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Youzhong Yuan

TitleAssistant Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPathology, College of Medicine
DivisionPathology Administration
Address4200 Shuffield.
Mail Slot # 502
Little Rock AR 72205
Phone501-526-5072
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    Collapse Affiliation 
    Collapse clinical activities
    Hematopathology

    Collapse Biography 
    Collapse Leadership and Administrative Roles
    Medical Director of Tissue Bank, UAMS


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Gralewski JH, Post GR, van Rhee F, Yuan Y. Myeloid transformation of plasma cell myeloma: molecular evidence of clonal evolution revealed by next generation sequencing. Diagn Pathol. 2018 Feb 20; 13(1):15. PMID: 29463311.
      View in: PubMed
    2. Post GR, Bell RC, Rjoop A, Lobo RH, Yuan Y, Post SR. Diagnostic Utility of Interleukin-6 Expression by Immunohistochemistry in Differentiating Castleman Disease Subtypes and Reactive Lymphadenopathies. Ann Clin Lab Sci. 2016 Sep; 46(5):474-9. PMID: 27650613.
      View in: PubMed
    3. Gao Y, Yang P, Shen H, Yu H, Song X, Zhang L, Zhang P, Cheng H, Xie Z, Hao S, Dong F, Ma S, Ji Q, Bartlow P, Ding Y, Wang L, Liu H, Li Y, Cheng H, Miao W, Yuan W, Yuan Y, Cheng T, Xie XQ. Small-molecule inhibitors targeting INK4 protein p18(INK4C) enhance ex vivo expansion of haematopoietic stem cells. Nat Commun. 2015 Feb 18; 6:6328. PMID: 25692908; PMCID: PMC4508125.
    4. Li Y, Feng H, Gu H, Lewis DW, Yuan Y, Zhang L, Yu H, Zhang P, Cheng H, Miao W, Yuan W, Cheng SY, Gollin SM, Cheng T. The p53-PUMA axis suppresses iPSC generation. Nat Commun. 2013; 4:2174. PMID: 23873265; PMCID: PMC4394110.
    5. Xiang M, Yuan Y, Fan L, Li Y, Li A, Yin L, Scott MJ, Xiao G, Billiar TR, Wilson MA, Fan J. Role of macrophages in mobilization of hematopoietic progenitor cells from bone marrow after hemorrhagic shock. Shock. 2012 May; 37(5):518-23. PMID: 22293600; PMCID: PMC3328610.
    6. Shen H, Yu H, Liang PH, Cheng H, XuFeng R, Yuan Y, Zhang P, Smith CA, Cheng T. An acute negative bystander effect of ?-irradiated recipients on transplanted hematopoietic stem cells. Blood. 2012 Apr 12; 119(15):3629-37. PMID: 22374698; PMCID: PMC3325047.
    7. Yu H, Shen H, Yuan Y, XuFeng R, Hu X, Garrison SP, Zhang L, Yu J, Zambetti GP, Cheng T. Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to high-dose gamma-irradiation. Blood. 2010 Apr 29; 115(17):3472-80. PMID: 20177048; PMCID: PMC2867261.
    8. Li Y, Xiang M, Yuan Y, Xiao G, Zhang J, Jiang Y, Vodovotz Y, Billiar TR, Wilson MA, Fan J. Hemorrhagic shock augments lung endothelial cell activation: role of temporal alterations of TLR4 and TLR2. Am J Physiol Regul Integr Comp Physiol. 2009 Dec; 297(6):R1670-80. PMID: 19828841; PMCID: PMC2803625.
    9. Cao Z, Yuan Y, Jeyabalan G, Du Q, Tsung A, Geller DA, Billiar TR. Preactivation of NKT cells with alpha-GalCer protects against hepatic ischemia-reperfusion injury in mouse by a mechanism involving IL-13 and adenosine A2A receptor. Am J Physiol Gastrointest Liver Physiol. 2009 Aug; 297(2):G249-58. PMID: 19556359; PMCID: PMC2724078.
    10. Liu Y, Yuan Y, Li Y, Zhang J, Xiao G, Vodovotz Y, Billiar TR, Wilson MA, Fan J. Interacting neuroendocrine and innate and acquired immune pathways regulate neutrophil mobilization from bone marrow following hemorrhagic shock. J Immunol. 2009 Jan 01; 182(1):572-80. PMID: 19109190; PMCID: PMC2610356.
    11. Zhang X, Vallabhaneni R, Loughran PA, Shapiro R, Yin XM, Yuan Y, Billiar TR. Changes in FADD levels, distribution, and phosphorylation in TNFalpha-induced apoptosis in hepatocytes is caspase-3, caspase-8 and BID dependent. Apoptosis. 2008 Aug; 13(8):983-92. PMID: 18543108.
      View in: PubMed
    12. Tan X, Yuan Y, Zeng G, Apte U, Thompson MD, Cieply B, Stolz DB, Michalopoulos GK, Kaestner KH, Monga SP. Beta-catenin deletion in hepatoblasts disrupts hepatic morphogenesis and survival during mouse development. Hepatology. 2008 May; 47(5):1667-79. PMID: 18393386; PMCID: PMC4449338.
    13. Song X, Yuan Y, Shen H, Yu H, Xu F, Huang P, Shields D, Wang J, Cheng T. Long-term engraftment of p18(INK4C)-deficient hematopoietic stem cells is enhanced in the sublethally-irradiated recipients. Sci China C Life Sci. 2006 Aug; 49(4):390-4. PMID: 16989285.
      View in: PubMed
    14. Yuan Y, Yu H, Boyer MJ, Song X, Cao S, Shen H, Cheng T. Hematopoietic stem cells are not the direct target of spontaneous leukemic transformation in p18(INK4C)-null reconstituted mice. Cancer Res. 2006 Jan 01; 66(1):343-51. PMID: 16397248.
      View in: PubMed
    15. Yu H, Yuan Y, Shen H, Cheng T. Hematopoietic stem cell exhaustion impacted by p18 INK4C and p21 Cip1/Waf1 in opposite manners. Blood. 2006 Feb 01; 107(3):1200-6. PMID: 16234365; PMCID: PMC1895913.
    16. Yuan Y, Shen H, Franklin DS, Scadden DT, Cheng T. In vivo self-renewing divisions of haematopoietic stem cells are increased in the absence of the early G1-phase inhibitor, p18INK4C. Nat Cell Biol. 2004 May; 6(5):436-42. PMID: 15122268.
      View in: PubMed
    17. Malakhova OA, Yan M, Malakhov MP, Yuan Y, Ritchie KJ, Kim KI, Peterson LF, Shuai K, Zhang DE. Protein ISGylation modulates the JAK-STAT signaling pathway. Genes Dev. 2003 Feb 15; 17(4):455-60. PMID: 12600939; PMCID: PMC195994.
    18. Yuan Y, Zhou L, Miyamoto T, Iwasaki H, Harakawa N, Hetherington CJ, Burel SA, Lagasse E, Weissman IL, Akashi K, Zhang DE. AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations. Proc Natl Acad Sci U S A. 2001 Aug 28; 98(18):10398-403. PMID: 11526243; PMCID: PMC56972.
    19. Lin S, McLennan AG, Ying K, Wang Z, Gu S, Jin H, Wu C, Liu W, Yuan Y, Tang R, Xie Y, Mao Y. Cloning, expression, and characterization of a human inosine triphosphate pyrophosphatase encoded by the itpa gene. J Biol Chem. 2001 Jun 01; 276(22):18695-701. PMID: 11278832.
      View in: PubMed
    20. Zhang DE, Burel S, Zhou L, Hetherington CJ, Yuan Y. AML1 and AML1 fusion protein AML1-ETO in myeloid gene regulation and leukemogenesis. Blood Cells Mol Dis. 2001 Mar-Apr; 27(2):368-76. PMID: 11259158.
      View in: PubMed
    21. Xia F, Yuan Y, Chen R, Liu P, Zhou H, Wang J. [Study of telomerase activity and its related genes expression in leukemia cells]. Zhonghua Xue Ye Xue Za Zhi. 2001 Feb; 22(2):86-9. PMID: 11877056.
      View in: PubMed
    22. Yuan YZ, Zhao SH, Zhou ZX, Ji CN, Sheng XY, Mao YM. [A study of a mutant of thermostable alkaline phosphatase]. Yi Chuan Xue Bao. 2000; 27(4):361-8. PMID: 11147356.
      View in: PubMed
    23. Cao Y, Qiao S, Yuan Y, Huang J, Zhao S. Isolation of ScFv antibodies of rP27( kip 1) from phage display libraries constructed from immunized and non-immunized repertoires. Sci China C Life Sci. 1999 Aug; 42(4):376-82. PMID: 18763128.
      View in: PubMed
    24. Zhu W, Zheng ZH, Yuan YZ, Zhou ZX, Mao YM. [Correlation analysis of (G + C)% of coding sequence and thermostability of xylose isomerase of thermophiles]. Yi Chuan Xue Bao. 1999; 26(4):418-27. PMID: 10593023.
      View in: PubMed
    25. Xue Y, Lu D, Yuan YZ, Guo Y, Xie X. A rare variant translocation t(3;8)(q29;q22) without AML1/ETO fusion transcript in a case of oligoblastic leukemia. Leuk Res. 1998 Nov; 22(11):1015-9. PMID: 9783804.
      View in: PubMed
    26. Xia F, Yuan Y, Zhang W. [Study on expression of IRF-1 gene in human leukemia with RT-PCR and the silver sequence techniques]. Zhonghua Xue Ye Xue Za Zhi. 1998 Jan; 19(1):13-5. PMID: 10921095.
      View in: PubMed
    27. Yuan YZ, Sheng XY, Lu HY, Tong S, Mao YM. [Thermostable alkaline phosphatase from Thermus sp. FD3041: cloning of the gene and expression in Escherichia coli]. Yi Chuan Xue Bao. 1998; 25(4):375-80. PMID: 10067283.
      View in: PubMed
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