrrolidine analogs of GZ-793A: synthesis and evaluation as inhibitors of the vesicular monoamine transporter-2 (VMAT2). Bioorg Med Chem Lett. 2013 Jun 01; 23(11):3342-5. PMID: 23597792.
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Zheng G, Horton DB, Penthala NR, Nickell JR, Culver JP, Deaciuc AG, Dwoskin LP, Crooks PA. Exploring the effect of N-substitution in nor-lobelane on the interaction with VMAT2: discovery of a potential clinical candidate for treatment of methamphetamine abuse. Medchemcomm. 2013 Mar; 4(3):564-568. PMID: 23527317.
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Madadi NR, Penthala NR, Brents LK, Ford BM, Prather PL, Crooks PA. Evaluation of (Z)-2-((1-benzyl-1H-indol-3-yl)methylene)-quinuclidin-3-one analogues as novel, high affinity ligands for CB1 and CB2 cannabinoid receptors. Bioorg Med Chem Lett. 2013 Apr 01; 23(7):2019-21. PMID: 23466226.
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Ring JR, Zheng F, Haubner AJ, Littleton JM, Crooks PA. Improving the inhibitory activity of arylidenaminoguanidine compounds at the N-methyl-D-aspartate receptor complex from a recursive computational-experimental structure-activity relationship study. Bioorg Med Chem. 2013 Apr 01; 21(7):1764-74. PMID: 23465801.
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Penthala NR, Crooks PA. rac-N-Benzyl-isatincreatinine (unknown solvate). Acta Crystallogr Sect E Struct Rep Online. 2013 Feb 01; 69(Pt 2):o290-1. PMID: 23424560.
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Penthala NR, Crooks PA. rac-5-Bromo-N-benzyl-isatincreatinine ethanol monosolvate. Acta Crystallogr Sect E Struct Rep Online. 2013 Feb 01; 69(Pt 2):o288-9. PMID: 23424559.
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Yip-Schneider MT, Wu H, Hruban RH, Lowy AM, Crooks PA, Schmidt CM. Efficacy of dimethylaminoparthenolide and sulindac in combination with gemcitabine in a genetically engineered mouse model of pancreatic cancer. Pancreas. 2013 Jan; 42(1):160-7. PMID: 22699205.
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Adeneye Adejuwon A, Crooks PA, Fadhel-Albayati Z, Miller AF, Zito SW, Adeyemi OO, Agbaje EO. Antihyperglycemic profile of erinidine isolated from Hunteria umbellata seed. Afr J Tradit Complement Altern Med. 2013; 10(2):189-202. PMID: 24146442.
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Penthala NR, Ponugoti PR, Kasam V, Crooks PA. 5-((1-Aroyl-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-diones as potential anticancer agents with anti-inflammatory properties. Bioorg Med Chem Lett. 2013 Mar 01; 23(5):1442-6. PMID: 23339966.
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Sonar VN, Parkin S, Crooks PA. Oxycodone N-oxide. Acta Crystallogr C. 2012 Nov; 68(Pt 11):o436-8. PMID: 23124457.
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Penthala NR, Ponugoti PR, Parkin S, Crooks PA. rac-(Z)-Methyl 1-benzyl-3-[(3-hy-droxy-quinuclidin-2-yl-idene)meth-yl]-1H-indole-6-carboxyl-ate. Acta Crystallogr Sect E Struct Rep Online. 2012 Nov 01; 68(Pt 11):o3111. PMID: 23284437.
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Venkateswaran A, Friedman DB, Walsh AJ, Skala MC, Sasi S, Rachakonda G, Crooks PA, Freeman ML, Sekhar KR. The novel antiangiogenic VJ115 inhibits the NADH oxidase ENOX1 and cytoskeleton-remodeling proteins. Invest New Drugs. 2013 Jun; 31(3):535-44. PMID: 23054211.
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Sonar VN, Parkin S, Crooks PA. The effect of hydrogen bonding on the conformations of 2-(1H-indol-3-yl)-2-oxoacetamide and 2-(1H-indol-3-yl)-N,N-dimethyl-2-oxoacetamide. Acta Crystallogr C. 2012 Oct; 68(Pt 10):o405-7. PMID: 23007543.
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Barron S, Lewis B, Wellmann K, Carter M, Farook J, Ring J, Rogers DT, Holley R, Crooks P, Littleton J. Polyamine modulation of NMDARs as a mechanism to reduce effects of alcohol dependence. Recent Pat CNS Drug Discov. 2012 Aug; 7(2):129-44. PMID: 22574674.
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Alvers KM, Beckmann JS, Zheng G, Crooks PA, Dwoskin LP, Bardo MT. The effect of VMAT2 inhibitor GZ-793A on the reinstatement of methamphetamine-seeking in rats. Psychopharmacology (Berl). 2012 Nov; 224(2):255-62. PMID: 22638813.
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Holcomb BK, Yip-Schneider MT, Waters JA, Beane JD, Crooks PA, Schmidt CM. Dimethylamino parthenolide enhances the inhibitory effects of gemcitabine in human pancreatic cancer cells. J Gastrointest Surg. 2012 Jul; 16(7):1333-40. PMID: 22618517.
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Wala EP, Crooks PA, McIntosh JM, Holtman JR. Novel small molecule a9a10 nicotinic receptor antagonist prevents and reverses chemotherapy-evoked neuropathic pain in rats. Anesth Analg. 2012 Sep; 115(3):713-20. PMID: 22610850.
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Penthala NR, Parkin S, Crooks PA. (Z)-3-(1H-Indol-3-yl)-2-(3,4,5-tri-methoxy-phen-yl)acrylonitrile. Acta Crystallogr Sect E Struct Rep Online. 2012 Mar 01; 68(Pt 3):o729. PMID: 22412611.
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Madadi NR, Parkin S, Crooks PA. (Z)-2-{2,4-Dimeth-oxy-6-[(E)-4-meth-oxy-styr-yl]benzyl-idene}quinuclidin-3-one. Acta Crystallogr Sect E Struct Rep Online. 2012 Mar 01; 68(Pt 3):o730. PMID: 22412612.
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Penthala NR, Parkin S, Crooks PA. (Z)-3-(1-Benzofuran-2-yl)-2-(3,4,5-tri-meth-oxy-phen-yl)acrylonitrile. Acta Crystallogr Sect E Struct Rep Online. 2012 Mar 01; 68(Pt 3):o731. PMID: 22412613.
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Estabrook NC, Chin-Sinex H, Borgmann AJ, Dhaemers RM, Shapiro RH, Gilley D, Huda N, Crooks P, Sweeney C, Mendonca MS. Inhibition of NF-?B and DNA double-strand break repair by DMAPT sensitizes non-small-cell lung cancers to X-rays. Free Radic Biol Med. 2011 Dec 15; 51(12):2249-58. PMID: 22019440.
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Beckmann JS, Denehy ED, Zheng G, Crooks PA, Dwoskin LP, Bardo MT. The effect of a novel VMAT2 inhibitor, GZ-793A, on methamphetamine reward in rats. Psychopharmacology (Berl). 2012 Mar; 220(2):395-403. PMID: 21938414.
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Holtman JR, Dwoskin LP, Dowell C, Wala EP, Zhang Z, Crooks PA, McIntosh JM. The novel small molecule a9a10 nicotinic acetylcholine receptor antagonist ZZ-204G is analgesic. Eur J Pharmacol. 2011 Nov 30; 670(2-3):500-8. PMID: 21944926.
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Sekhar KR, Reddy YT, Reddy PN, Crooks PA, Venkateswaran A, McDonald WH, Geng L, Sasi S, Van Der Waal RP, Roti JL, Salleng KJ, Rachakonda G, Freeman ML. The novel chemical entity YTR107 inhibits recruitment of nucleophosmin to sites of DNA damage, suppressing repair of DNA double-strand breaks and enhancing radiosensitization. Clin Cancer Res. 2011 Oct 15; 17(20):6490-9. PMID: 21878537.
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Horton DB, Siripurapu KB, Zheng G, Crooks PA, Dwoskin LP. Novel N-1,2-dihydroxypropyl analogs of lobelane inhibit vesicular monoamine transporter-2 function and methamphetamine-evoked dopamine release. J Pharmacol Exp Ther. 2011 Oct; 339(1):286-97. PMID: 21778282.
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Nasim S, Guzman ML, Jordan CT, Crooks PA. Discovery of 1,2,4-thiadiazolidine-3,5-dione analogs that exhibit unusual and selective rapid cell death kinetics against acute myelogenous leukemia cells in culture. Bioorg Med Chem Lett. 2011 Aug 15; 21(16):4879-83. PMID: 21757349.
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Vijaya Laxmi S, Thirupathi Reddy Y, Suresh Kuarm B, Narsimha Reddy P, Crooks PA, Rajitha B. Synthesis and evaluation of chromenyl barbiturates and thiobarbiturates as potential antitubercular agents. Bioorg Med Chem Lett. 2011 Jul 15; 21(14):4329-31. PMID: 21684158.
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Zhang Z, Dwoskin LP, Crooks PA. Expeditious synthesis of cis-1-methyl-2, 3,3a,4,5,9b-hexahydro-1H-pyrrolo-[3,2h]isoquinoline / [2,3-f]quinoline via azomethine ylide-alkene [3+2] cycloaddition. Tetrahedron Lett. 2011 May 25; 52(21):2667-2669. PMID: 23908558.
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Shanmugam R, Kusumanchi P, Appaiah H, Cheng L, Crooks P, Neelakantan S, Peat T, Klaunig J, Matthews W, Nakshatri H, Sweeney CJ. A water soluble parthenolide analog suppresses in vivo tumor growth of two tobacco-associated cancers, lung and bladder cancer, by targeting NF-?B and generating reactive oxygen species. Int J Cancer. 2011 May 15; 128(10):2481-94. PMID: 20669221.
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Wooters TE, Smith AM, Pivavarchyk M, Siripurapu KB, McIntosh JM, Zhang Z, Crooks PA, Bardo MT, Dwoskin LP. bPiDI: a novel selective a6?2* nicotinic receptor antagonist and preclinical candidate treatment for nicotine abuse. Br J Pharmacol. 2011 May; 163(2):346-57. PMID: 21232049.
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Biermann M, Hardcastle KI, Moskalev NV, Crooks PA. (S)-2-Amino-2-(2-chloro-phen-yl)cyclo-hexa-none. Acta Crystallogr Sect E Struct Rep Online. 2011 Apr 01; 67(Pt 4):o936. PMID: 21754205.
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Ponugoti PR, Penthala NR, Dwoskin LP, Parkin S, Crooks PA. cis-1-Benzyl-pyrrolidine-2,5-dicarbonitrile. Acta Crystallogr Sect E Struct Rep Online. 2011 Apr 01; 67(Pt 4):o747. PMID: 21754044.
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Pivavarchyk M, Smith AM, Zhang Z, Zhou D, Wang X, Toyooka N, Tsuneki H, Sasaoka T, McIntosh JM, Crooks PA, Dwoskin LP. Indolizidine (-)-235B' and related structural analogs: discovery of nicotinic receptor antagonists that inhibit nicotine-evoked [3H]dopamine release. Eur J Pharmacol. 2011 May 11; 658(2-3):132-9. PMID: 21371454.
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Al-Ghananeem AM, Malkawi AH, Crooks PA. Bioavailability of ??-tetrahydrocannabinol following intranasal administration of a mucoadhesive gel spray delivery system in conscious rabbits. Drug Dev Ind Pharm. 2011 Mar; 37(3):329-34. PMID: 21244195.
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Ponugoti PR, Penthala NR, Dwoskin LP, Parkin S, Crooks PA. cis-2,5-Bis(2-fluoro-5-meth-oxy-pheneth-yl)pyrrolidinium formate. Acta Crystallogr Sect E Struct Rep Online. 2011 Feb 26; 67(Pt 3):o737. PMID: 21522476.
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Hojahmat M, Zheng G, Siegler M, Parkin S, Biermann M, Crooks PA. (S)-1-(2-Chloro-phen-yl)-2-oxocyclo-hexan-1-aminium d-tartrate. Acta Crystallogr Sect E Struct Rep Online. 2011 Feb 26; 67(Pt 3):o736. PMID: 21522475.
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Penthala NR, Reddy TR, Parkin S, Crooks PA. (2Z,3E)-2-{[1-(4-Chloro-benz-yl)-1H-indol-3-yl]methyl-idene}quinuclidin-3-one oxime. Acta Crystallogr Sect E Struct Rep Online. 2011 Feb 26; 67(Pt 3):o735. PMID: 21522474.
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Zheng G, Zhang Z, Dowell C, Wala E, Dwoskin LP, Holtman JR, McIntosh JM, Crooks PA. Discovery of non-peptide, small molecule antagonists of a9a10 nicotinic acetylcholine receptors as novel analgesics for the treatment of neuropathic and tonic inflammatory pain. Bioorg Med Chem Lett. 2011 Apr 15; 21(8):2476-9. PMID: 21397497.
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Penthala NR, Yerramreddy TR, Crooks PA. Synthesis and in vitro screening of novel N-benzyl aplysinopsin analogs as potential anticancer agents. Bioorg Med Chem Lett. 2011 Mar 01; 21(5):1411-3. PMID: 21295476.
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Nasim S, Pei S, Hagen FK, Jordan CT, Crooks PA. Melampomagnolide B: a new antileukemic sesquiterpene. Bioorg Med Chem. 2011 Feb 15; 19(4):1515-9. PMID: 21273084.
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Crooks PA, Zheng G, Vartak AP, Culver JP, Zheng F, Horton DB, Dwoskin LP. Design, synthesis and interaction at the vesicular monoamine transporter-2 of lobeline analogs: potential pharmacotherapies for the treatment of psychostimulant abuse. Curr Top Med Chem. 2011; 11(9):1103-27. PMID: 21050177.
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Horton DB, Siripurapu KB, Norrholm SD, Culver JP, Hojahmat M, Beckmann JS, Harrod SB, Deaciuc AG, Bardo MT, Crooks PA, Dwoskin LP. meso-Transdiene analogs inhibit vesicular monoamine transporter-2 function and methamphetamine-evoked dopamine release. J Pharmacol Exp Ther. 2011 Mar; 336(3):940-51. PMID: 21177475.
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Zhang Z, Zheng G, Pivavarchyk M, Deaciuc AG, Dwoskin LP, Crooks PA. Novel bis-, tris-, and tetrakis-tertiary amino analogs as antagonists at neuronal nicotinic receptors that mediate nicotine-evoked dopamine release. Bioorg Med Chem Lett. 2011 Jan 01; 21(1):88-91. PMID: 21147530.
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Kuarm BS, Reddy YT, Madhav JV, Crooks PA, Rajitha B. 3-[Benzimidazo- and 3-[benzothiadiazoleimidazo-(1,2-c)quinazolin-5-yl]-2H-chromene-2-ones as potent antimicrobial agents. Bioorg Med Chem Lett. 2011 Jan 01; 21(1):524-7. PMID: 21134751.
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Venkateswaran A, Reddy YT, Sonar VN, Muthusamy V, Crooks PA, Freeman ML, Sekhar KR. Antiangiogenic properties of substituted (Z)-(?)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-ol/one analogs and their derivatives. Bioorg Med Chem Lett. 2010 Dec 15; 20(24):7323-6. PMID: 21055930.
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Nasim S, Vartak AP, Pierce WM, Taylor KG, Smith N, Crooks PA. 3-O-phosphate ester conjugates of 17-?-O-{1-[2-carboxy-(2-hydroxy-4-methoxy-3-carboxamido)anilido]ethyl}1,3,5(10)-estratriene as novel bone-targeting agents. Bioorg Med Chem Lett. 2010 Dec 15; 20(24):7450-3. PMID: 21055931.
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Hassane DC, Sen S, Minhajuddin M, Rossi RM, Corbett CA, Balys M, Wei L, Crooks PA, Guzman ML, Jordan CT. Chemical genomic screening reveals synergism between parthenolide and inhibitors of the PI-3 kinase and mTOR pathways. Blood. 2010 Dec 23; 116(26):5983-90. PMID: 20889920.
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Nickell JR, Zheng G, Deaciuc AG, Crooks PA, Dwoskin LP. Phenyl ring-substituted lobelane analogs: inhibition of [?H]dopamine uptake at the vesicular monoamine transporter-2. J Pharmacol Exp Ther. 2011 Mar; 336(3):724-33. PMID: 20876747.
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Holtman JR, Crooks PA, Johnson-Hardy J, Wala EP. Antinociceptive effects and toxicity of morphine-6-O-sulfate sodium salt in rat models of pain. Eur J Pharmacol. 2010 Dec 01; 648(1-3):87-94. PMID: 20828549.
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Beckmann JS, Siripurapu KB, Nickell JR, Horton DB, Denehy ED, Vartak A, Crooks PA, Dwoskin LP, Bardo MT. The novel pyrrolidine nor-lobelane analog UKCP-110 [cis-2,5-di-(2-phenethyl)-pyrrolidine hydrochloride] inhibits VMAT2 function, methamphetamine-evoked dopamine release, and methamphetamine self-administration in rats. J Pharmacol Exp Ther. 2010 Dec; 335(3):841-51. PMID: 20805303.
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Shanmugam R, Kusumanchi P, Cheng L, Crooks P, Neelakantan S, Matthews W, Nakshatri H, Sweeney CJ. A water-soluble parthenolide analogue suppresses in vivo prostate cancer growth by targeting NFkappaB and generating reactive oxygen species. Prostate. 2010 Jul 01; 70(10):1074-86. PMID: 20209491.
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Banks SL, Pinninti RR, Gill HS, Paudel KS, Crooks PA, Brogden NK, Prausnitz MR, Stinchcomb AL. Transdermal delivery of naltrexol and skin permeability lifetime after microneedle treatment in hairless guinea pigs. J Pharm Sci. 2010 Jul; 99(7):3072-80. PMID: 20166200.
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Penthala NR, Eldridge J, Reddy TR, Parkin S, Crooks PA. (E,E)-1-Methyl-2,6-distyrylpyridinium iodide. Acta Crystallogr Sect E Struct Rep Online. 2010 Jun 26; 66(Pt 7):o1793. PMID: 21588003.
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Madadi NR, Reddy TR, Penthala NR, Parkin S, Crooks PA. (Z)-2-Amino-5-[2,4-dimeth-oxy-6-(4-methoxy-styr-yl)benzyl-idene]-1,3-thia-zol-4(5H)-one methanol solvate. Acta Crystallogr Sect E Struct Rep Online. 2010 Jun 26; 66(Pt 7):o1792. PMID: 21588002.
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Penthala NR, Yerramreddy TR, Madadi NR, Crooks PA. Synthesis and in vitro evaluation of N-alkyl-3-hydroxy-3-(2-imino-3-methyl-5-oxoimidazolidin-4-yl)indolin-2-one analogs as potential anticancer agents. Bioorg Med Chem Lett. 2010 Aug 01; 20(15):4468-71. PMID: 20598531.
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Milewski M, Yerramreddy TR, Ghosh P, Crooks PA, Stinchcomb AL. In vitro permeation of a pegylated naltrexone prodrug across microneedle-treated skin. J Control Release. 2010 Aug 17; 146(1):37-44. PMID: 20678989.
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Walsby EJ, Pratt G, Hewamana S, Crooks PA, Burnett AK, Fegan C, Pepper C. The NF-kappaB inhibitor LC-1 has single agent activity in multiple myeloma cells and synergizes with bortezomib. Mol Cancer Ther. 2010 Jun; 9(6):1574-82. PMID: 20515939.
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Vartak AP, Gabriela Deaciuc A, Dwoskin LP, Crooks PA. Quinlobelane: a water-soluble lobelane analogue and inhibitor of VMAT2. Bioorg Med Chem Lett. 2010 Jun 15; 20(12):3584-7. PMID: 20494575.
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Zheng G, Zhang Z, Lockman PR, Geldenhuys WJ, Allen DD, Dwoskin LP, Crooks PA. Bis-azaaromatic quaternary ammonium salts as ligands for the blood-brain barrier choline transporter. Bioorg Med Chem Lett. 2010 Jun 01; 20(11):3208-10. PMID: 20462759.
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Matharu J, Oki J, Worthen DR, Smith QR, Crooks PA. Regiospecific and conformationally restrained analogs of melphalan and DL-2-NAM-7 and their affinities for the large neutral amino acid transporter (system LAT1) of the blood-brain barrier. Bioorg Med Chem Lett. 2010 Jun 15; 20(12):3688-91. PMID: 20466543.
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Yerramreddy TR, Milewski M, Penthala NR, Stinchcomb AL, Crooks PA. Novel 3-O-pegylated carboxylate and 3-O-pegylated carbamate prodrugs of naltrexone for microneedle-enhanced transdermal delivery. Bioorg Med Chem Lett. 2010 Jun 01; 20(11):3280-3. PMID: 20451376.
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Thirupathi Reddy Y, Narsimha Reddy P, Koduru S, Damodaran C, Crooks PA. Aplysinopsin analogs: Synthesis and anti-proliferative activity of substituted (Z)-5-(N-benzylindol-3-ylmethylene)imidazolidine-2,4-diones. Bioorg Med Chem. 2010 May 15; 18(10):3570-4. PMID: 20403701.
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Smith AM, Pivavarchyk M, Wooters TE, Zhang Z, Zheng G, McIntosh JM, Crooks PA, Bardo MT, Dwoskin LP. Repeated nicotine administration robustly increases bPiDDB inhibitory potency at alpha6beta2-containing nicotinic receptors mediating nicotine-evoked dopamine release. Biochem Pharmacol. 2010 Aug 01; 80(3):402-9. PMID: 20346923.
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Sun Y, St Clair DK, Xu Y, Crooks PA, St Clair WH. A NADPH oxidase-dependent redox signaling pathway mediates the selective radiosensitization effect of parthenolide in prostate cancer cells. Cancer Res. 2010 Apr 01; 70(7):2880-90. PMID: 20233868.
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Zhang Z, Pivavarchyk M, Subramanian KL, Deaciuc AG, Dwoskin LP, Crooks PA. Novel bis-2,2,6,6-tetramethylpiperidine (bis-TMP) and bis-mecamylamine antagonists at neuronal nicotinic receptors mediating nicotine-evoked dopamine release. Bioorg Med Chem Lett. 2010 Feb 15; 20(4):1420-3. PMID: 20079634.
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Geldenhuys WJ, Manda VK, Mittapalli RK, Van der Schyf CJ, Crooks PA, Dwoskin LP, Allen DD, Lockman PR. Predictive screening model for potential vector-mediated transport of cationic substrates at the blood-brain barrier choline transporter. Bioorg Med Chem Lett. 2010 Feb 01; 20(3):870-7. PMID: 20053562.
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Vartak AP, Nickell JR, Chagkutip J, Dwoskin LP, Crooks PA. Pyrrolidine analogues of lobelane: relationship of affinity for the dihydrotetrabenazine binding site with function of the vesicular monoamine transporter 2 (VMAT2). J Med Chem. 2009 Dec 10; 52(23):7878-82. PMID: 19691331.
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Zheng G, Parkin S, Dwoskin LP, Crooks PA. (2S,6S)-1-Methyl-2,6-trans-distyryl-piperidinium chloride. Acta Crystallogr Sect E Struct Rep Online. 2009 Dec 09; 66(Pt 1):o78. PMID: 21580177.
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Zheng G, Parkin S, Dwoskin LP, Crooks PA. 1-Methyl-2,6-cis-distyrylpiperidine. Acta Crystallogr Sect E Struct Rep Online. 2009 Dec 09; 66(Pt 1):o77. PMID: 21580176.
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Hojahmat M, Horton DB, Norrholm SD, Miller DK, Grinevich VP, Deaciuc AG, Dwoskin LP, Crooks PA. Lobeline esters as novel ligands for neuronal nicotinic acetylcholine receptors and neurotransmitter transporters. Bioorg Med Chem. 2010 Jan 15; 18(2):640-9. PMID: 20036131.
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Penthala NR, Yerramreddy TR, Crooks PA. Microwave assisted synthesis and in vitro cytotoxicities of substituted (Z)-2-amino-5-(1-benzyl-1H-indol-3-yl)methylene-1-methyl-1H-imidazol-4(5H)-ones against human tumor cell lines. Bioorg Med Chem Lett. 2010 Jan 15; 20(2):591-3. PMID: 20006496.
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Reddy YT, Sekhar KR, Sasi N, Reddy PN, Freeman ML, Crooks PA. Novel substituted (Z)-5-((N-benzyl-1H-indol-3-yl)methylene)imidazolidine-2,4-diones and 5-((N-benzyl-1H-indol-3-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-triones as potent radio-sensitizing agents. Bioorg Med Chem Lett. 2010 Jan 15; 20(2):600-2. PMID: 20005706.
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Penthala NR, Reddy TR, Parkin S, Crooks PA. 3-(2-Amino-1-methyl-4-oxo-4,5-dihydro-1H-imidazol-5-yl)-5-fluoro-3-hydr-oxy-1-methyl-indolin-2-one methanol hemisolvate. Acta Crystallogr Sect E Struct Rep Online. 2009 Oct 31; 65(Pt 11):o2909-10. PMID: 21578489.
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Nickell JR, Krishnamurthy S, Norrholm S, Deaciuc G, Siripurapu KB, Zheng G, Crooks PA, Dwoskin LP. Lobelane inhibits methamphetamine-evoked dopamine release via inhibition of the vesicular monoamine transporter-2. J Pharmacol Exp Ther. 2010 Feb; 332(2):612-21. PMID: 19855096.
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Holtman JR, Crooks PA, Johnson-Hardy JK, Wala EP. The analgesic and toxic effects of nornicotine enantiomers alone and in interaction with morphine in rodent models of acute and persistent pain. Pharmacol Biochem Behav. 2010 Jan; 94(3):352-62. PMID: 19800911.
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Zheng F, Dwoskin LP, Crooks PA, Zhan CG. First-Principles Determination of Molecular Conformations of Indolizidine (-)-235B' in Solution. Theor Chem Acc. 2009 Oct 01; 124(3-4):269-278. PMID: 20161506.
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Struthers AM, Wilkinson JL, Dwoskin LP, Crooks PA, Bevins RA. Mecamylamine, dihydro-beta-erythroidine, and dextromethorphan block conditioned responding evoked by the conditional stimulus effects of nicotine. Pharmacol Biochem Behav. 2009 Dec; 94(2):319-28. PMID: 19778551.
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Penthala NR, Reddy TR, Parkin S, Crooks PA. 3-(2-Amino-1-methyl-4-oxo-4,5-dihydro-1H-imidazol-5-yl)-3-hydr-oxy-1-phenyl-indolin-2-one ethanol solvate. Acta Crystallogr Sect E Struct Rep Online. 2009 Sep 12; 65(Pt 10):o2439-40. PMID: 21577895.
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Zheng G, Dwoskin LP, Deaciuc AG, Crooks PA. Stereocontrolled synthesis and pharmacological evaluation of cis-2,6-diphenethyl-1-azabicyclo[2.2.2]octanes as lobelane analogues. J Org Chem. 2009 Aug 21; 74(16):6072-6. PMID: 20560567.
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Neelakantan S, Surjawan I, Karacelik H, Hicks CL, Crooks PA. Synthesis of novel isoluminol probes and their use in rapid bacterial assays. Bioorg Med Chem Lett. 2009 Oct 01; 19(19):5722-6. PMID: 19700327.
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Vaddi HK, Banks SL, Chen J, Hammell DC, Crooks PA, Stinchcomb AL. Human skin permeation of 3-O-alkyl carbamate prodrugs of naltrexone. J Pharm Sci. 2009 Aug; 98(8):2611-25. PMID: 18972573.
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Smith AM, Dhawan GK, Zhang Z, Siripurapu KB, Crooks PA, Dwoskin LP. The novel nicotinic receptor antagonist, N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide (bPiDDB), inhibits nicotine-evoked [(3)H]norepinephrine overflow from rat hippocampal slices. Biochem Pharmacol. 2009 Oct 01; 78(7):889-97. PMID: 19631612.
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Penthala NR, Reddy TR, Parkin S, Crooks PA. rac-2-(2-Amino-4-oxo-4,5-dihydro-1,3-thia-zol-5-yl)-2-hydroxy-indane-1,3-dione. Acta Crystallogr Sect E Struct Rep Online. 2009 Jul 18; 65(Pt 8):o1877. PMID: 21583571.
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Worthen DR, Bence AK, Stables JP, Crooks PA. In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity. Bioorg Med Chem Lett. 2009 Sep 01; 19(17):5012-5. PMID: 19632831.
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L?pez-Hern?ndez GY, Thinschmidt JS, Zheng G, Zhang Z, Crooks PA, Dwoskin LP, Papke RL. Selective inhibition of acetylcholine-evoked responses of alpha7 neuronal nicotinic acetylcholine receptors by novel tris- and tetrakis-azaaromatic quaternary ammonium antagonists. Mol Pharmacol. 2009 Sep; 76(3):652-66. PMID: 19556356.
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Neelakantan S, Parkin S, Crooks PA. (11R)-13-Dimethyl-ammonio-11,13-dihydro-4,5-epoxy-costunolide semifumarate. Acta Crystallogr Sect E Struct Rep Online. 2009 Jun 13; 65(Pt 7):o1569. PMID: 21582849.
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Dwoskin LP, Smith AM, Wooters TE, Zhang Z, Crooks PA, Bardo MT. Nicotinic receptor-based therapeutics and candidates for smoking cessation. Biochem Pharmacol. 2009 Oct 01; 78(7):732-43. PMID: 19523455.
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Neelakantan S, Nasim S, Guzman ML, Jordan CT, Crooks PA. Aminoparthenolides as novel anti-leukemic agents: Discovery of the NF-kappaB inhibitor, DMAPT (LC-1). Bioorg Med Chem Lett. 2009 Aug 01; 19(15):4346-9. PMID: 19505822.
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Zheng F, McConnell MJ, Zhan CG, Dwoskin LP, Crooks PA. QSAR study on maximal inhibition (Imax) of quaternary ammonium antagonists for S-(-)-nicotine-evoked dopamine release from dopaminergic nerve terminals in rat striatum. Bioorg Med Chem. 2009 Jul 01; 17(13):4477-85. PMID: 19477134.
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Geng L, Rachakonda G, Morr? DJ, Morr? DM, Crooks PA, Sonar VN, Roti JL, Rogers BE, Greco S, Ye F, Salleng KJ, Sasi S, Freeman ML, Sekhar KR. Indolyl-quinuclidinols inhibit ENOX activity and endothelial cell morphogenesis while enhancing radiation-mediated control of tumor vasculature. FASEB J. 2009 Sep; 23(9):2986-95. PMID: 19395476.
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Rutkowski M, Mann W, Derose S, Selevan D, Pascual N, Diesto J, Crooks P. Implementing KDOQI CKD definition and staging guidelines in Southern California Kaiser Permanente. Am J Kidney Dis. 2009 Mar; 53(3 Suppl 3):S86-99. PMID: 19231766.
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Culver JP, Parkin S, Crooks PA. cis-2,6-Dibenzyl-cyclo-hexa-none. Acta Crystallogr Sect E Struct Rep Online. 2009 Feb 21; 65(Pt 3):o551. PMID: 21582210.
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Penthala NR, Reddy TR, Parkin S, Crooks PA. 3-(2-Amino-1-methyl-4-oxo-4,5-dihydro-1H-imidazol-5-yl)-3-hydroxy-indolin-2-one monohydrate. Acta Crystallogr Sect E Struct Rep Online. 2009 Feb 21; 65(Pt 3):o552. PMID: 21582211.
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Kiptoo PK, Paudel KS, Hammell DC, Pinninti RR, Chen J, Crooks PA, Stinchcomb AL. Transdermal delivery of bupropion and its active metabolite, hydroxybupropion: a prodrug strategy as an alternative approach. J Pharm Sci. 2009 Feb; 98(2):583-94. PMID: 18623203.
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Sonar VN, Crooks PA. Synthesis and antitubercular activity of a series of hydrazone and nitrovinyl analogs derived from heterocyclic aldehydes. J Enzyme Inhib Med Chem. 2009 Feb; 24(1):117-24. PMID: 18629678.
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Zheng F, Zheng G, Deaciuc AG, Zhan CG, Dwoskin LP, Crooks PA. Computational neural network analysis of the affinity of N-n-alkylnicotinium salts for the alpha4beta2* nicotinic acetylcholine receptor. J Enzyme Inhib Med Chem. 2009 Feb; 24(1):157-68. PMID: 18629679.
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Dwoskin LP, Pivavarchyk M, Joyce BM, Neugebauer NM, Zheng G, Zhang Z, Bardo MT, Crooks PA. Targeting reward-relevant nicotinic receptors in the discovery of novel pharmacotherapeutic agents to treat tobacco dependence. Nebr Symp Motiv. 2009; 55:31-63. PMID: 19013938.
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Penthala NR, Reddy TR, Parkin S, Crooks PA. (Z)-Methyl 4-({3-[(2,5-dioxoimidazolidin-4-yl-idene)meth-yl]-1H-indol-1-yl}meth-yl)benzoate. Acta Crystallogr Sect E Struct Rep Online. 2008 Dec 10; 65(Pt 1):o62-3. PMID: 21581703.
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Jenkins C, Hewamana S, Gilkes A, Neelakantan S, Crooks P, Mills K, Pepper C, Burnett A. Nuclear factor-kappaB as a potential therapeutic target for the novel cytotoxic agent LC-1 in acute myeloid leukaemia. Br J Haematol. 2008 Dec; 143(5):661-71. PMID: 19036014.
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Gordon CE, Balk EM, Becker BN, Crooks PA, Jaber BL, Johnson CA, Michael MA, Pereira BJ, Uhlig K, Levin A. KDOQI US commentary on the KDIGO clinical practice guideline for the prevention, diagnosis, evaluation, and treatment of hepatitis C in CKD. Am J Kidney Dis. 2008 Nov; 52(5):811-25. PMID: 18971009.
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Vartak AP, Dwoskin LP, Crooks PA. Synthesis of symmetrical 1,5-disubstituted granatanines. Tetrahedron Lett. 2008 Oct 27; 49(44):6330-6333. PMID: 23678188.
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Rahman S, Neugebauer NM, Zhang Z, Crooks PA, Dwoskin LP, Bardo MT. The novel nicotinic receptor antagonist N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide decreases nicotine-induced dopamine metabolism in rat nucleus accumbens. Eur J Pharmacol. 2008 Dec 28; 601(1-3):103-5. PMID: 19000671.
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Penthala NR, Reddy TR, Parkin S, Crooks PA. (Z)-4-[3-(2,5-Dioxoimidazolidin-4-ylidenemeth-yl)-1H-indol-1-ylmeth-yl]benzonitrile. Acta Crystallogr Sect E Struct Rep Online. 2008 Oct 18; 64(Pt 11):o2122. PMID: 21580984.
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Malkawi AH, Al-Ghananeem AM, de Leon J, Crooks PA. Nicotine exposure can be detected in cerebrospinal fluid of active and passive smokers. J Pharm Biomed Anal. 2009 Jan 15; 49(1):129-32. PMID: 19036546.
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Zheng G, Dwoskin LP, Deaciuc AG, Crooks PA. Synthesis and evaluation of a series of homologues of lobelane at the vesicular monoamine transporter-2. Bioorg Med Chem Lett. 2008 Dec 15; 18(24):6509-12. PMID: 18976906.
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Reddy TR, Penthala NR, Parkin S, Crooks PA. (Z)-Methyl 4-[3-(3-oxoquinuclidin-2-yl-idenemeth-yl)-1H-indol-1-ylmeth-yl]benzoate. Acta Crystallogr Sect E Struct Rep Online. 2008 Oct 04; 64(Pt 11):o2050. PMID: 21580918.
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Reddy TR, Penthala NR, Parkin S, Crooks PA. (Z)-4-[3-(3-Oxoquinuclidin-2-ylidene-meth-yl)-1H-indol-1-ylmeth-yl]benzo-nitrile. Acta Crystallogr Sect E Struct Rep Online. 2008 Oct 04; 64(Pt 11):o2049. PMID: 21580917.
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Yip-Schneider MT, Wu H, Njoku V, Ralstin M, Holcomb B, Crooks PA, Neelakantan S, Sweeney CJ, Schmidt CM. Effect of celecoxib and the novel anti-cancer agent, dimethylamino-parthenolide, in a developmental model of pancreatic cancer. Pancreas. 2008 Oct; 37(3):e45-53. PMID: 18815538.
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Holtman JR, Crooks PA, Johnson-Hardy JK, Hojomat M, Kleven M, Wala EP. Effects of norketamine enantiomers in rodent models of persistent pain. Pharmacol Biochem Behav. 2008 Oct; 90(4):676-85. PMID: 18586315.
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Fernander A, Schumacher M, Wei X, Crooks P, Wedlund P. Smoking risk and the likelihood of quitting among African-American female light and heavy smokers. J Natl Med Assoc. 2008 Oct; 100(10):1199-206. PMID: 18942282.
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Holtman JR, Crooks PA, Johnson-Hardy J, Wala EP. Interaction between morphine and norketamine enantiomers in rodent models of nociception. Pharmacol Biochem Behav. 2008 Oct; 90(4):769-77. PMID: 18582492.
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Zhang Z, Zheng G, Pivavarchyk M, Deaciuc AG, Dwoskin LP, Crooks PA. Tetrakis-azaaromatic quaternary ammonium salts: novel subtype-selective antagonists at neuronal nicotinic receptors that mediate nicotine-evoked dopamine release. Bioorg Med Chem Lett. 2008 Nov 01; 18(21):5753-7. PMID: 18851914.
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Zhang Z, Lockman PR, Mittapalli RK, Allen DD, Dwoskin LP, Crooks PA. bis-Pyridinium cyclophanes: novel ligands with high affinity for the blood-brain barrier choline transporter. Bioorg Med Chem Lett. 2008 Oct 15; 18(20):5622-5. PMID: 18793853.
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Albayati ZA, Dwoskin LP, Crooks PA. Pharmacokinetics of the novel nicotinic receptor antagonist N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide in the rat. Drug Metab Dispos. 2008 Oct; 36(10):2024-9. PMID: 18617603.
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Nasim S, Crooks PA. Antileukemic activity of aminoparthenolide analogs. Bioorg Med Chem Lett. 2008 Jul 15; 18(14):3870-3. PMID: 18590961.
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Dwoskin LP, Wooters TE, Sumithran SP, Siripurapu KB, Joyce BM, Lockman PR, Manda VK, Ayers JT, Zhang Z, Deaciuc AG, McIntosh JM, Crooks PA, Bardo MT. N,N'-Alkane-diyl-bis-3-picoliniums as nicotinic receptor antagonists: inhibition of nicotine-evoked dopamine release and hyperactivity. J Pharmacol Exp Ther. 2008 Aug; 326(2):563-76. PMID: 18460644.
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Malkawi AH, Al-Ghananeem AM, Crooks PA. Development of a GC-MS assay for the determination of fentanyl pharmacokinetics in rabbit plasma after sublingual spray delivery. AAPS J. 2008 Jun; 10(2):261-7. PMID: 18459057.
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Banks SL, Pinninti RR, Gill HS, Crooks PA, Prausnitz MR, Stinchcomb AL. Flux across [corrected] microneedle-treated skin is increased by increasing charge of naltrexone and naltrexol in vitro. Pharm Res. 2008 Jul; 25(7):1677-85. PMID: 18449628.
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Papke RL, Dwoskin LP, Crooks PA, Zheng G, Zhang Z, McIntosh JM, Stokes C. Extending the analysis of nicotinic receptor antagonists with the study of alpha6 nicotinic receptor subunit chimeras. Neuropharmacology. 2008 Jun; 54(8):1189-200. PMID: 18448138.
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Bhatti BS, Strachan JP, Breining SR, Miller CH, Tahiri P, Crooks PA, Deo N, Day CS, Caldwell WS. Synthesis of 2-(pyridin-3-yl)-1-azabicyclo[3.2.2]nonane, 2-(pyridin-3-yl)-1-azabicyclo[2.2.2]octane, and 2-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, a class of potent nicotinic acetylcholine receptor-ligands. J Org Chem. 2008 May 02; 73(9):3497-507. PMID: 18363376.
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Nasim S, Parkin S, Crooks PA. (11R)-13-[2-(4-Hydroxy-phen-yl)ethyl-amino]-4,5-ep-oxy-11,13-dihydro-costunolide monohydrate. Acta Crystallogr Sect E Struct Rep Online. 2008 Feb 29; 64(Pt 3):o644. PMID: 21201974.
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Nasim S, Parkin S, Crooks PA. (11R,13R)-13-(Tetra-lin-1-ylamino)-4,5-ep-oxy-11,13-dihydro-costunolide. Acta Crystallogr Sect E Struct Rep Online. 2008 Feb 29; 64(Pt 3):o639. PMID: 21201970.
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Kiptoo PK, Paudel KS, Hammell DC, Hamad MO, Crooks PA, Stinchcomb AL. In vivo evaluation of a transdermal codrug of 6-beta-naltrexol linked to hydroxybupropion in hairless guinea pigs. Eur J Pharm Sci. 2008 Apr 23; 33(4-5):371-9. PMID: 18321686.
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Hewamana S, Alghazal S, Lin TT, Clement M, Jenkins C, Guzman ML, Jordan CT, Neelakantan S, Crooks PA, Burnett AK, Pratt G, Fegan C, Rowntree C, Brennan P, Pepper C. The NF-kappaB subunit Rel A is associated with in vitro survival and clinical disease progression in chronic lymphocytic leukemia and represents a promising therapeutic target. Blood. 2008 May 01; 111(9):4681-9. PMID: 18227347.
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Sonar VN, Parkin S, Crooks PA. 3-Ethyl-2-methyl-5-methyl-ene-6,7-di-hydroindol-4(5H)-one. Acta Crystallogr Sect E Struct Rep Online. 2007 Dec 06; 64(Pt 1):o158. PMID: 21200723.
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Sonar VN, Parkin S, Crooks PA. (Z)-3-(Benzo[b]thiophen-2-yl)-2-(3,4,5-trimethoxyphenyl)acrylonitrile and (E)-3-(benzo[b]thiophen-2-yl)-2-(3,4-dimethoxyphenyl)acrylonitrile. [corrected]. Acta Crystallogr C. 2007 Dec; 63(Pt 12):o743-5. PMID: 18057629.
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Zheng G, Sumithran SP, Deaciuc AG, Dwoskin LP, Crooks PA. Tris-azaaromatic quaternary ammonium salts: Novel templates as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release. Bioorg Med Chem Lett. 2007 Dec 15; 17(24):6701-6. PMID: 17977723.
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Zheng G, Zhang Z, Pivavarchyk M, Deaciuc AG, Dwoskin LP, Crooks PA. Bis-azaaromatic quaternary ammonium salts as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release: An investigation of binding conformation. Bioorg Med Chem Lett. 2007 Dec 15; 17(24):6734-8. PMID: 18029180.
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Sonar VN, Thirupathi Reddy Y, Sekhar KR, Sasi S, Freeman ML, Crooks PA. Novel substituted (Z)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-one and (Z)-(+/-)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-ol derivatives as potent thermal sensitizing agents. Bioorg Med Chem Lett. 2007 Dec 15; 17(24):6821-4. PMID: 17980582.
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Lockman PR, Manda VK, Geldenhuys WJ, Mittapalli RK, Thomas F, Albayati ZF, Crooks PA, Dwoskin LP, Allen DD. Carrier-mediated transport of the quaternary ammonium neuronal nicotinic receptor antagonist n,n'-dodecylbispicolinium dibromide at the blood-brain barrier. J Pharmacol Exp Ther. 2008 Jan; 324(1):244-50. PMID: 17921191.
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Guzman ML, Rossi RM, Neelakantan S, Li X, Corbett CA, Hassane DC, Becker MW, Bennett JM, Sullivan E, Lachowicz JL, Vaughan A, Sweeney CJ, Matthews W, Carroll M, Liesveld JL, Crooks PA, Jordan CT. An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells. Blood. 2007 Dec 15; 110(13):4427-35. PMID: 17804695.
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Sun Y, St Clair DK, Fang F, Warren GW, Rangnekar VM, Crooks PA, St Clair WH. The radiosensitization effect of parthenolide in prostate cancer cells is mediated by nuclear factor-kappaB inhibition and enhanced by the presence of PTEN. Mol Cancer Ther. 2007 Sep; 6(9):2477-86. PMID: 17876045.
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Vegeler RC, Yip-Schneider MT, Ralstin M, Wu H, Crooks PA, Neelakantan S, Nakshatri H, Sweeney CJ, Schmidt CM. Effect of celecoxib and novel agent LC-1 in a hamster model of lung cancer. J Surg Res. 2007 Nov; 143(1):169-76. PMID: 17950089.
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Sonar VN, Venkatraj M, Parkin S, Crooks PA. rac-(Z)-2-(2-Thienylmethylene)-1-azabicyclo[2.2.2]octan-3-ol. Acta Crystallogr C. 2007 Aug; 63(Pt 8):o493-5. PMID: 17675705.
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Dwoskin LP, Joyce BM, Zheng G, Neugebauer NM, Manda VK, Lockman P, Papke RL, Bardo MT, Crooks PA. Discovery of a novel nicotinic receptor antagonist for the treatment of nicotine addiction: 1-(3-Picolinium)-12-triethylammonium-dodecane dibromide (TMPD). Biochem Pharmacol. 2007 Oct 15; 74(8):1271-82. PMID: 17727820.
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Malkawi AH, Al-Ghananeem AM, Nasim S, de Leon J, Crooks PA. An HPLC method for the simultaneous determination of neurotoxic dipyridyl isomers in human plasma. J Pharm Biomed Anal. 2007 Sep 21; 45(1):120-124. PMID: 17706392.
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Ring JR, Parkin S, Crooks PA. (4-Methoxy-3-nitrobenzylideneamino)guanidinium chloride. Acta Crystallogr C. 2007 Jul; 63(Pt 7):o392-4. PMID: 17609569.
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Neugebauer NM, Harrod SB, Stairs DJ, Crooks PA, Dwoskin LP, Bardo MT. Lobelane decreases methamphetamine self-administration in rats. Eur J Pharmacol. 2007 Sep 24; 571(1):33-8. PMID: 17612524.
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Howard-Sparks M, Al-Ghananeem AM, Crooks PA, Pearson AP. A novel chemical delivery system comprising an ocular sustained release formulation of a 3alpha, 17alpha, 21-trihydroxy-5beta-pregnan-20-one-BIS-5-fluorouracil [correction of flourouracil] codrug. Drug Dev Ind Pharm. 2007 Jun; 33(6):677-82. PMID: 17613031.
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Yip-Schneider MT, Wu H, Ralstin M, Yiannoutsos C, Crooks PA, Neelakantan S, Noble S, Nakshatri H, Sweeney CJ, Schmidt CM. Suppression of pancreatic tumor growth by combination chemotherapy with sulindac and LC-1 is associated with cyclin D1 inhibition in vivo. Mol Cancer Ther. 2007 Jun; 6(6):1736-44. PMID: 17541034.
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Nalluri BN, Chowdary KP, Murthy KV, Becket G, Crooks PA. Tablet formulation studies on nimesulide and meloxicam-cyclodextrin binary systems. AAPS PharmSciTech. 2007 May 11; 8(2):Article 36. PMID: 17622114.
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Al-Ghananeem AM, Malkawi AH, Crooks PA. Scopolamine sublingual spray: an alternative route of delivery for the treatment of motion sickness. Drug Dev Ind Pharm. 2007 May; 33(5):577-82. PMID: 17520450.
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Sonar VN, Venkatraj M, Parkin S, Crooks PA. (Z)-2-[(1-Phenylsulfonyl-1H-indol-3-yl)methylene]-1-azabicyclo[2.2.2]octan-3-one semicarbazone. Acta Crystallogr C. 2007 May; 63(Pt 5):o277-9. PMID: 17478911.
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Al-Ghananeem AM, Crooks PA. Phase I and phase II ocular metabolic activities and the role of metabolism in ophthalmic prodrug and codrug design and delivery. Molecules. 2007 Mar 08; 12(3):373-88. PMID: 17851396.
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Middleton LS, Crooks PA, Wedlund PJ, Cass WA, Dwoskin LP. Nornicotine inhibition of dopamine transporter function in striatum via nicotinic receptor activation. Synapse. 2007 Mar; 61(3):157-65. PMID: 17146768.
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Zheng F, Zheng G, Deaciuc AG, Zhan CG, Dwoskin LP, Crooks PA. Computational neural network analysis of the affinity of lobeline and tetrabenazine analogs for the vesicular monoamine transporter-2. Bioorg Med Chem. 2007 Apr 15; 15(8):2975-92. PMID: 17331733.
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Al-Ghananeem AM, Albayati ZF, Malkawi A, Sonar VN, Freeman ML, Crooks PA. A pharmacokinetic study on Z-(+/-)-2-(1-benzylindole-3-yl-methylene)azabicyclo[2.2.2]octane-3-ol; a novel radio-sensitization agent. Cancer Chemother Pharmacol. 2007 Nov; 60(6):915-9. PMID: 17294191.
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Sonar VN, Parkin S, Crooks PA. (Z)-2-(1-Benzyl-5-nitro-1H-indol-3-ylmethylene)-1-azabicyclo[2.2.2]octan-3-one. Acta Crystallogr C. 2007 Feb; 63(Pt 2):o135-6. PMID: 17284808.
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Sekhar KR, Sonar VN, Muthusamy V, Sasi S, Laszlo A, Sawani J, Horikoshi N, Higashikubo R, Bristow RG, Borrelli MJ, Crooks PA, Lepock JR, Roti Roti JL, Freeman ML. Novel chemical enhancers of heat shock increase thermal radiosensitization through a mitotic catastrophe pathway. Cancer Res. 2007 Jan 15; 67(2):695-701. PMID: 17234780.
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Papke RL, Dwoskin LP, Crooks PA. The pharmacological activity of nicotine and nornicotine on nAChRs subtypes: relevance to nicotine dependence and drug discovery. J Neurochem. 2007 Apr; 101(1):160-7. PMID: 17241116.
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Huang X, Zheng F, Chen X, Crooks PA, Dwoskin LP, Zhan CG. Modeling subtype-selective agonists binding with alpha4beta2 and alpha7 nicotinic acetylcholine receptors: effects of local binding and long-range electrostatic interactions. J Med Chem. 2006 Dec 28; 49(26):7661-74. PMID: 17181149.
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Chen J, Deaciuc AG, Dwoskin LP, Crooks PA, Bai D. N, N -disubstituted piperazines and homopiperazines: synthesis and affinities at alpha4beta2* and alpha7* neuronal nicotinic acetylcholine receptors. J Enzyme Inhib Med Chem. 2006 Dec; 21(6):667-80. PMID: 17252939.
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Zheng G, Dwoskin LP, Crooks PA. Vesicular monoamine transporter 2: role as a novel target for drug development. AAPS J. 2006 Nov 10; 8(4):E682-92. PMID: 17233532.
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Rahman S, Neugebauer NM, Zhang Z, Crooks PA, Dwoskin LP, Bardo MT. The effects of a novel nicotinic receptor antagonist N,N-dodecane-1,12-diyl-bis-3-picolinium dibromide (bPiDDB) on acute and repeated nicotine-induced increases in extracellular dopamine in rat nucleus accumbens. Neuropharmacology. 2007 Mar; 52(3):755-63. PMID: 17097117.
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Zheng G, Horton DB, Deaciuc AG, Dwoskin LP, Crooks PA. Des-keto lobeline analogs with increased potency and selectivity at dopamine and serotonin transporters. Bioorg Med Chem Lett. 2006 Oct 01; 16(19):5018-21. PMID: 16905316.
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Hamad MO, Kiptoo PK, Stinchcomb AL, Crooks PA. Synthesis and hydrolytic behavior of two novel tripartate codrugs of naltrexone and 6beta-naltrexol with hydroxybupropion as potential alcohol abuse and smoking cessation agents. Bioorg Med Chem. 2006 Oct 15; 14(20):7051-61. PMID: 16798000.
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Crooks PA, Kottayil SG, Al-Ghananeem AM, Byrn SR, Butterfield DA. Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners. Bioorg Med Chem Lett. 2006 Aug 15; 16(16):4291-5. PMID: 16777416.
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Kiptoo PK, Hamad MO, Crooks PA, Stinchcomb AL. Enhancement of transdermal delivery of 6-beta-naltrexol via a codrug linked to hydroxybupropion. J Control Release. 2006 Jun 28; 113(2):137-45. PMID: 16750868.
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Al-Ghananeem AM, Malkawi AH, Crooks PA. Effect of pH on sublingual absorption of oxycodone hydrochloride. AAPS PharmSciTech. 2006 Mar 10; 7(1):E23. PMID: 16584154.
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Sonar VN, Parkin S, Crooks PA. 1-(1H-Indol-3-ylcarbonyl)-N-(4-methoxybenzyl)formamide. Acta Crystallogr C. 2006 Mar; 62(Pt 3):o153-4. PMID: 16518054.
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Chandrasekaran S, Al-Ghananeem AM, Riggs RM, Crooks PA. Synthesis and stability of two indomethacin prodrugs. Bioorg Med Chem Lett. 2006 Apr 01; 16(7):1874-9. PMID: 16439128.
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Zheng F, Bayram E, Sumithran SP, Ayers JT, Zhan CG, Schmitt JD, Dwoskin LP, Crooks PA. QSAR modeling of mono- and bis-quaternary ammonium salts that act as antagonists at neuronal nicotinic acetylcholine receptors mediating dopamine release. Bioorg Med Chem. 2006 May 01; 14(9):3017-37. PMID: 16431111.
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Wilkins LH, Miller DK, Ayers JT, Crooks PA, Dwoskin LP. N-n-alkylnicotinium analogs, a novel class of antagonists at alpha 4 beta 2* nicotinic acetylcholine receptors: inhibition of S(-)-nicotine-evoked 86Rb+ efflux from rat thalamic synaptosomes. AAPS J. 2006 Jan 13; 7(4):E922-30. PMID: 16594645.
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Glazer S, Diesto J, Crooks P, Yeoh H, Pascual N, Selevan D, Derose S, Farooq M. Going beyond the kidney disease outcomes quality initiative: hemodialysis access experience at Kaiser Permanente Southern California. Ann Vasc Surg. 2006 Jan; 20(1):75-82. PMID: 16378153.
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Ayers JT, Xu R, Dwoskin LP, Crooks PA. A general procedure for the enantioselective synthesis of the minor tobacco alkaloids nornicotine, anabasine, and anatabine. AAPS J. 2005 Oct 31; 7(3):E752-8. PMID: 16353951.
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Ayers JT, Clauset A, Schmitt JD, Dwoskin LP, Crooks PA. Molecular modeling of mono- and bis-quaternary ammonium salts as ligands at the alpha4beta2 nicotinic acetylcholine receptor subtype using nonlinear techniques. AAPS J. 2005 Oct 25; 7(3):E678-85. PMID: 16353944.
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Sonar VN, Parkin S, Crooks PA. (Z)-2-(3-methoxybenzylidene)-1-azabicyclo[2.2.2]octan-3-one. Acta Crystallogr C. 2005 Nov; 61(Pt 11):o660-1. PMID: 16272604.
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Huang X, Zheng F, Crooks PA, Dwoskin LP, Zhan CG. Modeling multiple species of nicotine and deschloroepibatidine interacting with alpha4beta2 nicotinic acetylcholine receptor: from microscopic binding to phenomenological binding affinity. J Am Chem Soc. 2005 Oct 19; 127(41):14401-14. PMID: 16218635.
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Zheng G, Dwoskin LP, Deaciuc AG, Crooks PA. Synthesis and evaluation of a series of tropane analogues as novel vesicular monoamine transporter-2 ligands. Bioorg Med Chem Lett. 2005 Oct 15; 15(20):4463-6. PMID: 16112864.
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Howard-Sparks M, Al-Ghananeem AM, Pearson AP, Crooks PA. Evaluation of O(3alpha)-, O(21)-di-(N(1)-methyloxycarbonyl-2, 4-dioxo-5-fluoropyrimidinyl) 17alpha-hydroxy-5beta-pregnan-20-one as a novel potential antiangiogenic codrug. J Enzyme Inhib Med Chem. 2005 Oct; 20(5):417-28. PMID: 16335049.
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Nalluri BN, Milligan C, Chen J, Crooks PA, Stinchcomb AL. In vitro release studies on matrix type transdermal drug delivery systems of naltrexone and its acetyl prodrug. Drug Dev Ind Pharm. 2005 Oct; 31(9):871-7. PMID: 16305998.
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Wei X, Sumithran SP, Deaciuc AG, Burton HR, Bush LP, Dwoskin LP, Crooks PA. Identification and synthesis of novel alkaloids from the root system of Nicotiana tabacum: affinity for neuronal nicotinic acetylcholine receptors. Life Sci. 2005 Dec 22; 78(5):495-505. PMID: 16197964.
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Papke RL, Zheng G, Horenstein NA, Dwoskin LP, Crooks PA. The characterization of a novel rigid nicotine analog with alpha7-selective nAChR agonist activity and modulation of agonist properties by boron inclusion. Bioorg Med Chem Lett. 2005 Sep 01; 15(17):3874-80. PMID: 16005216.
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Paudel KS, Nalluri BN, Hammell DC, Valiveti S, Kiptoo P, Hamad MO, Crooks PA, Stinchcomb AL. Transdermal delivery of naltrexone and its active metabolite 6-beta-naltrexol in human skin in vitro and guinea pigs in vivo. J Pharm Sci. 2005 Sep; 94(9):1965-75. PMID: 16052561.
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Sumithran SP, Crooks PA, Xu R, Zhu J, Deaciuc AG, Wilkins LH, Dwoskin LP. Introduction of unsaturation into the N-n-alkyl chain of the nicotinic receptor antagonists, NONI and NDNI: effect on affinity and selectivity. AAPS J. 2005 Aug 29; 7(1):E201-17. PMID: 16146341.
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Zheng G, Dwoskin LP, Deaciuc AG, Norrholm SD, Crooks PA. Defunctionalized lobeline analogues: structure-activity of novel ligands for the vesicular monoamine transporter. J Med Chem. 2005 Aug 25; 48(17):5551-60. PMID: 16107155.
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Cynkowska G, Cynkowski T, Al-Ghananeem AM, Al-Ghananeem AA, Guo H, Ashton P, Crooks PA. Novel antiglaucoma prodrugs and codrugs of ethacrynic acid. Bioorg Med Chem Lett. 2005 Aug 01; 15(15):3524-7. PMID: 15990301.
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Sonar VN, Parkin S, Crooks PA. (E)-2-Methyl-3-(2-methyl-2-nitrovinyl)-1H-indole and (E)-3-(2-methyl-2-nitrovinyl)-2-phenyl-1H-indole. Acta Crystallogr C. 2005 Aug; 61(Pt 8):o527-30. PMID: 16082109.
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Geldenhuys WJ, Lockman PR, Nguyen TH, Van der Schyf CJ, Crooks PA, Dwoskin LP, Allen DD. 3D-QSAR study of bis-azaaromatic quaternary ammonium analogs at the blood-brain barrier choline transporter. Bioorg Med Chem. 2005 Jul 01; 13(13):4253-61. PMID: 15878282.
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Valiveti S, Paudel KS, Hammell DC, Hamad MO, Chen J, Crooks PA, Stinchcomb AL. In vitro/in vivo correlation of transdermal naltrexone prodrugs in hairless guinea pigs. Pharm Res. 2005 Jun; 22(6):981-9. PMID: 15948042.
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Zheng G, Dwoskin LP, Deaciuc AG, Zhu J, Jones MD, Crooks PA. Lobelane analogues as novel ligands for the vesicular monoamine transporter-2. Bioorg Med Chem. 2005 Jun 02; 13(12):3899-909. PMID: 15911306.
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Vaddi HK, Hamad MO, Chen J, Banks SL, Crooks PA, Stinchcomb AL. Human skin permeation of branched-chain 3-0-alkyl ester and carbonate prodrugs of naltrexone. Pharm Res. 2005 May; 22(5):758-65. PMID: 15906171.
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Hammell DC, Stolarczyk EI, Klausner M, Hamad MO, Crooks PA, Stinchcomb AL. Bioconversion of naltrexone and its 3-O-alkyl-ester prodrugs in a human skin equivalent. J Pharm Sci. 2005 Apr; 94(4):828-36. PMID: 15736197.
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Valiveti S, Hammell DC, Paudel KS, Hamad MO, Crooks PA, Stinchcomb AL. In vivo evaluation of 3-O-alkyl ester transdermal prodrugs of naltrexone in hairless guinea pigs. J Control Release. 2005 Feb 02; 102(2):509-20. PMID: 15653167.
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Sonar VN, Parkin S, Crooks PA. (Z)-3-(1H-Indol-3-yl)-2-(3-thienyl)acrylonitrile and (Z)-3-[1-(4-tert-butylbenzyl)-1H-indol-3-yl]-2-(3-thienyl)acrylonitrile. Acta Crystallogr C. 2005 Feb; 61(Pt 2):o78-80. PMID: 15695916.
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Crooks P. Managing high-risk, high-cost patients: the southern california kaiser permanente experience in the medicare ESRD demonstration project. Perm J. 2005; 9(2):93-7. PMID: 21660174.
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Zheng G, Dwoskin LP, Crooks PA. Indirect trapping of the retroconjugate addition reaction intermediate involved in the epimerization of lobeline: application to the synthesis of (-)-sedamine. J Org Chem. 2004 Nov 26; 69(24):8514-7. PMID: 15549833.
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Li S, Crooks PA, Wei X, de Leon J. Toxicity of dipyridyl compounds and related compounds. Crit Rev Toxicol. 2004 Sep-Oct; 34(5):447-60. PMID: 15560568.
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Sonar VN, Parkin S, Crooks PA. (Z)-2-(1-Phenylsulfonyl-1H-indol-3-ylmethylene)-1-azabicyclo[2.2.2]octan-3-one and (Z)-(S)-2-(1-phenylsulfonyl-1H-indol-3-ylmethylene)-1-azabicyclo[2.2.2]octan-3-ol. Acta Crystallogr C. 2004 Sep; 60(Pt 9):o659-61. PMID: 15345848.
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Sonar VN, Parkin S, Crooks PA. 1-(2,5-Dichlorophenyl)-3-methyl-5-phenyl-1H-pyrazole. Acta Crystallogr C. 2004 Aug; 60(Pt 8):o547-9. PMID: 15295183.
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Sonar VN, Parkin S, Crooks PA. (E)-N-[(Benzo[b]thiophen-3-yl)methylene]-N'-(2,5-dichlorophenyl)hydrazine. Acta Crystallogr C. 2004 Aug; 60(Pt 8):o550-1. PMID: 15295184.
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Pillai O, Hamad MO, Crooks PA, Stinchcomb AL. Physicochemical evaluation, in vitro human skin diffusion, and concurrent biotransformation of 3-O-alkyl carbonate prodrugs of naltrexone. Pharm Res. 2004 Jul; 21(7):1146-52. PMID: 15290853.
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Hammell DC, Hamad M, Vaddi HK, Crooks PA, Stinchcomb AL. A duplex "Gemini" prodrug of naltrexone for transdermal delivery. J Control Release. 2004 Jun 18; 97(2):283-90. PMID: 15196755.
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Miller DK, Crooks PA, Zheng G, Grinevich VP, Norrholm SD, Dwoskin LP. Lobeline analogs with enhanced affinity and selectivity for plasmalemma and vesicular monoamine transporters. J Pharmacol Exp Ther. 2004 Sep; 310(3):1035-45. PMID: 15121762.
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Crooks PA, Ayers JT, Xu R, Sumithran SP, Grinevich VP, Wilkins LH, Deaciuc AG, Allen DD, Dwoskin LP. Development of subtype-selective ligands as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release. Bioorg Med Chem Lett. 2004 Apr 19; 14(8):1869-74. PMID: 15050618.
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Dwoskin LP, Sumithran SP, Zhu J, Deaciuc AG, Ayers JT, Crooks PA. Subtype-selective nicotinic receptor antagonists: potential as tobacco use cessation agents. Bioorg Med Chem Lett. 2004 Apr 19; 14(8):1863-7. PMID: 15050617.
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Gali-Muhtasib HU, Abou Kheir WG, Kheir LA, Darwiche N, Crooks PA. Molecular pathway for thymoquinone-induced cell-cycle arrest and apoptosis in neoplastic keratinocytes. Anticancer Drugs. 2004 Apr; 15(4):389-99. PMID: 15057144.
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Ko K, Wei X, Crooks PA, Koprowski H. Elimination of alkaloids from plant-derived human monoclonal antibody. J Immunol Methods. 2004 Mar; 286(1-2):79-85. PMID: 15087223.
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Sonar VN, Parkin S, Crooks PA. (Z)-3-(1-Methyl-1H-indol-3-yl)-2-(thiophen-3-yl)acrylonitrile. Acta Crystallogr C. 2004 Mar; 60(Pt 3):o217-8. PMID: 15004388.
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Crooks P. International care models for chronic kidney disease: methods and economics--United States. Blood Purif. 2004; 22(1):13-20. PMID: 14732807.
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Balbo PB, Patel CN, Sell KG, Adcock RS, Neelakantan S, Crooks PA, Oliveira MA. Spectrophotometric and steady-state kinetic analysis of the biosynthetic arginine decarboxylase of Yersinia pestis utilizing arginine analogues as inhibitors and alternative substrates. Biochemistry. 2003 Dec 30; 42(51):15189-96. PMID: 14690429.
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Sonar VN, Parkin S, Crooks PA. (Z)-2-(1H-Indol-3-ylmethylene)-1-azabicyclo[2.2.2]octan-3-one. Acta Crystallogr C. 2004 Jan; 60(Pt 1):o6-8. PMID: 14712032.
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Zheng G, Parkin S, Dwoskin LP, Crooks PA. Two isomers of 2,4-dibenzyl-8-azabicyclo[3.2.1]octan-3-ol. Acta Crystallogr C. 2004 Jan; 60(Pt 1):o9-11. PMID: 14712033.
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Sonar VN, Parkin S, Crooks PA. (Z)-2-(3-hydroxy-4-methoxybenzylidene)-1-azabicyclo[2.2.2]octan-3-one. Acta Crystallogr C. 2003 Nov; 59(Pt 11):o647-9. PMID: 14605418.
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Bence AK, Crooks PA. The mechanism of L-canavanine cytotoxicity: arginyl tRNA synthetase as a novel target for anticancer drug discovery. J Enzyme Inhib Med Chem. 2003 Oct; 18(5):383-94. PMID: 14692504.
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Crooks P. The first ESRD managed care demonstration project: a Kaiser Permanente view. Nephrol News Issues. 2003 Oct; 17(11):29-31, 34-5. PMID: 14593817.
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Sekhar KR, Crooks PA, Sonar VN, Friedman DB, Chan JY, Meredith MJ, Starnes JH, Kelton KR, Summar SR, Sasi S, Freeman ML. NADPH oxidase activity is essential for Keap1/Nrf2-mediated induction of GCLC in response to 2-indol-3-yl-methylenequinuclidin-3-ols. Cancer Res. 2003 Sep 01; 63(17):5636-45. PMID: 14500406.
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Yeoh HH, Rasgon S, Rutkowski M, Crooks P, Idroos M, Diesto J. Management of patients with chronic kidney disease at Kaiser Permanente. Nephrol News Issues. 2003 Aug; 17(9):25-7, 30. PMID: 12971222.
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Grinevich VP, Crooks PA, Sumithran SP, Haubner AJ, Ayers JT, Dwoskin LP. N-n-alkylpyridinium analogs, a novel class of nicotinic receptor antagonists: selective inhibition of nicotine-evoked [3H] dopamine overflow from superfused rat striatal slices. J Pharmacol Exp Ther. 2003 Sep; 306(3):1011-20. PMID: 12766255.
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de Leon J, Diaz FJ, Rogers T, Browne D, Dinsmore L, Ghosheh OA, Dwoskin LP, Crooks PA. Plasma cotinine, 3'-hydroxycotinine, and their glucuronides in white and black smokers. J Clin Psychopharmacol. 2003 Apr; 23(2):209-11. PMID: 12640226.
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Allen DD, Lockman PR, Roder KE, Dwoskin LP, Crooks PA. Active transport of high-affinity choline and nicotine analogs into the central nervous system by the blood-brain barrier choline transporter. J Pharmacol Exp Ther. 2003 Mar; 304(3):1268-74. PMID: 12604705.
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Bence AK, Adams VR, Crooks PA. L-Canavanine as a radiosensitization agent for human pancreatic cancer cells. Mol Cell Biochem. 2003 Feb; 244(1-2):37-43. PMID: 12701807.
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de Leon J, Diaz FJ, Rogers T, Browne D, Dinsmore L, Ghosheh OH, Dwoskin LP, Crooks PA. A pilot study of plasma caffeine concentrations in a US sample of smoker and nonsmoker volunteers. Prog Neuropsychopharmacol Biol Psychiatry. 2003 Feb; 27(1):165-71. PMID: 12551740.
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Bence AK, Worthen DR, Stables JP, Crooks PA. An in vivo evaluation of the antiseizure activity and acute neurotoxicity of agmatine. Pharmacol Biochem Behav. 2003 Feb; 74(3):771-5. PMID: 12543244.
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Chen J, Norrholm S, Dwoskin LP, Crooks PA, Bai D. N,N-disubstituted piperazines: synthesis and affinities at alpha4beta2(*) and alpha7(*) neuronal nicotinic acetylcholine receptors. Bioorg Med Chem Lett. 2003 Jan 06; 13(1):97-100. PMID: 12467625.
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Wilkins LH, Grinevich VP, Ayers JT, Crooks PA, Dwoskin LP. N-n-alkylnicotinium analogs, a novel class of nicotinic receptor antagonists: interaction with alpha4beta2* and alpha7* neuronal nicotinic receptors. J Pharmacol Exp Ther. 2003 Jan; 304(1):400-10. PMID: 12490617.
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Ayers JT, Dwoskin LP, Deaciuc AG, Grinevich VP, Zhu J, Crooks PA. bis-Azaaromatic quaternary ammonium analogues: ligands for alpha4beta2* and alpha7* subtypes of neuronal nicotinic receptors. Bioorg Med Chem Lett. 2002 Nov 04; 12(21):3067-71. PMID: 12372503.
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Ring JR, Haubner AJ, Crooks PA. Novel antiepileptic and anticonvulsive therapeutic agents. IDrugs. 2002 Oct; 5(10):990-9. PMID: 12800062.
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de Leon J, Diaz FJ, Rogers T, Browne D, Dinsmore L, Ghosheh OH, Dwoskin LP, Crooks PA. Total cotinine in plasma: a stable biomarker for exposure to tobacco smoke. J Clin Psychopharmacol. 2002 Oct; 22(5):496-501. PMID: 12352273.
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Wilkins LH, Haubner A, Ayers JT, Crooks PA, Dwoskin LP. N-n-alkylnicotinium analogs, a novel class of nicotinic receptor antagonist: inhibition of S(-)-nicotine-evoked [(3)H]dopamine overflow from superfused rat striatal slices. J Pharmacol Exp Ther. 2002 Jun; 301(3):1088-96. PMID: 12023541.
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Bence AK, Worthen DR, Adams VR, Crooks PA. The antiproliferative and immunotoxic effects of L-canavanine and L-canaline. Anticancer Drugs. 2002 Mar; 13(3):313-20. PMID: 11984075.
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Dwoskin LP, Crooks PA. A novel mechanism of action and potential use for lobeline as a treatment for psychostimulant abuse. Biochem Pharmacol. 2002 Jan 15; 63(2):89-98. PMID: 11841781.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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Year | Publications |
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2002 | 6 | 2003 | 16 | 2004 | 14 | 2005 | 22 | 2006 | 14 | 2007 | 26 | 2008 | 27 | 2009 | 32 | 2010 | 24 | 2011 | 21 | 2012 | 13 | 2013 | 24 | 2014 | 20 | 2015 | 16 | 2016 | 16 | 2017 | 11 | 2018 | 16 | 2019 | 5 | 2020 | 9 | 2021 | 8 | 2022 | 1 | 2023 | 3 | 2024 | 1 |
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