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Jason Farrar

TitleAssistant Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPediatrics, College of Medicine
DivisionPeds Hematology
Address9-123 Cancer Institute
4104 Outpatient Circle
Mail Slot # 512-10
Little Rock AR 72205
Phone501-603-1224
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Gore L, Triche TJ, Farrar JE, Wai D, Legendre C, Gooden GC, Liang WS, Carpten J, Lee D, Alvaro F, Macy ME, Arndt C, Barnette P, Cooper T, Martin L, Narendran A, Pollard J, Meshinchi S, Boklan J, Arceci RJ, Salhia B. A multicenter, randomized study of decitabine as epigenetic priming with induction chemotherapy in children with AML. Clin Epigenetics. 2017; 9:108. PMID: 29034009.
      View in: PubMed
    2. Farrar JE, Neuberg D, Triche T, Bodine DM. Response: Making "perfect" the enemy of good. Blood. 2017 Aug 31; 130(9):1168-1169. PMID: 28754684.
      View in: PubMed
    3. O'Brien KA, Farrar JE, Vlachos A, Anderson SM, Tsujiura CA, Lichtenberg J, Blanc L, Atsidaftos E, Elkahloun A, An X, Ellis SR, Lipton JM, Bodine DM. Molecular convergence in ex vivo models of Diamond-Blackfan anemia. Blood. 2017 Jun 08; 129(23):3111-3120. PMID: 28377399.
      View in: PubMed
    4. Maxson JE, Ries RE, Wang YC, Gerbing RB, Kolb EA, Thompson SL, Guidry Auvil JM, Marra MA, Ma Y, Zong Z, Mungall AJ, Moore R, Long W, Gesuwan P, Davidsen TM, Hermida LC, Hughes SB, Farrar JE, Radich JP, Smith MA, Gerhard DS, Gamis AS, Alonzo TA, Meshinchi S. CSF3R mutations have a high degree of overlap with CEBPA mutations in pediatric AML. Blood. 2016 Jun 16; 127(24):3094-8. PMID: 27143256; PMCID: PMC4911865 [Available on 06/16/17].
    5. Farrar JE, Schuback HL, Ries RE, Wai D, Hampton OA, Trevino LR, Alonzo TA, Guidry Auvil JM, Davidsen TM, Gesuwan P, Hermida L, Muzny DM, Dewal N, Rustagi N, Lewis LR, Gamis AS, Wheeler DA, Smith MA, Gerhard DS, Meshinchi S. Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse. Cancer Res. 2016 04 15; 76(8):2197-205. PMID: 26941285; PMCID: PMC4873364 [Available on 04/15/17].
    6. Farrar JE, Quarello P, Fisher R, O'Brien KA, Aspesi A, Parrella S, Henson AL, Seidel NE, Atsidaftos E, Prakash S, Bari S, Garelli E, Arceci RJ, Dianzani I, Ramenghi U, Vlachos A, Lipton JM, Bodine DM, Ellis SR. Exploiting pre-rRNA processing in Diamond Blackfan anemia gene discovery and diagnosis. Am J Hematol. 2014 Oct; 89(10):985-91. PMID: 25042156; PMCID: PMC4332597.
    7. Ochs MF, Farrar JE, Considine M, Wei Y, Meshinchi S, Arceci RJ. Outlier Analysis and Top Scoring Pair for Integrated Data Analysis and Biomarker Discovery. IEEE/ACM Trans Comput Biol Bioinform. 2014 May-Jun; 11(3):520-32. PMID: 26356020; PMCID: PMC4156935.
    8. Farrar JE. Diamond Blackfan anemia: a Cheshire cat of hematology. Pediatr Blood Cancer. 2014 Jul; 61(7):1154-5. PMID: 24634369; PMCID: PMC4255456.
    9. Vlachos A, Farrar JE, Atsidaftos E, Muir E, Narla A, Markello TC, Singh SA, Landowski M, Gazda HT, Blanc L, Liu JM, Ellis SR, Arceci RJ, Ebert BL, Bodine DM, Lipton JM. Diminutive somatic deletions in the 5q region lead to a phenotype atypical of classical 5q- syndrome. Blood. 2013 Oct 03; 122(14):2487-90. PMID: 23943650; PMCID: PMC3790513.
    10. Ochs MF, Farrar JE, Considine M, Wei Y, Meschinchi S, Arceci RJ. Outlier Gene Set Analysis Combined with Top Scoring Pair Provides Robust Biomarkers of Pathway Activity. 8th IAPR International Conference on Pattern Recognition in Bioinformatics. 2013.
    11. Vlachos A, Farrar JE, Atsidaftos E, Muir E, Markello TC, Singh S, Liu JM, Ellis SR, Arceci RJ, Bodine D, Lipton J. 5q Myelodysplastic Syndrome (MDS) Masquerading as Diamond Blackfan Anemia [Abstract]. 25th Annual Meeting of the American Society of Pediatric Hematology Oncology. 2012; 1074.
    12. Markello TC, Carlson-Donohoe H, Sincan M, Adams D, Bodine DM, Farrar JE, Vlachos A, Lipton JM, Auerbach AD, Ostrander EA, Chandrasekharappa SC, Boerkoel CF, Gahl WA. Sensitive quantification of mosaicism using high density SNP arrays and the cumulative distribution function. Mol Genet Metab. 2012 Apr; 105(4):665-71. PMID: 22277120; PMCID: PMC3309164.
    13. Farrar JE, Vlachos A, Atsidaftos E, Carlson-Donohoe H, Markello TC, Arceci RJ, Ellis SR, Lipton JM, Bodine DM. Ribosomal protein gene deletions in Diamond-Blackfan anemia. Blood. 2011 Dec 22; 118(26):6943-51. PMID: 22045982; PMCID: PMC3245214.
    14. Farrar JE, Dahl N. Untangling the phenotypic heterogeneity of Diamond Blackfan anemia. Semin Hematol. 2011 Apr; 48(2):124-35. PMID: 21435509; PMCID: PMC3078697.
    15. Vlachos A, Farrar J, Atsidaftos E, Muir E, Markello TC, Singh S, Liu JM, Ellis S, Arceci RJ, Bodine DM, Lipton JM. 5q- Myelodysplastic Syndrome, In One of 23 Children Lacking a Known Ribosomal Gene Mutation, Masquerading as Diamond Blackfan Anemia (DBA) and Responding to Lenalidomide [Abstract]. American Society of Hematology Annual Meeting. 2010.
    16. Farrar JE, Vlachos A, Atsidaftos EA, Carlson-Donohoe H, Markello TC, Arceci RJ, Lipton JM, Bodine DM. SNP Array Genotyping Reveals Constitutional and Mosaic Losses of Ribosomal Protein Gene Regions In Patients with Diamond Blackfan Anemia without Ribosomal Protein Gene Mutations [Abstract]. American Society of Hematology Annual Meeting. 2010.
    17. Doherty L, Sheen MR, Vlachos A, Choesmel V, O'Donohue MF, Clinton C, Schneider HE, Sieff CA, Newburger PE, Ball SE, Niewiadomska E, Matysiak M, Glader B, Arceci RJ, Farrar JE, Atsidaftos E, Lipton JM, Gleizes PE, Gazda HT. Ribosomal protein genes RPS10 and RPS26 are commonly mutated in Diamond-Blackfan anemia. Am J Hum Genet. 2010 Feb 12; 86(2):222-8. PMID: 20116044; PMCID: PMC2820177.
    18. Moore JB, Farrar JE, Arceci RJ, Liu JM, Ellis SR. Distinct Ribosome Maturation Defects in Yeast Models for Diamond Blackfan Anemia and Shwachman Diamond Syndrome. Haematologica. 2010; 95(1):57-64.
    19. Noronha SA, Farrar JE, Alonzo TA, Gerbing RB, Lacayo NJ, Dahl GV, Ravindranath Y, Arceci RJ, Loeb DM. WT1 expression at diagnosis does not predict survival in pediatric AML: a report from the Children's Oncology Group. Pediatr Blood Cancer. 2009 Dec; 53(6):1136-9. PMID: 19618455; PMCID: PMC2926132.
    20. Heuston EF, Farrar JE, Triche T, Buckley J, Sorensen P, Reynolds P, Reaman G, Yegnasubramanian V, Arceci RA. Selective and Titratable Effects On AML Genome-wide Methylation Patterning, Transcription, and Clonogenicity Using Low Concentrations of 5-Aza-2’ Deoxycytidine [Abstract]. American Society of Hematology Annual Meeting. 2009.
    21. Moore JB, Farrar JE, Arceci RJ, Liu JM, Ellis SR. Distinct ribosome maturation defects in yeast models of Diamond-Blackfan anemia and Shwachman-Diamond syndrome. Haematologica. 2010 Jan; 95(1):57-64. PMID: 19713223; PMCID: PMC2805733.
    22. Suzuki T, Farrar JE, Yegnasubramanian S, Zahed M, Suzuki N, Arceci RJ. Stable knockdown of PASG enhances DNA demethylation but does not accelerate cellular senescence in TIG-7 human fibroblasts. Epigenetics. 2008 Sep; 3(5):281-91. PMID: 18948754; PMCID: PMC2746857.
    23. Farrar JE, Nater M, Caywood E, McDevitt MA, Kowalski J, Takemoto CM, Talbot CC, Meltzer P, Esposito D, Beggs AH, Schneider HE, Grabowska A, Ball SE, Niewiadomska E, Sieff CA, Vlachos A, Atsidaftos E, Ellis SR, Lipton JM, Gazda HT, Arceci RJ. Abnormalities of the large ribosomal subunit protein, Rpl35a, in Diamond-Blackfan anemia. Blood. 2008 Sep 01; 112(5):1582-92. PMID: 18535205; PMCID: PMC2518874.
    24. Farrar J, Nater M, Caywood EH, McDevitt M, Kowalski J, Takemoto CM, Meltzer P, Beggs AH, Schneider HA, Grabowska A, Ball S, Niewiadomska E, Sieff CA, Vlachos A, Atsidaftos E, Lipton JM, Gazda HT, Arceci RA. A Large Subunit Abnormality in Diamond-Blackfan Anemia (DBA) [Abstract]. American Society of Hematology Annual Meeting. 2007; 422.
    25. Farrar JE, Rohrer J, Conley ME. Neutropenia in X-Linked. Clin Immunol Immunopathol. 1996; 81(3):271-6.
    26. Farrar JE, Gazda HT, Beggs AH, Atsidaftos E, Arceci RA, Lipton JM, Vlachos A. Sequence Abnormalities In Genes Encoding Ribosomal Proteins In Patients With Diamond Blackfan Anemia: A Preliminary Report from the Resequencing Project [Abstract].
    27. Meshinchi S, Ries RE, Trevino LR, Hampton OA, Alonzo TA, Farrar JE, Guidry-Auvil J, Davidsen TM, Gesuwan P, Muzny DM, Gamis AS, Helton HL, Wheeler DA, Smith MA, Gerhard DS, Arceci RJ. Identification of Novel Somatic Mutations, Regions of Recurrent Loss of Heterozygosity (LOH) and Significant Clonal Evolution from Diagnosis to Relapse in Childhood AML Determined by Exome Capture Sequencing – An NCI/COG TARGET AML Study. American Society of Hematology Annual Meeting.
    28. Ellis SR, Moore JB, Pavesi E, Dianzani I, Farrar J, Arceci RJ, Vlachos A, Lipton JM, Liu JM. Diamond Blackfan anemia: What’s the 5S ribonucleoprotein subcomplex got to do with it? [Abstract].
    29. Neuman DL, Farrar JE, Moresi JM, Vogelsang GB, Higman MA. Letter to: Toxic absorption of tacrolimus in a patient with severe acute graft-versus-host disease. Bone Marrow Transplant. 2006. (1):81.
    30. Caywood E, Farrar JE, Lipton JM, Arceci RJ. Differential Down-Regulation of RPL35a in Human Bone Marrow Progenitors Demonstrates a p53 Independent Mechanism Mediating the Diamond Blackfan Anemia Phenotype [Abstract]. American Society of Hematology Annual Meeting. 1096.
    31. Mendoza-Naranjo A, Wai DH, Farrar JE, Zhu Q, Mistry P, Lazic N, Ayala FRR, Da Cunha IW, Arceci RJ, Soares FA, Triche TJ, Strauss SJ, Sorensen PJ. ErbB4 is a Novel Driver of Metastasis and Anoikis Resistance in Ewing’s Sarcoma [Abstract].
    32. Fisher R, Henson AL, Quarello P, Aspesi A, Farrar JE, Arceci RJ, Bodine DM, Dianzani I, Lipton JM, Ramenghi U, Vlachos A, Ellis SR. Insights into diagnosis and etiology of Diamond Blackfan anemia by analysis of pre-rRNA processing [Abstract]. American Society of Hematology Annual Meeting.
    33. Moore JB, Farrar JE, Arceci RA, Liu J, Ellis SR. Yeast Models for Diamond Blackfan Anemia and Shwachman Diamond Syndrome Differ In Their Effect On Translation of Certain Classes of mRNA [Abstract].
    34. Williams D, Coates T, Shimamura A, Arceci RJ, Bennett C, Bertuch A, Bessler M, Chawla A, Corey SJ, Dror Y, Farrar J, Glader B, Hartung H, Hofmann I, Huang J, Kurre P, Lehmann L, Lipton J, Olson T, Reiss U, Rogers Z, Sieff C, Takemoto C, Vlachos A, Walkovich K, Wang W. Diagnosis and Treatment of Pediatric Acquired Aplastic Anemia (AAA): An Initial Study of the North American Pediatric Aplastic Anemia Consortium (NAPAAC). Pediatr Blood Cancer, 60; S1-105.
    35. Meshinchi S, Ries RE, Farrar JE, Guidry Auvil J, Davidsen TM, Gesuwan P, Trevino LR, Muzny DM, Wheeler DA, Gamis AS, Alonzo TA, Smith MA, Gerhard DS, Arceci RJ. Demonstration of Significant Clonal Evolution from Diagnosis to Relapse in Childhood AML Determined by Exome Capture Sequencing - An NCI/COG TARGET AML Study [Abstract].
    36. Farrar JE, Nater M, Caywood EH, McDevitt M, Kowalski J, Takemoto CM, Meltzer P, Beggs AH, Schneider HA, Grabowska A, Ball S, Niewiadomska E, Sieff CA, Vlachos A, Atsidaftos E, Lipton JM, Gazda HT, Arceci RA. A Large Subunit Abnormality in DBA [Abstract].
    37. Osorio DS, Atsidaftos E, Muir E, Seiden H, Gruber D, Farrar JE, Ellis SR, Glader B, Lipton JM, Vlachos A. Prevalence of Elevated Erythrocyte Adenosine Deaminase (eADA) Activity, A Marker of Diamond Blackfan Anemia (DBA), In Patients with Congenital Heart Disease (CHD). Pediatr Blood Cancer, 60; S1-105.
    38. Ochs MF, Farrar JE, Considine M, Ries R, Trevino LR, Alonzo TA, Guidry-Auvil J, Davidsen TM, Gesuwan P, Muzny DM, Gamis AS, Helton HL, Wheeler DA, Smith MA, Gerhard DS, Meshinchi S, Arceci RJ. Genome wide promoter methylation patterns predict AML subtype outcomes and identify novel pathways characterizing diagnostic and relapsed disease in children [Abstract]. American Society of Hematology Annual Meeting.
    39. Zhang L, Anglesio MS, O'Sullivan M, Zhang F, Yang G, Sarao S, Nghiem MP, Cronin S, Hara H, Melnyk N, Li L, Wada T, Farrar J, Arceci RJ, Liu PP, Sorensen PHB, Penninger JM. The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers. Nat Med. 13(9):1060-9.
    40. Vlachos A, Atsidaftos E, Arceci RJ, Ellis SR, Lipton JM, Bodine DM. The Frequent Identification of Ribosomal Protein Gene Deletions in Diamond Blackfan Anemia Patients without Detectable Ribosomal Protein Gene Mutations [Abstract].
    41. Caywood EH, Farrar JE, Lipton JM, Arceci RJ. Differential down-regulation of RPL35a in human bone marrow progenitors demonstrates a p53 independent mechanism mediating the Diamond Blackfan anemia phenotype.
    42. Heuston EF, Farrar JE, Triche T, Buckley J, Wai DH, Ochs M, Considine M, Reaman G, Arceci RJ. 5-Aza-2’-deoxycytidine and Cytarabine Mediate Distinct Effects on Clonogenic Growth, Genome-Wide Methylation and RNA Expression in AML [Abstract].
    43. Helton HL, Ries RE, Alonzo TA, Gerbing RB, Trevino LR, Farrar JE, Guidry-Auvil J, Davidsen TM, Gesuwan P, Muzny DM, Gamis AS, Franklin J, Wheeler DA, Smith MA, Gerhard DS, Arceci RJ, Meshinchi S. Clinically Significant Mutations, Deletions and Translocations involving ETV6 Identified by Whole Genome and Whole Exome Sequencing: a Report from NCI/COG TARGET AML Initiative [Abstract] 54th Annual ASH Meeting, Atlanta, GA. American Society of Hematology Annual Meeting.
    44. Arceci RA, Caywood E, Farrar JE, Nater M, Lipton JM. Down-regulation of Rpl35a and Rps19 in the UT-7/Epo Cell Line Results in Cell Cycle Arrest at G2/M [Abstract].
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