 Off-Label Use
"Off-Label Use" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The practice of prescribing or using a drug outside the scope of the drug's official approved label as designated by a regulatory agency concerning the treatment of a particular disease or condition.
| Descriptor ID |
D056687
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| MeSH Number(s) |
E02.319.307.500
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| Concept/Terms |
Off-Label Use- Off-Label Use
- Off Label Use
- Off-Label Uses
- Use, Off-Label
- Uses, Off-Label
- Unlabeled Indication
- Indication, Unlabeled
- Indications, Unlabeled
- Unlabeled Indications
- Off-Label Prescribing
- Off Label Prescribing
- Off-Label Prescribings
- Prescribing, Off-Label
- Prescribings, Off-Label
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Below are MeSH descriptors whose meaning is more general than "Off-Label Use".
Below are MeSH descriptors whose meaning is more specific than "Off-Label Use".
This graph shows the total number of publications written about "Off-Label Use" by people in UAMS Profiles by year, and whether "Off-Label Use" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2024 | 1 | 0 | 1 | | 2019 | 3 | 0 | 3 | | 2017 | 2 | 2 | 4 | | 2016 | 1 | 1 | 2 | | 2015 | 0 | 1 | 1 | | 2014 | 1 | 1 | 2 | | 2013 | 2 | 0 | 2 | | 2012 | 0 | 1 | 1 | | 2010 | 1 | 1 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "Off-Label Use" by people in Profiles over the past ten years.
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Pitcher GS, Biggs JH, Dayama A, Newton DH, Tran K, Stoner MC, Smeds MR, Schermerhorn ML, Mix D. A national census for the off-label treatment of complex aortic aneurysms. J Vasc Surg. 2024 Sep; 80(3):604-611.
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C4 article: Challenges and solutions to appropriate and timely medication access in transplantation in the United States. Am J Transplant. 2020 02; 20(2):362-376.
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Zanaty M, Roa JA, Tjoumakaris SI, Jabbour P, Mouchtouris N, Sweid A, Ortega-Gutierrez S, Ishii D, Limaye K, Asi K, Samaniego EA, Hasan DM. Off-Label Use of the WEB Device. World Neurosurg. 2020 Feb; 134:e1047-e1052.
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McKinzie CJ, Chen L, Ehlert K, Grisso AG, Linafelter A, Lubsch L, O'Brien CE, Pan AC, Wright BA, Elson EC. Off-label use of intravenous antimicrobials for inhalation in patients with cystic fibrosis. Pediatr Pulmonol. 2019 11; 54 Suppl 3:S27-S45.
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Deer T, Kim P, Pope JE, Hayek S, McDowell G, Mekhail N, Diwan S, Saulino M, Moeschler S, Schultz D, Gritsenko K, Prager J, Peterson EA, Staats P, Poree L, Fishman MA, Vallejo R, Calodney A, Slavin K, de Leon Cassadala O, Levy R, Buvanendran A, Sitzman BT, Sayed D, Ferrante FM, Kloth D, Gilligan CJ, Kapural L, Kloster DR, Leong M, Rosenow JM, Lamer TJ, Stearns L. Physician Guidance on the Use of Off-Labeled Drugs in Intrathecal Drug Delivery Systems for Chronic Pain. Neuromodulation. 2019 10; 22(7):765-768.
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Mason TW, Retter A, Morgan GJ. Recombinant factor VIIa as a rescue therapy in severe haemoptysis in a patient with a Fontan circulation. Cardiol Young. 2018 Jan; 28(1):144-146.
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Gupta P, Rettiganti M, Wilcox A, Eble BK, Schmitz ML, Zakaria D. Spectrum of Off-Label Nitric Oxide Utilization After Pediatric Cardiac Surgery Among Centers of Varying Surgical Volume. J Intensive Care Med. 2019 Nov-Dec; 34(11-12):917-923.
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Goreczny S, Qureshi SA, Rosenthal E, Krasemann T, Nassar MS, Anderson DR, Morgan GJ. Comparison of self-expandable and balloon-expanding stents for hybrid ductal stenting in hypoplastic left heart complex. Cardiol Young. 2017 Jul; 27(5):837-845.
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Painter JT, Owen R, Henderson KL, Bauer MS, Mittal D, Hudson TJ. Analysis of the Appropriateness of Off-Label Antipsychotic Use for Mental Health Indications in a Veteran Population. Pharmacotherapy. 2017 Apr; 37(4):438-446.
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Shah SS, Perez G, Snelling BM, Haussen DC, Sur S, Sharma I, Yavagal DR, Elhammady MS, Peterson EC. Off-label use of the Angioseal vascular closure device for femoral arteriotomy: retrospective analysis of safety and efficacy. J Neurointerv Surg. 2017 Oct; 9(10):982-985.
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Nguyen KL, Yoshida T, Han F, Ayad I, Reemtsen BL, Salusky IB, Satou GM, Hu P, Finn JP. MRI with ferumoxytol: A single center experience of safety across the age spectrum. J Magn Reson Imaging. 2017 03; 45(3):804-812.
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