 Hydrocortisone
"Hydrocortisone" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.
| Descriptor ID |
D006854
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| MeSH Number(s) |
D04.808.745.745.654.600 D06.472.040.585.353.476 D06.472.040.585.478.392
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Hydrocortisone".
Below are MeSH descriptors whose meaning is more specific than "Hydrocortisone".
This graph shows the total number of publications written about "Hydrocortisone" by people in UAMS Profiles by year, and whether "Hydrocortisone" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2022 | 0 | 2 | 2 | | 2021 | 0 | 1 | 1 | | 2020 | 0 | 3 | 3 | | 2019 | 2 | 3 | 5 | | 2018 | 4 | 2 | 6 | | 2017 | 9 | 9 | 18 | | 2016 | 3 | 2 | 5 | | 2015 | 3 | 2 | 5 | | 2014 | 4 | 3 | 7 | | 2013 | 4 | 4 | 8 | | 2012 | 3 | 4 | 7 | | 2011 | 3 | 4 | 7 | | 2010 | 3 | 6 | 9 | | 2009 | 5 | 0 | 5 | | 2008 | 1 | 1 | 2 | | 2007 | 2 | 4 | 6 | | 2006 | 4 | 3 | 7 | | 2005 | 1 | 1 | 2 | | 2004 | 2 | 3 | 5 | | 2003 | 1 | 0 | 1 | | 2002 | 0 | 1 | 1 | | 2001 | 0 | 2 | 2 | | 2000 | 2 | 4 | 6 | | 1999 | 0 | 3 | 3 | | 1998 | 1 | 2 | 3 | | 1997 | 0 | 2 | 2 | | 1996 | 1 | 0 | 1 | | 1994 | 1 | 0 | 1 | | 1992 | 1 | 0 | 1 | | 1991 | 1 | 1 | 2 | | 1990 | 0 | 2 | 2 | | 1989 | 1 | 2 | 3 |
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Below are the most recent publications written about "Hydrocortisone" by people in Profiles over the past ten years.
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Abernethie AJ, Gastaldello A, Maltese G, Morgan RA, McInnes KJ, Small GR, Walker BR, Livingstone DE, Hadoke PW, Andrew R. Comparison of mechanisms of angiostasis caused by the anti-inflammatory steroid 5a-tetrahydrocorticosterone versus conventional glucocorticoids. Eur J Pharmacol. 2022 Aug 15; 929:175111.
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al'Absi M, DeAngelis B, Fiecas M, Budney A, Allen S. Effects of regular cannabis and nicotine use on acute stress responses: chronic nicotine, but not cannabis use, is associated with blunted adrenocortical and cardiovascular responses to stress. Psychopharmacology (Berl). 2022 May; 239(5):1551-1561.
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Zayed Y, Alzghoul BN, Banifadel M, Venigandla H, Hyde R, Sutchu S, Khasawneh M, Borok Z, Urbine D, Jantz M, Reddy R. Vitamin C, Thiamine, and Hydrocortisone in the Treatment of Sepsis: A Meta-Analysis and Trial Sequential Analysis of Randomized Controlled Trials. J Intensive Care Med. 2022 Mar; 37(3):327-336.
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Hansen AL, Ambroziak G, Thornton D, Mundt JC, Kahn RE, Dahl L, Waage L, Kattenbraker D, Araujo P, Murison R, Rypdal K, Grung B. Vitamin D Supplementation during Winter: Effects on Stress Resilience in a Randomized Control Trial. Nutrients. 2020 Oct 24; 12(11).
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Gu C, Brereton N, Schweitzer A, Cotter M, Duan D, Børsheim E, Wolfe RR, Pham LV, Polotsky VY, Jun JC. Metabolic Effects of Late Dinner in Healthy Volunteers-A Randomized Crossover Clinical Trial. J Clin Endocrinol Metab. 2020 08 01; 105(8).
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Melvin A, Chantzichristos D, Kyle CJ, Mackenzie SD, Walker BR, Johannsson G, Stimson RH, O'Rahilly S. GDF15 Is Elevated in Conditions of Glucocorticoid Deficiency and Is Modulated by Glucocorticoid Replacement. J Clin Endocrinol Metab. 2020 05 01; 105(5).
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Crawford AA, Soderberg S, Kirschbaum C, Murphy L, Eliasson M, Ebrahim S, Davey Smith G, Olsson T, Sattar N, Lawlor DA, Timpson NJ, Reynolds RM, Walker BR. Morning plasma cortisol as a cardiovascular risk factor: findings from prospective cohort and Mendelian randomization studies. Eur J Endocrinol. 2019 Oct; 181(4):429-438.
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Vilke GM, Mash DC, Pardo M, Bozeman W, Hall C, Sloane C, Wilson MP, Coyne CJ, Xie X, Castillo EM. EXCITATION study: Unexplained in-custody deaths: Evaluating biomarkers of stress and agitation. J Forensic Leg Med. 2019 Aug; 66:100-106.
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Lovallo WR, Cohoon AJ, Sorocco KH, Vincent AS, Acheson A, Hodgkinson CA, Goldman D. Early-Life Adversity and Blunted Stress Reactivity as Predictors of Alcohol and Drug use in Persons With COMT (rs4680) Val158Met Genotypes. Alcohol Clin Exp Res. 2019 07; 43(7):1519-1527.
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Lovallo WR, Cohoon AJ, Acheson A, Vincent AS, Sorocco KH. Cortisol stress reactivity in women, diurnal variations, and hormonal contraceptives: studies from the Family Health Patterns Project. Stress. 2019 07; 22(4):421-427.
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Lowry M, Achanta L. Image Diagnosis: Aortic Thrombus in Severe Hypercortisolemia. Perm J. 2019; 23:18-167.
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Morgan RA, Keen JA, Homer N, Nixon M, McKinnon-Garvin AM, Moses-Williams JA, Davis SR, Hadoke PWF, Walker BR. Dysregulation of Cortisol Metabolism in Equine Pituitary Pars Intermedia Dysfunction. Endocrinology. 2018 11 01; 159(11):3791-3800.
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Lovallo WR, Acheson A, Vincent AS, Sorocco KH, Cohoon AJ. Early life adversity diminishes the cortisol response to opioid blockade in women: Studies from the Family Health Patterns project. PLoS One. 2018; 13(10):e0205723.
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Hernández LM, Markwald RR, Kviatkovsky SA, Perry LN, Taylor MK. Morning Cortisol Is Associated With Stress and Sleep in Elite Military Men: A Brief Report. Mil Med. 2018 09 01; 183(9-10):e255-e259.
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Swales DA, Winiarski DA, Smith AK, Stowe ZN, Newport DJ, Brennan PA. Maternal depression and cortisol in pregnancy predict offspring emotional reactivity in the preschool period. Dev Psychobiol. 2018 07; 60(5):557-566.
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Laurent H, Goodman SH, Stowe ZN, Halperin M, Khan F, Wright D, Nelson BW, Newport DJ, Ritchie JC, Monk C, Knight B. Course of ante- and postnatal depressive symptoms related to mothers' HPA axis regulation. J Abnorm Psychol. 2018 05; 127(4):404-416.
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Hawcutt DB, Francis B, Carr DF, Jorgensen AL, Yin P, Wallin N, O'Hara N, Zhang EJ, Bloch KM, Ganguli A, Thompson B, McEvoy L, Peak M, Crawford AA, Walker BR, Blair JC, Couriel J, Smyth RL, Pirmohamed M. Susceptibility to corticosteroid-induced adrenal suppression: a genome-wide association study. Lancet Respir Med. 2018 06; 6(6):442-450.
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Annane D, Pastores SM, Arlt W, Balk RA, Beishuizen A, Briegel J, Carcillo J, Christ-Crain M, Cooper MS, Marik PE, Meduri GU, Olsen KM, Rochwerg B, Rodgers SC, Russell JA, Van den Berghe G. Critical Illness-Related Corticosteroid Insufficiency (CIRCI): A Narrative Review from a Multispecialty Task Force of the Society of Critical Care Medicine (SCCM) and the European Society of Intensive Care Medicine (ESICM). Crit Care Med. 2017 Dec; 45(12):2089-2098.
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Annane D, Pastores SM, Rochwerg B, Arlt W, Balk RA, Beishuizen A, Briegel J, Carcillo J, Christ-Crain M, Cooper MS, Marik PE, Umberto Meduri G, Olsen KM, Rodgers SC, Russell JA, Van den Berghe G. Guidelines for the Diagnosis and Management of Critical Illness-Related Corticosteroid Insufficiency (CIRCI) in Critically Ill Patients (Part I): Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) 2017. Crit Care Med. 2017 Dec; 45(12):2078-2088.
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Rietschel L, Streit F, Zhu G, McAloney K, Frank J, Couvy-Duchesne B, Witt SH, Binz TM, McGrath J, Hickie IB, Hansell NK, Wright MJ, Gillespie NA, Forstner AJ, Schulze TG, Wüst S, Nöthen MM, Baumgartner MR, Walker BR, Crawford AA, Colodro-Conde L, Medland SE, Martin NG, Rietschel M. Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes. Sci Rep. 2017 11 10; 7(1):15351.
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van Zwol A, Oosterloo NBC, de Betue CT, Bogers A, de Liefde II, Deutz NEP, Joosten KFM. Effects of glucocorticoids on serum amino acid levels during cardiac surgery in children. Clin Nutr ESPEN. 2018 02; 23:212-216.
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Annane D, Pastores SM, Rochwerg B, Arlt W, Balk RA, Beishuizen A, Briegel J, Carcillo J, Christ-Crain M, Cooper MS, Marik PE, Umberto Meduri G, Olsen KM, Rodgers S, Russell JA, Van den Berghe G. Guidelines for the diagnosis and management of critical illness-related corticosteroid insufficiency (CIRCI) in critically ill patients (Part I): Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) 2017. Intensive Care Med. 2017 Dec; 43(12):1751-1763.
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Annane D, Pastores SM, Arlt W, Balk RA, Beishuizen A, Briegel J, Carcillo J, Christ-Crain M, Cooper MS, Marik PE, Meduri GU, Olsen KM, Rochwerg B, Rodgers SC, Russell JA, Van den Berghe G. Critical illness-related corticosteroid insufficiency (CIRCI): a narrative review from a Multispecialty Task Force of the Society of Critical Care Medicine (SCCM) and the European Society of Intensive Care Medicine (ESICM). Intensive Care Med. 2017 Dec; 43(12):1781-1792.
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Hendrix CL, Stowe ZN, Newport DJ, Brennan PA. Physiological attunement in mother-infant dyads at clinical high risk: The influence of maternal depression and positive parenting. Dev Psychopathol. 2018 05; 30(2):623-634.
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Morgan RA, Beck KR, Nixon M, Homer NZM, Crawford AA, Melchers D, Houtman R, Meijer OC, Stomby A, Anderson AJ, Upreti R, Stimson RH, Olsson T, Michoel T, Cohain A, Ruusalepp A, Schadt EE, Björkegren JLM, Andrew R, Kenyon CJ, Hadoke PWF, Odermatt A, Keen JA, Walker BR. Carbonyl reductase 1 catalyzes 20ß-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity. Sci Rep. 2017 09 06; 7(1):10633.
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Chopra S, Rathore A, Younas H, Pham LV, Gu C, Beselman A, Kim IY, Wolfe RR, Perin J, Polotsky VY, Jun JC. Obstructive Sleep Apnea Dynamically Increases Nocturnal Plasma Free Fatty Acids, Glucose, and Cortisol During Sleep. J Clin Endocrinol Metab. 2017 09 01; 102(9):3172-3181.
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Neumann A, Direk N, Crawford AA, Mirza S, Adams H, Bolton J, Hayward C, Strachan DP, Payne EK, Smith JA, Milaneschi Y, Penninx B, Hottenga JJ, de Geus E, Oldehinkel AJ, van der Most PJ, de Rijke Y, Walker BR, Tiemeier H. The low single nucleotide polymorphism heritability of plasma and saliva cortisol levels. Psychoneuroendocrinology. 2017 Nov; 85:88-95.
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Lovallo WR, Enoch MA, Sorocco KH, Vincent AS, Acheson A, Cohoon AJ, Hodgkinson CA, Goldman D. Joint Impact of Early Life Adversity and COMT Val158Met (rs4680) Genotypes on the Adult Cortisol Response to Psychological Stress. Psychosom Med. 2017 Jul/Aug; 79(6):631-637.
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Frost A, Jelinek C, Bernard K, Lind T, Dozier M. Longitudinal associations between low morning cortisol in infancy and anger dysregulation in early childhood in a CPS-referred sample. Dev Sci. 2018 May; 21(3):e12573.
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Taylor MK, Hernández LM, Kviatkovsky SA, Schoenherr MR, Stone MS, Sargent P. The "yin and yang" of the adrenal and gonadal systems in elite military men. Stress. 2017 05; 20(3):258-264.
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Johnson EC, Bardis CN, Jansen LT, Adams JD, Kirkland TW, Kavouras SA. Reduced water intake deteriorates glucose regulation in patients with type 2 diabetes. Nutr Res. 2017 Jul; 43:25-32.
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Bartolomei S, Sadres E, Church DD, Arroyo E, Gordon JA, Varanoske AN, Wang R, Beyer KS, Oliveira LP, Stout JR, Hoffman JR. Comparison of the recovery response from high-intensity and high-volume resistance exercise in trained men. Eur J Appl Physiol. 2017 07; 117(7):1287-1298.
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Trexler ET, Hirsch KR, Campbell BI, Smith-Ryan AE. Physiological Changes Following Competition in Male and Female Physique Athletes: A Pilot Study. Int J Sport Nutr Exerc Metab. 2017 Oct; 27(5):458-466.
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Joehlin-Price AS, Hardesty DA, Arnold CA, Kirschner LS, Prevedello DM, Lehman NL. Case report: ACTH-secreting pituitary carcinoma metastatic to the liver in a patient with a history of atypical pituitary adenoma and Cushing's disease. Diagn Pathol. 2017 Apr 18; 12(1):34.
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Webster SP, McBride A, Binnie M, Sooy K, Seckl JR, Andrew R, Pallin TD, Hunt HJ, Perrior TR, Ruffles VS, Ketelbey JW, Boyd A, Walker BR. Selection and early clinical evaluation of the brain-penetrant 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitor UE2343 (Xanamem™). Br J Pharmacol. 2017 03; 174(5):396-408.
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Anderson AJ, Andrew R, Homer NZ, Jones GC, Smith K, Livingstone DE, Walker BR, Stimson RH. Metformin Increases Cortisol Regeneration by 11ßHSD1 in Obese Men With and Without Type 2 Diabetes Mellitus. J Clin Endocrinol Metab. 2016 10; 101(10):3787-3793.
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Wells AJ, Hoffman JR, Jajtner AR, Varanoske AN, Church DD, Gonzalez AM, Townsend JR, Boone CH, Baker KM, Beyer KS, Mangine GT, Oliveira LP, Fukuda DH, Stout JR. The Effect of Post-Resistance Exercise Amino Acids on Plasma MCP-1 and CCR2 Expression. Nutrients. 2016 Jul 02; 8(7).
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Wells AJ, Hoffman JR, Jajtner AR, Varanoske AN, Church DD, Gonzalez AM, Townsend JR, Boone CH, Baker KM, Beyer KS, Mangine GT, Oliveira LP, Fukuda DH, Stout JR. Monocyte Recruitment after High-Intensity and High-Volume Resistance Exercise. Med Sci Sports Exerc. 2016 06; 48(6):1169-78.
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Taylor MK, Kviatkovsky SA, Hernández LM, Sargent P, Segal S, Granger DA. Anabolic hormone profiles in elite military men. Steroids. 2016 06; 110:41-48.
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Nakamura Y, Walker BR, Ikuta T. Systematic review and meta-analysis reveals acutely elevated plasma cortisol following fasting but not less severe calorie restriction. Stress. 2016; 19(2):151-7.
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Lovallo WR, Enoch MA, Acheson A, Cohoon AJ, Sorocco KH, Hodgkinson CA, Vincent AS, Goldman D. Early-Life Adversity Interacts with FKBP5 Genotypes: Altered Working Memory and Cardiac Stress Reactivity in the Oklahoma Family Health Patterns Project. Neuropsychopharmacology. 2016 06; 41(7):1724-32.
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Stirrat LI, O'Reilly JR, Barr SM, Andrew R, Riley SC, Howie AF, Bowman M, Smith R, Lewis JG, Denison FC, Forbes S, Seckl JR, Walker BR, Norman JE, Reynolds RM. Decreased maternal hypothalamic-pituitary-adrenal axis activity in very severely obese pregnancy: Associations with birthweight and gestation at delivery. Psychoneuroendocrinology. 2016 Jan; 63:135-43.
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Gonzalez AM, Hoffman JR, Jajtner AR, Townsend JR, Boone CH, Beyer KS, Baker KM, Wells AJ, Church DD, Mangine GT, Oliveira LP, Moon JR, Fukuda DH, Stout JR. Protein supplementation does not alter intramuscular anabolic signaling or endocrine response after resistance exercise in trained men. Nutr Res. 2015 Nov; 35(11):990-1000.
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Juul SH, Hendrix C, Robinson B, Stowe ZN, Newport DJ, Brennan PA, Johnson KC. Maternal early-life trauma and affective parenting style: the mediating role of HPA-axis function. Arch Womens Ment Health. 2016 Feb; 19(1):17-23.
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Lovallo WR, Enoch MA, Acheson A, Cohoon AJ, Sorocco KH, Hodgkinson CA, Vincent AS, Glahn DC, Goldman D. Cortisol Stress Response in Men and Women Modulated Differentially by the Mu-Opioid Receptor Gene Polymorphism OPRM1 A118G. Neuropsychopharmacology. 2015 Oct; 40(11):2546-54.
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Kilgour AH, Semple S, Marshall I, Andrews P, Andrew R, Walker BR. 11ß-Hydroxysteroid dehydrogenase activity in the brain does not contribute to systemic interconversion of cortisol and cortisone in healthy men. J Clin Endocrinol Metab. 2015 Feb; 100(2):483-9.
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Com G, Uc A. Exercise intolerance, malnutrition, abnormal sweat chloride levels, and two CFTR mutations: is it cystic fibrosis? J Pediatr Health Care. 2015 Mar-Apr; 29(2):201-4.
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Rios DR, Moffett BS, Kaiser JR. Trends in pharmacotherapy for neonatal hypotension. J Pediatr. 2014 Oct; 165(4):697-701.e1.
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Bolton JL, Hayward C, Direk N, Lewis JG, Hammond GL, Hill LA, Anderson A, Huffman J, Wilson JF, Campbell H, Rudan I, Wright A, Hastie N, Wild SH, Velders FP, Hofman A, Uitterlinden AG, Lahti J, Räikkönen K, Kajantie E, Widen E, Palotie A, Eriksson JG, Kaakinen M, Järvelin MR, Timpson NJ, Davey Smith G, Ring SM, Evans DM, St Pourcain B, Tanaka T, Milaneschi Y, Bandinelli S, Ferrucci L, van der Harst P, Rosmalen JG, Bakker SJ, Verweij N, Dullaart RP, Mahajan A, Lindgren CM, Morris A, Lind L, Ingelsson E, Anderson LN, Pennell CE, Lye SJ, Matthews SG, Eriksson J, Mellstrom D, Ohlsson C, Price JF, Strachan MW, Reynolds RM, Tiemeier H, Walker BR. Genome wide association identifies common variants at the SERPINA6/SERPINA1 locus influencing plasma cortisol and corticosteroid binding globulin. PLoS Genet. 2014 Jul; 10(7):e1004474.
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Gambineri A, Fanelli F, Tomassoni F, Munarini A, Pagotto U, Andrew R, Walker BR, Pasquali R. Tissue-specific dysregulation of 11ß-hydroxysteroid dehydrogenase type 1 in overweight/obese women with polycystic ovary syndrome compared with weight-matched controls. Eur J Endocrinol. 2014 Jul; 171(1):47-57.
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Walker BR, Andrew R, Escoubet B, Zennaro MC. Activation of the hypothalamic-pituitary-adrenal axis in adults with mineralocorticoid receptor haploinsufficiency. J Clin Endocrinol Metab. 2014 Aug; 99(8):E1586-91.
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Neu M, Matthews E, King NA, Cook PF, Laudenslager ML. Anxiety, depression, stress, and cortisol levels in mothers of children undergoing maintenance therapy for childhood acute lymphoblastic leukemia. J Pediatr Oncol Nurs. 2014 Mar-Apr; 31(2):104-13.
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Sumner JA, McLaughlin KA, Walsh K, Sheridan MA, Koenen KC. CRHR1 genotype and history of maltreatment predict cortisol reactivity to stress in adolescents. Psychoneuroendocrinology. 2014 May; 43:71-80.
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Kilgour AH, Gallagher IJ, MacLullich AM, Andrew R, Gray CD, Hyde P, Wackerhage H, Husi H, Ross JA, Starr JM, Chapman KE, Fearon KC, Walker BR, Greig CA. Increased skeletal muscle 11ßHSD1 mRNA is associated with lower muscle strength in ageing. PLoS One. 2013; 8(12):e84057.
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Stimson RH, Mohd-Shukri NA, Bolton JL, Andrew R, Reynolds RM, Walker BR. The postprandial rise in plasma cortisol in men is mediated by macronutrient-specific stimulation of adrenal and extra-adrenal cortisol production. J Clin Endocrinol Metab. 2014 Jan; 99(1):160-168.
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Papoiu AD, Valdes-Rodriguez R, Nattkemper LA, Chan YH, Hahn GS, Yosipovitch G. A novel topical formulation containing strontium chloride significantly reduces the intensity and duration of cowhage-induced itch. Acta Derm Venereol. 2013 Sep 04; 93(5):520-6.
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MacDonald K, MacDonald TM, Brüne M, Lamb K, Wilson MP, Golshan S, Feifel D. Oxytocin and psychotherapy: a pilot study of its physiological, behavioral and subjective effects in males with depression. Psychoneuroendocrinology. 2013 Dec; 38(12):2831-43.
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Tao Y, Gao L, Wu X, Wang H, Yang G, Zhan F, Shi J. Down-regulation of 11ß-hydroxysteroid dehydrogenase type 2 by bortezomib sensitizes Jurkat leukemia T cells against glucocorticoid-induced apoptosis. PLoS One. 2013; 8(6):e67067.
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