 Glutathione
"Glutathione" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.
| Descriptor ID |
D005978
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| MeSH Number(s) |
D12.644.456.448
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| Concept/Terms |
Glutathione- Glutathione
- gamma-L-Glutamyl-L-Cysteinylglycine
- gamma L Glutamyl L Cysteinylglycine
- gamma-L-Glu-L-Cys-Gly
- gamma L Glu L Cys Gly
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Below are MeSH descriptors whose meaning is more general than "Glutathione".
Below are MeSH descriptors whose meaning is more specific than "Glutathione".
This graph shows the total number of publications written about "Glutathione" by people in UAMS Profiles by year, and whether "Glutathione" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2025 | 0 | 2 | 2 | | 2024 | 1 | 0 | 1 | | 2023 | 0 | 2 | 2 | | 2022 | 1 | 1 | 2 | | 2021 | 1 | 3 | 4 | | 2020 | 0 | 2 | 2 | | 2019 | 0 | 3 | 3 | | 2018 | 1 | 1 | 2 | | 2017 | 1 | 4 | 5 | | 2016 | 2 | 7 | 9 | | 2015 | 3 | 7 | 10 | | 2014 | 2 | 5 | 7 | | 2013 | 2 | 9 | 11 | | 2012 | 2 | 7 | 9 | | 2011 | 1 | 5 | 6 | | 2010 | 1 | 5 | 6 | | 2009 | 4 | 5 | 9 | | 2008 | 6 | 4 | 10 | | 2007 | 2 | 7 | 9 | | 2006 | 3 | 3 | 6 | | 2005 | 2 | 5 | 7 | | 2004 | 3 | 5 | 8 | | 2003 | 4 | 8 | 12 | | 2002 | 2 | 3 | 5 | | 2001 | 2 | 2 | 4 | | 2000 | 3 | 2 | 5 | | 1999 | 2 | 4 | 6 | | 1998 | 2 | 6 | 8 | | 1997 | 3 | 0 | 3 | | 1996 | 0 | 3 | 3 | | 1995 | 1 | 2 | 3 | | 1994 | 2 | 2 | 4 | | 1993 | 0 | 1 | 1 | | 1992 | 3 | 3 | 6 | | 1991 | 3 | 1 | 4 |
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Below are the most recent publications written about "Glutathione" by people in Profiles over the past ten years.
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Ali NA, Kennon-McGill S, Parker LD, James LP, Fantegrossi WE, McGill MR. NAPQI is absent in the mouse brain after sub-hepatotoxic and hepatotoxic doses of acetaminophen. Toxicol Sci. 2025 Jun 01; 205(2):274-278.
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Khalaf RR, Abouzeinab NS, Khalil MI. Effects of Lebanese Folk Herbs on Adult Male Rats: Hepatic and Renal Toxicity, Histological, and Biochemical Studies. Nutrients. 2025 Feb 28; 17(5).
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Chouinard VA, Feizi W, Chen X, Ren B, Lewandowski KE, Anderson J, Prete S, Tusuzian E, Cuklanz K, Zhou S, Bolton P, Stein A, Cohen BM, Du F, ?ng?r D. Intranasal Insulin Increases Brain Glutathione and Enhances Antioxidant Capacity in Healthy Participants but Not in Those With Early Psychotic Disorders. Biol Psychiatry Cogn Neurosci Neuroimaging. 2025 Mar; 10(3):286-294.
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Snyder EL, Sekela ME, Welsby IJ, Toyoda Y, Alsammak M, Sodha NR, Beaver TM, Pelletier JPR, Gorham JD, McNeil JS, Sniecinski RM, Pearl RG, Nuttall GA, Sarode R, Reece TB, Kaplan A, Davenport RD, Ipe TS, Benharash P, Lopez-Plaza I, Gammon RR, Sadler P, Pitman JP, Liu K, Bentow S, Corash L, Mufti N, Varrone J, Benjamin RJ. Evaluation of the efficacy and safety of amustaline/glutathione pathogen-reduced RBCs in complex cardiac surgery: the Red Cell Pathogen Inactivation (ReCePI) study-protocol for a phase 3, randomized, controlled trial. Trials. 2023 Dec 11; 24(1):799.
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Yiew NKH, Vazquez JH, Martino MR, Kennon-McGill S, Price JR, Allard FD, Yee EU, Layman AJ, James LP, McCommis KS, Finck BN, McGill MR. Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult. Mol Metab. 2023 Nov; 77:101808.
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Olson KR, Clear KJ, Gao Y, Ma Z, Cieplik NM, Fiume AR, Gaziano DJ, Kasko SM, Luu J, Pfaff E, Travlos A, Velander C, Wilson KJ, Edwards ED, Straub KD, Wu G. Redox and Nucleophilic Reactions of Naphthoquinones with Small Thiols and Their Effects on Oxidization of H2S to Inorganic and Organic Hydropolysulfides and Thiosulfate. Int J Mol Sci. 2023 Apr 19; 24(8).
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Yapca OE, Yildiz GA, Mammadov R, Kurt N, Gundogdu B, Arslan YK, Suleyman H, Cetin N. The effects of metyrosine on ischemia-reperfusion-induced oxidative ovarian injury in rats: Biochemical and histopathological assessment. An Acad Bras Cienc. 2023; 95(2):e20201586.
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Carey ME, Rando J, Melnyk S, James SJ, Snyder N, Salafia C, Croen LA, Fallin MD, Hertz-Picciotto I, Volk H, Newschaffer C, Lyall K. Examining associations between prenatal biomarkers of oxidative stress and ASD-related outcomes using quantile regression. J Autism Dev Disord. 2023 Aug; 53(8):2975-2985.
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Ozer M, Ince S, Gundogdu B, Aktas M, Uzel K, Gursul C, Suleyman H, Suleyman Z. Effect of thiamine pyrophosphate on cyclophosphamide-induced oxidative ovarian damage and reproductive dysfunction in female rats. Adv Clin Exp Med. 2022 Feb; 31(2):129-137.
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Subramani J, Kundumani-Sridharan V, Das KC. Chaperone-Mediated Autophagy of eNOS in Myocardial Ischemia-Reperfusion Injury. Circ Res. 2021 10 29; 129(10):930-945.
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Schleiff MA, Payakachat S, Schleiff BM, Swamidass SJ, Boysen G, Miller GP. Impacts of diphenylamine NSAID halogenation on bioactivation risks. Toxicology. 2021 06 30; 458:152832.
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Elsawy H, Alzahrani AM, Alfwuaires M, Sedky A, El-Trass EE, Mahmoud O, Abdel-Moneim AM, Khalil M. Analysis of silymarin-modulating effects against acrylamide-induced cerebellar damage in male rats: Biochemical and pathological markers. J Chem Neuroanat. 2021 09; 115:101964.
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Bj?rklund G, Dosa MD, Maes M, Dadar M, Frye RE, Peana M, Chirumbolo S. The impact of glutathione metabolism in autism spectrum disorder. Pharmacol Res. 2021 04; 166:105437.
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Boysen G, Arora R, Degner A, Vevang KR, Chao C, Rodriguez F, Walmsley SJ, Erber L, Tretyakova NY, Peterson LA. Effects of GSTT1 Genotype on the Detoxification of 1,3-Butadiene Derived Diepoxide and Formation of Promutagenic DNA-DNA Cross-Links in Human Hapmap Cell Lines. Chem Res Toxicol. 2021 01 18; 34(1):119-131.
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Schleiff MA, Flynn NR, Payakachat S, Schleiff BM, Pinson AO, Province DW, Swamidass SJ, Boysen G, Miller GP. Significance of Multiple Bioactivation Pathways for Meclofenamate as Revealed through Modeling and Reaction Kinetics. Drug Metab Dispos. 2021 02; 49(2):133-141.
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Kennedy RC, Smith AK, Ropella GEP, McGill MR, Jaeschke H, Hunt CA. Propagation of Pericentral Necrosis During Acetaminophen-Induced Liver Injury: Evidence for Early Interhepatocyte Communication and Information Exchange. Toxicol Sci. 2019 05 01; 169(1):151-166.
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Boysen G, Jamshidi-Parsian A, Davis MA, Siegel ER, Simecka CM, Kore RA, Dings RPM, Griffin RJ. Glutaminase inhibitor CB-839 increases radiation sensitivity of lung tumor cells and human lung tumor xenografts in mice. Int J Radiat Biol. 2019 04; 95(4):436-442.
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Cichocki JA, Luo YS, Furuya S, Venkatratnam A, Konganti K, Chiu WA, Threadgill DW, Pogribny IP, Rusyn I. Modulation of Tetrachloroethylene-Associated Kidney Effects by Nonalcoholic Fatty Liver or Steatohepatitis in Male C57BL/6J Mice. Toxicol Sci. 2019 01 01; 167(1):126-137.
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Cadirci E, Ugan RA, Dincer B, Gundogdu B, Cinar I, Akpinar E, Halici Z. Urotensin receptors as a new target for CLP induced septic lung injury in mice. Naunyn Schmiedebergs Arch Pharmacol. 2019 02; 392(2):135-145.
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McGreal SR, Bhushan B, Walesky C, McGill MR, Lebofsky M, Kandel SE, Winefield RD, Jaeschke H, Zachara NE, Zhang Z, Tan EP, Slawson C, Apte U. Modulation of O-GlcNAc Levels in the Liver Impacts Acetaminophen-Induced Liver Injury by Affecting Protein Adduct Formation and Glutathione Synthesis. Toxicol Sci. 2018 04 01; 162(2):599-610.
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Cholia RP, Kumari S, Kumar S, Kaur M, Kaur M, Kumar R, Dhiman M, Mantha AK. An in vitro study ascertaining the role of H2O2 and glucose oxidase in modulation of antioxidant potential and cancer cell survival mechanisms in glioblastoma U-87 MG cells. Metab Brain Dis. 2017 10; 32(5):1705-1716.
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Lantz SM, Rosas-Hernandez H, Cuevas E, Robinson B, Rice KC, Fantegrossi WE, Imam SZ, Paule MG, Ali SF. Monoaminergic toxicity induced by cathinone phthalimide: An in vitro study. Neurosci Lett. 2017 Aug 10; 655:76-81.
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Boysen G. The Glutathione Conundrum: Stoichiometric Disconnect between Its Formation and Oxidative Stress. Chem Res Toxicol. 2017 05 15; 30(5):1113-1116.
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Shpyleva S, Melnyk S, Pavliv O, Pogribny I, Jill James S. Overexpression of LINE-1 Retrotransposons in Autism Brain. Mol Neurobiol. 2018 02; 55(2):1740-1749.
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Hilgers RH, Kundumani-Sridharan V, Subramani J, Chen LC, Cuello LG, Rusch NJ, Das KC. Thioredoxin reverses age-related hypertension by chronically improving vascular redox and restoring eNOS function. Sci Transl Med. 2017 02 08; 9(376).
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Vargason T, Howsmon DP, Melnyk S, James SJ, Hahn J. Mathematical modeling of the methionine cycle and transsulfuration pathway in individuals with autism spectrum disorder. J Theor Biol. 2017 03 07; 416:28-37.
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Rose S, Bennuri SC, Wynne R, Melnyk S, James SJ, Frye RE. Mitochondrial and redox abnormalities in autism lymphoblastoid cells: a sibling control study. FASEB J. 2017 03; 31(3):904-909.
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Nunes J, Martins IL, Charneira C, Pogribny IP, de Conti A, Beland FA, Marques MM, Jacob CC, Antunes AMM. New insights into the molecular mechanisms of chemical carcinogenesis: In vivo adduction of histone H2B by a reactive metabolite of the chemical carcinogen furan. Toxicol Lett. 2016 Dec 15; 264:106-113.
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Bhushan B, Chavan H, Borude P, Xie Y, Du K, McGill MR, Lebofsky M, Jaeschke H, Krishnamurthy P, Apte U. Dual Role of Epidermal Growth Factor Receptor in Liver Injury and Regeneration after Acetaminophen Overdose in Mice. Toxicol Sci. 2017 02; 155(2):363-378.
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Subramani J, Kundumani-Sridharan V, Hilgers RH, Owens C, Das KC. Thioredoxin Uses a GSH-independent Route to Deglutathionylate Endothelial Nitric-oxide Synthase and Protect against Myocardial Infarction. J Biol Chem. 2016 Nov 04; 291(45):23374-23389.
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Banerjee S, Aykin-Burns N, Krager KJ, Shah SK, Melnyk SB, Hauer-Jensen M, Pawar SA. Loss of C/EBPd enhances IR-induced cell death by promoting oxidative stress and mitochondrial dysfunction. Free Radic Biol Med. 2016 10; 99:296-307.
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Savic D, Ramaker RC, Roberts BS, Dean EC, Burwell TC, Meadows SK, Cooper SJ, Garabedian MJ, Gertz J, Myers RM. Distinct gene regulatory programs define the inhibitory effects of liver X receptors and PPARG on cancer cell proliferation. Genome Med. 2016 07 11; 8(1):74.
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Shearn CT, Orlicky DJ, McCullough RL, Jiang H, Maclean KN, Mercer KE, Stiles BL, Saba LM, Ronis MJ, Petersen DR. Liver-Specific Deletion of Phosphatase and Tensin Homolog Deleted on Chromosome 10 Significantly Ameliorates Chronic EtOH-Induced Increases in Hepatocellular Damage. PLoS One. 2016; 11(4):e0154152.
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El-Ebiary AA, Elsharkawy RE, Soliman NA, Soliman MA, Hashem AA. N-acetylcysteine in Acute Organophosphorus Pesticide Poisoning: A Randomized, Clinical Trial. Basic Clin Pharmacol Toxicol. 2016 Aug; 119(2):222-7.
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Sappington DR, Siegel ER, Hiatt G, Desai A, Penney RB, Jamshidi-Parsian A, Griffin RJ, Boysen G. Glutamine drives glutathione synthesis and contributes to radiation sensitivity of A549 and H460 lung cancer cell lines. Biochim Biophys Acta. 2016 Apr; 1860(4):836-43.
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Zhang J, Doshi U, Suzuki A, Chang CW, Borlak J, Li AP, Tong W. Evaluation of multiple mechanism-based toxicity endpoints in primary cultured human hepatocytes for the identification of drugs with clinical hepatotoxicity: Results from 152 marketed drugs with known liver injury profiles. Chem Biol Interact. 2016 Aug 05; 255:3-11.
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Mcgill MR, Jaeschke H. A direct comparison of methods used to measure oxidized glutathione in biological samples: 2-vinylpyridine and N-ethylmaleimide. Toxicol Mech Methods. 2015; 25(8):589-95.
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Xie Y, McGill MR, Du K, Dorko K, Kumer SC, Schmitt TM, Ding WX, Jaeschke H. Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes. Toxicol Appl Pharmacol. 2015 Dec 01; 289(2):213-22.
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Ferdaoussi M, Dai X, Jensen MV, Wang R, Peterson BS, Huang C, Ilkayeva O, Smith N, Miller N, Hajmrle C, Spigelman AF, Wright RC, Plummer G, Suzuki K, Mackay JP, van de Bunt M, Gloyn AL, Ryan TE, Norquay LD, Brosnan MJ, Trimmer JK, Rolph TP, Kibbey RG, Manning Fox JE, Colmers WF, Shirihai OS, Neufer PD, Yeh ET, Newgard CB, MacDonald PE. Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional ? cells. J Clin Invest. 2015 Oct 01; 125(10):3847-60.
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Zhang W, Deng J, Sunkara M, Morris AJ, Wang C, St Clair D, Vore M. Loss of multidrug resistance-associated protein 1 potentiates chronic doxorubicin-induced cardiac dysfunction in mice. J Pharmacol Exp Ther. 2015 Nov; 355(2):280-7.
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Deng J, Coy D, Zhang W, Sunkara M, Morris AJ, Wang C, Chaiswing L, St Clair D, Vore M, Jungsuwadee P. Elevated glutathione is not sufficient to protect against doxorubicin-induced nuclear damage in heart in multidrug resistance-associated protein 1 (Mrp1/Abcc1) null mice. J Pharmacol Exp Ther. 2015 Nov; 355(2):272-9.
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Dan H, Zhang L, Qin X, Peng X, Wong M, Tan X, Yu S, Fang N. Moutan cortex extract exerts protective effects in a rat model of cardiac ischemia/reperfusion. Can J Physiol Pharmacol. 2016 Mar; 94(3):245-50.
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