 Carcinoma, Merkel Cell
"Carcinoma, Merkel Cell" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A carcinoma arising from MERKEL CELLS located in the basal layer of the epidermis and occurring most commonly as a primary neuroendocrine carcinoma of the skin. Merkel cells are tactile cells of neuroectodermal origin and histologically show neurosecretory granules. The skin of the head and neck are a common site of Merkel cell carcinoma, occurring generally in elderly patients. (Holland et al., Cancer Medicine, 3d ed, p1245)
| Descriptor ID |
D015266
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| MeSH Number(s) |
C02.256.721.150 C02.928.216 C04.557.465.625.650.240.325 C04.557.470.200.025.370.325 C04.557.580.625.650.240.325 C04.925.216
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| Concept/Terms |
Carcinoma, Merkel Cell- Carcinoma, Merkel Cell
- Merkel Cell Carcinoma
- Merkle Tumors
- Tumors, Merkle
- Merkel Cell Cancer
- Cancer, Merkel Cell
- Cell Cancer, Merkel
- Merkel Cell Tumor
- Tumor, Merkel Cell
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Below are MeSH descriptors whose meaning is more general than "Carcinoma, Merkel Cell".
- Diseases [C]
- Virus Diseases [C02]
- DNA Virus Infections [C02.256]
- Polyomavirus Infections [C02.256.721]
- Carcinoma, Merkel Cell [C02.256.721.150]
- Tumor Virus Infections [C02.928]
- Carcinoma, Merkel Cell [C02.928.216]
- Neoplasms [C04]
- Neoplasms by Histologic Type [C04.557]
- Neoplasms, Germ Cell and Embryonal [C04.557.465]
- Neuroectodermal Tumors [C04.557.465.625]
- Neuroendocrine Tumors [C04.557.465.625.650]
- Carcinoma, Neuroendocrine [C04.557.465.625.650.240]
- Carcinoma, Merkel Cell [C04.557.465.625.650.240.325]
- Neoplasms, Glandular and Epithelial [C04.557.470]
- Carcinoma [C04.557.470.200]
- Adenocarcinoma [C04.557.470.200.025]
- Carcinoma, Neuroendocrine [C04.557.470.200.025.370]
- Carcinoma, Merkel Cell [C04.557.470.200.025.370.325]
- Neoplasms, Nerve Tissue [C04.557.580]
- Neuroectodermal Tumors [C04.557.580.625]
- Neuroendocrine Tumors [C04.557.580.625.650]
- Carcinoma, Neuroendocrine [C04.557.580.625.650.240]
- Carcinoma, Merkel Cell [C04.557.580.625.650.240.325]
- Tumor Virus Infections [C04.925]
- Carcinoma, Merkel Cell [C04.925.216]
Below are MeSH descriptors whose meaning is more specific than "Carcinoma, Merkel Cell".
This graph shows the total number of publications written about "Carcinoma, Merkel Cell" by people in UAMS Profiles by year, and whether "Carcinoma, Merkel Cell" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2022 | 0 | 1 | 1 | | 2020 | 1 | 0 | 1 | | 2019 | 1 | 0 | 1 | | 2017 | 1 | 0 | 1 | | 2016 | 2 | 0 | 2 | | 2015 | 2 | 0 | 2 | | 2014 | 3 | 0 | 3 | | 2013 | 1 | 0 | 1 | | 2012 | 1 | 0 | 1 | | 2010 | 2 | 0 | 2 | | 2009 | 1 | 0 | 1 | | 2006 | 1 | 0 | 1 | | 2004 | 1 | 0 | 1 | | 2001 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Carcinoma, Merkel Cell" by people in Profiles over the past ten years.
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Lindsey MS, Bridge JA, Douglas DS, Foster JT, Shalin SC, Gardner JM. Primary Cutaneous Alveolar Rhabdomyosarcoma in an Elderly Adult: A Rare Potential Mimic of Merkel Cell Carcinoma. Am J Dermatopathol. 2022 Mar 01; 44(3):218-222.
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Fang B, Kannan A, Zhao S, Nguyen QH, Ejadi S, Yamamoto M, Camilo Barreto J, Zhao H, Gao L. Inhibition of PI3K by copanlisib exerts potent antitumor effects on Merkel cell carcinoma cell lines and mouse xenografts. Sci Rep. 2020 06 01; 10(1):8867.
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Zoumberos NA, McMullen E, Wang L, Wang X, Harms KL, Tejasvi T, Chan MP, Fullen DR, Hristov AC, Harms PW. Merkel cell carcinoma arising in association with cutaneous T-cell lymphoma: A potential diagnostic pitfall. J Cutan Pathol. 2019 Mar; 46(3):199-203.
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Garrett GL, Blanc PD, Boscardin J, Lloyd AA, Ahmed RL, Anthony T, Bibee K, Breithaupt A, Cannon J, Chen A, Cheng JY, Chiesa-Fuxench Z, Colegio OR, Curiel-Lewandrowski C, Del Guzzo CA, Disse M, Dowd M, Eilers R, Ortiz AE, Morris C, Golden SK, Graves MS, Griffin JR, Hopkins RS, Huang CC, Bae GH, Jambusaria A, Jennings TA, Jiang SI, Karia PS, Khetarpal S, Kim C, Klintmalm G, Konicke K, Koyfman SA, Lam C, Lee P, Leitenberger JJ, Loh T, Lowenstein S, Madankumar R, Moreau JF, Nijhawan RI, Ochoa S, Olasz EB, Otchere E, Otley C, Oulton J, Patel PH, Patel VA, Prabhu AV, Pugliano-Mauro M, Schmults CD, Schram S, Shih AF, Shin T, Soon S, Soriano T, Srivastava D, Stein JA, Sternhell-Blackwell K, Taylor S, Vidimos A, Wu P, Zajdel N, Zelac D, Arron ST. Incidence of and Risk Factors for Skin Cancer in Organ Transplant Recipients in the United States. JAMA Dermatol. 2017 03 01; 153(3):296-303.
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Kannan A, Lin Z, Shao Q, Zhao S, Fang B, Moreno MA, Vural E, Stack BC, Suen JY, Kannan K, Gao L. Dual mTOR inhibitor MLN0128 suppresses Merkel cell carcinoma (MCC) xenograft tumor growth. Oncotarget. 2016 Feb 09; 7(6):6576-92.
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Shiver MB, Mahmoud F, Gao L. More on Merkel-Cell Carcinoma. N Engl J Med. 2016 02 04; 374(5):495.
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Shiver MB, Mahmoud F, Gao L. Response to Idelalisib in a Patient with Stage IV Merkel-Cell Carcinoma. N Engl J Med. 2015 Oct 15; 373(16):1580-2.
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Sengupta D, Kannan A, Kern M, Moreno MA, Vural E, Stack B, Suen JY, Tackett AJ, Gao L. Disruption of BRD4 at H3K27Ac-enriched enhancer region correlates with decreased c-Myc expression in Merkel cell carcinoma. Epigenetics. 2015; 10(6):460-6.
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Sexton KW, Poteet SP, Hill JB, Schmidt A, Patel A, Del Corral GA, Axt J, Kelley MC, Thayer WP, Shack RB. Adjuvant radiation therapy increases disease-free survival in stage IB Merkel cell carcinoma. Ann Plast Surg. 2014 Nov; 73(5):531-4.
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Shalin SC, Cifarelli CP, Suen JY, Gao L. Loss of cytokeratin 20 and acquisition of thyroid transcription factor-1 expression in a merkel cell carcinoma metastasis to the brain. Am J Dermatopathol. 2014 Nov; 36(11):904-6.
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Shao Q, Kannan A, Lin Z, Stack BC, Suen JY, Gao L. BET protein inhibitor JQ1 attenuates Myc-amplified MCC tumor growth in vivo. Cancer Res. 2014 Dec 01; 74(23):7090-102.
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Lin Z, McDermott A, Shao L, Kannan A, Morgan M, Stack BC, Moreno M, Davis DA, Cornelius LA, Gao L. Chronic mTOR activation promotes cell survival in Merkel cell carcinoma. Cancer Lett. 2014 Mar 28; 344(2):272-281.
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