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Kalpana Padala

TitleAssociate Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentGeriatrics, College of Medicine
DivisionGeriatrics Faculty
Address VA 3J NLR
4301 W Markham St.
Mail Slot # 748
Little Rock AR 72205
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    Collapse Overview 
    Collapse overview
    I have fifteen years of experience in conducting treatment trials in frail elderly. I have focused on alternate modalities to promote exercise in elderly. To overcome various barriers for exercise, I conducted a series of studies investigating the feasibility and efficacy of Nintendo Wii-Fit on gait, and balance in various settings funded by the Alzheimer’s Association and the Department of Veterans Affairs. Later I focused on exercise adherence and ways to improve the same. My current study funded by the RR&D Merit grant is studying the efficacy and lasting effects of repetitive transcranial magnetic stimulation on executive function, exercise performance, self-efficacy and adherence to an adequately dosed, targeted Wii-Fit. The goal of the project is to improve various components of balance in sedentary older Veterans using engaging exercise programs in their home setting.

    Clinically, I evaluate patients in the multidisciplinary memory clinic at the VA. I also lead the comprehensive physical activity promotion clinic, The Geriatric Walking Clinic that I started in 2013. Over 800 Veterans and caregivers have participated in the program and the clinic provides us a naturalistic experiment to study the impact of COVID-19 restrictions on exercise adherence and executive function in older Veterans. Anecdotally, I see the impact of these restrictions on my clinic patients on a daily basis. I also see the struggles of older Veterans in transitioning to telehealth.

    Collapse Affiliation 
    Collapse clinical activities
    Director, Tele Memory Clinic, CAVHS, Little Rock, AR
    Director, Gait and Balance Laboratory, CAVHS, Little Rock, AR
    Director, Geriatric Walking Clinic, CAVHS, Little Rock, AR

    Collapse Biography 
    Collapse Leadership and Administrative Roles
    Associate Director for Clinical Research, VISN 16 GRECC

    Co-Chair, RR&D Committee, CAVHS

    Collapse awards and honors
    2023Outstanding QI Preceptor Award, UAMS
    2021Dr. Edith Irby Jones Excellence in Diversity and Inclusion Mid-Senior Career Faculty Award, UAMS
    2020Phenomenal Women Award, UAMS
    2020GRECC Clinical Star Award, CAVHS
    2019Academic Excellence Award, American Association of Physician of India origin (AAPI) Arkansas
    2019American Geriatrics Society Fellow (AGSF), American Geriatrics Society
    2019Physician Recognition Award, CAVHS
    2018Director’s Certificate of Recognition for exemplified exceptional service, CAVHS GRECC
    2018Gold Status Fellow – National Award , VHA Diffusion of Excellence for Health’s Promising Practices Consortium
    20181st place, Outstanding Posters and Presentations, 10th Annual Meeting of the American Association of Physicians of Indian Origin, Arkansas Chapter
    2017Director’s Certificate of Recognition for exemplified exceptional service, CAVHS GRECC
    2011American Geriatrics Society/ Merck 2011 New Investigator Award, American Geriatrics Society
    2011Vada Kinman - Oldfield Alzheimer’s Research Scholarship Fund Award, Kinman Oldfield Family Foundation
    2010Best Teacher Award, Department of Family Medicine, University of Nebraska Medical Center
    2009AMDA Foundation/Pfizer Quality Improvement Research Award, American Medical Director’s Association
    2008Travel Fellowship, New Investigators Technical Assistance Workshop, NIMH Health and Behavioral Research
    2007Nancy and Ronald Reagan Alzheimer’s Research Scholarship Fund Award, Kinman Oldfield Family Foundation
    2007Tracy Osborne Award, Nebraska Medical Director’s Association (NMDA)
    2006Futures Award, American Medical Director’s Association (AMDA)
    2006Kashinath Patil Award, Excellence in Research/Scholarly Activity, Department of Family Medicine, University of Nebraska Medical Center

    Collapse Research 
    Collapse research activities and funding
         (Ian Moore, PsyD)Sep 1, 2023 - Aug 31, 2024
    National Academy of Neuropsychology
    A rTMS and Virtual Reality Based Cognitive Rehabilitation Program for MCI
    Role: Co-Investigator

         (Kalpana Padala, MD)May 1, 2022 - Apr 30, 2026
    Department of Defense
    DNA Methylation Markers Associated with Exposure and Adverse Health Outcomes in Veterans Exposed to Airborne Hazards from Open Burn Pits
    Role: Principal Investigator

         (Prasad Padala, MD)Aug 16, 2021 - Aug 15, 2023
    Cerevel Therapeutics, LLC
    A Randomized, Double-Blind, Placebo-Controlled Trial To Evaluate The Safety, Tolerability, And Pharmacodynamics Of CVL-871 In Subjects With Dementia-Related Apathy
    Role: Co-Investigator

         (A’mie Preston, PsyD)Aug 1, 2021 - Jul 31, 2023
    VA ORD RRD – Diversity Supplement
    Immersive Virtual Reality for Apathy associated with Cognitive Impairment.
    Role Description: Role: Co-Mentor
    Role: Other

         (PADALA, KALPANA)Oct 1, 2020 - Dec 31, 2022
    Janssen Vaccines & Prevention B.V.
    A Randomized, Double-blind, Placebo-controlled Phase 3 Study to assess the Efficacy and Safety of Ad26COVS1 for the Prevention of SARS-CoV-2 mediated COVID-19 in Adults Aged 18 Years and Older
    Role Description: The study will test the efficacy and safety of Ad26COVS1 for the prevention of SARS-CoV-2 mediated COVID-19 in adults aged 18 years and older compared to that of a placebo.
    Role: Principal Investigator

    1I01RX002961-01A1     (PADALA, KALPANA)Oct 1, 2020 - Sep 30, 2021
    Department of Veterans Affairs
    COVID Impact on Physical Activity in Older Veterans
    Role: Principal Investigator

         (PADALA, KALPANA)Jul 2, 2020 - Oct 30, 2021
    Romark Medical Research Institute
    A Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Efficacy and Safety of Nitazoxanide (NTZ) for Post-Exposure Prophylaxis of COVID-19 and Other Viral Respiratory Illnesses in Elderly Residents of Long-Term Care Facilities (LTCF)
    Role: Co-Investigator

    I01RX002961     (PADALA, KALPANA P.)Apr 1, 2019 - Jan 31, 2024
    Neuromodulation for Exercise Adherence in Older Veterans
    Role: Principal Investigator

    1I01RX002638-01A2     (Prasad Padala)Sep 1, 2018 - Dec 31, 2022
    VA ORD RR&D Merit
    Transcranial Magnetic Stimulation for Apathy in Mild Cognitive Impairment
    Role: Co-Investigator

    R01AG052510     (LYKETSOS, CONSTANTINE G)Sep 30, 2016 - May 31, 2023
    Escitalopram for Agitation in Alzheimer Disease
    Role: Co-Investigator

    R01AG047992     (NEWHOUSE, PAUL A.)Sep 15, 2015 - May 31, 2021
    Long-Term Nicotine Treatment of Mild Cognitive Impairment
    Role: Co-Investigator

         (PADALA, KALPANA)Oct 1, 2012 - Sep 30, 2015
    South Central VA Health Care Network Research Grants
    Wii-Fit for balance and gait in elderly Veterans
    Role: Principal Investigator

         (PADALA, KALPANA)Sep 30, 2009 - Sep 1, 2014
    Alzheimer's Association
    Wii-Fit for improving activity, gait and balance in Alzheimer’s Dementia
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
    List All   |   Timeline
    1. Monga V, Petty F, Padala KP, Padala PR. . Topiramate monotherapy for Civilian Posttraumatic Stress Disorder: A controlled pilot study. 2023.
    2. Lanctôt KL, Rivet L, Tumati S, Perin J, Sankhe K, Vieira D, Mintzer J, Rosenberg PB, Shade D, Lerner AJ, Padala PR, Brawman-Mintzer O, van Dyck CH, Porsteinsson AP, Craft S, Levey AI, Padala KP and Herrmann N. . Heterogeneity of response to methylphenidate in apathetic patients in the ADMET 2 trial. 2023.
    3. Rhodes RL, Keller HE, Lensing S, Padala KP, Padala PR, Brown LM, Roberson PK, Sullivan DH. . The Influence of Social Determinants of Health on Mortality of Veterans Discharged from a Transitional Care Unit. 2023.
    4. Mena Lora AJ, Long JE, Huang Y, Baden LR, El Sahly HM, Follmann D, Goepfert P, Gray G, Grinsztejn B, Kotloff K, Rouphael N, Sobieszczyk M, Walsh SR, Andriesen J, Shah KA, Zhang Y, Gilbert P, Janes H, Gay CL, Falsey AR, Tripp RL, Gorman RL, Tong T, Marovich M, Neuzil K, Corey L, Kublin JG. Rapid Development of an Integrated Network Infrastructure to Conduct Phase 3 COVID-19 Vaccine Trials. JAMA Netw Open. 2023 Jan 03; 6(1):e2251974. PMID: 36689221.
      View in: PubMed
    5. Preston AM, Brown L, Padala KP, Padala PR. Veterans Affairs Health Care Provider Perceptions of Virtual Reality: Brief Exploratory Survey. Interact J Med Res. 2022 Sep 02; 11(2):e38490. PMID: 36053568.
      View in: PubMed
    6. Sadoff J, Gray G, Vandebosch A, C?rdenas V, Shukarev G, Grinsztejn B, Goepfert PA, Truyers C, Van Dromme I, Spiessens B, Vingerhoets J, Custers J, Scheper G, Robb ML, Treanor J, Ryser MF, Barouch DH, Swann E, Marovich MA, Neuzil KM, Corey L, Stoddard J, Hardt K, Ruiz-Gui?az? J, Le Gars M, Schuitemaker H, Van Hoof J, Struyf F, Douoguih M. Final Analysis of Efficacy and Safety of Single-Dose Ad26.COV2.S. N Engl J Med. 2022 03 03; 386(9):847-860. PMID: 35139271.
      View in: PubMed
    7. Katz IR, Rogers MP, Lew R, Thwin SS, Doros G, Ahearn E, Ostacher MJ, DeLisi LE, Smith EG, Ringer RJ, Ferguson R, Hoffman B, Kaufman JS, Paik JM, Conrad CH, Holmberg EF, Boney TY, Huang GD, Liang MH. Lithium Treatment in the Prevention of Repeat Suicide-Related Outcomes in Veterans With Major Depression or Bipolar Disorder: A Randomized Clinical Trial. JAMA Psychiatry. 2022 01 01; 79(1):24-32. PMID: 34787653.
      View in: PubMed
    8. Moo LR, Martinez E, Padala K, Dunay MA, Scali RR, Chen S, Thielke SM. Unexpected Findings During Double-blind Discontinuation of Acetylcholinesterase Inhibitor Medications. Clin Ther. 2021 06; 43(6):942-952. PMID: 34127273.
      View in: PubMed
    9. Sadoff J, Gray G, Vandebosch A, C?rdenas V, Shukarev G, Grinsztejn B, Goepfert PA, Truyers C, Fennema H, Spiessens B, Offergeld K, Scheper G, Taylor KL, Robb ML, Treanor J, Barouch DH, Stoddard J, Ryser MF, Marovich MA, Neuzil KM, Corey L, Cauwenberghs N, Tanner T, Hardt K, Ruiz-Gui?az? J, Le Gars M, Schuitemaker H, Van Hoof J, Struyf F, Douoguih M. Safety and Efficacy of Single-Dose Ad26.COV2.S Vaccine against Covid-19. N Engl J Med. 2021 06 10; 384(23):2187-2201. PMID: 33882225.
      View in: PubMed
    10. Padala KP, Wilson KB, Gauss CH, Stovall JD, Padala PR. VA Video Connect for Clinical Care in Older Adults in a Rural State During the COVID-19 Pandemic: Cross-Sectional Study. J Med Internet Res. 2020 09 30; 22(9):e21561. PMID: 32936773.
      View in: PubMed
    11. Padala PR, Jendro AM, Gauss CH, Orr LC, Dean KT, Wilson KB, Parkes CM, Padala KP. Participant and Caregiver Perspectives on Clinical Research During Covid-19 Pandemic. J Am Geriatr Soc. 2020 Jun; 68(6):E14-E18. PMID: 32315076.
      View in: PubMed
    12. Espinoza SE, Orsak B, Wang CP, MacCarthy D, Kellogg D, Powers B, Conde A, Moris M, Padala PR, Padala KP. An Individualized Low-Intensity Walking Clinic Leads to Improvement in Frailty Characteristics in Older Veterans. J Frailty Aging. 2019; 8(4):205-209. PMID: 31637407.
      View in: PubMed
    13. Dennis RA, Long DE, Landes RD, Padala KP, Padala PR, Garner KK, Wise JN, Peterson CA, Sullivan DH. Tutorial for using SliceOmatic to calculate thigh area and composition from computed tomography images from older adults. PLoS One. 2018; 13(10):e0204529. PMID: 30278056.
      View in: PubMed
    14. Scherer RW, Drye L, Mintzer J, Lanct?t K, Rosenberg P, Herrmann N, Padala P, Brawman-Mintzer O, Burke W, Craft S, Lerner AJ, Levey A, Porsteinsson A, van Dyck CH. The Apathy in Dementia Methylphenidate Trial 2 (ADMET 2): study protocol for a randomized controlled trial. Trials. 2018 Jan 18; 19(1):46. PMID: 29347996.
      View in: PubMed
    15. Dennis RA, Garner KK, Kortebein PM, Parkes CM, Bopp MM, Li S, Padala KP, Padala PR, Sullivan DH. Single-Arm Resistance Training Study to Determine the Relationship between Training Outcomes and Muscle Growth Factor mRNAs in Older Adults Consuming Numerous Medications and Supplements. J Nutr Health Aging. 2018; 22(2):269-275. PMID: 29380855.
      View in: PubMed
    16. Sullivan SC, Garner KK, Padala PR, Padala K, Taylor T, Nabholz L, Hunter C, Sullivan DH. "Bursting" out of the box: Process Improvement for in-service education. Medsurg Nurs. 2018; 5(27):297-99.
    17. Padala KP, Padala PR, Taylor T, Montgomery B, Lensing SY, Bopp MM, Dubbert PM, Sullivan DH. Development and implementation of geriatric walking clinic: a home based individualized Veteran centric program. Fed Pract. 2016; 33(8):44-47.
    18. Padala KP, Potter JP, Tsuneya I. HMGCoA-reductase inhibitors in dementia: Benefit or harm. Clinical Medicine: Geriatrics. 2009; (3):13-22.
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