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Laura James

TitleProfessor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPediatrics, College of Medicine
DivisionPeds Pharmacology
AddressS3117 ACH Sturgis Building
800 Marshall Street
Mail Slot # 512
Little Rock AR 72202
Phone501-364-1418
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    Other Positions
    TitleAssociate Vice Chancellor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentClinical and Translational Research


    Collapse Overview 
    Collapse overview
    Dr. James is the Director of the Translational Research Institute at the University of Arkansas for Medical Sciences. Her research interest is in translational studies of acetaminophen toxicity. She and her collaborators developed novel approaches for the quantitation of acetaminophen protein adducts in peripheral blood samples. She also directs clinical trials in children to develop safe and effective drug dosing strategies in a number of disease areas.


    Collapse Biography 
    Collapse Leadership and Administrative Roles
    Director, Translational Research Institute

    Collapse credentials

    Collapse Research Funds 
    Collapse principal investigator/co-principal investigator research activities
    UL1TR003107     (JAMES, LAURA P)Jul 1, 2019 - Jun 30, 2024
    NIH/NCATS
    Expanding Translational Research in Arkansas
    Role: Principal Investigator

    U54TR001629     (JAMES, LAURA P)Sep 26, 2017 - Aug 31, 2018
    NIH/NCATS
    Expanding Translational Research in Arkansas
    Role: Principal Investigator

    1UG1HD090876     (JAMES, LAURA P)Oct 1, 2016 - Sep 30, 2020
    NIH
    Arkansas Center for Advancing Pediatric Therapeutics
    Role: Principal Investigator

    UG1HD090876     (KEARNS, GREGORY LEE)Sep 21, 2016 - Aug 31, 2020
    NIH/NICHD
    Arkansas Center for Advancing Pediatric Therapeutics (ArCAPT)
    Role: Co-Principal Investigator

    UG1OD024945     (KEARNS, GREGORY LEE)Sep 21, 2016 - Aug 31, 2020
    NIH
    Arkansas Center for Advancing Pediatric Therapeutics (ArCAPT)
    Role: Co-Principal Investigator

    R01-DA039143     Sep 1, 2016 - Aug 30, 2021
    NIH
    Synthetic Cannabinoid Toxicity: Role of Biotransformation
    Role: Co-Investigator

    R01DA039143     (PRATHER, PAUL L)May 15, 2016 - Apr 30, 2021
    NIH/NIDA
    Synthetic Cannabinoid Toxicity: Role of Biotransformation
    Role: Co-Investigator

    2R42DK079387     (JAMES, LAURA P)Apr 1, 2016 - Mar 3, 2019
    NIH/NIDDK
    Adduct Dipstick for Diagnosis of Acetaminophen Toxicity
    Role: Principal Investigator

    P20GM103625     (SMELTZER, MARK S)Aug 15, 2012 - Apr 30, 2022
    NIH/NIGMS
    Center for Microbial Pathogenesis and Host Inflammatory Responses
    Role: Co-Investigator

    KL2TR000063     (LOWERY, CURTIS L)Jul 14, 2009 - Mar 31, 2015
    NIH/NCATS
    Arkansas Center for Clinical Translational Research
    Role: Co-Principal Investigator

    UL1TR000039     (LOWERY, CURTIS L)Jul 14, 2009 - Mar 31, 2015
    NIH/NCATS
    Arkansas Center for Clinical and Translational Research
    Role: Co-Principal Investigator

    R01DK081406     (JAMES, LAURA P)Jun 15, 2009 - Mar 31, 2014
    NIH/NIDDK
    Identification of new mechanistic biomarkers of adverse responses to acetaminophe
    Role: Principal Investigator

    R41DK079387     (JAMES, LAURA P)Apr 1, 2008 - Mar 31, 2011
    NIH/NIDDK
    Dipstick Assay for Detection of Acetaminophen Protein Adducts
    Role: Principal Investigator

    R01DK075936     (JAMES, LAURA P)Aug 24, 2007 - May 31, 2014
    NIH/NIDDK
    HIF-1alpha and VEGF in Acetaminophen Toxicity and Repair
    Role: Principal Investigator

    R42DK079387     (JAMES, LAURA PHILLIPS)Jul 1, 2007 - Mar 31, 2019
    NIH/NIDDK
    AcetaSTAT Rapid Assay for Acetaminophen Liver Injury
    Role: Principal Investigator

    R03DK067999     (JAMES, LAURA P)Sep 1, 2004 - Aug 31, 2007
    NIH/NIDDK
    Evaluation of a Biomarker for Acetaminophen Toxicity
    Role: Principal Investigator

    K08DK002971     (JAMES, LAURA P)Feb 15, 2001 - Nov 30, 2005
    NIH/NIDDK
    NOVEL THERAPIES FOR ACETAMINOPHEN TOXICITY
    Role: Principal Investigator

    U10HD031324     (JAMES, LAURA P)Mar 21, 1994 - Dec 31, 2010
    NIH/NICHD
    Pediatric Pharmacology Research Unit Network
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. McCullough S, Dweep H, McGill MR, Bhattacharyya S, James L, Frankowski S, Woodall A, Kearns G, Gill P. Granzyme B and miR-378a Interaction in Acetaminophen Toxicity in Children. Microrna. 2019 Aug 08. PMID: 31393259.
      View in: PubMed
    2. Ewing LE, McGill MR, Yee EU, Quick CM, Skinner CM, Kennon-McGill S, Clemens M, Vazquez JH, McCullough SS, Williams DK, Kutanzi KR, Walker LA, ElSohly MA, James LP, Gurley BJ, Koturbash I. Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration. Molecules. 2019 Jun 17; 24(12). PMID: 31212965.
      View in: PubMed
    3. Jiang S, Vozmediano V, Abdel-Rahman SM, Schmidt S, James LP. Acetaminophen Protein Adducts in Hospitalized Children Receiving Multiple Doses of Acetaminophen. J Clin Pharmacol. 2019 Oct; 59(10):1291-1299. PMID: 31099052.
      View in: PubMed
    4. Long CR, Purvis RS, Flood-Grady E, Kimminau KS, Rhyne RL, Burge MR, Stewart MK, Jenkins AJ, James LP, McElfish PA. Health researchers' experiences, perceptions and barriers related to sharing study results with participants. Health Res Policy Syst. 2019 Mar 04; 17(1):25. PMID: 30832733.
      View in: PubMed
    5. Boateng BA, Indelicato N, Fischer EP, Delgado PL, Aitken ME, James LP. Beyond the common metrics: Expanding the impact of the KL2 mentored career development program using alternative impact assessment frameworks. J Clin Transl Sci. 2019 Feb; 3(1):1-4. PMID: 31404156.
      View in: PubMed
    6. Kennedy JL, Kurten RC, McCullough S, Panettieri RA, Koziol-White C, Jones SM, Caid K, Gill PS, Roberts D, Jaeschke H, McGill MR, James L. Acetaminophen is both bronchodilatory and bronchoprotective in human precision cut lung slice airways. Xenobiotica. 2019 Sep; 49(9):1106-1115. PMID: 30328361.
      View in: PubMed
    7. Stass H, Lettieri J, Vanevski KM, Willmann S, James LP, Sullivan JE, Arrieta AC, Bradley JS. Pharmacokinetics, Safety, and Tolerability of Single-Dose Intravenous Moxifloxacin in Pediatric Patients: Dose Optimization in a Phase 1 Study. J Clin Pharmacol. 2019 May; 59(5):654-667. PMID: 30681729.
      View in: PubMed
    8. Clemens MM, Kennon-McGill S, Apte U, James LP, Finck BN, McGill MR. The inhibitor of glycerol 3-phosphate acyltransferase FSG67 blunts liver regeneration after acetaminophen overdose by altering GSK3ß and Wnt/ß-catenin signaling. Food Chem Toxicol. 2019 Mar; 125:279-288. PMID: 30654094.
      View in: PubMed
    9. Shakhnovich V, Brian Smith P, Guptill JT, James LP, Collier DN, Wu H, Livingston CE, Zhao J, Kearns GL, Cohen-Wolkowiez M. A Population-Based Pharmacokinetic Model Approach to Pantoprazole Dosing for Obese Children and Adolescents. Paediatr Drugs. 2018 Oct; 20(5):483-495. PMID: 30097906.
      View in: PubMed
    10. Hutchison RD, Ford BM, Franks LN, Wilson CD, Yarbrough AL, Fujiwara R, Su MK, Fernandez D, James LP, Moran JH, Patton AL, Fantegrossi WE, Radominska-Pandya A, Prather PL. Atypical Pharmacodynamic Properties and Metabolic Profile of the Abused Synthetic Cannabinoid AB-PINACA: Potential Contribution to Pronounced Adverse Effects Relative to ?9-THC. Front Pharmacol. 2018; 9:1084. PMID: 30319418.
      View in: PubMed
    11. McCain KR, Jones JO, Chilbert KT, Patton AL, James LP, Moran JH. Impaired Driving Associated with the Synthetic Cannabinoid 5f-Adb. J Forensic Sci Criminol. 2018 Aug; 6(1). PMID: 30956998.
      View in: PubMed
    12. Gonzalez D, James LP, Al-Uzri A, Bosheva M, Adler-Shohet FC, Mendley SR, Bradley JS, Espinosa C, Tsonkova E, Moffett K, Marquez L, Simonsen KA, Stoilov S, Boakye-Agyeman F, Jasion T, Hornik CP, Hernandez R, Benjamin DK, Cohen-Wolkowiez M. Population Pharmacokinetics and Safety of Solithromycin following Intravenous and Oral Administration in Infants, Children, and Adolescents. Antimicrob Agents Chemother. 2018 08; 62(8). PMID: 29891609.
      View in: PubMed
    13. Ganger DR, Rule J, Rakela J, Bass N, Reuben A, Stravitz RT, Sussman N, Larson AM, James L, Chiu C, Lee WM. Acute Liver Failure of Indeterminate Etiology: A Comprehensive Systematic Approach by An Expert Committee to Establish Causality. Am J Gastroenterol. 2018 09; 113(9):1319. PMID: 29946176.
      View in: PubMed
    14. McElfish PA, Long CR, Selig JP, Rowland B, Purvis RS, James L, Holland A, Felix HC, Narcisse MR. Health Research Participation, Opportunity, and Willingness Among Minority and Rural Communities of Arkansas. Clin Transl Sci. 2018 09; 11(5):487-497. PMID: 29772113.
      View in: PubMed
    15. Lutkewitte AJ, Schweitzer GG, Kennon-McGill S, Clemens MM, James LP, Jaeschke H, Finck BN, McGill MR. Lipin deactivation after acetaminophen overdose causes phosphatidic acid accumulation in liver and plasma in mice and humans and enhances liver regeneration. Food Chem Toxicol. 2018 May; 115:273-283. PMID: 29534981.
      View in: PubMed
    16. Patton AL, Seely KA, Yarbrough AL, Fantegrossi W, James LP, McCain KR, Fujiwara R, Prather PL, Moran JH, Radominska-Pandya A. Altered metabolism of synthetic cannabinoid JWH-018 by human cytochrome P450 2C9 and variants. Biochem Biophys Res Commun. 2018 04 06; 498(3):597-602. PMID: 29522717.
      View in: PubMed
    17. Shakhnovich V, Smith PB, Guptill JT, James LP, Collier DN, Wu H, Livingston CE, Zhao J, Kearns GL. Obese Children Require Lower Doses of Pantoprazole Than Nonobese Peers to Achieve Equal Systemic Drug Exposures. J Pediatr. 2018 02; 193:102-108.e1. PMID: 29389444.
      View in: PubMed
    18. Le J, Poindexter B, Sullivan JE, Laughon M, Delmore P, Blackford M, Yogev R, James LP, Melloni C, Harper B, Mitchell J, Benjamin DK, Boakye-Agyeman F, Cohen-Wolkowiez M. Comparative Analysis of Ampicillin Plasma and Dried Blood Spot Pharmacokinetics in Neonates. Ther Drug Monit. 2018 02; 40(1):103-108. PMID: 29271816.
      View in: PubMed
    19. Levada K, Guldiken N, Zhang X, Vella G, Mo FR, James LP, Haybaeck J, Kessler SM, Kiemer AK, Ott T, Hartmann D, Hüser N, Ziol M, Trautwein C, Strnad P. Hsp72 protects against liver injury via attenuation of hepatocellular death, oxidative stress, and JNK signaling. J Hepatol. 2018 05; 68(5):996-1005. PMID: 29331340.
      View in: PubMed
    20. O'Brien CE, Com G, Fowlkes J, Tang X, James LP. Peripheral quantitative computed tomography detects differences at the radius in prepubertal children with cystic fibrosis compared to healthy controls. PLoS One. 2018; 13(1):e0191013. PMID: 29324908.
      View in: PubMed
    21. Hadden KB, Prince L, James L, Holland J, Trudeau CR. Readability of Human Subjects Training Materials for Research. J Empir Res Hum Res Ethics. 2018 02; 13(1):95-100. PMID: 29243548.
      View in: PubMed
    22. Rada P, Pardo V, Mobasher MA, García-Martínez I, Ruiz L, González-Rodríguez Á, Sanchez-Ramos C, Muntané J, Alemany S, James LP, Simpson KJ, Monsalve M, Valdecantos MP, Valverde ÁM. SIRT1 Controls Acetaminophen Hepatotoxicity by Modulating Inflammation and Oxidative Stress. Antioxid Redox Signal. 2018 05 01; 28(13):1187-1208. PMID: 29084443.
      View in: PubMed
    23. Hadden KB, Prince LY, Moore TD, James LP, Holland JR, Trudeau CR. Improving readability of informed consents for research at an academic medical institution. J Clin Transl Sci. 2017 Dec; 1(6):361-365. PMID: 29707258.
      View in: PubMed
    24. Gill P, Bhattacharyya S, McCullough S, Letzig L, Mishra PJ, Luo C, Dweep H, James L. MicroRNA regulation of CYP 1A2, CYP3A4 and CYP2E1 expression in acetaminophen toxicity. Sci Rep. 2017 09 26; 7(1):12331. PMID: 28951593.
      View in: PubMed
    25. Schnackenberg LK, Sun J, Bhattacharyya S, Gill P, James LP, Beger RD. Metabolomics Analysis of Urine Samples from Children after Acetaminophen Overdose. Metabolites. 2017 Sep 06; 7(3). PMID: 28878168.
      View in: PubMed
    26. Gonzalez D, Bradley JS, Blumer J, Yogev R, Watt KM, James LP, Palazzi DL, Bhatt-Mehta V, Sullivan JE, Zhang L, Murphy J, Ussery XT, Puttagunta S, Dunne MW, Cohen-Wolkowiez M. Dalbavancin Pharmacokinetics and Safety in Children 3 Months to 11 Years of Age. Pediatr Infect Dis J. 2017 07; 36(7):645-653. PMID: 28060045.
      View in: PubMed
    27. Court MH, Zhu Z, Masse G, Duan SX, James LP, Harmatz JS, Greenblatt DJ. Race, Gender, and Genetic Polymorphism Contribute to Variability in Acetaminophen Pharmacokinetics, Metabolism, and Protein-Adduct Concentrations in Healthy African-American and European-American Volunteers. J Pharmacol Exp Ther. 2017 09; 362(3):431-440. PMID: 28663312.
      View in: PubMed
    28. Banerjee S, Melnyk SB, Krager KJ, Aykin-Burns N, McCullough SS, James LP, Hinson JA. Trifluoperazine inhibits acetaminophen-induced hepatotoxicity and hepatic reactive nitrogen formation in mice and in freshly isolated hepatocytes. Toxicol Rep. 2017; 4:134-142. PMID: 28503408.
      View in: PubMed
    29. Roberts DW, Lee WM, Hinson JA, Bai S, Swearingen CJ, Stravitz RT, Reuben A, Letzig L, Simpson PM, Rule J, Fontana RJ, Ganger D, Reddy KR, Liou I, Fix O, James LP. An Immunoassay to Rapidly Measure Acetaminophen Protein Adducts Accurately Identifies Patients With Acute Liver Injury or Failure. Clin Gastroenterol Hepatol. 2017 Apr; 15(4):555-562.e3. PMID: 27641661.
      View in: PubMed
    30. Bhattacharyya S, Pence L, Yan K, Gill P, Luo C, Letzig LG, Simpson PM, Kearns GL, Beger RD, James LP. Targeted metabolomic profiling indicates structure-based perturbations in serum phospholipids in children with acetaminophen overdose. Toxicol Rep. 2016; 3:747-755. PMID: 28959601.
      View in: PubMed
    31. Dobson NR, Liu X, Rhein LM, Darnall RA, Corwin MJ, McEntire BL, Ward RM, James LP, Sherwin CM, Heeren TC, Hunt CE. Salivary caffeine concentrations are comparable to plasma concentrations in preterm infants receiving extended caffeine therapy. Br J Clin Pharmacol. 2016 09; 82(3):754-61. PMID: 27145974.
      View in: PubMed
    32. Gonzalez D, Palazzi DL, Bhattacharya-Mithal L, Al-Uzri A, James LP, Bradley J, Neu N, Jasion T, Hornik CP, Smith PB, Benjamin DK, Keedy K, Fernandes P, Cohen-Wolkowiez M. Solithromycin Pharmacokinetics in Plasma and Dried Blood Spots and Safety in Adolescents. Antimicrob Agents Chemother. 2016 Apr; 60(4):2572-6. PMID: 26883693.
      View in: PubMed
    33. Cho NE, Bang BR, Gurung P, Li M, Clemens DL, Underhill TM, James LP, Chase JR, Saito T. Retinoid regulation of antiviral innate immunity in hepatocytes. Hepatology. 2016 06; 63(6):1783-95. PMID: 26638120.
      View in: PubMed
    34. Banerjee S, Melnyk SB, Krager KJ, Aykin-Burns N, Letzig LG, James LP, Hinson JA. The neuronal nitric oxide synthase inhibitor NANT blocks acetaminophen toxicity and protein nitration in freshly isolated hepatocytes. Free Radic Biol Med. 2015 Dec; 89:750-7. PMID: 26454079.
      View in: PubMed
    35. Redwine KM, James LP, O'Riordan M, Sullivan JE, Blumer JL. Accuracy of the Spacelabs 90217 ambulatory blood pressure monitor in a pediatric population. Blood Press Monit. 2015 Oct; 20(5):295-8. PMID: 26529437.
      View in: PubMed
    36. Hartman JH, Letzig LG, Roberts DW, James LP, Fifer EK, Miller GP. Cooperativity in CYP2E1 metabolism of acetaminophen and styrene mixtures. Biochem Pharmacol. 2015 Oct 01; 97(3):341-9. PMID: 26225832.
      View in: PubMed
    37. James L, Yan K, Pence L, Simpson P, Bhattacharyya S, Gill P, Letzig L, Kearns G, Beger R. Comparison of Bile Acids and Acetaminophen Protein Adducts in Children and Adolescents with Acetaminophen Toxicity. PLoS One. 2015; 10(7):e0131010. PMID: 26208104.
      View in: PubMed
    38. Guldiken N, Zhou Q, Kucukoglu O, Rehm M, Levada K, Gross A, Kwan R, James LP, Trautwein C, Omary MB, Strnad P. Human keratin 8 variants promote mouse acetaminophen hepatotoxicity coupled with c-jun amino-terminal kinase activation and protein adduct formation. Hepatology. 2015 Sep; 62(3):876-86. PMID: 25963979.
      View in: PubMed
    39. Alonso EM, James LP, Zhang S, Squires RH. Acetaminophen Adducts Detected in Serum of Pediatric Patients With Acute Liver Failure. J Pediatr Gastroenterol Nutr. 2015 Jul; 61(1):102-7. PMID: 25859823.
      View in: PubMed
    40. Miyakawa K, Albee R, Letzig LG, Lehner AF, Scott MA, Buchweitz JP, James LP, Ganey PE, Roth RA. A Cytochrome P450-Independent Mechanism of Acetaminophen-Induced Injury in Cultured Mouse Hepatocytes. J Pharmacol Exp Ther. 2015 Aug; 354(2):230-7. PMID: 26065700.
      View in: PubMed
    41. Beger RD, Bhattacharyya S, Yang X, Gill PS, Schnackenberg LK, Sun J, James LP. Translational biomarkers of acetaminophen-induced acute liver injury. Arch Toxicol. 2015 Sep; 89(9):1497-522. PMID: 25983262.
      View in: PubMed
    42. Yang X, Salminen WF, Shi Q, Greenhaw J, Gill PS, Bhattacharyya S, Beger RD, Mendrick DL, Mattes WB, James LP. Potential of extracellular microRNAs as biomarkers of acetaminophen toxicity in children. Toxicol Appl Pharmacol. 2015 Apr 15; 284(2):180-7. PMID: 25708609.
      View in: PubMed
    43. Mobasher MA, de Toro-Martín J, González-Rodríguez Á, Ramos S, Letzig LG, James LP, Muntané J, Álvarez C, Valverde ÁM. Essential role of protein-tyrosine phosphatase 1B in the modulation of insulin signaling by acetaminophen in hepatocytes. J Biol Chem. 2014 Oct 17; 289(42):29406-19. PMID: 25204659.
      View in: PubMed
    44. Getachew Y, Cusimano FA, James LP, Thiele DL. The role of intrahepatic CD3+/CD4-/CD8- double negative T (DN T) cells in enhanced acetaminophen toxicity. Toxicol Appl Pharmacol. 2014 Oct 15; 280(2):264-71. PMID: 25168425.
      View in: PubMed
    45. James L, Roberts D. Isoniazid hepatotoxicity: progress in understanding the immunologic component. Hepatology. 2014 Mar; 59(3):746-8. PMID: 24037911.
      View in: PubMed
    46. Patton AL, Seely KA, Pulla S, Rusch NJ, Moran CL, Fantegrossi WE, Knight LD, Marraffa JM, Kennedy PD, James LP, Endres GW, Moran JH. Quantitative measurement of acetyl fentanyl and acetyl norfentanyl in human urine by LC-MS/MS. Anal Chem. 2014 Feb 04; 86(3):1760-6. PMID: 24354295.
      View in: PubMed
    47. Bhattacharyya S, Yan K, Pence L, Simpson PM, Gill P, Letzig LG, Beger RD, Sullivan JE, Kearns GL, Reed MD, Marshall JD, Van Den Anker JN, James LP. Targeted liquid chromatography-mass spectrometry analysis of serum acylcarnitines in acetaminophen toxicity in children. Biomark Med. 2014; 8(2):147-59. PMID: 24521011.
      View in: PubMed
    48. James LP. Metabolomics: integration of a new "omics" with clinical pharmacology. Clin Pharmacol Ther. 2013 Nov; 94(5):547-51. PMID: 24145711.
      View in: PubMed
    49. Seely KA, Patton AL, Moran CL, Womack ML, Prather PL, Fantegrossi WE, Radominska-Pandya A, Endres GW, Channell KB, Smith NH, McCain KR, James LP, Moran JH. Forensic investigation of K2, Spice, and "bath salt" commercial preparations: a three-year study of new designer drug products containing synthetic cannabinoid, stimulant, and hallucinogenic compounds. Forensic Sci Int. 2013 Dec 10; 233(1-3):416-22. PMID: 24314548.
      View in: PubMed
    50. Patton AL, Seely KA, Chimalakonda KC, Tran JP, Trass M, Miranda A, Fantegrossi WE, Kennedy PD, Dobrowolski P, Radominska-Pandya A, McCain KR, James LP, Endres GW, Moran JH. Targeted metabolomic approach for assessing human synthetic cannabinoid exposure and pharmacology. Anal Chem. 2013 Oct 01; 85(19):9390-9. PMID: 23987522.
      View in: PubMed
    51. Bhattacharyya S, Pence L, Beger R, Chaudhuri S, McCullough S, Yan K, Simpson P, Hennings L, Hinson J, James L. Acylcarnitine profiles in acetaminophen toxicity in the mouse: comparison to toxicity, metabolism and hepatocyte regeneration. Metabolites. 2013 Aug 02; 3(3):606-22. PMID: 24958141.
      View in: PubMed
    52. James LP, Gill P, Simpson P. Predicting risk in patients with acetaminophen overdose. Expert Rev Gastroenterol Hepatol. 2013 Aug; 7(6):509-12. PMID: 23984999.
      View in: PubMed
    53. Patton AL, Chimalakonda KC, Moran CL, McCain KR, Radominska-Pandya A, James LP, Kokes C, Moran JH. K2 toxicity: fatal case of psychiatric complications following AM2201 exposure. J Forensic Sci. 2013 Nov; 58(6):1676-80. PMID: 23822805.
      View in: PubMed
    54. Levi MS, Patton RE, Hanig JP, Tranter KM, George NI, James LP, Davis KJ, Bowyer JF. Serum myoglobin, but not lipopolysaccharides, is predictive of AMPH-induced striatal neurotoxicity. Neurotoxicology. 2013 Jul; 37:40-50. PMID: 23608161.
      View in: PubMed
    55. Abdel-Rahman SM, Paul IM, James LP, Lewandowski A. Evaluation of the Mercy TAPE: performance against the standard for pediatric weight estimation. Ann Emerg Med. 2013 Oct; 62(4):332-339.e6. PMID: 23602655.
      View in: PubMed
    56. Chimalakonda KC, James LP, Radominska-Pandya A, Moran JH. Sulfaphenazole and a-naphthoflavone attenuate the metabolism of the synthetic cannabinoids JWH-018 and AM2201 found in K2/spice. Drug Metab Lett. 2013 Mar; 7(1):34-8. PMID: 24329780.
      View in: PubMed
    57. Patton AL, Chimalakonda KC, Moran CL, McCain KR, Radominska-Pandya A, James LP, Kokes C, Moran JH. K@ toxicity: fatal case of psychiatric complications following AM2201 exposure. J Forensic Sci. 2013; EPUB ahead of print.
    58. Seely KA, Patton AL, Moran CL, Womack ML, Prather PL, Fantegrossi WE, Radominska-Pandya A, Channell KB, Endres GW, Smith NH, McCain KR, James LP, Moran JH. Forensic investigation of K2, Spice, and "bath salt" commercial preparations: A three-year study. Forensic Science International. 2013; (Submitted).
    59. Bhattacharyya S, Pence L, Beger R, Chaudhuri S, McCullough S, Yan K, Simpson P, Hennings L, Hinson J, James L. Acylcarnitine profiles in acetaminophen toxicity in the mouse: comparison to toxicity, metabolism and hepatocyte regeneration. MDPI. 2013; 3:606-622.
    60. Mazer-Amirshahi MA, Reid N, Clancy C, James LP, Van Den Anker J. Elevated acetaminophen concentration measured after nasal insufflation of Percocet. JEM. 2013.
    61. Mobasher MA, Gonzalez-Rodriguez A, Santamaria B, Ramos S, Martin MA, Goya L, Rada P, Letzig L, James LP, Cuadrado A, Martin-Perez J, Simpson KJ, Muntane J, Valverde AM. Protein tyrosine phosphatase 1B modulates GSK3ß/Nrf2 and IGFIR signaling pathways in acetaminophen-induced hepatotoxicity. Cell Death and Disease. 2013; 4:e626.
    62. Fukuda T, Goebel J, Cox S, Maseck D, Zhang K, Sherbotie JR, Ellis EN, James LP, Ward RM, Vinks AA. UGT1A9, UGT2B7, and MRP2 genotypes can predict mycophenolic acid pharmacokinetic variability in pediatric kidney transplant recipients. Ther Drug Monit. 2012 Dec; 34(6):671-9. PMID: 23131697.
      View in: PubMed
    63. Kelkar M, Cleves MA, Foster HR, Hogan WR, James LP, Martin BC. Prescription-acquired acetaminophen use and the risk of asthma in adults: a case-control study. Ann Pharmacother. 2012 Dec; 46(12):1598-608. PMID: 23170033.
      View in: PubMed
    64. James LP, Chiew A, Abdel-Rahman SM, Letzig L, Graudins A, Day P, Roberts D. Acetaminophen protein adduct formation following low-dose acetaminophen exposure: comparison of immediate-release vs extended-release formulations. Eur J Clin Pharmacol. 2013 Apr; 69(4):851-7. PMID: 23052410.
      View in: PubMed
    65. Chimalakonda KC, Seely KA, Bratton SM, Brents LK, Moran CL, Endres GW, James LP, Hollenberg PF, Prather PL, Radominska-Pandya A, Moran JH. Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2/Spice: identification of novel cannabinoid receptor ligands. Drug Metab Dispos. 2012 Nov; 40(11):2174-84. PMID: 22904561.
      View in: PubMed
    66. Chaudhuri S, McCullough SS, Hennings L, Brown AT, Li SH, Simpson PM, Hinson JA, James LP. Effect of trifluoperazine on toxicity, HIF-1a induction and hepatocyte regeneration in acetaminophen toxicity in mice. Toxicol Appl Pharmacol. 2012 Oct 15; 264(2):192-201. PMID: 22902588.
      View in: PubMed
    67. Cohen-Wolkowiez M, Benjamin DK, Ross A, James LP, Sullivan JE, Walsh MC, Zadell A, Newman N, White NR, Kashuba AD, Ouellet D. Population pharmacokinetics of piperacillin using scavenged samples from preterm infants. Ther Drug Monit. 2012 Jun; 34(3):312-9. PMID: 22569355.
      View in: PubMed
    68. Redwine K, Howard L, Simpson P, Li SH, Yan K, James L, Blumer J, Sullivan J, Ward R, Wells T. Effect of placebo on ambulatory blood pressure monitoring in children. Pediatr Nephrol. 2012 Oct; 27(10):1937-42. PMID: 22623022.
      View in: PubMed
    69. Myers AL, Gaedigk A, Dai H, James LP, Jones BL, Neville KA. Defining risk factors for red man syndrome in children and adults. Pediatr Infect Dis J. 2012 May; 31(5):464-8. PMID: 22327873.
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    70. Bhutta AT, Schmitz ML, Swearingen C, James LP, Wardbegnoche WL, Lindquist DM, Glasier CM, Tuzcu V, Prodhan P, Dyamenahalli U, Imamura M, Jaquiss RD, Anand KJ. Ketamine as a neuroprotective and anti-inflammatory agent in children undergoing surgery on cardiopulmonary bypass: a pilot randomized, double-blind, placebo-controlled trial. Pediatr Crit Care Med. 2012 May; 13(3):328-37. PMID: 21926656.
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    71. Mian A, Becton D, Saylors R, James L, Tang X, Bhutta A, Prodhan P. Biomarkers for risk stratification of febrile neutropenia among children with malignancy: a pilot study. Pediatr Blood Cancer. 2012 Aug; 59(2):238-45. PMID: 22535591.
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    72. Farrar HC, Grayham T, Bolden B, Vyas D, Graham J, James LP. The use and tolerability of Crotalidae Polyvalent Immune FAB (Ovine) in pediatric envenomations. Clin Pediatr (Phila). 2012 Oct; 51(10):945-9. PMID: 22511193.
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    73. Kelkar M, Cleves MA, Foster HR, Hogan WR, James LP, Martin BC. Acute and chronic acetaminophen use and renal disease: a case-control study using pharmacy and medical claims. J Manag Care Pharm. 2012 Apr; 18(3):234-46. PMID: 22468732.
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    74. Cohen-Wolkowiez M, Ouellet D, Smith PB, James LP, Ross A, Sullivan JE, Walsh MC, Zadell A, Newman N, White NR, Kashuba AD, Benjamin DK. Population pharmacokinetics of metronidazole evaluated using scavenged samples from preterm infants. Antimicrob Agents Chemother. 2012 Apr; 56(4):1828-37. PMID: 22252819.
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    75. Fukuda T, Goebel J, Cox S, Maseck D, Zhang K, Sherbotie JR, Ellis En, James LP, Ward RM, Vinks AA. UGT1A9, UGTB7, and MRP2 genotypes can predict mycophenolic acid pharmacokinetic variability in pediatric kidney transplant recipients. Ther Drug Monit. 2012; 34(6):671-79.
    76. Paine M, Chimalakonda KC, Seely KA, Bratton SM, Brents LK, Moran CL, Endres GW, James LP, Hollenberg PF, Prather PL, Radominska-Pandya A, Moran JH. P450-mediated oxidative metabolism of abused synthetic cannabinoids found in “K2/Spice”: identification of novel cannabinoid receptor ligands. Drug Metab Dispos. 2012; 40(11):2174-84.
    77. Chaudhuri S, McCullough SS, Hennings L, Brown AT, Li Sh, Simpson PM, Hinson JA, James LP. Effects of trifluoperazine on toxicity, HIF-1 induction and hepatocyte regeneration in acetaminophen toxicity in mice. Toxicology and Applied Pharmacology. 2012; 264(2):192-201.
    78. Prodhan P, Bhutta AT, Saylors RL, Becton DL, James LP, Tang X, Mian A. Biomarkers predictive of clinical outcome for fever-neutropenia in children with cancer. Pediatric Blood & Cancer. 2012; 59(2):238-45.
    79. Milesi-Hallé A, McCullough S, Hinson JA, Kurten RC, Lamps LW, Brown A, James LP. Echinomycin decreases induction of vascular endothelial growth factor and hepatocyte regeneration in acetaminophen toxicity in mice. Basic Clin Pharmacol Toxicol. 2012 Apr; 110(4):327-34. PMID: 21985601.
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    80. Brown AT, Ou X, James LP, Jambhekar K, Pandey T, McCullough S, Chaudhuri S, Borrelli MJ. Correlation of MRI findings to histology of acetaminophen toxicity in the mouse. Magn Reson Imaging. 2012 Feb; 30(2):283-9. PMID: 22055850.
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    81. James L, Sullivan JE, Roberts D. The proper use of acetaminophen. Paediatr Child Health. 2011 Nov; 16(9):544-7. PMID: 23115492.
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    82. Agarwal R, Hennings L, Rafferty TM, Letzig LG, McCullough S, James LP, MacMillan-Crow LA, Hinson JA. Acetaminophen-induced hepatotoxicity and protein nitration in neuronal nitric-oxide synthase knockout mice. J Pharmacol Exp Ther. 2012 Jan; 340(1):134-42. PMID: 22001257.
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    83. Chimalakonda KC, Moran CL, Kennedy PD, Endres GW, Uzieblo A, Dobrowolski PJ, Fifer EK, Lapoint J, Nelson LS, Hoffman RS, James LP, Radominska-Pandya A, Moran JH. Solid-phase extraction and quantitative measurement of omega and omega-1 metabolites of JWH-018 and JWH-073 in human urine. Anal Chem. 2011 Aug 15; 83(16):6381-8. PMID: 21740038.
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    84. Chimalakonda KC, Bratton SM, Le VH, Yiew KH, Dineva A, Moran CL, James LP, Moran JH, Radominska-Pandya A. Conjugation of synthetic cannabinoids JWH-018 and JWH-073, metabolites by human UDP-glucuronosyltransferases. Drug Metab Dispos. 2011 Oct; 39(10):1967-76. PMID: 21746969.
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    85. Moran CL, Le VH, Chimalakonda KC, Smedley AL, Lackey FD, Owen SN, Kennedy PD, Endres GW, Ciske FL, Kramer JB, Kornilov AM, Bratton LD, Dobrowolski PJ, Wessinger WD, Fantegrossi WE, Prather PL, James LP, Radominska-Pandya A, Moran JH. Quantitative measurement of JWH-018 and JWH-073 metabolites excreted in human urine. Anal Chem. 2011 Jun 01; 83(11):4228-36. PMID: 21506519.
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    86. Ceelie I, James LP, Gijsen V, Mathot RA, Ito S, Tesselaar CD, Tibboel D, Koren G, de Wildt SN. Acute liver failure after recommended doses of acetaminophen in patients with myopathies. Crit Care Med. 2011 Apr; 39(4):678-82. PMID: 21242792.
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    87. Heard KJ, Green JL, James LP, Judge BS, Zolot L, Rhyee S, Dart RC. Acetaminophen-cysteine adducts during therapeutic dosing and following overdose. BMC Gastroenterol. 2011 Mar 14; 11:20. PMID: 21401949.
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    88. Hubbard JJ, James LP. Complications and outcomes of brown recluse spider bites in children. Clin Pediatr (Phila). 2011 Mar; 50(3):252-8. PMID: 21307081.
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    89. Farst K, Reading Meyer JA, Mac Bird T, James L, Robbins JM. Hair drug testing of children suspected of exposure to the manufacture of methamphetamine. J Forensic Leg Med. 2011 Apr; 18(3):110-4. PMID: 21420647.
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    90. Chaudhuri S, McCullough SS, Hennings L, Letzig L, Simpson PM, Hinson JA, James LP. Acetaminophen hepatotoxicity and HIF-1a induction in acetaminophen toxicity in mice occurs without hypoxia. Toxicol Appl Pharmacol. 2011 May 01; 252(3):211-20. PMID: 21316383.
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    91. Seely KA, Prather PL, James LP, Moran JH. Marijuana-based drugs: innovative therapeutics or designer drugs of abuse? Mol Interv. 2011 Feb; 11(1):36-51. PMID: 21441120.
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    92. Khandelwal N, James LP, Sanders C, Larson AM, Lee WM. Unrecognized acetaminophen toxicity as a cause of indeterminate acute liver failure. Hepatology. 2011 Feb; 53(2):567-76. PMID: 21274877.
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    93. Seely KA, Prather PL, James LP, Moran JH. marijuana-based drugs: Innovateive therapeutics or designer drugs of abuse. Molecular Interventions. 2011; 11(1):36-51.
    94. Radominska-Pandya A, Chimalakonda K, Bratton SM, Vi-Huyen L, Yiew K, James LP, Moran JH. Conjugation of JWH-018 and JWH-073 metabolites by human UDP-glucuronosyltransferases. Drug Metab Dispos. 2011; 39(10):1967-76.
    95. T Grayham, James L, F Henry, D Vyas, J Graham. The tolerability of crotalidae polyvalent immune fab in pediatric snakebite. SSPR. 2011.
    96. Lapoint J, James LP, Moran C, Nelson L, Hoffman RS, Moran J. Severe toxicity following synthetic cannabinoid ingestion. Clin Tox. 2011; 49(8):760-4.
    97. Redwine K, Howard L, Simspon P, Li SH, James L, Blumer J, Sullivan J, Ward R, Wells T. Effects of placebo on ambulatory blood pressure monitoring in children. Pediatric Academic Societies and Asian Society for Pediatric Research. 2011.
    98. Ajmera V, Xia G, Vaughan G, Forbi J, Ganova-Raeva LM, Khudyakov Y, Opio CK, Taylor R, Restrepo R, Munoz S, Fontana RJ, James LP, Lee WM, And the Acute Liver Failure Study Group. What factors determine the severity of Hepatitis A related acute liver failure?. J Viral Hepat. 2011; 1(252):211-20.
    99. Radominska-Pandya A, Bratton SM, Chib S, Blevins JM, Gallus-Zawada A, Moran C, James LP, Moran JH. Oxidation of abused synthetic cannabinoids in K2/Spice by human cytochromes P450. Experimental Biology. 2011.
    100. Moran CL, Le VH, Chimalakonda KC, Smedley AL, Lackey FD, Owen SN, Kennedy PD, Endres GW, Ciske FL, Kramer JB, Kornilov AM, Bratton LD, Dobrowolski PH, Wessinger WD, Fantegrossi WE, Prather PP, James LP, Radominski-Pandya A, Moran JH. Quantitative measurement of JWH-018 and JWH-073 metabolites excreted in human urine and identification of specific biomarkers. Analytical Chemistry. 2011; 83(11):4228-36.
    101. Heard K, Green J, James LP, Judge B, Rhyee S, Zolot L, Dart R. Acetaminophen-cystiene adducts during therapeutic dosing and following overdose. BMC Gastroenterology. 2011; 14:11-20.
    102. Chaudhuri S, McCullough SS, Hennings L, Letzig L, Simpson PM, Hinson JA, James LP. Acetaminophen hepatotoxicity and HIF-1alpha induction in mice occurs without hypoxia. Toxicol Appl Pharmacol. 2011; 252(3):211-220.
    103. Milesi-Halle A, Abdel-Rahman SM, Brown A, McCullough SS, Letzig L, Hinson JA, James LP. Indocyanin green clearance varies as a function of n-acetylcysteine treatment in a murine model of acetaminophen toxicity. Chemico Biol Interact. 2011; 189(222-229).
    104. Ward RM, Kearns GL, Tammara B, Bishop P, O'Gorman MA, James LP, Katz MH, Maguire MK, Rath N, Meng X, Comer GM. A multicenter, randomized, open-label, pharmacokinetics and safety study of Pantoprazole tablets in children and adolescents aged 6 through 16 years with GERD. J Clin Pharm. 2011; 5(6):876-87.
    105. James LP, Roberts DW, Sullivan JE. A proper use of acetaminophen. Paediatr Child Health. 2011; 16(9):544-47.
    106. Lapoint J, Moran CL, Nelson LS, Hoffman RS, Moran JH. Severe toxicity following synthetic cannabinoid ingestion. Clin Tox (Phila). 2011; 49(8):760-4.
    107. Agarwal R, MacMillan-Crow LA, Rafferty TM, Saba H, Roberts DW, Fifer EK, James LP, Hinson JA. Acetaminophen-induced hepatotoxicity in mice occurs with inhibition of activity and nitration of mitochondrial manganese superoxide dismutase. J Pharmacol Exp Ther. 2011 Apr; 337(1):110-6. PMID: 21205919.
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    108. Milesi-Hallé A, Abdel-Rahman SM, Brown A, McCullough SS, Letzig L, Hinson JA, James LP. Indocyanine green clearance varies as a function of N-acetylcysteine treatment in a murine model of acetaminophen toxicity. Chem Biol Interact. 2011 Feb 01; 189(3):222-9. PMID: 21145883.
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    109. Ward RM, Kearns GL, Tammara B, Bishop P, O'Gorman MA, James LP, Katz MH, Maguire MK, Rath N, Meng X, Comer GM. A multicenter, randomized, open-label, pharmacokinetics and safety study of pantoprazole tablets in children and adolescents aged 6 through 16 years with gastroesophageal reflux disease. J Clin Pharmacol. 2011 Jun; 51(6):876-87. PMID: 20852004.
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    110. Donahower BC, McCullough SS, Hennings L, Simpson PM, Stowe CD, Saad AG, Kurten RC, Hinson JA, James LP. Human recombinant vascular endothelial growth factor reduces necrosis and enhances hepatocyte regeneration in a mouse model of acetaminophen toxicity. J Pharmacol Exp Ther. 2010 Jul; 334(1):33-43. PMID: 20363854.
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    111. Hinson JA, Roberts DW, James LP. Mechanisms of acetaminophen-induced liver necrosis. Handb Exp Pharmacol. 2010; (196):369-405. PMID: 20020268.
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    112. Gardner A, Byrnes J, James LP, Moss M. Suspected trauma in comatose child found to be Baclofen poisoning. The Pediatric Clinical Symposium. 2010.
    113. Donahower BC, McCullough SS, Simpson PM, Lamps L, Stowe CD, Kurten R, Hinson JA, James LP. Examination of exogenous hrVEGF in a mouse model of acetaminophen toxicity. JPET. 2010; 334(1):33-43.
    114. Getachew Y, James LP, Lee WM, Thiele DL, Miller BC. Susceptibility to acetaminophen (APAP) toxicity unexpectedly is decreased during acute viral hepatitis in mice. Biochem Pharm. 2010; 79(9):1363-71.
    115. Hubbard J, James LP. Brown Recluse Spider Bite Effects and Outcomes in Children in Arkansas. First Annuan MD/PhD Graduate Student Research Symposium. 2010.
    116. O'Brien C, Lowery J, Palmer K, James L. Neonatal and Pediatric Pharmacology: Therapeutic Principles in Practice. Gastrointestinal Drugs. 2010.
    117. Ortmann LA, Jaeger MW, James LP, Schexnayder SM. Coma in a 20-month-old child from an ingestion of a toy containing 1,4-butanediol, a precursor of gamma-hydroxybutyrate. Pediatr Emerg Care. 2009 Nov; 25(11):758-60. PMID: 19915428.
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    118. Hinson JA, Roberts DW, James LP. Adverse Drug Reactions, Handbook of Experimental Pharmacology. Mechanisms of Acetaminophen-Induced Liver Necrosis. 2009; 12.
    119. James LP, Letzig L, Simpson PM, Capparelli E, Roberts DW, Hinson JA, Davern TJ, Lee WM. Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure. Drug Metab Dispos. 2009 Aug; 37(8):1779-84. PMID: 19439490.
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    120. James L, Ito S. Neonatal Pharmacology: rational therapeutics for the most vulnerable. Clin Pharmacol Ther. 2009; 86(6):573-7.
    121. Jones BL, Pearce RE, Abdel-Rahman SM, Friesen CA, James LP, Kearns GL. Characterization of delayed gastric emptying by the 13C-acetate breath test. J Breath Res. 2009; 3(4).
    122. James LP, Capparelli EV, Simpson PM, Letzig L, Roberts D, Hinson JA, Kearns GL, Blumer JL, Sullivan JE. Acetaminophen-associated hepatic injury: evaluation of acetaminophen protein adducts in children and adolescents with acetaminophen overdose. Clin Pharmacol Ther. 2008 Dec; 84(6):684-90. PMID: 18923390.
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    123. O'Brien CE, Harik N, James LP, Seib PM, Stowe CD. Cesium-induced QT-interval prolongation in an adolescent. Pharmacotherapy. 2008 Aug; 28(8):1059-65. PMID: 18657021.
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    124. Kearns GL, Blumer J, Schexnayder S, James LP, Adcock KG, Reed MD, Daniel JF, Gaedigk A, Paul J. Single-dose pharmacokinetics of oral and intravenous pantoprazole in children and adolescents. J Clin Pharmacol. 2008 Nov; 48(11):1356-65. PMID: 18664620.
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    125. O'Brien, Catherine E, Harik, Nada, James LP, Seib, Paul M, Stowe, Cindy D. Cesium-Induced QT-Interval Prolongation in Adolescent. Pharmacotherapy. 2008; 28(8):1059-1065.
    126. Hong H, Teitel C, James LP, Tong W, Hinson JA, Fuscoe JC, Dragan Y. SELDI based proteomic determination of hepatic biomarkers in mourse serum following acetaminophen administration. J of Proteomics and Bioinformatics. 2008; 1(8):424-436.
    127. Ortmann LA, Jaeger MW, Schexnayder SM, James LP. Coma in a 20-month old child from an ingestion of a toy containing 1,4-buanediol, a precursor of gamma-hydroxybutyrate. Pediatric Emergency Care. 2008; 25(11):758-60.
    128. Burke AS, Redeker K, Kurten RC, James LP, Hinson JA. Mechanisms of chloroform-induced hepatotoxicity: oxidative stress and mitochondrial permeability transition in freshly isolated mouse hepatocytes. J Toxicol Environ Health A. 2007 Nov; 70(22):1936-45. PMID: 17966065.
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    129. James L, Walson P, Lomax K, Kao R, Varughese S, Reyes J. Pharmacokinetics and tolerability of rabeprazole sodium in subjects aged 12 to 16 years with gastroesophageal reflux disease: an open-label, single- and multiple-dose study. Clin Ther. 2007 Sep; 29(9):2082-92. PMID: 18035206.
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    130. Burke AS, Redeker L, Kurten RC, James LP, HInson JA. Mechanisms of chloroform-induced hepatotoxicity: oxidative stess and mitochondrial permeability transition in freshly isolated mouse hepatocytes. J Toxic & Envirn Hlth. 2007; 70(22):1936-45.
    131. James LP, Walson P, Lomax K, Kao R, Varughese S, James LP. Pharmacokinetics and Tolerability of Rabeprazole in Patients Ages 12 to 16 years with gastroesophageal reflux disease. Clinical Therapeutics. 2007; 29(9):2082-92.
    132. Vaquero J, Belanger M, James LP, Herrero R, Desjardins P, Cote J, Blei AT, Butterworth RF. Mild hypothermia attenuates liver injury and improves survival in mice with acetaminophen toxicity. Gastroenterology. 2007; 132(1):372-83.
    133. James LP, Alonso EM, Hynan LS, Hinson JA, Davern TJ, Lee WM, Squires RH. Detection of acetaminophen protein adducts in children with acute liver failure of indeterminate cause. Pediatrics. 2006 Sep; 118(3):e676-81. PMID: 16950959.
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    134. Farst K, Duncan JM, Moss M, Ray RM, Kokoska E, James LP. Methamphetamine exposure presenting as caustic ingestions in children. Ann Emerg Med. 2007 Mar; 49(3):341-3. PMID: 17141141.
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    135. Donahower B, McCullough SS, Kurten R, Lamps LW, Simpson P, Hinson JA, James LP. Vascular endothelial growth factor and hepatocyte regeneration in acetaminophen toxicity. Am J Physiol Gastrointest Liver Physiol. 2006 Jul; 291(1):G102-9. PMID: 16565415.
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    136. James LP, Donahower B, Burke AS, McCullough S, Hinson JA. Induction of the nuclear factor HIF-1alpha in acetaminophen toxicity: evidence for oxidative stress. Biochem Biophys Res Commun. 2006 Apr 28; 343(1):171-6. PMID: 16530163.
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    137. Davern TJ, James LP, Hinson JA, Polson J, Larson AM, Fontana RJ, Lalani E, Munoz S, Shakil AO, Lee WM. Measurement of serum acetaminophen-protein adducts in patients with acute liver failure. Gastroenterology. 2006 Mar; 130(3):687-94. PMID: 16530510.
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    138. James LP, Donahower B, Burke AS, McCullough SS, Hinson JA. Induction of the neclear factor HIF-1alpha in livers of acetaminophen treated mice and freshly isolated hepatocytes: evidence for oxidative stress. Biochem and Biophys Resch Comm. 2006; 343:171-176.
    139. James LP, Alonzo E, Hynan LS, Hinson JA, Davern TJ, Lee WM, Squires RH, Pediatrics Acute Liver Failure Study Group. Detection of Acetaminophen Protein Adducts in Children with Acute Liver Failure of Indeterminate Etiology. Pediatrics. 2006; 118(3):e676-e681.
    140. James LP, Simpson PM, Farrar HC, Kearns GL, Wasserman GS, Blumer JL, Reed MD, Sullivan JE, Hinson JA. Cytokines and toxicity in acetaminophen overdose. J Clin Pharmacol. 2005 Oct; 45(10):1165-71. PMID: 16172181.
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    141. James LP, Kurten RC, Lamps LW, McCullough S, Hinson JA. Tumour necrosis factor receptor 1 and hepatocyte regeneration in acetaminophen toxicity: a kinetic study of proliferating cell nuclear antigen and cytokine expression. Basic Clin Pharmacol Toxicol. 2005 Jul; 97(1):8-14. PMID: 15943753.
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    142. Wenning LA, Murphy MG, James LP, Blumer JL, Marshall JD, Baier J, Scheimann AO, Panebianco DL, Zhong L, Eisenhandler R, Yeh KC, Kearns GL. Pharmacokinetics of famotidine in infants. Clin Pharmacokinet. 2005; 44(4):395-406. PMID: 15828852.
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    143. James LP, Kurten RC, Lamps LW, McCullough SS, Hinson JA. Tumor Necrosis Factor Receptor 1 and Hepatocyte Regeneration in Acetaminophen Toxicity: A Kinetic Study of Proliferating Cell Nuclear Antigen and Cytoline Expression. Basic Clin Pharm & Tox. 2005; 97(1):8-14.
    144. Wenning LA, Murphy GM, James LP, Blumer JL, Marshall JD, Baier J, Scheimann AO, Panebianco DL, Zhong L, Eisenhandler R, Yeh KC, Kearns GL. Pharmacokinetics of famotidine in infants less than 1 year of age. Clin Pharm. 2005; 44(3):395-406.
    145. Hinson JA, Reid AB, McCullough SS, James LP. Acetaminophen-induced hepatotoxicity: role of metabolic activation, reactive oxygen/nitrogen species, and mitochondrial permeability transition. Drug Metab Rev. 2004 Oct; 36(3-4):805-22. PMID: 15554248.
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    146. James LP, Simpson PM, Farrar HC, Wasserman G, Kearns GL, Hinson JA. Correlation of MCP1 with toxicity in acetaminophen overdose. J Ark Med Soc. 2004 Jun; 100(12):424-5. PMID: 15200281.
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    147. Palmer KG, James LP. Methemoglobinemia associated with metoclopramide therapy in a neonate. J Pediatr Pharmacol Ther. 2004 Jan; 9(1):49-54. PMID: 23118691.
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    148. James LP, Farrar HC, Palmer K, Kearns GL. Pediatric and Neonatal Pharmacology. Gastrointestinal Drugs. 2004.
    149. Sheffield LJ, Wood JM, James LP, Roche J, Chalkiadis G, Venter JD, Pitt J, Davidson A, Cranswick N. CYP1A2*1F allele predicts risk of liver toxicity in children prescribed acetaminophen following surgery. Presented to The American Society of Human Genetics. 2004.
    150. James LP, McCullough SS, Knight TR, Jaeschke H, Hinson JA. Acetaminophen toxicity in mice lacking NADPH oxidase activity: role of peroxynitrite formation and mitochondrial oxidant stress. Free Radic Res. 2003 Dec; 37(12):1289-97. PMID: 14753753.
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    151. James LP, Mayeux PR, Hinson JA. Acetaminophen-induced hepatotoxicity. Drug Metab Dispos. 2003 Dec; 31(12):1499-506. PMID: 14625346.
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    152. James LP. Efficacy and safety measurements of proton pump inhibitors in infants and children. J Pediatr Gastroenterol Nutr. 2003 Nov-Dec; 37 Suppl 1:S46-51. PMID: 14685078.
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    153. James LP, Lamps LW, McCullough S, Hinson JA. Interleukin 6 and hepatocyte regeneration in acetaminophen toxicity in the mouse. Biochem Biophys Res Commun. 2003 Oct 03; 309(4):857-63. PMID: 13679052.
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    154. Kearns GL, Andersson T, James LP, Gaedigk A, Kraynak RA, Abdel-Rahman SM, Ramabadran K, van den Anker JN. Omeprazole disposition in children following single-dose administration. J Clin Pharmacol. 2003 Aug; 43(8):840-8. PMID: 12953341.
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    155. James LP, McCullough SS, Lamps LW, Hinson JA. Effect of N-acetylcysteine on acetaminophen toxicity in mice: relationship to reactive nitrogen and cytokine formation. Toxicol Sci. 2003 Oct; 75(2):458-67. PMID: 12883092.
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    156. Fahr MJ, James LP, Beck JR, James CA. Digital radiography in the diagnosis of Toddler's fracture. South Med J. 2003 Mar; 96(3):234-9. PMID: 12659353.
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    157. Maples HD, James LP, Stowe CD, Jones DP, Hak EB, Blumer JL, Vogt B, Wilson JT, Kearns GL, Wells TG. Famotidine disposition in children and adolescents with chronic renal insufficiency. J Clin Pharmacol. 2003 Jan; 43(1):7-14. PMID: 12520622.
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    158. Kearns GL, Andersson T, James LP, Li BUK, Gaedigk A, Kraynak RA, Ramabadran K, Abdel-Rahman SM, Van den Anker JN. Omeprazole Disposition In Children Following Single-Dose Administration: Relationship to CYP2C19 Genotype. J Clin Pharm. 2003; 43:840-848.
    159. Maples HD, James LP, Stowe CD, Jones DP, Hak EB, Blumer JL, Vogt B, Wilson JT, Kearns GL, Wells TG, Network of Pediatric Pharmacology Research Units (NICHD). Famotidine Dispostion in Children and Adolscents with Chronic Renal Insufficiency. J Clin Pharm. 2003; 43:7-14.
    160. Fahr MJ, James LP, Beck JR, James CA. Digital Assessment of Occult Toddler's Fractures. So Med J. 2003; 96(2):1-6.
    161. James LP, Wells E, Beard RH, Farrar HC. Predictors of outcome after acetaminophen poisoning in children and adolescents. J Pediatr. 2002 May; 140(5):522-6. PMID: 12032516.
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    162. Muldrew KL, James LP, Coop L, McCullough SS, Hendrickson HP, Hinson JA, Mayeux PR. Determination of acetaminophen-protein adducts in mouse liver and serum and human serum after hepatotoxic doses of acetaminophen using high-performance liquid chromatography with electrochemical detection. Drug Metab Dispos. 2002 Apr; 30(4):446-51. PMID: 11901099.
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    163. James LP. Pharmacology for the gastrointestinal tract. Clin Perinatol. 2002 Mar; 29(1):115-33. PMID: 11917734.
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    164. Ferron GM, James LP, Kearns GL, Blumer J, Abell M, Mayer PR, Getsy J, Paul J. Pharmacokinetics of oral pantoprazole in pediatric patients. Presented to The American College of Clinical Pharmacy. 2002; 1358.
    165. James LP, Abdel-Rahmen S, Farrar HC, Jacobs RF. Principals and Practice of Pediatric Infectious Disease. Antimicrogial Agents. 2002.
    166. James LP, Simpson P, Farrar H, Casavant M, Van de Anker J, Wasserman G, Kearns G. Elevation of Cytokines in acetaminophen overdose. Presented to The American Academy of Clinical Toxicology. 2002; 599.
    167. James LP. Neonatal Gastroenterology Clinics in Perinatology. Pharmacology for the GI Tract. 2002.
    168. James LP, Beard R, Wells E, Farrar HC. Predictions of outcome following acetaminophen poisoning in children and adolscents. J Peds. 2002; 140(5):522-526.
    169. James LP, Farrar HC, Darville TL, Sullivan JE, Givens TG, Kearns GL, Wasserman GS, Simpson PM, Hinson JA. Elevation of serum interleukin 8 levels in acetaminophen overdose in children and adolescents. Clin Pharmacol Ther. 2001 Sep; 70(3):280-6. PMID: 11557916.
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    170. James LP, Farrar HC, Sullivan JE, Givens TG, Kearns GL, Wasserman GS, Walson PD, Hinson JA, Pumford NR. Measurement of acetaminophen-protein adducts in children and adolescents with acetaminophen overdoses. . J Clin Pharmacol. 2001 Aug; 41(8):846-51. PMID: 11504272.
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    171. James LP, Wilson JT, Simar R, Farrar HC, Kearns GL, Simpson PM, Hinson JA, Pumford NR. Evaluation of occult acetaminophen hepatotoxicity in hospitalized children receiving acetaminophen. Pediatric Pharmacology Research Unit Network. Clin Pediatr (Phila). 2001 May; 40(5):243-8. PMID: 11388672.
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    172. James LP, Wilson JT, Simar R, Farrar HC, Kearns GL, Hinson JA, Pumford NR. Evaluation of occult acetaminophen hepatotoxicity in hospitalized children receiving acetaminophen. Clin Ped. 2001; 40(5):243-248.
    173. James LP, Farrar HC, Darville TL, Sullivan JE, Givens TG, Kearns GL, Wasserman GS, Simpson PM, HInson JA. Elevation of serum interleukin-8 in acetaminophen overdose in children and adolescents. Clin Pharm Ther. 2001; 70(3):280-286.
    174. Kearns GL, Abdel-Tahman SM, Blumer JL, Reed MD, James LP, Jacobs RF, Weldhman IR, Jungbluth GL, Stalker DJ. Single dose pharmacolkinetics of linezolid in infants and children. Ped Inf Dis Jour. 2000; 19:1178-84.
    175. Kearns GL, Bradley JS, Jacobs RF, Capparelli E, James LP, Johnson KM, Abdel-Rahman SM. Single dose pharmacokinetics of pleconaril in neonates. Ped Inf Dis Jour. 2000; 19:833-839.
    176. Stowe CD, Bollinger T, James LP, Haley TM, Griebel ML, Farrar HC. Acute mental status changes and hyperchloremic metabolic acidosis with long-term topiramate therapy. Pharmacotherapy. 2000 Jan; 20(1):105-9. PMID: 10641984.
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    177. James LP, Abel K, Wilkinson J, Simpson PM, Nichols MH. Phenothiazine, butyrophenone, and other psychotropic medication poisonings in children and adolescents. J Toxicol Clin Toxicol. 2000; 38(6):615-23. PMID: 11185968.
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    178. James LP, Stowe CD, Argao E. Gastric injury following copper sulfate ingestion. Pediatr Emerg Care. 1999 Dec; 15(6):429-31. PMID: 10608335.
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    179. James LP, Stowe CD, Farrar HC, Menendez AA, Argao EA. The pharmacokinetics of oral ranitidine in children and adolescents with cystic fibrosis. J Clin Pharmacol. 1999 Dec; 39(12):1242-7. PMID: 10586389.
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    180. Farrar, HC, James LP. Characteristics of pediatric admissions for cyclic antidepressant poisoning. Am J Emrg Med. 1999; 17(5):495-496.
    181. Kearns GL, Abdel-Rahman SM, James LP, Blowey DL, Marshall JD, Wells TG, Jacobs RF. Single-dose pharmacokinetics of a pleconaril (VP63843) oral solution in children and adolescents. Antimicrobial Agents and Chemotherapy. 1999; 43(3):634-638.
    182. James LP, Marotti T, Stowe CD, Farrar HC, Taylor BJ, Kearns GL. Pharmacokinetics and pharmacodynamics of famotidine in infants. J Clin Pharmacol. 1998 Dec; 38(12):1089-95. PMID: 11301560.
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    183. Schexnayder S, James LP, Kearns GL, Farrar HC. The pharmacokinetics of continuous infusion pralidoxime in children with organophosphate poisoning. J Toxicol Clin Toxicol. 1998; 36(6):549-55. PMID: 9776957.
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    184. James LP, Farrar HC, Komoroski EM, Wood WR, Graham CJ, Bornemeier RA, Valentine JL. Sympathomimetic drug use in adolescents presenting to a pediatric emergency department with chest pain. J Toxicol Clin Toxicol. 1998; 36(4):321-8. PMID: 9711198.
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    185. James LP, Farrar HC, Komoroski EM, Wood WR, Graham CJ, Bornemeier RA, Valentine JL. Sympathormimetic drug use in adolescents presenting to a pediatric emergency department with chrest pain. Clin Tox. 1998; 36(4):321-328.
    186. Schexnayder S, James LP, Kearns GL, Farrar HC. The pharmacokinetics of continuous infusion pralidoxime in children with organophosphate. Clin Tox. 1998; 36(6):459-555.
    187. Fant JS, James LP, Fiser RT, Kearns GL. The use of glucagon in nifedipine poisoning complicated by clonidine ingestion. Pediatr Emerg Care. 1997 Dec; 13(6):417-9. PMID: 9435007.
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    188. James LP, Farrar HC, Griebel ML, Bates SR. Bromism: intoxication from a rare anticonvulsant therapy. Pediatr Emerg Care. 1997 Aug; 13(4):268-70. PMID: 9291516.
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    189. Nichols MH, King WD, James LP. Clonidine Poisoning in Jefferson County, Alabama. Anul Emerg Med. 1997; 29:511-517.
    190. James LP, Kearns GL. Pharmacokinetics and pharmacodynamics of famotidine in paediatric patients. Clin Pharmacokinet. 1996 Aug; 31(2):103-10. PMID: 8853932.
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    191. James LP, Marshall JD, Heulitt MJ, Wells TG, Letzig L, Kearns GL. Pharmacokinetics and pharmacodynamics of famotidine in children. J Clin Pharmacol. 1996 Jan; 36(1):48-54. PMID: 8932543.
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    192. James LP, King WD. Piercing injury hospitalization in children. Pediatric Emerceny Care. 1996; 12(2):84-86.
    193. James LP, Kearns GL. Cyclic antidepressant toxicity in children and adolescents. J Clin Pharmacol. 1995 Apr; 35(4):343-50. PMID: 7650221.
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    194. James LP, Nichols MH, King WD. Herbs and HIV: the health food industry's answer. Sthn Med Jour. 1995; 88(9):911-913.
    195. Genuardi FJ, King WD, James LP. Outcome of injury-related hospitalizations among youth athletes. Archives of Pediatrics and Adol Med. 1995; 149:1037-1039.
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