 Hydroxymethylglutaryl-CoA Reductase Inhibitors
"Hydroxymethylglutaryl-CoA Reductase Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Compounds that inhibit HMG-CoA reductases. They have been shown to directly lower cholesterol synthesis.
| Descriptor ID |
D019161
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| MeSH Number(s) |
D27.505.519.186.071.202.370 D27.505.519.389.370 D27.505.954.557.500.202.370
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| Concept/Terms |
Hydroxymethylglutaryl-CoA Reductase Inhibitors- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Hydroxymethylglutaryl CoA Reductase Inhibitors
- Inhibitors, Hydroxymethylglutaryl-CoA Reductase
- Reductase Inhibitors, Hydroxymethylglutaryl-CoA
- Statins, HMG-CoA
- HMG-CoA Statins
- Statins, HMG CoA
- Inhibitors, Hydroxymethylglutaryl-CoA
- Hydroxymethylglutaryl-CoA Inhibitors
- Inhibitors, Hydroxymethylglutaryl CoA
- Inhibitors, Hydroxymethylglutaryl-Coenzyme A
- Hydroxymethylglutaryl-Coenzyme A Inhibitors
- Inhibitors, Hydroxymethylglutaryl Coenzyme A
- HMG-CoA Reductase Inhibitors
- HMG CoA Reductase Inhibitors
- Reductase Inhibitors, HMG-CoA
- Inhibitors, HMG-CoA Reductase
- Inhibitors, HMG CoA Reductase
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Below are MeSH descriptors whose meaning is more general than "Hydroxymethylglutaryl-CoA Reductase Inhibitors".
Below are MeSH descriptors whose meaning is more specific than "Hydroxymethylglutaryl-CoA Reductase Inhibitors".
This graph shows the total number of publications written about "Hydroxymethylglutaryl-CoA Reductase Inhibitors" by people in UAMS Profiles by year, and whether "Hydroxymethylglutaryl-CoA Reductase Inhibitors" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2022 | 2 | 0 | 2 | | 2021 | 2 | 0 | 2 | | 2020 | 3 | 0 | 3 | | 2019 | 1 | 1 | 2 | | 2018 | 2 | 0 | 2 | | 2017 | 1 | 0 | 1 | | 2016 | 4 | 2 | 6 | | 2015 | 3 | 3 | 6 | | 2014 | 4 | 0 | 4 | | 2013 | 3 | 2 | 5 | | 2012 | 4 | 1 | 5 | | 2011 | 2 | 0 | 2 | | 2010 | 3 | 2 | 5 | | 2009 | 7 | 3 | 10 | | 2008 | 8 | 0 | 8 | | 2007 | 6 | 1 | 7 | | 2006 | 7 | 5 | 12 | | 2005 | 6 | 3 | 9 | | 2004 | 3 | 2 | 5 | | 2003 | 4 | 2 | 6 | | 2002 | 3 | 1 | 4 | | 2001 | 1 | 0 | 1 | | 1991 | 1 | 0 | 1 |
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Below are the most recent publications written about "Hydroxymethylglutaryl-CoA Reductase Inhibitors" by people in Profiles over the past ten years.
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Hunt CM, Efird JT, Redding TS, Thompson AD, Press AM, Williams CD, Hostler CJ, Suzuki A. Medications Associated with Lower Mortality in a SARS-CoV-2 Positive Cohort of 26,508 Veterans. J Gen Intern Med. 2022 12; 37(16):4144-4152.
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Ye R, Jneid H, Alam M, Uretsky BF, Atar D, Kitakaze M, Davidson SM, Yellon DM, Birnbaum Y. Do We Really Need Aspirin Loading for STEMI? Cardiovasc Drugs Ther. 2022 12; 36(6):1221-1238.
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Skajaa N, Bakos I, Horváth-Puhó E, Henderson VW, Lash TL, Sørensen HT. Statin Initiation and Risk of Amyotrophic Lateral Sclerosis: A Danish Population-based Cohort Study. Epidemiology. 2021 09 01; 32(5):756-762.
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Jones LK, Tilberry S, Gregor C, Yaeger LH, Hu Y, Sturm AC, Seaton TL, Waltz TJ, Rahm AK, Goldberg A, Brownson RC, Gidding SS, Williams MS, Gionfriddo MR. Implementation strategies to improve statin utilization in individuals with hypercholesterolemia: a systematic review and meta-analysis. Implement Sci. 2021 04 13; 16(1):40.
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Katsanos AH, Lioutas VA, Charidimou A, Catanese L, Ng KKH, Perera K, de Sa Boasquevisque D, Falcone GJ, Sheth KN, Romero JR, Tsivgoulis G, Smith EE, Sharma M, Selim MH, Shoamanesh A. Statin treatment and cerebral microbleeds: A systematic review and meta-analysis. J Neurol Sci. 2021 01 15; 420:117224.
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Saeed O, Castagna F, Agalliu I, Xue X, Patel SR, Rochlani Y, Kataria R, Vukelic S, Sims DB, Alvarez C, Rivas-Lasarte M, Garcia MJ, Jorde UP. Statin Use and In-Hospital Mortality in Patients With Diabetes Mellitus and COVID-19. J Am Heart Assoc. 2020 12 15; 9(24):e018475.
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Sidebottom AC, Vacquier MC, Jensen JC, Bradley SM, Knickelbine T, Strauss C, Miedema MD. Trends in prevalence of guideline-based use of lipid-lowering therapy in a large health system. Clin Cardiol. 2020 Jun; 43(6):560-567.
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Dare RK, Van Driest SL, Talbot TR. Reply to Wasko et al. Clin Infect Dis. 2019 07 18; 69(3):559-560.
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Pathak R, Kumar VP, Hauer-Jensen M, Ghosh SP. Enhanced Survival in Mice Exposed to Ionizing Radiation by Combination of Gamma-Tocotrienol and Simvastatin. Mil Med. 2019 03 01; 184(Suppl 1):644-651.
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Dare RK, Tewell C, Harris B, Wright PW, Van Driest SL, Farber-Eger E, Nelson GE, Talbot TR. Effect of Statin Coadministration on the Risk of Daptomycin-Associated Myopathy. Clin Infect Dis. 2018 10 15; 67(9):1356-1363.
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Shanbhag A, Ananthula A, Reddy Palagiri RD, Parikh R, Purushothaman R, Vallurupalli S. Variation in High-Intensity Statin Use After Hospitalization for Acute Vascular Emergencies. Am J Med Sci. 2018 11; 356(5):501-502.
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Gurgle HE, Schauerhamer MB, Rodriguez SA, McAdam-Marx C. Impact of statin guidelines on statin utilization and costs in an employer-based primary care clinic. Am J Manag Care. 2017 Dec 01; 23(12):e387-e393.
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Rochlani Y, Kattoor AJ, Pothineni NV, Palagiri RDR, Romeo F, Mehta JL. Balancing Primary Prevention and Statin-Induced Diabetes Mellitus Prevention. Am J Cardiol. 2017 Oct 01; 120(7):1122-1128.
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Wolfe AR, Trenton NJ, Debeb BG, Larson R, Ruffell B, Chu K, Hittelman W, Diehl M, Reuben JM, Ueno NT, Woodward WA. Mesenchymal stem cells and macrophages interact through IL-6 to promote inflammatory breast cancer in pre-clinical models. Oncotarget. 2016 Dec 13; 7(50):82482-82492.
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Pathak R, Ghosh SP, Zhou D, Hauer-Jensen M. The Vitamin E Analog Gamma-Tocotrienol (GT3) and Statins Synergistically Up-Regulate Endothelial Thrombomodulin (TM). Int J Mol Sci. 2016 Nov 18; 17(11).
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Virani SS, Akeroyd JM, Ramsey DJ, Chan WJ, Frazier L, Nasir K, S Rajan S, Ballantyne CM, Petersen LA. Comparative effectiveness of outpatient cardiovascular disease and diabetes care delivery between advanced practice providers and physician providers in primary care: Implications for care under the Affordable Care Act. Am Heart J. 2016 Nov; 181:74-82.
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Adedinsewo D, Taka N, Agasthi P, Sachdeva R, Rust G, Onwuanyi A. Prevalence and Factors Associated With Statin Use Among a Nationally Representative Sample of US Adults: National Health and Nutrition Examination Survey, 2011-2012. Clin Cardiol. 2016 Sep; 39(9):491-6.
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Allott EH, Farnan L, Steck SE, Arab L, Su LJ, Mishel M, Fontham ET, Mohler JL, Bensen JT. Statin Use and Prostate Cancer Aggressiveness: Results from the Population-Based North Carolina-Louisiana Prostate Cancer Project. Cancer Epidemiol Biomarkers Prev. 2016 04; 25(4):670-7.
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Sexton T, Wallace EL, Smyth SS. Anti-Thrombotic Effects of Statins in Acute Coronary Syndromes: At the Intersection of Thrombosis, Inflammation, and Platelet-Leukocyte Interactions. Curr Cardiol Rev. 2016; 12(4):324-329.
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Greenway SC, Butts R, Naftel DC, Pruitt E, Kirklin JK, Larsen I, Urschel S, Knecht K, Law Y. Statin therapy is not associated with improved outcomes after heart transplantation in children and adolescents. J Heart Lung Transplant. 2016 Apr; 35(4):457-65.
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Wolfe AR, Debeb BG, Lacerda L, Larson R, Bambhroliya A, Huang X, Bertucci F, Finetti P, Birnbaum D, Van Laere S, Diagaradjan P, Ruffell B, Trenton NJ, Chu K, Hittelman W, Diehl M, Levental I, Ueno NT, Woodward WA. Simvastatin prevents triple-negative breast cancer metastasis in pre-clinical models through regulation of FOXO3a. Breast Cancer Res Treat. 2015 Dec; 154(3):495-508.
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Paixao AR, Enriquez JR, Wang TY, Li S, Berry JD, Khera A, Das SR, de Lemos JA, Kontos MC. Risk factor burden and control at the time of admission in patients with acute myocardial infarction: Results from the NCDR. Am Heart J. 2015 Jul; 170(1):173-9, 179.e1.
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Vengoechea J, McKelvey KD. Cholesterol and family history: when genetics matters. J Ark Med Soc. 2015 Feb; 111(9):184-6.
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Sexton TR, Wallace EL, Macaulay TE, Charnigo RJ, Evangelista V, Campbell CL, Bailey AL, Smyth SS. The effect of rosuvastatin on thromboinflammation in the setting of acute coronary syndrome. J Thromb Thrombolysis. 2015 Feb; 39(2):186-95.
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Sexton TR, Wallace EL, Macaulay TE, Charnigo RJ, Evangelista V, Campbell CL, Bailey AL, Smyth SS. The effect of rosuvastatin on platelet-leukocyte interactions in the setting of acute coronary syndrome. J Am Coll Cardiol. 2015 Jan 27; 65(3):306-7.
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Paixao AR, Ayers CR, Berry JD, de Lemos JA, Khera A. Atherosclerotic cardiovascular disease prevention: a comparison between the third adult treatment panel and the new 2013 Treatment of Blood Cholesterol Guidelines. Circ Cardiovasc Qual Outcomes. 2014 Sep; 7(5):778-9.
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Deng L, Ding Y, Peng Y, Wu Y, Fan J, Li W, Yang R, Yang M, Fu Q. ?-Tocotrienol protects against ovariectomy-induced bone loss via mevalonate pathway as HMG-CoA reductase inhibitor. Bone. 2014 Oct; 67:200-7.
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Paixao AR, de Lemos JA, Khera A. Application of the new cholesterol guidelines. N Engl J Med. 2014 07 03; 371(1):78.
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Dobesh PP, Olsen KM. Statins role in the prevention and treatment of sepsis. Pharmacol Res. 2014 Oct; 88:31-40.
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Wahawisan J, Tovar JM, Granberry MC. Statin therapy: when to think twice. J Fam Pract. 2013 Dec; 62(12):726-32.
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Chang J, Ahn JE, Landsman N, Rhee K, Chun L, Patel KK. Efficacy of contemporary medical management for asymptomatic carotid artery stenosis. Am Surg. 2013 Oct; 79(10):987-91.
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Robinson M, Gunning K, Pippitt K, McAdam-Marx C, Jennings BT. Team-based approach to addressing simvastatin safety concerns. J Am Pharm Assoc (2003). 2013 Sep-Oct; 53(5):539-44.
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Onono F, Subramanian T, Sunkara M, Subramanian KL, Spielmann HP, Morris AJ. Efficient use of exogenous isoprenols for protein isoprenylation by MDA-MB-231 cells is regulated independently of the mevalonate pathway. J Biol Chem. 2013 Sep 20; 288(38):27444-27455.
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