 Comet Assay
"Comet Assay" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A genotoxicological technique for measuring DNA damage in an individual cell using single-cell gel electrophoresis. Cell DNA fragments assume a "comet with tail" formation on electrophoresis and are detected with an image analysis system. Alkaline assay conditions facilitate sensitive detection of single-strand damage.
| Descriptor ID |
D020552
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| MeSH Number(s) |
E05.196.401.153.150 E05.301.300.100.150 E05.393.560.150 E05.940.560.150
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| Concept/Terms |
Comet Assay- Comet Assay
- Assay, Comet
- Assays, Comet
- Comet Assays
- Gel Electrophoresis, Single-Cell
- Electrophoreses, Single-Cell Gel
- Electrophoresis, Single-Cell Gel
- Gel Electrophoreses, Single-Cell
- Gel Electrophoresis, Single Cell
- Single-Cell Gel Electrophoreses
- Single-Cell Gel Electrophoresis
- Electrophoresis, Gel, Single-Cell
Alkaline Comet Assay- Alkaline Comet Assay
- Alkaline Comet Assays
- Assay, Alkaline Comet
- Assays, Alkaline Comet
- Comet Assay, Alkaline
- Comet Assays, Alkaline
- Alkaline Single-Cell Gel Electrophoresis Assay
- Alkaline Single Cell Gel Electrophoresis Assay
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Below are MeSH descriptors whose meaning is more general than "Comet Assay".
Below are MeSH descriptors whose meaning is more specific than "Comet Assay".
This graph shows the total number of publications written about "Comet Assay" by people in UAMS Profiles by year, and whether "Comet Assay" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2020 | 0 | 1 | 1 | | 2019 | 1 | 0 | 1 | | 2016 | 1 | 1 | 2 | | 2015 | 0 | 1 | 1 | | 2014 | 0 | 2 | 2 | | 2013 | 0 | 2 | 2 | | 2012 | 1 | 0 | 1 | | 2010 | 0 | 1 | 1 | | 2009 | 1 | 0 | 1 | | 2008 | 0 | 1 | 1 | | 2006 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2004 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Comet Assay" by people in Profiles over the past ten years.
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Demir E, Qin T, Li Y, Zhang Y, Guo X, Ingle T, Yan J, Orza AI, Biris AS, Ghorai S, Zhou T, Chen T. Cytotoxicity and genotoxicity of cadmium oxide nanoparticles evaluated using in vitro assays. Mutat Res Genet Toxicol Environ Mutagen. 2020 Feb - Mar; 850-851:503149.
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Seo JE, Tryndyak V, Wu Q, Dreval K, Pogribny I, Bryant M, Zhou T, Robison TW, Mei N, Guo X. Quantitative comparison of in vitro genotoxicity between metabolically competent HepaRG cells and HepG2 cells using the high-throughput high-content CometChip assay. Arch Toxicol. 2019 05; 93(5):1433-1448.
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Imanikia S, Galea F, Nagy E, Phillips DH, Stürzenbaum SR, Arlt VM. The application of the comet assay to assess the genotoxicity of environmental pollutants in the nematode Caenorhabditis elegans. Environ Toxicol Pharmacol. 2016 Jul; 45:356-61.
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Sogbanmu TO, Nagy E, Phillips DH, Arlt VM, Otitoloju AA, Bury NR. Lagos lagoon sediment organic extracts and polycyclic aromatic hydrocarbons induce embryotoxic, teratogenic and genotoxic effects in Danio rerio (zebrafish) embryos. Environ Sci Pollut Res Int. 2016 Jul; 23(14):14489-501.
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Dai L, Trillo-Tinoco J, Cao Y, Bonstaff K, Doyle L, Del Valle L, Whitby D, Parsons C, Reiss K, Zabaleta J, Qin Z. Targeting HGF/c-MET induces cell cycle arrest, DNA damage, and apoptosis for primary effusion lymphoma. Blood. 2015 Dec 24; 126(26):2821-31.
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Ding W, Levy DD, Bishop ME, Pearce MG, Davis KJ, Jeffrey AM, Duan JD, Williams GM, White GA, Lyn-Cook LE, Manjanatha MG. In vivo genotoxicity of estragole in male F344 rats. Environ Mol Mutagen. 2015 May; 56(4):356-65.
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Godschalk RW, Ersson C, Stepnik M, Ferlinska M, Palus J, Teixeira JP, Costa S, Jones GD, Higgins JA, Kain J, Möller L, Forchhammer L, Loft S, Lorenzo Y, Collins AR, van Schooten FJ, Laffon B, Valdiglesias V, Cooke M, Mistry V, Karbaschi M, Phillips DH, Sozeri O, Routledge MN, Nelson-Smith K, Riso P, Porrini M, López de Cerain A, Azqueta A, Matullo G, Allione A, Møller P. Variation of DNA damage levels in peripheral blood mononuclear cells isolated in different laboratories. Mutagenesis. 2014 Jul; 29(4):241-9.
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Lin H, Guo X, Zhang S, Dial SL, Guo L, Manjanatha MG, Moore MM, Mei N. Mechanistic evaluation of Ginkgo biloba leaf extract-induced genotoxicity in L5178Y cells. Toxicol Sci. 2014 Jun; 139(2):338-49.
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Ali R, Guo X, Lin H, Khan QM, Ismail M, Waheed U, Ali T, Bhalli JA. Mutant frequency in comparison to oxidative DNA damage induced by ochratoxin A in L5178Y tk+/- (3.7.2C) mouse lymphoma cells. Drug Chem Toxicol. 2014 Apr; 37(2):227-32.
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Aher V, Chattopadhyay P, Goyary D, Veer V. Evaluation of the genotoxic and antigenotoxic potential of the alkaloid punarnavine from Boerhaavia diffusa. Planta Med. 2013 Jul; 79(11):939-45.
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Mehdi SH, Qamar A. Paraquat-induced ultrastructural changes and DNA damage in the nervous system is mediated via oxidative-stress-induced cytotoxicity in Drosophila melanogaster. Toxicol Sci. 2013 Aug; 134(2):355-65.
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Sousa MM, Zub KA, Aas PA, Hanssen-Bauer A, Demirovic A, Sarno A, Tian E, Liabakk NB, Slupphaug G. An inverse switch in DNA base excision and strand break repair contributes to melphalan resistance in multiple myeloma cells. PLoS One. 2013; 8(2):e55493.
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