 Thapsigargin
"Thapsigargin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A sesquiterpene lactone found in roots of THAPSIA. It inhibits CA(2+)-TRANSPORTING ATPASE mediated uptake of CALCIUM into SARCOPLASMIC RETICULUM.
| Descriptor ID |
D019284
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| MeSH Number(s) |
D02.455.426.392.368.284.500.888 D02.455.849.765.793.888
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Thapsigargin".
Below are MeSH descriptors whose meaning is more specific than "Thapsigargin".
This graph shows the total number of publications written about "Thapsigargin" by people in UAMS Profiles by year, and whether "Thapsigargin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2021 | 1 | 0 | 1 | | 2014 | 0 | 2 | 2 | | 2012 | 0 | 1 | 1 | | 2010 | 0 | 1 | 1 | | 2008 | 0 | 1 | 1 | | 2007 | 0 | 1 | 1 | | 1995 | 0 | 1 | 1 | | 1994 | 0 | 1 | 1 |
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Below are the most recent publications written about "Thapsigargin" by people in Profiles over the past ten years.
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Al-Beltagi S, Goulding LV, Chang DKE, Mellits KH, Hayes CJ, Gershkovich P, Coleman CM, Chang KC. Emergent SARS-CoV-2 variants: comparative replication dynamics and high sensitivity to thapsigargin. Virulence. 2021 12; 12(1):2946-2956.
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Cooley CB, Ryno LM, Plate L, Morgan GJ, Hulleman JD, Kelly JW, Wiseman RL. Unfolded protein response activation reduces secretion and extracellular aggregation of amyloidogenic immunoglobulin light chain. Proc Natl Acad Sci U S A. 2014 Sep 09; 111(36):13046-51.
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Godbole AM, Ramalingam S, Ramamurthy VP, Khandelwal A, Bruno RD, Upreti VV, Gediya LK, Purushottamachar P, Mbatia HW, Addya S, Ambulos N, Njar VC. VN/14-1 induces ER stress and autophagy in HP-LTLC human breast cancer cells and has excellent oral pharmacokinetic profile in female Sprague Dawley rats. Eur J Pharmacol. 2014 Jul 05; 734:98-104.
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