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Brian Varisco

TitleProfessor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentCOM | Peds Critical Care
Address4301 W Markham
Little Rock AR 72205
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    Collapse Research 
    Collapse research activities and funding
    R13HL142277     (VARISCO, BRIAN MICHAEL)Jul 1, 2018 - Jun 30, 2019
    NIH
    FASEB SRC on The Lung Epithelium in Health and Disease
    Role: Principal Investigator
    R01HL141229     (VARISCO, BRIAN MICHAEL)Apr 15, 2018 - Mar 31, 2024
    NIH
    Chymotrypsin-like Elastase 1 in Lung Development and Disease
    Role: Principal Investigator
    K08HL131261     (VARISCO, BRIAN MICHAEL)Jan 7, 2016 - Dec 31, 2019
    NIH
    Cela1 Mediates Stretch-regulated Elastin Remodeling During Alveolar Septation
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Devine AJ, Smith NJ, Joshi R, Brooks-Patton B, Dunham J, Varisco AN, Goodman EM, Fan Q, Zingarelli B, Varisco BM. KF4 anti-CELA1 Antibody and Purified a1-Antitrypsin Have Similar but Not Additive Efficacy in Preventing Emphysema in Murine a1-Antitrypsin Deficiency. bioRxiv. 2024 May 10. PMID: 38766202.
      View in: PubMed
    2. Whitney JE, Johnson GM, Varisco BM, Raby BA, Yehya N. Biomarker-Based Risk Stratification Tool in Pediatric Acute Respiratory Distress Syndrome: Single-Center, Longitudinal Validation in a 2014-2019 Cohort. Pediatr Crit Care Med. 2024 Jul 01; 25(7):599-608. PMID: 38591949.
      View in: PubMed
    3. Yehya N, Booth TJ, Ardhanari GD, Thompson JM, Lam LKM, Till JE, Mai MV, Keim G, McKeone DJ, Halstead ES, Lahni P, Varisco BM, Zhou W, Carpenter EL, Christie JD, Mangalmurti NS. Inflammatory and tissue injury marker dynamics in pediatric acute respiratory distress syndrome. J Clin Invest. 2024 Apr 04; 134(10). PMID: 38573766.
      View in: PubMed
    4. Ojha M, Smith NJ, Devine AJ, Joshi R, Goodman EM, Fan Q, Schuman R, Porollo A, Wells JM, Tiwary E, Batie MR, Gray J, Deshmukh H, Borchers MT, Ammerman SA, Varisco BM. Anti-CELA1 antibody KF4 prevents emphysema by inhibiting stretch-mediated remodeling. JCI Insight. 2024 Jan 09; 9(1). PMID: 38193533.
      View in: PubMed
    5. Atreya MR, Banerjee S, Lautz AJ, Alder MN, Varisco BM, Wong HR, Muszynski JA, Hall MW, Sanchez-Pinto LN, Kamaleswaran R. Machine learning-driven identification of the gene-expression signature associated with a persistent multiple organ dysfunction trajectory in critical illness. EBioMedicine. 2024 Jan; 99:104938. PMID: 38142638.
      View in: PubMed
    6. Wang F, Ting C, Riemondy KA, Douglas M, Foster K, Patel N, Kaku N, Linsalata A, Nemzek J, Varisco BM, Cohen E, Wilson JA, Riches DW, Redente EF, Toivola DM, Zhou X, Moore BB, Coulombe PA, Omary MB, Zemans RL. Regulation of epithelial transitional states in murine and human pulmonary fibrosis. J Clin Invest. 2023 11 15; 133(22). PMID: 37768734.
      View in: PubMed
    7. Devine AJ, Smith NJ, Joshi R, Fan Q, Borchers MT, Clair GC, Adkins JN, Varisco BM. Chymotrypsin-like Elastase-1 Mediates Progressive Emphysema in Alpha-1 Antitrypsin Deficiency. Chronic Obstr Pulm Dis. 2023 Oct 26; 10(4):380-391. PMID: 37534975.
      View in: PubMed
    8. Joshi I, Devine AJ, Joshi R, Smith NJ, Varisco BM. A titratable murine model of progressive emphysema using tracheal porcine pancreatic elastase. Sci Rep. 2023 09 14; 13(1):15259. PMID: 37709810.
      View in: PubMed
    9. Williams JG, Jones RL, Yunger TL, Lahni PM, Yehya N, Varisco BM. Comparison of 16 Pediatric Acute Respiratory Distress Syndrome-Associated Plasma Biomarkers With Changing Lung Injury Severity. Pediatr Crit Care Med. 2024 Jan 01; 25(1):e31-e40. PMID: 37382480.
      View in: PubMed
    10. Varisco BM. Nuclear Factor-?B Keeps Basal Cells Undifferentiated in Congenital Diaphragmatic Hernia. Am J Respir Crit Care Med. 2023 05 01; 207(9):1122-1123. PMID: 36883942.
      View in: PubMed
    11. Ishaque S, Famularo ST, Saleem AF, Siddiqui NUR, Kazi Z, Parkar S, Hotwani A, Thomas NJ, Thompson JM, Lahni P, Varisco B, Yehya N. Biomarker-Based Risk Stratification in Pediatric Sepsis From a Low-Middle Income Country. Pediatr Crit Care Med. 2023 Jul 01; 24(7):563-573. PMID: 37092821.
      View in: PubMed
    12. Devine AJ, Smith NJ, Joshi R, Fan Q, Borchers MT, Clair GC, Adkins JN, Varisco BM. CELA1 Mediates Progressive Emphysema in Alpha-1 Antitrypsin Deficiency. Res Sq. 2023 Feb 23. PMID: 36865303.
      View in: PubMed
    13. Varisco BM, Devaskar SU, Murray KO, Cheng TL. The Advanced Research Projects Agency-Health (ARPA-H): a new model for research in child health. Pediatr Res. 2023 02; 93(3):451-452. PMID: 36481786.
      View in: PubMed
    14. Williams JG, Joshi R, Haslam D, Yehya N, Jones RL, Paranjpe A, Pujato M, Roskin KM, Lahni PM, Wong HR, Varisco BM. Multi-omic characterization of pediatric ARDS via nasal brushings. Respir Res. 2022 Jul 09; 23(1):181. PMID: 35804409.
      View in: PubMed
    15. Varisco BM. In Memoriam: Hector R. Wong, MD (1963-2022). Pediatr Crit Care Med. 2022 May 01; 23(5):341-343. PMID: 35583615.
      View in: PubMed
    16. Serapiglia V, Stephens CA, Joshi R, Aydin E, Oria M, Marotta M, Peiro JL, Varisco BM. Fetal Tracheal Occlusion Increases Lung Basal Cells via Increased Yap Signaling. Front Pediatr. 2021; 9:780166. PMID: 35280447.
      View in: PubMed
    17. Joshi R, Batie MR, Fan Q, Varisco BM. Mouse lung organoid responses to reduced, increased, and cyclic stretch. Am J Physiol Lung Cell Mol Physiol. 2022 01 01; 322(1):L162-L173. PMID: 34851724.
      View in: PubMed
    18. Aydin E, Joshi R, Oria M, Lim FY, Varisco BM, Peiro JL. Transuterine Fetal Tracheal Occlusion Model in Mice. J Vis Exp. 2021 02 05; (168). PMID: 33616107.
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    19. Maxwell AR, Frazier M, Varisco BM. High-Frequency Jet Ventilation Is Making Slow Inroads to the Pediatric ICU. Respir Care. 2021 02; 66(2):349-350. PMID: 33514662.
      View in: PubMed
    20. Yehya N, Varisco BM, Thomas NJ, Wong HR, Christie JD, Feng R. Peripheral blood transcriptomic sub-phenotypes of pediatric acute respiratory distress syndrome. Crit Care. 2020 12 07; 24(1):681. PMID: 33287889.
      View in: PubMed
    21. Thomen RP, Woods JC, Sturm PF, Jain V, Walkup LL, Higano NS, Quirk JD, Varisco BM. Lung microstructure in adolescent idiopathic scoliosis before and after posterior spinal fusion. PLoS One. 2020; 15(10):e0240265. PMID: 33031412.
      View in: PubMed
    22. Niedbalski PJ, Cochran AS, Freeman MS, Guo J, Fugate EM, Davis CB, Dahlke J, Quirk JD, Varisco BM, Woods JC, Cleveland ZI. Validating in vivo hyperpolarized 129 Xe diffusion MRI and diffusion morphometry in the mouse lung. Magn Reson Med. 2021 04; 85(4):2160-2173. PMID: 33017076.
      View in: PubMed
    23. Joshi R, Ojha M, Lewis J, Fan Q, Monia B, Guo S, Varisco BM. Sex-specific differences in emphysema using a murine antisense oligonucleotide model of a-1 antitrypsin deficiency. Am J Physiol Lung Cell Mol Physiol. 2019 06 01; 316(6):L1165-L1173. PMID: 31017014.
      View in: PubMed
    24. Peiro JL, Oria M, Aydin E, Joshi R, Cabanas N, Schmidt R, Schroeder C, Marotta M, Varisco BM. Proteomic profiling of tracheal fluid in an ovine model of congenital diaphragmatic hernia and fetal tracheal occlusion. Am J Physiol Lung Cell Mol Physiol. 2018 12 01; 315(6):L1028-L1041. PMID: 30260286.
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    25. Joshi R, Heinz A, Fan Q, Guo S, Monia B, Schmelzer CEH, Weiss AS, Batie M, Parameshwaran H, Varisco BM. Role for Cela1 in Postnatal Lung Remodeling and Alpha-1 Antitrypsin-Deficient Emphysema. Am J Respir Cell Mol Biol. 2018 08; 59(2):167-178. PMID: 29420065.
      View in: PubMed
    26. Aydin E, Joshi R, Oria M, Varisco BM, Lim FY, Peiro JL. Fetal tracheal occlusion in mice: a novel transuterine method. J Surg Res. 2018 09; 229:311-315. PMID: 29937007.
      View in: PubMed
    27. Ganatra HA, Varisco BM, Harmon K, Lahni P, Opoka A, Wong HR. Zinc supplementation leads to immune modulation and improved survival in a juvenile model of murine sepsis. Innate Immun. 2017 01; 23(1):67-76. PMID: 27821649.
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    28. Atkinson SJ, Varisco BM, Sandquist M, Daly MN, Klingbeil L, Kuethe JW, Midura EF, Harmon K, Opaka A, Lahni P, Piraino G, Hake P, Zingarelli B, Mortenson JE, Wynn JL, Wong HR. Matrix Metalloproteinase-8 Augments Bacterial Clearance in a Juvenile Sepsis Model. Mol Med. 2016 Oct; 22:455-463. PMID: 27506554.
      View in: PubMed
    29. Daly MC, Atkinson SJ, Varisco BM, Klingbeil L, Hake P, Lahni P, Piraino G, Wu D, Hogan SP, Zingarelli B, Wong HR. Role of matrix metalloproteinase-8 as a mediator of injury in intestinal ischemia and reperfusion. FASEB J. 2016 10; 30(10):3453-3460. PMID: 27435263.
      View in: PubMed
    30. Varisco BM, Sbragia L, Chen J, Scorletti F, Joshi R, Wong HR, Lopes-Figueira R, Oria M, Peiro J. Excessive Reversal of Epidermal Growth Factor Receptor and Ephrin Signaling Following Tracheal Occlusion in Rabbit Model of Congenital Diaphragmatic Hernia. Mol Med. 2016 Sep; 22:398-411. PMID: 27452320.
      View in: PubMed
    31. Joshi R, Liu S, Brown MD, Young SM, Batie M, Kofron JM, Xu Y, Weaver TE, Apsley K, Varisco BM. Stretch regulates expression and binding of chymotrypsin-like elastase 1 in the postnatal lung. FASEB J. 2016 Feb; 30(2):590-600. PMID: 26443822.
      View in: PubMed
    32. Young SM, Liu S, Joshi R, Batie MR, Kofron M, Guo J, Woods JC, Varisco BM. Localization and stretch-dependence of lung elastase activity in development and compensatory growth. J Appl Physiol (1985). 2015 Apr 01; 118(7):921-31. PMID: 25614601.
      View in: PubMed
    33. Liu S, Cimprich J, Varisco BM. Mouse pneumonectomy model of compensatory lung growth. J Vis Exp. 2014 Dec 17; (94). PMID: 25549004.
      View in: PubMed
    34. Liu S, Young SM, Varisco BM. Dynamic expression of chymotrypsin-like elastase 1 over the course of murine lung development. Am J Physiol Lung Cell Mol Physiol. 2014 Jun 15; 306(12):L1104-16. PMID: 24793170.
      View in: PubMed
    35. Liu S, Parameswaran H, Young SM, Varisco BM. JNK suppresses pulmonary fibroblast elastogenesis during alveolar development. Respir Res. 2014 Mar 25; 15:34. PMID: 24661418.
      View in: PubMed
    36. Cornett B, Snowball J, Varisco BM, Lang R, Whitsett J, Sinner D. Wntless is required for peripheral lung differentiation and pulmonary vascular development. Dev Biol. 2013 Jul 01; 379(1):38-52. PMID: 23523683.
      View in: PubMed
    37. Varisco BM, Ambalavanan N, Whitsett JA, Hagood JS. Thy-1 signals through PPAR? to promote lipofibroblast differentiation in the developing lung. Am J Respir Cell Mol Biol. 2012 Jun; 46(6):765-72. PMID: 22268140.
      View in: PubMed
    38. Wong HR, Cvijanovich NZ, Allen GL, Thomas NJ, Freishtat RJ, Anas N, Meyer K, Checchia PA, Lin R, Shanley TP, Bigham MT, Wheeler DS, Doughty LA, Tegtmeyer K, Poynter SE, Kaplan JM, Chima RS, Stalets E, Basu RK, Varisco BM, Barr FE. Validation of a gene expression-based subclassification strategy for pediatric septic shock. Crit Care Med. 2011 Nov; 39(11):2511-7. PMID: 21705885.
      View in: PubMed
    39. Varisco BM. The pharmacology of acute lung injury in sepsis. Adv Pharmacol Sci. 2011; 2011:254619. PMID: 21738527.
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    40. Tofil NM, Benner KW, Zinkan L, Alten J, Varisco BM, White ML. Pediatric intensive care simulation course: a new paradigm in teaching. J Grad Med Educ. 2011 Mar; 3(1):81-7. PMID: 22379527.
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    41. Sanders YY, Tollefsbol TO, Varisco BM, Hagood JS. Epigenetic regulation of thy-1 by histone deacetylase inhibitor in rat lung fibroblasts. Am J Respir Cell Mol Biol. 2011 Jul; 45(1):16-23. PMID: 20724553.
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    42. Varisco BM, Palmatier CM, Alten JA. Reversal of intractable hypoxemia with exogenous surfactant (calfactant) facilitating complete neurological recovery in a pediatric drowning victim. Pediatr Emerg Care. 2010 Aug; 26(8):571-3. PMID: 20693854.
      View in: PubMed
    43. Varisco BM, Benner KW, Prabhakaran P. Neonatal peritoneal candidiasis successfully treated with anidulafungin add-on therapy. Ann Pharmacother. 2009 Nov; 43(11):1907-10. PMID: 19826094.
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    44. Varisco B, McAlvin B, Dias J, Franga D. Adenocarcinoid of the appendix: is right hemicolectomy necessary? A meta-analysis of retrospective chart reviews. Am Surg. 2004 Jul; 70(7):593-9. PMID: 15279181.
      View in: PubMed
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