Header Logo
Keywords
Last Name
Institution
Announcement

You can now add alternative names! Click here to add other names that you've published under.

Peter Crooks

TitleDepartment Chairperson
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentCollege of Pharmacy, College of Provost
DivisionPharmaceutical Science
Address140-2D Biomedical Research II
200 South Cedar
Mail Slot # 622
Little Rock AR 72202
Phone501-686-6495
vCardDownload vCard

    Collapse Research Funds 
    Collapse principal investigator/co-principal investigator research activities
    R21DA049585     (BRENTS, LISA KAYE)Aug 1, 2019 - Jul 31, 2021
    NIH/NIDA
    Use of precision deuteration to determine the contribution of norbuprenorphine to buprenorphine-associated neonatal abstinence syndrome
    Role: Co-Investigator

    U01DA043908     (CROOKS, PETER)Aug 1, 2018 - Jul 31, 2019
    NIH/Nat. Inst. on Drug Abuse - Pass Through: University of Kentucky Research Foundation
    Development of Novel Therapeutics for Methamphetamine Abuse
    Role: Principal Investigator

    W81XWH-15-1-0716     (SMELTZER, MARK)Sep 30, 2015 - Sep 29, 2019
    US Department of Defense
    Enhancing the prevention and treatment of orthopaedic infections associated with traumatic injury
    Role: Co-Investigator

    OIA-145788     (GRIFFIN, ROBERT)Sep 18, 2015 - Jul 31, 2020
    National Science Foundation - Pass Through: Arkansas Science & Technology Authority
    RII Track-1: Arkansas ASSET Initiative III
    Role: Co-Investigator

    OIA-1457888     (GRIFFIN, ROBERT)Sep 18, 2015 - Jul 31, 2020
    National Science Foundation - Pass Through: Arkansas Science & Technology Authority
    RII Track-1: Arkansas ASSET Initiative III
    Role: Co-Investigator

    16-EPS3-0013     (GRIFFIN, ROBERT)Sep 18, 2015 - Sep 30, 2019
    National Science Foundation - Pass Through: Arkansas Science & Technology Authority
    RII Track-1: Arkansas ASSET Initiative III
    Role: Co-Investigator

    P20GM109005     (HAUER-JENSEN, MARTIN)Jun 24, 2015 - Mar 31, 2020
    NIH/NIGMS
    Center for Studies of Host Response to Cancer Therapy
    Role: Co-Investigator

    U01DA013519     (CROOKS, PETER)Jul 1, 2014 - Jun 30, 2018
    NIH/Nat. Inst. on Drug Abuse - Pass Through: University of Kentucky Research Foundation
    Development of Novel Therapies for Methamphetamine Abuse
    Role: Principal Investigator

    R01CA140409     (CROOKS, PETER)Dec 1, 2011 - Dec 30, 2014
    NIH/Nat. Cancer Institute - Pass Through: Vanderbilt University
    Development of Small Molecule Radiation Sensitizers
    Role: Principal Investigator

    R01CA158275     (CROOKS, PETER ANTHONY)Jul 1, 2011 - May 31, 2016
    NIH/NCI
    Novel melampomagnolide B-based prodrugs for the treatment of leukemia
    Role: Principal Investigator

    R56DK076735     (DRANOFF, JONATHAN A)Dec 1, 2006 - Aug 31, 2016
    NIH/NIDDK
    Regulation of hepatic stellate cells by intracellular calcium
    Role: Co-Investigator

    P01AG012411     (GRIFFIN, SUE TILTON)Jun 1, 1995 - May 31, 2021
    NIH/NIA
    Early Events in Alzheimer Pathogenesis
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
    List All   |   Timeline
    1. Balasubramaniam M, Ayyadevara S, Ganne A, Kakraba S, Penthala NR, Du X, Crooks PA, Griffin ST, Shmookler Reis RJ. Aggregate Interactome Based on Protein Cross-linking Interfaces Predicts Drug Targets to Limit Aggregation in Neurodegenerative Diseases. iScience. 2019 Oct 25; 20:248-264. PMID: 31593839.
      View in: PubMed
    2. Lee NR, Zheng G, Leggas M, Janganati V, Nickell JR, Crooks PA, Bardo MT, Dwoskin LP. GZ-11608, a Vesicular Monoamine Transporter-2 Inhibitor, Decreases the Neurochemical and Behavioral Effects of Methamphetamine. J Pharmacol Exp Ther. 2019 Nov; 371(2):526-543. PMID: 31413138.
      View in: PubMed
    3. Ketkar A, Maddukuri L, Penthala NR, Reed MR, Zafar MK, Crooks PA, Eoff RL. Inhibition of Human DNA Polymerases Eta and Kappa by Indole-Derived Molecules Occurs through Distinct Mechanisms. ACS Chem Biol. 2019 Jun 21; 14(6):1337-1351. PMID: 31082191.
      View in: PubMed
    4. Ford BM, Cabanlong CV, Tai S, Franks LN, Penthala NR, Crooks PA, Prather PL, Fantegrossi WE. Reduced Tolerance and Asymmetrical Crosstolerance to Effects of the Indole Quinuclidinone Analog PNR-4-20, a G Protein-Biased Cannabinoid 1 Receptor Agonist in Mice: Comparisons with ?9-Tetrahydrocannabinol and JWH-018. J Pharmacol Exp Ther. 2019 May; 369(2):259-269. PMID: 30833484.
      View in: PubMed
    5. Marecki JC, Aarattuthodiyil S, Byrd AK, Penthala NR, Crooks PA, Raney KD. N-Naphthoyl-substituted indole thio-barbituric acid analogs inhibit the helicase activity of the hepatitis C virus NS3. Bioorg Med Chem Lett. 2019 02 01; 29(3):430-434. PMID: 30578035.
      View in: PubMed
    6. Kearney SE, Zahoránszky-Kohalmi G, Brimacombe KR, Henderson MJ, Lynch C, Zhao T, Wan KK, Itkin Z, Dillon C, Shen M, Cheff DM, Lee TD, Bougie D, Cheng K, Coussens NP, Dorjsuren D, Eastman RT, Huang R, Iannotti MJ, Karavadhi S, Klumpp-Thomas C, Roth JS, Sakamuru S, Sun W, Titus SA, Yasgar A, Zhang YQ, Zhao J, Andrade RB, Brown MK, Burns NZ, Cha JK, Mevers EE, Clardy J, Clement JA, Crooks PA, Cuny GD, Ganor J, Moreno J, Morrill LA, Picazo E, Susick RB, Garg NK, Goess BC, Grossman RB, Hughes CC, Johnston JN, Joullie MM, Kinghorn AD, Kingston DGI, Krische MJ, Kwon O, Maimone TJ, Majumdar S, Maloney KN, Mohamed E, Murphy BT, Nagorny P, Olson DE, Overman LE, Brown LE, Snyder JK, Porco JA, Rivas F, Ross SA, Sarpong R, Sharma I, Shaw JT, Xu Z, Shen B, Shi W, Stephenson CRJ, Verano AL, Tan DS, Tang Y, Taylor RE, Thomson RJ, Vosburg DA, Wu J, Wuest WM, Zakarian A, Zhang Y, Ren T, Zuo Z, Inglese J, Michael S, Simeonov A, Zheng W, Shinn P, Jadhav A, Boxer MB, Hall MD, Xia M, Guha R, Rohde JM. Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. ACS Cent Sci. 2018 Dec 26; 4(12):1727-1741. PMID: 30648156.
      View in: PubMed
    7. Bommagani S, Penthala NR, Balasubramaniam M, Kuravi S, Caldas-Lopes E, Guzman ML, Balusu R, Crooks PA. A novel tetrazole analogue of resveratrol is a potent anticancer agent. Bioorg Med Chem Lett. 2019 01 15; 29(2):172-178. PMID: 30528695.
      View in: PubMed
    8. Maggio SE, Saunders MA, Nixon K, Prendergast MA, Zheng G, Crooks PA, Dwoskin LP, Bell RL, Bardo MT. An improved model of ethanol and nicotine co-use in female P rats: Effects of naltrexone, varenicline, and the selective nicotinic a6ß2* antagonist r-bPiDI. Drug Alcohol Depend. 2018 12 01; 193:154-161. PMID: 30384323.
      View in: PubMed
    9. Bommagani S, Penthala NR, Parkin S, Crooks PA. Crystal structure of 13-(E)-(2-amino-benzyl-idene)parthenolide. Acta Crystallogr E Crystallogr Commun. 2018 Nov 01; 74(Pt 11):1543-1546. PMID: 30443377.
      View in: PubMed
    10. Lamture G, Crooks PA, Borrelli MJ. Actinomycin-D and dimethylamino-parthenolide synergism in treating human pancreatic cancer cells. Drug Dev Res. 2018 09; 79(6):287-294. PMID: 30295945.
      View in: PubMed
    11. Dachavaram SS, Penthala NR, Calahan JL, Munson EJ, Crooks PA. Highly sulphated cellulose: a versatile, reusable and selective desilylating agent for deprotection of alcoholic TBDMS ethers. Org Biomol Chem. 2018 08 22; 16(33):6057-6062. PMID: 30090907.
      View in: PubMed
    12. Janganati V, Ponder J, Balasubramaniam M, Bhat-Nakshatri P, Bar EE, Nakshatri H, Jordan CT, Crooks PA. MMB triazole analogs are potent NF-?B inhibitors and anti-cancer agents against both hematological and solid tumor cells. Eur J Med Chem. 2018 Sep 05; 157:562-581. PMID: 30121494.
      View in: PubMed
    13. Flores-Lopez G, Moreno-Lorenzana D, Ayala-Sanchez M, Aviles-Vazquez S, Torres-Martinez H, Crooks PA, Guzman ML, Mayani H, Chávez-González A. Parthenolide and DMAPT induce cell death in primitive CML cells through reactive oxygen species. J Cell Mol Med. 2018 10; 22(10):4899-4912. PMID: 30079458.
      View in: PubMed
    14. Yadlapalli JSK, Bommagani SB, Mahelona RD, Wan A, Gannon BM, Penthala NR, Dobretsov M, Crooks PA, Fantegrossi WE. Evaluation of morphine-like effects of the mixed mu/delta agonist morphine-6-O-sulfate in rats: Drug discrimination and physical dependence. Pharmacol Res Perspect. 2018 07; 6(4):e00403. PMID: 29930811.
      View in: PubMed
    15. Yadlapalli JSK, Dogra N, Walbaum AW, Prather PL, Crooks PA, Dobretsov M. Pinprick hypo- and hyperalgesia in diabetic rats: Can diet content affect experimental outcome? Neurosci Lett. 2018 04 23; 673:24-27. PMID: 29490230.
      View in: PubMed
    16. Maggio SE, Saunders MA, Baxter TA, Nixon K, Prendergast MA, Zheng G, Crooks P, Dwoskin LP, Slack RD, Newman AH, Bell RL, Bardo MT. Effects of the nicotinic agonist varenicline, nicotinic antagonist r-bPiDI, and DAT inhibitor (R)-modafinil on co-use of ethanol and nicotine in female P rats. Psychopharmacology (Berl). 2018 05; 235(5):1439-1453. PMID: 29455292.
      View in: PubMed
    17. Lee NR, Zheng G, Crooks PA, Bardo MT, Dwoskin LP. New Scaffold for Lead Compounds to Treat Methamphetamine Use Disorders. AAPS J. 2018 02 09; 20(2):29. PMID: 29427069.
      View in: PubMed
    18. Kangiser MM, Dwoskin LP, Zheng G, Crooks PA, Stairs DJ. Varenicline and GZ-793A differentially decrease methamphetamine self-administration under a multiple schedule of reinforcement in rats. Behav Pharmacol. 2018 02; 29(1):87-97. PMID: 28863003.
      View in: PubMed
    19. Zafar MK, Maddukuri L, Ketkar A, Penthala NR, Reed MR, Eddy S, Crooks PA, Eoff RL. A Small-Molecule Inhibitor of Human DNA Polymerase ? Potentiates the Effects of Cisplatin in Tumor Cells. Biochemistry. 2018 02 20; 57(7):1262-1273. PMID: 29345908.
      View in: PubMed
    20. Madadi NR, Penthala NR, Ketkar A, Eoff RL, Trujullo-Alonso V, Guzman ML, Crooks PA. Synthesis and Evaluation of 2-Naphthaleno trans-Stilbenes and Cyanostilbenes as Anticancer Agents. Anticancer Agents Med Chem. 2018; 18(4):556-564. PMID: 28403783.
      View in: PubMed
    21. Yadlapalli JSK, Dogra N, Walbaum AW, Prather PL, Crooks PA, Dobretsov M. Preclinical assessment of utility of M6S for multimodal acute and chronic pain treatment in diabetic neuropathy. Life Sci. 2018 Jan 01; 192:151-159. PMID: 29191644.
      View in: PubMed
    22. Hankosky ER, Joolakanti SR, Nickell JR, Janganati V, Dwoskin LP, Crooks PA. Fluoroethoxy-1,4-diphenethylpiperidine and piperazine derivatives: Potent and selective inhibitors of [3H]dopamine uptake at the vesicular monoamine transporter-2. Bioorg Med Chem Lett. 2017 12 15; 27(24):5467-5472. PMID: 29153425.
      View in: PubMed
    23. Wang R, Bhat-Nakshatri P, Padua MB, Prasad MS, Anjanappa M, Jacobson M, Finnearty C, Sefcsik V, McElyea K, Redmond R, Sandusky G, Penthala N, Crooks PA, Liu J, Zimmers T, Nakshatri H. Pharmacological Dual Inhibition of Tumor and Tumor-Induced Functional Limitations in a Transgenic Model of Breast Cancer. Mol Cancer Ther. 2017 Dec; 16(12):2747-2758. PMID: 28978719.
      View in: PubMed
    24. Yadlapalli JSK, Dogra N, Walbaum AW, Wessinger WD, Prather PL, Crooks PA, Dobretsov M. Evaluation of Analgesia, Tolerance, and the Mechanism of Action of Morphine-6-O-Sulfate Across Multiple Pain Modalities in Sprague-Dawley Rats. Anesth Analg. 2017 09; 125(3):1021-1031. PMID: 28489639.
      View in: PubMed
    25. Ford BM, Franks LN, Tai S, Fantegrossi WE, Stahl EL, Berquist MD, Cabanlong CV, Wilson CD, Penthala NR, Crooks PA, Prather PL. Characterization of structurally novel G protein biased CB1 agonists: Implications for drug development. Pharmacol Res. 2017 Nov; 125(Pt B):161-177. PMID: 28838808.
      View in: PubMed
    26. Mendonca MS, Turchan WT, Alpuche ME, Watson CN, Estabrook NC, Chin-Sinex H, Shapiro JB, Imasuen-Williams IE, Rangel G, Gilley DP, Huda N, Crooks PA, Shapiro RH. DMAPT inhibits NF-?B activity and increases sensitivity of prostate cancer cells to X-rays in vitro and in tumor xenografts in vivo. Free Radic Biol Med. 2017 11; 112:318-326. PMID: 28782644.
      View in: PubMed
    27. Walbaum A, Fifer EK, Parkin S, Crooks PA. Crystal structure of 4,4'-bis-[3-(piperidin-1-yl)prop-1-yn-1-yl]-1,1'-biphen-yl. Acta Crystallogr E Crystallogr Commun. 2017 Jun 01; 73(Pt 6):864-866. PMID: 28638646.
      View in: PubMed
    28. Bommagani S, Ponder J, Penthala NR, Janganati V, Jordan CT, Borrelli MJ, Crooks PA. Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells. Eur J Med Chem. 2017 Aug 18; 136:393-405. PMID: 28525840.
      View in: PubMed
    29. Janganati V, Ponder J, Thakkar S, Jordan CT, Crooks PA. Succinamide derivatives of melampomagnolide B and their anti-cancer activities. Bioorg Med Chem. 2017 07 15; 25(14):3694-3705. PMID: 28545815.
      View in: PubMed
    30. Yadlapalli JSK, Albayati ZAF, Penthala NR, Hendrickson HP, Crooks PA. Stability studies of potent opioid analgesic, morphine-6-O-sulfate in various buffers and biological matrices by HPLC-DAD analysis. Biomed Chromatogr. 2017 Sep; 31(9). PMID: 28205234.
      View in: PubMed
    31. Al-Ghananeem AM, Malkawi AH, Crooks PA. Effect of pH on sublingual absorption of oxycodone hydrochloride. AAPS PharmSciTech. 2006 Mar; 7(1):E163-E167. PMID: 28290038.
      View in: PubMed
    32. Albayati ZAF, Janganati V, Chen Z, Ponder J, Breen PJ, Jordan CT, Crooks PA. Identification of a melampomagnolide B analog as a potential lead molecule for treatment of acute myelogenous leukemia. Bioorg Med Chem. 2017 02 01; 25(3):1235-1241. PMID: 28049618.
      View in: PubMed
    33. Nickell JR, Siripurapu KB, Horton DB, Zheng G, Crooks PA, Dwoskin LP. GZ-793A inhibits the neurochemical effects of methamphetamine via a selective interaction with the vesicular monoamine transporter-2. Eur J Pharmacol. 2017 Jan 15; 795:143-149. PMID: 27986625.
      View in: PubMed
    34. Pei S, Minhajuddin M, D'Alessandro A, Nemkov T, Stevens BM, Adane B, Khan N, Hagen FK, Yadav VK, De S, Ashton JM, Hansen KC, Gutman JA, Pollyea DA, Crooks PA, Smith C, Jordan CT. Rational design of a parthenolide-based drug regimen that selectively eradicates acute myelogenous leukemia stem cells. J Biol Chem. 2016 11 25; 291(48):25280. PMID: 27888238.
      View in: PubMed
    35. Smith CA, Mont S, Traver G, Sekhar KR, Crooks PA, Freeman ML. Targeting Enox1 in tumor stroma increases the efficacy of fractionated radiotherapy. Oncotarget. 2016 Nov 22; 7(47):77926-77936. PMID: 27788492.
      View in: PubMed
    36. Penthala NR, Janganati V, Alpe TL, Apana SM, Berridge MS, Crooks PA, Borrelli MJ. N-[11CH3]Dimethylaminoparthenolide (DMAPT) uptake into orthotopic 9LSF glioblastoma tumors in the rat. Bioorg Med Chem Lett. 2016 12 15; 26(24):5883-5886. PMID: 27866815.
      View in: PubMed
    37. Yadlapalli JSK, Ford BM, Ketkar A, Wan A, Penthala NR, Eoff RL, Prather PL, Dobretsov M, Crooks PA. Antinociceptive effects of the 6-O-sulfate ester of morphine in normal and diabetic rats: Comparative role of mu- and delta-opioid receptors. Pharmacol Res. 2016 11; 113(Pt A):335-347. PMID: 27637375.
      View in: PubMed
    38. Pei S, Minhajuddin M, D'Alessandro A, Nemkov T, Stevens BM, Adane B, Khan N, Hagen FK, Yadav VK, De S, Ashton JM, Hansen KC, Gutman JA, Pollyea DA, Crooks PA, Smith C, Jordan CT. Rational Design of a Parthenolide-based Drug Regimen That Selectively Eradicates Acute Myelogenous Leukemia Stem Cells. J Biol Chem. 2016 Oct 14; 291(42):21984-22000. PMID: 27573247.
      View in: PubMed
    39. Han YS, Penthala NR, Oliveira M, Mesplède T, Xu H, Quan Y, Crooks PA, Wainberg MA. Identification of resveratrol analogs as potent anti-dengue agents using a cell-based assay. J Med Virol. 2017 03; 89(3):397-407. PMID: 27509184.
      View in: PubMed
    40. Nickell JR, Culver JP, Janganati V, Zheng G, Dwoskin LP, Crooks PA. Synthesis and in vitro evaluation of water-soluble 1,4-diphenethylpiperazine analogs as novel inhibitors of the vesicular monoamine transporter-2. Bioorg Med Chem Lett. 2016 09 15; 26(18):4441-4445. PMID: 27524311.
      View in: PubMed
    41. Laxmi SV, Anil P, Rajitha G, Rao AJ, Crooks PA, Rajitha B. Synthesis of thiazolidine-2,4-dione derivatives: anticancer, antimicrobial and DNA cleavage studies. J Chem Biol. 2016 Oct; 9(4):97-106. PMID: 27698947.
      View in: PubMed
    42. Sau A, Lau R, Cabrita MA, Nolan E, Crooks PA, Visvader JE, Pratt MA. Persistent Activation of NF-?B in BRCA1-Deficient Mammary Progenitors Drives Aberrant Proliferation and Accumulation of DNA Damage. Cell Stem Cell. 2016 07 07; 19(1):52-65. PMID: 27292187.
      View in: PubMed
    43. Liu X, Gujarathi S, Zhang X, Shao L, Boerma M, Compadre CM, Crooks PA, Hauer-Jensen M, Zhou D, Zheng G. Synthesis of (2R,8' S,3' E)-d-tocodienol, a tocoflexol family member designed to have a superior pharmacokinetic profile compared to d-tocotrienol. Tetrahedron. 2016 Jul; 72(27-28):4001-4006. PMID: 27773949.
      View in: PubMed
    44. Nickell JR, Culver JP, Janganati V, Zheng G, Dwoskin LP, Crooks PA. 1,4-Diphenalkylpiperidines: A new scaffold for the design of potent inhibitors of the vesicular monoamine transporter-2. Bioorg Med Chem Lett. 2016 07 01; 26(13):2997-3000. PMID: 27212067.
      View in: PubMed
    45. Penthala NR, Yadlapalli JK, Parkin S, Crooks PA. Crystal structures of (Z)-5-[2-(benzo[b]thio-phen-2-yl)-1-(3,5-di-meth-oxy-phen-yl)ethen-yl]-1H-tetra-zole and (Z)-5-[2-(benzo[b]thio-phen-3-yl)-1-(3,4,5-tri-meth-oxy-phen-yl)ethen-yl]-1H-tetra-zole. Acta Crystallogr E Crystallogr Commun. 2016 May 01; 72(Pt 5):652-5. PMID: 27308011.
      View in: PubMed
    46. Joolakanti SR, Nickell JR, Janganati V, Zheng G, Dwoskin LP, Crooks PA. Lobelane analogues containing 4-hydroxy and 4-(2-fluoroethoxy) aromatic substituents: Potent and selective inhibitors of [(3)H]dopamine uptake at the vesicular monoamine transporter-2. Bioorg Med Chem Lett. 2016 05 15; 26(10):2422-2427. PMID: 27080180.
      View in: PubMed
    47. Madadi NR, Ketkar A, Penthala NR, Bostian AC, Eoff RL, Crooks PA. Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells. Bioorg Med Chem Lett. 2016 May 01; 26(9):2164-9. PMID: 27017113.
      View in: PubMed
    48. Zong H, Sen S, Zhang G, Mu C, Albayati ZF, Gorenstein DG, Liu X, Ferrari M, Crooks PA, Roboz GJ, Shen H, Guzman ML. In vivo targeting of leukemia stem cells by directing parthenolide-loaded nanoparticles to the bone marrow niche. Leukemia. 2016 07; 30(7):1582-6. PMID: 26669973.
      View in: PubMed
    49. Albayati ZA, Sunkara M, Schmidt-Malan SM, Karau MJ, Morris AJ, Steckelberg JM, Patel R, Breen PJ, Smeltzer MS, Taylor KG, Merten KE, Pierce WM, Crooks PA. Novel Bone-Targeting Agent for Enhanced Delivery of Vancomycin to Bone. Antimicrob Agents Chemother. 2015 Dec 14; 60(3):1865-8. PMID: 26666918.
      View in: PubMed
    50. Bommagani S, Penthala NR, Parkin S, Crooks PA. Crystal structure of (E)-13-(pyrimidin-5-yl)parthenolide. Acta Crystallogr E Crystallogr Commun. 2015 Dec 01; 71(Pt 12):1536-8. PMID: 26870423.
      View in: PubMed
    51. Janganati V, Ponder J, Jordan CT, Borrelli MJ, Penthala NR, Crooks PA. Dimers of Melampomagnolide B Exhibit Potent Anticancer Activity against Hematological and Solid Tumor Cells. J Med Chem. 2015 Nov 25; 58(22):8896-906. PMID: 26540463.
      View in: PubMed
    52. Penthala NR, Ketkar A, Sekhar KR, Freeman ML, Eoff RL, Balusu R, Crooks PA. 1-Benzyl-2-methyl-3-indolylmethylene barbituric acid derivatives: Anti-cancer agents that target nucleophosmin 1 (NPM1). Bioorg Med Chem. 2015 Nov 15; 23(22):7226-33. PMID: 26602084.
      View in: PubMed
    53. Wan A, Penthala NR, Fifer EK, Parkin S, Crooks PA. Comparison of the crystal structures of 4,4'-bis-[3-(4-methyl-piperidin-1-yl)prop-1-yn-1-yl]-1,1'-biphenyl and 4,4'-bis-[3-(2,2,6,6-tetra-methyl-piperidin-1-yl)prop-1-yn-1-yl]-1,1'-biphen-yl. Acta Crystallogr E Crystallogr Commun. 2015 Oct 01; 71(Pt 10):1132-5. PMID: 26594389.
      View in: PubMed
    54. Wan A, Penthala NR, Fifer EK, Parkin S, Crooks PA. Comparison crystal structure conformations of two structurally related biphenyl analogues: 4,4'-bis-[3-(pyrrolidin-1-yl)prop-1-yn-1-yl]-1,1'-biphenyl and 4,4'-bis-{3-[(S)-2-methyl-pyrrolidin-1-yl]prop-1-yn-1-yl}-1,1'-biphen-yl. Acta Crystallogr E Crystallogr Commun. 2015 Oct 01; 71(Pt 10):1147-50. PMID: 26594393.
      View in: PubMed
    55. Madadi NR, Penthala NR, Howk K, Ketkar A, Eoff RL, Borrelli MJ, Crooks PA. Synthesis and biological evaluation of novel 4,5-disubstituted 2H-1,2,3-triazoles as cis-constrained analogues of combretastatin A-4. Eur J Med Chem. 2015 Oct 20; 103:123-32. PMID: 26352674.
      View in: PubMed
    56. Zheng G, Crooks PA. Synthesis of Lobeline, Lobelane and their Analogues. A Review. Org Prep Proced Int. 2015; 47(5):317-337. PMID: 26858465.
      View in: PubMed
    57. Beckmann JS, Meyer AC, Pivavarchyk M, Horton DB, Zheng G, Smith AM, Wooters TE, McIntosh JM, Crooks PA, Bardo MT, Dwoskin LP. r-bPiDI, an a6ß2* Nicotinic Receptor Antagonist, Decreases Nicotine-Evoked Dopamine Release and Nicotine Reinforcement. Neurochem Res. 2015 Oct; 40(10):2121-30. PMID: 26227997.
      View in: PubMed
    58. Penthala NR, Madhukuri L, Thakkar S, Madadi NR, Lamture G, Eoff RL, Crooks PA. Synthesis and anti-cancer screening of novel heterocyclic-(2H)-1,2,3-triazoles as potential anti-cancer agents. Medchemcomm. 2015 Aug 01; 6(8):1535-1543. PMID: 27066215.
      View in: PubMed
    59. Burnett RM, Craven KE, Krishnamurthy P, Goswami CP, Badve S, Crooks P, Mathews WP, Bhat-Nakshatri P, Nakshatri H. Organ-specific adaptive signaling pathway activation in metastatic breast cancer cells. Oncotarget. 2015 May 20; 6(14):12682-96. PMID: 25926557.
      View in: PubMed
    60. Penthala NR, Thakkar S, Crooks PA. Heteroaromatic analogs of the resveratrol analog DMU-212 as potent anti-cancer agents. Bioorg Med Chem Lett. 2015 Jul 15; 25(14):2763-7. PMID: 26022840.
      View in: PubMed
    61. Ding D, Nickell JR, Dwoskin LP, Crooks PA. Quinolyl analogues of norlobelane: novel potent inhibitors of [(3)H]dihydrotetrabenazine binding and [(3)H]dopamine uptake at the vesicular monoamine transporter-2. Bioorg Med Chem Lett. 2015 Jul 01; 25(13):2613-6. PMID: 25991431.
      View in: PubMed
    62. Madadi NR, Zong H, Ketkar A, Zheng C, Penthala NR, Janganati V, Bommagani S, Eoff RL, Guzman ML, Crooks PA. Synthesis and evaluation of a series of resveratrol analogues as potent anti-cancer agents that target tubulin. Medchemcomm. 2015 May 01; 6(3):788-794. PMID: 26257861.
      View in: PubMed
    63. Penthala NR, Crooks PA, Freeman ML, Sekhar KR. Development and validation of a novel assay to identify radiosensitizers that target nucleophosmin 1. Bioorg Med Chem. 2015 Jul 01; 23(13):3681-6. PMID: 25922180.
      View in: PubMed
    64. Holt JC, Kewin K, Jordan PM, Cameron P, Klapczynski M, McIntosh JM, Crooks PA, Dwoskin LP, Lysakowski A. Pharmacologically distinct nicotinic acetylcholine receptors drive efferent-mediated excitation in calyx-bearing vestibular afferents. J Neurosci. 2015 Feb 25; 35(8):3625-43. PMID: 25716861.
      View in: PubMed
    65. Nakshatri H, Appaiah HN, Anjanappa M, Gilley D, Tanaka H, Badve S, Crooks PA, Mathews W, Sweeney C, Bhat-Nakshatri P. NF-?B-dependent and -independent epigenetic modulation using the novel anti-cancer agent DMAPT. Cell Death Dis. 2015 Jan 22; 6:e1608. PMID: 25611383.
      View in: PubMed
    66. Karmakar A, Xu Y, Mustafa T, Kannarpady G, Bratton SM, Radominska-Pandya A, Crooks PA, Biris AS. Nanodelivery of Parthenolide Using Functionalized Nanographene Enhances its Anticancer Activity. RSC Adv. 2015 Jan 01; 5(4):2411-2420. PMID: 25574376.
      View in: PubMed
    67. Penthala NR, Zong H, Ketkar A, Madadi NR, Janganati V, Eoff RL, Guzman ML, Crooks PA. Synthesis, anticancer activity and molecular docking studies on a series of heterocyclic trans-cyanocombretastatin analogues as antitubulin agents. Eur J Med Chem. 2015 Mar 06; 92:212-20. PMID: 25557492.
      View in: PubMed
    68. Jang DS, Penthala NR, Apostolov EO, Wang X, Crooks PA, Basnakian AG. Novel cytoprotective inhibitors for apoptotic endonuclease G. DNA Cell Biol. 2015 Feb; 34(2):92-100. PMID: 25401220.
      View in: PubMed
    69. Gali R, Banothu J, Gondru R, Bavantula R, Velivela Y, Crooks PA. One-pot multicomponent synthesis of indole incorporated thiazolylcoumarins and their antibacterial, anticancer and DNA cleavage studies. Bioorg Med Chem Lett. 2015 Jan 01; 25(1):106-12. PMID: 25435148.
      View in: PubMed
    70. Penthala NR, Madadi NR, Bommagani S, Parkin S, Crooks PA. Comparison of crystal structures of 4-(benzo[b]thio-phen-2-yl)-5-(3,4,5-tri-meth-oxy-phen-yl)-2H-1,2,3-triazole and 4-(benzo[b]thio-phen-2-yl)-2-methyl-5-(3,4,5-tri-meth-oxy-phen-yl)-2H-1,2,3-triazole. Acta Crystallogr Sect E Struct Rep Online. 2014 Nov 01; 70(Pt 11):392-5. PMID: 25484755.
      View in: PubMed
    71. Jang DS, Penthala NR, Apostolov EO, Wang X, Fahmi T, Crooks PA, Basnakian AG. Novel high-throughput deoxyribonuclease 1 assay. J Biomol Screen. 2015 Feb; 20(2):202-11. PMID: 25326282.
      View in: PubMed
    72. Eldridge JA, Milewski M, Stinchcomb AL, Crooks PA. Synthesis and in vitro stability of amino acid prodrugs of 6-ß-naltrexol for microneedle-enhanced transdermal delivery. Bioorg Med Chem Lett. 2014 Nov 15; 24(22):5212-5. PMID: 25442314.
      View in: PubMed
    73. Penthala NR, Madadi NR, Janganati V, Crooks PA. L-Proline catalyzed one-step synthesis of 4,5-diaryl-2H-1,2,3-triazoles from heteroaryl cyanostilbenes via [3+2] cycloaddition of azide. Tetrahedron Lett. 2014 Oct 01; 55(40):5562-5565. PMID: 25267862.
      View in: PubMed
    74. Madadi NR, Penthala NR, Bommagani S, Parkin S, Crooks PA. Crystal structure of 4,5-bis-(3,4,5-tri-meth-oxy-phen-yl)-2H-1,2,3-triazole methanol monosolvate. Acta Crystallogr Sect E Struct Rep Online. 2014 Oct 01; 70(Pt 10):o1128-9. PMID: 25484710.
      View in: PubMed
    75. Penthala NR, Bommagani S, Janganati V, Parkin S, Crooks PA. Crystal structure of (E)-13-{4-[(Z)-2-cyano-2-(3,4,5-tri-meth-oxy-phen-yl)ethen-yl]phen-yl}parthenolide methanol hemisolvate. Acta Crystallogr Sect E Struct Rep Online. 2014 Oct 01; 70(Pt 10):o1092-3. PMID: 25484689.
      View in: PubMed
    76. Penthala NR, Bommagani S, Janganati V, MacNicol KB, Cragle CE, Madadi NR, Hardy LL, MacNicol AM, Crooks PA. Heck products of parthenolide and melampomagnolide-B as anticancer modulators that modify cell cycle progression. Eur J Med Chem. 2014 Oct 06; 85:517-25. PMID: 25117652.
      View in: PubMed
    77. Sekhar KR, Benamar M, Venkateswaran A, Sasi S, Penthala NR, Crooks PA, Hann SR, Geng L, Balusu R, Abbas T, Freeman ML. Targeting nucleophosmin 1 represents a rational strategy for radiation sensitization. Int J Radiat Oncol Biol Phys. 2014 Aug 01; 89(5):1106-1114. PMID: 25035215.
      View in: PubMed
    78. De Biasi M, McLaughlin I, Perez EE, Crooks PA, Dwoskin LP, Bardo MT, Pentel PR, Hatsukami D. Scientific overview: 2013 BBC plenary symposium on tobacco addiction. Drug Alcohol Depend. 2014 Aug 01; 141:107-17. PMID: 24934691.
      View in: PubMed
    79. Janganati V, Penthala NR, Madadi NR, Chen Z, Crooks PA. Anti-cancer activity of carbamate derivatives of melampomagnolide B. Bioorg Med Chem Lett. 2014 Aug 01; 24(15):3499-502. PMID: 24928404.
      View in: PubMed
    80. Franks LN, Ford BM, Madadi NR, Penthala NR, Crooks PA, Prather PL. Characterization of the intrinsic activity for a novel class of cannabinoid receptor ligands: Indole quinuclidine analogs. Eur J Pharmacol. 2014 Aug 15; 737:140-8. PMID: 24858620.
      View in: PubMed
    81. Greer AK, Madadi NR, Bratton SM, Eddy SD, Mazerska Z, Hendrickson HP, Crooks PA, Radominska-Pandya A. Novel resveratrol-based substrates for human hepatic, renal, and intestinal UDP-glucuronosyltransferases. Chem Res Toxicol. 2014 Apr 21; 27(4):536-45. PMID: 24571610.
      View in: PubMed
    82. Janganati V, Penthala NR, Cragle CE, MacNicol AM, Crooks PA. Heterocyclic aminoparthenolide derivatives modulate G(2)-M cell cycle progression during Xenopus oocyte maturation. Bioorg Med Chem Lett. 2014 Apr 15; 24(8):1963-7. PMID: 24656611.
      View in: PubMed
    83. Janganati V, Penthala NR, Madadi NR, Parkin S, Crooks PA. Monosuccinate ester of melampomagnolide B. Acta Crystallogr Sect E Struct Rep Online. 2014 Mar 01; 70(Pt 3):o372-3. PMID: 24765054.
      View in: PubMed
    84. Penthala NR, Bommagani S, Janganati V, Parkin S, Crooks PA. (E)-13-(2-Bromo-phen-yl)micheliolide. Acta Crystallogr Sect E Struct Rep Online. 2014 Mar 01; 70(Pt 3):o251-2. PMID: 24764970.
      View in: PubMed
    85. Nickell JR, Siripurapu KB, Vartak A, Crooks PA, Dwoskin LP. The vesicular monoamine transporter-2: an important pharmacological target for the discovery of novel therapeutics to treat methamphetamine abuse. Adv Pharmacol. 2014; 69:71-106. PMID: 24484975.
      View in: PubMed
    86. Crooks PA, Bardo MT, Dwoskin LP. Nicotinic receptor antagonists as treatments for nicotine abuse. Adv Pharmacol. 2014; 69:513-51. PMID: 24484986.
      View in: PubMed
    87. Madadi NR, Penthala NR, Janganati V, Crooks PA. Synthesis and anti-proliferative activity of aromatic substituted 5-((1-benzyl-1H-indol-3-yl)methylene)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione analogs against human tumor cell lines. Bioorg Med Chem Lett. 2014 Jan 15; 24(2):601-3. PMID: 24361000.
      View in: PubMed
    88. Bommagani S, Penthala NR, Janganati V, Parkin S, Crooks PA. 13-(N,N-Di-methyl-amino)-micheliolide 0.08-hydrate. Acta Crystallogr Sect E Struct Rep Online. 2013 Nov 20; 69(Pt 12):o1789-90. PMID: 24454230.
      View in: PubMed
    89. Venkateswaran A, Sekhar KR, Levic DS, Melville DB, Clark TA, Rybski WM, Walsh AJ, Skala MC, Crooks PA, Knapik EW, Freeman ML. The NADH oxidase ENOX1, a critical mediator of endothelial cell radiosensitization, is crucial for vascular development. Cancer Res. 2014 Jan 01; 74(1):38-43. PMID: 24247717.
      View in: PubMed
    90. Janganati V, Penthala NR, Parkin S, Crooks PA. 13-(Imidazol-1-yl)-11,13-di-hydro-melampomagnolide B monohydrate. Acta Crystallogr Sect E Struct Rep Online. 2013 Nov 06; 69(Pt 12):o1734-5. PMID: 24454194.
      View in: PubMed
    91. Penthala NR, Janganati V, Parkin S, Varughese KI, Crooks PA. (E)-13-(4-Amino-phen-yl)parthenolide. Acta Crystallogr Sect E Struct Rep Online. 2013 Oct 26; 69(Pt 11):o1709-10. PMID: 24454134.
      View in: PubMed
    92. Pei S, Minhajuddin M, Callahan KP, Balys M, Ashton JM, Neering SJ, Lagadinou ED, Corbett C, Ye H, Liesveld JL, O'Dwyer KM, Li Z, Shi L, Greninger P, Settleman J, Benes C, Hagen FK, Munger J, Crooks PA, Becker MW, Jordan CT. Targeting aberrant glutathione metabolism to eradicate human acute myelogenous leukemia cells. J Biol Chem. 2013 Nov 22; 288(47):33542-58. PMID: 24089526.
      View in: PubMed
    93. Wilmouth CE, Zheng G, Crooks PA, Dwoskin LP, Bardo MT. Oral administration of GZ-793A, a VMAT2 inhibitor, decreases methamphetamine self-administration in rats. Pharmacol Biochem Behav. 2013 Nov; 112:29-33. PMID: 24075974.
      View in: PubMed
    94. Ding D, Dwoskin LP, Crooks PA. Efficient synthesis of cis-2,6-di-(2- quinolylpiperidine). Tetrahedron Lett. 2013 Sep 18; 54(38):5211-5213. PMID: 24511163.
      View in: PubMed
    95. Banothu J, Gali R, Velpula R, Bavantula R, Crooks PA. An Eco-Friendly Improved Protocol for the Synthesis of Bis(3-indolyl)methanes Using Poly(4-vinylpyridinium)hydrogen Sulfate as Efficient, Heterogeneous, and Recyclable Solid Acid Catalyst. ISRN Org Chem. 2013; 2013:616932. PMID: 24052864.
      View in: PubMed
    96. Meyer AC, Neugebauer NM, Zheng G, Crooks PA, Dwoskin LP, Bardo MT. Effects of VMAT2 inhibitors lobeline and GZ-793A on methamphetamine-induced changes in dopamine release, metabolism and synthesis in vivo. J Neurochem. 2013 Oct; 127(2):187-98. PMID: 23875705.
      View in: PubMed
    97. Horton DB, Nickell JR, Zheng G, Crooks PA, Dwoskin LP. GZ-793A, a lobelane analog, interacts with the vesicular monoamine transporter-2 to inhibit the effect of methamphetamine. J Neurochem. 2013 Oct; 127(2):177-86. PMID: 23875622.
      View in: PubMed
    98. Ding D, Nickell JR, Deaciuc AG, Penthala NR, Dwoskin LP, Crooks PA. Synthesis and evaluation of novel azetidine analogs as potent inhibitors of vesicular [3H]dopamine uptake. Bioorg Med Chem. 2013 Nov 01; 21(21):6771-7. PMID: 23993667.
      View in: PubMed
    99. Peng C, Kimbrell MR, Tian C, Pack TF, Crooks PA, Fifer EK, Papke RL. Multiple modes of a7 nAChR noncompetitive antagonism of control agonist-evoked and allosterically enhanced currents. Mol Pharmacol. 2013 Sep; 84(3):459-75. PMID: 23839567.
      View in: PubMed
    100. Penthala NR, Sonar VN, Horn J, Leggas M, Yadlapalli JS, Crooks PA. Synthesis and evaluation of a series of benzothiophene acrylonitrile analogs as anticancer agents. Medchemcomm. 2013 Jul 01; 4(7):1073-1078. PMID: 23956835.
      View in: PubMed
    101. Coggins GE, Maddukuri L, Penthala NR, Hartman JH, Eddy S, Ketkar A, Crooks PA, Eoff RL. N-Aroyl indole thiobarbituric acids as inhibitors of DNA repair and replication stress response polymerases. ACS Chem Biol. 2013 Aug 16; 8(8):1722-9. PMID: 23679919.
      View in: PubMed
    102. Xu Y, Fang F, Miriyala S, Crooks PA, Oberley TD, Chaiswing L, Noel T, Holley AK, Zhao Y, Kiningham KK, Clair DK, Clair WH. KEAP1 is a redox sensitive target that arbitrates the opposing radiosensitive effects of parthenolide in normal and cancer cells. Cancer Res. 2013 Jul 15; 73(14):4406-17. PMID: 23674500.
      View in: PubMed
    103. Yip-Schneider MT, Wu H, Stantz K, Agaram N, Crooks PA, Schmidt CM. Dimethylaminoparthenolide and gemcitabine: a survival study using a genetically engineered mouse model of pancreatic cancer. BMC Cancer. 2013 Apr 17; 13:194. PMID: 23590467.
      View in: PubMed
    104. Penthala NR, Ponugoti PR, Nickell JR, Deaciuc AG, Dwoskin LP, Crooks PA. Pyrrolidine analogs of GZ-793A: synthesis and evaluation as inhibitors of the vesicular monoamine transporter-2 (VMAT2). Bioorg Med Chem Lett. 2013 Jun 01; 23(11):3342-5. PMID: 23597792.
      View in: PubMed
    105. Zheng G, Horton DB, Penthala NR, Nickell JR, Culver JP, Deaciuc AG, Dwoskin LP, Crooks PA. Exploring the effect of N-substitution in nor-lobelane on the interaction with VMAT2: discovery of a potential clinical candidate for treatment of methamphetamine abuse. Medchemcomm. 2013 Mar; 4(3):564-568. PMID: 23527317.
      View in: PubMed
    106. Madadi NR, Penthala NR, Brents LK, Ford BM, Prather PL, Crooks PA. Evaluation of (Z)-2-((1-benzyl-1H-indol-3-yl)methylene)-quinuclidin-3-one analogues as novel, high affinity ligands for CB1 and CB2 cannabinoid receptors. Bioorg Med Chem Lett. 2013 Apr 01; 23(7):2019-21. PMID: 23466226.
      View in: PubMed
    107. Ring JR, Zheng F, Haubner AJ, Littleton JM, Crooks PA. Improving the inhibitory activity of arylidenaminoguanidine compounds at the N-methyl-D-aspartate receptor complex from a recursive computational-experimental structure-activity relationship study. Bioorg Med Chem. 2013 Apr 01; 21(7):1764-74. PMID: 23465801.
      View in: PubMed
    108. Penthala NR, Crooks PA. rac-N-Benzyl-isatincreatinine (unknown solvate). Acta Crystallogr Sect E Struct Rep Online. 2013 Feb 01; 69(Pt 2):o290-1. PMID: 23424560.
      View in: PubMed
    109. Penthala NR, Crooks PA. rac-5-Bromo-N-benzyl-isatincreatinine ethanol monosolvate. Acta Crystallogr Sect E Struct Rep Online. 2013 Feb 01; 69(Pt 2):o288-9. PMID: 23424559.
      View in: PubMed
    110. Yip-Schneider MT, Wu H, Hruban RH, Lowy AM, Crooks PA, Schmidt CM. Efficacy of dimethylaminoparthenolide and sulindac in combination with gemcitabine in a genetically engineered mouse model of pancreatic cancer. Pancreas. 2013 Jan; 42(1):160-7. PMID: 22699205.
      View in: PubMed
    111. Adeneye Adejuwon A, Crooks PA, Fadhel-Albayati Z, Miller AF, Zito SW, Adeyemi OO, Agbaje EO. Antihyperglycemic profile of erinidine isolated from Hunteria umbellata seed. Afr J Tradit Complement Altern Med. 2013; 10(2):189-202. PMID: 24146442.
      View in: PubMed
    112. Penthala NR, Ponugoti PR, Kasam V, Crooks PA. 5-((1-Aroyl-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-diones as potential anticancer agents with anti-inflammatory properties. Bioorg Med Chem Lett. 2013 Mar 01; 23(5):1442-6. PMID: 23339966.
      View in: PubMed
    113. Sonar VN, Parkin S, Crooks PA. Oxycodone N-oxide. Acta Crystallogr C. 2012 Nov; 68(Pt 11):o436-8. PMID: 23124457.
      View in: PubMed
    114. Penthala NR, Ponugoti PR, Parkin S, Crooks PA. rac-(Z)-Methyl 1-benzyl-3-[(3-hy-droxy-quinuclidin-2-yl-idene)meth-yl]-1H-indole-6-carboxyl-ate. Acta Crystallogr Sect E Struct Rep Online. 2012 Nov 01; 68(Pt 11):o3111. PMID: 23284437.
      View in: PubMed
    115. Venkateswaran A, Friedman DB, Walsh AJ, Skala MC, Sasi S, Rachakonda G, Crooks PA, Freeman ML, Sekhar KR. The novel antiangiogenic VJ115 inhibits the NADH oxidase ENOX1 and cytoskeleton-remodeling proteins. Invest New Drugs. 2013 Jun; 31(3):535-44. PMID: 23054211.
      View in: PubMed
    116. Sonar VN, Parkin S, Crooks PA. The effect of hydrogen bonding on the conformations of 2-(1H-indol-3-yl)-2-oxoacetamide and 2-(1H-indol-3-yl)-N,N-dimethyl-2-oxoacetamide. Acta Crystallogr C. 2012 Oct; 68(Pt 10):o405-7. PMID: 23007543.
      View in: PubMed
    117. Barron S, Lewis B, Wellmann K, Carter M, Farook J, Ring J, Rogers DT, Holley R, Crooks P, Littleton J. Polyamine modulation of NMDARs as a mechanism to reduce effects of alcohol dependence. Recent Pat CNS Drug Discov. 2012 Aug; 7(2):129-44. PMID: 22574674.
      View in: PubMed
    118. Alvers KM, Beckmann JS, Zheng G, Crooks PA, Dwoskin LP, Bardo MT. The effect of VMAT2 inhibitor GZ-793A on the reinstatement of methamphetamine-seeking in rats. Psychopharmacology (Berl). 2012 Nov; 224(2):255-62. PMID: 22638813.
      View in: PubMed
    119. Holcomb BK, Yip-Schneider MT, Waters JA, Beane JD, Crooks PA, Schmidt CM. Dimethylamino parthenolide enhances the inhibitory effects of gemcitabine in human pancreatic cancer cells. J Gastrointest Surg. 2012 Jul; 16(7):1333-40. PMID: 22618517.
      View in: PubMed
    120. Wala EP, Crooks PA, McIntosh JM, Holtman JR. Novel small molecule a9a10 nicotinic receptor antagonist prevents and reverses chemotherapy-evoked neuropathic pain in rats. Anesth Analg. 2012 Sep; 115(3):713-20. PMID: 22610850.
      View in: PubMed
    121. Penthala NR, Parkin S, Crooks PA. (Z)-3-(1H-Indol-3-yl)-2-(3,4,5-tri-methoxy-phen-yl)acrylonitrile. Acta Crystallogr Sect E Struct Rep Online. 2012 Mar 01; 68(Pt 3):o729. PMID: 22412611.
      View in: PubMed
    122. Madadi NR, Parkin S, Crooks PA. (Z)-2-{2,4-Dimeth-oxy-6-[(E)-4-meth-oxy-styr-yl]benzyl-idene}quinuclidin-3-one. Acta Crystallogr Sect E Struct Rep Online. 2012 Mar 01; 68(Pt 3):o730. PMID: 22412612.
      View in: PubMed
    123. Penthala NR, Parkin S, Crooks PA. (Z)-3-(1-Benzofuran-2-yl)-2-(3,4,5-tri-meth-oxy-phen-yl)acrylonitrile. Acta Crystallogr Sect E Struct Rep Online. 2012 Mar 01; 68(Pt 3):o731. PMID: 22412613.
      View in: PubMed
    124. Estabrook NC, Chin-Sinex H, Borgmann AJ, Dhaemers RM, Shapiro RH, Gilley D, Huda N, Crooks P, Sweeney C, Mendonca MS. Inhibition of NF-?B and DNA double-strand break repair by DMAPT sensitizes non-small-cell lung cancers to X-rays. Free Radic Biol Med. 2011 Dec 15; 51(12):2249-58. PMID: 22019440.
      View in: PubMed
    125. Beckmann JS, Denehy ED, Zheng G, Crooks PA, Dwoskin LP, Bardo MT. The effect of a novel VMAT2 inhibitor, GZ-793A, on methamphetamine reward in rats. Psychopharmacology (Berl). 2012 Mar; 220(2):395-403. PMID: 21938414.
      View in: PubMed
    126. Holtman JR, Dwoskin LP, Dowell C, Wala EP, Zhang Z, Crooks PA, McIntosh JM. The novel small molecule a9a10 nicotinic acetylcholine receptor antagonist ZZ-204G is analgesic. Eur J Pharmacol. 2011 Nov 30; 670(2-3):500-8. PMID: 21944926.
      View in: PubMed
    127. Sekhar KR, Reddy YT, Reddy PN, Crooks PA, Venkateswaran A, McDonald WH, Geng L, Sasi S, Van Der Waal RP, Roti JL, Salleng KJ, Rachakonda G, Freeman ML. The novel chemical entity YTR107 inhibits recruitment of nucleophosmin to sites of DNA damage, suppressing repair of DNA double-strand breaks and enhancing radiosensitization. Clin Cancer Res. 2011 Oct 15; 17(20):6490-9. PMID: 21878537.
      View in: PubMed
    128. Horton DB, Siripurapu KB, Zheng G, Crooks PA, Dwoskin LP. Novel N-1,2-dihydroxypropyl analogs of lobelane inhibit vesicular monoamine transporter-2 function and methamphetamine-evoked dopamine release. J Pharmacol Exp Ther. 2011 Oct; 339(1):286-97. PMID: 21778282.
      View in: PubMed
    129. Nasim S, Guzman ML, Jordan CT, Crooks PA. Discovery of 1,2,4-thiadiazolidine-3,5-dione analogs that exhibit unusual and selective rapid cell death kinetics against acute myelogenous leukemia cells in culture. Bioorg Med Chem Lett. 2011 Aug 15; 21(16):4879-83. PMID: 21757349.
      View in: PubMed
    130. Vijaya Laxmi S, Thirupathi Reddy Y, Suresh Kuarm B, Narsimha Reddy P, Crooks PA, Rajitha B. Synthesis and evaluation of chromenyl barbiturates and thiobarbiturates as potential antitubercular agents. Bioorg Med Chem Lett. 2011 Jul 15; 21(14):4329-31. PMID: 21684158.
      View in: PubMed
    131. Zhang Z, Dwoskin LP, Crooks PA. Expeditious synthesis of cis-1-methyl-2, 3,3a,4,5,9b-hexahydro-1H-pyrrolo-[3,2h]isoquinoline / [2,3-f]quinoline via azomethine ylide-alkene [3+2] cycloaddition. Tetrahedron Lett. 2011 May 25; 52(21):2667-2669. PMID: 23908558.
      View in: PubMed
    132. Shanmugam R, Kusumanchi P, Appaiah H, Cheng L, Crooks P, Neelakantan S, Peat T, Klaunig J, Matthews W, Nakshatri H, Sweeney CJ. A water soluble parthenolide analog suppresses in vivo tumor growth of two tobacco-associated cancers, lung and bladder cancer, by targeting NF-?B and generating reactive oxygen species. Int J Cancer. 2011 May 15; 128(10):2481-94. PMID: 20669221.
      View in: PubMed
    133. Wooters TE, Smith AM, Pivavarchyk M, Siripurapu KB, McIntosh JM, Zhang Z, Crooks PA, Bardo MT, Dwoskin LP. bPiDI: a novel selective a6ß2* nicotinic receptor antagonist and preclinical candidate treatment for nicotine abuse. Br J Pharmacol. 2011 May; 163(2):346-57. PMID: 21232049.
      View in: PubMed
    134. Biermann M, Hardcastle KI, Moskalev NV, Crooks PA. (S)-2-Amino-2-(2-chloro-phen-yl)cyclo-hexa-none. Acta Crystallogr Sect E Struct Rep Online. 2011 Apr 01; 67(Pt 4):o936. PMID: 21754205.
      View in: PubMed
    135. Ponugoti PR, Penthala NR, Dwoskin LP, Parkin S, Crooks PA. cis-1-Benzyl-pyrrolidine-2,5-dicarbonitrile. Acta Crystallogr Sect E Struct Rep Online. 2011 Apr 01; 67(Pt 4):o747. PMID: 21754044.
      View in: PubMed
    136. Pivavarchyk M, Smith AM, Zhang Z, Zhou D, Wang X, Toyooka N, Tsuneki H, Sasaoka T, McIntosh JM, Crooks PA, Dwoskin LP. Indolizidine (-)-235B' and related structural analogs: discovery of nicotinic receptor antagonists that inhibit nicotine-evoked [3H]dopamine release. Eur J Pharmacol. 2011 May 11; 658(2-3):132-9. PMID: 21371454.
      View in: PubMed
    137. Al-Ghananeem AM, Malkawi AH, Crooks PA. Bioavailability of ??-tetrahydrocannabinol following intranasal administration of a mucoadhesive gel spray delivery system in conscious rabbits. Drug Dev Ind Pharm. 2011 Mar; 37(3):329-34. PMID: 21244195.
      View in: PubMed
    138. Ponugoti PR, Penthala NR, Dwoskin LP, Parkin S, Crooks PA. cis-2,5-Bis(2-fluoro-5-meth-oxy-pheneth-yl)pyrrolidinium formate. Acta Crystallogr Sect E Struct Rep Online. 2011 Feb 26; 67(Pt 3):o737. PMID: 21522476.
      View in: PubMed
    139. Hojahmat M, Zheng G, Siegler M, Parkin S, Biermann M, Crooks PA. (S)-1-(2-Chloro-phen-yl)-2-oxocyclo-hexan-1-aminium d-tartrate. Acta Crystallogr Sect E Struct Rep Online. 2011 Feb 26; 67(Pt 3):o736. PMID: 21522475.
      View in: PubMed
    140. Penthala NR, Reddy TR, Parkin S, Crooks PA. (2Z,3E)-2-{[1-(4-Chloro-benz-yl)-1H-indol-3-yl]methyl-idene}quinuclidin-3-one oxime. Acta Crystallogr Sect E Struct Rep Online. 2011 Feb 26; 67(Pt 3):o735. PMID: 21522474.
      View in: PubMed
    141. Zheng G, Zhang Z, Dowell C, Wala E, Dwoskin LP, Holtman JR, McIntosh JM, Crooks PA. Discovery of non-peptide, small molecule antagonists of a9a10 nicotinic acetylcholine receptors as novel analgesics for the treatment of neuropathic and tonic inflammatory pain. Bioorg Med Chem Lett. 2011 Apr 15; 21(8):2476-9. PMID: 21397497.
      View in: PubMed
    142. Penthala NR, Yerramreddy TR, Crooks PA. Synthesis and in vitro screening of novel N-benzyl aplysinopsin analogs as potential anticancer agents. Bioorg Med Chem Lett. 2011 Mar 01; 21(5):1411-3. PMID: 21295476.
      View in: PubMed
    143. Nasim S, Pei S, Hagen FK, Jordan CT, Crooks PA. Melampomagnolide B: a new antileukemic sesquiterpene. Bioorg Med Chem. 2011 Feb 15; 19(4):1515-9. PMID: 21273084.
      View in: PubMed
    144. Crooks PA, Zheng G, Vartak AP, Culver JP, Zheng F, Horton DB, Dwoskin LP. Design, synthesis and interaction at the vesicular monoamine transporter-2 of lobeline analogs: potential pharmacotherapies for the treatment of psychostimulant abuse. Curr Top Med Chem. 2011; 11(9):1103-27. PMID: 21050177.
      View in: PubMed
    145. Horton DB, Siripurapu KB, Norrholm SD, Culver JP, Hojahmat M, Beckmann JS, Harrod SB, Deaciuc AG, Bardo MT, Crooks PA, Dwoskin LP. meso-Transdiene analogs inhibit vesicular monoamine transporter-2 function and methamphetamine-evoked dopamine release. J Pharmacol Exp Ther. 2011 Mar; 336(3):940-51. PMID: 21177475.
      View in: PubMed
    146. Zhang Z, Zheng G, Pivavarchyk M, Deaciuc AG, Dwoskin LP, Crooks PA. Novel bis-, tris-, and tetrakis-tertiary amino analogs as antagonists at neuronal nicotinic receptors that mediate nicotine-evoked dopamine release. Bioorg Med Chem Lett. 2011 Jan 01; 21(1):88-91. PMID: 21147530.
      View in: PubMed
    147. Kuarm BS, Reddy YT, Madhav JV, Crooks PA, Rajitha B. 3-[Benzimidazo- and 3-[benzothiadiazoleimidazo-(1,2-c)quinazolin-5-yl]-2H-chromene-2-ones as potent antimicrobial agents. Bioorg Med Chem Lett. 2011 Jan 01; 21(1):524-7. PMID: 21134751.
      View in: PubMed
    148. Venkateswaran A, Reddy YT, Sonar VN, Muthusamy V, Crooks PA, Freeman ML, Sekhar KR. Antiangiogenic properties of substituted (Z)-(±)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-ol/one analogs and their derivatives. Bioorg Med Chem Lett. 2010 Dec 15; 20(24):7323-6. PMID: 21055930.
      View in: PubMed
    149. Nasim S, Vartak AP, Pierce WM, Taylor KG, Smith N, Crooks PA. 3-O-phosphate ester conjugates of 17-ß-O-{1-[2-carboxy-(2-hydroxy-4-methoxy-3-carboxamido)anilido]ethyl}1,3,5(10)-estratriene as novel bone-targeting agents. Bioorg Med Chem Lett. 2010 Dec 15; 20(24):7450-3. PMID: 21055931.
      View in: PubMed
    150. Hassane DC, Sen S, Minhajuddin M, Rossi RM, Corbett CA, Balys M, Wei L, Crooks PA, Guzman ML, Jordan CT. Chemical genomic screening reveals synergism between parthenolide and inhibitors of the PI-3 kinase and mTOR pathways. Blood. 2010 Dec 23; 116(26):5983-90. PMID: 20889920.
      View in: PubMed
    151. Nickell JR, Zheng G, Deaciuc AG, Crooks PA, Dwoskin LP. Phenyl ring-substituted lobelane analogs: inhibition of [³H]dopamine uptake at the vesicular monoamine transporter-2. J Pharmacol Exp Ther. 2011 Mar; 336(3):724-33. PMID: 20876747.
      View in: PubMed
    152. Holtman JR, Crooks PA, Johnson-Hardy J, Wala EP. Antinociceptive effects and toxicity of morphine-6-O-sulfate sodium salt in rat models of pain. Eur J Pharmacol. 2010 Dec 01; 648(1-3):87-94. PMID: 20828549.
      View in: PubMed
    153. Beckmann JS, Siripurapu KB, Nickell JR, Horton DB, Denehy ED, Vartak A, Crooks PA, Dwoskin LP, Bardo MT. The novel pyrrolidine nor-lobelane analog UKCP-110 [cis-2,5-di-(2-phenethyl)-pyrrolidine hydrochloride] inhibits VMAT2 function, methamphetamine-evoked dopamine release, and methamphetamine self-administration in rats. J Pharmacol Exp Ther. 2010 Dec; 335(3):841-51. PMID: 20805303.
      View in: PubMed
    154. Shanmugam R, Kusumanchi P, Cheng L, Crooks P, Neelakantan S, Matthews W, Nakshatri H, Sweeney CJ. A water-soluble parthenolide analogue suppresses in vivo prostate cancer growth by targeting NFkappaB and generating reactive oxygen species. Prostate. 2010 Jul 01; 70(10):1074-86. PMID: 20209491.
      View in: PubMed
    155. Banks SL, Pinninti RR, Gill HS, Paudel KS, Crooks PA, Brogden NK, Prausnitz MR, Stinchcomb AL. Transdermal delivery of naltrexol and skin permeability lifetime after microneedle treatment in hairless guinea pigs. J Pharm Sci. 2010 Jul; 99(7):3072-80. PMID: 20166200.
      View in: PubMed
    156. Penthala NR, Eldridge J, Reddy TR, Parkin S, Crooks PA. (E,E)-1-Methyl-2,6-distyrylpyridinium iodide. Acta Crystallogr Sect E Struct Rep Online. 2010 Jun 26; 66(Pt 7):o1793. PMID: 21588003.
      View in: PubMed
    157. Madadi NR, Reddy TR, Penthala NR, Parkin S, Crooks PA. (Z)-2-Amino-5-[2,4-dimeth-oxy-6-(4-methoxy-styr-yl)benzyl-idene]-1,3-thia-zol-4(5H)-one methanol solvate. Acta Crystallogr Sect E Struct Rep Online. 2010 Jun 26; 66(Pt 7):o1792. PMID: 21588002.
      View in: PubMed
    158. Penthala NR, Yerramreddy TR, Madadi NR, Crooks PA. Synthesis and in vitro evaluation of N-alkyl-3-hydroxy-3-(2-imino-3-methyl-5-oxoimidazolidin-4-yl)indolin-2-one analogs as potential anticancer agents. Bioorg Med Chem Lett. 2010 Aug 01; 20(15):4468-71. PMID: 20598531.
      View in: PubMed
    159. Milewski M, Yerramreddy TR, Ghosh P, Crooks PA, Stinchcomb AL. In vitro permeation of a pegylated naltrexone prodrug across microneedle-treated skin. J Control Release. 2010 Aug 17; 146(1):37-44. PMID: 20678989.
      View in: PubMed
    160. Walsby EJ, Pratt G, Hewamana S, Crooks PA, Burnett AK, Fegan C, Pepper C. The NF-kappaB inhibitor LC-1 has single agent activity in multiple myeloma cells and synergizes with bortezomib. Mol Cancer Ther. 2010 Jun; 9(6):1574-82. PMID: 20515939.
      View in: PubMed
    161. Vartak AP, Gabriela Deaciuc A, Dwoskin LP, Crooks PA. Quinlobelane: a water-soluble lobelane analogue and inhibitor of VMAT2. Bioorg Med Chem Lett. 2010 Jun 15; 20(12):3584-7. PMID: 20494575.
      View in: PubMed
    162. Zheng G, Zhang Z, Lockman PR, Geldenhuys WJ, Allen DD, Dwoskin LP, Crooks PA. Bis-azaaromatic quaternary ammonium salts as ligands for the blood-brain barrier choline transporter. Bioorg Med Chem Lett. 2010 Jun 01; 20(11):3208-10. PMID: 20462759.
      View in: PubMed
    163. Matharu J, Oki J, Worthen DR, Smith QR, Crooks PA. Regiospecific and conformationally restrained analogs of melphalan and DL-2-NAM-7 and their affinities for the large neutral amino acid transporter (system LAT1) of the blood-brain barrier. Bioorg Med Chem Lett. 2010 Jun 15; 20(12):3688-91. PMID: 20466543.
      View in: PubMed
    164. Yerramreddy TR, Milewski M, Penthala NR, Stinchcomb AL, Crooks PA. Novel 3-O-pegylated carboxylate and 3-O-pegylated carbamate prodrugs of naltrexone for microneedle-enhanced transdermal delivery. Bioorg Med Chem Lett. 2010 Jun 01; 20(11):3280-3. PMID: 20451376.
      View in: PubMed
    165. Thirupathi Reddy Y, Narsimha Reddy P, Koduru S, Damodaran C, Crooks PA. Aplysinopsin analogs: Synthesis and anti-proliferative activity of substituted (Z)-5-(N-benzylindol-3-ylmethylene)imidazolidine-2,4-diones. Bioorg Med Chem. 2010 May 15; 18(10):3570-4. PMID: 20403701.
      View in: PubMed
    166. Smith AM, Pivavarchyk M, Wooters TE, Zhang Z, Zheng G, McIntosh JM, Crooks PA, Bardo MT, Dwoskin LP. Repeated nicotine administration robustly increases bPiDDB inhibitory potency at alpha6beta2-containing nicotinic receptors mediating nicotine-evoked dopamine release. Biochem Pharmacol. 2010 Aug 01; 80(3):402-9. PMID: 20346923.
      View in: PubMed
    167. Sun Y, St Clair DK, Xu Y, Crooks PA, St Clair WH. A NADPH oxidase-dependent redox signaling pathway mediates the selective radiosensitization effect of parthenolide in prostate cancer cells. Cancer Res. 2010 Apr 01; 70(7):2880-90. PMID: 20233868.
      View in: PubMed
    168. Zhang Z, Pivavarchyk M, Subramanian KL, Deaciuc AG, Dwoskin LP, Crooks PA. Novel bis-2,2,6,6-tetramethylpiperidine (bis-TMP) and bis-mecamylamine antagonists at neuronal nicotinic receptors mediating nicotine-evoked dopamine release. Bioorg Med Chem Lett. 2010 Feb 15; 20(4):1420-3. PMID: 20079634.
      View in: PubMed
    169. Geldenhuys WJ, Manda VK, Mittapalli RK, Van der Schyf CJ, Crooks PA, Dwoskin LP, Allen DD, Lockman PR. Predictive screening model for potential vector-mediated transport of cationic substrates at the blood-brain barrier choline transporter. Bioorg Med Chem Lett. 2010 Feb 01; 20(3):870-7. PMID: 20053562.
      View in: PubMed
    170. Vartak AP, Nickell JR, Chagkutip J, Dwoskin LP, Crooks PA. Pyrrolidine analogues of lobelane: relationship of affinity for the dihydrotetrabenazine binding site with function of the vesicular monoamine transporter 2 (VMAT2). J Med Chem. 2009 Dec 10; 52(23):7878-82. PMID: 19691331.
      View in: PubMed
    171. Zheng G, Parkin S, Dwoskin LP, Crooks PA. (2S,6S)-1-Methyl-2,6-trans-distyryl-piperidinium chloride. Acta Crystallogr Sect E Struct Rep Online. 2009 Dec 09; 66(Pt 1):o78. PMID: 21580177.
      View in: PubMed
    172. Zheng G, Parkin S, Dwoskin LP, Crooks PA. 1-Methyl-2,6-cis-distyrylpiperidine. Acta Crystallogr Sect E Struct Rep Online. 2009 Dec 09; 66(Pt 1):o77. PMID: 21580176.
      View in: PubMed
    173. Hojahmat M, Horton DB, Norrholm SD, Miller DK, Grinevich VP, Deaciuc AG, Dwoskin LP, Crooks PA. Lobeline esters as novel ligands for neuronal nicotinic acetylcholine receptors and neurotransmitter transporters. Bioorg Med Chem. 2010 Jan 15; 18(2):640-9. PMID: 20036131.
      View in: PubMed
    174. Penthala NR, Yerramreddy TR, Crooks PA. Microwave assisted synthesis and in vitro cytotoxicities of substituted (Z)-2-amino-5-(1-benzyl-1H-indol-3-yl)methylene-1-methyl-1H-imidazol-4(5H)-ones against human tumor cell lines. Bioorg Med Chem Lett. 2010 Jan 15; 20(2):591-3. PMID: 20006496.
      View in: PubMed
    175. Reddy YT, Sekhar KR, Sasi N, Reddy PN, Freeman ML, Crooks PA. Novel substituted (Z)-5-((N-benzyl-1H-indol-3-yl)methylene)imidazolidine-2,4-diones and 5-((N-benzyl-1H-indol-3-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-triones as potent radio-sensitizing agents. Bioorg Med Chem Lett. 2010 Jan 15; 20(2):600-2. PMID: 20005706.
      View in: PubMed
    176. Penthala NR, Reddy TR, Parkin S, Crooks PA. 3-(2-Amino-1-methyl-4-oxo-4,5-dihydro-1H-imidazol-5-yl)-5-fluoro-3-hydr-oxy-1-methyl-indolin-2-one methanol hemisolvate. Acta Crystallogr Sect E Struct Rep Online. 2009 Oct 31; 65(Pt 11):o2909-10. PMID: 21578489.
      View in: PubMed
    177. Nickell JR, Krishnamurthy S, Norrholm S, Deaciuc G, Siripurapu KB, Zheng G, Crooks PA, Dwoskin LP. Lobelane inhibits methamphetamine-evoked dopamine release via inhibition of the vesicular monoamine transporter-2. J Pharmacol Exp Ther. 2010 Feb; 332(2):612-21. PMID: 19855096.
      View in: PubMed
    178. Holtman JR, Crooks PA, Johnson-Hardy JK, Wala EP. The analgesic and toxic effects of nornicotine enantiomers alone and in interaction with morphine in rodent models of acute and persistent pain. Pharmacol Biochem Behav. 2010 Jan; 94(3):352-62. PMID: 19800911.
      View in: PubMed
    179. Zheng F, Dwoskin LP, Crooks PA, Zhan CG. First-Principles Determination of Molecular Conformations of Indolizidine (-)-235B' in Solution. Theor Chem Acc. 2009 Oct 01; 124(3-4):269-278. PMID: 20161506.
      View in: PubMed
    180. Struthers AM, Wilkinson JL, Dwoskin LP, Crooks PA, Bevins RA. Mecamylamine, dihydro-beta-erythroidine, and dextromethorphan block conditioned responding evoked by the conditional stimulus effects of nicotine. Pharmacol Biochem Behav. 2009 Dec; 94(2):319-28. PMID: 19778551.
      View in: PubMed
    181. Penthala NR, Reddy TR, Parkin S, Crooks PA. 3-(2-Amino-1-methyl-4-oxo-4,5-dihydro-1H-imidazol-5-yl)-3-hydr-oxy-1-phenyl-indolin-2-one ethanol solvate. Acta Crystallogr Sect E Struct Rep Online. 2009 Sep 12; 65(Pt 10):o2439-40. PMID: 21577895.
      View in: PubMed
    182. Zheng G, Dwoskin LP, Deaciuc AG, Crooks PA. Stereocontrolled synthesis and pharmacological evaluation of cis-2,6-diphenethyl-1-azabicyclo[2.2.2]octanes as lobelane analogues. J Org Chem. 2009 Aug 21; 74(16):6072-6. PMID: 20560567.
      View in: PubMed
    183. Neelakantan S, Surjawan I, Karacelik H, Hicks CL, Crooks PA. Synthesis of novel isoluminol probes and their use in rapid bacterial assays. Bioorg Med Chem Lett. 2009 Oct 01; 19(19):5722-6. PMID: 19700327.
      View in: PubMed
    184. Vaddi HK, Banks SL, Chen J, Hammell DC, Crooks PA, Stinchcomb AL. Human skin permeation of 3-O-alkyl carbamate prodrugs of naltrexone. J Pharm Sci. 2009 Aug; 98(8):2611-25. PMID: 18972573.
      View in: PubMed
    185. Smith AM, Dhawan GK, Zhang Z, Siripurapu KB, Crooks PA, Dwoskin LP. The novel nicotinic receptor antagonist, N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide (bPiDDB), inhibits nicotine-evoked [(3)H]norepinephrine overflow from rat hippocampal slices. Biochem Pharmacol. 2009 Oct 01; 78(7):889-97. PMID: 19631612.
      View in: PubMed
    186. Penthala NR, Reddy TR, Parkin S, Crooks PA. rac-2-(2-Amino-4-oxo-4,5-dihydro-1,3-thia-zol-5-yl)-2-hydroxy-indane-1,3-dione. Acta Crystallogr Sect E Struct Rep Online. 2009 Jul 18; 65(Pt 8):o1877. PMID: 21583571.
      View in: PubMed
    187. Worthen DR, Bence AK, Stables JP, Crooks PA. In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity. Bioorg Med Chem Lett. 2009 Sep 01; 19(17):5012-5. PMID: 19632831.
      View in: PubMed
    188. López-Hernández GY, Thinschmidt JS, Zheng G, Zhang Z, Crooks PA, Dwoskin LP, Papke RL. Selective inhibition of acetylcholine-evoked responses of alpha7 neuronal nicotinic acetylcholine receptors by novel tris- and tetrakis-azaaromatic quaternary ammonium antagonists. Mol Pharmacol. 2009 Sep; 76(3):652-66. PMID: 19556356.
      View in: PubMed
    189. Neelakantan S, Parkin S, Crooks PA. (11R)-13-Dimethyl-ammonio-11,13-dihydro-4,5-epoxy-costunolide semifumarate. Acta Crystallogr Sect E Struct Rep Online. 2009 Jun 13; 65(Pt 7):o1569. PMID: 21582849.
      View in: PubMed
    190. Dwoskin LP, Smith AM, Wooters TE, Zhang Z, Crooks PA, Bardo MT. Nicotinic receptor-based therapeutics and candidates for smoking cessation. Biochem Pharmacol. 2009 Oct 01; 78(7):732-43. PMID: 19523455.
      View in: PubMed
    191. Neelakantan S, Nasim S, Guzman ML, Jordan CT, Crooks PA. Aminoparthenolides as novel anti-leukemic agents: Discovery of the NF-kappaB inhibitor, DMAPT (LC-1). Bioorg Med Chem Lett. 2009 Aug 01; 19(15):4346-9. PMID: 19505822.
      View in: PubMed
    192. Zheng F, McConnell MJ, Zhan CG, Dwoskin LP, Crooks PA. QSAR study on maximal inhibition (Imax) of quaternary ammonium antagonists for S-(-)-nicotine-evoked dopamine release from dopaminergic nerve terminals in rat striatum. Bioorg Med Chem. 2009 Jul 01; 17(13):4477-85. PMID: 19477134.
      View in: PubMed
    193. Geng L, Rachakonda G, Morré DJ, Morré DM, Crooks PA, Sonar VN, Roti JL, Rogers BE, Greco S, Ye F, Salleng KJ, Sasi S, Freeman ML, Sekhar KR. Indolyl-quinuclidinols inhibit ENOX activity and endothelial cell morphogenesis while enhancing radiation-mediated control of tumor vasculature. FASEB J. 2009 Sep; 23(9):2986-95. PMID: 19395476.
      View in: PubMed
    194. Culver JP, Parkin S, Crooks PA. cis-2,6-Dibenzyl-cyclo-hexa-none. Acta Crystallogr Sect E Struct Rep Online. 2009 Feb 21; 65(Pt 3):o551. PMID: 21582210.
      View in: PubMed
    195. Penthala NR, Reddy TR, Parkin S, Crooks PA. 3-(2-Amino-1-methyl-4-oxo-4,5-dihydro-1H-imidazol-5-yl)-3-hydroxy-indolin-2-one monohydrate. Acta Crystallogr Sect E Struct Rep Online. 2009 Feb 21; 65(Pt 3):o552. PMID: 21582211.
      View in: PubMed
    196. Kiptoo PK, Paudel KS, Hammell DC, Pinninti RR, Chen J, Crooks PA, Stinchcomb AL. Transdermal delivery of bupropion and its active metabolite, hydroxybupropion: a prodrug strategy as an alternative approach. J Pharm Sci. 2009 Feb; 98(2):583-94. PMID: 18623203.
      View in: PubMed
    197. Sonar VN, Crooks PA. Synthesis and antitubercular activity of a series of hydrazone and nitrovinyl analogs derived from heterocyclic aldehydes. J Enzyme Inhib Med Chem. 2009 Feb; 24(1):117-24. PMID: 18629678.
      View in: PubMed
    198. Zheng F, Zheng G, Deaciuc AG, Zhan CG, Dwoskin LP, Crooks PA. Computational neural network analysis of the affinity of N-n-alkylnicotinium salts for the alpha4beta2* nicotinic acetylcholine receptor. J Enzyme Inhib Med Chem. 2009 Feb; 24(1):157-68. PMID: 18629679.
      View in: PubMed
    199. Dwoskin LP, Pivavarchyk M, Joyce BM, Neugebauer NM, Zheng G, Zhang Z, Bardo MT, Crooks PA. Targeting reward-relevant nicotinic receptors in the discovery of novel pharmacotherapeutic agents to treat tobacco dependence. Nebr Symp Motiv. 2009; 55:31-63. PMID: 19013938.
      View in: PubMed
    200. Penthala NR, Reddy TR, Parkin S, Crooks PA. (Z)-Methyl 4-({3-[(2,5-dioxoimidazolidin-4-yl-idene)meth-yl]-1H-indol-1-yl}meth-yl)benzoate. Acta Crystallogr Sect E Struct Rep Online. 2008 Dec 10; 65(Pt 1):o62-3. PMID: 21581703.
      View in: PubMed
    201. Jenkins C, Hewamana S, Gilkes A, Neelakantan S, Crooks P, Mills K, Pepper C, Burnett A. Nuclear factor-kappaB as a potential therapeutic target for the novel cytotoxic agent LC-1 in acute myeloid leukaemia. Br J Haematol. 2008 Dec; 143(5):661-71. PMID: 19036014.
      View in: PubMed
    202. Gordon CE, Balk EM, Becker BN, Crooks PA, Jaber BL, Johnson CA, Michael MA, Pereira BJ, Uhlig K, Levin A. KDOQI US commentary on the KDIGO clinical practice guideline for the prevention, diagnosis, evaluation, and treatment of hepatitis C in CKD. Am J Kidney Dis. 2008 Nov; 52(5):811-25. PMID: 18971009.
      View in: PubMed
    203. Vartak AP, Dwoskin LP, Crooks PA. Synthesis of symmetrical 1,5-disubstituted granatanines. Tetrahedron Lett. 2008 Oct 27; 49(44):6330-6333. PMID: 23678188.
      View in: PubMed
    204. Rahman S, Neugebauer NM, Zhang Z, Crooks PA, Dwoskin LP, Bardo MT. The novel nicotinic receptor antagonist N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide decreases nicotine-induced dopamine metabolism in rat nucleus accumbens. Eur J Pharmacol. 2008 Dec 28; 601(1-3):103-5. PMID: 19000671.
      View in: PubMed
    205. Penthala NR, Reddy TR, Parkin S, Crooks PA. (Z)-4-[3-(2,5-Dioxoimidazolidin-4-ylidenemeth-yl)-1H-indol-1-ylmeth-yl]benzonitrile. Acta Crystallogr Sect E Struct Rep Online. 2008 Oct 18; 64(Pt 11):o2122. PMID: 21580984.
      View in: PubMed
    206. Malkawi AH, Al-Ghananeem AM, de Leon J, Crooks PA. Nicotine exposure can be detected in cerebrospinal fluid of active and passive smokers. J Pharm Biomed Anal. 2009 Jan 15; 49(1):129-32. PMID: 19036546.
      View in: PubMed
    207. Zheng G, Dwoskin LP, Deaciuc AG, Crooks PA. Synthesis and evaluation of a series of homologues of lobelane at the vesicular monoamine transporter-2. Bioorg Med Chem Lett. 2008 Dec 15; 18(24):6509-12. PMID: 18976906.
      View in: PubMed
    208. Reddy TR, Penthala NR, Parkin S, Crooks PA. (Z)-Methyl 4-[3-(3-oxoquinuclidin-2-yl-idenemeth-yl)-1H-indol-1-ylmeth-yl]benzoate. Acta Crystallogr Sect E Struct Rep Online. 2008 Oct 04; 64(Pt 11):o2050. PMID: 21580918.
      View in: PubMed
    209. Reddy TR, Penthala NR, Parkin S, Crooks PA. (Z)-4-[3-(3-Oxoquinuclidin-2-ylidene-meth-yl)-1H-indol-1-ylmeth-yl]benzo-nitrile. Acta Crystallogr Sect E Struct Rep Online. 2008 Oct 04; 64(Pt 11):o2049. PMID: 21580917.
      View in: PubMed
    210. Yip-Schneider MT, Wu H, Njoku V, Ralstin M, Holcomb B, Crooks PA, Neelakantan S, Sweeney CJ, Schmidt CM. Effect of celecoxib and the novel anti-cancer agent, dimethylamino-parthenolide, in a developmental model of pancreatic cancer. Pancreas. 2008 Oct; 37(3):e45-53. PMID: 18815538.
      View in: PubMed
    211. Holtman JR, Crooks PA, Johnson-Hardy JK, Hojomat M, Kleven M, Wala EP. Effects of norketamine enantiomers in rodent models of persistent pain. Pharmacol Biochem Behav. 2008 Oct; 90(4):676-85. PMID: 18586315.
      View in: PubMed
    212. Holtman JR, Crooks PA, Johnson-Hardy J, Wala EP. Interaction between morphine and norketamine enantiomers in rodent models of nociception. Pharmacol Biochem Behav. 2008 Oct; 90(4):769-77. PMID: 18582492.
      View in: PubMed
    213. Zhang Z, Zheng G, Pivavarchyk M, Deaciuc AG, Dwoskin LP, Crooks PA. Tetrakis-azaaromatic quaternary ammonium salts: novel subtype-selective antagonists at neuronal nicotinic receptors that mediate nicotine-evoked dopamine release. Bioorg Med Chem Lett. 2008 Nov 01; 18(21):5753-7. PMID: 18851914.
      View in: PubMed
    214. Zhang Z, Lockman PR, Mittapalli RK, Allen DD, Dwoskin LP, Crooks PA. bis-Pyridinium cyclophanes: novel ligands with high affinity for the blood-brain barrier choline transporter. Bioorg Med Chem Lett. 2008 Oct 15; 18(20):5622-5. PMID: 18793853.
      View in: PubMed
    215. Albayati ZA, Dwoskin LP, Crooks PA. Pharmacokinetics of the novel nicotinic receptor antagonist N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide in the rat. Drug Metab Dispos. 2008 Oct; 36(10):2024-9. PMID: 18617603.
      View in: PubMed
    216. Nasim S, Crooks PA. Antileukemic activity of aminoparthenolide analogs. Bioorg Med Chem Lett. 2008 Jul 15; 18(14):3870-3. PMID: 18590961.
      View in: PubMed
    217. Dwoskin LP, Wooters TE, Sumithran SP, Siripurapu KB, Joyce BM, Lockman PR, Manda VK, Ayers JT, Zhang Z, Deaciuc AG, McIntosh JM, Crooks PA, Bardo MT. N,N'-Alkane-diyl-bis-3-picoliniums as nicotinic receptor antagonists: inhibition of nicotine-evoked dopamine release and hyperactivity. J Pharmacol Exp Ther. 2008 Aug; 326(2):563-76. PMID: 18460644.
      View in: PubMed
    218. Malkawi AH, Al-Ghananeem AM, Crooks PA. Development of a GC-MS assay for the determination of fentanyl pharmacokinetics in rabbit plasma after sublingual spray delivery. AAPS J. 2008 Jun; 10(2):261-7. PMID: 18459057.
      View in: PubMed
    219. Banks SL, Pinninti RR, Gill HS, Crooks PA, Prausnitz MR, Stinchcomb AL. Flux across [corrected] microneedle-treated skin is increased by increasing charge of naltrexone and naltrexol in vitro. Pharm Res. 2008 Jul; 25(7):1677-85. PMID: 18449628.
      View in: PubMed
    220. Papke RL, Dwoskin LP, Crooks PA, Zheng G, Zhang Z, McIntosh JM, Stokes C. Extending the analysis of nicotinic receptor antagonists with the study of alpha6 nicotinic receptor subunit chimeras. Neuropharmacology. 2008 Jun; 54(8):1189-200. PMID: 18448138.
      View in: PubMed
    221. Bhatti BS, Strachan JP, Breining SR, Miller CH, Tahiri P, Crooks PA, Deo N, Day CS, Caldwell WS. Synthesis of 2-(pyridin-3-yl)-1-azabicyclo[3.2.2]nonane, 2-(pyridin-3-yl)-1-azabicyclo[2.2.2]octane, and 2-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, a class of potent nicotinic acetylcholine receptor-ligands. J Org Chem. 2008 May 02; 73(9):3497-507. PMID: 18363376.
      View in: PubMed
    222. Nasim S, Parkin S, Crooks PA. (11R)-13-[2-(4-Hydroxy-phen-yl)ethyl-amino]-4,5-ep-oxy-11,13-dihydro-costunolide monohydrate. Acta Crystallogr Sect E Struct Rep Online. 2008 Feb 29; 64(Pt 3):o644. PMID: 21201974.
      View in: PubMed
    223. Nasim S, Parkin S, Crooks PA. (11R,13R)-13-(Tetra-lin-1-ylamino)-4,5-ep-oxy-11,13-dihydro-costunolide. Acta Crystallogr Sect E Struct Rep Online. 2008 Feb 29; 64(Pt 3):o639. PMID: 21201970.
      View in: PubMed
    224. Kiptoo PK, Paudel KS, Hammell DC, Hamad MO, Crooks PA, Stinchcomb AL. In vivo evaluation of a transdermal codrug of 6-beta-naltrexol linked to hydroxybupropion in hairless guinea pigs. Eur J Pharm Sci. 2008 Apr 23; 33(4-5):371-9. PMID: 18321686.
      View in: PubMed
    225. Hewamana S, Alghazal S, Lin TT, Clement M, Jenkins C, Guzman ML, Jordan CT, Neelakantan S, Crooks PA, Burnett AK, Pratt G, Fegan C, Rowntree C, Brennan P, Pepper C. The NF-kappaB subunit Rel A is associated with in vitro survival and clinical disease progression in chronic lymphocytic leukemia and represents a promising therapeutic target. Blood. 2008 May 01; 111(9):4681-9. PMID: 18227347.
      View in: PubMed
    226. Sonar VN, Parkin S, Crooks PA. 3-Ethyl-2-methyl-5-methyl-ene-6,7-di-hydroindol-4(5H)-one. Acta Crystallogr Sect E Struct Rep Online. 2007 Dec 06; 64(Pt 1):o158. PMID: 21200723.
      View in: PubMed
    227. Rahman S, Zhang Z, Papke RL, Crooks PA, Dwoskin LP, Bardo MT. Region-specific effects of N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide on nicotine-induced increase in extracellular dopamine in vivo. Br J Pharmacol. 2008 Feb; 153(4):792-804. PMID: 18059317.
      View in: PubMed
    228. Sonar VN, Parkin S, Crooks PA. (Z)-3-(Benzo[b]thiophen-2-yl)-2-(3,4,5-trimethoxyphenyl)acrylonitrile and (E)-3-(benzo[b]thiophen-2-yl)-2-(3,4-dimethoxyphenyl)acrylonitrile. [corrected]. Acta Crystallogr C. 2007 Dec; 63(Pt 12):o743-5. PMID: 18057629.
      View in: PubMed
    229. Zheng G, Sumithran SP, Deaciuc AG, Dwoskin LP, Crooks PA. Tris-azaaromatic quaternary ammonium salts: Novel templates as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release. Bioorg Med Chem Lett. 2007 Dec 15; 17(24):6701-6. PMID: 17977723.
      View in: PubMed
    230. Zheng G, Zhang Z, Pivavarchyk M, Deaciuc AG, Dwoskin LP, Crooks PA. Bis-azaaromatic quaternary ammonium salts as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release: An investigation of binding conformation. Bioorg Med Chem Lett. 2007 Dec 15; 17(24):6734-8. PMID: 18029180.
      View in: PubMed
    231. Sonar VN, Thirupathi Reddy Y, Sekhar KR, Sasi S, Freeman ML, Crooks PA. Novel substituted (Z)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-one and (Z)-(+/-)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-ol derivatives as potent thermal sensitizing agents. Bioorg Med Chem Lett. 2007 Dec 15; 17(24):6821-4. PMID: 17980582.
      View in: PubMed
    232. Lockman PR, Manda VK, Geldenhuys WJ, Mittapalli RK, Thomas F, Albayati ZF, Crooks PA, Dwoskin LP, Allen DD. Carrier-mediated transport of the quaternary ammonium neuronal nicotinic receptor antagonist n,n'-dodecylbispicolinium dibromide at the blood-brain barrier. J Pharmacol Exp Ther. 2008 Jan; 324(1):244-50. PMID: 17921191.
      View in: PubMed
    233. Guzman ML, Rossi RM, Neelakantan S, Li X, Corbett CA, Hassane DC, Becker MW, Bennett JM, Sullivan E, Lachowicz JL, Vaughan A, Sweeney CJ, Matthews W, Carroll M, Liesveld JL, Crooks PA, Jordan CT. An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells. Blood. 2007 Dec 15; 110(13):4427-35. PMID: 17804695.
      View in: PubMed
    234. Sun Y, St Clair DK, Fang F, Warren GW, Rangnekar VM, Crooks PA, St Clair WH. The radiosensitization effect of parthenolide in prostate cancer cells is mediated by nuclear factor-kappaB inhibition and enhanced by the presence of PTEN. Mol Cancer Ther. 2007 Sep; 6(9):2477-86. PMID: 17876045.
      View in: PubMed
    235. Vegeler RC, Yip-Schneider MT, Ralstin M, Wu H, Crooks PA, Neelakantan S, Nakshatri H, Sweeney CJ, Schmidt CM. Effect of celecoxib and novel agent LC-1 in a hamster model of lung cancer. J Surg Res. 2007 Nov; 143(1):169-76. PMID: 17950089.
      View in: PubMed
    236. Sonar VN, Venkatraj M, Parkin S, Crooks PA. rac-(Z)-2-(2-Thienylmethylene)-1-azabicyclo[2.2.2]octan-3-ol. Acta Crystallogr C. 2007 Aug; 63(Pt 8):o493-5. PMID: 17675705.
      View in: PubMed
    237. Dwoskin LP, Joyce BM, Zheng G, Neugebauer NM, Manda VK, Lockman P, Papke RL, Bardo MT, Crooks PA. Discovery of a novel nicotinic receptor antagonist for the treatment of nicotine addiction: 1-(3-Picolinium)-12-triethylammonium-dodecane dibromide (TMPD). Biochem Pharmacol. 2007 Oct 15; 74(8):1271-82. PMID: 17727820.
      View in: PubMed
    238. Malkawi AH, Al-Ghananeem AM, Nasim S, de Leon J, Crooks PA. An HPLC method for the simultaneous determination of neurotoxic dipyridyl isomers in human plasma. J Pharm Biomed Anal. 2007 Sep 21; 45(1):120-124. PMID: 17706392.
      View in: PubMed
    239. Ring JR, Parkin S, Crooks PA. (4-Methoxy-3-nitrobenzylideneamino)guanidinium chloride. Acta Crystallogr C. 2007 Jul; 63(Pt 7):o392-4. PMID: 17609569.
      View in: PubMed
    240. Neugebauer NM, Harrod SB, Stairs DJ, Crooks PA, Dwoskin LP, Bardo MT. Lobelane decreases methamphetamine self-administration in rats. Eur J Pharmacol. 2007 Sep 24; 571(1):33-8. PMID: 17612524.
      View in: PubMed
    241. Howard-Sparks M, Al-Ghananeem AM, Crooks PA, Pearson AP. A novel chemical delivery system comprising an ocular sustained release formulation of a 3alpha, 17alpha, 21-trihydroxy-5beta-pregnan-20-one-BIS-5-fluorouracil [correction of flourouracil] codrug. Drug Dev Ind Pharm. 2007 Jun; 33(6):677-82. PMID: 17613031.
      View in: PubMed
    242. Yip-Schneider MT, Wu H, Ralstin M, Yiannoutsos C, Crooks PA, Neelakantan S, Noble S, Nakshatri H, Sweeney CJ, Schmidt CM. Suppression of pancreatic tumor growth by combination chemotherapy with sulindac and LC-1 is associated with cyclin D1 inhibition in vivo. Mol Cancer Ther. 2007 Jun; 6(6):1736-44. PMID: 17541034.
      View in: PubMed
    243. Al-Ghananeem AM, Malkawi AH, Crooks PA. Scopolamine sublingual spray: an alternative route of delivery for the treatment of motion sickness. Drug Dev Ind Pharm. 2007 May; 33(5):577-82. PMID: 17520450.
      View in: PubMed
    244. Sonar VN, Venkatraj M, Parkin S, Crooks PA. (Z)-2-[(1-Phenylsulfonyl-1H-indol-3-yl)methylene]-1-azabicyclo[2.2.2]octan-3-one semicarbazone. Acta Crystallogr C. 2007 May; 63(Pt 5):o277-9. PMID: 17478911.
      View in: PubMed
    245. Al-Ghananeem AM, Crooks PA. Phase I and phase II ocular metabolic activities and the role of metabolism in ophthalmic prodrug and codrug design and delivery. Molecules. 2007 Mar 08; 12(3):373-88. PMID: 17851396.
      View in: PubMed
    246. Middleton LS, Crooks PA, Wedlund PJ, Cass WA, Dwoskin LP. Nornicotine inhibition of dopamine transporter function in striatum via nicotinic receptor activation. Synapse. 2007 Mar; 61(3):157-65. PMID: 17146768.
      View in: PubMed
    247. Zheng F, Zheng G, Deaciuc AG, Zhan CG, Dwoskin LP, Crooks PA. Computational neural network analysis of the affinity of lobeline and tetrabenazine analogs for the vesicular monoamine transporter-2. Bioorg Med Chem. 2007 Apr 15; 15(8):2975-92. PMID: 17331733.
      View in: PubMed
    248. Al-Ghananeem AM, Albayati ZF, Malkawi A, Sonar VN, Freeman ML, Crooks PA. A pharmacokinetic study on Z-(+/-)-2-(1-benzylindole-3-yl-methylene)azabicyclo[2.2.2]octane-3-ol; a novel radio-sensitization agent. Cancer Chemother Pharmacol. 2007 Nov; 60(6):915-9. PMID: 17294191.
      View in: PubMed
    249. Sonar VN, Parkin S, Crooks PA. (Z)-2-(1-Benzyl-5-nitro-1H-indol-3-ylmethylene)-1-azabicyclo[2.2.2]octan-3-one. Acta Crystallogr C. 2007 Feb; 63(Pt 2):o135-6. PMID: 17284808.
      View in: PubMed
    250. Sekhar KR, Sonar VN, Muthusamy V, Sasi S, Laszlo A, Sawani J, Horikoshi N, Higashikubo R, Bristow RG, Borrelli MJ, Crooks PA, Lepock JR, Roti Roti JL, Freeman ML. Novel chemical enhancers of heat shock increase thermal radiosensitization through a mitotic catastrophe pathway. Cancer Res. 2007 Jan 15; 67(2):695-701. PMID: 17234780.
      View in: PubMed
    251. Papke RL, Dwoskin LP, Crooks PA. The pharmacological activity of nicotine and nornicotine on nAChRs subtypes: relevance to nicotine dependence and drug discovery. J Neurochem. 2007 Apr; 101(1):160-7. PMID: 17241116.
      View in: PubMed
    252. Huang X, Zheng F, Chen X, Crooks PA, Dwoskin LP, Zhan CG. Modeling subtype-selective agonists binding with alpha4beta2 and alpha7 nicotinic acetylcholine receptors: effects of local binding and long-range electrostatic interactions. J Med Chem. 2006 Dec 28; 49(26):7661-74. PMID: 17181149.
      View in: PubMed
    253. Chen J, Deaciuc AG, Dwoskin LP, Crooks PA, Bai D. N, N -disubstituted piperazines and homopiperazines: synthesis and affinities at alpha4beta2* and alpha7* neuronal nicotinic acetylcholine receptors. J Enzyme Inhib Med Chem. 2006 Dec; 21(6):667-80. PMID: 17252939.
      View in: PubMed
    254. Zheng G, Dwoskin LP, Crooks PA. Vesicular monoamine transporter 2: role as a novel target for drug development. AAPS J. 2006 Nov 10; 8(4):E682-92. PMID: 17233532.
      View in: PubMed
    255. Stairs DJ, Neugebauer NM, Wei X, Boustany C, Hojahmat M, Cassis LA, Crooks PA, Dwoskin LP, Bardo MT. Effects of nornicotine enantiomers on intravenous S(-)-nicotine self-administration and cardiovascular function in rats. Psychopharmacology (Berl). 2007 Feb; 190(2):145-55. PMID: 17096082.
      View in: PubMed
    256. Rahman S, Neugebauer NM, Zhang Z, Crooks PA, Dwoskin LP, Bardo MT. The effects of a novel nicotinic receptor antagonist N,N-dodecane-1,12-diyl-bis-3-picolinium dibromide (bPiDDB) on acute and repeated nicotine-induced increases in extracellular dopamine in rat nucleus accumbens. Neuropharmacology. 2007 Mar; 52(3):755-63. PMID: 17097117.
      View in: PubMed
    257. Zheng G, Horton DB, Deaciuc AG, Dwoskin LP, Crooks PA. Des-keto lobeline analogs with increased potency and selectivity at dopamine and serotonin transporters. Bioorg Med Chem Lett. 2006 Oct 01; 16(19):5018-21. PMID: 16905316.
      View in: PubMed
    258. Hamad MO, Kiptoo PK, Stinchcomb AL, Crooks PA. Synthesis and hydrolytic behavior of two novel tripartate codrugs of naltrexone and 6beta-naltrexol with hydroxybupropion as potential alcohol abuse and smoking cessation agents. Bioorg Med Chem. 2006 Oct 15; 14(20):7051-61. PMID: 16798000.
      View in: PubMed
    259. Crooks PA, Kottayil SG, Al-Ghananeem AM, Byrn SR, Butterfield DA. Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners. Bioorg Med Chem Lett. 2006 Aug 15; 16(16):4291-5. PMID: 16777416.
      View in: PubMed
    260. Kiptoo PK, Hamad MO, Crooks PA, Stinchcomb AL. Enhancement of transdermal delivery of 6-beta-naltrexol via a codrug linked to hydroxybupropion. J Control Release. 2006 Jun 28; 113(2):137-45. PMID: 16750868.
      View in: PubMed
    261. Al-Ghananeem AM, Malkawi AH, Crooks PA. Effect of pH on sublingual absorption of oxycodone hydrochloride. AAPS PharmSciTech. 2006 Mar 10; 7(1):E23. PMID: 16584154.
      View in: PubMed
    262. Sonar VN, Parkin S, Crooks PA. 1-(1H-Indol-3-ylcarbonyl)-N-(4-methoxybenzyl)formamide. Acta Crystallogr C. 2006 Mar; 62(Pt 3):o153-4. PMID: 16518054.
      View in: PubMed
    263. Chandrasekaran S, Al-Ghananeem AM, Riggs RM, Crooks PA. Synthesis and stability of two indomethacin prodrugs. Bioorg Med Chem Lett. 2006 Apr 01; 16(7):1874-9. PMID: 16439128.
      View in: PubMed
    264. Zheng F, Bayram E, Sumithran SP, Ayers JT, Zhan CG, Schmitt JD, Dwoskin LP, Crooks PA. QSAR modeling of mono- and bis-quaternary ammonium salts that act as antagonists at neuronal nicotinic acetylcholine receptors mediating dopamine release. Bioorg Med Chem. 2006 May 01; 14(9):3017-37. PMID: 16431111.
      View in: PubMed
    265. Wilkins LH, Miller DK, Ayers JT, Crooks PA, Dwoskin LP. N-n-alkylnicotinium analogs, a novel class of antagonists at alpha 4 beta 2* nicotinic acetylcholine receptors: inhibition of S(-)-nicotine-evoked 86Rb+ efflux from rat thalamic synaptosomes. AAPS J. 2006 Jan 13; 7(4):E922-30. PMID: 16594645.
      View in: PubMed
    266. Ayers JT, Xu R, Dwoskin LP, Crooks PA. A general procedure for the enantioselective synthesis of the minor tobacco alkaloids nornicotine, anabasine, and anatabine. AAPS J. 2005 Oct 31; 7(3):E752-8. PMID: 16353951.
      View in: PubMed
    267. Ayers JT, Clauset A, Schmitt JD, Dwoskin LP, Crooks PA. Molecular modeling of mono- and bis-quaternary ammonium salts as ligands at the alpha4beta2 nicotinic acetylcholine receptor subtype using nonlinear techniques. AAPS J. 2005 Oct 25; 7(3):E678-85. PMID: 16353944.
      View in: PubMed
    268. Sonar VN, Parkin S, Crooks PA. (Z)-2-(3-methoxybenzylidene)-1-azabicyclo[2.2.2]octan-3-one. Acta Crystallogr C. 2005 Nov; 61(Pt 11):o660-1. PMID: 16272604.
      View in: PubMed
    269. Huang X, Zheng F, Crooks PA, Dwoskin LP, Zhan CG. Modeling multiple species of nicotine and deschloroepibatidine interacting with alpha4beta2 nicotinic acetylcholine receptor: from microscopic binding to phenomenological binding affinity. J Am Chem Soc. 2005 Oct 19; 127(41):14401-14. PMID: 16218635.
      View in: PubMed
    270. Zheng G, Dwoskin LP, Deaciuc AG, Crooks PA. Synthesis and evaluation of a series of tropane analogues as novel vesicular monoamine transporter-2 ligands. Bioorg Med Chem Lett. 2005 Oct 15; 15(20):4463-6. PMID: 16112864.
      View in: PubMed
    271. Neugebauer NM, Zhang Z, Crooks PA, Dwoskin LP, Bardo MT. Effect of a novel nicotinic receptor antagonist, N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide, on nicotine self-administration and hyperactivity in rats. Psychopharmacology (Berl). 2006 Mar; 184(3-4):426-34. PMID: 16220336.
      View in: PubMed
    272. Howard-Sparks M, Al-Ghananeem AM, Pearson AP, Crooks PA. Evaluation of O(3alpha)-, O(21)-di-(N(1)-methyloxycarbonyl-2, 4-dioxo-5-fluoropyrimidinyl) 17alpha-hydroxy-5beta-pregnan-20-one as a novel potential antiangiogenic codrug. J Enzyme Inhib Med Chem. 2005 Oct; 20(5):417-28. PMID: 16335049.
      View in: PubMed
    273. Nalluri BN, Milligan C, Chen J, Crooks PA, Stinchcomb AL. In vitro release studies on matrix type transdermal drug delivery systems of naltrexone and its acetyl prodrug. Drug Dev Ind Pharm. 2005 Oct; 31(9):871-7. PMID: 16305998.
      View in: PubMed
    274. Wei X, Sumithran SP, Deaciuc AG, Burton HR, Bush LP, Dwoskin LP, Crooks PA. Identification and synthesis of novel alkaloids from the root system of Nicotiana tabacum: affinity for neuronal nicotinic acetylcholine receptors. Life Sci. 2005 Dec 22; 78(5):495-505. PMID: 16197964.
      View in: PubMed
    275. Papke RL, Zheng G, Horenstein NA, Dwoskin LP, Crooks PA. The characterization of a novel rigid nicotine analog with alpha7-selective nAChR agonist activity and modulation of agonist properties by boron inclusion. Bioorg Med Chem Lett. 2005 Sep 01; 15(17):3874-80. PMID: 16005216.
      View in: PubMed
    276. Paudel KS, Nalluri BN, Hammell DC, Valiveti S, Kiptoo P, Hamad MO, Crooks PA, Stinchcomb AL. Transdermal delivery of naltrexone and its active metabolite 6-beta-naltrexol in human skin in vitro and guinea pigs in vivo. J Pharm Sci. 2005 Sep; 94(9):1965-75. PMID: 16052561.
      View in: PubMed
    277. Sumithran SP, Crooks PA, Xu R, Zhu J, Deaciuc AG, Wilkins LH, Dwoskin LP. Introduction of unsaturation into the N-n-alkyl chain of the nicotinic receptor antagonists, NONI and NDNI: effect on affinity and selectivity. AAPS J. 2005 Aug 29; 7(1):E201-17. PMID: 16146341.
      View in: PubMed
    278. Zheng G, Dwoskin LP, Deaciuc AG, Norrholm SD, Crooks PA. Defunctionalized lobeline analogues: structure-activity of novel ligands for the vesicular monoamine transporter. J Med Chem. 2005 Aug 25; 48(17):5551-60. PMID: 16107155.
      View in: PubMed
    279. Cynkowska G, Cynkowski T, Al-Ghananeem AM, Al-Ghananeem AA, Guo H, Ashton P, Crooks PA. Novel antiglaucoma prodrugs and codrugs of ethacrynic acid. Bioorg Med Chem Lett. 2005 Aug 01; 15(15):3524-7. PMID: 15990301.
      View in: PubMed
    280. Sonar VN, Parkin S, Crooks PA. (E)-2-Methyl-3-(2-methyl-2-nitrovinyl)-1H-indole and (E)-3-(2-methyl-2-nitrovinyl)-2-phenyl-1H-indole. Acta Crystallogr C. 2005 Aug; 61(Pt 8):o527-30. PMID: 16082109.
      View in: PubMed
    281. Geldenhuys WJ, Lockman PR, Nguyen TH, Van der Schyf CJ, Crooks PA, Dwoskin LP, Allen DD. 3D-QSAR study of bis-azaaromatic quaternary ammonium analogs at the blood-brain barrier choline transporter. Bioorg Med Chem. 2005 Jul 01; 13(13):4253-61. PMID: 15878282.
      View in: PubMed
    282. Valiveti S, Paudel KS, Hammell DC, Hamad MO, Chen J, Crooks PA, Stinchcomb AL. In vitro/in vivo correlation of transdermal naltrexone prodrugs in hairless guinea pigs. Pharm Res. 2005 Jun; 22(6):981-9. PMID: 15948042.
      View in: PubMed
    283. Zheng G, Dwoskin LP, Deaciuc AG, Zhu J, Jones MD, Crooks PA. Lobelane analogues as novel ligands for the vesicular monoamine transporter-2. Bioorg Med Chem. 2005 Jun 02; 13(12):3899-909. PMID: 15911306.
      View in: PubMed
    284. Vaddi HK, Hamad MO, Chen J, Banks SL, Crooks PA, Stinchcomb AL. Human skin permeation of branched-chain 3-0-alkyl ester and carbonate prodrugs of naltrexone. Pharm Res. 2005 May; 22(5):758-65. PMID: 15906171.
      View in: PubMed
    285. Hammell DC, Stolarczyk EI, Klausner M, Hamad MO, Crooks PA, Stinchcomb AL. Bioconversion of naltrexone and its 3-O-alkyl-ester prodrugs in a human skin equivalent. J Pharm Sci. 2005 Apr; 94(4):828-36. PMID: 15736197.
      View in: PubMed
    286. Valiveti S, Hammell DC, Paudel KS, Hamad MO, Crooks PA, Stinchcomb AL. In vivo evaluation of 3-O-alkyl ester transdermal prodrugs of naltrexone in hairless guinea pigs. J Control Release. 2005 Feb 02; 102(2):509-20. PMID: 15653167.
      View in: PubMed
    287. Sonar VN, Parkin S, Crooks PA. (Z)-3-(1H-Indol-3-yl)-2-(3-thienyl)acrylonitrile and (Z)-3-[1-(4-tert-butylbenzyl)-1H-indol-3-yl]-2-(3-thienyl)acrylonitrile. Acta Crystallogr C. 2005 Feb; 61(Pt 2):o78-80. PMID: 15695916.
      View in: PubMed
    288. Zheng G, Dwoskin LP, Crooks PA. Indirect trapping of the retroconjugate addition reaction intermediate involved in the epimerization of lobeline: application to the synthesis of (-)-sedamine. J Org Chem. 2004 Nov 26; 69(24):8514-7. PMID: 15549833.
      View in: PubMed
    289. Li S, Crooks PA, Wei X, de Leon J. Toxicity of dipyridyl compounds and related compounds. Crit Rev Toxicol. 2004 Sep-Oct; 34(5):447-60. PMID: 15560568.
      View in: PubMed
    290. Sonar VN, Parkin S, Crooks PA. (Z)-2-(1-Phenylsulfonyl-1H-indol-3-ylmethylene)-1-azabicyclo[2.2.2]octan-3-one and (Z)-(S)-2-(1-phenylsulfonyl-1H-indol-3-ylmethylene)-1-azabicyclo[2.2.2]octan-3-ol. Acta Crystallogr C. 2004 Sep; 60(Pt 9):o659-61. PMID: 15345848.
      View in: PubMed
    291. Sonar VN, Parkin S, Crooks PA. 1-(2,5-Dichlorophenyl)-3-methyl-5-phenyl-1H-pyrazole. Acta Crystallogr C. 2004 Aug; 60(Pt 8):o547-9. PMID: 15295183.
      View in: PubMed
    292. Sonar VN, Parkin S, Crooks PA. (E)-N-[(Benzo[b]thiophen-3-yl)methylene]-N'-(2,5-dichlorophenyl)hydrazine. Acta Crystallogr C. 2004 Aug; 60(Pt 8):o550-1. PMID: 15295184.
      View in: PubMed
    293. Pillai O, Hamad MO, Crooks PA, Stinchcomb AL. Physicochemical evaluation, in vitro human skin diffusion, and concurrent biotransformation of 3-O-alkyl carbonate prodrugs of naltrexone. Pharm Res. 2004 Jul; 21(7):1146-52. PMID: 15290853.
      View in: PubMed
    294. Hammell DC, Hamad M, Vaddi HK, Crooks PA, Stinchcomb AL. A duplex "Gemini" prodrug of naltrexone for transdermal delivery. J Control Release. 2004 Jun 18; 97(2):283-90. PMID: 15196755.
      View in: PubMed
    295. Miller DK, Crooks PA, Zheng G, Grinevich VP, Norrholm SD, Dwoskin LP. Lobeline analogs with enhanced affinity and selectivity for plasmalemma and vesicular monoamine transporters. J Pharmacol Exp Ther. 2004 Sep; 310(3):1035-45. PMID: 15121762.
      View in: PubMed
    296. Crooks PA, Ayers JT, Xu R, Sumithran SP, Grinevich VP, Wilkins LH, Deaciuc AG, Allen DD, Dwoskin LP. Development of subtype-selective ligands as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release. Bioorg Med Chem Lett. 2004 Apr 19; 14(8):1869-74. PMID: 15050618.
      View in: PubMed
    297. Dwoskin LP, Sumithran SP, Zhu J, Deaciuc AG, Ayers JT, Crooks PA. Subtype-selective nicotinic receptor antagonists: potential as tobacco use cessation agents. Bioorg Med Chem Lett. 2004 Apr 19; 14(8):1863-7. PMID: 15050617.
      View in: PubMed
    298. Gali-Muhtasib HU, Abou Kheir WG, Kheir LA, Darwiche N, Crooks PA. Molecular pathway for thymoquinone-induced cell-cycle arrest and apoptosis in neoplastic keratinocytes. Anticancer Drugs. 2004 Apr; 15(4):389-99. PMID: 15057144.
      View in: PubMed
    299. Sonar VN, Parkin S, Crooks PA. (Z)-3-(1-Methyl-1H-indol-3-yl)-2-(thiophen-3-yl)acrylonitrile. Acta Crystallogr C. 2004 Mar; 60(Pt 3):o217-8. PMID: 15004388.
      View in: PubMed
    300. Balbo PB, Patel CN, Sell KG, Adcock RS, Neelakantan S, Crooks PA, Oliveira MA. Spectrophotometric and steady-state kinetic analysis of the biosynthetic arginine decarboxylase of Yersinia pestis utilizing arginine analogues as inhibitors and alternative substrates. Biochemistry. 2003 Dec 30; 42(51):15189-96. PMID: 14690429.
      View in: PubMed
    301. Sonar VN, Parkin S, Crooks PA. (Z)-2-(1H-Indol-3-ylmethylene)-1-azabicyclo[2.2.2]octan-3-one. Acta Crystallogr C. 2004 Jan; 60(Pt 1):o6-8. PMID: 14712032.
      View in: PubMed
    302. Zheng G, Parkin S, Dwoskin LP, Crooks PA. Two isomers of 2,4-dibenzyl-8-azabicyclo[3.2.1]octan-3-ol. Acta Crystallogr C. 2004 Jan; 60(Pt 1):o9-11. PMID: 14712033.
      View in: PubMed
    303. Sonar VN, Parkin S, Crooks PA. (Z)-2-(3-hydroxy-4-methoxybenzylidene)-1-azabicyclo[2.2.2]octan-3-one. Acta Crystallogr C. 2003 Nov; 59(Pt 11):o647-9. PMID: 14605418.
      View in: PubMed
    304. Bence AK, Crooks PA. The mechanism of L-canavanine cytotoxicity: arginyl tRNA synthetase as a novel target for anticancer drug discovery. J Enzyme Inhib Med Chem. 2003 Oct; 18(5):383-94. PMID: 14692504.
      View in: PubMed
    305. Sekhar KR, Crooks PA, Sonar VN, Friedman DB, Chan JY, Meredith MJ, Starnes JH, Kelton KR, Summar SR, Sasi S, Freeman ML. NADPH oxidase activity is essential for Keap1/Nrf2-mediated induction of GCLC in response to 2-indol-3-yl-methylenequinuclidin-3-ols. Cancer Res. 2003 Sep 01; 63(17):5636-45. PMID: 14500406.
      View in: PubMed
    306. Grinevich VP, Crooks PA, Sumithran SP, Haubner AJ, Ayers JT, Dwoskin LP. N-n-alkylpyridinium analogs, a novel class of nicotinic receptor antagonists: selective inhibition of nicotine-evoked [3H] dopamine overflow from superfused rat striatal slices. J Pharmacol Exp Ther. 2003 Sep; 306(3):1011-20. PMID: 12766255.
      View in: PubMed
    307. de Leon J, Diaz FJ, Rogers T, Browne D, Dinsmore L, Ghosheh OA, Dwoskin LP, Crooks PA. Plasma cotinine, 3'-hydroxycotinine, and their glucuronides in white and black smokers. J Clin Psychopharmacol. 2003 Apr; 23(2):209-11. PMID: 12640226.
      View in: PubMed
    308. Allen DD, Lockman PR, Roder KE, Dwoskin LP, Crooks PA. Active transport of high-affinity choline and nicotine analogs into the central nervous system by the blood-brain barrier choline transporter. J Pharmacol Exp Ther. 2003 Mar; 304(3):1268-74. PMID: 12604705.
      View in: PubMed
    309. Bence AK, Adams VR, Crooks PA. L-Canavanine as a radiosensitization agent for human pancreatic cancer cells. Mol Cell Biochem. 2003 Feb; 244(1-2):37-43. PMID: 12701807.
      View in: PubMed
    310. de Leon J, Diaz FJ, Rogers T, Browne D, Dinsmore L, Ghosheh OH, Dwoskin LP, Crooks PA. A pilot study of plasma caffeine concentrations in a US sample of smoker and nonsmoker volunteers. Prog Neuropsychopharmacol Biol Psychiatry. 2003 Feb; 27(1):165-71. PMID: 12551740.
      View in: PubMed
    311. Bence AK, Worthen DR, Stables JP, Crooks PA. An in vivo evaluation of the antiseizure activity and acute neurotoxicity of agmatine. Pharmacol Biochem Behav. 2003 Feb; 74(3):771-5. PMID: 12543244.
      View in: PubMed
    312. Chen J, Norrholm S, Dwoskin LP, Crooks PA, Bai D. N,N-disubstituted piperazines: synthesis and affinities at alpha4beta2(*) and alpha7(*) neuronal nicotinic acetylcholine receptors. Bioorg Med Chem Lett. 2003 Jan 06; 13(1):97-100. PMID: 12467625.
      View in: PubMed
    313. Wilkins LH, Grinevich VP, Ayers JT, Crooks PA, Dwoskin LP. N-n-alkylnicotinium analogs, a novel class of nicotinic receptor antagonists: interaction with alpha4beta2* and alpha7* neuronal nicotinic receptors. J Pharmacol Exp Ther. 2003 Jan; 304(1):400-10. PMID: 12490617.
      View in: PubMed
    314. Ayers JT, Dwoskin LP, Deaciuc AG, Grinevich VP, Zhu J, Crooks PA. bis-Azaaromatic quaternary ammonium analogues: ligands for alpha4beta2* and alpha7* subtypes of neuronal nicotinic receptors. Bioorg Med Chem Lett. 2002 Nov 04; 12(21):3067-71. PMID: 12372503.
      View in: PubMed
    315. Ring JR, Haubner AJ, Crooks PA. Novel antiepileptic and anticonvulsive therapeutic agents. IDrugs. 2002 Oct; 5(10):990-9. PMID: 12800062.
      View in: PubMed
    316. de Leon J, Diaz FJ, Rogers T, Browne D, Dinsmore L, Ghosheh OH, Dwoskin LP, Crooks PA. Total cotinine in plasma: a stable biomarker for exposure to tobacco smoke. J Clin Psychopharmacol. 2002 Oct; 22(5):496-501. PMID: 12352273.
      View in: PubMed
    317. Wilkins LH, Haubner A, Ayers JT, Crooks PA, Dwoskin LP. N-n-alkylnicotinium analogs, a novel class of nicotinic receptor antagonist: inhibition of S(-)-nicotine-evoked [(3)H]dopamine overflow from superfused rat striatal slices. J Pharmacol Exp Ther. 2002 Jun; 301(3):1088-96. PMID: 12023541.
      View in: PubMed
    318. Bence AK, Worthen DR, Adams VR, Crooks PA. The antiproliferative and immunotoxic effects of L-canavanine and L-canaline. Anticancer Drugs. 2002 Mar; 13(3):313-20. PMID: 11984075.
      View in: PubMed
    319. Dwoskin LP, Crooks PA. A novel mechanism of action and potential use for lobeline as a treatment for psychostimulant abuse. Biochem Pharmacol. 2002 Jan 15; 63(2):89-98. PMID: 11841781.
      View in: PubMed
    320. Green TA, Crooks PA, Bardo MT, Dwoskin LP. Contributory role for nornicotine in nicotine neuropharmacology: nornicotine-evoked [3H]dopamine overflow from rat nucleus accumbens slices. Biochem Pharmacol. 2001 Dec 15; 62(12):1597-603. PMID: 11755112.
      View in: PubMed
    321. Truong A, Xing X, Forsayeth JR, Dwoskin LP, Crooks PA, Cohen BN. Pharmacological differences between immunoisolated native brain and heterologously expressed rat alpha4beta2 nicotinic receptors. Brain Res Mol Brain Res. 2001 Nov 30; 96(1-2):68-76. PMID: 11731010.
      View in: PubMed
    322. Dwoskin LP, Teng LH, Crooks PA. Nornicotine, a nicotine metabolite and tobacco alkaloid: desensitization of nicotinic receptor-stimulated dopamine release from rat striatum. Eur J Pharmacol. 2001 Sep 28; 428(1):69-79. PMID: 11779039.
      View in: PubMed
    323. Dwoskin LP, Crooks PA. Competitive neuronal nicotinic receptor antagonists: a new direction for drug discovery. J Pharmacol Exp Ther. 2001 Aug; 298(2):395-402. PMID: 11454899.
      View in: PubMed
    324. Miller DK, Wilkins LH, Bardo MT, Crooks PA, Dwoskin LP. Once weekly administration of nicotine produces long-lasting locomotor sensitization in rats via a nicotinic receptor-mediated mechanism. Psychopharmacology (Berl). 2001 Aug; 156(4):469-76. PMID: 11498725.
      View in: PubMed
    325. Harrod SB, Dwoskin LP, Crooks PA, Klebaur JE, Bardo MT. Lobeline attenuates d-methamphetamine self-administration in rats. J Pharmacol Exp Ther. 2001 Jul; 298(1):172-9. PMID: 11408539.
      View in: PubMed
    326. Xu R, Dwoskin LP, Grinevich VP, Deaciuc G, Crooks PA. Neuronal nicotinic acetylcholine receptor binding affinities of boron-containing nicotine analogues. Bioorg Med Chem Lett. 2001 May 07; 11(9):1245-8. PMID: 11354387.
      View in: PubMed
    327. Ghosheh OA, Dwoskin LP, Miller DK, Crooks PA. Accumulation of nicotine and its metabolites in rat brain after intermittent or continuous peripheral administration of [2'-(14)C]nicotine. Drug Metab Dispos. 2001 May; 29(5):645-51. PMID: 11302929.
      View in: PubMed
    328. Miller DK, Crooks PA, Teng L, Witkin JM, Munzar P, Goldberg SR, Acri JB, Dwoskin LP. Lobeline inhibits the neurochemical and behavioral effects of amphetamine. J Pharmacol Exp Ther. 2001 Mar; 296(3):1023-34. PMID: 11181937.
      View in: PubMed
    329. Worthen DR, Gibson DA, Rogers DT, Bence AK, Fu M, Littleton JM, Crooks PA. Endogenous indoles as novel polyamine site ligands at the N-methyl-D-aspartate receptor complex. Brain Res. 2001 Feb 02; 890(2):343-6. PMID: 11164802.
      View in: PubMed
    330. Bence AK, Rogers DT, Worthen DR, Fu M, Littleton JM, Crooks PA. Aminoanthraquinones as novel ligands at the polyamine binding site on the N-methyl-D-aspartate receptor complex. Bioorg Med Chem Lett. 2000 Dec 04; 10(23):2621-3. PMID: 11128637.
      View in: PubMed
    331. Miller DK, Crooks PA, Dwoskin LP. Lobeline inhibits nicotine-evoked [(3)H]dopamine overflow from rat striatal slices and nicotine-evoked (86)Rb(+) efflux from thalamic synaptosomes. Neuropharmacology. 2000 Oct; 39(13):2654-62. PMID: 11044735.
      View in: PubMed
    332. Green TA, Phillips SB, Crooks PA, Dwoskin LP, Bardo MT. Nornicotine pretreatment decreases intravenous nicotine self-administration in rats. Psychopharmacology (Berl). 2000 Oct; 152(3):289-94. PMID: 11105939.
      View in: PubMed
    333. Hussain AA, Jona J, Crooks PA. Competitive inhibitory effect of external nucleophile concentration on intramolecular O- to N-acylation in O-acetylsalicylamide. AAPS PharmSciTech. 2000 Aug 19; 1(3):E-TN1. PMID: 14727901.
      View in: PubMed
    334. Ghosheh OA, Browne D, Rogers T, de Leon J, Dwoskin LP, Crooks PA. A simple high performance liquid chromatographic method for the quantification of total cotinine, total 3'-hydroxycotinine and caffeine in the plasma of smokers. J Pharm Biomed Anal. 2000 Aug 15; 23(2-3):543-9. PMID: 10933548.
      View in: PubMed
    335. Ghosheh O, Dwoskin LP, Li WK, Crooks PA. Residence times and half-lives of nicotine metabolites in rat brain after acute peripheral administration of [2'-(14)C]nicotine. Drug Metab Dispos. 1999 Dec; 27(12):1448-55. PMID: 10570026.
      View in: PubMed
    336. Shafaee N, Houng M, Truong A, Viseshakul N, Figl A, Sandhu S, Forsayeth JR, Dwoskin LP, Crooks PA, Cohen BN. Pharmacological similarities between native brain and heterologously expressed alpha4beta2 nicotinic receptors. Br J Pharmacol. 1999 Nov; 128(6):1291-9. PMID: 10578144.
      View in: PubMed
    337. Bardo MT, Green TA, Crooks PA, Dwoskin LP. Nornicotine is self-administered intravenously by rats. Psychopharmacology (Berl). 1999 Oct; 146(3):290-6. PMID: 10541729.
      View in: PubMed
    338. Dwoskin LP, Crooks PA, Teng L, Green TA, Bardo MT. Acute and chronic effects of nornicotine on locomotor activity in rats: altered response to nicotine. Psychopharmacology (Berl). 1999 Aug; 145(4):442-51. PMID: 10460322.
      View in: PubMed
    339. Dwoskin LP, Wilkins LH, Pauly JR, Crooks PA. Development of a novel class of subtype-selective nicotinic receptor antagonist: pyridine-N-substituted nicotine analogs. Ann N Y Acad Sci. 1999 Apr 30; 868:617-9. PMID: 10414342.
      View in: PubMed
    340. Ghosheh OA, Houdi AA, Crooks PA. High performance liquid chromatographic analysis of the pharmacologically active quinones and related compounds in the oil of the black seed (Nigella sativa L.). J Pharm Biomed Anal. 1999 Apr; 19(5):757-62. PMID: 10698539.
      View in: PubMed
    341. Dwoskin LP, Teng L, Buxton ST, Crooks PA. (S)-(-)-Cotinine, the major brain metabolite of nicotine, stimulates nicotinic receptors to evoke [3H]dopamine release from rat striatal slices in a calcium-dependent manner. J Pharmacol Exp Ther. 1999 Mar; 288(3):905-11. PMID: 10027825.
      View in: PubMed
    342. Swango JH, Bhatti BS, Qureshi MM, Crooks PA. A novel enantioselective synthesis of (S)-(-)- and (R)-(+)-nornicotine via alkylation of a chiral 2-hydroxy-3-pinanone ketimine template. Chirality. 1999; 11(4):316-8. PMID: 10224659.
      View in: PubMed
    343. Worthen DR, Chien L, Tsuboi CP, Mu XY, Bartik MM, Crooks PA. L-Canavanine modulates cellular growth, chemosensitivity and P-glycoprotein substrate accumulation in cultured human tumor cell lines. Cancer Lett. 1998 Oct 23; 132(1-2):229-39. PMID: 10397478.
      View in: PubMed
    344. Howard M, Sen HA, Capoor S, Herfel R, Crooks PA, Jacobson MK. Measurement of adenosine concentration in aqueous and vitreous. Invest Ophthalmol Vis Sci. 1998 Sep; 39(10):1942-6. PMID: 9727417.
      View in: PubMed
    345. Aziz SM, Worthen DR, Yatin M, Ain KB, Crooks PA. A unique interaction between polyamine and multidrug resistance (P-glycoprotein) transporters in cultured Chinese hamster ovary cells transfected with mouse mdr-1 gene. Biochem Pharmacol. 1998 Jul 15; 56(2):181-7. PMID: 9698071.
      View in: PubMed
    346. Teng L, Crooks PA, Dwoskin LP. Lobeline displaces [3H]dihydrotetrabenazine binding and releases [3H]dopamine from rat striatal synaptic vesicles: comparison with d-amphetamine. J Neurochem. 1998 Jul; 71(1):258-65. PMID: 9648873.
      View in: PubMed
    347. Worthen DR, Ghosheh OA, Crooks PA. The in vitro anti-tumor activity of some crude and purified components of blackseed, Nigella sativa L. Anticancer Res. 1998 May-Jun; 18(3A):1527-32. PMID: 9673365.
      View in: PubMed
    348. Bencherif M, Schmitt JD, Bhatti BS, Crooks P, Caldwell WS, Lovette ME, Fowler K, Reeves L, Lippiello PM. The heterocyclic substituted pyridine derivative (+/-)-2-(-3-pyridinyl)-1-azabicyclo[2.2.2]octane (RJR-2429): a selective ligand at nicotinic acetylcholine receptors. J Pharmacol Exp Ther. 1998 Mar; 284(3):886-94. PMID: 9495846.
      View in: PubMed
    349. Bardo MT, Bevins RA, Klebaur JE, Crooks PA, Dwoskin LP. (-)-Nornicotine partially substitutes for (+)-amphetamine in a drug discrimination paradigm in rats. Pharmacol Biochem Behav. 1997 Dec; 58(4):1083-7. PMID: 9408217.
      View in: PubMed
    350. Teng L, Crooks PA, Buxton ST, Dwoskin LP. Nicotinic-receptor mediation of S(-)nornicotine-evoked -3H-overflow from rat striatal slices preloaded with -3H-dopamine. J Pharmacol Exp Ther. 1997 Nov; 283(2):778-87. PMID: 9353398.
      View in: PubMed
    351. Crooks PA, Dwoskin LP. Contribution of CNS nicotine metabolites to the neuropharmacological effects of nicotine and tobacco smoking. Biochem Pharmacol. 1997 Oct 01; 54(7):743-53. PMID: 9353128.
      View in: PubMed
    352. Teng L, Crooks PA, Sonsalla PK, Dwoskin LP. Lobeline and nicotine evoke [3H]overflow from rat striatal slices preloaded with [3H]dopamine: differential inhibition of synaptosomal and vesicular [3H]dopamine uptake. J Pharmacol Exp Ther. 1997 Mar; 280(3):1432-44. PMID: 9067333.
      View in: PubMed
    353. Crooks PA, Li M, Dwoskin LP. Metabolites of nicotine in rat brain after peripheral nicotine administration. Cotinine, nornicotine, and norcotinine. Drug Metab Dispos. 1997 Jan; 25(1):47-54. PMID: 9010629.
      View in: PubMed
    354. Worthen DR, Ratliff DK, Rosenthal GA, Trifonov L, Crooks PA. Structure-activity studies of L-canaline-mediated inhibition of porcine alanine aminotransferase. Chem Res Toxicol. 1996 Dec; 9(8):1293-7. PMID: 8951231.
      View in: PubMed
    355. Aziz SM, Gillespie MN, Crooks PA, Tofiq SF, Tsuboi CP, Olson JW, Gosland MP. The potential of a novel polyamine transport inhibitor in cancer chemotherapy. J Pharmacol Exp Ther. 1996 Jul; 278(1):185-92. PMID: 8764350.
      View in: PubMed
    356. Houdi AA, Kottayil S, Crooks PA, Butterfield DA. 3-O-acetylmorphine-6-O-sulfate: a potent, centrally acting morphine derivative. Pharmacol Biochem Behav. 1996 Mar; 53(3):665-71. PMID: 8866970.
      View in: PubMed
    357. Gosland MP, Gillespie MN, Tsuboi CP, Tofiq S, Olson JW, Crooks PA, Aziz SM. Reversal of doxorubicin, etoposide, vinblastine, and taxol resistance in multidrug resistant human sarcoma cells by a polymer of spermine. Cancer Chemother Pharmacol. 1996; 37(6):593-600. PMID: 8612315.
      View in: PubMed
    358. Crooks PA, Li M, Dwoskin LP. Determination of nicotine metabolites in rat brain after peripheral radiolabeled nicotine administration: detection of nornicotine. Drug Metab Dispos. 1995 Oct; 23(10):1175-7. PMID: 8654207.
      View in: PubMed
    359. Swaffar DS, Ang CY, Desai PB, Rosenthal GA, Thomas DA, Crooks PA, John WJ. Combination therapy with 5-fluorouracil and L-canavanine: in vitro and in vivo studies. Anticancer Drugs. 1995 Aug; 6(4):586-93. PMID: 7579563.
      View in: PubMed
    360. Aziz SM, Gosland MP, Crooks PA, Olson JW, Gillespie MN. A novel polymeric spermine conjugate inhibits polyamine transport in pulmonary artery smooth muscle cells. J Pharmacol Exp Ther. 1995 Jul; 274(1):181-6. PMID: 7616397.
      View in: PubMed
    361. Dwoskin LP, Teng L, Buxton ST, Ravard A, Deo N, Crooks PA. Minor alkaloids of tobacco release [3H]dopamine from superfused rat striatal slices. Eur J Pharmacol. 1995 Mar 24; 276(1-2):195-9. PMID: 7781690.
      View in: PubMed
    362. Hussain AA, Awad R, Crooks PA, Dittert LW. Chloramine-T in radiolabeling techniques. I. Kinetics and mechanism of the reaction between chloramine-T and amino acids. Anal Biochem. 1993 Nov 01; 214(2):495-9. PMID: 8109739.
      View in: PubMed
    363. Gogineni PV, Crooks PA, Murty RB. Gas chromatographic determination of residual levels of tert.-butanol from lyophilized liposomal formulations. J Chromatogr. 1993 Oct 22; 620(1):83-8. PMID: 8106595.
      View in: PubMed
    364. Dwoskin LP, Buxton ST, Jewell AL, Crooks PA. S(-)-nornicotine increases dopamine release in a calcium-dependent manner from superfused rat striatal slices. J Neurochem. 1993 Jun; 60(6):2167-74. PMID: 8492124.
      View in: PubMed
    365. Allen DD, Crooks PA, Yokel RA. 4-Trimethylammonium antipyrine: a quaternary ammonium nonradionuclide marker for blood-brain barrier integrity during in vivo microdialysis. J Pharmacol Toxicol Methods. 1992 Nov; 28(3):129-35. PMID: 1489983.
      View in: PubMed
    366. Dannan H, Hussain A, Crooks PA, Dittert LW. Structure-activity considerations in kinetics and mechanism of chlorine exchange between chloramine-T and secondary amines. J Pharm Sci. 1992 Jul; 81(7):657-60. PMID: 1403699.
      View in: PubMed
    367. Dannan H, Crooks PA, Dittert LW, Hussain A. Kinetics and mechanism of chlorine exchange between chloramine-T and secondary amines. J Pharm Sci. 1992 Jul; 81(7):652-6. PMID: 1403698.
      View in: PubMed
    368. Caldwell WS, Greene JM, Byrd GD, Chang KM, Uhrig MS, deBethizy JD, Crooks PA, Bhatti BS, Riggs RM. Characterization of the glucuronide conjugate of cotinine: a previously unidentified major metabolite of nicotine in smokers' urine. Chem Res Toxicol. 1992 Mar-Apr; 5(2):280-5. PMID: 1643259.
      View in: PubMed
    369. Dwoskin LP, Leibee LL, Jewell AL, Fang ZX, Crooks PA. Inhibition of [3H]dopamine uptake into rat striatal slices by quaternary N-methylated nicotine metabolites. Life Sci. 1992; 50(25):PL233-7. PMID: 1593921.
      View in: PubMed
    370. Awad R, Hussain A, Crooks PA. Kinetics and mechanism of decomposition of N-chloroamino acids. II: conformationally restricted models. J Pharm Sci. 1990 Dec; 79(12):1121-2. PMID: 2079660.
      View in: PubMed
    371. Tawfig FA, Dittert L, Hussain A, Crooks PA. Rearrangement of O-acylsalicylamides via intramolecular O-to-N transacylation: rate enhancement by an adjacent carboxylic acid group. J Pharm Sci. 1990 Jul; 79(7):651. PMID: 2398477.
      View in: PubMed
    372. Bawarshi-Nassar RN, Hussain AA, Crooks PA. Nasal absorption and metabolism of progesterone and 17 beta-estradiol in the rat. Drug Metab Dispos. 1989 May-Jun; 17(3):248-54. PMID: 2568904.
      View in: PubMed
    373. Godin CS, Crooks PA. N-methylation as a toxication route for xenobiotics. II. In vivo formation of N,N'-dimethyl-4,4'-bipyridyl ion (paraquat) from 4,4'-bipyridyl in the guinea pig. Drug Metab Dispos. 1989 Mar-Apr; 17(2):180-5. PMID: 2565208.
      View in: PubMed
    374. Bawarshi-Nassar RN, Hussain A, Crooks PA. Nasal absorption of 17 alpha-ethinyloestradiol in the rat. J Pharm Pharmacol. 1989 Mar; 41(3):214-5. PMID: 2568456.
      View in: PubMed
    375. Crooks PA, Hassan SF, Benghiat E, Hemrick-Luecke SK, Fuller RW. 5'-thioadenosine derivatives as potent and selective inhibitors of histamine N-methyltransferase. Drug Metabol Drug Interact. 1989; 7(2-3):111-41. PMID: 2630176.
      View in: PubMed
    376. Nwosu CG, Crooks PA. Species variation and stereoselectivity in the metabolism of nicotine enantiomers. Xenobiotica. 1988 Dec; 18(12):1361-72. PMID: 3245230.
      View in: PubMed
    377. Nwosu CG, Godin CS, Houdi AA, Damani LA, Crooks PA. Enantioselective metabolism during continuous administration of S-(-)- and R-(+)-nicotine isomers to guinea-pigs. J Pharm Pharmacol. 1988 Dec; 40(12):862-9. PMID: 2907579.
      View in: PubMed
    378. Houdi AA, Godin CS, Crooks PA. Effect of continuous administration of nicotine on urinary histamine and N tau-methylhistamine levels in the guinea pig. Toxicol Lett. 1988 Nov; 44(1-2):161-6. PMID: 3188074.
      View in: PubMed
    379. Pool WF, Crooks PA. Biotransformation of primary nicotine metabolites: metabolism of R-(+)-[3H-N'-CH3; 14C-N-CH3] N-methylnicotinium acetate--the use of double isotope studies to determine the in-vivo stability of the N-methyl groups of N-methylnicotinium ion. J Pharm Pharmacol. 1988 Nov; 40(11):758-62. PMID: 2907553.
      View in: PubMed
    380. Damani LA, Pool WF, Crooks PA, Kaderlik RK, Ziegler DM. Stereoselectivity in the N'-oxidation of nicotine isomers by flavin-containing monooxygenase. Mol Pharmacol. 1988 Jun; 33(6):702-5. PMID: 3380084.
      View in: PubMed
    381. Crooks PA, Godin CS, Damani LA, Ansher SS, Jakoby WB. Formation of quaternary amines by N-methylation of azaheterocycles with homogeneous amine N-methyltransferases. Biochem Pharmacol. 1988 May 01; 37(9):1673-7. PMID: 3377829.
      View in: PubMed
    382. Crooks PA, Godin CS. N-methylation of nicotine enantiomers by human liver cytosol. J Pharm Pharmacol. 1988 Feb; 40(2):153-4. PMID: 2897456.
      View in: PubMed
    383. Cundy KC, Crooks PA. Biotransformation of primary nicotine metabolites. II. Metabolism of [3H]-S-(-)-cotinine in the guinea pig: determination of in vivo urinary metabolites by high-performance liquid-radiochromatography. Xenobiotica. 1987 Jul; 17(7):785-92. PMID: 3660848.
      View in: PubMed
    384. Houdi AA, Crooks PA, Van Loon GR, Schubert CA. A simple and sensitive determination of histamine and N tau-methylhistamine in biological fluids by high-performance liquid chromatography with electrochemical detection. J Pharm Sci. 1987 May; 76(5):398-401. PMID: 3656102.
      View in: PubMed
    385. Godin CS, Crooks PA, Damani LA. N-methylation of phenylpyridines and bispyridyls as a potential toxication route: tissue distribution of azaheterocycle N-methyltransferase activity in the rabbit. Toxicol Lett. 1986 Dec; 34(2-3):217-22. PMID: 3798480.
      View in: PubMed
    386. Crooks PA, Burn P, Sewell RD, Upton N. Synthesis and antinociceptive properties of a series of exo- and endo-6-hydroxy-2-aminobenzonorbornenes. J Pharm Sci. 1986 Oct; 75(10):1010-3. PMID: 3795019.
      View in: PubMed
    387. Pool WF, Houdi AA, Damani LA, Layton WJ, Crooks PA. Isolation and characterization of N-methyl-N'-oxonicotinium ion, a new urinary metabolite of R-(+)-nicotine in the guinea pig. Drug Metab Dispos. 1986 Sep-Oct; 14(5):574-9. PMID: 2876864.
      View in: PubMed
    388. Damani LA, Shaker MS, Crooks PA, Godin CS, Nwosu C. N-methylation and quaternization of pyridine in vitro by rabbit lung, liver and kidney N-methyltransferases: an S-adenosyl-L-methionine-dependent reaction. Xenobiotica. 1986 Jul; 16(7):645-50. PMID: 3751119.
      View in: PubMed
    389. Sommerville R, Rosenberg HE, Crooks PA. Synthesis and pharmacological evaluation of aromatic dihydroxylated spiro[indan-1,3'-pyrrolidine] and spiro[indan-2,2'-pyrrolidine] derivatives. J Pharm Sci. 1985 May; 74(5):553-5. PMID: 4020632.
      View in: PubMed
    390. Cundy KC, Sato M, Crooks PA. Stereospecific in vivo N-methylation of nicotine in the guinea pig. Drug Metab Dispos. 1985 Mar-Apr; 13(2):175-85. PMID: 2859165.
      View in: PubMed
    391. Gillespie MN, Krechniak JW, Crooks PA, Altiere RJ, Olson JW. Pulmonary metabolism of exogenous enkephalins in isolated perfused rat lungs. J Pharmacol Exp Ther. 1985 Mar; 232(3):675-81. PMID: 2983067.
      View in: PubMed
    392. Deeks T, Crooks PA, Waigh RD. Leucine enkephalin analogues containing a conformationally restrained N-terminal amino acid residue. J Pharm Sci. 1984 Apr; 73(4):457-60. PMID: 6726628.
      View in: PubMed
    393. Gillespie MN, Bowdy BD, Reinsel CN, Iwamoto ET, Crooks PA. Leu-enkephalin provokes naloxone-insensitive pulmonary vasoconstriction. Life Sci. 1984 Mar 19; 34(12):1177-83. PMID: 6708723.
      View in: PubMed
    394. Crooks PA, Tribé MJ, Pinney RJ. Inhibition of bacterial DNA cytosine-5-methyltransferase by S-adenosyl-L-homocysteine and some related compounds. J Pharm Pharmacol. 1984 Feb; 36(2):85-9. PMID: 6143811.
      View in: PubMed
    395. Benghiat E, Crooks PA. Multisubstrate adducts as potential inhibitors of S-adenosylmethionine dependent methylases: inhibition of indole N-methyltransferase by (5'-deoxyadenosyl)[3-(3-indolyl)prop-1-yl]methylsulfonium and (5'-deoxyadenosyl)[4-(3-indolyl)but-1-yl]methylsulfonium salts. J Med Chem. 1983 Oct; 26(10):1470-7. PMID: 6620306.
      View in: PubMed
    396. Deeks T, Crooks PA, Waigh RD. Synthesis and analgesic properties of two leucine-enkephalin analogues containing a conformationally restrained N-terminal tyrosine residue. J Med Chem. 1983 May; 26(5):762-5. PMID: 6842517.
      View in: PubMed
    397. Hicks PE, Waldron C, Burn P, Crooks PA. alpha 2-Adrenoceptor agonist properties of exo- and endo-isomers of 2-amino-6,7,dihydroxybenzonorbornene designed as rigid catecholamines. J Pharm Pharmacol. 1983 Feb; 35(2):94-9. PMID: 6131993.
      View in: PubMed
    398. Damani LA, Crooks PA, Shaker MS, Caldwell J, D'Souza J, Smith RL. Species differences in the metabolic C- and N-oxidation , and N-methylation of [14C]pyridine in vivo. Xenobiotica. 1982 Aug; 12(8):527-34. PMID: 7147998.
      View in: PubMed
    399. Burn P, Crooks PA, Heatley F, Costall B, Naylor RJ, Nohria V. Synthesis and dopaminergic properties of some exo- and endo-2-aminobenzonorbornenes designed as rigid analogue of dopamine. J Med Chem. 1982 Apr; 25(4):363-8. PMID: 7200145.
      View in: PubMed
    400. Crooks PA, Sommerville R. The synthesis and analgesic activities of some spiro[indan-1,3'-pyrrolidine] derivatives designed as rigid analogs of profadol. J Pharm Sci. 1982 Mar; 71(3):291-4. PMID: 6461753.
      View in: PubMed
    401. Crooks PA, Szyndler R. Synthesis and analgesic properties of some conformationally restricted analogues of profadol. J Med Chem. 1980 Jun; 23(6):679-82. PMID: 6446605.
      View in: PubMed
    402. Crooks PA, Szyndler R, Cox B. 5,6- and 6,7-dihydroxyspiro (tetralin-1,3'-pyrrolidine): conformationally restricted analogues of dopamine. Pharm Acta Helv. 1980; 55(5):134-7. PMID: 7403196.
      View in: PubMed
    403. Deeks T, Crooks PA, Waigh RD. The synthesis and in vitro pharmacological evaluation of some novel enkephalin analogues [proceedings]. J Pharm Pharmacol. 1979 Dec; 31 Suppl:62P. PMID: 42739.
      View in: PubMed
    404. Crooks PA, Dreyer RN, Coward JK. Metabolism of S-adenosylhomocysteine and S-tubercidinylhomocysteine in neuroblastoma cells. Biochemistry. 1979 Jun 12; 18(12):2601-9. PMID: 444479.
      View in: PubMed
    405. Crooks PA, Breakefield XO, Sulens CH, Castiglione CM, Coward JK. Extensive conjugation of dopamine (3,4-dihydroxyphenethylamine) metabolites in cultured human skin fibroblasts and rat hepatoma cells. Biochem J. 1978 Oct 15; 176(1):187-96. PMID: 569477.
      View in: PubMed
    406. Crooks PA, Rosenberg HE. Synthesis of spiro[tetralin-2,2'-pyrrolidine] and spiro[indan-2,2'-pyrrolidine] derivatives as potential analgesics. J Med Chem. 1978 Jun; 21(6):585-7. PMID: 671457.
      View in: PubMed
    407. Burn P, Crooks PA, Rees JM. Antinociceptive and sympathomimetic activities of exo-andendo-2-aminobenzonorbornene and their N-methylated derivatives [proceedings]. J Pharm Pharmacol. 1976 Dec; 28 Suppl:80P. PMID: 12360.
      View in: PubMed
    408. Crooks PA, Rosenberg HE. The synthesis and antinociceptive properties of spiro (indan -2, 2(1) -pyrrolidine), spiro (tetralin -2, 2(1) - pyrrolidine) and their N-methyl derivatives [proceedings]. J Pharm Pharmacol. 1976 Dec; 28 Suppl:83P. PMID: 12363.
      View in: PubMed
    409. Crooks PA, Collett JH, Withington R. The determination of the hydrophile-hydrophobe proton ratio in a series of polyoxyethylene sorbitan esters. Pharm Acta Helv. 1974; 49(7-8):274-6. PMID: 4462134.
      View in: PubMed
    410. Crooks PA, Little HJ, Rees JM. Proceedings: The effects of amphetamine, 2-aminoindane and 2-aminotetralin on the concentrations of whole brain noradrenaline, dopamine, 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in the mouse. J Pharm Pharmacol. 1973 Dec; 25:Suppl:124P. PMID: 4150521.
      View in: PubMed
    411. Crooks PA, Robinson B. Conopharyngine pseudoindoxyl, a new alkaloid from Tabernamontana pachysiphon Stapf. var cumminsii (Stapf.) H. Huber. J Pharm Pharmacol. 1973 Oct; 25(10):820-3. PMID: 4149744.
      View in: PubMed
    Crooks's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description
    Physical Neighbors Expand Description
    _