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Tuhin Virmani

TitleAssociate Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentNeurology, College of Medicine
DivisionNeurology Faculty
Address Hospital (new hospital)
4200 Shuffield.
Mail Slot # 500
Little Rock AR 72205
Phone501-686-7235
ORCID ORCID Icon0000-0002-1826-2020 Additional info
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    Collapse Overview 
    Collapse overview
    Dr. Virmani completed his medical training at UT Southwestern Medical School in Dallas where he was in the Medical Scientist Training Program (MSTP) receiving a combined M.D/Ph.D degree. His research in basic neuroscience explored the physiologic mechanisms by which neurons in the brain communicate with one other using chemical neurotransmitters at the synapse. He then went on to pursue a residency in Neurology at Washington University in St. Louis where he developed an interest in Movement Disorders. This lead to a two year combined clinical-research fellowship in Movement Disorders under the guidance of Dr. Stanley Fahn and other members of the Center for Parkinson Disease and other Movement Disorders at Columbia University Medical Center in New York. While at Columbia University, Dr. Virmani became interested in the principles underlying the phenomenon of freezing of gait in Parkinson disease and he undertook a clinicopathologic study under the mentorship of Dr. Fahn and Dr. Jean-Paul Vonsattel (Department of Pathology). He also worked with Dr. Fahn to start a clinical trial using a novel motor-neuronotrophic factor for potential neuroprotection in Parkinson disease. This trial is currently underway. In addition to his clinical duties as the Director of the Movement Disorders program at UAMS, Dr. Virmani plans to continue to develop his research interests with the establishment of a gait lab and eventual participation in national clinical research trials.


    Collapse Biography 
    Collapse Leadership and Administrative Roles
    Director Movement Disorders Neurology Program

    Director Huntington's Disease Society's Center of Excellence at UAMS

    Collapse education and training
    Brandeis University, Waltham, MABS05/1999Physics/Biology
    UT Southwestern Medical School, Dallas, TXMD/PhD06/2007Neuroscience
    Washington University Medical/Barnes Jewish Hospital School, St. Louis, MOInternship06/2008Internal Medicine
    Washington University Medical/Barnes Jewish Hospital School, St. Louis, MOResidency06/2011Neurology
    Columbia University Medical Center, New York, NYFellowship06/2013Movement Disorders

    Collapse Research 
    Collapse research activities and funding
    PTC2020-07     (Virmani, Tuhin)Aug 1, 2020 - Jul 31, 2021
    NIH/NCATS UL1TR003107
    Utilization of a Neuroinformatics Research Platform (ARIES) to Develop Quantitative Tools for Clinical Assessment and Treatment of Parkinson’s Disease Patients in Rural Arkansas
    Role Description: The goal of this study is to develop telehealth digital data collection methods for evaluation of multi-modal function in people with Parkinson’s Disease (PwPD) and develop biomedical informatics tools for collation, storage and future data exploration.
    Role: Principal Investigator

    PF-JFA-1935     (VIRMANI, TUHIN)Jun 1, 2019 - Nov 30, 2022
    Parkinson's Foundation
    Freezing of gait in Parkinson's disease: From development of predictive algorithms to testing novel therapeutics
    Role: Principal Investigator

    U24CA215109     (PRIOR, FRED WILLIAM)Sep 22, 2017 - Jul 31, 2022
    NIH
    TCIA Sustainment and Scalability - Platforms for Quantitative Imaging Informatics in Precision Medicine
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Landes RD, Glover A, Pillai L, Doerhoff S, Virmani T. Levodopa ONOFF-state freezing of gait: Defining the gait and non-motor phenotype. PLoS One. 2022; 17(6):e0269227. PMID: 35653359.
      View in: PubMed
    2. Pillai L, Glover A, Virmani T. A study of turn bias in people with idiopathic Parkinson's disease. Exp Brain Res. 2022 Jun; 240(6):1673-1685. PMID: 35551430.
      View in: PubMed
    3. Syeda HB, Glover A, Pillai L, Kemp AS, Spencer H, Lotia M, Larson-Prior LJ, Virmani T. Amplitude setting and dopamine response of finger tapping and gait are related in Parkinson's disease. Sci Rep. 2022 03 09; 12(1):4180. PMID: 35264705.
      View in: PubMed
    4. Scott H, Griffin C, Coggins W, Elberson B, Abdeldayem M, Virmani T, Larson-Prior LJ, Petersen E. Virtual Reality in the Neurosciences: Current Practice and Future Directions. Front Surg. 2021; 8:807195. PMID: 35252318.
      View in: PubMed
    5. Bona J, Kemp AS, Cox C, Nolan TS, Pillai L, Das A, Galvin JE, Larson-Prior L, Virmani T, Prior F. Semantic Integration of Multi-Modal Data and Derived Neuroimaging Results Using the Platform for Imaging in Precision Medicine (PRISM) in the Arkansas Imaging Enterprise System (ARIES). Front Artif Intell. 2021; 4:649970. PMID: 35224477.
      View in: PubMed
    6. Pillai L, Shah K, Glover A, Virmani T. Increased foot strike variability during turning in Parkinson's disease patients with freezing of gait. Gait Posture. 2022 02; 92:321-327. PMID: 34915403.
      View in: PubMed
    7. Glover A, Pillai L, Dhall R, Virmani T. Olfactory Deficits in the Freezing of Gait Phenotype of Parkinson's Disease. Front Neurol. 2021; 12:656379. PMID: 34456839.
      View in: PubMed
    8. Virmani T, Glover A, Pillai L, Lotia M, Dhall R. Utility of objective gait measures in levodopa-unresponsive freezing in Parkinson's. Clin Case Rep. 2021 Mar; 9(3):1072-1077. PMID: 33768785.
      View in: PubMed
    9. Glover A, Pillai L, Doerhoff S, Virmani T. Differential Gait Decline in Parkinson's Disease Enhances Discrimination of Gait Freezers from Non-Freezers. J Parkinsons Dis. 2020; 10(4):1657-1673. PMID: 32925092.
      View in: PubMed
    10. Virmani T, Urbano FJ, Bisagno V, Garcia-Rill E. The pedunculopontine nucleus: From posture and locomotion to neuroepigenetics. AIMS Neurosci. 2019; 6(4):219-230. PMID: 32341978.
      View in: PubMed
    11. Sharma R, Pillai L, Glover A, Virmani T. Objective impairment of tandem gait in Parkinson's disease patients increases with disease severity. Parkinsonism Relat Disord. 2019 11; 68:33-39. PMID: 31621615.
      View in: PubMed
    12. Harada Y, Virmani T, Gokden M, Stefans V. Toxic Myopathy due to Antidopaminergic Medication Without Neuroleptic Malignant Syndrome. J Clin Neuromuscul Dis. 2018 Dec; 20(2):94-98. PMID: 30439755.
      View in: PubMed
    13. Virmani T, Pillai L, Glover A, Doerhoff SM, Williams DK, Garcia-Rill E, Larson-Prior L. Impaired step-length setting prior to turning in Parkinson's disease patients with freezing of gait. Mov Disord. 2018 11; 33(11):1823-1825. PMID: 30306629.
      View in: PubMed
    14. Langston RG, Virmani T. Use of a Modified STROOP Test to Assess Color Discrimination Deficit in Parkinson's Disease. Front Neurol. 2018; 9:765. PMID: 30258399.
      View in: PubMed
    15. Virmani T, Gupta H, Shah J, Larson-Prior L. Objective measures of gait and balance in healthy non-falling adults as a function of age. Gait Posture. 2018 09; 65:100-105. PMID: 30558914.
      View in: PubMed
    16. Shah J, Pillai L, Williams DK, Doerhoff SM, Larson-Prior L, Garcia-Rill E, Virmani T. Increased foot strike variability in Parkinson's disease patients with freezing of gait. Parkinsonism Relat Disord. 2018 08; 53:58-63. PMID: 29773512.
      View in: PubMed
    17. Innabi A, Limaye K, Cobb S, Samant R, Virmani T. Caution! Self-supplementation may be injurious to your health. Acta Neurol Belg. 2017 09; 117(3):781-782. PMID: 28013488.
      View in: PubMed
    18. Virmani T, Tazan S, Mazzoni P, Ford B, Greene PE. Motor fluctuations due to interaction between dietary protein and levodopa in Parkinson's disease. J Clin Mov Disord. 2016; 3:8. PMID: 27231577.
      View in: PubMed
    19. Robakis D, Cortes E, Clark LN, Vonsattel JP, Virmani T, Alcalay RN, Crary JF, Levy OA. The effect of MAPT haplotype on neocortical Lewy body pathology in Parkinson disease. J Neural Transm (Vienna). 2016 06; 123(6):583-8. PMID: 27098667.
      View in: PubMed
    20. Garcia-Rill E, Virmani T, Hyde JR, D'Onofrio S, Mahaffey S. Arousal and the control of perception and movement. Curr Trends Neurol. 2016; 10:53-64. PMID: 28690375.
      View in: PubMed
    21. Gupta HV, Vengoechea J, Sahaya K, Virmani T. A splice site mutation in ATP6AP2 causes X-linked intellectual disability, epilepsy, and parkinsonism. Parkinsonism Relat Disord. 2015 Dec; 21(12):1473-5. PMID: 26467484.
      View in: PubMed
    22. Gupta HV, Samant R, Gokden M, Lee RW, Sahaya K, Virmani T. Clinical Reasoning: A 73-year-old man with diplopia and ataxia. Neurology. 2015 Sep 29; 85(13):e96-100. PMID: 26416806.
      View in: PubMed
    23. Virmani T, Moskowitz CB, Vonsattel JP, Fahn S. Clinicopathological characteristics of freezing of gait in autopsy-confirmed Parkinson's disease. Mov Disord. 2015 Dec; 30(14):1874-84. PMID: 26234730.
      View in: PubMed
    24. Virmani T, Rotstein M, Spiegel R, Akman HO, DiMauro S, Greene PE. Levodopa Responsive Parkinsonism in Two Patients With Phosphoglycerate Kinase Deficiency. Mov Disord Clin Pract. 2014 Sep; 1(3):240-242. PMID: 30713856.
      View in: PubMed
    25. Virmani T, Thenganatt MA, Goldman JS, Kubisch C, Greene PE, Alcalay RN. Oculogyric crises induced by levodopa in PLA2G6 parkinsonism-dystonia. Parkinsonism Relat Disord. 2014 Feb; 20(2):245-7. PMID: 24182522.
      View in: PubMed
    26. Virmani T, Greene PE, Pearson TS. Delayed onset of progressive chorea after acute basal ganglia injury. Mov Disord. 2013 May; 28(5):585-7. PMID: 23677897.
      View in: PubMed
    27. Virmani T, Louis ED, Waters C, Pullman SL. Familial orthostatic tremor: an additional report in siblings. Neurology. 2012 Jul 17; 79(3):288-9. PMID: 22764256.
      View in: PubMed
    28. Virmani T, Agarwal A, Klawiter EC. Clinical reasoning: A young adult presents with focal weakness and hemorrhagic brain lesions. Neurology. 2011 May 31; 76(22):e106-9. PMID: 21624981.
      View in: PubMed
    29. Ertunc M, Sara Y, Chung C, Atasoy D, Virmani T, Kavalali ET. Fast synaptic vesicle reuse slows the rate of synaptic depression in the CA1 region of hippocampus. J Neurosci. 2007 Jan 10; 27(2):341-54. PMID: 17215395.
      View in: PubMed
    30. Bloustine J, Virmani T, Thurston GM, Fraden S. Light scattering and phase behavior of lysozyme-poly(ethylene glycol) mixtures. Phys Rev Lett. 2006 Mar 03; 96(8):087803. PMID: 16606227.
      View in: PubMed
    31. Virmani T, Atasoy D, Kavalali ET. Synaptic vesicle recycling adapts to chronic changes in activity. J Neurosci. 2006 Feb 22; 26(8):2197-206. PMID: 16495446.
      View in: PubMed
    32. Virmani T, Ertunc M, Sara Y, Mozhayeva M, Kavalali ET. Phorbol esters target the activity-dependent recycling pool and spare spontaneous vesicle recycling. J Neurosci. 2005 Nov 23; 25(47):10922-9. PMID: 16306405.
      View in: PubMed
    33. Virmani T, Gupta P, Liu X, Kavalali ET, Hofmann SL. Progressively reduced synaptic vesicle pool size in cultured neurons derived from neuronal ceroid lipofuscinosis-1 knockout mice. Neurobiol Dis. 2005 Nov; 20(2):314-23. PMID: 16242638.
      View in: PubMed
    34. Luikart BW, Nef S, Virmani T, Lush ME, Liu Y, Kavalali ET, Parada LF. TrkB has a cell-autonomous role in the establishment of hippocampal Schaffer collateral synapses. J Neurosci. 2005 Apr 13; 25(15):3774-86. PMID: 15829629.
      View in: PubMed
    35. Sara Y, Virmani T, Deák F, Liu X, Kavalali ET. An isolated pool of vesicles recycles at rest and drives spontaneous neurotransmission. Neuron. 2005 Feb 17; 45(4):563-73. PMID: 15721242.
      View in: PubMed
    36. Virmani, T, Kavalali, ET. Synaptic Plasticity and Transsynaptic Signaling. Synaptic Vesicle Recycling As A Substrate For Neural Plasticity. 2005.
    37. Virmani T, Han W, Liu X, Südhof TC, Kavalali ET. Synaptotagmin 7 splice variants differentially regulate synaptic vesicle recycling. EMBO J. 2003 Oct 15; 22(20):5347-57. PMID: 14532108.
      View in: PubMed
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