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Robert Reis

TitleProfessor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentGeriatrics, College of Medicine
DivisionGeriatrics Faculty
AddressGB105 VA Little Rock
629 Jack Stephens Drive
Mail Slot # 151LR
Little Rock AR 72205
Phone501-526-5820
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    Other Positions
    TitleProfessor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentBiochemistry & Molecular Biology, College of Medicine

    TitleProfessor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentInternal Medicine, College of Medicine
    DivisionGeneral Internal Medicine

    Other Roles
    Sr. Research Career Scientist, Central Arkansas Veterans Healthcare System, Little Rock AR
    Affiliate Professor, Pathology Dept., Univ. of Washington Medical School, Seattle WA

    Collapse Overview 
    Collapse overview
    My research group has been focused for the last 5 years on two areas: (1.) the role of PI 3-kinase in insulin-like signaling and extreme longevity, extending to a 10-fold increase in lifespan for C. elegans nematodes carrying a null mutation; and (2.) protein aggregation as a unifying feature of many or all age-progressive diseases. We have pursued specific aggregate proteins that favor the formation of aggregates (by promoting protein coallescence) or disrupt their clearance (through interference with proteasomes and autophagosomes). We use proteomics to identify proteins in aggregates of Alzheimer's and other human neurodegenerative diseases; their known or predicted structures allow molecular-dynamic simulations of protein-protein and protein-drug interactions. Predictions from in silico studies are then tested in vivo using models of Alzheimer’s and other human neurodegenerative diseases, in the nematode C. elegans, in cultured human cells, and in mouse models of neuropathy. Molecular genetics and bioinformatics provide complementary tools to discover and understand functional interactions.

    Water under the bridge (previous research):
    From the start of my research career, I have been fascinated by the genetic regulation of longevity and age-associated diseases. My group characterized a number of mutations that have large effects on lifespan in the nematode C. elegans. We also used gene mapping combined with bioinformatics approaches to discover and characterize the natural variation in genes that modulate lifespan. We found that Rec-8 protein (a cohesin) alters lifespan in nematodes and yeast, and a colleague then showed that it also contributed to the exceptional longevity of bowhead whales. In mammalian genetics, we were the first to identify the Pirin gene on the X chromosome as a determinant of post-menopausal bone loss in women, a discovery subsequently confirmed in a Chinese population. We also pioneered studies of homologous recombination (HR) and its roles in the etiology and subsequent progression of myeloma, prostate and breast cancers. Data from our laboratory, and subsequently many others, support the hypothesis that HR generates genetic diversity from which more highly oncogenic clones emerge by cell selection. We have exploited the heavy dependence of cancer cells on HR to develop synergistic combinations of chemotherapeutic drugs.


    Collapse Biography 
    Collapse Leadership and Administrative Roles
    Chair, 9 NIH/NIA Review Boards and site-visit teams (1987, 2006, 2011, 2013, 2017, 2018); member of 30 NIH/NIA Initial Review Board meetings (1983 - present).

    Chair, CAVHS Research and Development Committee (2016 - present)

    Chair, CAVHS Strategic Planning Committee (2018 - present)

    Member, 10 Merit Review, Career Development, Promotion, and Research Career Scientist review boards (2000 - present)

    Associate Editor, Frontiers in Genetics (2014 - present)

    Session Chair, Longevity Genes, Cold Spring Harbor Symposium on the Molecular Genetics of Aging (2014)

    Chair of Program Committee and Session Chair, 3rd International Conference on the Genetics of Aging & Longevity (Sochi, 2014)

    Chair of Program Committee and Session Chair, 2nd International Conference on the Genetics of Aging & Longevity (Moscow, 2012)

    Organizing Committee, International Workshop, Genetics of Bone Disease (Davos, Switzerland 2003, 2006)

    Collapse education and training
    Harvard University, Cambridge, Mass. USAB.A.1967Biology
    University of Sussex, Falmer, England, U.K.D.Phil. (Ph.D.)1972Genetics

    Collapse Research 
    Collapse research activities and funding
    I01 BX006445     (Robert J. Shmookler Reis)Oct 1, 2024 - Sep 30, 2028
    VA (I01 Dept. of Veterans Affairs)
    Repurposing FDA-approved drugs to disrupt tau- and amyloid-associated protein-protein interactions in Alzheimer's disease aggregates
    Role Description: These studies pursue preclinical research on drugs designed to disrupt Alzheimer's disease aggregation.
    Role: Principal Investigator

    I01 BX006445     (Robert J. Shmookler Reis)Oct 1, 2019 - Sep 30, 2026
    VA (Dept. of Veterans Affairs)
    Senior Research Career Scientist Award
    Role Description: The RCSA is a merit-based award to support basic research by VA career scientists.
    Role: Principal Investigator

    R01AG062254     (REIS, ROBERT J)Sep 30, 2018 - May 31, 2024
    NIH/Nat. Inst. on Aging
    Inference of Common Pathways Underlying Neurodegeneration & Other Age-Progressive Diseases - Continuation - Continuation
    Role: Principal Investigator

    R01AG062254     (REIS, ROBERT)Sep 30, 2018 - May 31, 2023
    NIH/Nat. Inst. on Aging
    Inference of Common Pathways Underlying Neurodegeneration & Other Age-Progressive Diseases
    Role: Principal Investigator

    P01 AG012411 (S. Griffin, P.I.)     (REIS, ROBERT J)Sep 1, 2016 - May 31, 2021
    NIH/NIA
    Roles of protein aggregation in Alzheimer’s and other neurodegenerative diseases
    Role: Principal Investigator

    C22454     (REIS, ROBERT J)May 19, 2016 - May 18, 2021
    Quantum Pharmaceuticals Ltd
    No FP attached
    Role: Principal Investigator

    1556068     (ZHAROV, VLADIMIR P)Mar 15, 2016 - Feb 28, 2021
    National Science Foundation
    IDBR: TYPE A. Far-field optical thermal wave nanoscopy- Resubmission - Continuation - Continuation
    Role: Co-Investigator

    P20GM109005     (BOERMA, MARJAN)Jun 24, 2015 - May 31, 2025
    NIH
    Center for Studies of Host Response to Cancer Therapy
    Role: Co-Investigator

    BX001655 (VA Merit)     (REIS, ROBERT J)Apr 1, 2013 - Mar 30, 2022
    Veterans Administration
    Analysis and Therapy of Age-Dependent Proteostasis Failure in Neurodegeneration
    Role: Principal Investigator

    Reis SRCSA     (REIS, ROBERT J)Oct 1, 2012 - Sep 30, 2019
    Veterans Administration
    Senior Research Career Scientist Award
    Role: Principal Investigator

    P30AG028718     (WEI, JEANNE Y)Sep 1, 2011 - Aug 31, 2018
    NIH
    Arkansas Claude Pepper Older Americans Independence Center at UAMS
    Role: Co-Investigator

    R01AG028088     (ZIMNIAK, PIOTR)Feb 1, 2007 - Oct 31, 2012
    NIH
    Role of glutathione transferases in life span extension of C. elegans
    Role: Co-Investigator

    P01AG020641     (REIS, ROBERT J)Feb 15, 2003 - Jan 31, 2008
    NIH/Nat. Inst. on Aging
    Metabolic Mechanisms Limiting and Protecting Longevity
    Role: Principal Investigator

    P01AG012411     (GRIFFIN, SUE TILTON)Jun 1, 1995 - May 31, 2021
    NIH
    Early Events in Alzheimer Pathogenesis
    Role: Co-Principal Investigator

    R01AG09413     (REIS, ROBERT J)Aug 15, 1991 - Nov 30, 2001
    NIH/Nat. Inst. on Aging
    Polymorphic Genes Modulating Lifespan in C Elegans
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Guareschi AS, Gannon ST, Welsh ME, Reis RJ, Wright TW, King JJ, Papandrea RF, Simovitch RW, Friedman RJ, Eichinger JK. Outcomes following Humeral Head Autograft Glenoid Reconstruction in Primary Reverse Total Shoulder Arthroplasty. J Shoulder Elbow Surg. 2024 Aug 16. PMID: 39154848.
      View in: PubMed
    2. Mazur A, Ayyadevara S, Mainali N, Patchett S, Uden M, Roa RI, Fahy GM, Shmookler Reis RJ. Model biological systems demonstrate the inducibility of pathways that strongly reduce cryoprotectant toxicity. Cryobiology. 2024 Jun; 115:104881. PMID: 38437899.
      View in: PubMed
    3. Mainali N, Balasubramaniam M, Johnson J, Ayyadevara S, Shmookler Reis RJ. Leave-one-out-analysis (LOOA): web-based tool to predict influential proteins and interactions in aggregate-crosslinking proteomic data. Bioinformation. 2024; 20(1):4-10. PMID: 38352912.
      View in: PubMed
    4. Balasubramaniam M, Narasimhappagari J, Liu L, Ganne A, Ayyadevara S, Atluri R, Ayyadevara H, Caldwell G, Shmookler Reis RJ, Barger SW, Griffin WST. Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer's disease by targeted small molecules. Commun Biol. 2024 01 08; 7(1):60. PMID: 38191671.
      View in: PubMed
    5. Walton C, Reis RJ, Welsh ME, Friedman RJ, Eichinger JK. Ulnar Collateral Ligament Repair With Internal Brace Using Linked Knotless Suture Anchors. Arthrosc Tech. 2024 Mar; 13(3):102874. PMID: 38584631.
      View in: PubMed
    6. Balasubramaniam M, Ganne A, Mainali N, Pahal S, Ayyadevara S, Shmookler Reis RJ. Alzheimer's-specific brain amyloid interactome: Neural-network analysis of intra-aggregate crosslinking identifies novel drug targets. iScience. 2024 Jan 19; 27(1):108745. PMID: 38274404.
      View in: PubMed
    7. Mainali N, Li X, Wang X, Balasubramaniam M, Ganne A, Kore R, Shmookler Reis RJ, Mehta JL, Ayyadevara S. Myocardial infarction elevates endoplasmic reticulum stress and protein aggregation in heart as well as brain. Mol Cell Biochem. 2023 Nov 03. PMID: 37922111.
      View in: PubMed
    8. Kakraba S, Ayyadevara S, Mainali N, Balasubramaniam M, Bowroju S, Penthala NR, Atluri R, Barger SW, Griffin ST, Crooks PA, Shmookler Reis RJ. Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan. Pharmaceuticals (Basel). 2023 Oct 20; 16(10). PMID: 37895969.
      View in: PubMed
    9. Mainali N, Ayyadevara S, Ganne A, Shmookler Reis RJ, Mehta JL. Protein homeostasis in the aged and diseased heart. J Cardiovasc Aging. 2023; 3(2). PMID: 37092014.
      View in: PubMed
    10. Ganne A, Balasubramaniam M, Ayyadevara H, Kiaei L, Shmookler Reis RJ, Varughese KI, Kiaei M. In silico analysis of TUBA4A mutations in Amyotrophic Lateral Sclerosis to define mechanisms of microtubule disintegration. Sci Rep. 2023 02 06; 13(1):2096. PMID: 36747013.
      View in: PubMed
    11. Ganne A, Balasubramaniam M, Mainali N, Atluri P, Shmookler Reis RJ, Ayyadevara S. Physiological Consequences of Targeting 14-3-3 and Its Interacting Partners in Neurodegenerative Diseases. Int J Mol Sci. 2022 Dec 07; 23(24). PMID: 36555098.
      View in: PubMed
    12. Ganne A, Balasubramaniam M, Ayyadevara S, Shmookler Reis RJ. Machine-learning analysis of intrinsically disordered proteins identifies key factors that contribute to neurodegeneration-related aggregation. Front Aging Neurosci. 2022; 14:938117. PMID: 35992603.
      View in: PubMed
    13. Ganne A, Balasubramaniam M, Griffin WST, Shmookler Reis RJ, Ayyadevara S. Glial Fibrillary Acidic Protein: A Biomarker and Drug Target for Alzheimer's Disease. Pharmaceutics. 2022 Jun 26; 14(7). PMID: 35890250.
      View in: PubMed
    14. Alagpulinsa DA, Toribio MP, Alhallak I, Shmookler Reis RJ. Advances in understanding the molecular basis of clonal hematopoiesis. Trends Mol Med. 2022 05; 28(5):360-377. PMID: 35341686.
      View in: PubMed
    15. Nedosekin DA, Chen T, Ayyadevara S, Zharov VP, Shmookler Reis RJ. Label-free photothermal disruption of cytotoxic aggregates rescues pathology in a C. elegans model of Huntington's disease. Sci Rep. 2021 10 05; 11(1):19732. PMID: 34611196.
      View in: PubMed
    16. Ayyadevara S, Ganne A, Balasubramaniam M, Shmookler Reis RJ. Intrinsically disordered proteins identified in the aggregate proteome serve as biomarkers of neurodegeneration. Metab Brain Dis. 2022 01; 37(1):147-152. PMID: 34347206.
      View in: PubMed
    17. Bowroju SK, Penthala NR, Lakkaniga NR, Balasubramaniam M, Ayyadevara S, Shmookler Reis RJ, Crooks PA. Novel hydroxybenzylamine-deoxyvasicinone hybrids as anticholinesterase therapeutics for Alzheimer's disease. Bioorg Med Chem. 2021 09 01; 45:116311. PMID: 34304133.
      View in: PubMed
    18. Shmookler Reis RJ, Atluri R, Balasubramaniam M, Johnson J, Ganne A, Ayyadevara S. "Protein aggregates" contain RNA and DNA, entrapped by misfolded proteins but largely rescued by slowing translational elongation. Aging Cell. 2021 05; 20(5):e13326. PMID: 33788386.
      View in: PubMed
    19. Balasubramaniam M, Mainali N, Bowroju SK, Atluri P, Penthala NR, Ayyadevera S, Crooks PA, Shmookler Reis RJ. Structural modeling of GSK3? implicates the inactive (DFG-out) conformation as the target bound by TDZD analogs. Sci Rep. 2020 10 27; 10(1):18326. PMID: 33110096.
      View in: PubMed
    20. Bowroju SK, Mainali N, Ayyadevara S, Penthala NR, Krishnamachari S, Kakraba S, Shmookler Reis RJ, Crooks PA. Design and Synthesis of Novel Hybrid 8-Hydroxy Quinoline-Indole Derivatives as Inhibitors of A? Self-Aggregation and Metal Chelation-Induced A? Aggregation. Molecules. 2020 08 08; 25(16). PMID: 32784464.
      View in: PubMed
    21. Alagpulinsa DA, Szalat RE, Poznansky MC, Shmookler Reis RJ. Genomic Instability in Multiple Myeloma. Trends Cancer. 2020 10; 6(10):858-873. PMID: 32487486.
      View in: PubMed
    22. Balasubramaniam M, Reis RJS. Computational target-based drug repurposing of elbasvir, an antiviral drug predicted to bind multiple SARS-CoV-2 proteins. ChemRxiv. 2020 Apr 08. PMID: 32511290.
      View in: PubMed
    23. Kakraba S, Ayyadevara S, Penthala NR, Balasubramaniam M, Ganne A, Liu L, Alla R, Bommagani SB, Barger SW, Griffin WST, Crooks PA, Shmookler Reis RJ. A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer's Disease. Front Mol Neurosci. 2019; 12:310. PMID: 31920540.
      View in: PubMed
    24. Balasubramaniam M, Ayyadevara S, Ganne A, Kakraba S, Penthala NR, Du X, Crooks PA, Griffin ST, Shmookler Reis RJ. Aggregate Interactome Based on Protein Cross-linking Interfaces Predicts Drug Targets to Limit Aggregation in Neurodegenerative Diseases. iScience. 2019 Oct 25; 20:248-264. PMID: 31593839.
      View in: PubMed
    25. Tarkhov AE, Alla R, Ayyadevara S, Pyatnitskiy M, Menshikov LI, Shmookler Reis RJ, Fedichev PO. A universal transcriptomic signature of age reveals the temporal scaling of Caenorhabditis elegans aging trajectories. Sci Rep. 2019 05 14; 9(1):7368. PMID: 31089188.
      View in: PubMed
    26. Ayyadevara S, Ganne A, Hendrix RD, Balasubramaniam M, Shmookler Reis RJ, Barger SW. Functional assessments through novel proteomics approaches: Application to insulin/IGF signaling in neurodegenerative disease'. J Neurosci Methods. 2019 05 01; 319:40-46. PMID: 30412730.
      View in: PubMed
    27. Balasubramaniam M, Ayyadevara S, Shmookler Reis RJ. Structural insights into pro-aggregation effects of C. elegans CRAM-1 and its human ortholog SERF2. Sci Rep. 2018 10 05; 8(1):14891. PMID: 30291272.
      View in: PubMed
    28. Kiaei M, Balasubramaniam M, Govind Kumar V, Shmookler Reis RJ, Moradi M, Varughese KI. ALS-causing mutations in profilin-1 alter its conformational dynamics: A computational approach to explain propensity for aggregation. Sci Rep. 2018 08 30; 8(1):13102. PMID: 30166578.
      View in: PubMed
    29. Parcon PA, Balasubramaniam M, Ayyadevara S, Jones RA, Liu L, Shmookler Reis RJ, Barger SW, Mrak RE, Griffin WST. Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs. Alzheimers Dement. 2018 02; 14(2):230-242. PMID: 28945989.
      View in: PubMed
    30. Balasubramaniam M, Shmookler Reis RJ, Ayyadevara S, Wang X, Ganne A, Khaidakov M. Involvement of tRNAs in replication of human mitochondrial DNA and modifying effects of telomerase. Mech Ageing Dev. 2017 09; 166:55-63. PMID: 28765009.
      View in: PubMed
    31. Ayyadevara S, Balasubramaniam M, Kakraba S, Alla R, Mehta JL, Shmookler Reis RJ. Aspirin-Mediated Acetylation Protects Against Multiple Neurodegenerative Pathologies by Impeding Protein Aggregation. Antioxid Redox Signal. 2017 Dec 10; 27(17):1383-1396. PMID: 28537433.
      View in: PubMed
    32. Ayyadevara S, Balasubramaniam M, Suri P, Mackintosh SG, Tackett AJ, Sullivan DH, Shmookler Reis RJ, Dennis RA. Proteins that accumulate with age in human skeletal-muscle aggregates contribute to declines in muscle mass and function in Caenorhabditis elegans. Aging (Albany NY). 2016 12 15; 8(12):3486-3497. PMID: 27992858.
      View in: PubMed
    33. Ayyadevara S, Balasubramaniam M, Johnson J, Alla R, Mackintosh SG, Shmookler Reis RJ. PIP3-binding proteins promote age-dependent protein aggregation and limit survival in C. elegans. Oncotarget. 2016 Aug 02; 7(31):48870-48886. PMID: 27429199.
      View in: PubMed
    34. Ayyadevara S, Balasubramaniam M, Parcon PA, Barger SW, Griffin WS, Alla R, Tackett AJ, Mackintosh SG, Petricoin E, Zhou W, Shmookler Reis RJ. Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls. Aging Cell. 2016 10; 15(5):924-39. PMID: 27448508.
      View in: PubMed
    35. Ayyadevara S, Mercanti F, Wang X, Mackintosh SG, Tackett AJ, Prayaga SV, Romeo F, Shmookler Reis RJ, Mehta JL. Age- and Hypertension-Associated Protein Aggregates in Mouse Heart Have Similar Proteomic Profiles. Hypertension. 2016 May; 67(5):1006-13. PMID: 26975704.
      View in: PubMed
    36. Alagpulinsa DA, Ayyadevara S, Yaccoby S, Shmookler Reis RJ. A Cyclin-Dependent Kinase Inhibitor, Dinaciclib, Impairs Homologous Recombination and Sensitizes Multiple Myeloma Cells to PARP Inhibition. Mol Cancer Ther. 2016 Feb; 15(2):241-50. PMID: 26719576.
      View in: PubMed
    37. Kogan V, Molodtsov I, Menshikov LI, Shmookler Reis RJ, Fedichev P. Stability analysis of a model gene network links aging, stress resistance, and negligible senescence. Sci Rep. 2015 Aug 28; 5:13589. PMID: 26316217.
      View in: PubMed
    38. Ding Z, Liu S, Wang X, Deng X, Fan Y, Shahanawaz J, Shmookler Reis RJ, Varughese KI, Sawamura T, Mehta JL. Cross-talk between LOX-1 and PCSK9 in vascular tissues. Cardiovasc Res. 2015 Sep 01; 107(4):556-67. PMID: 26092101.
      View in: PubMed
    39. Alagpulinsa DA, Yaccoby S, Ayyadevara S, Shmookler Reis RJ. A peptide nucleic acid targeting nuclear RAD51 sensitizes multiple myeloma cells to melphalan treatment. Cancer Biol Ther. 2015; 16(6):976-86. PMID: 25996477.
      View in: PubMed
    40. Ayyadevara S, Balasubramaniam M, Gao Y, Yu LR, Alla R, Shmookler Reis R. Proteins in aggregates functionally impact multiple neurodegenerative disease models by forming proteasome-blocking complexes. Aging Cell. 2015 Feb; 14(1):35-48. PMID: 25510159.
      View in: PubMed
    41. Alagpulinsa DA, Ayyadevara S, Shmookler Reis RJ. A Small-Molecule Inhibitor of RAD51 Reduces Homologous Recombination and Sensitizes Multiple Myeloma Cells to Doxorubicin. Front Oncol. 2014; 4:289. PMID: 25401086.
      View in: PubMed
    42. Ayyadevara S, Tazearslan C, Alla R, Jiang JC, Jazwinski SM, Shmookler Reis RJ. Rec-8 dimorphism affects longevity, stress resistance and X-chromosome nondisjunction in C. elegans, and replicative lifespan in S. cerevisiae. Front Genet. 2014; 5:211. PMID: 25136348.
      View in: PubMed
    43. Bharill P, Ayyadevara S, Alla R, Shmookler Reis RJ. Extreme Depletion of PIP3 Accompanies the Increased Life Span and Stress Tolerance of PI3K-null C. elegans Mutants. Front Genet. 2013; 4:34. PMID: 23543623.
      View in: PubMed
    44. Foster SR, Galanzha EI, Totten DC, Bene? H, Shmookler Reis RJ, Zharov VP. Photoacoustically-guided photothermal killing of mosquitoes targeted by nanoparticles. J Biophotonics. 2014 Jul; 7(7):465-73. PMID: 23450780.
      View in: PubMed
    45. Ayyadevara S, Bharill P, Dandapat A, Hu C, Khaidakov M, Mitra S, Shmookler Reis RJ, Mehta JL. Aspirin inhibits oxidant stress, reduces age-associated functional declines, and extends lifespan of Caenorhabditis elegans. Antioxid Redox Signal. 2013 Feb 10; 18(5):481-90. PMID: 22866967.
      View in: PubMed
    46. Shmookler Reis RJ. Coming to terms with complexity: limits to a reductionist view of aging. Front Genet. 2012; 3:149. PMID: 22969788.
      View in: PubMed
    47. Wuttke D, Connor R, Vora C, Craig T, Li Y, Wood S, Vasieva O, Shmookler Reis R, Tang F, de Magalh?es JP. Dissecting the gene network of dietary restriction to identify evolutionarily conserved pathways and new functional genes. PLoS Genet. 2012; 8(8):e1002834. PMID: 22912585.
      View in: PubMed
    48. Rose MR, Flatt T, Graves JL, Greer LF, Martinez DE, Matos M, Mueller LD, Shmookler Reis RJ, Shahrestani P. What is Aging? Front Genet. 2012; 3:134. PMID: 22833755.
      View in: PubMed
    49. Anisimov VN, Bartke A, Barzilai N, Batin MA, Blagosklonny MV, Brown-Borg H, Budovskaya Y, Campisi J, Friguet B, Fraifeld V, Franceschi C, Gems D, Gladyshev V, Gorbunova V, Gudkov AV, Kennedy B, Konovalenko M, Kraemer B, Moskalev A, Petropoulos I, Pasyukova E, Rattan S, Rogina B, Seluanov A, Shaposhnikov M, Shmookler Reis R, Tavernarakis N, Vijg J, Yashin A, Zimniak P. The second international conference "genetics of aging and longevity". Aging (Albany NY). 2012 May; 4(5):305-17. PMID: 22661237.
      View in: PubMed
    50. Nedosekin DA, Galanzha EI, Ayyadevara S, Shmookler Reis RJ, Zharov VP. Photothermal confocal spectromicroscopy of multiple cellular chromophores and fluorophores. Biophys J. 2012 Feb 08; 102(3):672-81. PMID: 22325291.
      View in: PubMed
    51. Shmookler Reis RJ, Ayyadevara S, Crow WA, Lee T, Delongchamp RR. Gene categories differentially expressed in C. elegans age-1 mutants of extraordinary longevity: new insights from novel data-mining procedures. J Gerontol A Biol Sci Med Sci. 2012 Apr; 67(4):366-75. PMID: 22021389.
      View in: PubMed
    52. Vertino A, Ayyadevara S, Thaden JJ, Shmookler Reis RJ. A narrow quantitative trait locus in C. elegans coordinately affects longevity, thermotolerance, and resistance to paraquat. Front Genet. 2011; 2:63. PMID: 22303358.
      View in: PubMed
    53. Pal J, Bertheau R, Buon L, Qazi A, Batchu RB, Bandyopadhyay S, Ali-Fehmi R, Beer DG, Weaver DW, Shmookler Reis RJ, Goyal RK, Huang Q, Munshi NC, Shammas MA. Genomic evolution in Barrett's adenocarcinoma cells: critical roles of elevated hsRAD51, homologous recombination and Alu sequences in the genome. Oncogene. 2011 Aug 18; 30(33):3585-98. PMID: 21423218.
      View in: PubMed
    54. Shmookler Reis RJ, Xu L, Lee H, Chae M, Thaden JJ, Bharill P, Tazearslan C, Siegel E, Alla R, Zimniak P, Ayyadevara S. Modulation of lipid biosynthesis contributes to stress resistance and longevity of C. elegans mutants. Aging (Albany NY). 2011 Feb; 3(2):125-47. PMID: 21386131.
      View in: PubMed
    55. Johnson CH, Ayyadevara S, McEwen JE, Shmookler Reis RJ. Histoplasma capsulatum and Caenorhabditis elegans: a simple nematode model for an innate immune response to fungal infection. Med Mycol. 2009 Dec; 47(8):808-13. PMID: 20028234.
      View in: PubMed
    56. Ayyadevara S, Tazearslan C, Bharill P, Alla R, Siegel E, Shmookler Reis RJ. Caenorhabditis elegans PI3K mutants reveal novel genes underlying exceptional stress resistance and lifespan. Aging Cell. 2009 Dec; 8(6):706-25. PMID: 19764929.
      View in: PubMed
    57. Shmookler Reis RJ, Bharill P, Tazearslan C, Ayyadevara S. Extreme-longevity mutations orchestrate silencing of multiple signaling pathways. Biochim Biophys Acta. 2009 Oct; 1790(10):1075-83. PMID: 19465083.
      View in: PubMed
    58. Tazearslan C, Ayyadevara S, Bharill P, Shmookler Reis RJ. Positive feedback between transcriptional and kinase suppression in nematodes with extraordinary longevity and stress resistance. PLoS Genet. 2009 Apr; 5(4):e1000452. PMID: 19360094.
      View in: PubMed
    59. Shammas MA, Shmookler Reis RJ, Koley H, Batchu RB, Li C, Munshi NC. Dysfunctional homologous recombination mediates genomic instability and progression in myeloma. Blood. 2009 Mar 05; 113(10):2290-7. PMID: 19050310.
      View in: PubMed
    60. Chae M, Shmookler Reis RJ, Thaden JJ. An iterative block-shifting approach to retention time alignment that preserves the shape and area of gas chromatography-mass spectrometry peaks. BMC Bioinformatics. 2008 Aug 12; 9 Suppl 9:S15. PMID: 18793460.
      View in: PubMed
    61. Lee T, Desai VG, Velasco C, Reis RJ, Delongchamp RR. Testing for treatment effects on gene ontology. BMC Bioinformatics. 2008 Aug 12; 9 Suppl 9:S20. PMID: 18793466.
      View in: PubMed
    62. Ayyadevara S, Alla R, Thaden JJ, Shmookler Reis RJ. Remarkable longevity and stress resistance of nematode PI3K-null mutants. Aging Cell. 2008 Jan; 7(1):13-22. PMID: 17996009.
      View in: PubMed
    63. Szumska D, Benes H, Kang P, Weinstein RS, Jilka RL, Manolagas SC, Shmookler Reis RJ. A novel locus on the X chromosome regulates post-maturity bone density changes in mice. Bone. 2007 Mar; 40(3):758-66. PMID: 17185055.
      View in: PubMed
    64. Ayyadevara S, Dandapat A, Singh SP, Siegel ER, Shmookler Reis RJ, Zimniak L, Zimniak P. Life span and stress resistance of Caenorhabditis elegans are differentially affected by glutathione transferases metabolizing 4-hydroxynon-2-enal. Mech Ageing Dev. 2007 Feb; 128(2):196-205. PMID: 17157356.
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    65. Khaidakov M, Siegel ER, Shmookler Reis RJ. Direct repeats in mitochondrial DNA and mammalian lifespan. Mech Ageing Dev. 2006 Oct; 127(10):808-12. PMID: 16956646.
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    66. Shmookler Reis RJ, Kang P, Ayyadevara S. Quantitative trait loci define genes and pathways underlying genetic variation in longevity. Exp Gerontol. 2006 Oct; 41(10):1046-54. PMID: 16919411.
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    67. Ayyadevara S, Dandapat A, Singh SP, Benes H, Zimniak L, Shmookler Reis RJ, Zimniak P. Lifespan extension in hypomorphic daf-2 mutants of Caenorhabditis elegans is partially mediated by glutathione transferase CeGSTP2-2. Aging Cell. 2005 Dec; 4(6):299-307. PMID: 16300482.
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    68. Ayyadevara S, Engle MR, Singh SP, Dandapat A, Lichti CF, Benes H, Shmookler Reis RJ, Liebau E, Zimniak P. Lifespan and stress resistance of Caenorhabditis elegans are increased by expression of glutathione transferases capable of metabolizing the lipid peroxidation product 4-hydroxynonenal. Aging Cell. 2005 Oct; 4(5):257-71. PMID: 16164425.
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    69. Parsons CA, Mroczkowski HJ, McGuigan FE, Albagha OM, Manolagas S, Reid DM, Ralston SH, Shmookler Reis RJ. Interspecies synteny mapping identifies a quantitative trait locus for bone mineral density on human chromosome Xp22. Hum Mol Genet. 2005 Nov 01; 14(21):3141-8. PMID: 16183656.
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    70. Khaidakov M, Shmookler Reis RJ. Possibility of selection against mtDNA mutations in tumors. Mol Cancer. 2005 Sep 13; 4:36. PMID: 16159390.
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    71. McEwen JE, Zimniak P, Mehta JL, Shmookler Reis RJ. Molecular pathology of aging and its implications for senescent coronary atherosclerosis. Curr Opin Cardiol. 2005 Sep; 20(5):399-406. PMID: 16093759.
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    72. Khaidakov M, Chavannes-Turesky N, Cooney CA, Dupont-Versteegden EE, Kennedy RH, Siegel ER, Khaidakova G, Shmookler Reis RJ. Contribution of de novo point mutations to the overall mutational burden in mitochondrial DNA of adult rats. Exp Gerontol. 2005 May; 40(5):396-402. PMID: 15919591.
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    73. Shammas MA, Liu X, Gavory G, Raney KD, Balasubramanian S, Shmookler Reis RJ. Targeting the single-strand G-rich overhang of telomeres with PNA inhibits cell growth and induces apoptosis of human immortal cells. Exp Cell Res. 2004 Apr 15; 295(1):204-14. PMID: 15051503.
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    74. Shammas MA, Shmookler Reis RJ, Li C, Koley H, Hurley LH, Anderson KC, Munshi NC. Telomerase inhibition and cell growth arrest after telomestatin treatment in multiple myeloma. Clin Cancer Res. 2004 Jan 15; 10(2):770-6. PMID: 14760100.
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    75. Shammas MA, Shmookler Reis RJ, Akiyama M, Koley H, Chauhan D, Hideshima T, Goyal RK, Hurley LH, Anderson KC, Munshi NC. Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in multiple myeloma. Mol Cancer Ther. 2003 Sep; 2(9):825-33. PMID: 14555701.
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    76. Shmookler Reis RJ, Ebert RH. Animal models for discovery and assessment of genetic determinants of osteoporosis. Osteoporos Int. 2003 Sep; 14 Suppl 5:S100-6. PMID: 14504713.
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    77. Shmookler Reis RJ. From QTL mapping to genes: the long and winding road. J Bone Miner Res. 2003 Feb; 18(2):186-9. PMID: 12568394.
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    78. Ayyadevara S, Ayyadevara R, Vertino A, Galecki A, Thaden JJ, Shmookler Reis RJ. Genetic loci modulating fitness and life span in Caenorhabditis elegans: categorical trait interval mapping in CL2a x Bergerac-BO recombinant-inbred worms. Genetics. 2003 Feb; 163(2):557-70. PMID: 12618395.
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    79. Batchu RB, Shammas MA, Wang JY, Shmookler Reis RJ, Munshi NC. Interaction of adeno-associated virus Rep78 with SV40 T antigen: implications in Rep protein expression leading to the inhibition of SV40-mediated cell proliferation. Intervirology. 2002; 45(2):115-8. PMID: 12145545.
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    80. Miller RA, Galecki A, Shmookler-Reis RJ. Interpretation, design, and analysis of gene array expression experiments. J Gerontol A Biol Sci Med Sci. 2001 Feb; 56(2):B52-7. PMID: 11213267.
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    81. Ayyadevara S, Ayyadevara R, Hou S, Thaden JJ, Shmookler Reis RJ. Genetic mapping of quantitative trait loci governing longevity of Caenorhabditis elegans in recombinant-inbred progeny of a Bergerac-BO x RC301 interstrain cross. Genetics. 2001 Feb; 157(2):655-66. PMID: 11156986.
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    82. Batchu RB, Shammas MA, Wang JY, Shmookler Reis RJ, Munshi NC. Expression of AAV Rep proteins in SV40-transformed and untransformed cells: reciprocal interaction with host DNA synthesis. Intervirology. 2001; 44(5):298-305. PMID: 11684891.
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    83. Ayyadevara S, Thaden JJ, Shmookler Reis RJ. Anchor polymerase chain reaction display: a high-throughput method to resolve, score, and isolate dimorphic genetic markers based on interspersed repetitive DNA elements. Anal Biochem. 2000 Aug 15; 284(1):19-28. PMID: 10933851.
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    84. Ayyadevara S, Thaden JJ, Shmookler Reis RJ. Discrimination of primer 3'-nucleotide mismatch by taq DNA polymerase during polymerase chain reaction. Anal Biochem. 2000 Aug 15; 284(1):11-8. PMID: 10933850.
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    85. Cherkasova V, Ayyadevara S, Egilmez N, Shmookler Reis R. Diverse Caenorhabditis elegans genes that are upregulated in dauer larvae also show elevated transcript levels in long-lived, aged, or starved adults. J Mol Biol. 2000 Jul 14; 300(3):433-48. PMID: 10884342.
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    86. Benes H, Weinstein RS, Zheng W, Thaden JJ, Jilka RL, Manolagas SC, Shmookler Reis RJ. Chromosomal mapping of osteopenia-associated quantitative trait loci using closely related mouse strains. J Bone Miner Res. 2000 Apr; 15(4):626-33. PMID: 10780854.
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    87. Thaden JJ, Shmookler Reis RJ. Ammonia, respiration, and longevity in nematodes: insights on metabolic regulation of life span from temporal rescaling. J Am Aging Assoc. 2000 Apr; 23(2):75-84. PMID: 23604841.
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    88. Shammas MA, Simmons CG, Corey DR, Shmookler Reis RJ. Telomerase inhibition by peptide nucleic acids reverses 'immortality' of transformed human cells. Oncogene. 1999 Nov 04; 18(46):6191-200. PMID: 10597217.
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    89. Shammas MA, Shmookler Reis RJ. Recombination and its roles in DNA repair, cellular immortalization and cancer. Age (Omaha). 1999 Apr; 22(2):71-88. PMID: 23604399.
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    90. Li J, Ayyadevera R, Shmookler Reis RJ. Carcinogens stimulate intrachromosomal homologous recombination at an endogenous locus in human diploid fibroblasts. Mutat Res. 1997 Dec; 385(3):173-93. PMID: 9506887.
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    91. Xia SJ, Shammas MA, Shmookler Reis RJ. Elevated recombination in immortal human cells is mediated by HsRAD51 recombinase. Mol Cell Biol. 1997 Dec; 17(12):7151-8. PMID: 9372947.
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    92. Lecka-Czernik B, Moerman EJ, Shmookler Reis RJ, Lipschitz DA. Cellular and molecular biomarkers indicate precocious in vitro senescence in fibroblasts from SAMP6 mice. Evidence supporting a murine model of premature senescence and osteopenia. J Gerontol A Biol Sci Med Sci. 1997 Nov; 52(6):B331-6. PMID: 9402934.
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    93. Cheng RZ, Shammas MA, Li J, Shmookler Reis RJ. Expression of SV40 large T antigen stimulates reversion of a chromosomal gene duplication in human cells. Exp Cell Res. 1997 Aug 01; 234(2):300-12. PMID: 9260898.
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    94. Shammas MA, Xia SJ, Shmookler Reis RJ. Induction of duplication reversion in human fibroblasts, by wild-type and mutated SV40 T antigen, covaries with the ability to induce host DNA synthesis. Genetics. 1997 Aug; 146(4):1417-28. PMID: 9258684.
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    95. van Swinderen B, Shook DR, Ebert RH, Cherkasova VA, Johnson TE, Shmookler Reis RJ, Crowder CM. Quantitative trait loci controlling halothane sensitivity in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 1997 Jul 22; 94(15):8232-7. PMID: 9223344.
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    96. Nikitin AG, Shmookler Reis RJ. Role of transposable elements in age-related genomic instability. Genet Res. 1997 Jun; 69(3):183-95. PMID: 9290321.
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    97. Xia SJ, Shammas MA, Shmookler Reis RJ. Reduced telomere length in ataxia-telangiectasia fibroblasts. Mutat Res. 1996 Sep 02; 364(1):1-11. PMID: 8814333.
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    98. Shmookler Reis RJ, Ebert RH. Genetics of aging: current animal models. Exp Gerontol. 1996 Jan-Apr; 31(1-2):69-81. PMID: 8706806.
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    99. Ebert RH, Shammas MA, Sohal BH, Sohal RS, Egilmez NK, Ruggles S, Shmookler Reis RJ. Defining genes that govern longevity in Caenorhabditis elegans. Dev Genet. 1996; 18(2):131-43. PMID: 8934875.
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    100. Egilmez NK, Ebert RH, Shmookler Reis RJ. Strain evolution in Caenorhabditis elegans: transposable elements as markers of interstrain evolutionary history. J Mol Evol. 1995 Apr; 40(4):372-81. PMID: 7769614.
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    101. Egilmez NK, Shmookler Reis RJ. Age-dependent somatic excision of transposable element Tc1 in Caenorhabditis elegans. Mutat Res. 1994 Feb; 316(1):17-24. PMID: 7507565.
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    102. Ebert RH, Cherkasova VA, Dennis RA, Wu JH, Ruggles S, Perrin TE, Shmookler Reis RJ. Longevity-determining genes in Caenorhabditis elegans: chromosomal mapping of multiple noninteractive loci. Genetics. 1993 Dec; 135(4):1003-10. PMID: 8307318.
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    103. Murano S, Thweatt R, Shmookler Reis RJ, Jones RA, Moerman EJ, Goldstein S. Diverse gene sequences are overexpressed in werner syndrome fibroblasts undergoing premature replicative senescence. Mol Cell Biol. 1991 Aug; 11(8):3905-14. PMID: 1712899.
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    104. Henle KJ, Shmookler Reis RJ, Lumpkin CK. Modulation of cellular glycosidase activity by hyperthermia. Int J Hyperthermia. 1991 May-Jun; 7(3):531-7. PMID: 1833475.
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    105. Thweatt R, Goldstein S, Shmookler Reis RJ. A universal primer mixture for sequence determination at the 3' ends of cDNAs. Anal Biochem. 1990 Nov 01; 190(2):314-6. PMID: 2291476.
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    106. Cheng RZ, Murano S, Kurz B, Shmookler Reis RJ. Homologous recombination is elevated in some Werner-like syndromes but not during normal in vitro or in vivo senescence of mammalian cells. Mutat Res. 1990 Sep-Nov; 237(5-6):259-69. PMID: 2079965.
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    107. Goldstein S, Jones RA, Hardin JW, Braunstein GD, Shmookler Reis RJ. Expression of alpha- and beta-human chorionic gonadotropin subunits in cultured human cells. In Vitro Cell Dev Biol. 1990 Sep; 26(9):857-64. PMID: 1699921.
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    108. Srivastava A, Shmookler Reis RJ, Goldstein S. Absence of reverse transcriptase activity in human diploid fibroblasts. Mech Ageing Dev. 1990 Feb 01; 51(2):133-8. PMID: 1689785.
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    109. Goldstein S, Murano S, Shmookler Reis RJ. Werner syndrome: a molecular genetic hypothesis. J Gerontol. 1990 Jan; 45(1):B3-8. PMID: 2404059.
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    110. Shmookler Reis RJ, Finn GK, Smith K, Goldstein S. Clonal variation in gene methylation: c-H-ras and alpha-hCG regions vary independently in human fibroblast lineages. Mutat Res. 1990 Jan; 237(1):45-57. PMID: 2157149.
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    111. Houde M, Shmookler Reis RJ, Goldstein S. Proportions of H1 histone subspecies in human fibroblasts shift during density-dependent growth arrest independent of replicative senescence. Exp Cell Res. 1989 Sep; 184(1):256-61. PMID: 2792226.
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    112. Finn GK, Kurz BW, Cheng RZ, Shmookler Reis RJ. Homologous plasmid recombination is elevated in immortally transformed cells. Mol Cell Biol. 1989 Sep; 9(9):4009-17. PMID: 2550810.
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    113. Shmookler Reis RJ. Model systems for aging research: syncretic concepts and diversity of mechanisms. Genome. 1989; 31(1):406-12. PMID: 2687106.
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    114. Goldstein S, Murano S, Benes H, Moerman EJ, Jones RA, Thweatt R, Shmookler Reis RJ, Howard BH. Studies on the molecular-genetic basis of replicative senescence in Werner syndrome and normal fibroblasts. Exp Gerontol. 1989; 24(5-6):461-8. PMID: 2632280.
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    115. Shmookler Reis RJ. Strategies and criteria for the development of molecular biomarkers of senescence. Exp Gerontol. 1988; 23(4-5):271-80. PMID: 3058490.
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    116. Shmookler Reis RJ, Srivastava A, Beranek DT, Goldstein S. Human alphoid family of tandemly repeated DNA. Sequence of cloned tetrameric fragments and analysis of familial divergence. J Mol Biol. 1985 Nov 05; 186(1):31-41. PMID: 3001316.
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    117. Goldstein S, Shmookler Reis RJ. Methylation patterns in the gene for the alpha subunit of chorionic gonadotropin are inherited with variable fidelity in clonal lineages of human fibroblasts. Nucleic Acids Res. 1985 Oct 11; 13(19):7055-65. PMID: 4059053.
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    118. Riabowol K, Shmookler Reis RJ, Goldstein S. Interspersed repetitive and tandemly repetitive sequences are differentially represented in extrachromosomal covalently closed circular DNA of human diploid fibroblasts. Nucleic Acids Res. 1985 Aug 12; 13(15):5563-84. PMID: 2994003.
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    119. Shmookler Reis RJ, Lumpkin CK, McGill JR, Riabowol KT, Goldstein S. Amplification of inter-Alu extrachromosomal DNA during cellular ageing: retraction and explanation. Nature. 1985 Jul 11-17; 316(6024):167. PMID: 2989713.
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    120. Srivastava A, Norris JS, Shmookler Reis RJ, Goldstein S. c-Ha-ras-1 proto-oncogene amplification and overexpression during the limited replicative life span of normal human fibroblasts. J Biol Chem. 1985 May 25; 260(10):6404-9. PMID: 3997829.
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    121. Goldstein S, Srivastava A, Riabowol KT, Shmookler Reis RJ. Changes in genetic organization and expression in aging cells. Basic Life Sci. 1985; 35:255-67. PMID: 4062813.
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    122. Lumpkin CK, McGill JR, Riabowol KT, Moerman EJ, Shmookler Reis RJ, Goldstein S. Extrachromosomal circular DNA and aging cells. Adv Exp Med Biol. 1985; 190:479-93. PMID: 3002151.
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    123. Shmookler Reis RJ, Goldstein S. Mitochondrial DNA in mortal and immortal human cells. Genome number, integrity, and methylation. J Biol Chem. 1983 Aug 10; 258(15):9078-85. PMID: 6307991.
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    124. Shmookler Reis RJ, Lumpkin CK, McGill JR, Riabowol KT, Goldstein S. Extrachromosomal circular copies of an 'inter-Alu' unstable sequence in human DNA are amplified during in vitro and in vivo ageing. Nature. 1983 Feb 03; 301(5899):394-8. PMID: 6823315.
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    125. Shmookler Reis RJ, Goldstein S. Interclonal variation in methylation patterns for expressed and non-expressed genes. Nucleic Acids Res. 1982 Jul 24; 10(14):4293-304. PMID: 6896910.
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    126. Shmookler Reis RJ, Goldstein S. Variability of DNA methylation patterns during serial passage of human diploid fibroblasts. Proc Natl Acad Sci U S A. 1982 Jul; 79(13):3949-53. PMID: 6287455.
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    127. Harley CB, Shmookler Reis RJ, Goldstein S. Loss of repetitious DNA in proliferating somatic cells may be due to unequal recombination. J Theor Biol. 1982 Jan 07; 94(1):1-12. PMID: 7078201.
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    128. Shmookler Reis RJ. Ribosomes from aging mice are not generally deficient in cell-free protein synthesis. Mech Ageing Dev. 1981 Dec; 17(4):311-20. PMID: 7329100.
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