 Microglia
"Microglia" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The third type of glial cell, along with astrocytes and oligodendrocytes (which together form the macroglia). Microglia vary in appearance depending on developmental stage, functional state, and anatomical location; subtype terms include ramified, perivascular, ameboid, resting, and activated. Microglia clearly are capable of phagocytosis and play an important role in a wide spectrum of neuropathologies. They have also been suggested to act in several other roles including in secretion (e.g., of cytokines and neural growth factors), in immunological processing (e.g., antigen presentation), and in central nervous system development and remodeling.
| Descriptor ID |
D017628
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| MeSH Number(s) |
A08.637.400 A11.650.400
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Microglia".
Below are MeSH descriptors whose meaning is more specific than "Microglia".
This graph shows the total number of publications written about "Microglia" by people in UAMS Profiles by year, and whether "Microglia" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2025 | 3 | 3 | 6 | | 2024 | 2 | 1 | 3 | | 2023 | 1 | 0 | 1 | | 2022 | 1 | 0 | 1 | | 2021 | 2 | 3 | 5 | | 2020 | 3 | 1 | 4 | | 2019 | 1 | 1 | 2 | | 2018 | 1 | 1 | 2 | | 2017 | 1 | 1 | 2 | | 2016 | 0 | 1 | 1 | | 2015 | 2 | 1 | 3 | | 2014 | 0 | 2 | 2 | | 2013 | 2 | 1 | 3 | | 2012 | 1 | 4 | 5 | | 2011 | 1 | 0 | 1 | | 2010 | 1 | 0 | 1 | | 2009 | 0 | 1 | 1 | | 2008 | 0 | 2 | 2 | | 2007 | 4 | 0 | 4 | | 2006 | 3 | 1 | 4 | | 2005 | 8 | 1 | 9 | | 2004 | 2 | 4 | 6 | | 2003 | 2 | 2 | 4 | | 2002 | 1 | 2 | 3 | | 2001 | 2 | 0 | 2 | | 2000 | 3 | 0 | 3 | | 1998 | 1 | 0 | 1 | | 1996 | 2 | 0 | 2 | | 1995 | 1 | 0 | 1 |
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Below are the most recent publications written about "Microglia" by people in Profiles over the past ten years.
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Fu Q, Qiu R, Tang Q, Li X, Li Y, Qin Y, Li Q, Yao J, Jiang Z, Xu H, Cheng Y. Exosomes from high-altitude cerebral edema patients induce cognitive dysfunction by altering oxidative stress responses in mice. Transl Psychiatry. 2025 Jul 22; 15(1):253.
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Martinez-Perez DA, McGlothan JL, Rodichkin AN, Abilmouna K, Bursac Z, Lopera F, Villegas-Lanau CA, Guilarte TR. Amyloid-? plaque-associated microglia drive TSPO upregulation in Alzheimer's disease. Acta Neuropathol. 2025 Jul 17; 150(1):6.
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Morris CA, Sadek MA, Modi P, Abdelnaem S, Rusch NJ, Shosha E, Fouda AY. The role of efferocytosis in ischemic stroke and insights from retinopathy. Trends Neurosci. 2025 Aug; 48(8):624-639.
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Verma A, Azhar G, Patyal P, Zhang X, Wei JY. Porphyromonas gingivalis-Lipopolysaccharide Induced Caspase-4 Dependent Noncanonical Inflammasome Activation Drives Alzheimer's Disease Pathologies. Cells. 2025 05 30; 14(11).
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Wang J, Zhang H, Augenreich M, Martinez-Lemus A L, Liu Z, Kang X, Lu B, Chang HM, Yeh ETH, Cata J, Rangaraju S, Wulff H, Li DP. Microglia-Mediated Synaptic Dysfunction Contributes to Chemotherapy-Related Cognitive Impairment. J Neurochem. 2025 Mar; 169(3):e70024.
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Li M, Feng M, Liu T, Duan S, Man X, Yuan X, Wang L, Sun Y, Wei X, Fu Q, Sun B, Lin W. Increased ocular plasma cells induce damaging a-synuclein+ microglia in autoimmune uveitis. Mucosal Immunol. 2025 Jun; 18(3):668-684.
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Schartz ND, Liang HY, Carvalho K, Chu SH, Mendoza-Arvilla A, Petrisko TJ, Gomez-Arboledas A, Mortazavi A, Tenner AJ. C5aR1 antagonism suppresses inflammatory glial responses and alters cellular signaling in an Alzheimer's disease mouse model. Nat Commun. 2024 Aug 15; 15(1):7028.
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Vinnakota JM, Biavasco F, Schwabenland M, Chhatbar C, Adams RC, Erny D, Duquesne S, El Khawanky N, Schmidt D, Fetsch V, Z?hringer A, Sali? H, Athanassopoulos D, Braun LM, Javorniczky NR, Ho JNHG, Kierdorf K, Marks R, W?sch R, Simonetta F, Andrieux G, Pfeifer D, Monaco G, Capitini C, Fry TJ, Blank T, Blazar BR, Wagner E, Theobald M, Sommer C, Stelljes M, Reicherts C, Jeibmann A, Schittenhelm J, Monoranu CM, Rosenwald A, Kort?m M, Rasche L, Einsele H, Meyer PT, Brumberg J, V?lkl S, Mackensen A, Coras R, von Bergwelt-Baildon M, Albert NL, Bartos LM, Brendel M, Holzgreve A, Mack M, Boerries M, Mackall CL, Duyster J, Henneke P, Priller J, K?hler N, Str?bing F, Bengsch B, Ruella M, Subklewe M, von Baumgarten L, Gill S, Prinz M, Zeiser R. Targeting TGF?-activated kinase-1 activation in microglia reduces CAR T immune effector cell-associated neurotoxicity syndrome. Nat Cancer. 2024 Aug; 5(8):1227-1249.
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Verma A, Azhar G, Patyal P, Zhang W, Zhang X, Wei JY. Proteomic analysis of P. gingivalis-Lipopolysaccharide induced neuroinflammation in SH-SY5Y and HMC3 cells. Geroscience. 2024 Oct; 46(5):4315-4332.
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Cealie MY, Douglas JC, Swan HK, Vonkaenel ED, McCall MN, Drew PD, Majewska AK. Developmental Ethanol Exposure Impacts Purkinje Cells but Not Microglia in the Young Adult Cerebellum. Cells. 2024 02 23; 13(5).
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Gajewski MP, Barger SW. Design, synthesis, and characterization of novel system xC- transport inhibitors: inhibition of microglial glutamate release and neurotoxicity. J Neuroinflammation. 2023 Dec 06; 20(1):292.
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Paolicelli RC, Sierra A, Stevens B, Tremblay ME, Aguzzi A, Ajami B, Amit I, Audinat E, Bechmann I, Bennett M, Bennett F, Bessis A, Biber K, Bilbo S, Blurton-Jones M, Boddeke E, Brites D, Br?ne B, Brown GC, Butovsky O, Carson MJ, Castellano B, Colonna M, Cowley SA, Cunningham C, Davalos D, De Jager PL, de Strooper B, Denes A, Eggen BJL, Eyo U, Galea E, Garel S, Ginhoux F, Glass CK, Gokce O, Gomez-Nicola D, Gonz?lez B, Gordon S, Graeber MB, Greenhalgh AD, Gressens P, Greter M, Gutmann DH, Haass C, Heneka MT, Heppner FL, Hong S, Hume DA, Jung S, Kettenmann H, Kipnis J, Koyama R, Lemke G, Lynch M, Majewska A, Malcangio M, Malm T, Mancuso R, Masuda T, Matteoli M, McColl BW, Miron VE, Molofsky AV, Monje M, Mracsko E, Nadjar A, Neher JJ, Neniskyte U, Neumann H, Noda M, Peng B, Peri F, Perry VH, Popovich PG, Pridans C, Priller J, Prinz M, Ragozzino D, Ransohoff RM, Salter MW, Schaefer A, Schafer DP, Schwartz M, Simons M, Smith CJ, Streit WJ, Tay TL, Tsai LH, Verkhratsky A, von Bernhardi R, Wake H, Wittamer V, Wolf SA, Wu LJ, Wyss-Coray T. Microglia states and nomenclature: A field at its crossroads. Neuron. 2022 11 02; 110(21):3458-3483.
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Gomez-Arboledas A, Carvalho K, Balderrama-Gutierrez G, Chu SH, Liang HY, Schartz ND, Selvan P, Petrisko TJ, Pan MA, Mortazavi A, Tenner AJ. C5aR1 antagonism alters microglial polarization and mitigates disease progression in a mouse model of Alzheimer's disease. Acta Neuropathol Commun. 2022 08 17; 10(1):116.
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Carvalho K, Schartz ND, Balderrama-Gutierrez G, Liang HY, Chu SH, Selvan P, Gomez-Arboledas A, Petrisko TJ, Fonseca MI, Mortazavi A, Tenner AJ. Modulation of C5a-C5aR1 signaling alters the dynamics of AD progression. J Neuroinflammation. 2022 Jul 11; 19(1):178.
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Niedzwiedz-Massey VM, Douglas JC, Rafferty T, Wight PA, Kane CJM, Drew PD. Ethanol modulation of hippocampal neuroinflammation, myelination, and neurodevelopment in a postnatal mouse model of fetal alcohol spectrum disorders. Neurotoxicol Teratol. 2021 Sep-Oct; 87:107015.
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Zhang Y, Yan Y, Meng J, Girotra M, Ramakrishnan S, Roy S. Immune modulation mediated by extracellular vesicles of intestinal organoids is disrupted by opioids. Mucosal Immunol. 2021 07; 14(4):887-898.
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Candadai AA, Liu F, Fouda AY, Alfarhan M, Palani CD, Xu Z, Caldwell RB, Narayanan SP. Deletion of arginase 2 attenuates neuroinflammation in an experimental model of optic neuritis. PLoS One. 2021; 16(3):e0247901.
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Lowery RL, Cealie MY, Lamantia CE, Mendes MS, Drew PD, Majewska AK. Microglia and astrocytes show limited, acute alterations in morphology and protein expression following a single developmental alcohol exposure. J Neurosci Res. 2021 08; 99(8):2008-2025.
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Kane CJM, Douglas JC, Rafferty T, Johnson JW, Niedzwiedz-Massey VM, Phelan KD, Majewska AK, Drew PD. Ethanol modulation of cerebellar neuroinflammation in a postnatal mouse model of fetal alcohol spectrum disorders. J Neurosci Res. 2021 08; 99(8):1986-2007.
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Park GH, Noh H, Shao Z, Ni P, Qin Y, Liu D, Beaudreault CP, Park JS, Abani CP, Park JM, Le DT, Gonzalez SZ, Guan Y, Cohen BM, McPhie DL, Coyle JT, Lanz TA, Xi HS, Yin C, Huang W, Kim HY, Chung S. Activated microglia cause metabolic disruptions in developmental cortical interneurons that persist in interneurons from individuals with schizophrenia. Nat Neurosci. 2020 11; 23(11):1352-1364.
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Kane CJM, Drew PD. Neuroinflammatory contribution of microglia and astrocytes in fetal alcohol spectrum disorders. J Neurosci Res. 2021 08; 99(8):1973-1985.
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Fouda AY, Xu Z, Narayanan SP, Caldwell RW, Caldwell RB. Utility of LysM-cre and Cdh5-cre Driver Mice in Retinal and Brain Research: An Imaging Study Using tdTomato Reporter Mouse. Invest Ophthalmol Vis Sci. 2020 03 09; 61(3):51.
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Aghaie CI, Hausknecht KA, Wang R, Dezfuli PH, Haj-Dahmane S, Kane CJM, Sigurdson WJ, Shen RY. Prenatal Ethanol Exposure and Postnatal Environmental Intervention Alter Dopaminergic Neuron and Microglia Morphology in the Ventral Tegmental Area During Adulthood. Alcohol Clin Exp Res. 2020 02; 44(2):435-444.
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Palani CD, Fouda AY, Liu F, Xu Z, Mohamed E, Giri S, Smith SB, Caldwell RB, Narayanan SP. Deletion of Arginase 2 Ameliorates Retinal Neurodegeneration in a Mouse Model of Multiple Sclerosis. Mol Neurobiol. 2019 Dec; 56(12):8589-8602.
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Moriarty O, Tu Y, Sengar AS, Salter MW, Beggs S, Walker SM. Priming of Adult Incision Response by Early-Life Injury: Neonatal Microglial Inhibition Has Persistent But Sexually Dimorphic Effects in Adult Rats. J Neurosci. 2019 04 17; 39(16):3081-3093.
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Walters JL, Zhang X, Talpos JC, Fogle CM, Li M, Chelonis JJ, Paule MG. Sevoflurane exposure has minimal effect on cognitive function and does not alter microglial activation in adult monkeys. Neurotoxicology. 2019 03; 71:159-167.
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Kulas JA, Franklin WF, Smith NA, Manocha GD, Puig KL, Nagamoto-Combs K, Hendrix RD, Taglialatela G, Barger SW, Combs CK. Ablation of amyloid precursor protein increases insulin-degrading enzyme levels and activity in brain and peripheral tissues. Am J Physiol Endocrinol Metab. 2019 01 01; 316(1):E106-E120.
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Jevtic S, Sengar AS, Salter MW, McLaurin J. The role of the immune system in Alzheimer disease: Etiology and treatment. Ageing Res Rev. 2017 Nov; 40:84-94.
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Salter MW, Stevens B. Microglia emerge as central players in brain disease. Nat Med. 2017 Sep 08; 23(9):1018-1027.
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Kane CJ, Drew PD. Inflammatory responses to alcohol in the CNS: nuclear receptors as potential therapeutics for alcohol-induced neuropathologies. J Leukoc Biol. 2016 11; 100(5):951-959.
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Schartz ND, Herr SA, Madsen L, Butts SJ, Torres C, Mendez LB, Brewster AL. Spatiotemporal profile of Map2 and microglial changes in the hippocampal CA1 region following pilocarpine-induced status epilepticus. Sci Rep. 2016 05 04; 6:24988.
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Jalin AM, Rajasekaran M, Prather PL, Kwon JS, Gajulapati V, Choi Y, Kim C, Pahk K, Ju C, Kim WK. Non-Selective Cannabinoid Receptor Antagonists, Hinokiresinols Reduce Infiltration of Microglia/Macrophages into Ischemic Brain Lesions in Rat via Modulating 2-Arachidonolyglycerol-Induced Migration and Mitochondrial Activity. PLoS One. 2015; 10(10):e0141600.
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