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Mark Smeltzer

TitleProfessor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentMicrobiology & Immunology, College of Medicine
DivisionMicrobiology & Immunology Mole Stp
Address519-2 Biomedical Research II
200 South Cedar
Mail Slot # 511
Little Rock AR 72202
Phone501-686-7958
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    Other Positions
    TitleProfessor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentOrthopaedics, College of Medicine

    TitleProfessor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentPathology, College of Medicine


    Collapse Research Funds 
    Collapse principal investigator
    Pass Through Agency: University of Memphis - Funding Agency: DHHS - Biomedical Advanced Research and Development Authority - Title: Investigating a Flexible, Degradable Local Antimicrobial Delivery System - Award Number: 5 R01 AR066050-02 - Start Date: 2016-01-01

    Pass Through Agency: University of Memphis - Funding Agency: DHHS - Biomedical Advanced Research and Development Authority - Title: Investigating a Flexible, Degradable Local Antimicrobial Delivery System - Award Number: R01 AR066050 - Start Date: 2016-01-01

    Funding Agency: US Department of Defense - Title: Enhancing the prevention and treatment of orthopaedic infections associated with traumatic injury - Award Number: W81XWH-15-1-0716 - Start Date: 2015-09-30

    Funding Agency: NIH/Nat. Cancer Institute - Title: Impact of Staphylococcus aureus in osteomyelitis and bone physiology - Award Number: 1 R01 AI119380-01 - Start Date: 2015-06-15

    Funding Agency: NIH/Nat. Cancer Institute - Title: Impact of Staphylococcus aureus in osteomyelitis and bone physiology - Award Number: 5 R01 AI119380-02 - Start Date: 2015-06-15

    Funding Agency: NIH/Nat. Cancer Institute - Title: Impact of Staphylococcus aureus in osteomyelitis and bone physiology - Award Number: 5 R01 AI119380-03 - Start Date: 2015-06-15

    Funding Agency: NIH/Nat. Cancer Institute - Title: Impact of Staphylococcus aureus in osteomyelitis and bone physiology - Award Number: 5 R01 AI119380-04 - Start Date: 2015-06-15

    Funding Agency: NIH/Nat. Cancer Institute - Title: Impact of Staphylococcus aureus in osteomyelitis and bone physiology - Award Number: 5 R01 AI119380-05 - Start Date: 2015-06-15

    Funding Agency: NIH/Nat. Cancer Institute - Title: Impact of Staphylococcus aureus in osteomyelitis and bone physiology - Award Number: 1 R01 AI119380-01 - Total direct costs: $1,250,000 - Start Date: 2015-06-15

    Pass Through Agency: University of Memphis - Funding Agency: Biomet Manufacturing, LLC - Title: INfection Prevention Through Implant Coating - Award Number: S-2555 - Total direct costs: $16,949 - Start Date: 2014-04-01

    Pass Through Agency: University of Memphis - Funding Agency: US Department of Defense - Title: Antibiotic-Loaded Biopolymer Sponge for Prevention of Polymicrobial Wound Infection - Award Number: W81XWH-12-2-002 - Start Date: 2014-03-01

    Pass Through Agency: University of Memphis - Funding Agency: US Department of Defense - Title: Antibiotic-Loaded Biopolymer Sponge for Prevention of Polymicrobial Wound Infection - Award Number: W81XWH-12-2-002 - Total direct costs: $101,691 - Start Date: 2014-03-01

    Pass Through Agency: University of Southern Mississippi - Funding Agency: NIH/Nat. Inst. of Allergy & Infectious Diseases - Title: Biofilm Dissemination in Staphylococcus aureus - Award Number: 1 R15 AI099922-01A1 - Start Date: 2013-01-01

    Pass Through Agency: University of Southern Mississippi - Funding Agency: NIH/Nat. Inst. of Allergy & Infectious Diseases - Title: Biofilm Dissemination in Staphylococcus aureus - Award Number: 1 R15 AI099922-01A1 - Total direct costs: $20,000 - Start Date: 2013-01-01

    Funding Agency: NIH/Nat. Inst. of General Medical Sciences - Title: Microbial Pathogenesisi and Host Inflammatory Responses - Award Number: 2 P20 GM103625-06 - Start Date: 2012-08-15

    Funding Agency: NIH/Nat. Inst. of General Medical Sciences - Title: Microbial Pathogenesisi and Host Inflammatory Responses - Award Number: 4 P20 GM103625-05 - Start Date: 2012-08-15

    Funding Agency: NIH/Nat. Inst. of General Medical Sciences - Title: Microbial Pathogenesisi and Host Inflammatory Responses - Award Number: 5 P20 GM103625-04 - Start Date: 2012-08-15

    Funding Agency: NIH/Nat. Inst. of General Medical Sciences - Title: Microbial Pathogenesisi and Host Inflammatory Responses - Award Number: P20GM103625 - Start Date: 2012-08-15

    Funding Agency: NIH/Nat. Inst. of General Medical Sciences - Title: Microbial Pathogenesis and Host Inflammatory Responses - Award Number: 1 P20 GM103625-01 - Total direct costs: $5,910,540 - Start Date: 2012-08-15

    Funding Agency: NIH/Nat. Inst. of General Medical Sciences - Title: Microbial Pathogenesisi and Host Inflammatory Responses - Award Number: 5 P20 GM103625-04 - Total direct costs: $2,744,560 - Start Date: 2012-08-15

    Pass Through Agency: University of Memphis - Funding Agency: US Department of Defense - Title: Antibiotic-Loaded Biopolymer Sponge for Prevention of Polymicrobial Wound Infection - Award Number: W81XWH-12-2-0020 - Total direct costs: $212,335 - Start Date: 2012-04-01


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Harris MA, Beenken KE, Smeltzer MS, Haggard WO, Jennings JA. Phosphatidylcholine Coatings Deliver Local Antimicrobials and Reduce Infection in a Murine Model: A Preliminary Study. Clin Orthop Relat Res. 2017 Jul; 475(7):1847-1853. PMID: 28050817.
      View in: PubMed
    2. Berretta JM, Jennings JA, Courtney HS, Beenken KE, Smeltzer MS, Haggard WO. Blended Chitosan Paste for Infection Prevention: Preliminary and Preclinical Evaluations. Clin Orthop Relat Res. 2017 Jul; 475(7):1857-1870. PMID: 28097503.
      View in: PubMed
    3. Rhodes CS, Alexander CM, Berretta JM, Courtney HS, Beenken KE, Smeltzer MS, Bumgardner JD, Haggard WO, Jennings JA. Evaluation of a chitosan-polyethylene glycol paste as a local antibiotic delivery device. World J Orthop. 2017 Feb 18; 8(2):130-141. PMID: 28251063.
      View in: PubMed
    4. Meeker DG, Beenken KE, Mills WB, Loughran AJ, Spencer HJ, Lynn WB, Smeltzer MS. Evaluation of Antibiotics Active against Methicillin-Resistant Staphylococcus aureus Based on Activity in an Established Biofilm. Antimicrob Agents Chemother. 2016 Oct; 60(10):5688-94. PMID: 27401574.
      View in: PubMed
    5. Loughran AJ, Gaddy D, Beenken KE, Meeker DG, Morello R, Zhao H, Byrum SD, Tackett AJ, Cassat JE, Smeltzer MS. Impact of sarA and Phenol-Soluble Modulins on the Pathogenesis of Osteomyelitis in Diverse Clinical Isolates of Staphylococcus aureus. Infect Immun. 2016 Sep; 84(9):2586-94. PMID: 27354444; PMCID: PMC4995912 [Available on 02/19/17].
    6. Jennings JA, Beenken KE, Skinner RA, Meeker DG, Smeltzer MS, Haggard WO, Troxel KS. Antibiotic-loaded phosphatidylcholine inhibits staphylococcal bone infection. World J Orthop. 2016 Aug 18; 7(8):467-74. PMID: 27622146; PMCID: PMC4990767.
    7. Meeker DG, Chen J, Smeltzer MS. Could targeted, antibiotic-loaded gold nanoconstructs be a new magic bullet to fight infection? Nanomedicine (Lond). 2016 Sep; 11(18):2379-82. PMID: 27529572.
      View in: PubMed
    8. Smeltzer MS. Staphylococcus aureus Pathogenesis: The Importance of Reduced Cytotoxicity. Trends Microbiol. 2016 Sep; 24(9):681-2. PMID: 27450110.
      View in: PubMed
    9. Ordóñez PE, Quave CL, Reynolds WF, Varughese KI, Berry B, Breen PJ, Malagón O, Vidari G, Smeltzer MS, Compadre CM. Corrigendum to "Sesquiterpene lactones from Gynoxys verrucosa and their anti-MRSA activity" [J. Ethnopharmacol. 137 (2011) 1055-1059]. J Ethnopharmacol. 2016 Jun 20; 186:392. PMID: 27165010.
      View in: PubMed
    10. Atwood DN, Beenken KE, Loughran AJ, Meeker DG, Lantz TL, Graham JW, Spencer HJ, Smeltzer MS. XerC Contributes to Diverse Forms of Staphylococcus aureus Infection via agr-Dependent and agr-Independent Pathways. Infect Immun. 2016 Apr; 84(4):1214-25. PMID: 26857575; PMCID: PMC4807471.
    11. Meeker DG, Jenkins SV, Miller EK, Beenken KE, Loughran AJ, Powless A, Muldoon TJ, Galanzha EI, Zharov VP, Smeltzer MS, Chen J. Synergistic Photothermal and Antibiotic Killing of Biofilm-Associated Staphylococcus aureus Using Targeted Antibiotic-Loaded Gold Nanoconstructs. ACS Infect Dis. 2016 Apr 08; 2(4):241-250. PMID: 27441208.
      View in: PubMed
    12. Jennings JA, Beenken KE, Parker AC, Smith JK, Courtney HS, Smeltzer MS, Haggard WO. Polymicrobial Biofilm Inhibition Effects of Acetate-Buffered Chitosan Sponge Delivery Device. Macromol Biosci. 2016 Apr; 16(4):591-8. PMID: 26756211.
      View in: PubMed
    13. Atwood DN, Beenken KE, Lantz TL, Meeker DG, Lynn WB, Mills WB, Spencer HJ, Smeltzer MS. Regulatory Mutations Impacting Antibiotic Susceptibility in an Established Staphylococcus aureus Biofilm. Antimicrob Agents Chemother. 2016 Jan 11; 60(3):1826-9. PMID: 26824954; PMCID: PMC4775981.
    14. Albayati ZA, Sunkara M, Schmidt-Malan SM, Karau MJ, Morris AJ, Steckelberg JM, Patel R, Breen PJ, Smeltzer MS, Taylor KG, Merten KE, Pierce WM, Crooks PA. Novel Bone-Targeting Agent for Enhanced Delivery of Vancomycin to Bone. Antimicrob Agents Chemother. 2015 Dec 14; 60(3):1865-8. PMID: 26666918; PMCID: PMC4776008.
    15. Jennings JA, Carpenter DP, Troxel KS, Beenken KE, Smeltzer MS, Courtney HS, Haggard WO. Novel Antibiotic-loaded Point-of-care Implant Coating Inhibits Biofilm. Clin Orthop Relat Res. 2015 Jul; 473(7):2270-82. PMID: 25604874; PMCID: PMC4457766.
    16. Cue D, Junecko JM, Lei MG, Blevins JS, Smeltzer MS, Lee CY. SaeRS-dependent inhibition of biofilm formation in Staphylococcus aureus Newman. PLoS One. 2015; 10(4):e0123027. PMID: 25853849; PMCID: PMC4390220.
    17. Atwood DN, Loughran AJ, Courtney AP, Anthony AC, Meeker DG, Spencer HJ, Gupta RK, Lee CY, Beenken KE, Smeltzer MS. Comparative impact of diverse regulatory loci on Staphylococcus aureus biofilm formation. Microbiologyopen. 2015 Jun; 4(3):436-51. PMID: 25810138; PMCID: PMC4475386.
    18. Parker AC, Beenken KE, Jennings JA, Hittle L, Shirtliff ME, Bumgardner JD, Smeltzer MS, Haggard WO. Characterization of local delivery with amphotericin B and vancomycin from modified chitosan sponges and functional biofilm prevention evaluation. J Orthop Res. 2015 Mar; 33(3):439-47. PMID: 25408519.
      View in: PubMed
    19. Loughran AJ, Atwood DN, Anthony AC, Harik NS, Spencer HJ, Beenken KE, Smeltzer MS. Impact of individual extracellular proteases on Staphylococcus aureus biofilm formation in diverse clinical isolates and their isogenic sarA mutants. Microbiologyopen. 2014 Dec; 3(6):897-909. PMID: 25257373; PMCID: PMC4263513.
    20. Beenken KE, Smith JK, Skinner RA, Mclaren SG, Bellamy W, Gruenwald MJ, Spencer HJ, Jennings JA, Haggard WO, Smeltzer MS. Chitosan coating to enhance the therapeutic efficacy of calcium sulfate-based antibiotic therapy in the treatment of chronic osteomyelitis. J Biomater Appl. 2014 Oct; 29(4):514-23. PMID: 24854984; PMCID: PMC4264383.
    21. Beenken KE, Mrak LN, Zielinska AK, Atwood DN, Loughran AJ, Griffin LM, Matthews KA, Anthony AM, Spencer HJ, Skinner RA, Post GR, Lee CY, Smeltzer MS. Impact of the functional status of saeRS on in vivo phenotypes of Staphylococcus aureus sarA mutants. Mol Microbiol. 2014 Jun; 92(6):1299-312. PMID: 24779437; PMCID: PMC4084611.
    22. Cassat JE, Smeltzer MS, Lee CY. Investigation of biofilm formation in clinical isolates of Staphylococcus aureus. Methods Mol Biol. 2014; 1085:195-211. PMID: 24085698.
      View in: PubMed
    23. Snowden JN, Beaver M, Beenken K, Smeltzer M, Horswill AR, Kielian T. Staphylococcus aureus sarA regulates inflammation and colonization during central nervous system biofilm formation. PLoS One. 2013; 8(12):e84089. PMID: 24386336; PMCID: PMC3875531.
    24. Cassat JE, Hammer ND, Campbell JP, Benson MA, Perrien DS, Mrak LN, Smeltzer MS, Torres VJ, Skaar EP. A secreted bacterial protease tailors the Staphylococcus aureus virulence repertoire to modulate bone remodeling during osteomyelitis. Cell Host Microbe. 2013 Jun 12; 13(6):759-72. PMID: 23768499; PMCID: PMC3721972.
    25. Nedosekin DA, Juratli MA, Sarimollaoglu M, Moore CL, Rusch NJ, Smeltzer MS, Zharov VP, Galanzha EI. Photoacoustic and photothermal detection of circulating tumor cells, bacteria and nanoparticles in cerebrospinal fluid in vivo and ex vivo. J Biophotonics. 2013 Jun; 6(6-7):523-33. PMID: 23681943; PMCID: PMC3954749.
    26. Hart ME, Tsang LH, Deck J, Daily ST, Jones RC, Liu H, Hu H, Hart MJ, Smeltzer MS. Hyaluronidase expression and biofilm involvement in Staphylococcus aureus UAMS-1 and its sarA, agr and sarA agr regulatory mutants. Microbiology. 2013 Apr; 159(Pt 4):782-91. PMID: 23393148; PMCID: PMC3709827.
    27. Hobby GH, Quave CL, Nelson K, Compadre CM, Beenken KE, Smeltzer MS. Quercus cerris extracts limit Staphylococcus aureus biofilm formation. J Ethnopharmacol. 2012 Dec 18; 144(3):812-5. PMID: 23127649; PMCID: PMC3516361.
    28. Zielinska AK, Beenken KE, Mrak LN, Spencer HJ, Post GR, Skinner RA, Tackett AJ, Horswill AR, Smeltzer MS. sarA-mediated repression of protease production plays a key role in the pathogenesis of Staphylococcus aureus USA300 isolates. Mol Microbiol. 2012 Dec; 86(5):1183-96. PMID: 23075270; PMCID: PMC3508076.
    29. Galanzha EI, Shashkov E, Sarimollaoglu M, Beenken KE, Basnakian AG, Shirtliff ME, Kim JW, Smeltzer MS, Zharov VP. In vivo magnetic enrichment, photoacoustic diagnosis, and photothermal purging of infected blood using multifunctional gold and magnetic nanoparticles. PLoS One. 2012; 7(9):e45557. PMID: 23049814; PMCID: PMC3458934.
    30. Beenken KE, Bradney L, Bellamy W, Skinner RA, McLaren SG, Gruenwald MJ, Spencer HJ, Smith JK, Haggard WO, Smeltzer MS. Use of xylitol to enhance the therapeutic efficacy of polymethylmethacrylate-based antibiotic therapy in treatment of chronic osteomyelitis. Antimicrob Agents Chemother. 2012 Nov; 56(11):5839-44. PMID: 22948866; PMCID: PMC3486578.
    31. Brown TL, Spencer HJ, Beenken KE, Alpe TL, Bartel TB, Bellamy W, Gruenwald JM, Skinner RA, McLaren SG, Smeltzer MS. Evaluation of dynamic [18F]-FDG-PET imaging for the detection of acute post-surgical bone infection. PLoS One. 2012; 7(7):e41863. PMID: 22860021; PMCID: PMC3408436.
    32. Snowden JN, Beaver M, Smeltzer MS, Kielian T. Biofilm-infected intracerebroventricular shunts elicit inflammation within the central nervous system. Infect Immun. 2012 Sep; 80(9):3206-14. PMID: 22753376; PMCID: PMC3418739.
    33. Mrak LN, Zielinska AK, Beenken KE, Mrak IN, Atwood DN, Griffin LM, Lee CY, Smeltzer MS. saeRS and sarA act synergistically to repress protease production and promote biofilm formation in Staphylococcus aureus. PLoS One. 2012; 7(6):e38453. PMID: 22685571; PMCID: PMC3369899.
    34. Morrison JM, Anderson KL, Beenken KE, Smeltzer MS, Dunman PM. The staphylococcal accessory regulator, SarA, is an RNA-binding protein that modulates the mRNA turnover properties of late-exponential and stationary phase Staphylococcus aureus cells. Front Cell Infect Microbiol. 2012; 2:26. PMID: 22919618; PMCID: PMC3417590.
    35. Beenken KE, Spencer H, Griffin LM, Smeltzer MS. Impact of extracellular nuclease production on the biofilm phenotype of Staphylococcus aureus under in vitro and in vivo conditions. Infect Immun. 2012 May; 80(5):1634-8. PMID: 22354028; PMCID: PMC3347440.
    36. Quave CL, Estévez-Carmona M, Compadre CM, Hobby G, Hendrickson H, Beenken KE, Smeltzer MS. Ellagic acid derivatives from Rubus ulmifolius inhibit Staphylococcus aureus biofilm formation and improve response to antibiotics. PLoS One. 2012; 7(1):e28737. PMID: 22242149; PMCID: PMC3252291.
    37. Kiedrowski MR, Kavanaugh JS, Malone CL, Mootz JM, Voyich JM, Smeltzer MS, Bayles KW, Horswill AR. Nuclease modulates biofilm formation in community-associated methicillin-resistant Staphylococcus aureus. PLoS One. 2011; 6(11):e26714. PMID: 22096493; PMCID: PMC3214024.
    38. Ordóñez PE, Quave CL, Reynolds WF, Varughese KI, Berry B, Breen PJ, Malagón O, Smeltzer MS, Compadre CM. Sesquiterpene lactones from Gynoxys verrucosa and their anti-MRSA activity. J Ethnopharmacol. 2011 Sep 02; 137(2):1055-9. PMID: 21782013; PMCID: PMC3159821.
    39. Abel J, Goldmann O, Ziegler C, Höltje C, Smeltzer MS, Cheung AL, Bruhn D, Rohde M, Medina E. Staphylococcus aureus evades the extracellular antimicrobial activity of mast cells by promoting its own uptake. J Innate Immun. 2011; 3(5):495-507. PMID: 21654154.
      View in: PubMed
    40. Gurjala AN, Geringer MR, Seth AK, Hong SJ, Smeltzer MS, Galiano RD, Leung KP, Mustoe TA. Development of a novel, highly quantitative in vivo model for the study of biofilm-impaired cutaneous wound healing. Wound Repair Regen. 2011 May-Jun; 19(3):400-10. PMID: 21518094.
      View in: PubMed
    41. Zielinska AK, Beenken KE, Joo HS, Mrak LN, Griffin LM, Luong TT, Lee CY, Otto M, Shaw LN, Smeltzer MS. Defining the strain-dependent impact of the Staphylococcal accessory regulator (sarA) on the alpha-toxin phenotype of Staphylococcus aureus. J Bacteriol. 2011 Jun; 193(12):2948-58. PMID: 21478342; PMCID: PMC3133183.
    42. Olson PD, Kuechenmeister LJ, Anderson KL, Daily S, Beenken KE, Roux CM, Reniere ML, Lewis TL, Weiss WJ, Pulse M, Nguyen P, Simecka JW, Morrison JM, Sayood K, Asojo OA, Smeltzer MS, Skaar EP, Dunman PM. Small molecule inhibitors of Staphylococcus aureus RnpA alter cellular mRNA turnover, exhibit antimicrobial activity, and attenuate pathogenesis. PLoS Pathog. 2011 Feb 10; 7(2):e1001287. PMID: 21347352; PMCID: PMC3037362.
    43. Zielinska, A, Beenken, K. E., Joo, H-S, Mrak, L, Griffin, L. M, Luong, T. T, Lee, C. Y, Otto, M, Shaw, L. N, Smeltzer, M. S. Stopping the flow of extracellular proteases: The role of sarA in promoting the ability of agr to modulate the phenotype of Staphylococcus aureus clinical isolates. Journal of Bacteriology. 2011; (Submitted).
    44. Quave, C. L, Campadre, C, Hendrickson, H, Beenken, K, Smeltzer, M. S. Antibiotic susceptibility of biofilm-associated Staphylococcus aureus is potential by synergy with elmleaf blackberry extract. Journal of Antimicrobial Chemotherapy. 2011; (Submitted).
    45. Olsen, P. D, Kuechenmeister, L. J, Anderson, K. L, Beenken, K. E, Reniere, M. L, Lewis, T. L, Weiss, W. J, Pulse, M, Nguyen, P, Simecka, J. W, Morrison, J. M, Saygood, K, Asojo, O. A, Smeltzer, M. S, Skaar, E. P, Dunman, P. M. Small molecule inhibitors of Staphylococcus aureus RnpA-mediated RNA degradation exhibit antimicrobial activity and diminish pathogenesis. PLoS Pathogens. 2011; In Press.
    46. Smith JK, Bumgardner JD, Courtney HS, Smeltzer MS, Haggard WO. Antibiotic-loaded chitosan film for infection prevention: A preliminary in vitro characterization. J Biomed Mater Res B Appl Biomater. 2010 Jul; 94(1):203-11. PMID: 20524196; PMCID: PMC4376318.
    47. Beenken KE, Mrak LN, Griffin LM, Zielinska AK, Shaw LN, Rice KC, Horswill AR, Bayles KW, Smeltzer MS. Epistatic relationships between sarA and agr in Staphylococcus aureus biofilm formation. PLoS One. 2010 May 24; 5(5):e10790. PMID: 20520723; PMCID: PMC2875390.
    48. Harik NS, Smeltzer MS. Management of acute hematogenous osteomyelitis in children. Expert Rev Anti Infect Ther. 2010 Feb; 8(2):175-81. PMID: 20109047; PMCID: PMC2836799.
    49. Harik, N.S., Smeltzer M. Management of osteomyelitis in children. Expert Review of Anti-infective Therapy. 2010; (8):175-181.
    50. Fujimoto DF, Higginbotham RH, Sterba KM, Maleki SJ, Segall AM, Smeltzer MS, Hurlburt BK. Staphylococcus aureus SarA is a regulatory protein responsive to redox and pH that can support bacteriophage lambda integrase-mediated excision/recombination. Mol Microbiol. 2009 Dec; 74(6):1445-58. PMID: 19919677; PMCID: PMC2879156.
    51. Weiss EC, Zielinska A, Beenken KE, Spencer HJ, Daily SJ, Smeltzer MS. Impact of sarA on daptomycin susceptibility of Staphylococcus aureus biofilms in vivo. Antimicrob Agents Chemother. 2009 Oct; 53(10):4096-102. PMID: 19651914; PMCID: PMC2764180.
    52. Mann EE, Rice KC, Boles BR, Endres JL, Ranjit D, Chandramohan L, Tsang LH, Smeltzer MS, Horswill AR, Bayles KW. Modulation of eDNA release and degradation affects Staphylococcus aureus biofilm maturation. PLoS One. 2009 Jun 09; 4(6):e5822. PMID: 19513119; PMCID: PMC2688759.
    53. Nagarajan V, Smeltzer MS, Elasri MO. Genome-scale transcriptional profiling in Staphylococcus aureus : bringing order out of chaos. FEMS Microbiol Lett. 2009 Jun; 295(2):204-10. PMID: 19459979; PMCID: PMC2753426.
    54. Weiss EC, Spencer HJ, Daily SJ, Weiss BD, Smeltzer MS. Impact of sarA on antibiotic susceptibility of Staphylococcus aureus in a catheter-associated in vitro model of biofilm formation. Antimicrob Agents Chemother. 2009 Jun; 53(6):2475-82. PMID: 19289527; PMCID: PMC2687244.
    55. Weiss, E.C., Zielinska, A., Beenken, K.E., Spencer, H.J., Daily, S.J., Smeltzer M. Mutation od sarA increases the susceptibility of Staphylococcus aureus biofilms to daptomycin in vivo. Antimicrobial Agents and Chemotheraphy. 2009; 53:4096-4102.
    56. Smeltzer M, C.Y. Lee, N. Harik, M.E. Hart. The molecular basis of pathogenesis, p. X-X. In K. The staphylococcus in human disease. 2009; Pp. 65-108.
    57. Weiss BD, Weiss EC, Haggard WO, McLaren SG, Smeltzer M. Optimized elution of daptomycin from polymethmethacrylate (PMMA) beads. Antimicrob. Agents Chemother. 2009; 53:264-266.
    58. Smeltzer M, Lee CY, Harik N, Hart ME. The Staphylococci in Human Disease. The molecular basis of pathogenicity. 2009.
    59. Smeltzer, M. S, Nelson, C. L, Evans, R. P. Biofilms and aseptic loosening. 2009.
    60. Weiss EC, Spencer HJ, Daily SJ, Weiss BD, Smeltzer M. Mutation of sarA increases the susceptibility of Staphylococcus aureus biofilms to daptomycin in vivo. Antimicrobial Agents and Chemotherapy. 2009; (53):4096-4102.
    61. Weiss, E.C., Spencer, H.J., Daily, S.J., Weiss, B.D., Smeltzer M. Impact of sarA on the antibiotic susceptibility of Staphylococcus aureus in vitro in a catheter-associated biofilm model. Antimicrobial Agents and Chemotheraphy. 2009; 53:2475-2482.
    62. Weiss, B.D., Weiss, E.C., Haggard, W.O., McLaren, S.G., Smeltzer, M. S. Optimized elution of daptomycin from polymethymethacrylate (PMMA) beads. Antimicrobial Agents and Chemotheraphy. 2009; 53:264-266.
    63. Weiss, E. C, Spencer, H. J, Daily, S. J, Weiss, B. D, Smeltzer, M. S. Impact of sarA on the antibiotic susceptibility of Staphylococcus aureus in vitro in a catheter-associated biofilm model. Antimicrobial Agents and Chemotherapy. 2009; (53):2475-2482.
    64. Weiss BD, Weiss EC, Haggard WO, Evans RP, McLaren SG, Smeltzer MS. Optimized elution of daptomycin from polymethylmethacrylate beads. Antimicrob Agents Chemother. 2009 Jan; 53(1):264-6. PMID: 18955530; PMCID: PMC2612151.
    65. Tsang LH, Cassat JE, Shaw LN, Beenken KE, Smeltzer MS. Factors contributing to the biofilm-deficient phenotype of Staphylococcus aureus sarA mutants. PLoS One. 2008; 3(10):e3361. PMID: 18846215; PMCID: PMC2556392.
    66. Zhu Y, Weiss EC, Otto M, Fey PD, Smeltzer MS, Somerville GA. Staphylococcus aureus biofilm metabolism and the influence of arginine on polysaccharide intercellular adhesin synthesis, biofilm formation, and pathogenesis. Infect Immun. 2007 Sep; 75(9):4219-26. PMID: 17576756; PMCID: PMC1951195.
    67. Tsang LH, Daily ST, Weiss EC, Smeltzer MS. Mutation of traP in Staphylococcus aureus has no impact on expression of agr or biofilm formation. Infect Immun. 2007 Sep; 75(9):4528-33. PMID: 17548479; PMCID: PMC1951201.
    68. Rice KC, Mann EE, Endres JL, Weiss EC, Cassat JE, Smeltzer MS, Bayles KW. The cidA murein hydrolase regulator contributes to DNA release and biofilm development in Staphylococcus aureus. Proc Natl Acad Sci U S A. 2007 May 08; 104(19):8113-8. PMID: 17452642; PMCID: PMC1876580.
    69. Cassat JE, Lee CY, Smeltzer MS. Investigation of biofilm formation in clinical isolates of Staphylococcus aureus. Methods Mol Biol. 2007; 391:127-44. PMID: 18025674; PMCID: PMC4098860.
    70. Zhu Y, Weiss EC, Otto M, Fey PD, Smeltzer MS, Somerville GA. Staphylococcus aureus biofilm metabolism and the influence of arginine on polysaccharide intercellular adhedin synthesis, biofilm formation, and pathogenesis. Infection and Immunity. 2007; 75:4219-4226.
    71. Tsang LH, Daily S, Weiss EC, Smeltzer MS. Mutation of traP in clinical isolates of Staphylococcus aureus has not impact on expression of agr or on biofilm formation. Infection and Immunity. 2007; 75:4528-4533.
    72. McLaren AC, McLaren SG, Smeltzer M. Xylitol and glycine fillers increase permeability of PMMA to enhance elution of daptomycin. Clin Orthop Relat Res. 2006 Oct; 451:25-8. PMID: 16906079.
      View in: PubMed
    73. Cassat J, Dunman PM, Murphy E, Projan SJ, Beenken KE, Palm KJ, Yang SJ, Rice KC, Bayles KW, Smeltzer MS. Transcriptional profiling of a Staphylococcus aureus clinical isolate and its isogenic agr and sarA mutants reveals global differences in comparison to the laboratory strain RN6390. Microbiology. 2006 Oct; 152(Pt 10):3075-90. PMID: 17005987.
      View in: PubMed
    74. Sambanthamoorthy K, Smeltzer MS, Elasri MO. Identification and characterization of msa (SA1233), a gene involved in expression of SarA and several virulence factors in Staphylococcus aureus. Microbiology. 2006 Sep; 152(Pt 9):2559-72. PMID: 16946251.
      View in: PubMed
    75. Roberts C, Anderson KL, Murphy E, Projan SJ, Mounts W, Hurlburt B, Smeltzer M, Overbeek R, Disz T, Dunman PM. Characterizing the effect of the Staphylococcus aureus virulence factor regulator, SarA, on log-phase mRNA half-lives. J Bacteriol. 2006 Apr; 188(7):2593-603. PMID: 16547047; PMCID: PMC1428411.
    76. Kanangat S, Postlethwaite A, Hasty K, Kang A, Smeltzer M, Appling W, Schaberg D. Induction of multiple matrix metalloproteinases in human dermal and synovial fibroblasts by Staphylococcus aureus: implications in the pathogenesis of septic arthritis and other soft tissue infections. Arthritis Res Ther. 2006; 8(6):R176. PMID: 17129374; PMCID: PMC1794521.
    77. Sambanthamoorthy K, Smeltzer M, Elasri MO. Identification and characterization of msa (SA1233), a gene that is involved in expression of sarA and several virulence factors in Staphylococcus aureus. Microbiology. 2006; 152:2559-2572.
    78. Kanangat S, Postlehwaite A, Hasty K, Kang A, Smeltzer M, Appling W, Schaberg D. Induction of multiple matrix metalloproteinases in human dermal and synovia fibroblasts by Staphylococcus aureus: Implications in the pathogenesis of septic arthritis and other soft tissue infections. Arthritis Research and Theraphy. 2006.
    79. Cassat JE, Weiss EC, Beenken KE, Yang S-J, Bayles KW, Smeltzer M. Disruption of acetolactate synthase (alsS) and acetolactate decarboxylase (alsD) in Staphylococcus aureus limits biofilm formation in vitro and in vivo. Microbiology. 2006.
    80. Cassat JE, Dunman PM, Murphy EJ, Projan SJ, Beenken KE, Palm KJ, Yang S-J, Rice KC, Bayles KW, Smeltzer MS. Transcriptional profiling of a Staphylococcus aureus clinical isolate and its isogenic agr and sarA mutants reveals global differences by comparison to the laboratory strain RN6390. Microbiology. 2006; 152:3075-3090.
    81. Jones-Jackson L, Walker R, Purnell G, McLaren SG, Skinner RA, Thomas JR, Suva LJ, Anaissie E, Miceli M, Nelson CL, Ferris EJ, Smeltzer MS. Early detection of bone infection and differentiation from post-surgical inflammation using 2-deoxy-2-[18F]-fluoro-D-glucose positron emission tomography (FDG-PET) in an animal model. J Orthop Res. 2005 Nov; 23(6):1484-9. PMID: 15896941.
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    82. Zharov VP, Mercer KE, Galitovskaya EN, Smeltzer MS. Photothermal nanotherapeutics and nanodiagnostics for selective killing of bacteria targeted with gold nanoparticles. Biophys J. 2006 Jan 15; 90(2):619-27. PMID: 16239330; PMCID: PMC1367066.
    83. Nelson CL, McLaren AC, McLaren SG, Johnson JW, Smeltzer MS. Is aseptic loosening truly aseptic? Clin Orthop Relat Res. 2005 Aug; (437):25-30. PMID: 16056022.
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    84. Cassat JE, Dunman PM, McAleese F, Murphy E, Projan SJ, Smeltzer MS. Comparative genomics of Staphylococcus aureus musculoskeletal isolates. J Bacteriol. 2005 Jan; 187(2):576-92. PMID: 15629929; PMCID: PMC543526.
    85. Nelson CL, McLaren AC, McLaren SG, Johnson JW, Smeltzer M. Is aseptic loosening really aseptic?. Clinical Orthopaedics and Related Research. 2005; 437:25-30.
    86. Jones-Jackson L, Walker R, Purnell G, McLaren SG, Skinner RA, Thomas JR, Suva L, Anaissie E, Miceli M, Nelson CL, Ferris E, Smeltzer M. Early detection of bone infection and differentiation form post-surgical inflammation using 2-deoxy-2-[18F]-fluoro-D-glucose positron emission tomography (FDG-PET) in an animal model. Journal of Orthopaedic Research. 2005; 23:1484-1489.
    87. Koenig RL, Ray JL, Maleki SJ, Smeltzer MS, Hurlburt BK. Staphylococcus aureus AgrA binding to the RNAIII-agr regulatory region. J Bacteriol. 2004 Nov; 186(22):7549-55. PMID: 15516566; PMCID: PMC524880.
    88. O'Leary JO, Langevin MJ, Price CT, Blevins JS, Smeltzer MS, Gustafson JE. Effects of sarA inactivation on the intrinsic multidrug resistance mechanism of Staphylococcus aureus. FEMS Microbiol Lett. 2004 Aug 15; 237(2):297-302. PMID: 15321676.
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    89. Beenken KE, Dunman PM, McAleese F, Macapagal D, Murphy E, Projan SJ, Blevins JS, Smeltzer MS. Global gene expression in Staphylococcus aureus biofilms. J Bacteriol. 2004 Jul; 186(14):4665-84. PMID: 15231800; PMCID: PMC438561.
    90. O'Leary JO, Langevin MJ, Price CTD, Blevins JS, Smeltzer M, Gustafson JE. Effects of sarA inactivation on the intrinsic multidrug resistance mechanisms of Staphylococcus aureus. FEMS Microbiol. Lett. 2004; 237:297-302.
    91. Koenig RL, Ray JL, Maleki SJ, Smeltzer M, Hurlburt BK. Staphylococcal aureus AgrA binding to the RNAIII-agr regulatory region. Journal of Bacteriology. 2004; 186:7549-7555.
    92. Sterba KM, Mackintosh SG, Blevins JS, Hurlburt BK, Smeltzer MS. Characterization of Staphylococcus aureus SarA binding sites. J Bacteriol. 2003 Aug; 185(15):4410-7. PMID: 12867449; PMCID: PMC165759.
    93. Beenken KE, Blevins JS, Smeltzer MS. Mutation of sarA in Staphylococcus aureus limits biofilm formation. Infect Immun. 2003 Jul; 71(7):4206-11. PMID: 12819120; PMCID: PMC161964.
    94. Blevins JS, Elasri MO, Allmendinger SD, Beenken KE, Skinner RA, Thomas JR, Smeltzer MS. Role of sarA in the pathogenesis of Staphylococcus aureus musculoskeletal infection. Infect Immun. 2003 Jan; 71(1):516-23. PMID: 12496203; PMCID: PMC143404.
    95. Beenken KE, Blevins JS, Smeltzer M. Mutation of sarA impairs biofilm formation in Stapjylococcus aureus SarA binding sites. Infection and Immunity. 2003; 71:4206-4211.
    96. Blevins JS, Elasri MO, Skinner RA, Thomas JR, Smeltzer M. Role of sarA in the pathogenesis of Staphylococcus aureus muskoskeletal infection. Infection and Immunity. 2003; 71:516-523.
    97. Nguyen LL, Nelson CL, Saccente M, Smeltzer MS, Wassell DL, McLaren SG. Detecting bacterial colonization of implanted orthopaedic devices by ultrasonication. Clin Orthop Relat Res. 2002 Oct; (403):29-37. PMID: 12360004.
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    98. Nelson CL, McLaren SG, Skinner RA, Smeltzer MS, Thomas JR, Olsen KM. The treatment of experimental osteomyelitis by surgical debridement and the implantation of calcium sulfate tobramycin pellets. J Orthop Res. 2002 Jul; 20(4):643-7. PMID: 12168649.
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    99. Blevins JS, Beenken KE, Elasri MO, Hurlburt BK, Smeltzer MS. Strain-dependent differences in the regulatory roles of sarA and agr in Staphylococcus aureus. Infect Immun. 2002 Feb; 70(2):470-80. PMID: 11796572; PMCID: PMC127691.
    100. Elasri MO, Thomas JR, Skinner RA, Blevins JS, Beenken KE, Nelson CL, Smeltzer M. Staphylococcus aureus collagen adhesion contributes to the pathogenesis of osteomyelitis. Bone. 2002; 30:275-280.
    101. Nelson CL, McLaren SG, Skinner RA, Smeltzer M, Thomas JR, Olsen KM. Treatment of experimental osteomyelitis by surgical debridement and the implantation of calcium sulfate tobramycin pellets. Journal of Orthopaedic Research. 2002; 20:643-647.
    102. Smeltzer M, Nelson CL. Staphylococcus aureus Infection and Disease. Osteomyrlitis and septic arthritis. 2001; Pgs. 213-246.
    103. Smeltzer M, Gillaspy AF. Molecular pathogenesis of staphylococcal osteomyelitis. Poultry Science. 2000; 79:1042-1049.
    104. Smeltzer M. Handbook for Studying Bacterial Adhesion. Characterization of staphylococcal adhesins for adherence to host tissues. 2000; Pgs. 411-444.
    105. Snodgrass JL, Mohammed N, Ross JM, Sau S, Lee CY, Smeltzer M. Functional characterization of the Staphylococcus aureus collagen adhesion B domain. Infection and Immunity. 1999; 67:3952-3959.
    106. Blevins JS, Gillaspy AF, Rechtin TM, Hurlburt BK, Smeltzer M. The staphylococcal accessory regulator (sar) controls expression of the Staphylococcus aureus collagen adhesion gene (cna) in an agr-independent manner. Molecular Microbiology. 1999; 33:317-326.
    107. Rechtin TM, Gillaspy AF, Schumacher M, Brennan RG, Smeltzer M, Hurlburt BK. Characterization of SarA virulence gene regulator of Staphylococcus aureus. Molecular Microbiology. 1999; 33:307-316.
    108. Smeltzer M, Gillaspy AF, Pratt FL Jr, Thames MD. Comparative evaluation of cna, fnbA, fnbB and hlb genomic fingerprinting for the epidemiological typing of Staphylococcus aureus. Journal of Clinical Microbiology. 1997; 35:2444-2449.
    109. Gillaspy AF, Patti JM, Pratt FL Jr, Smeltzer M. Transcriptional regulation of the staphylococcus aureus collagen adhesin gene (cna). Infection and Immunity. 1997; 65:1536-1540.
    110. Smeltzer M, Gillaspy AF, Pratt FL, Iandolo JJ. Prevalence and chromosomal map location of Staphylococcus aureus adhesion genes. Gene. 1997; 196:249-259.
    111. Smeltzer M, Pratt FL Jr, Gillaspy AF, Young LA. Genomic fingerprinting for the epidemiological differentiation of Staphylococcus aureus clinical isolates. Journal of Clinical Microbiology. 1996; 34:1364-1372.
    112. Gillaspy AF, Hickmon SG, Skinner RA, Thomas JR, Nelson CL, Smeltzer M. Role of the accessory gene regulator (agr) in the pathogenesis of staphylococcal osteomyelitis. Infection and Immunity. 1995; 63:3373-3380.
    113. Smeltzer M, Hart ME, Iandolo JJ. Quantitative spectrophotometric assay for lipase activity in Staphylococcus aureus. Appl. Environ. Microbiol. 1992; 58:2815-2819.
    114. Rahaley RS, Dennis SM, Smeltzer M. Comparison of the enzyme-linked immunosorbent assay and complement fixation test for detecting Brucella ovis antibodies in sheep. Veterinary Record. 1983; 113:467-470.
    115. Smeltzer M. The Role of Biofilms in Device-Related Infections. Biofilms and aseptic loosening.
    116. Smeltzer M. The Staphylococci in Human Disease. The molecular basis of pathogenicity.
    117. Smeltzer M, Darville T, Saccente M, Nelson CL. Infectious Disease and Theraphy. Staphylococcal osteomyelitis.
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