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Jeffrey Sawyer

TitleProfessor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPathology, College of Medicine
DivisionPathology Clinical
Address218 Freeway Medical Tower
5800 W. 10th
Mail Slot # 834
Little Rock AR 72204
Phone501-526-8000
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    Other Positions
    TitleProfessor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentGenetics, College of Medicine


    Collapse Research 
    Collapse research activities and funding
    CA81506/03     (SAWYER, JEFFREY R)Feb 23, 2000 - Jan 31, 2005
    NIH/Nat. Cancer Institute
    DNA Hypomethylation and Cancer
    Role: Principal Investigator
    CA81506/02     (SAWYER, JEFFREY R)Feb 23, 2000 - Jan 31, 2002
    NIH/Nat. Cancer Institute
    DNA Hypomethylation and Cancer
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Al Hadidi S, Ababneh OE, Schinke CD, Thanendrarajan S, Bailey C, Smith R, Panozzo S, Alapat D, Cottler-Fox M, Tricot G, Shaughnessy JD, Zhan F, Sawyer J, Barlogie B, Zangari M, van Rhee F. Three years of maintenance with VRD in multiple myeloma: results of total therapy IIIB with a 15-year follow-up. Blood Adv. 2024 02 13; 8(3):703-707. PMID: 38052037.
      View in: PubMed
    2. Farrell ND, Dooley JH, Sheffer BW, Sawyer JR, Kelly DM. Radiation exposure in multiple hereditary exostoses: A retrospective review. J Orthop. 2023 Jun; 40:87-90. PMID: 37234093.
      View in: PubMed
    3. Padgett AM, Kapoor S, Rhodes LN, Keen K, Cao X, Locke LL, Warner WC, Sawyer JR, Sheffer BW, Spence DD, Kelly DM. Perioperative multimodal analgesic injection for patients with adolescent idiopathic scoliosis undergoing posterior spinal fusion surgery. Spine Deform. 2023 07; 11(4):977-984. PMID: 37022606.
      View in: PubMed
    4. Quan T, Matsumoto H, Bonsignore-Opp L, Ramo B, Murphy RF, Brooks JT, Welborn MC, Emans JB, Anari JB, Johnston CE, Akbarnia BA, McCarthy R, Flynn J, Sawyer JR, Vitale MG, Roye BD. Definition of Tweener: Consensus Among Experts in Treating Early-onset Scoliosis. J Pediatr Orthop. 2023 03 01; 43(3):e215-e222. PMID: 36729774.
      View in: PubMed
    5. Patel NM, Schmitz MR, Bastrom TP, Ghag R, Janicki JA, Kushare IV, Lewis R, Mistovich RJ, Nelson SE, Sawyer JR, Vanderhave KL, Wallace MJ, McKay SD. Interobserver and Intraobserver Agreement are Unsatisfactory When Determining Abstract Study Design and Level of Evidence. J Pediatr Orthop. 2022 Jul 01; 42(6):e696-e700. PMID: 35667059.
      View in: PubMed
    6. Mohan M, Kendrick S, Szabo A, Yarlagadda N, Atwal D, Pandey Y, Roy A, Parikh R, Lopez J, Thanendrarajan S, Schinke C, Alapat D, Sawyer J, Tian E, Tricot G, van Rhee F, Zangari M. Clinical implications of loss of bone marrow minimal residual disease negativity in multiple myeloma. Blood Adv. 2022 02 08; 6(3):808-817. PMID: 34807986.
      View in: PubMed
    7. Rambo A, Rhodes L, Lomax J, Cao X, Steele J, Romer K, Spence D, Sheffer BW, Warner WC, Sawyer JR, Kelly DM. Factors that Influence Acquisition of Lower Extremity Braces in the Pediatric Orthopaedic Population. J Pediatr Orthop. 2022 Jan 01; 42(1):40-46. PMID: 34723893.
      View in: PubMed
    8. Kelly D, Sheffer B, Elrod R, Piana L, Pattisapu N, Nolan V, Spence D, Sawyer J. Infections After Open Fractures in Pediatric Patients: A Review of 288 Open Fractures. J Surg Orthop Adv. 2022; 31(2):73-75. PMID: 35820090.
      View in: PubMed
    9. Bhalla S, Melnekoff DT, Aleman A, Leshchenko V, Restrepo P, Keats J, Onel K, Sawyer JR, Madduri D, Richter J, Richard S, Chari A, Cho HJ, Dudley JT, Jagannath S, Lagan? A, Parekh S. Patient similarity network of newly diagnosed multiple myeloma identifies patient subgroups with distinct genetic features and clinical implications. Sci Adv. 2021 Nov 19; 7(47):eabg9551. PMID: 34788103.
      View in: PubMed
    10. Sawyer JR. Radiation Reduction Strategies in Pediatric Orthopaedics. J Pediatr Orthop. 2021 Jul 01; 41(Suppl 1):S75-S79. PMID: 34096542.
      View in: PubMed
    11. Mohan M, Szabo A, Yarlagadda N, Gundarlapalli S, Thanendrarajan S, Kendrick S, Schinke C, Alapat D, Sawyer J, Tian E, Tricot G, van Rhee F, Zangari M. Persistent bone marrow minimal residual disease as a "high-risk" disease feature in multiple myeloma. Am J Hematol. 2021 09 01; 96(9):E341-E344. PMID: 34050985.
      View in: PubMed
    12. Roye B, Marciano G, Matsumoto H, Fields MW, Campbell M, White KK, Sawyer J, Smith JT, Luhmann S, Sturm P, Sponseller P, Vitale MG. Author's response to letter to the editor regarding "Is rod diameter associated with the rate of rod fracture in patients treated with magnetically controlled growing rods?" Spine Deform. 2021 07; 9(4):1209. PMID: 34057702.
      View in: PubMed
    13. Brown DW, Iorio TJ, Mosher ZA, Beaty JH, Warner WC, Sawyer JR, Spence DD, Sheffer BW, Kelly DM. Intraobserver and Interobserver Reliability of the Peritubercle Lucency Sign in Slipped Capital Femoral Epiphysis. J Pediatr Orthop. 2021 Mar 01; 41(3):159-163. PMID: 33332871.
      View in: PubMed
    14. Stewart RJ, Strickland CD, Sawyer JR, Kumar P, Gungor B, Longjohn M, Kelly DM, Kink RJ. Hunger Games: Impact of Fasting Guidelines for Orthopedic Procedural Sedation in the Pediatric Emergency Department. J Emerg Med. 2021 Apr; 60(4):436-443. PMID: 33323292.
      View in: PubMed
    15. Boyle EM, Ashby C, Tytarenko RG, Deshpande S, Wang H, Wang Y, Rosenthal A, Sawyer J, Tian E, Flynt E, Hoering A, Johnson SK, Rutherford MW, Wardell CP, Bauer MA, Dumontet C, Facon T, Thanendrarajan S, Schinke CD, Zangari M, van Rhee F, Barlogie B, Cairns D, Jackson G, Thakurta A, Davies FE, Morgan GJ, Walker BA. BRAF and DIS3 Mutations Associate with Adverse Outcome in a Long-term Follow-up of Patients with Multiple Myeloma. Clin Cancer Res. 2020 05 15; 26(10):2422-2432. PMID: 31988198.
      View in: PubMed
    16. Mohan M, Weinhold N, Schinke C, Thanedrarajan S, Rasche L, Sawyer JR, Tian E, van Rhee F, Zangari M. Daratumumab in high-risk relapsed/refractory multiple myeloma patients: adverse effect of chromosome 1q21 gain/amplification and GEP70 status on outcome. Br J Haematol. 2020 04; 189(1):67-71. PMID: 31820442.
      View in: PubMed
    17. Sawyer JR, Tian E, Walker BA, Wardell C, Lukacs JL, Sammartino G, Bailey C, Schinke CD, Thanendrarajan S, Davies FE, Morgan GJ, Barlogie B, Zangari M, van Rhee F. An acquired high-risk chromosome instability phenotype in multiple myeloma: Jumping 1q Syndrome. Blood Cancer J. 2019 08 09; 9(8):62. PMID: 31399558.
      View in: PubMed
    18. Ashby C, Tytarenko RG, Wang Y, Weinhold N, Johnson SK, Bauer M, Wardell CP, Schinke C, Thanendrarajan S, Zangari M, van Rhee F, Davies FE, Sawyer JR, Morgan GJ, Walker BA. Poor overall survival in hyperhaploid multiple myeloma is defined by double-hit bi-allelic inactivation of TP53. Oncotarget. 2019 Jan 22; 10(7):732-737. PMID: 30774775.
      View in: PubMed
    19. McKelvey KD, Trana CJ, Kelsay J, Sawyer J, Clothier J. Phelan-McDermid syndrome and cancer predisposition: The value of a karyotype. Am J Med Genet A. 2018 01; 176(1):144-145. PMID: 29210508.
      View in: PubMed
    20. Sawyer JR, Morgan GJ. Hyperhaploid karyotypes in multiple myeloma. Oncotarget. 2017 Oct 03; 8(45):78259-78260. PMID: 29108224.
      View in: PubMed
    21. Jethava YS, Mitchell A, Epstein J, Zangari M, Yaccoby S, Tian E, Waheed S, Khan R, Papanikolaou X, Grazziutti M, Cottler-Fox M, Petty N, Steward D, Panozzo S, Bailey C, Hoering A, Crowley J, Sawyer J, Morgan G, Barlogie B, van Rhee F. Adverse Metaphase Cytogenetics Can Be Overcome by Adding Bortezomib and Thalidomide to Fractionated Melphalan Transplants. Clin Cancer Res. 2017 Jun 01; 23(11):2665-2672. PMID: 27810902.
      View in: PubMed
    22. Tian E, B?rset M, Sawyer JR, Brede G, V?tsveen TK, Hov H, Waage A, Barlogie B, Shaughnessy JD, Epstein J, Sundan A. Allelic mutations in noncoding genomic sequences construct novel transcription factor binding sites that promote gene overexpression. Genes Chromosomes Cancer. 2015 Nov; 54(11):692-701. PMID: 26220195.
      View in: PubMed
    23. Sawyer JR, Tian E, Heuck CJ, Johann DJ, Epstein J, Swanson CM, Lukacs JL, Binz RL, Johnson M, Sammartino G, Zangari M, Davies FE, van Rhee F, Morgan GJ, Barlogie B. Evidence of an epigenetic origin for high-risk 1q21 copy number aberrations in multiple myeloma. Blood. 2015 Jun 11; 125(24):3756-9. PMID: 25943786.
      View in: PubMed
    24. Tian E, Sawyer JR, Heuck CJ, Zhang Q, van Rhee F, Barlogie B, Epstein J. In multiple myeloma, 14q32 translocations are nonrandom chromosomal fusions driving high expression levels of the respective partner genes. Genes Chromosomes Cancer. 2014 Jul; 53(7):549-57. PMID: 24638926.
      View in: PubMed
    25. Sawyer JR, Tian E, Heuck CJ, Epstein J, Johann DJ, Swanson CM, Lukacs JL, Johnson M, Binz R, Boast A, Sammartino G, Usmani S, Zangari M, Waheed S, van Rhee F, Barlogie B. Jumping translocations of 1q12 in multiple myeloma: a novel mechanism for deletion of 17p in cytogenetically defined high-risk disease. Blood. 2014 Apr 17; 123(16):2504-12. PMID: 24497533.
      View in: PubMed
    26. Murphy RF, Beaty JH, Kelly DM, Sawyer JR, Warner WC. Implant Failure in Slipped Capital Femoral Epiphysis: A Report of Two Cases. JBJS Case Connect. 2013 Dec 24; 3(4 Suppl 8):e138. PMID: 29252294.
      View in: PubMed
    27. Usmani SZ, Sawyer J, Rosenthal A, Cottler-Fox M, Epstein J, Yaccoby S, Sexton R, Hoering A, Singh Z, Heuck CJ, Waheed S, Chauhan N, Johann D, Abdallah AO, Muzaffar J, Petty N, Bailey C, Crowley J, van Rhee F, Barlogie B. Risk factors for MDS and acute leukemia following total therapy 2 and 3 for multiple myeloma. Blood. 2013 Jun 06; 121(23):4753-7. PMID: 23603914.
      View in: PubMed
    28. Zhou Y, Zhang Q, Stephens O, Heuck CJ, Tian E, Sawyer JR, Cartron-Mizeracki MA, Qu P, Keller J, Epstein J, Barlogie B, Shaughnessy JD. Prediction of cytogenetic abnormalities with gene expression profiles. Blood. 2012 May 24; 119(21):e148-50. PMID: 22496154.
      View in: PubMed
    29. Sawyer JR, Tian E, Thomas E, Koller M, Stangeby C, Sammartino G, Goosen L, Swanson C, Binz RL, Barlogie B, Shaughnessy J. Evidence for a novel mechanism for gene amplification in multiple myeloma: 1q12 pericentromeric heterochromatin mediates breakage-fusion-bridge cycles of a 1q12 approximately 23 amplicon. Br J Haematol. 2009 Nov; 147(4):484-94. PMID: 19744130.
      View in: PubMed
    30. Barlogie B, Tricot G, Haessler J, van Rhee F, Cottler-Fox M, Anaissie E, Waldron J, Pineda-Roman M, Thertulien R, Zangari M, Hollmig K, Mohiuddin A, Alsayed Y, Hoering A, Crowley J, Sawyer J. Cytogenetically defined myelodysplasia after melphalan-based autotransplantation for multiple myeloma linked to poor hematopoietic stem-cell mobilization: the Arkansas experience in more than 3,000 patients treated since 1989. Blood. 2008 Jan 01; 111(1):94-100. PMID: 17895401.
      View in: PubMed
    31. Shaughnessy JD, Zhan F, Burington BE, Huang Y, Colla S, Hanamura I, Stewart JP, Kordsmeier B, Randolph C, Williams DR, Xiao Y, Xu H, Epstein J, Anaissie E, Krishna SG, Cottler-Fox M, Hollmig K, Mohiuddin A, Pineda-Roman M, Tricot G, van Rhee F, Sawyer J, Alsayed Y, Walker R, Zangari M, Crowley J, Barlogie B. A validated gene expression model of high-risk multiple myeloma is defined by deregulated expression of genes mapping to chromosome 1. Blood. 2007 Mar 15; 109(6):2276-84. PMID: 17105813.
      View in: PubMed
    32. Zhan F, Huang Y, Colla S, Stewart JP, Hanamura I, Gupta S, Epstein J, Yaccoby S, Sawyer J, Burington B, Anaissie E, Hollmig K, Pineda-Roman M, Tricot G, van Rhee F, Walker R, Zangari M, Crowley J, Barlogie B, Shaughnessy JD. The molecular classification of multiple myeloma. Blood. 2006 Sep 15; 108(6):2020-8. PMID: 16728703.
      View in: PubMed
    33. Hanamura I, Stewart JP, Huang Y, Zhan F, Santra M, Sawyer JR, Hollmig K, Zangarri M, Pineda-Roman M, van Rhee F, Cavallo F, Burington B, Crowley J, Tricot G, Barlogie B, Shaughnessy JD. Frequent gain of chromosome band 1q21 in plasma-cell dyscrasias detected by fluorescence in situ hybridization: incidence increases from MGUS to relapsed myeloma and is related to prognosis and disease progression following tandem stem-cell transplantation. Blood. 2006 Sep 01; 108(5):1724-32. PMID: 16705089.
      View in: PubMed
    34. Bergsagel PL, Kuehl WM, Zhan F, Sawyer J, Barlogie B, Shaughnessy J. Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma. Blood. 2005 Jul 01; 106(1):296-303. PMID: 15755896.
      View in: PubMed
    35. Sawyer JR, Tricot G, Mattox S, Jagannath S, Barlogie B. Jumping translocations of chromosome 1q in multiple myeloma: evidence for a mechanism involving decondensation of pericentromeric heterochromatin. Blood. 1998 Mar 01; 91(5):1732-41. PMID: 9473240.
      View in: PubMed
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