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Laura James

CredentialsMD
TitleProfessor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPeds Pediatrics, College of Medicine
DivisionPeds Emergency Medicine
AddressS3117 ACH Sturgis Building
800 Marshall Street
Mail Slot # 512
Little Rock AR 72202
Phone501-364-1418
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    Collapse Overview 
    Collapse overview
    Dr. James is the Director of the Translational Research Institute at the University of Arkansas for Medical Sciences. Her research interest is in translational studies of acetaminophen toxicity. She and her collaborators developed novel approaches for the quantitation of acetaminophen protein adducts in peripheral blood samples. She also directs clinical trials in children to develop safe and effective drug dosing strategies in a number of disease areas.


    Collapse Biography 
    Collapse Leadership and Administrative Roles
    Director, Translational Research Institute

    Collapse credentials

    Collapse Research 
    Collapse research activities and funding
    1UM1TR004909-01     (JAMES, LAURA P)Jul 1, 2024 - Jun 30, 2031
    NIH/National Center for Advancing Translational Sciences
    Expanding Translational Science in Arkansas
    Role: Principal Investigator
    1UM1TR004909-02     (JAMES, LAURA P)Jul 1, 2024 - Jun 30, 2031
    NIH/National Center for Advancing Translational Sciences
    Expanding Translational Science in Arkansas
    Role: Principal Investigator
    1UM1TR004909-03     (JAMES, LAURA P)Jul 1, 2024 - Jun 30, 2031
    NIH/National Center for Advancing Translational Sciences
    Expanding Translational Science in Arkansas
    Role: Principal Investigator
    1UM1TR004909-04     (JAMES, LAURA P)Jul 1, 2024 - Jun 30, 2031
    NIH/National Center for Advancing Translational Sciences
    Expanding Translational Science in Arkansas
    Role: Principal Investigator
    1UM1TR004909-05     (JAMES, LAURA P)Jul 1, 2024 - Jun 30, 2031
    NIH/National Center for Advancing Translational Sciences
    Expanding Translational Science in Arkansas
    Role: Principal Investigator
    1UM1TR004909-06     (JAMES, LAURA P)Jul 1, 2024 - Jun 30, 2031
    NIH/National Center for Advancing Translational Sciences
    Expanding Translational Science in Arkansas
    Role: Principal Investigator
    1UM1TR004909-07     (JAMES, LAURA P)Jul 1, 2024 - Jun 30, 2031
    NIH/National Center for Advancing Translational Sciences
    Expanding Translational Science in Arkansas
    Role: Principal Investigator
    UM1TR004909     (JAMES, LAURA P)Jul 1, 2024 - Jun 30, 2031
    NIH
    Expanding Translational Science in Arkansas
    Role: Principal Investigator
    6922-03-COVID-S016     (MCELFISH, PEARL A)Apr 1, 2024 - Mar 31, 2028
    Westat - Pass Through: Westat
    FOOD AS MEDICINE: ADDRESSING SOCIAL DETERMINANTS OF HEALTH (FOOD INSECURITY) TO EFFECT CLINICAL OUTCOMES (CEAL)
    Role: Principal Investigator
    1U24TR004437     (JAMES, LAURA P)Nov 1, 2023 - Apr 30, 2028
    NIH/National Center for Advancing Translational Sciences - Pass Through: Vanderbilt University
    Engaging Cooperative Sites for Trial Acceleration, Trust, Innovation, and Capability (ECSTATIC)
    Role: Principal Investigator
    1U24TR004437-01     (JAMES, LAURA P)Nov 1, 2023 - Apr 30, 2028
    NIH/National Center for Advancing Translational Sciences - Pass Through: Vanderbilt University
    Engaging Cooperative Sites for Trial Acceleration, Trust, Innovation, and Capability (ECSTATIC)
    Role: Principal Investigator
    VUMC116724     (JAMES, LAURA P)Nov 1, 2023 - Apr 30, 2028
    NIH/National Center for Advancing Translational Sciences - Pass Through: Vanderbilt University
    Engaging Cooperative Sites for Trial Acceleration, Trust, Innovation, and Capability (ECSTATIC)
    Role: Principal Investigator
    SUB-OTA No. 6922-03-COVID-S016     (MCELFISH, PEARL A)Jul 16, 2023 - Mar 31, 2024
    NIH/Nat. Heart, Lung & Blood Institute - Pass Through: Westat
    Community Engagement Research Alliance (CEAL) 2023-2024 Renewal
    Role: Principal Investigator
    2SB1DK079387-09A1     (JAMES, LAURA P)Apr 15, 2022 - Mar 31, 2026
    NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases - Pass Through: Acetaminophen Toxicity Diagnostics, LLC
    AcetaSTAT Validation and Commercialization
    Role: Principal Investigator
    2SB1DK079387-10     (JAMES, LAURA P)Apr 15, 2022 - Mar 31, 2026
    NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases - Pass Through: Acetaminophen Toxicity Diagnostics, LLC
    AcetaSTAT Validation and Commercialization
    Role: Principal Investigator
    6793-02-S016     (JAMES, LAURA P)May 1, 2021 - Mar 31, 2025
    NIH/Nat. Heart, Lung & Blood Institute - Pass Through: Westat
    COVID-19 PREVENT (Partnership for Rapid Engagement to enhance Vaccine uptake for Everyone: Neighbors working Together) Project
    Role: Principal Investigator
    6922-03-COVID S016     (JAMES, LAURA P)May 1, 2021 - Mar 31, 2025
    NIH/Nat. Heart, Lung & Blood Institute - Pass Through: Westat
    COVID-19 PREVENT (Partnership for Rapid Engagement to enhance Vaccine uptake for Everyone: Neighbors working Together) Project
    Role: Principal Investigator
    OT2HL156812     (JAMES, LAURA P)May 1, 2021 - Mar 31, 2025
    NIH/Nat. Heart, Lung & Blood Institute - Pass Through: Westat
    COVID-19 PREVENT (Partnership for Rapid Engagement to enhance Vaccine uptake for Everyone: Neighbors working Together) Project
    Role: Principal Investigator
    6793     (STEWART, MARY K)May 1, 2021 - Jul 15, 2023
    Westat - Pass Through: NIH/Nat. Heart, Lung & Blood Institute
    COVID-19 PREVENT (Partnership for Rapid Engagement to enhance Vaccine uptake for Everyone: Neighbors working Together) Project
    Role: Principal Investigator
    UL1TR003107     (JAMES, LAURA P)Jul 1, 2019 - Jun 30, 2024
    NIH
    Expanding Translational Research in Arkansas
    Role: Principal Investigator
    ABCRP FY19     (EOFF, ROBERT L)Feb 1, 2019 - Jun 30, 2021
    UAMS Executive Breast Committee
    No FP attached
    Role: Principal Investigator
    U54TR001629     (JAMES, LAURA P)Sep 26, 2017 - Aug 31, 2019
    NIH
    Expanding Translational Research in Arkansas
    Role: Principal Investigator
    1UG1HD090876     (JAMES, LAURA P)Oct 1, 2016 - Sep 30, 2020
    NIH
    Arkansas Center for Advancing Pediatric Therapeutics
    Role: Principal Investigator
    UG1OD024945     (JONES, STACIE M)Sep 23, 2016 - Aug 31, 2025
    NIH
    Arkansas ECHO ISPCTN Site (AREIS)
    Role: Co-Principal Investigator
    ACRI # 034991     (JAMES, LAURA P)Sep 21, 2016 - Aug 31, 2020
    UAMS ACHRI Flow Through
    No FP attached
    Role: Principal Investigator
    ACRI #034991     (JAMES, LAURA P)Sep 21, 2016 - Aug 31, 2020
    UAMS ACHRI Flow Through
    No FP attached
    Role: Principal Investigator
    UG1HD090876     (KEARNS, GREGORY LEE)Sep 21, 2016 - Sep 22, 2016
    NIH
    Arkansas Center for Advancing Pediatric Therapeutics (ArCAPT)
    Role: Co-Principal Investigator
    R01-DA039143     Sep 1, 2016 - Aug 30, 2021
    NIH
    Synthetic Cannabinoid Toxicity: Role of Biotransformation
    Role: Co-Investigator
    ACRI # 038461     (JAMES, LAURA P)Aug 11, 2016 - Dec 31, 2026
    UAMS ACHRI Flow Through
    No FP attached
    Role: Principal Investigator
    R01DA039143     (PRATHER, PAUL L)May 15, 2016 - Apr 30, 2021
    NIH
    Synthetic Cannabinoid Toxicity: Role of Biotransformation
    Role: Co-Investigator
    ACRI #034966     (JAMES, LAURA P)Apr 1, 2016 - Mar 31, 2020
    UAMS ACHRI Flow Through
    No FP attached
    Role: Principal Investigator
    2R42DK079387     (JAMES, LAURA P)Apr 1, 2016 - Mar 3, 2019
    NIH/NIDDK
    Adduct Dipstick for Diagnosis of Acetaminophen Toxicity
    Role: Principal Investigator
    UL1RR029884     (JAMES, LAURA P)Jul 14, 2009 - Mar 31, 2016
    NIH/National Center for Advancing Translational Sciences
    Arkansas Center for Clinical & Translational Research
    Role: Principal Investigator
    UL1RR029884     (JAMES, LAURA P)Jul 14, 2009 - Mar 31, 2016
    NIH/National Center for Advancing Translational Sciences
    Arkansas Center for Clinical & Translational Research
    Role: Principal Investigator
    KL2TR000063     (JAMES, LAURA P)Jul 14, 2009 - Mar 31, 2016
    NIH
    Arkansas Center for Clinical Translational Research
    Role: Co-Principal Investigator
    UL1TR000039     (JAMES, LAURA P)Jul 14, 2009 - Mar 31, 2016
    NIH
    Arkansas Center for Clinical and Translational Research
    Role: Co-Principal Investigator
    R01DK081406     (JAMES, LAURA P)Jun 15, 2009 - Mar 31, 2015
    NIH
    Identification of new mechanistic biomarkers of adverse responses to acetaminophe
    Role: Principal Investigator
    SB1DK079387     (JAMES, LAURA P)Apr 1, 2008 - Mar 31, 2025
    NIH
    AcetaSTAT Validation and Commercialization
    Role: Principal Investigator
    R41DK079387     (JAMES, LAURA P)Apr 1, 2008 - Mar 31, 2011
    NIH
    Dipstick Assay for Detection of Acetaminophen Protein Adducts
    Role: Principal Investigator
    R01DK075936     (JAMES, LAURA P)Aug 24, 2007 - May 31, 2014
    NIH
    HIF-1alpha and VEGF in Acetaminophen Toxicity and Repair
    Role: Principal Investigator
    R42DK079387     (JAMES, LAURA PHILLIPS)Jul 1, 2007 - Mar 31, 2021
    NIH
    AcetaSTAT Rapid Assay for Acetaminophen Liver Injury
    Role: Principal Investigator
    R03DK067999     (JAMES, LAURA P)Sep 1, 2004 - Aug 31, 2007
    NIH
    Evaluation of a Biomarker for Acetaminophen Toxicity
    Role: Principal Investigator
    K08DK002971     (JAMES, LAURA P)Feb 15, 2001 - Nov 30, 2005
    NIH
    NOVEL THERAPIES FOR ACETAMINOPHEN TOXICITY
    Role: Principal Investigator
    U10HD031324     (JAMES, LAURA P)Mar 21, 1994 - Dec 31, 2010
    NIH
    Pediatric Pharmacology Research Unit Network
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Rule JA, Ajayi F, James LP, Tujios SR, Sussman NL, Rakela JL, Ganger D, Bass NL, Reuben A, Stravitz RT, Lee WM. Differentiating Ischemic Hepatitis from Acetaminophen Overdose in Acute Liver Failure: Role of Acetaminophen Adducts-Ischemic Hepatitis vs Acetaminophen Overdose. Dig Dis Sci. 2024 Sep 02. PMID: 39222204.
      View in: PubMed
    2. Li C, Malapati SJ, James LP, Hutchins LF. Racial Disparity in Adherence to Endocrine Therapy among Women with Early-Stage Hormone Receptor Positive Breast Cancer: An Analysis of Arkansas All-Payers Claims Database. Clin Breast Cancer. 2024 Oct; 24(7):647-659.e4. PMID: 39153933.
      View in: PubMed
    3. Lee WM, Barnard C, Rule JA, Orandi BJ, James LP, Stravitz RT, Durkalski V, Fontana RJ. Association of Acetaminophen (Paracetamol) Use With Severity and Outcomes in Patients With Viral Hepatitis-Associated Acute Liver Failure. Am J Gastroenterol. 2024 Jul 12. PMID: 38994834.
      View in: PubMed
    4. Thompson EJ, Jeong A, Helfer VE, Shakhnovich V, Edginton A, Balevic SJ, James LP, Collier DN, Anand R, Gonzalez D. Physiologically-based pharmacokinetic modeling of pantoprazole to evaluate the role of CYP2C19 genetic variation and obesity in the pediatric population. CPT Pharmacometrics Syst Pharmacol. 2024 Aug; 13(8):1394-1408. PMID: 38837864.
      View in: PubMed
    5. James LP, Kimberly R, Lindsell CJ, Meinzen-Derr JK, O'Hara R. Scientia pro bono humani generis: Science for the benefit of humanity. J Clin Transl Sci. 2024; 8(1):e29. PMID: 38384907.
      View in: PubMed
    6. Bradley JS, Goldman JL, James LP, Kaelin B, Gibson BHY, Arrieta A. Pharmacokinetics and safety of a single dose of telavancin in pediatric subjects 2-17 years of age. Antimicrob Agents Chemother. 2023 11 15; 67(11):e0098723. PMID: 37815398.
      View in: PubMed
    7. Yiew NKH, Vazquez JH, Martino MR, Kennon-McGill S, Price JR, Allard FD, Yee EU, Layman AJ, James LP, McCommis KS, Finck BN, McGill MR. Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult. Mol Metab. 2023 Nov; 77:101808. PMID: 37716594.
      View in: PubMed
    8. Avram M, Bodinger CA, Clark MA, Stuckey DG, Mathews SE, Stogsdill SN, Barna EC, Williams DK, McGill M, Fantegrossi WE, Liebelt EL, James LP, Endres GW, Moran JH. Hands-Free Analytical Urine Testing Technology Validated for Drug-Facilitated Crime Investigations. Chem Res Toxicol. 2023 Sep 13. PMID: 37703190.
      View in: PubMed
    9. Allen JL, Amick BC, Williams ML, Kennedy JL, Boehme KW, Forrest JC, Primack B, Sides EA, Nembhard WN, Gardner SF, Snowden JN, James LP, Olgaard E, Gandy J. A longitudinal study of SARS-CoV-2 antibody seroprevalence and mitigation behaviors among college students at an Arkansas University. J Am Coll Health. 2023 Jun 08; 1-10. PMID: 37289962.
      View in: PubMed
    10. James L, Venable T, Caro A, Moran JH, Nesmith C, Gannon MA, Cornett LE. Development of a clinical and translational research curriculum for undergraduate students. J Clin Transl Sci. 2023; 7(1):e118. PMID: 37313383.
      View in: PubMed
    11. McElfish PA, Liston R, Smith V, Norris AK, Weaver J, Dickson SM, Macechko MD, Brimberry RK, Lemdja MR, Middleton TL, Nix MW, Irish-Clardy KA, Meredith-Neve SM, Kennedy JL, James LP. Rural Research Network to engage rural and minority community members in translational research. J Clin Transl Res. 2023 Apr 28; 9(2):115-122. PMID: 37179792.
      View in: PubMed
    12. Bona JP, Utecht J, Kemp AS, Gan JM, Caballero A, Trudeau CR, Brochhausen M, James L. The informed consent form navigator: a tool for producing readable and compliant consent documents. J Clin Transl Sci. 2023; 7(1):e3. PMID: 36755541.
      View in: PubMed
    13. James L, O'Sullivan BP, Majure M, Lang J, Ounpraseuth S, Hornik C, Baldner J, Garza M, Prior F, Lee JY, Snowden J. Protocol for the Vitamin D Oral Replacement in Asthma (VDORA) study. Contemp Clin Trials. 2022 09; 120:106861. PMID: 35907490.
      View in: PubMed
    14. Boehme KW, Kennedy JL, Snowden J, Owens SM, Kouassi M, Mann RL, Paredes A, Putt C, James L, Jin J, Du R, Kirkpatrick C, Modi Z, Caid K, Young S, Zohoori N, Kothari A, Boyanton BL, Craig Forrest J. Pediatric SARS-CoV-2 Seroprevalence in Arkansas Over the First Year of the COVID-19 Pandemic. J Pediatric Infect Dis Soc. 2022 Jun 22; 11(6):248-256. PMID: 35294550.
      View in: PubMed
    15. Lang JE, Hornik CP, Elliott C, Silverstein A, Hornik C, Al-Uzri A, Bosheva M, Bradley JS, Borja-Tabora CFC, Di John D, Mendez Echevarria A, Ericson JE, Friedel D, Gonczi F, Isidro MGD, James LP, Kalocsai K, Koutroulis I, Laki I, Ong-Lim ALT, Nad M, Simon G, Syed S, Szabo E, Benjamin DK, Cohen-Wolkowiez M. Solithromycin in Children and Adolescents With Community-acquired Bacterial Pneumonia. Pediatr Infect Dis J. 2022 07 01; 41(7):556-562. PMID: 35675525.
      View in: PubMed
    16. Cardenas VM, Kennedy JL, Williams M, Nembhard WN, Zohoori N, Du R, Jin J, Boothe D, Fischbach LA, Kirkpatrick C, Modi Z, Caid K, Owens S, Forrest JC, James L, Boehme KW, Olgaard E, Gardner SF, Amick BC. State-wide random seroprevalence survey of SARS-CoV-2 past infection in a southern US State, 2020. PLoS One. 2022; 17(4):e0267322. PMID: 35476717.
      View in: PubMed
    17. Holloway JM, Klein T, Wiersma-Mosley JD, Jozkowski KN, Terrell A, James L. Experiences of sexual assault and rape among college students with disabilities. J Am Coll Health. 2024 Apr; 72(3):761-767. PMID: 35380930.
      View in: PubMed
    18. Kennedy JL, Forrest JC, Young SG, Amick B, Williams M, James L, Snowden J, Cardenas VM, Boothe D, Kirkpatrick C, Modi Z, Caid K, Owens S, Kouassi M, Mann R, Putt C, Irish-Clardy K, Macechko M, Brimberry RK, Nembhard WN, McElfish PA, Du R, Jin J, Zohoori N, Kothari A, Hagrass H, Olgaard E, Boehme KW. Temporal Variations in Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus 2 Infections by Race and Ethnicity in Arkansas. Open Forum Infect Dis. 2022 May; 9(5):ofac154. PMID: 35493126.
      View in: PubMed
    19. Steele RW, Moran JH, Patton AL, Kokes CP, James LP, Storm EA, Schexnayder SM. The Spice of Death: Sudden Cardiac Arrest After Novel Psychoactive Substance Exposure. Pediatr Emerg Care. 2022 Jan 01; 38(1):e63-e64. PMID: 34534160.
      View in: PubMed
    20. Clemens MM, Kennon-McGill S, Vazquez JH, Stephens OW, Peterson EA, Johann DJ, Allard FD, Yee EU, McCullough SS, James LP, Finck BN, McGill MR. Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk. Acta Pharm Sin B. 2021 Dec; 11(12):3836-3846. PMID: 35024310.
      View in: PubMed
    21. McGill MR, James LP, McCullough SS, Moran JH, Mathews SE, Peterson EC, Fleming DP, Tripod ME, Vazquez JH, Kennon-McGill S, Spencer HJ, Dranoff JA. Short-Term Safety of Repeated Acetaminophen Use in Patients With Compensated Cirrhosis. Hepatol Commun. 2022 02; 6(2):361-373. PMID: 34558847.
      View in: PubMed
    22. Fountain S, Hale R, Spencer N, Morgan J, James L, Stewart MK. A 10-Year Systematic Review of Photovoice Projects With Youth in the United States. Health Promot Pract. 2021 11; 22(6):767-777. PMID: 34269073.
      View in: PubMed
    23. McElfish PA, Purvis R, James LP, Willis DE, Andersen JA. Perceived Barriers to COVID-19 Testing. Int J Environ Res Public Health. 2021 02 25; 18(5). PMID: 33668958.
      View in: PubMed
    24. Boateng BA, Oliveto AH, Bailey M, Hunter-Lewis M, Young J, James LP. Utility of Protocol Development Software for IRB Protocol Development: Experiences from one Institution. SOCRA Source. 2021 Feb; 107:39-42. PMID: 34646090.
      View in: PubMed
    25. Moran JH, Kessler L, Moylan J, Forrest C, Boehme K, Kennedy J, Greninger A, Baird G, Olgaard E, James L. Modifying laboratory testing via home brew during the COVID-19 pandemic. J Clin Transl Sci. 2021 Jan 25; 5(1):e93. PMID: 34192050.
      View in: PubMed
    26. McElfish PA, Willis DE, Bryant-Moore K, Rojo MO, Andersen JA, Kaminicki KF, James LP. Arkansans' Preferred COVID-19 Testing Locations. J Prim Care Community Health. 2021 Jan-Dec; 12:21501327211004289. PMID: 33771056.
      View in: PubMed
    27. Purvis RS, Long CR, James LP, Kimminau K, Riklon S, Carleton A, Netwon M, Clarence K, Iban A, Mejbon R, Lakmis R, McElfish PA. Dissemination Protocol for Community-Based Participatory Research Partnerships with Marshallese Pacific Islanders in Arkansas. Prog Community Health Partnersh. 2021; 15(3):369-383. PMID: 37934424.
      View in: PubMed
    28. Jenjaroenpun P, Wanchai V, Ono-Moore KD, Laudadio J, James LP, Adams SH, Prior F, Nookaew I, Ussery DW, Wongsurawat T. Two SARS-CoV-2 Genome Sequences of Isolates from Rural U.S. Patients Harboring the D614G Mutation, Obtained Using Nanopore Sequencing. Microbiol Resour Announc. 2020 Dec 17; 10(1). PMID: 33334896.
      View in: PubMed
    29. McElfish PA, Cleek AB, Willis DE, Purvis RS, James LP. Leveraging community engagement capacity to address COVID-19 disparities among Pacific Islander and Latinx Communities in Arkansas. J Clin Transl Sci. 2020 Dec 07; 5(1):e81. PMID: 34192048.
      View in: PubMed
    30. Clemens MM, Vazquez JH, Kennon-McGill S, McCullough SS, James LP, McGill MR. Pre-treatment twice with liposomal clodronate protects against acetaminophen hepatotoxicity through a pre-conditioning effect. Liver Res. 2020 Sep; 4(3):145-152. PMID: 33042596.
      View in: PubMed
    31. You D, Lyn-Cook LE, Gatti DM, Bell N, Mayeux PR, James LP, Mattes WB, Larson GJ, Harrill AH. Nitrosative Stress and Lipid Homeostasis as a Mechanism for Zileuton Hepatotoxicity and Resistance in Genetically Sensitive Mice. Toxicol Sci. 2020 06 01; 175(2):220-235. PMID: 32170957.
      View in: PubMed
    32. James LP, McGill MR, Roberts DW, Hinson JA, Lee WM. Advances in biomarker development in acetaminophen toxicity. Adv Clin Chem. 2020; 98:35-50. PMID: 32564787.
      View in: PubMed
    33. Mullins ME, James LP. Acute Liver Failure of unclear cause? Acetaminophen-protein adducts make the diagnosis. Toxicol Commun. 2020; 4(1):9-11. PMID: 33778331.
      View in: PubMed
    34. McCullough S, Dweep H, McGill MR, Bhattacharyya S, James L, Frankowski S, Woodall A, Kearns G, Gill P. Granzyme B and miR-378a Interaction in Acetaminophen Toxicity in Children. Microrna. 2020; 9(2):121-132. PMID: 31393259.
      View in: PubMed
    35. Jiang S, Madrasi K, Samant T, Lagishetty C, Vozmediano V, Chiew A, Abdel-Rahman SM, James LP, Schmidt S. Population Pharmacokinetic Modeling of Acetaminophen Protein Adducts in Adults and Children. J Clin Pharmacol. 2020 May; 60(5):595-604. PMID: 31802503.
      View in: PubMed
    36. Chiew AL, James LP, Isbister GK, Pickering JW, McArdle K, Chan BSH, Buckley NA. Early acetaminophen-protein adducts predict hepatotoxicity following overdose (ATOM-5). J Hepatol. 2020 03; 72(3):450-462. PMID: 31760072.
      View in: PubMed
    37. McElfish PA, Long CR, James LP, Scott AJ, Flood-Grady E, Kimminau KS, Rhyne RL, Burge MR, Purvis RS. Characterizing health researcher barriers to sharing results with study participants. J Clin Transl Sci. 2019 Dec; 3(6):295-301. PMID: 31827902.
      View in: PubMed
    38. Stewart MK, Boateng B, Joosten Y, Burshell D, Broughton H, Calhoun K, Huff Davis A, Hale R, Spencer N, Piechowski P, James L. Community advisory boards: Experiences and common practices of clinical and translational science award programs. J Clin Transl Sci. 2019 Oct; 3(5):218-226. PMID: 31660246.
      View in: PubMed
    39. Ewing LE, McGill MR, Yee EU, Quick CM, Skinner CM, Kennon-McGill S, Clemens M, Vazquez JH, McCullough SS, Williams DK, Kutanzi KR, Walker LA, ElSohly MA, James LP, Gurley BJ, Koturbash I. Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration. Molecules. 2019 Jun 17; 24(12). PMID: 31212965.
      View in: PubMed
    40. Jiang S, Vozmediano V, Abdel-Rahman SM, Schmidt S, James LP. Acetaminophen Protein Adducts in Hospitalized Children Receiving Multiple Doses of Acetaminophen. J Clin Pharmacol. 2019 10; 59(10):1291-1299. PMID: 31099052.
      View in: PubMed
    41. Long CR, Purvis RS, Flood-Grady E, Kimminau KS, Rhyne RL, Burge MR, Stewart MK, Jenkins AJ, James LP, McElfish PA. Health researchers' experiences, perceptions and barriers related to sharing study results with participants. Health Res Policy Syst. 2019 Mar 04; 17(1):25. PMID: 30832733.
      View in: PubMed
    42. Boateng BA, Indelicato N, Fischer EP, Delgado PL, Aitken ME, James LP. Beyond the common metrics: Expanding the impact of the KL2 mentored career development program using alternative impact assessment frameworks. J Clin Transl Sci. 2019 Feb; 3(1):1-4. PMID: 31404156.
      View in: PubMed
    43. Kennedy JL, Kurten RC, McCullough S, Panettieri RA, Koziol-White C, Jones SM, Caid K, Gill PS, Roberts D, Jaeschke H, McGill MR, James L. Acetaminophen is both bronchodilatory and bronchoprotective in human precision cut lung slice airways. Xenobiotica. 2019 Sep; 49(9):1106-1115. PMID: 30328361.
      View in: PubMed
    44. Stass H, Lettieri J, Vanevski KM, Willmann S, James LP, Sullivan JE, Arrieta AC, Bradley JS. Pharmacokinetics, Safety, and Tolerability of Single-Dose Intravenous Moxifloxacin in Pediatric Patients: Dose Optimization in a Phase 1 Study. J Clin Pharmacol. 2019 05; 59(5):654-667. PMID: 30681729.
      View in: PubMed
    45. Clemens MM, Kennon-McGill S, Apte U, James LP, Finck BN, McGill MR. The inhibitor of glycerol 3-phosphate acyltransferase FSG67 blunts liver regeneration after acetaminophen overdose by altering GSK3? and Wnt/?-catenin signaling. Food Chem Toxicol. 2019 Mar; 125:279-288. PMID: 30654094.
      View in: PubMed
    46. Shakhnovich V, Brian Smith P, Guptill JT, James LP, Collier DN, Wu H, Livingston CE, Zhao J, Kearns GL, Cohen-Wolkowiez M. A Population-Based Pharmacokinetic Model Approach to Pantoprazole Dosing for Obese Children and Adolescents. Paediatr Drugs. 2018 Oct; 20(5):483-495. PMID: 30097906.
      View in: PubMed
    47. Hutchison RD, Ford BM, Franks LN, Wilson CD, Yarbrough AL, Fujiwara R, Su MK, Fernandez D, James LP, Moran JH, Patton AL, Fantegrossi WE, Radominska-Pandya A, Prather PL. Atypical Pharmacodynamic Properties and Metabolic Profile of the Abused Synthetic Cannabinoid AB-PINACA: Potential Contribution to Pronounced Adverse Effects Relative to ?9-THC. Front Pharmacol. 2018; 9:1084. PMID: 30319418.
      View in: PubMed
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    54. Shakhnovich V, Smith PB, Guptill JT, James LP, Collier DN, Wu H, Livingston CE, Zhao J, Kearns GL. Obese Children Require Lower Doses of Pantoprazole Than Nonobese Peers to Achieve Equal Systemic Drug Exposures. J Pediatr. 2018 02; 193:102-108.e1. PMID: 29389444.
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    57. Hadden KB, Prince L, James L, Holland J, Trudeau CR. Readability of Human Subjects Training Materials for Research. J Empir Res Hum Res Ethics. 2018 02; 13(1):95-100. PMID: 29243548.
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    62. Gonzalez D, Bradley JS, Blumer J, Yogev R, Watt KM, James LP, Palazzi DL, Bhatt-Mehta V, Sullivan JE, Zhang L, Murphy J, Ussery XT, Puttagunta S, Dunne MW, Cohen-Wolkowiez M. Dalbavancin Pharmacokinetics and Safety in Children 3 Months to 11 Years of Age. Pediatr Infect Dis J. 2017 07; 36(7):645-653. PMID: 28060045.
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    64. Banerjee S, Melnyk SB, Krager KJ, Aykin-Burns N, McCullough SS, James LP, Hinson JA. Trifluoperazine inhibits acetaminophen-induced hepatotoxicity and hepatic reactive nitrogen formation in mice and in freshly isolated hepatocytes. Toxicol Rep. 2017; 4:134-142. PMID: 28503408.
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    65. Roberts DW, Lee WM, Hinson JA, Bai S, Swearingen CJ, Stravitz RT, Reuben A, Letzig L, Simpson PM, Rule J, Fontana RJ, Ganger D, Reddy KR, Liou I, Fix O, James LP. An Immunoassay to Rapidly Measure Acetaminophen Protein?Adducts Accurately Identifies Patients With Acute Liver?Injury or Failure. Clin Gastroenterol Hepatol. 2017 Apr; 15(4):555-562.e3. PMID: 27641661.
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    67. Dobson NR, Liu X, Rhein LM, Darnall RA, Corwin MJ, McEntire BL, Ward RM, James LP, Sherwin CM, Heeren TC, Hunt CE. Salivary caffeine concentrations are comparable to plasma concentrations in preterm infants receiving extended caffeine therapy. Br J Clin Pharmacol. 2016 09; 82(3):754-61. PMID: 27145974.
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    71. Redwine KM, James LP, O'Riordan M, Sullivan JE, Blumer JL. Accuracy of the Spacelabs 90217 ambulatory blood pressure monitor in a pediatric population. Blood Press Monit. 2015 Oct; 20(5):295-8. PMID: 26529437.
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    74. Guldiken N, Zhou Q, Kucukoglu O, Rehm M, Levada K, Gross A, Kwan R, James LP, Trautwein C, Omary MB, Strnad P. Human keratin 8 variants promote mouse acetaminophen hepatotoxicity coupled with c-jun amino-terminal kinase activation and protein adduct formation. Hepatology. 2015 Sep; 62(3):876-86. PMID: 25963979.
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    89. Levi MS, Patton RE, Hanig JP, Tranter KM, George NI, James LP, Davis KJ, Bowyer JF. Serum myoglobin, but not lipopolysaccharides, is predictive of AMPH-induced striatal neurotoxicity. Neurotoxicology. 2013 Jul; 37:40-50. PMID: 23608161.
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    90. Abdel-Rahman SM, Paul IM, James LP, Lewandowski A. Evaluation of the Mercy TAPE: performance against the standard for pediatric weight estimation. Ann Emerg Med. 2013 Oct; 62(4):332-339.e6. PMID: 23602655.
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    105. Bhutta AT, Schmitz ML, Swearingen C, James LP, Wardbegnoche WL, Lindquist DM, Glasier CM, Tuzcu V, Prodhan P, Dyamenahalli U, Imamura M, Jaquiss RD, Anand KJ. Ketamine as a neuroprotective and anti-inflammatory agent in children undergoing surgery on cardiopulmonary bypass: a pilot randomized, double-blind, placebo-controlled trial. Pediatr Crit Care Med. 2012 May; 13(3):328-37. PMID: 21926656.
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    106. Mian A, Becton D, Saylors R, James L, Tang X, Bhutta A, Prodhan P. Biomarkers for risk stratification of febrile neutropenia among children with malignancy: a pilot study. Pediatr Blood Cancer. 2012 Aug; 59(2):238-45. PMID: 22535591.
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    107. Farrar HC, Grayham T, Bolden B, Vyas D, Graham J, James LP. The use and tolerability of Crotalidae Polyvalent Immune FAB (Ovine) in pediatric envenomations. Clin Pediatr (Phila). 2012 Oct; 51(10):945-9. PMID: 22511193.
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    108. Kelkar M, Cleves MA, Foster HR, Hogan WR, James LP, Martin BC. Acute and chronic acetaminophen use and renal disease: a case-control study using pharmacy and medical claims. J Manag Care Pharm. 2012 Apr; 18(3):234-46. PMID: 22468732.
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    111. Fukuda T, Goebel J, Cox S, Maseck D, Zhang K, Sherbotie JR, Ellis En, James LP, Ward RM, Vinks AA. UGT1A9, UGTB7, and MRP2 genotypes can predict mycophenolic acid pharmacokinetic variability in pediatric kidney transplant recipients. Ther Drug Monit. 2012; 34(6):671-79.
    112. Paine M, Chimalakonda KC, Seely KA, Bratton SM, Brents LK, Moran CL, Endres GW, James LP, Hollenberg PF, Prather PL, Radominska-Pandya A, Moran JH. P450-mediated oxidative metabolism of abused synthetic cannabinoids found in “K2/Spice”: identification of novel cannabinoid receptor ligands. Drug Metab Dispos. 2012; 40(11):2174-84.
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    114. Milesi-Hall? A, McCullough S, Hinson JA, Kurten RC, Lamps LW, Brown A, James LP. Echinomycin decreases induction of vascular endothelial growth factor and hepatocyte regeneration in acetaminophen toxicity in mice. Basic Clin Pharmacol Toxicol. 2012 Apr; 110(4):327-34. PMID: 21985601.
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    115. Brown AT, Ou X, James LP, Jambhekar K, Pandey T, McCullough S, Chaudhuri S, Borrelli MJ. Correlation of MRI findings to histology of acetaminophen toxicity in the mouse. Magn Reson Imaging. 2012 Feb; 30(2):283-9. PMID: 22055850.
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    119. Chimalakonda KC, Bratton SM, Le VH, Yiew KH, Dineva A, Moran CL, James LP, Moran JH, Radominska-Pandya A. Conjugation of synthetic cannabinoids JWH-018 and JWH-073, metabolites by human UDP-glucuronosyltransferases. Drug Metab Dispos. 2011 Oct; 39(10):1967-76. PMID: 21746969.
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    121. Ceelie I, James LP, Gijsen V, Mathot RA, Ito S, Tesselaar CD, Tibboel D, Koren G, de Wildt SN. Acute liver failure after recommended doses of acetaminophen in patients with myopathies. Crit Care Med. 2011 Apr; 39(4):678-82. PMID: 21242792.
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    122. Heard KJ, Green JL, James LP, Judge BS, Zolot L, Rhyee S, Dart RC. Acetaminophen-cysteine adducts during therapeutic dosing and following overdose. BMC Gastroenterol. 2011 Mar 14; 11:20. PMID: 21401949.
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    123. Hubbard JJ, James LP. Complications and outcomes of brown recluse spider bites in children. Clin Pediatr (Phila). 2011 Mar; 50(3):252-8. PMID: 21307081.
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    124. Farst K, Reading Meyer JA, Mac Bird T, James L, Robbins JM. Hair drug testing of children suspected of exposure to the manufacture of methamphetamine. J Forensic Leg Med. 2011 Apr; 18(3):110-4. PMID: 21420647.
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    126. Seely KA, Prather PL, James LP, Moran JH. Marijuana-based drugs: innovative therapeutics or designer drugs of abuse? Mol Interv. 2011 Feb; 11(1):36-51. PMID: 21441120.
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    127. Khandelwal N, James LP, Sanders C, Larson AM, Lee WM. Unrecognized acetaminophen toxicity as a cause of indeterminate acute liver failure. Hepatology. 2011 Feb; 53(2):567-76. PMID: 21274877.
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    128. Milesi-Halle A, Abdel-Rahman SM, Brown A, McCullough SS, Letzig L, Hinson JA, James LP. Indocyanin green clearance varies as a function of n-acetylcysteine treatment in a murine model of acetaminophen toxicity. Chemico Biol Interact. 2011; 189(222-229).
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    131. Radominska-Pandya A, Chimalakonda K, Bratton SM, Vi-Huyen L, Yiew K, James LP, Moran JH. Conjugation of JWH-018 and JWH-073 metabolites by human UDP-glucuronosyltransferases. Drug Metab Dispos. 2011; 39(10):1967-76.
    132. Moran CL, Le VH, Chimalakonda KC, Smedley AL, Lackey FD, Owen SN, Kennedy PD, Endres GW, Ciske FL, Kramer JB, Kornilov AM, Bratton LD, Dobrowolski PH, Wessinger WD, Fantegrossi WE, Prather PP, James LP, Radominski-Pandya A, Moran JH. Quantitative measurement of JWH-018 and JWH-073 metabolites excreted in human urine and identification of specific biomarkers. Analytical Chemistry. 2011; 83(11):4228-36.
    133. Seely KA, Prather PL, James LP, Moran JH. marijuana-based drugs: Innovateive therapeutics or designer drugs of abuse. Molecular Interventions. 2011; 11(1):36-51.
    134. Radominska-Pandya A, Bratton SM, Chib S, Blevins JM, Gallus-Zawada A, Moran C, James LP, Moran JH. Oxidation of abused synthetic cannabinoids in K2/Spice by human cytochromes P450. Experimental Biology. 2011.
    135. James LP, Roberts DW, Sullivan JE. A proper use of acetaminophen. Paediatr Child Health. 2011; 16(9):544-47.
    136. Ward RM, Kearns GL, Tammara B, Bishop P, O'Gorman MA, James LP, Katz MH, Maguire MK, Rath N, Meng X, Comer GM. A multicenter, randomized, open-label, pharmacokinetics and safety study of Pantoprazole tablets in children and adolescents aged 6 through 16 years with GERD. J Clin Pharm. 2011; 5(6):876-87.
    137. Lapoint J, Moran CL, Nelson LS, Hoffman RS, Moran JH. Severe toxicity following synthetic cannabinoid ingestion. Clin Tox (Phila). 2011; 49(8):760-4.
    138. T Grayham, James L, F Henry, D Vyas, J Graham. The tolerability of crotalidae polyvalent immune fab in pediatric snakebite. SSPR. 2011.
    139. Lapoint J, James LP, Moran C, Nelson L, Hoffman RS, Moran J. Severe toxicity following synthetic cannabinoid ingestion. Clin Tox. 2011; 49(8):760-4.
    140. Redwine K, Howard L, Simspon P, Li SH, James L, Blumer J, Sullivan J, Ward R, Wells T. Effects of placebo on ambulatory blood pressure monitoring in children. Pediatric Academic Societies and Asian Society for Pediatric Research. 2011.
    141. Ajmera V, Xia G, Vaughan G, Forbi J, Ganova-Raeva LM, Khudyakov Y, Opio CK, Taylor R, Restrepo R, Munoz S, Fontana RJ, James LP, Lee WM, And the Acute Liver Failure Study Group. What factors determine the severity of Hepatitis A related acute liver failure?. J Viral Hepat. 2011; 1(252):211-20.
    142. Agarwal R, MacMillan-Crow LA, Rafferty TM, Saba H, Roberts DW, Fifer EK, James LP, Hinson JA. Acetaminophen-induced hepatotoxicity in mice occurs with inhibition of activity and nitration of mitochondrial manganese superoxide dismutase. J Pharmacol Exp Ther. 2011 Apr; 337(1):110-6. PMID: 21205919.
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    143. Milesi-Hall? A, Abdel-Rahman SM, Brown A, McCullough SS, Letzig L, Hinson JA, James LP. Indocyanine green clearance varies as a function of N-acetylcysteine treatment in a murine model of acetaminophen toxicity. Chem Biol Interact. 2011 Feb 01; 189(3):222-9. PMID: 21145883.
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    144. Ward RM, Kearns GL, Tammara B, Bishop P, O'Gorman MA, James LP, Katz MH, Maguire MK, Rath N, Meng X, Comer GM. A multicenter, randomized, open-label, pharmacokinetics and safety study of pantoprazole tablets in children and adolescents aged 6 through 16 years with gastroesophageal reflux disease. J Clin Pharmacol. 2011 Jun; 51(6):876-87. PMID: 20852004.
      View in: PubMed
    145. Donahower BC, McCullough SS, Hennings L, Simpson PM, Stowe CD, Saad AG, Kurten RC, Hinson JA, James LP. Human recombinant vascular endothelial growth factor reduces necrosis and enhances hepatocyte regeneration in a mouse model of acetaminophen toxicity. J Pharmacol Exp Ther. 2010 Jul; 334(1):33-43. PMID: 20363854.
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    146. Hinson JA, Roberts DW, James LP. Mechanisms of acetaminophen-induced liver necrosis. Handb Exp Pharmacol. 2010; (196):369-405. PMID: 20020268.
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    147. Hubbard J, James LP. Brown Recluse Spider Bite Effects and Outcomes in Children in Arkansas. First Annuan MD/PhD Graduate Student Research Symposium. 2010.
    148. Getachew Y, James LP, Lee WM, Thiele DL, Miller BC. Susceptibility to acetaminophen (APAP) toxicity unexpectedly is decreased during acute viral hepatitis in mice. Biochem Pharm. 2010; 79(9):1363-71.
    149. O'Brien C, Lowery J, Palmer K, James L. Neonatal and Pediatric Pharmacology: Therapeutic Principles in Practice. Gastrointestinal Drugs. 2010.
    150. Gardner A, Byrnes J, James LP, Moss M. Suspected trauma in comatose child found to be Baclofen poisoning. The Pediatric Clinical Symposium. 2010.
    151. Donahower BC, McCullough SS, Simpson PM, Lamps L, Stowe CD, Kurten R, Hinson JA, James LP. Examination of exogenous hrVEGF in a mouse model of acetaminophen toxicity. JPET. 2010; 334(1):33-43.
    152. Ortmann LA, Jaeger MW, James LP, Schexnayder SM. Coma in a 20-month-old child from an ingestion of a toy containing 1,4-butanediol, a precursor of gamma-hydroxybutyrate. Pediatr Emerg Care. 2009 Nov; 25(11):758-60. PMID: 19915428.
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    153. Hinson JA, Roberts DW, James LP. Adverse Drug Reactions, Handbook of Experimental Pharmacology. Mechanisms of Acetaminophen-Induced Liver Necrosis. 2009; 12.
    154. James LP, Letzig L, Simpson PM, Capparelli E, Roberts DW, Hinson JA, Davern TJ, Lee WM. Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure. Drug Metab Dispos. 2009 Aug; 37(8):1779-84. PMID: 19439490.
      View in: PubMed
    155. James L, Ito S. Neonatal Pharmacology: rational therapeutics for the most vulnerable. Clin Pharmacol Ther. 2009; 86(6):573-7.
    156. Jones BL, Pearce RE, Abdel-Rahman SM, Friesen CA, James LP, Kearns GL. Characterization of delayed gastric emptying by the 13C-acetate breath test. J Breath Res. 2009; 3(4).
    157. James LP, Capparelli EV, Simpson PM, Letzig L, Roberts D, Hinson JA, Kearns GL, Blumer JL, Sullivan JE. Acetaminophen-associated hepatic injury: evaluation of acetaminophen protein adducts in children and adolescents with acetaminophen overdose. Clin Pharmacol Ther. 2008 Dec; 84(6):684-90. PMID: 18923390.
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    158. O'Brien CE, Harik N, James LP, Seib PM, Stowe CD. Cesium-induced QT-interval prolongation in an adolescent. Pharmacotherapy. 2008 Aug; 28(8):1059-65. PMID: 18657021.
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    159. Kearns GL, Blumer J, Schexnayder S, James LP, Adcock KG, Reed MD, Daniel JF, Gaedigk A, Paul J. Single-dose pharmacokinetics of oral and intravenous pantoprazole in children and adolescents. J Clin Pharmacol. 2008 Nov; 48(11):1356-65. PMID: 18664620.
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    160. O'Brien, Catherine E, Harik, Nada, James LP, Seib, Paul M, Stowe, Cindy D. Cesium-Induced QT-Interval Prolongation in Adolescent. Pharmacotherapy. 2008; 28(8):1059-1065.
    161. Hong H, Teitel C, James LP, Tong W, Hinson JA, Fuscoe JC, Dragan Y. SELDI based proteomic determination of hepatic biomarkers in mourse serum following acetaminophen administration. J of Proteomics and Bioinformatics. 2008; 1(8):424-436.
    162. Ortmann LA, Jaeger MW, Schexnayder SM, James LP. Coma in a 20-month old child from an ingestion of a toy containing 1,4-buanediol, a precursor of gamma-hydroxybutyrate. Pediatric Emergency Care. 2008; 25(11):758-60.
    163. Burke AS, Redeker K, Kurten RC, James LP, Hinson JA. Mechanisms of chloroform-induced hepatotoxicity: oxidative stress and mitochondrial permeability transition in freshly isolated mouse hepatocytes. J Toxicol Environ Health A. 2007 Nov; 70(22):1936-45. PMID: 17966065.
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    164. James L, Walson P, Lomax K, Kao R, Varughese S, Reyes J. Pharmacokinetics and tolerability of rabeprazole sodium in subjects aged 12 to 16 years with gastroesophageal reflux disease: an open-label, single- and multiple-dose study. Clin Ther. 2007 Sep; 29(9):2082-92. PMID: 18035206.
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    165. Vaquero J, Belanger M, James LP, Herrero R, Desjardins P, Cote J, Blei AT, Butterworth RF. Mild hypothermia attenuates liver injury and improves survival in mice with acetaminophen toxicity. Gastroenterology. 2007; 132(1):372-83.
    166. Burke AS, Redeker L, Kurten RC, James LP, HInson JA. Mechanisms of chloroform-induced hepatotoxicity: oxidative stess and mitochondrial permeability transition in freshly isolated mouse hepatocytes. J Toxic & Envirn Hlth. 2007; 70(22):1936-45.
    167. James LP, Walson P, Lomax K, Kao R, Varughese S, James LP. Pharmacokinetics and Tolerability of Rabeprazole in Patients Ages 12 to 16 years with gastroesophageal reflux disease. Clinical Therapeutics. 2007; 29(9):2082-92.
    168. James LP, Alonso EM, Hynan LS, Hinson JA, Davern TJ, Lee WM, Squires RH. Detection of acetaminophen protein adducts in children with acute liver failure of indeterminate cause. Pediatrics. 2006 Sep; 118(3):e676-81. PMID: 16950959.
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    169. Farst K, Duncan JM, Moss M, Ray RM, Kokoska E, James LP. Methamphetamine exposure presenting as caustic ingestions in children. Ann Emerg Med. 2007 Mar; 49(3):341-3. PMID: 17141141.
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    170. Donahower B, McCullough SS, Kurten R, Lamps LW, Simpson P, Hinson JA, James LP. Vascular endothelial growth factor and hepatocyte regeneration in acetaminophen toxicity. Am J Physiol Gastrointest Liver Physiol. 2006 Jul; 291(1):G102-9. PMID: 16565415.
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    171. James LP, Donahower B, Burke AS, McCullough S, Hinson JA. Induction of the nuclear factor HIF-1alpha in acetaminophen toxicity: evidence for oxidative stress. Biochem Biophys Res Commun. 2006 Apr 28; 343(1):171-6. PMID: 16530163.
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    172. Davern TJ, James LP, Hinson JA, Polson J, Larson AM, Fontana RJ, Lalani E, Munoz S, Shakil AO, Lee WM. Measurement of serum acetaminophen-protein adducts in patients with acute liver failure. Gastroenterology. 2006 Mar; 130(3):687-94. PMID: 16530510.
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    173. James LP, Donahower B, Burke AS, McCullough SS, Hinson JA. Induction of the neclear factor HIF-1alpha in livers of acetaminophen treated mice and freshly isolated hepatocytes: evidence for oxidative stress. Biochem and Biophys Resch Comm. 2006; 343:171-176.
    174. James LP, Alonzo E, Hynan LS, Hinson JA, Davern TJ, Lee WM, Squires RH, Pediatrics Acute Liver Failure Study Group. Detection of Acetaminophen Protein Adducts in Children with Acute Liver Failure of Indeterminate Etiology. Pediatrics. 2006; 118(3):e676-e681.
    175. James LP, Simpson PM, Farrar HC, Kearns GL, Wasserman GS, Blumer JL, Reed MD, Sullivan JE, Hinson JA. Cytokines and toxicity in acetaminophen overdose. J Clin Pharmacol. 2005 Oct; 45(10):1165-71. PMID: 16172181.
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    176. James LP, Kurten RC, Lamps LW, McCullough S, Hinson JA. Tumour necrosis factor receptor 1 and hepatocyte regeneration in acetaminophen toxicity: a kinetic study of proliferating cell nuclear antigen and cytokine expression. Basic Clin Pharmacol Toxicol. 2005 Jul; 97(1):8-14. PMID: 15943753.
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    177. Wenning LA, Murphy MG, James LP, Blumer JL, Marshall JD, Baier J, Scheimann AO, Panebianco DL, Zhong L, Eisenhandler R, Yeh KC, Kearns GL. Pharmacokinetics of famotidine in infants. Clin Pharmacokinet. 2005; 44(4):395-406. PMID: 15828852.
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    178. James LP, Kurten RC, Lamps LW, McCullough SS, Hinson JA. Tumor Necrosis Factor Receptor 1 and Hepatocyte Regeneration in Acetaminophen Toxicity: A Kinetic Study of Proliferating Cell Nuclear Antigen and Cytoline Expression. Basic Clin Pharm & Tox. 2005; 97(1):8-14.
    179. Wenning LA, Murphy GM, James LP, Blumer JL, Marshall JD, Baier J, Scheimann AO, Panebianco DL, Zhong L, Eisenhandler R, Yeh KC, Kearns GL. Pharmacokinetics of famotidine in infants less than 1 year of age. Clin Pharm. 2005; 44(3):395-406.
    180. Hinson JA, Reid AB, McCullough SS, James LP. Acetaminophen-induced hepatotoxicity: role of metabolic activation, reactive oxygen/nitrogen species, and mitochondrial permeability transition. Drug Metab Rev. 2004 Oct; 36(3-4):805-22. PMID: 15554248.
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    181. James LP, Simpson PM, Farrar HC, Wasserman G, Kearns GL, Hinson JA. Correlation of MCP1 with toxicity in acetaminophen overdose. J Ark Med Soc. 2004 Jun; 100(12):424-5. PMID: 15200281.
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    182. Palmer KG, James LP. Methemoglobinemia associated with metoclopramide therapy in a neonate. J Pediatr Pharmacol Ther. 2004 Jan; 9(1):49-54. PMID: 23118691.
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    183. James LP, Farrar HC, Palmer K, Kearns GL. Pediatric and Neonatal Pharmacology. Gastrointestinal Drugs. 2004.
    184. Sheffield LJ, Wood JM, James LP, Roche J, Chalkiadis G, Venter JD, Pitt J, Davidson A, Cranswick N. CYP1A2*1F allele predicts risk of liver toxicity in children prescribed acetaminophen following surgery. Presented to The American Society of Human Genetics. 2004.
    185. James LP, McCullough SS, Knight TR, Jaeschke H, Hinson JA. Acetaminophen toxicity in mice lacking NADPH oxidase activity: role of peroxynitrite formation and mitochondrial oxidant stress. Free Radic Res. 2003 Dec; 37(12):1289-97. PMID: 14753753.
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    186. James LP, Mayeux PR, Hinson JA. Acetaminophen-induced hepatotoxicity. Drug Metab Dispos. 2003 Dec; 31(12):1499-506. PMID: 14625346.
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    187. James LP. Efficacy and safety measurements of proton pump inhibitors in infants and children. J Pediatr Gastroenterol Nutr. 2003 Nov-Dec; 37 Suppl 1:S46-51. PMID: 14685078.
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    188. James LP, Lamps LW, McCullough S, Hinson JA. Interleukin 6 and hepatocyte regeneration in acetaminophen toxicity in the mouse. Biochem Biophys Res Commun. 2003 Oct 03; 309(4):857-63. PMID: 13679052.
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    189. Kearns GL, Andersson T, James LP, Gaedigk A, Kraynak RA, Abdel-Rahman SM, Ramabadran K, van den Anker JN. Omeprazole disposition in children following single-dose administration. J Clin Pharmacol. 2003 Aug; 43(8):840-8. PMID: 12953341.
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    190. James LP, McCullough SS, Lamps LW, Hinson JA. Effect of N-acetylcysteine on acetaminophen toxicity in mice: relationship to reactive nitrogen and cytokine formation. Toxicol Sci. 2003 Oct; 75(2):458-67. PMID: 12883092.
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    191. Fahr MJ, James LP, Beck JR, James CA. Digital radiography in the diagnosis of Toddler's fracture. South Med J. 2003 Mar; 96(3):234-9. PMID: 12659353.
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    192. Maples HD, James LP, Stowe CD, Jones DP, Hak EB, Blumer JL, Vogt B, Wilson JT, Kearns GL, Wells TG. Famotidine disposition in children and adolescents with chronic renal insufficiency. J Clin Pharmacol. 2003 Jan; 43(1):7-14. PMID: 12520622.
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    193. Fahr MJ, James LP, Beck JR, James CA. Digital Assessment of Occult Toddler's Fractures. So Med J. 2003; 96(2):1-6.
    194. Maples HD, James LP, Stowe CD, Jones DP, Hak EB, Blumer JL, Vogt B, Wilson JT, Kearns GL, Wells TG, Network of Pediatric Pharmacology Research Units (NICHD). Famotidine Dispostion in Children and Adolscents with Chronic Renal Insufficiency. J Clin Pharm. 2003; 43:7-14.
    195. Kearns GL, Andersson T, James LP, Li BUK, Gaedigk A, Kraynak RA, Ramabadran K, Abdel-Rahman SM, Van den Anker JN. Omeprazole Disposition In Children Following Single-Dose Administration: Relationship to CYP2C19 Genotype. J Clin Pharm. 2003; 43:840-848.
    196. James LP, Wells E, Beard RH, Farrar HC. Predictors of outcome after acetaminophen poisoning in children and adolescents. J Pediatr. 2002 May; 140(5):522-6. PMID: 12032516.
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    197. Muldrew KL, James LP, Coop L, McCullough SS, Hendrickson HP, Hinson JA, Mayeux PR. Determination of acetaminophen-protein adducts in mouse liver and serum and human serum after hepatotoxic doses of acetaminophen using high-performance liquid chromatography with electrochemical detection. Drug Metab Dispos. 2002 Apr; 30(4):446-51. PMID: 11901099.
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    198. James LP. Pharmacology for the gastrointestinal tract. Clin Perinatol. 2002 Mar; 29(1):115-33. PMID: 11917734.
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    199. James LP, Beard R, Wells E, Farrar HC. Predictions of outcome following acetaminophen poisoning in children and adolscents. J Peds. 2002; 140(5):522-526.
    200. Ferron GM, James LP, Kearns GL, Blumer J, Abell M, Mayer PR, Getsy J, Paul J. Pharmacokinetics of oral pantoprazole in pediatric patients. Presented to The American College of Clinical Pharmacy. 2002; 1358.
    201. James LP, Abdel-Rahmen S, Farrar HC, Jacobs RF. Principals and Practice of Pediatric Infectious Disease. Antimicrogial Agents. 2002.
    202. James LP, Simpson P, Farrar H, Casavant M, Van de Anker J, Wasserman G, Kearns G. Elevation of Cytokines in acetaminophen overdose. Presented to The American Academy of Clinical Toxicology. 2002; 599.
    203. James LP. Neonatal Gastroenterology Clinics in Perinatology. Pharmacology for the GI Tract. 2002.
    204. James LP, Farrar HC, Darville TL, Sullivan JE, Givens TG, Kearns GL, Wasserman GS, Simpson PM, Hinson JA. Elevation of serum interleukin 8 levels in acetaminophen overdose in children and adolescents. Clin Pharmacol Ther. 2001 Sep; 70(3):280-6. PMID: 11557916.
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    205. James LP, Farrar HC, Darville TL, Sullivan JE, Givens TG, Kearns GL, Wasserman GS, Simpson PM, HInson JA. Elevation of serum interleukin-8 in acetaminophen overdose in children and adolescents. Clin Pharm Ther. 2001; 70(3):280-286.
    206. James LP, Wilson JT, Simar R, Farrar HC, Kearns GL, Hinson JA, Pumford NR. Evaluation of occult acetaminophen hepatotoxicity in hospitalized children receiving acetaminophen. Clin Ped. 2001; 40(5):243-248.
    207. Kearns GL, Bradley JS, Jacobs RF, Capparelli E, James LP, Johnson KM, Abdel-Rahman SM. Single dose pharmacokinetics of pleconaril in neonates. Ped Inf Dis Jour. 2000; 19:833-839.
    208. Kearns GL, Abdel-Tahman SM, Blumer JL, Reed MD, James LP, Jacobs RF, Weldhman IR, Jungbluth GL, Stalker DJ. Single dose pharmacolkinetics of linezolid in infants and children. Ped Inf Dis Jour. 2000; 19:1178-84.
    209. Kearns GL, Abdel-Rahman SM, James LP, Blowey DL, Marshall JD, Wells TG, Jacobs RF. Single-dose pharmacokinetics of a pleconaril (VP63843) oral solution in children and adolescents. Antimicrobial Agents and Chemotherapy. 1999; 43(3):634-638.
    210. Farrar, HC, James LP. Characteristics of pediatric admissions for cyclic antidepressant poisoning. Am J Emrg Med. 1999; 17(5):495-496.
    211. James LP, Farrar HC, Komoroski EM, Wood WR, Graham CJ, Bornemeier RA, Valentine JL. Sympathormimetic drug use in adolescents presenting to a pediatric emergency department with chrest pain. Clin Tox. 1998; 36(4):321-328.
    212. Schexnayder S, James LP, Kearns GL, Farrar HC. The pharmacokinetics of continuous infusion pralidoxime in children with organophosphate. Clin Tox. 1998; 36(6):459-555.
    213. Nichols MH, King WD, James LP. Clonidine Poisoning in Jefferson County, Alabama. Anul Emerg Med. 1997; 29:511-517.
    214. James LP, King WD. Piercing injury hospitalization in children. Pediatric Emerceny Care. 1996; 12(2):84-86.
    215. James LP, Nichols MH, King WD. Herbs and HIV: the health food industry's answer. Sthn Med Jour. 1995; 88(9):911-913.
    216. Genuardi FJ, King WD, James LP. Outcome of injury-related hospitalizations among youth athletes. Archives of Pediatrics and Adol Med. 1995; 149:1037-1039.
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