 Glucuronosyltransferase
"Glucuronosyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines, and fatty acids. They function as drug-metabolizing enzymes that catalyze the conjugation of UDPglucuronic acid to a variety of endogenous and exogenous compounds. EC 2.4.1.17.
| Descriptor ID |
D014453
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| MeSH Number(s) |
D08.811.913.400.450.480
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| Concept/Terms |
Glucuronosyltransferase- Glucuronosyltransferase
- Glucuronyltransferase
- UDP Glucuronyl Transferase
- Glucuronyl Transferase, UDP
- Transferase, UDP Glucuronyl
- Glucuronic Transferase
- Transferase, Glucuronic
- UDP Glucuronosyltransferase
- Glucuronosyltransferase, UDP
7-Hydroxycoumarin UDP Glucuronyltransferase- 7-Hydroxycoumarin UDP Glucuronyltransferase
- 7 Hydroxycoumarin UDP Glucuronyltransferase
- Glucuronyltransferase, 7-Hydroxycoumarin UDP
- UDP Glucuronyltransferase, 7-Hydroxycoumarin
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Below are MeSH descriptors whose meaning is more general than "Glucuronosyltransferase".
Below are MeSH descriptors whose meaning is more specific than "Glucuronosyltransferase".
This graph shows the total number of publications written about "Glucuronosyltransferase" by people in UAMS Profiles by year, and whether "Glucuronosyltransferase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2019 | 1 | 3 | 4 | | 2018 | 0 | 1 | 1 | | 2017 | 3 | 2 | 5 | | 2016 | 2 | 1 | 3 | | 2015 | 5 | 2 | 7 | | 2014 | 6 | 0 | 6 | | 2013 | 4 | 0 | 4 | | 2012 | 3 | 1 | 4 | | 2011 | 7 | 1 | 8 | | 2010 | 6 | 2 | 8 | | 2009 | 6 | 0 | 6 | | 2008 | 6 | 0 | 6 | | 2007 | 11 | 0 | 11 | | 2006 | 4 | 1 | 5 | | 2005 | 5 | 0 | 5 | | 2004 | 3 | 0 | 3 | | 2003 | 3 | 1 | 4 | | 2002 | 3 | 0 | 3 | | 2001 | 3 | 1 | 4 | | 2000 | 4 | 0 | 4 | | 1999 | 7 | 0 | 7 | | 1998 | 4 | 0 | 4 |
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Below are the most recent publications written about "Glucuronosyltransferase" by people in Profiles over the past ten years.
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Matlock MK, Tambe A, Elliott-Higgins J, Hines RN, Miller GP, Swamidass SJ. A Time-Embedding Network Models the Ontogeny of 23 Hepatic Drug Metabolizing Enzymes. Chem Res Toxicol. 2019 08 19; 32(8):1707-1721.
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Kennon-McGill S, Clemens MM, McGill MR. Expression of drug metabolizing enzymes and transporters in the cochlea: Implications for drug delivery and ototoxicity. Hear Res. 2019 08; 379:98-102.
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Jones S, Yarbrough AL, Shoeib A, Bush JM, Fantegrossi WE, Prather PL, Radominska-Pandya A, Fujiwara R. Enzymatic analysis of glucuronidation of synthetic cannabinoid 1-naphthyl 1-(4-fluorobenzyl)-1H-indole-3-carboxylate (FDU-PB-22). Xenobiotica. 2019 Dec; 49(12):1388-1395.
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Kazuki Y, Kobayashi K, Hirabayashi M, Abe S, Kajitani N, Kazuki K, Takehara S, Takiguchi M, Satoh D, Kuze J, Sakuma T, Kaneko T, Mashimo T, Osamura M, Hashimoto M, Wakatsuki R, Hirashima R, Fujiwara R, Deguchi T, Kurihara A, Tsukazaki Y, Senda N, Yamamoto T, Scheer N, Oshimura M. Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism. Proc Natl Acad Sci U S A. 2019 02 19; 116(8):3072-3081.
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Kim SY, Jones DR, Kang JY, Yun CH, Miller GP. Regioselectivity significantly impacts microsomal glucuronidation efficiency of R/S-6, 7-, and 8-hydroxywarfarin. Xenobiotica. 2019 Apr; 49(4):397-403.
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Fujiwara R, Yoda E, Tukey RH. Species differences in drug glucuronidation: Humanized UDP-glucuronosyltransferase 1 mice and their application for predicting drug glucuronidation and drug-induced toxicity in humans. Drug Metab Pharmacokinet. 2018 Feb; 33(1):9-16.
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Court MH, Zhu Z, Masse G, Duan SX, James LP, Harmatz JS, Greenblatt DJ. Race, Gender, and Genetic Polymorphism Contribute to Variability in Acetaminophen Pharmacokinetics, Metabolism, and Protein-Adduct Concentrations in Healthy African-American and European-American Volunteers. J Pharmacol Exp Ther. 2017 09; 362(3):431-440.
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Koyama M, Shirahata T, Hirashima R, Kobayashi Y, Itoh T, Fujiwara R. Inhibition of UDP-glucuronosyltransferase (UGT)-mediated glycyrrhetinic acid 3-O-glucuronidation by polyphenols and triterpenoids. Drug Metab Pharmacokinet. 2017 Aug; 32(4):218-223.
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Yoda E, Paszek M, Konopnicki C, Fujiwara R, Chen S, Tukey RH. Isothiocyanates induce UGT1A1 in humanized UGT1 mice in a CAR dependent fashion that is highly dependent upon oxidative stress. Sci Rep. 2017 04 19; 7:46489.
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Redan BW, Albaugh GP, Charron CS, Novotny JA, Ferruzzi MG. Adaptation in Caco-2 Human Intestinal Cell Differentiation and Phenolic Transport with Chronic Exposure to Blackberry (Rubus sp.) Extract. J Agric Food Chem. 2017 Apr 05; 65(13):2694-2701.
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Hirashima R, Michimae H, Takemoto H, Sasaki A, Kobayashi Y, Itoh T, Tukey RH, Fujiwara R. Induction of the UDP-Glucuronosyltransferase 1A1 during the Perinatal Period Can Cause Neurodevelopmental Toxicity. Mol Pharmacol. 2016 09; 90(3):265-74.
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Liu M, Chen S, Yueh MF, Fujiwara R, Konopnicki C, Hao H, Tukey RH. Cadmium and arsenic override NF-?B developmental regulation of the intestinal UGT1A1 gene and control of hyperbilirubinemia. Biochem Pharmacol. 2016 06 15; 110-111:37-46.
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Mitsugi R, Sumida K, Fujie Y, Tukey RH, Itoh T, Fujiwara R. Acyl-glucuronide as a Possible Cause of Trovafloxacin-Induced Liver Toxicity: Induction of Chemokine (C-X-C Motif) Ligand 2 by Trovafloxacin Acyl-glucuronide. Biol Pharm Bull. 2016; 39(10):1604-1610.
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Fujiwara R, Maruo Y, Chen S, Tukey RH. Role of extrahepatic UDP-glucuronosyltransferase 1A1: Advances in understanding breast milk-induced neonatal hyperbilirubinemia. Toxicol Appl Pharmacol. 2015 Nov 15; 289(1):124-32.
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Mitsugi R, Itoh T, Fujiwara R. Expression of Human DNAJ (Heat Shock Protein-40) B3 in Humanized UDP-glucuronosyltransferase 1 Mice. Int J Mol Sci. 2015 Jul 02; 16(7):14997-5008.
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Takagi M, Sakamoto M, Itoh T, Fujiwara R. Underlying mechanism of drug-drug interaction between pioglitazone and gemfibrozil: Gemfibrozil acyl-glucuronide is a mechanism-based inhibitor of CYP2C8. Drug Metab Pharmacokinet. 2015 Aug; 30(4):288-94.
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Sakamoto M, Itoh T, Tukey RH, Fujiwara R. Nicotine regulates the expression of UDP-glucuronosyltransferase (UGT) in humanized UGT1 mouse brain. Drug Metab Pharmacokinet. 2015 Aug; 30(4):269-75.
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Oda S, Fujiwara R, Kutsuno Y, Fukami T, Itoh T, Yokoi T, Nakajima M. Targeted screen for human UDP-glucuronosyltransferases inhibitors and the evaluation of potential drug-drug interactions with zafirlukast. Drug Metab Dispos. 2015 Jun; 43(6):812-8.
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Dai L, Chen Y, Bonstaff K, Doyle L, Toole B, Parsons C, Qin Z. Induction of hyaluronan production by oncogenic KSHV and the contribution to viral pathogenesis in AIDS patients. Cancer Lett. 2015 Jul 01; 362(2):158-66.
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Dates CR, Fahmi T, Pyrek SJ, Yao-Borengasser A, Borowa-Mazgaj B, Bratton SM, Kadlubar SA, Mackenzie PI, Haun RS, Radominska-Pandya A. Human UDP-Glucuronosyltransferases: Effects of altered expression in breast and pancreatic cancer cell lines. Cancer Biol Ther. 2015; 16(5):714-23.
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Pugh CP, Pouncey DL, Hartman JH, Nshimiyimana R, Desrochers LP, Goodwin TE, Boysen G, Miller GP. Multiple UDP-glucuronosyltransferases in human liver microsomes glucuronidate both R- and S-7-hydroxywarfarin into two metabolites. Arch Biochem Biophys. 2014 Dec 15; 564:244-53.
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Fujiwara R, Sumida K, Kutsuno Y, Sakamoto M, Itoh T. UDP-glucuronosyltransferase (UGT) 1A1 mainly contributes to the glucuronidation of trovafloxacin. Drug Metab Pharmacokinet. 2015 Feb; 30(1):82-8.
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Aoshima N, Fujie Y, Itoh T, Tukey RH, Fujiwara R. Glucose induces intestinal human UDP-glucuronosyltransferase (UGT) 1A1 to prevent neonatal hyperbilirubinemia. Sci Rep. 2014 Sep 11; 4:6343.
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Greer AK, Dates CR, Starlard-Davenport A, Edavana VK, Bratton SM, Dhakal IB, Finel M, Kadlubar SA, Radominska-Pandya A. A potential role for human UDP-glucuronosyltransferase 1A4 promoter single nucleotide polymorphisms in the pharmacogenomics of tamoxifen and its derivatives. Drug Metab Dispos. 2014 Sep; 42(9):1392-400.
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Kutsuno Y, Itoh T, Tukey RH, Fujiwara R. Glucuronidation of drugs and drug-induced toxicity in humanized UDP-glucuronosyltransferase 1 mice. Drug Metab Dispos. 2014 Jul; 42(7):1146-52.
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Greer AK, Madadi NR, Bratton SM, Eddy SD, Mazerska Z, Hendrickson HP, Crooks PA, Radominska-Pandya A. Novel resveratrol-based substrates for human hepatic, renal, and intestinal UDP-glucuronosyltransferases. Chem Res Toxicol. 2014 Apr 21; 27(4):536-45.
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Fujiwara R, Itoh T. Extensive protein-protein interactions involving UDP-glucuronosyltransferase (UGT) 2B7 in human liver microsomes. Drug Metab Pharmacokinet. 2014; 29(3):259-65.
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Shibuya A, Itoh T, Tukey RH, Fujiwara R. Impact of fatty acids on human UDP-glucuronosyltransferase 1A1 activity and its expression in neonatal hyperbilirubinemia. Sci Rep. 2013 Oct 09; 3:2903.
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Sumida K, Kawana M, Kouno E, Itoh T, Takano S, Narawa T, Tukey RH, Fujiwara R. Importance of UDP-glucuronosyltransferase 1A1 expression in skin and its induction by UVB in neonatal hyperbilirubinemia. Mol Pharmacol. 2013 Nov; 84(5):679-86.
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Edavana VK, Dhakal IB, Williams S, Penney R, Boysen G, Yao-Borengasser A, Kadlubar S. Potential role of UGT1A4 promoter SNPs in anastrozole pharmacogenomics. Drug Metab Dispos. 2013 Apr; 41(4):870-7.
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Fukuda T, Goebel J, Cox S, Maseck D, Zhang K, Sherbotie JR, Ellis EN, James LP, Ward RM, Vinks AA. UGT1A9, UGT2B7, and MRP2 genotypes can predict mycophenolic acid pharmacokinetic variability in pediatric kidney transplant recipients. Ther Drug Monit. 2012 Dec; 34(6):671-9.
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Pawlowska M, Chu R, Fedejko-Kap B, Augustin E, Mazerska Z, Radominska-Pandya A, Chambers TC. Metabolic transformation of antitumor acridinone C-1305 but not C-1311 via selective cellular expression of UGT1A10 increases cytotoxic response: implications for clinical use. Drug Metab Dispos. 2013 Feb; 41(2):414-21.
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