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Xuming Zhang

TitleProfessor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentMicrobiology & Immunology, College of Medicine
DivisionMicrobiology & Immunology Faculty
Address521E Biomedical Research I
325 S. Elm St.
Mail Slot # 511
Little Rock AR 72205
Phone501-686-7415
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    Collapse Research 
    Collapse research activities and funding
    2970576300     (ZHANG, XUMING)Mar 1, 2022 - Dec 31, 2024
    US Department of Commerce - Pass Through: University of Arkansas at Fayetteville
    Scale-up of Continuous Manufacturing and Productization of Graphene for Advanced Respirator and Biosensor Applications
    Role: Principal Investigator
    2970576300-03     (ZHANG, XUMING)Mar 1, 2022 - Dec 31, 2024
    US Department of Commerce - Pass Through: University of Arkansas at Fayetteville
    Scale-up of Continuous Manufacturing and Productization of Graphene for Advanced Respirator and Biosensor Applications
    Role: Principal Investigator
    RO1HD090180     (TYCKO/YU)Sep 4, 2020 - Jun 30, 2024
    NIH - Pass Through: Roswell Park Comprehensive Cancer Center
    Epigenetics of Down Syndrome
    Role Description: The goal of this study is to evaluate the utility of a mouse model of Down syndrome for studying COVID-19 pathogenesis.
    Role: Principal Investigator
    U54AI057156     (ZHANG, XUMING)Dec 1, 2006 - Feb 28, 2009
    NIH/Nat. Inst. of Allergy & Infectious Diseases - Pass Through: University of Texas Medical Branch
    Development of Recombinant Pandemic Influenza Vaccines (Incoming Subc WIRED)
    Role: Principal Investigator
    P30NS047546     (DREW, PAUL D)Aug 15, 2004 - Jul 31, 2010
    NIH
    Neuroscience Research Center Core Facility at UAMS
    Role: Co-Investigator
    U01AI061204     (ZHANG, XUMING)Jul 1, 2004 - Jun 30, 2010
    NIH
    Developing recombinant coronavirus vaccines for SARS
    Role: Principal Investigator
    R01NS047499     (ZHANG, XUMING)Jul 1, 2004 - Apr 30, 2010
    NIH
    Demyelinating Disease-Viral and Cellular Function
    Role: Principal Investigator
    R21AI059244     (ZHANG, XUMING)Apr 1, 2004 - Mar 31, 2007
    NIH
    Developing a recombinanat vacine for SARS
    Role: Principal Investigator
    R01AI047188     (ZHANG, XUMING)Mar 15, 2000 - Feb 28, 2005
    NIH
    CORONAVIRUS RNA TRANSCRIPTION--VIRUS-HOST INTERACTION
    Role: Principal Investigator
    R21AI041515     (ZHANG, XUMING)Sep 1, 1999 - Aug 31, 2000
    NIH
    MECHANISM OF CORONAVIRUS RNA TRANSCRIPTION
    Role: Principal Investigator
    RPG-98-090-01     (ZHANG, XUMING)Jan 1, 1998 - Dec 31, 2001
    American Cancer Society (ACS)
    Regulation of Coronavirus RNA Transcription
    Role: Principal Investigator
    98-B-20     (ZHANG, XUMING)Sep 30, 1997 - Sep 30, 1998
    Arkansas Science and Technology Authority
    Mechanism of Coronavirus RNA Transcription
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Pechous RD, Malaviarachchi PA, Banerjee SK, Byrum SD, Alkam DH, Ghaffarieh A, Kurten RC, Kennedy JL, Zhang X. An ex vivo human precision-cut lung slice platform provides insight into SARS-CoV-2 pathogenesis and antiviral drug efficacy. J Virol. 2024 Jul 23; 98(7):e0079424. PMID: 38940558.
      View in: PubMed
    2. Pechous RD, Malaviarachchi PA, Banerjee SK, Byrum SD, Alkam DH, Ghaffarieh A, Kurten RC, Kennedy JL, Zhang X. An ex vivo human precision-cut lung slice platform provides insight into SARS-CoV-2 pathogenesis and antiviral drug efficacy. Journal of Virology. 2024.
    3. Pechous RD, Malaviarachchi PA, Xing Z, Douglas A, Crane SD, Theriot HM, Zhang Z, Ghaffarieh A, Huang L, Yu YE, Zhang X. SARS-CoV-2 Infection Causes Heightened Disease Severity and Mortality in a Mouse Model of Down Syndrome. Biomedicines. 2024 Feb 28; 12(3). PMID: 38540156.
      View in: PubMed
    4. Pechous RD, Malaviarachchi PA, Banerjee SK, Byrum SD, Alkam DH, Ghaffarieh A, Kurten RC, Kennedy JL, Zhang X. An ex vivo human precision-cut lung slice platform provides insight into SARS-CoV-2 pathogenesis and antiviral drug efficacy. bioRxiv. 2023 Apr 19. PMID: 37131640.
      View in: PubMed
    5. Chen XQ, Xing Z, Chen QD, Salvi RJ, Zhang X, Tycko B, Mobley WC, Yu YE. Mechanistic Analysis of Age-Related Clinical Manifestations in Down Syndrome. Front Aging Neurosci. 2021; 13:700280. PMID: 34276349.
      View in: PubMed
    6. Yang T, Li S, Zhang X, Pang X, Lin Q, Cao J. Resveratrol, sirtuins, and viruses. Rev Med Virol. 2015 Nov; 25(6):431-45. PMID: 26479742.
      View in: PubMed
    7. Zhang X, Liu Y, Cao J . Regulation of cellular microRNA expression in oligodendrocytes during acute and persistent coronavirus infection. Virology & Mycology. 2015; 4(1):138.
      View Publication
    8. Cao J, Forrest JC, Zhang X. A screen of the NIH Clinical Collection small molecule library identifies potential anti-coronavirus drugs. Antiviral Res. 2015 Feb; 114:1-10. PMID: 25451075.
      View in: PubMed
    9. Silva CS, Mullis LB, Pereira Jr O, Saif LJ, Vlasova A, Zhang X, Owens RJ, Paulson D, Taylor D, Haynes LM, Azevedo MP. Human respiratory coronaviruses detected in patients with influenza-like illness in Arkansas, USA. Virology & Mycology. 2014; S2(004).
      View Publication
    10. Cao J, Zhang X. Comparative in vivo analysis of the nsp15 endoribonuclease of murine, porcine and severe acute respiratory syndrome coronaviruses. Virus Res. 2012 Aug; 167(2):247-58. PMID: 22617024.
      View in: PubMed
    11. Zhang X. Challenges and opportunities in the development of therapeutics for viral infectious diseases in the 21st century. Virology & Mycology. 2012; 1(1):102.
      View Publication
    12. Mullis L, Saif LJ, Zhang Y, Zhang X, Azevedo MS. Stability of bovine coronavirus on lettuce surfaces under household refrigeration conditions. Food Microbiol. 2012 May; 30(1):180-6. PMID: 22265299.
      View in: PubMed
    13. Liu Y, Herbst W, Cao J, Zhang X. Deficient incorporation of spike protein into virions contributes to the lack of infectivity following establishment of a persistent, non-productive infection in oligodendroglial cell culture by murine coronavirus. Virology. 2011 Jan 05; 409(1):121-31. PMID: 21035161.
      View in: PubMed
    14. Li J, Liu Y, Zhang X. Murine coronavirus induces type I interferon in oligodendrocytes through recognition by RIG-I and MDA5. J Virol. 2010 Jul; 84(13):6472-82. PMID: 20427526.
      View in: PubMed
    15. Yu D, Zhu H, Liu Y, Cao J, Zhang X. Regulation of proinflammatory cytokine expression in primary mouse astrocytes by coronavirus infection. J Virol. 2009 Dec; 83(23):12204-14. PMID: 19776127.
      View in: PubMed
    16. Zhu H, Yu D, Zhang X. The spike protein of murine coronavirus regulates viral genome transport from the cell surface to the endoplasmic reticulum during infection. J Virol. 2009 Oct; 83(20):10653-63. PMID: 19570858.
      View in: PubMed
    17. Pu Y, Zhang X. Mouse hepatitis virus type 2 enters cells through a clathrin-mediated endocytic pathway independent of Eps15. J Virol. 2008 Aug; 82(16):8112-23. PMID: 18550663.
      View in: PubMed
    18. Liu Y, Zhang X. Murine coronavirus-induced oligodendrocyte apoptosis is mediated through the activation of the Fas signaling pathway. Virology. 2007 Apr 10; 360(2):364-75. PMID: 17156812.
      View in: PubMed
    19. Cai Y, Liu Y, Zhang X. Suppression of coronavirus replication by inhibition of the MEK signaling pathway. J Virol. 2007 Jan; 81(2):446-56. PMID: 17079328.
      View in: PubMed
    20. Han MG, Cheon DS, Zhang X, Saif LJ. Cross-protection against a human enteric coronavirus and a virulent bovine enteric coronavirus in gnotobiotic calves. J Virol. 2006 Dec; 80(24):12350-6. PMID: 16971444.
      View in: PubMed
    21. Cai Y, Liu Y, Zhang X. Induction of transcription factor Egr-1 gene expression in astrocytoma cells by Murine coronavirus infection. Virology. 2006 Nov 25; 355(2):152-63. PMID: 16908043.
      View in: PubMed
    22. Liu Y, Pu Y, Zhang X. Role of the mitochondrial signaling pathway in murine coronavirus-induced oligodendrocyte apoptosis. J Virol. 2006 Jan; 80(1):395-403. PMID: 16352564.
      View in: PubMed
    23. Zhu H, Liu Y, Cai Y, Yu D, Pu Y, Harmon L, Zhang X. Toward the development of an infectious cDNA clone of a human enteric coronavirus. Adv Exp Med Biol. 2006; 581:527-30. PMID: 17037591.
      View in: PubMed
    24. Yu D, Zhang X. Differential induction of proinflammatory cytokines in primary mouse astrocytes and microglia by coronavirus infection. Adv Exp Med Biol. 2006; 581:407-10. PMID: 17037569.
      View in: PubMed
    25. Liu Y, Zhang X. Persistent coronavirus infection of progenitor oligodendrocytes. Adv Exp Med Biol. 2006; 581:379-84. PMID: 17037563.
      View in: PubMed
    26. Liu Y, Zhang X. Expression of cellular oncogene Bcl-xL prevents coronavirus-induced cell death and converts acute infection to persistent infection in progenitor rat oligodendrocytes. J Virol. 2005 Jan; 79(1):47-56. PMID: 15596800.
      View in: PubMed
    27. Cai Y, Liu Y, Yu D, Zhang X. Down-regulation of transcription of the proapoptotic gene BNip3 in cultured astrocytes by murine coronavirus infection. Virology. 2003 Nov 10; 316(1):104-15. PMID: 14599795.
      View in: PubMed
    28. Liu Y, Cai Y, Zhang X. Induction of caspase-dependent apoptosis in cultured rat oligodendrocytes by murine coronavirus is mediated during cell entry and does not require virus replication. J Virol. 2003 Nov; 77(22):11952-63. PMID: 14581532.
      View in: PubMed
    29. Zhang X, Cai Y. An overview on RNA-dependent RNA polymerases of RNA viruses. RNA viruses:Mechanisms of replication and transcription (ed.:X.M. Zhang) Research Signpost(ISBN:81-271-0041-2). 2003; 1-15.
    30. Zhang X. Mechanisms of coronavirus subenomic RNA transcription. RNA viruses:Mechanisms of replication and transcription (ed.:X.M. Zhang) Research Signpost(ISBN:81-271-0041-2). 2003; 109-127.
    31. Zhang X. RNA viruses:Mechanisms of replication and transcription. (ed.:X.M. Zhang). Research Signpost (ISBN:81-271-0041-2). 2003.
    32. Popova R, Zhang X. The spike but not the hemagglutinin/esterase protein of bovine coronavirus is necessary and sufficient for viral infection. Virology. 2002 Mar 01; 294(1):222-36. PMID: 11886280.
      View in: PubMed
    33. Zhang X. Cis-acting sequences and roles of cellular proteins in regulation of coronovirus RNA synthesis. Recent Research Developments in Virology. Transworld Research Network. 2001; 131-142.
    34. Zhang X, Lyle C S, Wang Y C, Zeng L. Role of hnRNP A1 in coronavirus RNA synthesis. The Nidoviruses (Coronaviruses and Arteriviruses)(eds.:E. Lavi, S. Weiss) Plenum Press, New York. 2001; 437-446.
    35. Zhang X. Identification of a non-canonical transcription initiation site for transcription of a subgenomic mRNA of mouse hepatitis virus. The Nidoviruses (Coronaviruses and Arteriviruses)(eds.:E. Lavi, S. Weiss) Plenum Press, New York. 2001; 563-570.
    36. Zhang X. Heterogeneity of subgenomic mRNAs of a mutant mouse hepatitis virus strain JHM2c. The Nidoviruses (Coronaviruses and Arteriviruses)(eds.:E. Lavi, S. Weiss) Plenum Press, New York. 2001; 541-546.
    37. Facione NC, Katapodi M. Culture as an influence on breast cancer screening and early detection. Semin Oncol Nurs. 2000 Aug; 16(3):238-47. PMID: 10967796.
      View in: PubMed
    38. Wang Y C, Zhang X. The leader RNA of coronavirus mouse hapatitis virus contains an enhancer-like element for subgenomic mRNA transcription. J Virol. 2000; 74:10571-10580.
    39. Zhang X, Liu R Z. Identification of a non-canonical signal for transcription of a novel subgenomic mRNA of mouse hepatitis virus:Implication for the mechanism of coronavirus RNA transcription. Virology. 2000; 278:75-85.
    40. Wang Y C, Zhang X. The nucleocapsid protein of coronavirus mouse hepatitis virus interacts with the cellular heterogeneous nuclear ribonucleoprotein A1 in vitro and in vivo. Virology. 1999; 265:96-109.
    41. Zhang X, Li H P, Xue W M, Lai M M C. Formation of a ribonucleoprotein complex of mouse hepatitis virus involving heterogeneous nuclear ribonucleoprotein A1 and transcription-regulatory elements of viral RNA. Virology. 1999; 264:115-124.
    42. Zhang X, Hinton D R, Park S, Liao C L, Lai M M C, Stohlman S A. Using a defective-interfering RNA system to express the protein of mouse hepatitis virus for studying viral pathogenesis. Coronavirus and Arteriviruses(eds.:L. Enjuanes, S. Siddell and W. Spaan) Plenum Press, New York. 1998; 521-528.
    43. Zhang X, Li H P, Xue W M, Lai M M C. Cellular protein hnRNP-A1 interacts with the 3'-end and the intergenic sequence of mouse hapatitis virus negative-strand RNA to form a ribonucleoprotein complex. Coronavirus and Arteriviruses(eds.:L. Enjuanes, S. Siddell and W. Spaan) Plenum Press, New York. 1998; 227-234.
    44. Zhang X, Hinton D R, Park S, Parra B, Liao C L, Lai M M C, Stohlman S A. Expression of hemagglutinin/esterase by a mouse hepatitis virus Coronavirus defective-interfering RNA alters viral pathogenesis. Virology. 1998; 242:170-183.
    45. Li H P, Zhang X, Dancun R, Comai L, Lai M M C. Heterogeneous nuclear ribonucleoprotein A1 binds to the transcription-regulatory region of mouse hepatitis virus RNA. Proc. Natl. Acad. Sci. USA. 1997; 94:9544-9549.
    46. Zhang X, Hinton D R, Cue D, Stohlman S, Lai M M C. Expression of interferon by a coronavirus defective-interfering RNA vector and its effect on viral replication, spread and pathogenicity. Virology. 1997; 233:327-338.
    47. Zhang X, Lai M M C. A 5'-proximal RNA sequence of murine coronavirus as a potential initiation site for genomic-length mRNA transcription. J. Virol. 1996; 70:705-711.
    48. Lin Y J, Zhang X, Wu R C, Lai M M C. The 3'-untranslated region of the murine coronaviral RNA is required for subgenomic mRNA transcription. J Virol. 1996; 70:7236-7240.
    49. Zhang X, Lai M M C. Regulation of coronavirus RNA transcription is likely mediated by protein-RNA interactions. Corona and Related Viruses (eds.:P.J. Talbot and G.A. Levy) Plenum Press, New York. 1995; 515-521.
    50. Zhang X, Lai M M C. Interactions between the cytoplasmic proteins and the intergenic promoter sequence of murine hepatitis virus RNAs: Correlation with the amounts of subgenomic mRNA transcribed. J. Virol. 1995; 69:1637-1644.
    51. Liao C L, Zhang X, Lai M M C. Coronavirus defective-interfering RNA as an expression vector:the generation of a pseudo-recombinant mouse hepatitis virus expressing hemagglutinin-esterase. Virology. 1995; 208:319-327.
    52. Zhang X, C L Liao, M M C Lai. Coronavirus leader RNA regulates and initiates subgenomic mRNA transcription both in trans and in cis. J. Virol. 1994; 68:4738-4746.
    53. Lai M M C, Liao C L, Lin Y J, Zhang X. Coronavirus: How a large RNA viral genome is replicated and transcribed. Infect. Agents and Dis. 1994; 3:98-105.
    54. Zhang X, Kousoulas K G, Storz J. Comparison of the S genes and the biological properties of respiratory and enteropathogenic bovine coronaviruses. Arch Virol. 1994; 134:421-426.
    55. Zhang X, Lai M M C. Unusual heterogeneity of leader-mRNA fusion in a murine coronavirus: Implications for the mechanism of RNA transcription and recombination. J. Virol. 1994; 68:6626-6633.
    56. Zhang X, Herbst W, Kousoulas K G, Storz J. Biological and genetic characterization of a hemagglutinating coronavirus isolated from a diarrhoeic child. J. Med. Virol. 1994; 44:152-161.
    57. Storz J, Zhang X. Comparison of hemagglutinating, receptor-destroying and acetylasterase activities of avirulent and virulent bovine coronavirus strains. Arch Virol. 1992; 125:193-204.
    58. Zhang X, Kousoulas K G, Storz J. The hemagglutinin/esterase gene of human respiratory coronavirus strain OC43:Phylogenetic relationships to bovine and murine coronavirus and influenza C Virus. Virology. 1992; 186:318-323.
    59. Storz J, Herrler G, Snodgrass D, Hussain JA, Zhang X, Clark M A, Rott R. Monoclonal antibodies differentiate between hemagglutinating and receptor-destroying activities of bovine coronavirus. J. Gen. Virol. 1991; 72:2817-2820.
    60. Zhang X, Kousoulas K.G., Storz J. The hemagglutinin/esterase glocoprotein of bovine coronaviruses: Sequence and functional comparisons between virulent and avirulent stains. Virology. 1991; 185:847-852.
    61. Storz J, Zhang X. Infectious mechanisms of enteropathogenic bovine coronaviruses. Mechanisms of Pathogenicity in Infectious Diseases (Eds. F.R. Seiler, H.G. Schwick and L. Stitz) Behring Institute Communications. 1991; 89:130-137.
    62. Zhang X, Kousoulas KG, Storz J. Comparison of the nucleotide and deduced amino acid sequences specified by virulent and avirulent strains of bovine coronaviruses. Virology. 1991; 183:397-404.
    63. Herbst, W., Zhang X, Lange H., Schliesser Th. Seroprevalence of coronavirus infection in the dog in the FRG. Berl. Munch. Tierarztl. Wschr. 1988; 101:382-383.
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