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Sung Rhee

TitleAssociate Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPharmacology & Toxicology, College of Medicine
DivisionPharmacology ION Channels
AddressB323G Biomedical Research I
325 S. Elm St.
Mail Slot # 638
Little Rock AR 72205
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    Collapse Research Funds 
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    19TPA34880019     (RHEE, SUNG)Jul 1, 2019 - Jun 30, 2022
    American Heart Association
    Impaired cerebral collateral dilation in hypertension: implications for stroke damage and antihypertensive therapy
    Role: Principal Investigator

    R01HL146713     (MU, SHENGYU)Apr 1, 2019 - Mar 31, 2024
    NIH/Nat. Heart, Lung & Blood Institute
    T cell homing to the kidney contributes to salt retention and blood pressure regulation
    Role: Co-Investigator

    17GRNT33670970     (RHEE, SUNG)Jul 1, 2017 - Jun 30, 2019
    American Heart Association
    Beta adrenergic receptor-mediated vasodilation of cerebral collateral arteries- Resubmission- Resubmission
    Role: Principal Investigator

    S10OD018065     (STORRIE, BRIAN)Jul 1, 2015 - Jun 30, 2016
    Super-Resolution Light Microscope at University of Arkansas for Medical Sciences
    Role: Co-Investigator

    R01HL097107     (RHEE, SUNG W)Mar 15, 2010 - Feb 28, 2015
    PSD95 scaffolding of vascular K+ channels in hypertension
    Role: Principal Investigator

    R01HL095846     (PALADE, PHILIP T.)Jan 22, 2010 - Nov 30, 2014
    MicroRNA to decrease vascular CaV1.2 in hypertension
    Role: Co-Investigator

    R01NS058503     (ZHENG, FANG)Jul 16, 2009 - Jun 30, 2013
    Canonical Transient Receptor Potential Channels and Excitotoxicity
    Role: Co-Investigator

    R01HL064806     (RUSCH, NANCY J)Jun 1, 2009 - Oct 31, 2009
    Vascular Calcium Channel Expression in Hypertension
    Role: Co-Investigator

    R01HL093526     (RUSCH, NANCY J)May 5, 2009 - Apr 30, 2014
    Long-term Antihypertensive Therapy by Delivery of the BK Channel Gene to VSMCs
    Role: Co-Investigator

    0830060N     (RHEE, SUNG)Jan 1, 2008 - Dec 31, 2011
    American Heart Association
    AAV-mediated transduction of BK channel
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Moore CL, Henry DS, McClenahan SJ, Ball KK, Rusch NJ, Rhee SW. Metoprolol Impairs Beta1 Adrenergic Receptor-Mediated Vasodilation in Rat Cerebral Arteries: Implications for Beta-Blocker Therapy. J Pharmacol Exp Ther. 2020 Oct 25. PMID: 33100271.
      View in: PubMed
    2. Henry DS, Wessinger WD, Meena NK, Payakachat N, Gardner JM, Rhee SW. Using a Facebook group to facilitate faculty-student interactions during preclinical medical education: a retrospective survey analysis. BMC Med Educ. 2020 Mar 24; 20(1):87. PMID: 32209076.
      View in: PubMed
    3. Kim JG, Gwak JH, Jung MY, An SU, Hyun JH, Kang S, Rhee SK. Distinct temporal dynamics of planktonic archaeal and bacterial assemblages in the bays of the Yellow Sea. PLoS One. 2019; 14(8):e0221408. PMID: 31449563.
      View in: PubMed
    4. Stolarz AJ, Sarimollaoglu M, Marecki JC, Fletcher TW, Galanzha EI, Rhee SW, Zharov VP, Klimberg VS, Rusch NJ. Doxorubicin Activates Ryanodine Receptors in Rat Lymphatic Muscle Cells to Attenuate Rhythmic Contractions and Lymph Flow. J Pharmacol Exp Ther. 2019 11; 371(2):278-289. PMID: 31439806.
      View in: PubMed
    5. Yi SJ, Hwang SY, Oh MJ, Kim YH, Ryu H, Rhee SK, Jhun BH, Kim K. Oncogenic N-Ras Stimulates SRF-Mediated Transactivation via H3 Acetylation at Lysine 9. Biomed Res Int. 2018; 2018:5473725. PMID: 29511684.
      View in: PubMed
    6. Rhee SW, Rusch NJ. Molecular determinants of beta-adrenergic signaling to voltage-gated K+ channels in the cerebral circulation. Microcirculation. 2018 01; 25(1). PMID: 29072364.
      View in: PubMed
    7. Liu Y, Rafferty TM, Rhee SW, Webber JS, Song L, Ko B, Hoover RS, He B, Mu S. CD8+ T cells stimulate Na-Cl co-transporter NCC in distal convoluted tubules leading to salt-sensitive hypertension. Nat Commun. 2017 01 09; 8:14037. PMID: 28067240.
      View in: PubMed
    8. Detweiler ND, Song L, McClenahan SJ, Versluis RJ, Kharade SV, Kurten RC, Rhee SW, Rusch NJ. BK channels in rat and human pulmonary smooth muscle cells are BKa-ß1 functional complexes lacking the oxygen-sensitive stress axis regulated exon insert. Pulm Circ. 2016 Dec; 6(4):563-575. PMID: 28090300.
      View in: PubMed
    9. Stimers JR, Song L, Rusch NJ, Rhee SW. Overexpression of the Large-Conductance, Ca2+-Activated K+ (BK) Channel Shortens Action Potential Duration in HL-1 Cardiomyocytes. PLoS One. 2015; 10(6):e0130588. PMID: 26091273.
      View in: PubMed
    10. Moore CL, McClenahan SJ, Hanvey HM, Jang DS, Nelson PL, Joseph BK, Rhee SW. Beta1-adrenergic receptor-mediated dilation of rat cerebral artery requires Shaker-type KV1 channels on PSD95 scaffold. J Cereb Blood Flow Metab. 2015 Sep; 35(9):1537-46. PMID: 25966954.
      View in: PubMed
    11. Park SJ, Ghai R, Martín-Cuadrado AB, Rodríguez-Valera F, Chung WH, Kwon K, Lee JH, Madsen EL, Rhee SK. Genomes of two new ammonia-oxidizing archaea enriched from deep marine sediments. PLoS One. 2014; 9(5):e96449. PMID: 24798206.
      View in: PubMed
    12. Moore CL, Nelson PL, Parelkar NK, Rusch NJ, Rhee SW. Protein kinase A-phosphorylated KV1 channels in PSD95 signaling complex contribute to the resting membrane potential and diameter of cerebral arteries. Circ Res. 2014 Apr 11; 114(8):1258-67. PMID: 24585759.
      View in: PubMed
    13. Moore CL, Nelson PL, Chandrika BB, Rhee, S.W. KV1 channel-mediated dilation to isoproterenol in cerebral arteries is disrupted in angiotensin II-induced hypertension. FASEB J. 2013; 27:877.6.
    14. Rhee SW, Song L, Steephan M, Rusch NJ, Stimers JR. Overexpression of the large-conductance, Ca2+-activated K+ (BK) channel shortens action potential duration in HL-1 cardiomyocytes. FASEB J. 2013; 27:879.4.
    15. Detweiler ND, Kharade SV, Versluis RJ, Rhee SW, Rusch NJ, Crooks PA. Targeting the high-conductance Ca2+-activated K+ (BK) channel as vasodilator therapy for pulmonary hypertension. FASEB J. 2013; 27:877.10.
    16. Srivastava AK, Kharade SV, Fletcher TW, Rhee, S.W., Rusch NJ. Alpha1-adrenergic receptor activation rapidly upregulates L-type Ca2+ channels in rat mesenteric arteries in vivo. FASEB J. 2013; 27:1092.3.
    17. Joseph BK, Thakali KM, Moore CL, Rhee, S.W. Ion channel remodeling in vascular smooth muscle during hypertension: Implications for novel therapeutic approaches. Pharmacol Res. 2013; 70(1):126-38 (PMID: 23376354).
    18. Kharad SV, Sonkusare SK, Srivastava A, Thakali KM, Fletcher TW, Rhee, S.W., Rusch NJ. The Beta 3 subunit contributes to vascular calcium channel upregulation and hypertension in angiotensin II-infused C57BL/6 mice. Hypertension. 2013; 61(1):137-142 (PMID: 23129698).
    19. Moore CL, Nelson PL, Parelkar NK, Rusch NJ, Rhee, S.W. PSD95 scaffolding of the Shaker-type K+ channel enables PKA-dependent phosphorylation and vasodilation of cerebral arteries. Circ Res. 2013.
    20. Phelan KD, Shwe UT, Abramowitz J, Wu H, Rhee SW, Howell MD, Gottschall PE, Freichel M, Flockerzi V, Birnbaumer L, Zheng F. Canonical transient receptor channel 5 (TRPC5) and TRPC1/4 contribute to seizure and excitotoxicity by distinct cellular mechanisms. Mol Pharmacol. 2013 Feb; 83(2):429-38. PMID: 23188715.
      View in: PubMed
    21. Kharade SV, Sonkusare SK, Srivastava AK, Thakali KM, Fletcher TW, Rhee SW, Rusch NJ. The ß3 subunit contributes to vascular calcium channel upregulation and hypertension in angiotensin II-infused C57BL/6 mice. Hypertension. 2013 Jan; 61(1):137-42. PMID: 23129698.
      View in: PubMed
    22. Moore CL, Jang DS, Parelkar NK, Joseph BK, Nelson PL, Kang E, Rhee SW. Postsynaptic density-95 (PSD95) mediates vasodilator signaling between {beta}1 adrenergic receptor and Shaker-type K+ (KV1) channel in rat cerebral arteries. FASEB J. 2012; 26:842.6.
    23. Srivastava AK, Kharade SV, Fletcher TW, Rhee, S., Rusch NJ. Dynamic turnover of L-type calcium channels in rat mesenteric arteries in vivo. FASEB J. 2012; 26:1115.16.
    24. Joseph BK, Thakali KM, Pathan AR, Rusch NR, Rhee, S.W. Postsynaptic density-95 (PSD95) scaffolding of Shaker-type K+ channels in smooth muscle cells regulates the diameter of cerebral arteries. J Physiol. 2011; 589((Pt 21)):5143-52 (PMID: 21911612).
    25. Joseph BK, Thakali KM, Pathan AR, Kang E, Rusch NJ, Rhee SW. Postsynaptic density-95 scaffolding of Shaker-type K? channels in smooth muscle cells regulates the diameter of cerebral arteries. J Physiol. 2011 Nov 01; 589(Pt 21):5143-52. PMID: 21911612.
      View in: PubMed
    26. Seely KA, Holthoff JH, Burns ST, Wang Z, Thakali KM, Gokden N, Rhee SW, Mayeux PR. Hemodynamic changes in the kidney in a pediatric rat model of sepsis-induced acute kidney injury. Am J Physiol Renal Physiol. 2011 Jul; 301(1):F209-17. PMID: 21511700.
      View in: PubMed
    27. Joseph BK, Pathan AR, Thakali KM, Kang E, Parelkar NK, Rusch NJ, Rhee SW. Postsynaptic density 95 (PSD95) scaffolding of Shaker-type potassium channels in smooth muscle cells regulates the diameter of rat cerebral arteries. FASEB J. 2011; 25:1081.9.
    28. Kharade SV, Sonkusare SK, Srivastava AK, Thakali KM, Fletcher TW, Rhee SW, Rusch NJ. Upregulation of vascular L-type calcium channels during hypertension is blunted in the absence of accessory ß3 subunits. FASEB J. 2011; 25:808.6.
    29. Wang W, Rhee SW, Chen C, Metha JL, Palade PL. Upregulation of CaV1.2 expression in atherosclerosis. J Am Coll Cardiol. 2010; 55:A166.E1561.
    30. Joseph BK, Rusch NJ, Rhee SW. PSD 95 scaffolds associated with vascular KV1 channels are post-transcriptionally down-regulated in cerebral arteries during hypertension. FASEB J. 2010; 24:576.3.
    31. Wang W, Rhee SW, Mehta JL, Palade P. Vascular CaV1.2 expression is increased in atherosclerosis. Biophys J. 2010; 98:695a.
    32. Thakali KM, Kharade SV, Rhee SW, Rusch NJ. L-type Ca2+ (CaL) channels are silent during depolarization of venous smooth muscle cells. FASEB J. 2010; 24:576.1.
    33. Thakali KM, Kharade SV, Sonkusare SK, Rhee SW, Stimers JR, Rusch NJ. Intracellular Ca2+ silences L-type Ca2+ channels in mesenteric veins: mechanism of venous smooth muscle resistance to calcium channel blockers. Circ Res. 2010 Mar 05; 106(4):739-47. PMID: 20044515.
      View in: PubMed
    34. Rhee SW, Stimers JR, Wang W, Pang L. Vascular smooth muscle-specific knockdown of the noncardiac form of the L-type calcium channel by microRNA-based short hairpin RNA as a potential antihypertensive therapy. J Pharmacol Exp Ther. 2009 May; 329(2):775-82. PMID: 19244098.
      View in: PubMed
    35. Kharade S.V., Sonkusare S., Rusch N.J., Rhee, S.W. Vascular alpha1C and beta3 subunits of L-type calcium channels are coordinately upregulated in the mesenteric artiers of hypertensive C57BL6 mice. FASEB J. 2009; 23:579.11.
    36. Rhee S.W., Stimers J.R., Wang W, Pang L. Vascular smooth muscle specific knockdown of non-cardiac form of L-type calcium channel by shRNA as a potential anti-hypertensive therapy. J Pharmacol Exp Ther. 2009; 329(2):775-82 (PMID: 19244098).
    37. Joseph B.K., Rusch N.J., Rhee, S.W. Beta1 adrenergic receptor-initiated dilation in rat cerebral arteries is mediated by Shaker type KV1 channels and is attenuated in angiotensin II-induced hypertension. FASEB J. 2009; 23:932.14.
    38. Télémaque S, Sonkusare S, Grain T, Rhee SW, Stimers JR, Rusch NJ, Marsh JD. Design of mutant beta2 subunits as decoy molecules to reduce the expression of functional Ca2+ channels in cardiac cells. J Pharmacol Exp Ther. 2008 Apr; 325(1):37-46. PMID: 18184831.
      View in: PubMed
    39. Marsh JD, Telemaque S, Rhee SW, Stimers JR, Rusch NJ. Delivery of ion channel genes to treat cardiovascular diseases. Trans Am Clin Climatol Assoc. 2008; 119:171-82; discussion 182-3. PMID: 18596857.
      View in: PubMed
    40. Pang L., Stimers J., Rhee S, Palade P. Smooth muscle specific knockdown of L-type calcium channel by exogenous microRNA (miRNA). FASEB J. 2008; 22:912.32.
    41. Rhee, S.W, Thakali K., Melchert, R. B, Pang L., Fletcher T.W., Roberto K.A., Hermonat P.L., Rusch N.J. AAV Delivery of the BK Channel Gene to Vascular Smooth Muscle as a Long-lasting Antihypertensive Strategy. Biophys J. 2008; 94:3029.
    42. Joseph B.K., Rhee, S.W, Thakali K., Rusch N.J. Shaker Kv1 channel-MAGUK complexes are down-regulated in cerebral arteries of hypertensive rats. FASEB J. 2008; 22:913.8.
    43. Rhee S. Accessory ß3 subunits promote the functional expression of voltage-gated calcium channels in vascular smooth muscle cells. FASEB J. 2008; 22:912.35.
    44. Telemaque S, Sonkusare S, Grain T, Rhee, S.W, Stimers J.R., Rusch N.J., Marsh J.D. Design of mutant beta subunits as decoy molecules to reduce the expression of functional Ca2+ channels in cardiac cells. J Pharmacol Exp Ther. 2008; 325(1):37-46 (PMID: 18184831).
    45. Joseph B.K., Rhee, S.W, Pesic M, Rusch N.J. Evidence for modulation of Shaker-type (Kv1) channels in rat small cerebral arteries by ancillary Kvß2 subunits. FASEB J. 2007; 21:874.5.
    46. Joseph B.K., Rhee, S.W, Hirenallur D.K., Rusch N.J. Potassium channels in vascular smooth muscle: Structure, function and experimental interventions. 2007.
    47. Hirenallur D.K., Rusch N.J., Liu Y, Hermonat P.L., Zhang D, England S.K., Rhee, S.W. AAV transduction of the MaxiK channel gene in vascular smooth muscle cells for the long-term control of hypertension. FASEB J. 2007; 21:874.4.
    48. Jiang S, Rhee SW, Gleeson PA, Storrie B. Capacity of the Golgi apparatus for cargo transport prior to complete assembly. Mol Biol Cell. 2006 Sep; 17(9):4105-17. PMID: 16837554.
      View in: PubMed
    49. Rhee SW, Starr T, Forsten-Williams K, Storrie B. The steady-state distribution of glycosyltransferases between the Golgi apparatus and the endoplasmic reticulum is approximately 90:10. Traffic. 2005 Nov; 6(11):978-90. PMID: 16190979.
      View in: PubMed
    50. Kang H, Kim H.J., Jo J, Choi M.Y., Rhee, S.W, Koh D.S. Glucose metabolism and oscillatory behavior of pancreatic islets. Phys Rev. 2005; E 72(051905):(PMID: 16383643).
    51. Häggblom MM, Ahn YB, Fennell DE, Kerkhof LJ, Rhee SK. Anaerobic dehalogenation of organohalide contaminants in the marine environment. Adv Appl Microbiol. 2003; 53:61-84. PMID: 14696316.
      View in: PubMed
    52. Jeon G.S., Yin L., Rhee, S.W, Thouless D.J. Pairing instability of mechanical collapse of a Bose gas with an attractive interaction. Phys Rev. 2002; A 66(011603).
    53. Thouless D.J., Geller M.R., Vinen W.F., Fortin J.Y., Rhee, S.W. Vortex dynamics in the two-fluid model. Phys Rev. 2001; B 63(224504).
    54. Choi M.Y., Rhee, S.W, Lee M., Choi J. Renormalization-group study of gate charge effects in Josephson-junction chains. Phys Rev. 2001; B 63(094516).
    55. Geller M.R., Thouless D.J., Rhee, S.W, Vinen W.F. Iordanskii and Lifshitz-Pitaevskii forces in the two fluid model. J Low Temp Phys. 2000; 121:411-416.
    56. Park K., Rhee, S.W, Choi M.Y. Glass synchronization in the network of oscillators with random phase shifts. Phys Rev. 1998; E 57:5030-5035.
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