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Tudor Moldoveanu

TitleAssociate Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentCOM | Biochemistry & Molecular Biology
Address4301 W Markham
Little Rock AR 72205
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Sekar G, Ojoawo A, Moldoveanu T. Protein-protein and protein-lipid interactions of pore-forming BCL-2 family proteins in apoptosis initiation. Biochem Soc Trans. 2022 06 30; 50(3):1091-1103. PMID: 35521828.
      View in: PubMed
    2. Singh G, Guibao CD, Seetharaman J, Aggarwal A, Grace CR, McNamara DE, Vaithiyalingam S, Waddell MB, Moldoveanu T. Structural basis of BAK activation in mitochondrial apoptosis initiation. Nat Commun. 2022 01 11; 13(1):250. PMID: 35017502.
      View in: PubMed
    3. Ojoawo AM, Moldoveanu T. A killer metamorphosis: catching BAK in action at the membrane. EMBO J. 2021 10 18; 40(20):e109529. PMID: 34542920.
      View in: PubMed
    4. Schnetler R, Fanucchi S, Moldoveanu T, Koorsen G. Linker Histone H1.2 Directly Activates BAK through the K/RVVKP Motif on the C-Terminal Domain. Biochemistry. 2020 09 15; 59(36):3332-3346. PMID: 32786407.
      View in: PubMed
    5. Moldoveanu T, Czabotar PE. BAX, BAK, and BOK: A Coming of Age for the BCL-2 Family Effector Proteins. Cold Spring Harb Perspect Biol. 2020 04 01; 12(4). PMID: 31570337.
      View in: PubMed
    6. Guibao CD, Petrinjak K, Moldoveanu T. Uncovering human mixed lineage kinase domain-like activation in necroptosis. Future Med Chem. 2019 11; 11(21):2831-2844. PMID: 31713433.
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    7. McNamara DE, Dovey CM, Hale AT, Quarato G, Grace CR, Guibao CD, Diep J, Nourse A, Cai CR, Wu H, Kalathur RC, Green DR, York JD, Carette JE, Moldoveanu T. Direct Activation of Human MLKL by a Select Repertoire of Inositol Phosphate Metabolites. Cell Chem Biol. 2019 06 20; 26(6):863-877.e7. PMID: 31031142.
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    8. Singh G, Moldoveanu T. Methods to Probe Conformational Activation and Mitochondrial Activity of Proapoptotic BAK. Methods Mol Biol. 2019; 1877:185-200. PMID: 30536007.
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    9. McNamara DE, Quarato G, Guy CS, Green DR, Moldoveanu T. Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis. J Vis Exp. 2018 08 07; (138). PMID: 30148498.
      View in: PubMed
    10. Moldoveanu T, Zheng JH. Metastability, an emerging concept governing BOK-mediated apoptosis initiation. Oncotarget. 2018 Jul 24; 9(57):30944-30945. PMID: 30123418.
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    11. Dovey CM, Diep J, Clarke BP, Hale AT, McNamara DE, Guo H, Brown NW, Cao JY, Grace CR, Gough PJ, Bertin J, Dixon SJ, Fiedler D, Mocarski ES, Kaiser WJ, Moldoveanu T, York JD, Carette JE. MLKL Requires the Inositol Phosphate Code to Execute Necroptosis. Mol Cell. 2018 06 07; 70(5):936-948.e7. PMID: 29883610.
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    12. Zheng JH, Grace CR, Guibao CD, McNamara DE, Llambi F, Wang YM, Chen T, Moldoveanu T. Intrinsic Instability of BOK Enables Membrane Permeabilization in Apoptosis. Cell Rep. 2018 05 15; 23(7):2083-2094.e6. PMID: 29768206.
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    13. Ponnusamy S, Coss CC, Thiyagarajan T, Watts K, Hwang DJ, He Y, Selth LA, McEwan IJ, Duke CB, Pagadala J, Singh G, Wake RW, Ledbetter C, Tilley WD, Moldoveanu T, Dalton JT, Miller DD, Narayanan R. Novel Selective Agents for the Degradation of Androgen Receptor Variants to Treat Castration-Resistant Prostate Cancer. Cancer Res. 2017 11 15; 77(22):6282-6298. PMID: 28978635.
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    14. Wu X, Zhang LS, Toombs J, Kuo YC, Piazza JT, Tuladhar R, Barrett Q, Fan CW, Zhang X, Walensky LD, Kool M, Cheng SY, Brekken R, Opferman JT, Green DR, Moldoveanu T, Lum L. Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor. Nat Cell Biol. 2017 Oct; 19(10):1226-1236. PMID: 28945232.
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    15. Llambi F, Wang YM, Victor B, Yang M, Schneider DM, Gingras S, Parsons MJ, Zheng JH, Brown SA, Pelletier S, Moldoveanu T, Chen T, Green DR. BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation. Cell. 2016 Apr 07; 165(2):421-33. PMID: 26949185.
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    16. Quarato G, Guy CS, Grace CR, Llambi F, Nourse A, Rodriguez DA, Wakefield R, Frase S, Moldoveanu T, Green DR. Sequential Engagement of Distinct MLKL Phosphatidylinositol-Binding Sites Executes Necroptosis. Mol Cell. 2016 Feb 18; 61(4):589-601. PMID: 26853145.
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    17. Zheng JH, Viacava Follis A, Kriwacki RW, Moldoveanu T. Discoveries and controversies in BCL-2 protein-mediated apoptosis. FEBS J. 2016 07; 283(14):2690-700. PMID: 26411300.
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    18. Moldoveanu T, Follis AV, Kriwacki RW, Green DR. Many players in BCL-2 family affairs. Trends Biochem Sci. 2014 Mar; 39(3):101-11. PMID: 24503222.
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    19. McCoy F, Darbandi R, Lee HC, Bharatham K, Moldoveanu T, Grace CR, Dodd K, Lin W, Chen SI, Tangallapally RP, Kurokawa M, Lee RE, Shelat AA, Chen T, Green DR, Harris RA, Lin SH, Fissore RA, Colbran RJ, Nutt LK. Metabolic activation of CaMKII by coenzyme A. Mol Cell. 2013 Nov 07; 52(3):325-39. PMID: 24095281.
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    20. Moldoveanu T, Grace CR, Llambi F, Nourse A, Fitzgerald P, Gehring K, Kriwacki RW, Green DR. BID-induced structural changes in BAK promote apoptosis. Nat Struct Mol Biol. 2013 May; 20(5):589-97. PMID: 23604079.
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    21. Llambi F, Moldoveanu T, Tait SW, Bouchier-Hayes L, Temirov J, McCormick LL, Dillon CP, Green DR. A unified model of mammalian BCL-2 protein family interactions at the mitochondria. Mol Cell. 2011 Nov 18; 44(4):517-31. PMID: 22036586.
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    22. Du H, Wolf J, Schafer B, Moldoveanu T, Chipuk JE, Kuwana T. BH3 domains other than Bim and Bid can directly activate Bax/Bak. J Biol Chem. 2011 Jan 07; 286(1):491-501. PMID: 21041309.
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    23. Koyanagi M, Kerns JA, Chung L, Zhang Y, Brown S, Moldoveanu T, Malik HS, Bix M. Diversifying selection and functional analysis of interleukin-4 suggests antagonism-driven evolution at receptor-binding interfaces. BMC Evol Biol. 2010 Jul 22; 10:223. PMID: 20649995.
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    24. Liu Q, Moldoveanu T, Sprules T, Matta-Camacho E, Mansur-Azzam N, Gehring K. Apoptotic regulation by MCL-1 through heterodimerization. J Biol Chem. 2010 Jun 18; 285(25):19615-24. PMID: 20392693.
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    25. Chipuk JE, Moldoveanu T, Llambi F, Parsons MJ, Green DR. The BCL-2 family reunion. Mol Cell. 2010 Feb 12; 37(3):299-310. PMID: 20159550.
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    26. Moldoveanu T, Gehring K, Green DR. Concerted multi-pronged attack by calpastatin to occlude the catalytic cleft of heterodimeric calpains. Nature. 2008 Nov 20; 456(7220):404-8. PMID: 19020622.
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    27. Kozlov G, Peschard P, Zimmerman B, Lin T, Moldoveanu T, Mansur-Azzam N, Gehring K, Park M. Structural basis for UBA-mediated dimerization of c-Cbl ubiquitin ligase. J Biol Chem. 2007 Sep 14; 282(37):27547-27555. PMID: 17635922.
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    28. Cuerrier D, Moldoveanu T, Campbell RL, Kelly J, Yoruk B, Verhelst SHL, Greenbaum D, Bogyo M, Davies PL. Development of calpain-specific inactivators by screening of positional scanning epoxide libraries. J Biol Chem. 2007 Mar 30; 282(13):9600-9611. PMID: 17218315.
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    29. Moldoveanu T, Liu Q, Tocilj A, Watson M, Shore G, Gehring K. The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site. Mol Cell. 2006 Dec 08; 24(5):677-688. PMID: 17157251.
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    30. Cuerrier D, Moldoveanu T, Inoue J, Davies PL, Campbell RL. Calpain inhibition by alpha-ketoamide and cyclic hemiacetal inhibitors revealed by X-ray crystallography. Biochemistry. 2006 Jun 20; 45(24):7446-52. PMID: 16768440.
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    31. Denisov AY, Chen G, Sprules T, Moldoveanu T, Beauparlant P, Gehring K. Structural model of the BCL-w-BID peptide complex and its interactions with phospholipid micelles. Biochemistry. 2006 Feb 21; 45(7):2250-6. PMID: 16475813.
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    32. Cuerrier D, Moldoveanu T, Davies PL. Determination of peptide substrate specificity for mu-calpain by a peptide library-based approach: the importance of primed side interactions. J Biol Chem. 2005 Dec 09; 280(49):40632-41. PMID: 16216885.
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    33. Moldoveanu T, Campbell RL, Cuerrier D, Davies PL. Crystal structures of calpain-E64 and -leupeptin inhibitor complexes reveal mobile loops gating the active site. J Mol Biol. 2004 Nov 05; 343(5):1313-26. PMID: 15491615.
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    34. Diaz BG, Moldoveanu T, Kuiper MJ, Campbell RL, Davies PL. Insertion sequence 1 of muscle-specific calpain, p94, acts as an internal propeptide. J Biol Chem. 2004 Jun 25; 279(26):27656-66. PMID: 15073171.
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    35. Moldoveanu T, Jia Z, Davies PL. Calpain activation by cooperative Ca2+ binding at two non-EF-hand sites. J Biol Chem. 2004 Feb 13; 279(7):6106-14. PMID: 14581465.
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    36. Moldoveanu T, Hosfield CM, Lim D, Jia Z, Davies PL. Calpain silencing by a reversible intrinsic mechanism. Nat Struct Biol. 2003 May; 10(5):371-8. PMID: 12665854.
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    37. Moldoveanu T, Hosfield CM, Lim D, Elce JS, Jia Z, Davies PL. A Ca(2+) switch aligns the active site of calpain. Cell. 2002 Mar 08; 108(5):649-60. PMID: 11893336.
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    38. Jia Z, Petrounevitch V, Wong A, Moldoveanu T, Davies PL, Elce JS, Beckmann JS. Mutations in calpain 3 associated with limb girdle muscular dystrophy: analysis by molecular modeling and by mutation in m-calpain. Biophys J. 2001 Jun; 80(6):2590-6. PMID: 11371436.
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    39. Moldoveanu T, Hosfield CM, Jia Z, Elce JS, Davies PL. Ca(2+)-induced structural changes in rat m-calpain revealed by partial proteolysis. Biochim Biophys Acta. 2001 Feb 09; 1545(1-2):245-54. PMID: 11342050.
      View in: PubMed
    40. Hosfield CM, Moldoveanu T, Davies PL, Elce JS, Jia Z. Calpain mutants with increased Ca2+ sensitivity and implications for the role of the C(2)-like domain. J Biol Chem. 2001 Mar 09; 276(10):7404-7. PMID: 11102442.
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