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Christian Herzog

TitleAssistant Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentInternal Med, College of Medicine
DivisionInternal Med Nephrology
Address Campus General
200 South Cedar
Mail Slot # 501
Little Rock AR 72202
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    Collapse Affiliation 
    Collapse Translational Research Institute: Clinical and Translational Science Award
    CCTR Pilot Study grant: 1UL1RR029884
    Title: Nidogen as a Biomarker in Early Detection of Acute Kidney Injury

    Collapse member of
    American Society of Nephrology

    Collapse Research Funds 
    Collapse research activities
    U01DK103225     (ARTHUR, JOHN)Jul 1, 2017 - Jun 30, 2018
    NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases - Pass Through: University of Pennsylvania
    Pilot: Glomerular biomarkers of progression in IgA nephropathy
    Role: Co-Investigator

    R01DK081690     (KAUSHAL, GUR PRASAD)Mar 1, 2010 - Feb 28, 2014
    Meprin A Metalloproteinase in Acute Kidney Injury
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Herzog C, Haun RS, Kaushal GP. Role of meprin metalloproteinases in cytokine processing and inflammation. Cytokine. 2019 02; 114:18-25. PMID: 30580156.
      View in: PubMed
    2. Herzog C, Haun RS, Shah SV, Kaushal GP. Proteolytic processing and inactivation of CCL2/MCP-1 by meprins. Biochem Biophys Rep. 2016 Dec; 8:146-150. PMID: 28955950.
      View in: PubMed
    3. Herzog C, Marisiddaiah R, Haun RS, Kaushal GP. Basement membrane protein nidogen-1 is a target of meprin ß in cisplatin nephrotoxicity. Toxicol Lett. 2015 Jul 16; 236(2):110-6. PMID: 25957482.
      View in: PubMed
    4. Herzog C, Haun RS, Ludwig A, Shah SV, Kaushal GP. ADAM10 is the major sheddase responsible for the release of membrane-associated meprin A. J Biol Chem. 2014 May 09; 289(19):13308-22. PMID: 24662289.
      View in: PubMed
    5. Kaushal V, Herzog C, Haun RS, Kaushal GP. Caspase protocols in mice. Methods Mol Biol. 2014; 1133:141-54. PMID: 24567100.
      View in: PubMed
    6. Kaushal GP, Haun RS, Herzog C, Shah SV. Meprin A metalloproteinase and its role in acute kidney injury. Am J Physiol Renal Physiol. 2013 May 01; 304(9):F1150-8. PMID: 23427141.
      View in: PubMed
    7. Herzog C, Yang C, Holmes A, Kaushal GP. zVAD-fmk prevents cisplatin-induced cleavage of autophagy proteins but impairs autophagic flux and worsens renal function. Am J Physiol Renal Physiol. 2012 Oct 15; 303(8):F1239-50. PMID: 22896037.
      View in: PubMed
    8. Wang Z, Herzog C, Kaushal GP, Gokden N, Mayeux PR. Actinonin, a meprin A inhibitor, protects the renal microcirculation during sepsis. Shock. 2011 Feb; 35(2):141-7. PMID: 20577148.
      View in: PubMed
    9. Liu L, Yang C, Herzog C, Seth R, Kaushal GP. Proteasome inhibitors prevent cisplatin-induced mitochondrial release of apoptosis-inducing factor and markedly ameliorate cisplatin nephrotoxicity. Biochem Pharmacol. 2010 Jan 15; 79(2):137-46. PMID: 19699182.
      View in: PubMed
    10. Herzog C, Haun RS, Kaushal V, Mayeux PR, Shah SV, Kaushal GP. Meprin A and meprin alpha generate biologically functional IL-1beta from pro-IL-1beta. Biochem Biophys Res Commun. 2009 Feb 20; 379(4):904-8. PMID: 19135030.
      View in: PubMed
    11. Kaushal GP, Kaushal V, Herzog C, Yang C. Autophagy delays apoptosis in renal tubular epithelial cells in cisplatin cytotoxicity. Autophagy. 2008 Jul; 4(5):710-2. PMID: 18497570.
      View in: PubMed
    12. Herzog C, Kaushal GP, Haun RS. Generation of biologically active interleukin-1beta by meprin B. Cytokine. 2005 Sep 07; 31(5):394-403. PMID: 16095909.
      View in: PubMed
    13. Pal A, Gu Y, Herzog C, Srivastava SK, Zimniak P, Ji X, Singh SV. Role of arginine 216 in catalytic activity of murine Alpha class glutathione transferases mGSTAl-1 and mGSTA2-2 toward carcinogenic diol epoxides of polycyclic aromatic hydrocarbons. Carcinogenesis. 2001 Aug; 22(8):1301-5. PMID: 11470762.
      View in: PubMed
    14. Pal A, Desai DH, Amin S, Srivastava SK, Hu X, Herzog C, Zimniak P, Singh SV. Location of the epoxide function determines specificity of the allelic variants of human glutathione transferase Pi toward benzo[c]chrysene diol epoxide isomers. FEBS Lett. 2000 Dec 08; 486(2):163-6. PMID: 11113459.
      View in: PubMed
    15. Ji X, Blaszczyk J, Xiao B, O'Donnell R, Hu X, Herzog C, Singh SV, Zimniak P. Structure and function of residue 104 and water molecules in the xenobiotic substrate-binding site in human glutathione S-transferase P1-1. Biochemistry. 1999 Aug 10; 38(32):10231-8. PMID: 10441116.
      View in: PubMed
    16. Hu X, Herzog C, Zimniak P, Singh SV. Differential protection against benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced DNA damage in HepG2 cells stably transfected with allelic variants of pi class human glutathione S-transferase. Cancer Res. 1999 May 15; 59(10):2358-62. PMID: 10344744.
      View in: PubMed
    17. Maté MJ, Zamocky M, Nykyri LM, Herzog C, Alzari PM, Betzel C, Koller F, Fita I. Structure of catalase-A from Saccharomyces cerevisiae. J Mol Biol. 1999 Feb 12; 286(1):135-49. PMID: 9931255.
      View in: PubMed
    18. Hu X, Xia H, Srivastava SK, Herzog C, Awasthi YC, Ji X, Zimniak P, Singh SV. Activity of four allelic forms of glutathione S-transferase hGSTP1-1 for diol epoxides of polycyclic aromatic hydrocarbons. Biochem Biophys Res Commun. 1997 Sep 18; 238(2):397-402. PMID: 9299520.
      View in: PubMed
    19. Zamocky M, Herzog C, Nykyri LM, Koller F. Site-directed mutagenesis of the lower parts of the major substrate channel of yeast catalase A leads to highly increased peroxidatic activity. FEBS Lett. 1995 Jul 03; 367(3):241-5. PMID: 7607315.
      View in: PubMed
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