Keywords
Last Name
Institution

Robert Reis

TitleProfessor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentGeriatrics, College of Medicine
DivisionGeriatrics Research D
AddressGB105 VA Little Rock
4300 W. 7th
Mail Slot # 151LR
Little Rock AR 72205
Phone501-526-5820
vCardDownload vCard
    Other Positions
    TitleProfessor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentBiochemistry & Molecular Biology, College of Medicine

    TitleProfessor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentInternal Medicine, College of Medicine
    DivisionGeneral Internal Medicine


    Collapse Overview 
    Collapse overview
    My research career has focused on the molecular genetics of longevity and age-associated diseases, using both previously defined mutations and gene mapping combined with bioinformatics approaches. I was trained in Drosophila and mammalian genetics, adding C. elegans in 1989 as a model system in which to develop QTL mapping and thus to define genes that modulate longevity. In mammalian genetics, we were the first to identify the Pirin gene on the X chromosome as a determinant of post-menopausal bone loss in women, a discovery subsequently confirmed in a Chinese population. We also pioneered studies of homologous recombination (HR) and its roles in the etiology and subsequent progression of myeloma, prostate and breast cancers. Data from our laboratory, and subsequently many others, support the hypothesis that HR generates genetic diversity from which more highly oncogenic clones emerge by cell selection. We have focused recently on protein aggregation as a unifying feature of many or all age-dependent diseases and on specific aggregate proteins that appear to play functional roles in the formation or clearance of aggregates. We use proteomics to identify proteins in aggregates of human neurodegenerative diseases; their known or predicted structures allow molecular-dynamic simulations of protein-protein and protein-drug interactions. Predictions from in silico studies are then tested in vivo in models of Alzheimer’s and other human neurodegenerative diseases. Molecular genetics and bioinformatics provide complementary tools to discover and understand causal links.


    Collapse Biography 
    Collapse Leadership and Administrative Roles
    Chair, CAVHS Research and Development Committee (2016 - present)

    Organizing Committee, International Workshop, Genetics of Bone Disease (Davos, Switzerland 2003, 2006)

    Chair of Program Committee and Session Chair, 2nd International Conference on the Genetics of Aging & Longevity (Moscow, 2012)

    Chair of Program Committee and Session Chair, 2nd International Conference on the Genetics of Aging & Longevity (Sochi, 2014)

    Session Chair, Longevity Genes, Cold Spring Harbor Symposium on the Molecular Genetics of Aging (2014)


    Collapse Research Funds 

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Ayyadevara S, Balasubramaniam M, Suri P, Mackintosh SG, Tackett AJ, Sullivan DH, Reis RJ, Dennis RA. Proteins that accumulate with age in human skeletal-muscle aggregates contribute to declines in muscle mass and function in Caenorhabditis elegans. Aging (Albany NY). 2016 Dec 15; 8(12):3486-3497. PMID: 27992858.
      View in: PubMed
    2. Ayyadevara S, Balasubramaniam M, Johnson J, Alla R, Mackintosh SG, Shmookler Reis RJ. PIP3-binding proteins promote age-dependent protein aggregation and limit survival in C. elegans. Oncotarget. 2016 Aug 02; 7(31):48870-48886. PMID: 27429199.
      View in: PubMed
    3. Ayyadevara S, Balasubramaniam M, Parcon PA, Barger SW, Griffin WS, Alla R, Tackett AJ, Mackintosh SG, Petricoin E, Zhou W, Shmookler Reis RJ. Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls. Aging Cell. 2016 Oct; 15(5):924-39. PMID: 27448508.
      View in: PubMed
    4. Ayyadevara S, Mercanti F, Wang X, Mackintosh SG, Tackett AJ, Prayaga SV, Romeo F, Shmookler Reis RJ, Mehta JL. Age- and Hypertension-Associated Protein Aggregates in Mouse Heart Have Similar Proteomic Profiles. Hypertension. 2016 May; 67(5):1006-13. PMID: 26975704; PMCID: PMC4833546 [Available on 05/01/17].
    5. Alagpulinsa DA, Ayyadevara S, Yaccoby S, Shmookler Reis RJ. A Cyclin-Dependent Kinase Inhibitor, Dinaciclib, Impairs Homologous Recombination and Sensitizes Multiple Myeloma Cells to PARP Inhibition. Mol Cancer Ther. 2016 Feb; 15(2):241-50. PMID: 26719576; PMCID: PMC4747838 [Available on 02/01/17].
    6. Kogan V, Molodtsov I, Menshikov LI, Shmookler Reis RJ, Fedichev P. Stability analysis of a model gene network links aging, stress resistance, and negligible senescence. Sci Rep. 2015; 5:13589. PMID: 26316217; PMCID: PMC4551969.
    7. Ding Z, Liu S, Wang X, Deng X, Fan Y, Shahanawaz J, Shmookler Reis RJ, Varughese KI, Sawamura T, Mehta JL. Cross-talk between LOX-1 and PCSK9 in vascular tissues. Cardiovasc Res. 2015 Sep 1; 107(4):556-67. PMID: 26092101.
      View in: PubMed
    8. Alagpulinsa DA, Yaccoby S, Ayyadevara S, Shmookler Reis RJ. A peptide nucleic acid targeting nuclear RAD51 sensitizes multiple myeloma cells to melphalan treatment. Cancer Biol Ther. 2015; 16(6):976-86. PMID: 25996477; PMCID: PMC4622566.
    9. Ayyadevara S, Balasubramaniam M, Gao Y, Yu LR, Alla R, Shmookler Reis R. Proteins in aggregates functionally impact multiple neurodegenerative disease models by forming proteasome-blocking complexes. Aging Cell. 2015 Feb; 14(1):35-48. PMID: 25510159; PMCID: PMC4326912.
    10. Alagpulinsa DA, Ayyadevara S, Shmookler Reis RJ. A Small-Molecule Inhibitor of RAD51 Reduces Homologous Recombination and Sensitizes Multiple Myeloma Cells to Doxorubicin. Front Oncol. 2014; 4:289. PMID: 25401086; PMCID: PMC4214226.
    11. Ayyadevara S, Tazearslan C, Alla R, Jiang JC, Jazwinski SM, Shmookler Reis RJ. Rec-8 dimorphism affects longevity, stress resistance and X-chromosome nondisjunction in C. elegans, and replicative lifespan in S. cerevisiae. Front Genet. 2014; 5:211. PMID: 25136348; PMCID: PMC4120681.
    12. Bharill P, Ayyadevara S, Alla R, Shmookler Reis RJ. Extreme Depletion of PIP3 Accompanies the Increased Life Span and Stress Tolerance of PI3K-null C. elegans Mutants. Front Genet. 2013; 4:34. PMID: 23543623; PMCID: PMC3610087.
    13. Foster SR, Galanzha EI, Totten DC, Beneš H, Shmookler Reis RJ, Zharov VP. Photoacoustically-guided photothermal killing of mosquitoes targeted by nanoparticles. J Biophotonics. 2014 Jul; 7(7):465-73. PMID: 23450780.
      View in: PubMed
    14. Ayyadevara S, Bharill P, Dandapat A, Hu C, Khaidakov M, Mitra S, Shmookler Reis RJ, Mehta JL. Aspirin inhibits oxidant stress, reduces age-associated functional declines, and extends lifespan of Caenorhabditis elegans. Antioxid Redox Signal. 2013 Feb 10; 18(5):481-90. PMID: 22866967.
      View in: PubMed
    15. Shmookler Reis RJ. Coming to terms with complexity: limits to a reductionist view of aging. Front Genet. 2012; 3:149. PMID: 22969788; PMCID: PMC3427912.
    16. Wuttke D, Connor R, Vora C, Craig T, Li Y, Wood S, Vasieva O, Shmookler Reis R, Tang F, de Magalhães JP. Dissecting the gene network of dietary restriction to identify evolutionarily conserved pathways and new functional genes. PLoS Genet. 2012; 8(8):e1002834. PMID: 22912585; PMCID: PMC3415404.
    17. Rose MR, Flatt T, Graves JL, Greer LF, Martinez DE, Matos M, Mueller LD, Shmookler Reis RJ, Shahrestani P. What is Aging? Front Genet. 2012; 3:134. PMID: 22833755; PMCID: PMC3400891.
    18. Nedosekin DA, Galanzha EI, Ayyadevara S, Shmookler Reis RJ, Zharov VP. Photothermal confocal spectromicroscopy of multiple cellular chromophores and fluorophores. Biophys J. 2012 Feb 8; 102(3):672-81. PMID: 22325291; PMCID: PMC3274827.
    19. Shmookler Reis RJ, Ayyadevara S, Crow WA, Lee T, Delongchamp RR. Gene categories differentially expressed in C. elegans age-1 mutants of extraordinary longevity: new insights from novel data-mining procedures. J Gerontol A Biol Sci Med Sci. 2012 Apr; 67(4):366-75. PMID: 22021389.
      View in: PubMed
    20. Vertino A, Ayyadevara S, Thaden JJ, Shmookler Reis RJ. A narrow quantitative trait locus in C. elegans coordinately affects longevity, thermotolerance, and resistance to paraquat. Front Genet. 2011; 2:63. PMID: 22303358; PMCID: PMC3268616.
    21. Pal J, Bertheau R, Buon L, Qazi A, Batchu RB, Bandyopadhyay S, Ali-Fehmi R, Beer DG, Weaver DW, Shmookler Reis RJ, Goyal RK, Huang Q, Munshi NC, Shammas MA. Genomic evolution in Barrett's adenocarcinoma cells: critical roles of elevated hsRAD51, homologous recombination and Alu sequences in the genome. Oncogene. 2011 Aug 18; 30(33):3585-98. PMID: 21423218; PMCID: PMC3406293.
    22. Shmookler Reis RJ, Xu L, Lee H, Chae M, Thaden JJ, Bharill P, Tazearslan C, Siegel E, Alla R, Zimniak P, Ayyadevara S. Modulation of lipid biosynthesis contributes to stress resistance and longevity of C. elegans mutants. Aging (Albany NY). 2011 Feb; 3(2):125-47. PMID: 21386131; PMCID: PMC3082008.
    23. Johnson CH, Ayyadevara S, McEwen JE, Shmookler Reis RJ. Histoplasma capsulatum and Caenorhabditis elegans: a simple nematode model for an innate immune response to fungal infection. Med Mycol. 2009 Dec; 47(8):808-13. PMID: 20028234.
      View in: PubMed
    24. Ayyadevara S, Tazearslan C, Bharill P, Alla R, Siegel E, Shmookler Reis RJ. Caenorhabditis elegans PI3K mutants reveal novel genes underlying exceptional stress resistance and lifespan. Aging Cell. 2009 Dec; 8(6):706-25. PMID: 19764929; PMCID: PMC2917200.
    25. Shmookler Reis RJ, Bharill P, Tazearslan C, Ayyadevara S. Extreme-longevity mutations orchestrate silencing of multiple signaling pathways. Biochim Biophys Acta. 2009 Oct; 1790(10):1075-83. PMID: 19465083; PMCID: PMC2885961.
    26. Tazearslan C, Ayyadevara S, Bharill P, Shmookler Reis RJ. Positive feedback between transcriptional and kinase suppression in nematodes with extraordinary longevity and stress resistance. PLoS Genet. 2009 Apr; 5(4):e1000452. PMID: 19360094; PMCID: PMC2661368.
    27. Shammas MA, Shmookler Reis RJ, Koley H, Batchu RB, Li C, Munshi NC. Dysfunctional homologous recombination mediates genomic instability and progression in myeloma. Blood. 2009 Mar 5; 113(10):2290-7. PMID: 19050310; PMCID: PMC2652372.
    28. Chae M, Shmookler Reis RJ, Thaden JJ. An iterative block-shifting approach to retention time alignment that preserves the shape and area of gas chromatography-mass spectrometry peaks. BMC Bioinformatics. 2008 Aug 12; 9 Suppl 9:S15. PMID: 18793460; PMCID: PMC2537566.
    29. Lee T, Desai VG, Velasco C, Reis RJ, Delongchamp RR. Testing for treatment effects on gene ontology. BMC Bioinformatics. 2008; 9 Suppl 9:S20. PMID: 18793466; PMCID: PMC2537571.
    30. Ayyadevara S, Alla R, Thaden JJ, Shmookler Reis RJ. Remarkable longevity and stress resistance of nematode PI3K-null mutants. Aging Cell. 2008 Jan; 7(1):13-22. PMID: 17996009.
      View in: PubMed
    31. Szumska D, Benes H, Kang P, Weinstein RS, Jilka RL, Manolagas SC, Shmookler Reis RJ. A novel locus on the X chromosome regulates post-maturity bone density changes in mice. Bone. 2007 Mar; 40(3):758-66. PMID: 17185055; PMCID: PMC1861851.
    32. Ayyadevara S, Dandapat A, Singh SP, Siegel ER, Shmookler Reis RJ, Zimniak L, Zimniak P. Life span and stress resistance of Caenorhabditis elegans are differentially affected by glutathione transferases metabolizing 4-hydroxynon-2-enal. Mech Ageing Dev. 2007 Feb; 128(2):196-205. PMID: 17157356; PMCID: PMC1819584.
    33. Khaidakov M, Siegel ER, Shmookler Reis RJ. Direct repeats in mitochondrial DNA and mammalian lifespan. Mech Ageing Dev. 2006 Oct; 127(10):808-12. PMID: 16956646.
      View in: PubMed
    34. Shmookler Reis RJ, Kang P, Ayyadevara S. Quantitative trait loci define genes and pathways underlying genetic variation in longevity. Exp Gerontol. 2006 Oct; 41(10):1046-54. PMID: 16919411.
      View in: PubMed
    35. Ayyadevara S, Dandapat A, Singh SP, Benes H, Zimniak L, Shmookler Reis RJ, Zimniak P. Lifespan extension in hypomorphic daf-2 mutants of Caenorhabditis elegans is partially mediated by glutathione transferase CeGSTP2-2. Aging Cell. 2005 Dec; 4(6):299-307. PMID: 16300482.
      View in: PubMed
    36. Ayyadevara S, Engle MR, Singh SP, Dandapat A, Lichti CF, Benes H, Shmookler Reis RJ, Liebau E, Zimniak P. Lifespan and stress resistance of Caenorhabditis elegans are increased by expression of glutathione transferases capable of metabolizing the lipid peroxidation product 4-hydroxynonenal. Aging Cell. 2005 Oct; 4(5):257-71. PMID: 16164425.
      View in: PubMed
    37. Parsons CA, Mroczkowski HJ, McGuigan FE, Albagha OM, Manolagas S, Reid DM, Ralston SH, Shmookler Reis RJ. Interspecies synteny mapping identifies a quantitative trait locus for bone mineral density on human chromosome Xp22. Hum Mol Genet. 2005 Nov 1; 14(21):3141-8. PMID: 16183656.
      View in: PubMed
    38. Khaidakov M, Shmookler Reis RJ. Possibility of selection against mtDNA mutations in tumors. Mol Cancer. 2005; 4:36. PMID: 16159390; PMCID: PMC1232865.
    39. McEwen JE, Zimniak P, Mehta JL, Shmookler Reis RJ. Molecular pathology of aging and its implications for senescent coronary atherosclerosis. Curr Opin Cardiol. 2005 Sep; 20(5):399-406. PMID: 16093759.
      View in: PubMed
    40. Khaidakov M, Chavannes-Turesky N, Cooney CA, Dupont-Versteegden EE, Kennedy RH, Siegel ER, Khaidakova G, Shmookler Reis RJ. Contribution of de novo point mutations to the overall mutational burden in mitochondrial DNA of adult rats. Exp Gerontol. 2005 May; 40(5):396-402. PMID: 15919591.
      View in: PubMed
    41. Shammas MA, Liu X, Gavory G, Raney KD, Balasubramanian S, Shmookler Reis RJ. Targeting the single-strand G-rich overhang of telomeres with PNA inhibits cell growth and induces apoptosis of human immortal cells. Exp Cell Res. 2004 Apr 15; 295(1):204-14. PMID: 15051503.
      View in: PubMed
    42. Shammas MA, Shmookler Reis RJ, Li C, Koley H, Hurley LH, Anderson KC, Munshi NC. Telomerase inhibition and cell growth arrest after telomestatin treatment in multiple myeloma. Clin Cancer Res. 2004 Jan 15; 10(2):770-6. PMID: 14760100.
      View in: PubMed
    43. Shammas MA, Shmookler Reis RJ, Akiyama M, Koley H, Chauhan D, Hideshima T, Goyal RK, Hurley LH, Anderson KC, Munshi NC. Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in multiple myeloma. Mol Cancer Ther. 2003 Sep; 2(9):825-33. PMID: 14555701.
      View in: PubMed
    44. Shmookler Reis RJ, Ebert RH. Animal models for discovery and assessment of genetic determinants of osteoporosis. Osteoporos Int. 2003 Sep; 14 Suppl 5:S100-6. PMID: 14504713.
      View in: PubMed
    45. Shmookler Reis RJ. From QTL mapping to genes: the long and winding road. J Bone Miner Res. 2003 Feb; 18(2):186-9. PMID: 12568394.
      View in: PubMed
    46. Ayyadevara S, Ayyadevara R, Vertino A, Galecki A, Thaden JJ, Shmookler Reis RJ. Genetic loci modulating fitness and life span in Caenorhabditis elegans: categorical trait interval mapping in CL2a x Bergerac-BO recombinant-inbred worms. Genetics. 2003 Feb; 163(2):557-70. PMID: 12618395; PMCID: PMC1462449.
    47. Miller RA, Galecki A, Shmookler-Reis RJ. Interpretation, design, and analysis of gene array expression experiments. J Gerontol A Biol Sci Med Sci. 2001 Feb; 56(2):B52-7. PMID: 11213267.
      View in: PubMed
    48. Ayyadevara S, Ayyadevara R, Hou S, Thaden JJ, Shmookler Reis RJ. Genetic mapping of quantitative trait loci governing longevity of Caenorhabditis elegans in recombinant-inbred progeny of a Bergerac-BO x RC301 interstrain cross. Genetics. 2001 Feb; 157(2):655-66. PMID: 11156986; PMCID: PMC1461506.
    49. Ayyadevara S, Thaden JJ, Shmookler Reis RJ. Anchor polymerase chain reaction display: a high-throughput method to resolve, score, and isolate dimorphic genetic markers based on interspersed repetitive DNA elements. Anal Biochem. 2000 Aug 15; 284(1):19-28. PMID: 10933851.
      View in: PubMed
    50. Ayyadevara S, Thaden JJ, Shmookler Reis RJ. Discrimination of primer 3'-nucleotide mismatch by taq DNA polymerase during polymerase chain reaction. Anal Biochem. 2000 Aug 15; 284(1):11-8. PMID: 10933850.
      View in: PubMed
    51. Cherkasova V, Ayyadevara S, Egilmez N, Shmookler Reis R. Diverse Caenorhabditis elegans genes that are upregulated in dauer larvae also show elevated transcript levels in long-lived, aged, or starved adults. J Mol Biol. 2000 Jul 14; 300(3):433-48. PMID: 10884342.
      View in: PubMed
    52. Benes H, Weinstein RS, Zheng W, Thaden JJ, Jilka RL, Manolagas SC, Shmookler Reis RJ. Chromosomal mapping of osteopenia-associated quantitative trait loci using closely related mouse strains. J Bone Miner Res. 2000 Apr; 15(4):626-33. PMID: 10780854.
      View in: PubMed
    53. Thaden JJ, Shmookler Reis RJ. Ammonia, respiration, and longevity in nematodes: insights on metabolic regulation of life span from temporal rescaling. J Am Aging Assoc. 2000 Apr; 23(2):75-84. PMID: 23604841; PMCID: PMC3455786.
    54. Shammas MA, Simmons CG, Corey DR, Shmookler Reis RJ. Telomerase inhibition by peptide nucleic acids reverses 'immortality' of transformed human cells. Oncogene. 1999 Nov 4; 18(46):6191-200. PMID: 10597217.
      View in: PubMed
    55. Shammas MA, Shmookler Reis RJ. Recombination and its roles in DNA repair, cellular immortalization and cancer. Age (Omaha). 1999 Apr; 22(2):71-88. PMID: 23604399; PMCID: PMC3455241.
    56. Li J, Ayyadevera R, Shmookler Reis RJ. Carcinogens stimulate intrachromosomal homologous recombination at an endogenous locus in human diploid fibroblasts. Mutat Res. 1997 Dec; 385(3):173-93. PMID: 9506887.
      View in: PubMed
    57. Xia SJ, Shammas MA, Shmookler Reis RJ. Elevated recombination in immortal human cells is mediated by HsRAD51 recombinase. Mol Cell Biol. 1997 Dec; 17(12):7151-8. PMID: 9372947; PMCID: PMC232572.
    58. Lecka-Czernik B, Moerman EJ, Shmookler Reis RJ, Lipschitz DA. Cellular and molecular biomarkers indicate precocious in vitro senescence in fibroblasts from SAMP6 mice. Evidence supporting a murine model of premature senescence and osteopenia. J Gerontol A Biol Sci Med Sci. 1997 Nov; 52(6):B331-6. PMID: 9402934.
      View in: PubMed
    59. Cheng RZ, Shammas MA, Li J, Shmookler Reis RJ. Expression of SV40 large T antigen stimulates reversion of a chromosomal gene duplication in human cells. Exp Cell Res. 1997 Aug 1; 234(2):300-12. PMID: 9260898.
      View in: PubMed
    60. Shammas MA, Xia SJ, Shmookler Reis RJ. Induction of duplication reversion in human fibroblasts, by wild-type and mutated SV40 T antigen, covaries with the ability to induce host DNA synthesis. Genetics. 1997 Aug; 146(4):1417-28. PMID: 9258684; PMCID: PMC1208085.
    61. van Swinderen B, Shook DR, Ebert RH, Cherkasova VA, Johnson TE, Shmookler Reis RJ, Crowder CM. Quantitative trait loci controlling halothane sensitivity in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 1997 Jul 22; 94(15):8232-7. PMID: 9223344; PMCID: PMC21586.
    62. Nikitin AG, Shmookler Reis RJ. Role of transposable elements in age-related genomic instability. Genet Res. 1997 Jun; 69(3):183-95. PMID: 9290321.
      View in: PubMed
    63. Xia SJ, Shammas MA, Shmookler Reis RJ. Reduced telomere length in ataxia-telangiectasia fibroblasts. Mutat Res. 1996 Sep 2; 364(1):1-11. PMID: 8814333.
      View in: PubMed
    64. Shmookler Reis RJ, Ebert RH. Genetics of aging: current animal models. Exp Gerontol. 1996 Jan-Apr; 31(1-2):69-81. PMID: 8706806.
      View in: PubMed
    65. Ebert RH, Shammas MA, Sohal BH, Sohal RS, Egilmez NK, Ruggles S, Shmookler Reis RJ. Defining genes that govern longevity in Caenorhabditis elegans. Dev Genet. 1996; 18(2):131-43. PMID: 8934875.
      View in: PubMed
    66. Egilmez NK, Ebert RH, Shmookler Reis RJ. Strain evolution in Caenorhabditis elegans: transposable elements as markers of interstrain evolutionary history. J Mol Evol. 1995 Apr; 40(4):372-81. PMID: 7769614.
      View in: PubMed
    67. Egilmez NK, Shmookler Reis RJ. Age-dependent somatic excision of transposable element Tc1 in Caenorhabditis elegans. Mutat Res. 1994 Feb; 316(1):17-24. PMID: 7507565.
      View in: PubMed
    68. Ebert RH, Cherkasova VA, Dennis RA, Wu JH, Ruggles S, Perrin TE, Shmookler Reis RJ. Longevity-determining genes in Caenorhabditis elegans: chromosomal mapping of multiple noninteractive loci. Genetics. 1993 Dec; 135(4):1003-10. PMID: 8307318; PMCID: PMC1205733.
    69. Murano S, Thweatt R, Shmookler Reis RJ, Jones RA, Moerman EJ, Goldstein S. Diverse gene sequences are overexpressed in werner syndrome fibroblasts undergoing premature replicative senescence. Mol Cell Biol. 1991 Aug; 11(8):3905-14. PMID: 1712899; PMCID: PMC361182.
    70. Henle KJ, Shmookler Reis RJ, Lumpkin CK. Modulation of cellular glycosidase activity by hyperthermia. Int J Hyperthermia. 1991 May-Jun; 7(3):531-7. PMID: 1833475.
      View in: PubMed
    71. Thweatt R, Goldstein S, Shmookler Reis RJ. A universal primer mixture for sequence determination at the 3' ends of cDNAs. Anal Biochem. 1990 Nov 1; 190(2):314-6. PMID: 2291476.
      View in: PubMed
    72. Cheng RZ, Murano S, Kurz B, Shmookler Reis RJ. Homologous recombination is elevated in some Werner-like syndromes but not during normal in vitro or in vivo senescence of mammalian cells. Mutat Res. 1990 Sep-Nov; 237(5-6):259-69. PMID: 2079965.
      View in: PubMed
    73. Goldstein S, Jones RA, Hardin JW, Braunstein GD, Shmookler Reis RJ. Expression of alpha- and beta-human chorionic gonadotropin subunits in cultured human cells. In Vitro Cell Dev Biol. 1990 Sep; 26(9):857-64. PMID: 1699921.
      View in: PubMed
    74. Srivastava A, Shmookler Reis RJ, Goldstein S. Absence of reverse transcriptase activity in human diploid fibroblasts. Mech Ageing Dev. 1990 Feb 1; 51(2):133-8. PMID: 1689785.
      View in: PubMed
    75. Goldstein S, Murano S, Shmookler Reis RJ. Werner syndrome: a molecular genetic hypothesis. J Gerontol. 1990 Jan; 45(1):B3-8. PMID: 2404059.
      View in: PubMed
    76. Shmookler Reis RJ, Finn GK, Smith K, Goldstein S. Clonal variation in gene methylation: c-H-ras and alpha-hCG regions vary independently in human fibroblast lineages. Mutat Res. 1990 Jan; 237(1):45-57. PMID: 2157149.
      View in: PubMed
    77. Houde M, Shmookler Reis RJ, Goldstein S. Proportions of H1 histone subspecies in human fibroblasts shift during density-dependent growth arrest independent of replicative senescence. Exp Cell Res. 1989 Sep; 184(1):256-61. PMID: 2792226.
      View in: PubMed
    78. Finn GK, Kurz BW, Cheng RZ, Shmookler Reis RJ. Homologous plasmid recombination is elevated in immortally transformed cells. Mol Cell Biol. 1989 Sep; 9(9):4009-17. PMID: 2550810; PMCID: PMC362463.
    79. Shmookler Reis RJ. Model systems for aging research: syncretic concepts and diversity of mechanisms. Genome. 1989; 31(1):406-12. PMID: 2687106.
      View in: PubMed
    80. Shmookler Reis RJ. Strategies and criteria for the development of molecular biomarkers of senescence. Exp Gerontol. 1988; 23(4-5):271-80. PMID: 3058490.
      View in: PubMed
    81. Shmookler Reis RJ, Srivastava A, Beranek DT, Goldstein S. Human alphoid family of tandemly repeated DNA. Sequence of cloned tetrameric fragments and analysis of familial divergence. J Mol Biol. 1985 Nov 5; 186(1):31-41. PMID: 3001316.
      View in: PubMed
    82. Goldstein S, Shmookler Reis RJ. Methylation patterns in the gene for the alpha subunit of chorionic gonadotropin are inherited with variable fidelity in clonal lineages of human fibroblasts. Nucleic Acids Res. 1985 Oct 11; 13(19):7055-65. PMID: 4059053; PMCID: PMC322022.
    83. Srivastava A, Norris JS, Shmookler Reis RJ, Goldstein S. c-Ha-ras-1 proto-oncogene amplification and overexpression during the limited replicative life span of normal human fibroblasts. J Biol Chem. 1985 May 25; 260(10):6404-9. PMID: 3997829.
      View in: PubMed
    84. Shmookler Reis RJ, Goldstein S. Mitochondrial DNA in mortal and immortal human cells. Genome number, integrity, and methylation. J Biol Chem. 1983 Aug 10; 258(15):9078-85. PMID: 6307991.
      View in: PubMed
    85. Shmookler Reis RJ, Lumpkin CK, McGill JR, Riabowol KT, Goldstein S. Extrachromosomal circular copies of an 'inter-Alu' unstable sequence in human DNA are amplified during in vitro and in vivo ageing. Nature. 1983 Feb 3; 301(5899):394-8. PMID: 6823315.
      View in: PubMed
    86. Shmookler Reis RJ, Goldstein S. Interclonal variation in methylation patterns for expressed and non-expressed genes. Nucleic Acids Res. 1982 Jul 24; 10(14):4293-304. PMID: 6896910; PMCID: PMC320800.
    87. Shmookler Reis RJ, Goldstein S. Variability of DNA methylation patterns during serial passage of human diploid fibroblasts. Proc Natl Acad Sci U S A. 1982 Jul; 79(13):3949-53. PMID: 6287455; PMCID: PMC346553.
    88. Harley CB, Shmookler Reis RJ, Goldstein S. Loss of repetitious DNA in proliferating somatic cells may be due to unequal recombination. J Theor Biol. 1982 Jan 7; 94(1):1-12. PMID: 7078201.
      View in: PubMed
    89. Shmookler Reis RJ. Ribosomes from aging mice are not generally deficient in cell-free protein synthesis. Mech Ageing Dev. 1981 Dec; 17(4):311-20. PMID: 7329100.
      View in: PubMed
    Reis's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description
    Physical Neighbors Expand Description
    _