 Glutamine
"Glutamine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from GLUTAMIC ACID and AMMONIA. It is the principal carrier of NITROGEN in the body and is an important energy source for many cells.
| Descriptor ID |
D005973
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| MeSH Number(s) |
D12.125.068.330 D12.125.095.461 D12.125.154.424
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Glutamine".
Below are MeSH descriptors whose meaning is more specific than "Glutamine".
This graph shows the total number of publications written about "Glutamine" by people in UAMS Profiles by year, and whether "Glutamine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2020 | 0 | 2 | 2 | | 2019 | 1 | 2 | 3 | | 2017 | 2 | 2 | 4 | | 2016 | 1 | 2 | 3 | | 2015 | 1 | 1 | 2 | | 2014 | 1 | 0 | 1 | | 2013 | 3 | 2 | 5 | | 2012 | 1 | 0 | 1 | | 2011 | 2 | 1 | 3 | | 2010 | 3 | 0 | 3 | | 2009 | 6 | 1 | 7 | | 2008 | 7 | 2 | 9 | | 2007 | 4 | 3 | 7 | | 2006 | 5 | 1 | 6 | | 2005 | 1 | 1 | 2 | | 2004 | 5 | 1 | 6 | | 2003 | 7 | 2 | 9 | | 2002 | 1 | 1 | 2 | | 2001 | 0 | 1 | 1 | | 2000 | 1 | 2 | 3 | | 1999 | 4 | 1 | 5 | | 1998 | 3 | 2 | 5 | | 1997 | 4 | 0 | 4 | | 1996 | 4 | 2 | 6 | | 1995 | 2 | 0 | 2 | | 1994 | 3 | 1 | 4 | | 1993 | 8 | 1 | 9 | | 1992 | 7 | 0 | 7 | | 1991 | 0 | 1 | 1 | | 1990 | 9 | 0 | 9 |
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Below are the most recent publications written about "Glutamine" by people in Profiles over the past ten years.
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Kutanzi KR, Ewing LE, Skinner CM, Quick CM, Kennon-McGill S, McGill MR, Walker LA, ElSohly MA, Gurley BJ, Koturbash I. Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Extract and Methylsulfonylmethane Co-Administration. Int J Mol Sci. 2020 Oct 21; 21(20).
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Dienel GA, Rothman DL. Reevaluation of Astrocyte-Neuron Energy Metabolism with Astrocyte Volume Fraction Correction: Impact on Cellular Glucose Oxidation Rates, Glutamate-Glutamine Cycle Energetics, Glycogen Levels and Utilization Rates vs. Exercising Muscle, and Na+/K+ Pumping Rates. Neurochem Res. 2020 Nov; 45(11):2607-2630.
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Du K, Chitneni SK, Suzuki A, Wang Y, Henao R, Hyun J, Premont RT, Naggie S, Moylan CA, Bashir MR, Abdelmalek MF, Diehl AM. Increased Glutaminolysis Marks Active Scarring in Nonalcoholic Steatohepatitis Progression. Cell Mol Gastroenterol Hepatol. 2020; 10(1):1-21.
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Boysen G, Jamshidi-Parsian A, Davis MA, Siegel ER, Simecka CM, Kore RA, Dings RPM, Griffin RJ. Glutaminase inhibitor CB-839 increases radiation sensitivity of lung tumor cells and human lung tumor xenografts in mice. Int J Radiat Biol. 2019 04; 95(4):436-442.
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Rothman DL, Dienel GA. Development of a Model to Test Whether Glycogenolysis Can Support Astrocytic Energy Demands of Na+, K+-ATPase and Glutamate-Glutamine Cycling, Sparing an Equivalent Amount of Glucose for Neurons. Adv Neurobiol. 2019; 23:385-433.
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Emadi A, Law JY, Strovel ET, Lapidus RG, Jeng LJB, Lee M, Blitzer MG, Carter-Cooper BA, Sewell D, Van Der Merwe I, Philip S, Imran M, Yu SL, Li H, Amrein PC, Duong VH, Sausville EA, Baer MR, Fathi AT, Singh Z, Bentzen SM. Asparaginase Erwinia chrysanthemi effectively depletes plasma glutamine in adult patients with relapsed/refractory acute myeloid leukemia. Cancer Chemother Pharmacol. 2018 01; 81(1):217-222.
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van Zwol A, Oosterloo NBC, de Betue CT, Bogers A, de Liefde II, Deutz NEP, Joosten KFM. Effects of glucocorticoids on serum amino acid levels during cardiac surgery in children. Clin Nutr ESPEN. 2018 02; 23:212-216.
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Romero R, Sayin VI, Davidson SM, Bauer MR, Singh SX, LeBoeuf SE, Karakousi TR, Ellis DC, Bhutkar A, Sánchez-Rivera FJ, Subbaraj L, Martinez B, Bronson RT, Prigge JR, Schmidt EE, Thomas CJ, Goparaju C, Davies A, Dolgalev I, Heguy A, Allaj V, Poirier JT, Moreira AL, Rudin CM, Pass HI, Vander Heiden MG, Jacks T, Papagiannakopoulos T. Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis. Nat Med. 2017 Nov; 23(11):1362-1368.
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Engelen MPKJ, Klimberg VS, Allasia A, Deutz NEP. Major surgery diminishes systemic arginine availability and suppresses nitric oxide response to feeding in patients with early stage breast cancer. Clin Nutr. 2018 10; 37(5):1645-1653.
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Hakvoort TB, He Y, Kulik W, Vermeulen JL, Duijst S, Ruijter JM, Runge JH, Deutz NE, Koehler SE, Lamers WH. Pivotal role of glutamine synthetase in ammonia detoxification. Hepatology. 2017 01; 65(1):281-293.
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Millichap JJ, Miceli F, De Maria M, Keator C, Joshi N, Tran B, Soldovieri MV, Ambrosino P, Shashi V, Mikati MA, Cooper EC, Taglialatela M. Infantile spasms and encephalopathy without preceding neonatal seizures caused by KCNQ2 R198Q, a gain-of-function variant. Epilepsia. 2017 01; 58(1):e10-e15.
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Sappington DR, Siegel ER, Hiatt G, Desai A, Penney RB, Jamshidi-Parsian A, Griffin RJ, Boysen G. Glutamine drives glutathione synthesis and contributes to radiation sensitivity of A549 and H460 lung cancer cell lines. Biochim Biophys Acta. 2016 Apr; 1860(4):836-43.
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Ligthart-Melis GC, Marini JC, Engelen MP, Deutz NE. Glutamine supplementation, citrulline production, and de novo arginine synthesis: is there a relation? Am J Clin Nutr. 2015 Apr; 101(4):890-2.
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Samanta D, Ramakrishnaiah R. De novo R853Q mutation of SCN2A gene and West syndrome. Acta Neurol Belg. 2015 Dec; 115(4):773-6.
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Zuhl M, Dokladny K, Mermier C, Schneider S, Salgado R, Moseley P. The effects of acute oral glutamine supplementation on exercise-induced gastrointestinal permeability and heat shock protein expression in peripheral blood mononuclear cells. Cell Stress Chaperones. 2015 Jan; 20(1):85-93.
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Terunuma A, Putluri N, Mishra P, Mathé EA, Dorsey TH, Yi M, Wallace TA, Issaq HJ, Zhou M, Killian JK, Stevenson HS, Karoly ED, Chan K, Samanta S, Prieto D, Hsu TY, Kurley SJ, Putluri V, Sonavane R, Edelman DC, Wulff J, Starks AM, Yang Y, Kittles RA, Yfantis HG, Lee DH, Ioffe OB, Schiff R, Stephens RM, Meltzer PS, Veenstra TD, Westbrook TF, Sreekumar A, Ambs S. MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis. J Clin Invest. 2014 Jan; 124(1):398-412.
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Zuhl MN, Lanphere KR, Kravitz L, Mermier CM, Schneider S, Dokladny K, Moseley PL. Effects of oral glutamine supplementation on exercise-induced gastrointestinal permeability and tight junction protein expression. J Appl Physiol (1985). 2014 Jan 15; 116(2):183-91.
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Gibran NS, Wiechman S, Meyer W, Edelman L, Fauerbach J, Gibbons L, Holavanahalli R, Hunt C, Keller K, Kirk E, Laird J, Lewis G, Moses S, Sproul J, Wilkinson G, Wolf S, Young A, Yovino S, Mosier MJ, Cancio LC, Amani H, Blayney C, Cullinane J, Haith L, Jeng JC, Kardos P, Kramer G, Lawless MB, Serio-Melvin ML, Miller S, Moran K, Novakovic R, Potenza B, Rinewalt A, Schultz J, Smith H, Dylewski M, Wibbenmeyer L, Bessey PQ, Carter J, Gamelli R, Goodwin C, Graves T, Hollowed K, Holmes J, Noordenbas J, Nordlund M, Savetamal A, Simpson P, Traber D, Traber L, Nedelec B, Donelan M, Baryza MJ, Bhavsar D, Blome-Eberwein S, Carrougher GJ, Hickerson W, Joe V, Jordan M, Kowalske K, Murray D, Murray VK, Parry I, Peck M, Reilly D, Schneider JC, Ware L, Singer AJ, Boyce ST, Ahrenholz DH, Chang P, Clark RA, Fey R, Fidler P, Garner W, Greenhalgh D, Honari S, Jones L, Kagan R, Kirby J, Leggett J, Meyer N, Reigart C, Richey K, Rosenberg L, Weber J, Wiggins B. Summary of the 2012 ABA Burn Quality Consensus conference. J Burn Care Res. 2013 Jul-Aug; 34(4):361-85.
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Jourdan M, Deutz NE, Cynober L, Aussel C. Consequences of age-related splanchnic sequestration of leucine on interorgan glutamine metabolism in old rats. J Appl Physiol (1985). 2013 Jul 15; 115(2):229-34.
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Rubio I, Suva LJ, Todorova V, Bhattacharyya S, Kaufmann Y, Maners A, Smith M, Klimberg VS. Oral glutamine reduces radiation morbidity in breast conservation surgery. JPEN J Parenter Enteral Nutr. 2013 Sep; 37(5):623-30.
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Simpson NE, Tryndyak VP, Pogribna M, Beland FA, Pogribny IP. Modifying metabolically sensitive histone marks by inhibiting glutamine metabolism affects gene expression and alters cancer cell phenotype. Epigenetics. 2012 Dec 01; 7(12):1413-20.
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