 Immunoglobulins
"Immunoglobulins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Multi-subunit proteins which function in IMMUNITY. They are produced by B LYMPHOCYTES from the IMMUNOGLOBULIN GENES. They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two light chains (IMMUNOGLOBULIN LIGHT CHAINS) with additional ancillary polypeptide chains depending on their isoforms. The variety of isoforms include monomeric or polymeric forms, and transmembrane forms (B-CELL ANTIGEN RECEPTORS) or secreted forms (ANTIBODIES). They are divided by the amino acid sequence of their heavy chains into five classes (IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M) and various subclasses.
| Descriptor ID |
D007136
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| MeSH Number(s) |
D12.776.124.486.485 D12.776.124.790.651 D12.776.377.715.548
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| Concept/Terms |
Immunoglobulins- Immunoglobulins
- Globulins, Immune
- Immune Globulins
- Immunoglobulin
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Below are MeSH descriptors whose meaning is more general than "Immunoglobulins".
Below are MeSH descriptors whose meaning is more specific than "Immunoglobulins".
This graph shows the total number of publications written about "Immunoglobulins" by people in UAMS Profiles by year, and whether "Immunoglobulins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2022 | 0 | 1 | 1 | | 2021 | 0 | 1 | 1 | | 2020 | 0 | 3 | 3 | | 2019 | 1 | 0 | 1 | | 2018 | 4 | 0 | 4 | | 2017 | 3 | 3 | 6 | | 2016 | 2 | 0 | 2 | | 2015 | 1 | 1 | 2 | | 2014 | 0 | 1 | 1 | | 2013 | 1 | 0 | 1 | | 2012 | 1 | 0 | 1 | | 2011 | 0 | 1 | 1 | | 2009 | 1 | 2 | 3 | | 2007 | 1 | 2 | 3 | | 2006 | 1 | 2 | 3 | | 2005 | 1 | 1 | 2 | | 2004 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2002 | 1 | 1 | 2 | | 2000 | 0 | 1 | 1 | | 1999 | 0 | 2 | 2 | | 1997 | 0 | 2 | 2 | | 1995 | 0 | 1 | 1 | | 1992 | 2 | 0 | 2 | | 1989 | 0 | 1 | 1 | | 1988 | 1 | 2 | 3 |
To return to the timeline, click here.
Below are the most recent publications written about "Immunoglobulins" by people in Profiles over the past ten years.
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Ebersole JL, Nagarajan R, Kirakodu SS, Gonzalez OA. Immunoglobulin gene expression profiles and microbiome characteristics in periodontitis in nonhuman primates. Mol Immunol. 2022 08; 148:18-33.
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Caro J, Cairns D, Menzies T, Boyle E, Pawlyn C, Cook G, Kaiser M, Walker BA, Owen R, Jackson GH, Morgan GJ, Heaney J, Drayson MT, Davies FE. Impact of Etiological Cytogenetic Abnormalities on the Depth of Immunoparesis and Survival in Newly Diagnosed Multiple Myeloma. Clin Lymphoma Myeloma Leuk. 2022 04; 22(4):e279-e284.
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Pal P, Ibrahim M, Niu A, Zwezdaryk KJ, Tatje E, Robinson WR, Ko L, Satyavarapu I, Jones WE, Nachabe A, Luk A, Mushatt DM, Halvorson K, Denson JL, Smith CC, Simeone F, Davis G, Gill SK, McDougal A, Vigh AS, Peterson TG, Ning B, Hu T, Socola F, Robinson J, Safah H, Saba NS. Safety and efficacy of COVID-19 convalescent plasma in severe pulmonary disease: A report of 17 patients. Transfus Med. 2021 06; 31(3):217-220.
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Dare RK. Is fulminant myocarditis caused by circulating human coronaviruses? Eur Heart J. 2020 05 14; 41(19):1854.
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Faraji E, Sukumaran S, Vijayan V. A 3 Year Old With Fever and Rash: An Atypical Cause of Shock. Clin Pediatr (Phila). 2020 06; 59(7):740-742.
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Heaney JLJ, Richter A, Bowcock S, Pratt G, Child JA, Jackson G, Morgan G, Turesson I, Drayson MT. Excluding myeloma diagnosis using revised thresholds for serum free light chain ratios and M-protein levels. Haematologica. 2020 04; 105(4):e169-e171.
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Heaney JLJ, Campbell JP, Iqbal G, Cairns D, Richter A, Child JA, Gregory W, Jackson G, Kaiser M, Owen R, Davies F, Morgan G, Dunn J, Drayson MT. Characterisation of immunoparesis in newly diagnosed myeloma and its impact on progression-free and overall survival in both old and recent myeloma trials. Leukemia. 2018 08; 32(8):1727-1738.
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Hintermann E, Bayer M, Conti CB, Fuchs S, Fausther M, Leung PS, Aurrand-Lions M, Taubert R, Pfeilschifter JM, Friedrich-Rust M, Schuppan D, Dranoff JA, Gershwin ME, Manns MP, Imhof BA, Christen U. Junctional adhesion molecules JAM-B and JAM-C promote autoimmune-mediated liver fibrosis in mice. J Autoimmun. 2018 07; 91:83-96.
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Alapat D. Cytoplasmic Immunoglobulin Vs. DNA Analysis by Flow Cytometry. Methods Mol Biol. 2018; 1792:35-45.
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Walker BA. Whole Exome Sequencing in Multiple Myeloma to Identify Somatic Single Nucleotide Variants and Key Translocations Involving Immunoglobulin Loci and MYC. Methods Mol Biol. 2018; 1792:71-95.
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Post GR, Guillory E, Wade CL, LeSourd SE, Post SR. Effect of Serum Immunoglobulins on Routine Coagulation Tests: A Comparison of Coagulation Analyzers using Mechanical and Optical Clot Detection. Ann Clin Lab Sci. 2017 Nov; 47(6):744-746.
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Palatnik A, Ye S, Kendziorski C, Iden M, Zigman JS, Hessner MJ, Rader JS. Identification of a serum-induced transcriptional signature associated with metastatic cervical cancer. PLoS One. 2017; 12(8):e0181242.
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Pawlyn C, Morgan GJ. Evolutionary biology of high-risk multiple myeloma. Nat Rev Cancer. 2017 08 24; 17(9):543-556.
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Heaney JLJ, Campbell JP, Griffin AE, Birtwistle J, Shemar M, Child JA, Gregory WM, Cairns DA, Morgan G, Jackson G, Drayson MT. Diagnosis and monitoring for light chain only and oligosecretory myeloma using serum free light chain tests. Br J Haematol. 2017 07; 178(2):220-230.
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Wagner-Johnston ND, Lensing S, Noy A, Ratner L, Henry D, Lee JY, Silver S, Faham M, Ambinder RF. High frequency of identical clonal immunoglobulin DNA in pre-treatment tumor and plasma from untreated patients with HIV-associated lymphoma: prospective multicenter trial of the AIDS malignancies consortium (AMC 064). Leuk Lymphoma. 2017 12; 58(12):2939-2942.
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Sierakowski J, Arthur J, Wylie T. Acute Hypotonia in an Infant. J Emerg Med. 2017 Jun; 52(6):e245-e247.
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Perez EE, Orange JS, Bonilla F, Chinen J, Chinn IK, Dorsey M, El-Gamal Y, Harville TO, Hossny E, Mazer B, Nelson R, Secord E, Jordan SC, Stiehm ER, Vo AA, Ballow M. Update on the use of immunoglobulin in human disease: A review of evidence. J Allergy Clin Immunol. 2017 Mar; 139(3S):S1-S46.
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Papanikolaou X, Rosenthal A, Dhodapkar M, Epstein J, Khan R, van Rhee F, Jethava Y, Waheed S, Zangari M, Hoering A, Crowley J, Alapat D, Davies F, Morgan G, Barlogie B. Flow cytometry defined cytoplasmic immunoglobulin index is a major prognostic factor for progression of asymptomatic monoclonal gammopathies to multiple myeloma (subset analysis of SWOG S0120). Blood Cancer J. 2016 Mar 25; 6:e410.
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Prueitt RL, Wallace TA, Glynn SA, Yi M, Tang W, Luo J, Dorsey TH, Stagliano KE, Gillespie JW, Hudson RS, Terunuma A, Shoe JL, Haines DC, Yfantis HG, Han M, Martin DN, Jordan SV, Borin JF, Naslund MJ, Alexander RB, Stephens RM, Loffredo CA, Lee DH, Putluri N, Sreekumar A, Hurwitz AA, Ambs S. An Immune-Inflammation Gene Expression Signature in Prostate Tumors of Smokers. Cancer Res. 2016 Mar 01; 76(5):1055-1065.
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Larsen CP, Messias NC, Walker PD, Fidler ME, Cornell LD, Hernandez LH, Alexander MP, Sethi S, Nasr SH. Membranoproliferative glomerulonephritis with masked monotypic immunoglobulin deposits. Kidney Int. 2015 Oct; 88(4):867-73.
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Fernández de Larrea C, Delforge M, Davies F, Bladé J. Response evaluation and monitoring of multiple myeloma. Expert Rev Hematol. 2014 Feb; 7(1):33-42.
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Zhang L, Fok JJ, Mirabella F, Aronson LI, Fryer RA, Workman P, Morgan GJ, Davies FE. Hsp70 inhibition induces myeloma cell death via the intracellular accumulation of immunoglobulin and the generation of proteotoxic stress. Cancer Lett. 2013 Oct 01; 339(1):49-59.
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