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Lawrence Cornett

TitleProfessor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPhysiology & Biophysics, College of Medicine
DivisionPhysiology & Biophysics Faculty
Address159-2 Biomedical Research II
200 South Cedar
Mail Slot # 505
Little Rock AR 72202
Phone501-686-5441
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    Other Positions
    TitleProfessor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentInternal Medicine, College of Medicine
    DivisionPulmonary & Critical Care


    Collapse Overview 
    Collapse overview
    Dr. Cornett is a professor in the Department of Physiology and Biophysics at the University of Arkansas for Medical Sciences and the Vice Chancellor for Research. Dr. Cornett earned a BS in biology from the University of California, Riverside, his PhD in physiology from the University of California, Davis and was a postdoctoral fellow in reproductive endocrinology and cardiovascular physiology at the University of California, San Francisco. His research interest include the role of beta2-adrenergic receptors in mediating airway responsiveness in asthma and hormonal regulation of stress responses at the level of the pituitary gland. In addition, Dr. Cornett is the Director of the Arkansas IDeA Network of Biomedical Research Excellence (INBRE), a program funding by the National Institutes of Health to develop biomedical research infrastructure in the state. Dr. Cornett is a member of American Association of Medical Colleges GRAND Steering Committee, the Board of Directors of the National Space Biomedical Research Institute, executive committee of the National Association of IDeA Principal Investigators, and the EPSCoR/IDeA Foundation Board. Among his many honors, Dr. Cornett received a fellowship from the NIH Fogarty Center and a Research Career Enhancement Award from the American Physiological Society.


    Collapse Affiliation 
    Collapse member of
    Endocrine Society
    American Physiological Society

    Collapse Biography 
    Collapse Leadership and Administrative Roles
    Director, Arkansas INBRE

    Vice Chancellor for Research


    Collapse Research Funds 
    Collapse research activities
    5 P20 GM103429     (CORNETT, LAWRENCE E)May 1, 2016 - Apr 30, 2017
    NIH
    Partnerships for Biomedical Research in Arkansas
    Role: Principal Investigator

    P20GM103625     (SMELTZER, MARK S)Aug 15, 2012 - Apr 30, 2022
    NIH/NIGMS
    Center for Microbial Pathogenesis and Host Inflammatory Responses
    Role: Co-Investigator

    P20RR016460     (CORNETT, LAWRENCE E)Aug 31, 2009 - Sep 29, 2004
    NIH/NCRR
    Partnerships for Biomedical Research in Arkansas
    Role: Principal Investigator

    IBN-0111006     (CORNETT, LAWRENCE)Jun 1, 2002 - May 31, 2006
    National Science Foundation
    Cloning and Functional Characterization of an Avian Pituitary Gland Vasotocin Receptor
    Role: Principal Investigator

    P20GM103429     (CORNETT, LAWRENCE E)Sep 30, 2001 - Apr 30, 2020
    NIH/NIGMS
    Partnerships for Biomedical Research in Arkansas
    Role: Principal Investigator

    2001-35208-10842     (CORNETT, LAWRENCE)Sep 1, 2001 - Aug 31, 2004
    US Department of Agriculture
    Neuroendocrine Control of Shell Gland Contractility in the Domestic Hen
    Role: Principal Investigator

    R01AM034507     (CORNETT, LAWRENCE E)Apr 1, 1985 - Mar 31, 1988
    NIH/NIADDK
    BIOCHEMICAL STUDIES OF VASOPRESSIN RECEPTORS
    Role: Principal Investigator

    R01DK034507     (CORNETT, LAWRENCE E)Apr 1, 1985 - Mar 31, 1988
    NIH/NIDDK
    BIOCHEMICAL STUDIES OF VASOPRESSIN RECEPTORS
    Role: Principal Investigator

    R01GM030669     (CORNETT, LAWRENCE E)Dec 1, 1983 - Nov 30, 1986
    NIH/NIGMS
    ADRENERGIC RECEPTORS IN A SMOOTH MUSCLE CELL LINE
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Srivastava R, Cornett LE, Chaturvedi CM. Impact of estrogen and photoperiod on arginine vasotocin and VT3 receptor expression in the shell gland of quail. Front Biosci (Schol Ed). 2018 06 01; 10:372-385. PMID: 29772564.
      View in: PubMed
    2. McSweeney JC, Hudson TJ, Prince L, Beneš H, Tackett AJ, Miller Robinson C, Koeppe R, Cornett LE. Impact of the INBRE summer student mentored research program on undergraduate students in Arkansas. Adv Physiol Educ. 2018 Mar 01; 42(1):123-129. PMID: 29446316.
      View in: PubMed
    3. Cornett LE, Kang SW, Kuenzel WJ. A possible mechanism contributing to the synergistic action of vasotocin (VT) and corticotropin-releasing hormone (CRH) receptors on corticosterone release in birds. Gen Comp Endocrinol. 2013 Jul 01; 188:46-53. PMID: 23499785.
      View in: PubMed
    4. Koryakina Y, Jones SM, Cornett LE, Seely K, Brents L, Prather PL, Kofman A, Kurten RC. Effects of the ß-agonist, isoprenaline, on the down-regulation, functional responsiveness and trafficking of ß2-adrenergic receptors with N-terminal polymorphisms. Cell Biol Int. 2012; 36(12):1171-83. PMID: 22938397.
      View in: PubMed
    5. Srivastava R, Cornett LE, Chaturvedi CM. Age-dependent expression of AVT and its oxytocic-like receptor VT3 in the shell gland of Japanese quail, Coturnix coturnix japonica. Gen Comp Endocrinol. 2010 Jan 01; 165(1):47-52. PMID: 19505466.
      View in: PubMed
    6. Sharma D, Cornett LE, Chaturvedi CM. Corticosterone- or metapyrone-induced alterations in adrenal function and expression of the arginine vasotocin receptor VT2 in the pituitary gland of domestic fowl, Gallus gallus. Gen Comp Endocrinol. 2009 Apr; 161(2):208-15. PMID: 19523400.
      View in: PubMed
    7. Sharma D, Cornett LE, Chaturvedi CM. Osmotic stress induced alteration in the expression of arginine vasotocin receptor VT2 in the pituitary gland and adrenal function of domestic fowl. Gen Comp Endocrinol. 2009 Feb 01; 160(3):216-22. PMID: 19073186.
      View in: PubMed
    8. Srivastava R, Cornett LE, Chaturvedi CM. Effect of estrogen and its antagonist on the expression of arginine vasotocin (AVT) and its oxytocic-like receptor VT3 in the shell gland of Japanese quail, Coturnix coturnix japonica. Comp Biochem Physiol A Mol Integr Physiol. 2008 Dec; 151(4):551-9. PMID: 18678266.
      View in: PubMed
    9. Jurkevich A, Berghman LR, Cornett LE, Kuenzel WJ. Immunohistochemical characterization of chicken pituitary cells containing the vasotocin VT2 receptor. Cell Tissue Res. 2008 Aug; 333(2):253-62. PMID: 18548280.
      View in: PubMed
    10. Mikhailova MV, Blansett J, Jacobi S, Mayeux PR, Cornett LE. Transmembrane domain IV of the Gallus gallus VT2 vasotocin receptor is essential for forming a heterodimer with the corticotrophin releasing hormone receptor. J Biomed Opt. 2008 May-Jun; 13(3):031208. PMID: 18601532.
      View in: PubMed
    11. Koryakina YA, Fowler TW, Jones SM, Schnackenberg BJ, Cornett LE, Kurten RC. Characterization of a panel of six beta2-adrenergic receptor antibodies by indirect immunofluorescence microscopy. Respir Res. 2008 Apr 18; 9:32. PMID: 18423037.
      View in: PubMed
    12. Srivastava R, Cornett LE, Chaturvedi CM. Effect of photoperiod and estrogen on expression of arginine vasotocin and its oxytocic-like receptor in the shell gland of the Japanese quail. Comp Biochem Physiol A Mol Integr Physiol. 2007 Oct; 148(2):451-7. PMID: 17627858.
      View in: PubMed
    13. Mikhailova MV, Mayeux PR, Jurkevich A, Kuenzel WJ, Madison F, Periasamy A, Chen Y, Cornett LE. Heterooligomerization between vasotocin and corticotropin-releasing hormone (CRH) receptors augments CRH-stimulated 3',5'-cyclic adenosine monophosphate production. Mol Endocrinol. 2007 Sep; 21(9):2178-88. PMID: 17536010.
      View in: PubMed
    14. Mikhailova MV, Mayeux P, Jurkevich A, Kuenzel WJ, Periasamy A, Chen Y, Cornett LE. Hetero-oligomerization between vasotocin and corticotrophin-releasing hormone (CRH) receptors augments CRH-stimulated cyclic AMP production. Molecular Endocrinology. 2007; 21:2178-2188.
    15. Schnackenberg BJ, Jones SM, Pate C, Shank B, Sessions L, Pittman LM, Cornett LE, Kurten RC. Isoproterenol, a ?-agonist, attenuates EGF-stimulated wound closure in human airway epithelial cells. American Journal of Physiology. 2006; 290:L485-L491.
    16. Baeyens DA, Cornett LE. The cloned avian neurohypophysial hormone receptors. Comp Biochem Physiol B Biochem Mol Biol. 2006 Jan; 143(1):12-9. PMID: 16311051.
      View in: PubMed
    17. Schnackenberg BJ, Jones SM, Pate C, Shank B, Sessions L, Pittman LM, Cornett LE, Kurten RC. The beta-agonist isoproterenol attenuates EGF-stimulated wound closure in human airway epithelial cells. . 2006 Mar; 290(3):L485-91. PMID: 16227322.
      View in: PubMed
    18. Gubrij KI, Chaturvedi CM, Ali N, Cornett LE, Kirby JD, Wilkerson J, Mikhailova M, Turner ML, Baeyens DA. Molecular cloning of an oxytocin-like receptor expressed in the chicken shell gland. Comp Biochem Physiol B Biochem Mol Biol. 2005 Sep; 142(1):37-45. PMID: 16005652.
      View in: PubMed
    19. Jurkevich A, Berghman LR, Cornett LE, Kuenzel WJ. Characterization and immunohistochemical visualization of the vasotocin VT2 receptor in the pituitary gland of the chicken, Gallus gallus. Gen Comp Endocrinol. 2005 Aug; 143(1):82-91. PMID: 15993108.
      View in: PubMed
    20. Jones SM, Hiller FC, Jacobi SE, Foreman SK, Pittman LM, Cornett LE. Enhanced beta2-adrenergic receptor (beta2AR) signaling by adeno-associated viral (AAV)-mediated gene transfer. BMC Pharmacol. 2003 Dec 04; 3:15. PMID: 14656380.
      View in: PubMed
    21. Cornett LE, Kirby JD, Vizcarra JA, Ellison JC, Thrash J, Mayeux PR, Crew MD, Jones SM, Ali N, Baeyens DA. Molecular cloning and functional characterization of a vasotocin receptor subtype expressed in the pituitary gland of the domestic chicken (Gallus domesticus): avian homolog of the mammalian V1b-vasopressin receptor. Regul Pept. 2003 Feb 28; 110(3):231-9. PMID: 12573805.
      View in: PubMed
    22. Chaturvedi CM, Chowdhary A, Cornett LE. Water deprivation and diurnal changes in plasma arginine vasotocin and mesotocin in the domestic hen (Gallus domesticus). Chronobiology International. 2001; 18:947-956.
    23. Baeyens DA, Kelly JG, Foreman SK, Jacobi SE, McGraw DW, Cornett LE. Transcriptional regulation of ?2-adrenergic receptor gene expression in the developing male rat liver. 1996.
    24. Chaturvedi CM, Zheng Z, Shimada K, Cornett LE, Koike TI. Changes in poly(A) tail length of arginine vasotocin ribonucleic acid in the hypothalamus of water deprived chickens. General and Comparative Endocrinology. 1996; 103:316-322.
    25. McGraw DW, Jacobi SE, Hiller FC, Cornett LE. Cis-acting regulatory elements in the distal 5’-flanking region of the rat ?2-adrenergic receptor gene. 1995.
    26. Randall EB, Foreman SK, Baeyens DA, Cornett LE. A Mr 85,000 protein binds selectively to an AU-containing segment of the ?2-adrenergic receptor mRNA 3’-untranslated region. 1995.
    27. Cornett LE, McGraw DW, Dicker-Brown A, Deng C-I. Identification of an alternatively spliced intron in the 5’-flanking region of the rat ?1B-adrenergic receptor gene. 1995.
    28. Baeyens DA, Foreman SK, MacLeod V, Cornett LE. Destabilitzation of hepatic ?2-adrenergic receptor mRNA during development is associated with a Mr 85,000 protein that binds to the ?2-adrenergic receptor mRNA 3’-untranslated region. 1994.
    29. Chaturvedi CM, Zheng Z, Cornett LE, Koike TI. Central and peripheral vasotocin gene expression in chickens detected by reverse transcription-polymerase chain reaction. 1994.
    30. McGraw DW, Chai SE, Hiller FC, Cornette LE. *2-Adrenergic receptor and mRNA levels in rat lungs following in vivo administration of glucocorticoids. 1993.
    31. Cornett LE. Textbook of Physiology. The Adrenal Medulla. 1989.
    32. Cornett LE. Peptide Hormone Receptors. Vasopressin receptors. 1987.
    33. Norris JS, Cornett LE, Harris SE, Nag A, Rossby P, Srivastava A, MacLeod SL, Smith RG. Advances in Gene Technology: Molecular Biology of the Endocrine System. Investigation of glucocorticoid receptor regulation of autocrine growth in a smooth muscle tumor cell line. 1986.
    34. Cornett LE, Bavister BD, Meizel S. Adrenergic stimulation of fertilizing ability of hamster spermatozoa. Biology of Reproduction. 1980; 20:925-929.
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