 Crohn Disease
"Crohn Disease" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.
| Descriptor ID |
D003424
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| MeSH Number(s) |
C06.405.205.731.500 C06.405.469.432.500
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| Concept/Terms |
Crohn Disease- Crohn Disease
- Inflammatory Bowel Disease 1
- Regional Enteritis
- Crohn's Disease
- Crohns Disease
Ileitis, Terminal- Ileitis, Terminal
- Terminal Ileitis
- Ileitis, Regional
- Regional Ileitides
- Regional Ileitis
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Below are MeSH descriptors whose meaning is more general than "Crohn Disease".
Below are MeSH descriptors whose meaning is more specific than "Crohn Disease".
This graph shows the total number of publications written about "Crohn Disease" by people in UAMS Profiles by year, and whether "Crohn Disease" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2022 | 5 | 0 | 5 | | 2021 | 6 | 1 | 7 | | 2020 | 4 | 2 | 6 | | 2019 | 5 | 0 | 5 | | 2018 | 2 | 1 | 3 | | 2017 | 5 | 0 | 5 | | 2016 | 5 | 1 | 6 | | 2015 | 4 | 2 | 6 | | 2013 | 3 | 0 | 3 | | 2012 | 2 | 1 | 3 | | 2011 | 1 | 0 | 1 | | 2010 | 2 | 0 | 2 | | 2007 | 1 | 0 | 1 | | 2003 | 2 | 1 | 3 | | 2000 | 0 | 1 | 1 | | 1995 | 1 | 0 | 1 | | 1991 | 1 | 0 | 1 | | 1990 | 1 | 0 | 1 | | 1989 | 0 | 1 | 1 | | 1988 | 1 | 0 | 1 |
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Below are the most recent publications written about "Crohn Disease" by people in Profiles over the past ten years.
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Rønnow Sand J, Troelsen FS, Horváth-Puhó E, Henderson VW, Sørensen HT, Erichsen R. Risk of dementia in patients with inflammatory bowel disease: a Danish population-based study. Aliment Pharmacol Ther. 2022 09; 56(5):831-843.
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Azab B, Rabab'h O, Aburizeg D, Mohammad H, Dardas Z, Mustafa L, Khasawneh RA, Awad H, Hatmal MM, Altamimi E. Potential Composite Digenic Contribution of NPC1 and NOD2 Leading to Atypical Lethal Niemann-Pick Type C with Initial Crohn's Disease-like Presentation: Genotype-Phenotype Correlation Study. Genes (Basel). 2022 05 29; 13(6).
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Moore MM, Gee MS, Iyer RS, Chan SS, Ayers TD, Bardo DME, Chandra T, Cooper ML, Dotson JL, Gadepalli SK, Gill AE, Levin TL, Nadel HR, Schooler GR, Shet NS, Squires JH, Trout AT, Wall JJ, Rigsby CK. ACR Appropriateness Criteria® Crohn Disease-Child. J Am Coll Radiol. 2022 05; 19(5S):S19-S36.
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Takakura WR, Mirocha J, Ovsepyan G, Zaghiyan KN, Syal G, Fleshner P. Magnitude of Preoperative C-Reactive Protein Elevation Is Associated With De Novo Crohn's Disease After Ileal Pouch-Anal Anastomosis in Patients With Severe Colitis. Dis Colon Rectum. 2022 03 01; 65(3):399-405.
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Syal G, Sparrow MP, Velayos F, Cheifetz AS, Devlin S, Irving PM, Kaplan GG, Raffals LE, Ullman T, Gecse KB, Fleshner PR, Lightner AL, Siegel CA, Melmed GY. Appropriateness of Medical and Surgical Treatments for Chronic Pouchitis Using RAND/UCLA Appropriateness Methodology. Dig Dis Sci. 2022 10; 67(10):4687-4694.
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Avalos DJ, Satiya J, Contreras A, Trivedi S, Alvarado L, Dodoo C, Dwivedi AK, Zuckerman MJ. Latin Americans and US Hispanics show differences in IBD phenotype: a systematic review with meta-analysis. J Investig Med. 2022 04; 70(4):919-933.
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Parrish AB, Lopez NE, Truong A, Zaghiyan K, Melmed GY, McGovern DPB, Ha C, Syal G, Bonthala N, Jain A, Landers CJ, Targan SR, Fleshner P. Preoperative Serum Vedolizumab Levels Do Not Impact Postoperative Outcomes in Inflammatory Bowel Disease. Dis Colon Rectum. 2021 10 01; 64(10):1259-1266.
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Syal G, Fleshner PR, Melmed GY. Endoscopic evaluation after surgery in inflammatory bowel disease. Lancet Gastroenterol Hepatol. 2021 09; 6(9):690-691.
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Truong A, Zaghiyan KN, Mirocha J, Melmed GY, McGovern DPB, Syal G, Ha CY, Targan SR, Fleshner PR. Antitumour necrosis factor therapy is associated with de novo Crohn's disease after ileal pouch-anal anastomosis. Colorectal Dis. 2021 Sep; 23(9):2416-2424.
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Syal G, Shemtov R, Bonthala N, Vasiliauskas EA, Feldman EJ, Zaghiyan K, Ha CY, McGovern DPB, Targan SR, Melmed GY, Fleshner PR. Pre-pouch Ileitis is Associated with Development of Crohn's Disease-like Complications and Pouch Failure. J Crohns Colitis. 2021 Jun 22; 15(6):960-968.
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Osterman MT, VanDussen KL, Gordon IO, Davis EM, Li K, Simpson K, Ciorba M, Glover SC, Abraham B, Guo X, Yee EU, Allard FD, Perrigoue JG, Claggett B, Shen B, Stappenbeck TS, Liu JJ. Epithelial Cell Biomarkers Are Predictive of Response to Biologic Agents in Crohn's Disease. Inflamm Bowel Dis. 2021 04 15; 27(5):677-685.
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Farias E Silva K, Nanini HF, Cascabulho CM, Rosas SLB, Santana PT, Carneiro AJV, Anaissie E, Nucci M, de Souza HSP. Serum 1,3-beta-D-glucan as a noninvasive test to predict histologic activity in patients with inflammatory bowel disease. World J Gastroenterol. 2021 Mar 07; 27(9):866-885.
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Price KN, Hendricks AJ, Goodrich ME, Krase JM, Shi VY. Widespread pustular eruption following probiotic use. Dermatol Online J. 2020 Nov 15; 26(11).
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Kilgore DA, Behrens AW, Siddiqui MZ, Chancellor JR, Phillips PH, Uwaydat SH, Vonlanthen MG, Gonzalez-Krellwitz L, Sallam AB. Inflammatory choroiditis and papillitis from Crohn's disease in a child. J AAPOS. 2021 02; 25(1):37-40.
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Fenster M, Alayo QA, Khatiwada A, Wang W, Dimopoulos C, Gutierrez A, Ciorba MA, Christophi GP, Hirten RP, Ha C, Beniwal-Patel P, Cohen BL, Syal G, Yarur A, Patel A, Colombel JF, Pekow J, Ungaro RC, Rubin DT, Deepak P. Real-World Effectiveness and Safety of Tofacitinib in Crohn's Disease and IBD-U: A Multicenter Study From the TROPIC Consortium. Clin Gastroenterol Hepatol. 2021 10; 19(10):2207-2209.e3.
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Annapureddy N, Nalleballe K, Onteddu SR, Sharma R, Sheng S, Kovvuru S, Siddamreddy S, Mandhadi R. Biologics in systemic autoimmune diseases during COVID-19 pandemic. Clin Rheumatol. 2020 12; 39(12):3529-3531.
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Osterman MT, Gordon IO, Davis EM, Ciorba M, Glover SC, Abraham B, Khan F, Guo X, Yee EU, Allard FD, Claggett B, Shen B, Liu JJ. Mucosal Biomarker of Innate Immune Activation Predicts Response to Vedolizumab in Crohn's Disease. Inflamm Bowel Dis. 2020 09 18; 26(10):1554-1561.
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Ashktorab H, Brim H, Hassan S, Nouraie M, Gebreselassie A, Laiyemo AO, Kibreab A, Aduli F, Latella G, Brant SR, Sherif Z, Habtezion A. Inflammatory polyps occur more frequently in inflammatory bowel disease than other colitis patients. BMC Gastroenterol. 2020 Jun 05; 20(1):170.
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Bottoms L, Leighton D, Carpenter R, Anderson S, Langmead L, Ramage J, Faulkner J, Coleman E, Fairhurst C, Seed M, Tew G. Affective and enjoyment responses to 12 weeks of high intensity interval training and moderate continuous training in adults with Crohn's disease. PLoS One. 2019; 14(9):e0222060.
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Berman HS, Villa NM, Shi VY, Hsiao JL. Guselkumab in the treatment of concomitant hidradenitis suppurativa, psoriasis, and Crohn's disease. J Dermatolog Treat. 2021 Mar; 32(2):261-263.
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Gregory M, Weaver KN, Hoversten P, Hicks SB, Patel D, Ciorba MA, Gutierrez AM, Beniwal-Patel P, Palam S, Syal G, Herfarth HH, Christophi G, Raffals L, Barnes EL, Deepak P. Efficacy of Vedolizumab for Refractory Pouchitis of the Ileo-anal Pouch: Results From a Multicenter US Cohort. Inflamm Bowel Dis. 2019 08 20; 25(9):1569-1576.
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Weaver KN, Gregory M, Syal G, Hoversten P, Hicks SB, Patel D, Christophi G, Beniwal-Patel P, Isaacs KL, Raffals L, Deepak P, Herfarth HH, Barnes EL. Ustekinumab Is Effective for the Treatment of Crohn's Disease of the Pouch in a Multicenter Cohort. Inflamm Bowel Dis. 2019 03 14; 25(4):767-774.
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Tew GA, Leighton D, Carpenter R, Anderson S, Langmead L, Ramage J, Faulkner J, Coleman E, Fairhurst C, Seed M, Bottoms L. High-intensity interval training and moderate-intensity continuous training in adults with Crohn's disease: a pilot randomised controlled trial. BMC Gastroenterol. 2019 Jan 29; 19(1):19.
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Quera R, Moreno M, Simian D, Ibáñez P, Lubascher J, Figueroa C, Flores L, Kronberg U, Pizarro G, Fluxá D. [Usefulness of therapeutic monitoring of infliximab in the treatment of inflammatory bowel disease]. Rev Med Chil. 2018 Nov; 146(11):1241-1251.
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Nabaweesi R, Ramakrishnaiah RH, Aitken ME, Rettiganti MR, Luo C, Maxson RT, Glasier CM, Kenney PJ, Robbins JM. Authors' Reply. J Am Coll Radiol. 2018 06; 15(6):825-826.
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Simoes CC, Ghouri YA, Merwat SN, Stevenson HL. Budd-Chiari syndrome: a rare and life-threatening complication of Crohn's disease. BMJ Case Rep. 2018 Jan 17; 2018.
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Evans MS, Googe PB, Morrell DS. Persistent Perianal Rash in a Young Boy. Clin Pediatr (Phila). 2018 09; 57(10):1243-1245.
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Feldbrügge L, Moss AC, Yee EU, Csizmadia E, Mitsuhashi S, Longhi MS, Sandhu B, Stephan H, Wu Y, Cheifetz AS, Müller CE, Sévigny J, Robson SC, Jiang ZG. Expression of Ecto-nucleoside Triphosphate Diphosphohydrolases-2 and -3 in the Enteric Nervous System Affects Inflammation in Experimental Colitis and Crohn's Disease. J Crohns Colitis. 2017 Sep 01; 11(9):1113-1123.
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Dharmaraj R, Nugent M, Simpson P, Arca M, Gurram B, Werlin S. Outcomes after fecal diversion for colonic and perianal Crohn disease in children. J Pediatr Surg. 2018 Mar; 53(3):472-476.
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Samson CM, Mager D, Frazee S, Yu F. Remission in Pediatric Inflammatory Bowel Disease Correlates With Prescription Refill Adherence Rates. J Pediatr Gastroenterol Nutr. 2017 04; 64(4):575-579.
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Triantafyllou K, Gkolfakis P, Viazis N, Tsibouris P, Tsigaridas A, Apostolopoulos P, Anastasiou J, Hounda E, Skianis I, Katopodi K, Ndini X, Alexandrakis G, Karamanolis DG. A 13-year time trend analysis of 3724 small bowel video capsule endoscopies and a forecast model during the financial crisis in Greece. Eur J Gastroenterol Hepatol. 2017 Feb; 29(2):185-191.
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Dharmaraj R, Dasgupta M, Simpson P, Noe J. Predictors of Pouchitis After Ileal Pouch-Anal Anastomosis in Children. J Pediatr Gastroenterol Nutr. 2016 12; 63(6):e210-e211.
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Sarver D, Guidry C, Ram R, Pandey T, Jambhekar K. Magnetic Resonance Enterography (MRE): The role of imaging in the management of adult patients with Crohn's disease. J Ark Med Soc. 2016 Dec; 113(6):136-139.
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Ward DI, McDonough EM. Unusual Ulcerations in Crohn Disease. J Pediatr Gastroenterol Nutr. 2016 11; 63(5):e118.
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Heath RD, Tahan V. Allogenic adipose derived stem cells present a potential novel approach for treating refractory fistulizing Crohn's disease. Turk J Gastroenterol. 2016 11; 27(6):568-569.
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Simian D, Fluxá D, Flores L, Lubascher J, Ibáñez P, Figueroa C, Kronberg U, Acuña R, Moreno M, Quera R. Inflammatory bowel disease: A descriptive study of 716 local Chilean patients. World J Gastroenterol. 2016 Jun 14; 22(22):5267-75.
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Shakhnovich V, Vyhlidal C, Friesen C, Hildreth A, Singh V, Daniel J, Kearns GL, Leeder JS. Decreased Pregnane X Receptor Expression in Children with Active Crohn's Disease. Drug Metab Dispos. 2016 07; 44(7):1066-9.
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Sahi KS, Lee KS, Moss A, Yee E, Allard F, Brook A, Mortele KJ. MR Enterography of the Ileoanal Pouch: Descriptive Radiologic Analysis With Endoscopic and Pathologic Correlation. AJR Am J Roentgenol. 2015 Nov; 205(5):W478-84.
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Miklavcic JJ, Hart TD, Lees GM, Shoemaker GK, Schnabl KL, Larsen BM, Bathe OF, Thomson AB, Mazurak VC, Clandinin MT. Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease. World J Gastroenterol. 2015 Sep 21; 21(35):10080-90.
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Viazis N, Koukouratos T, Anastasiou J, Giakoumis M, Triantos C, Tsolias C, Theocharis G, Karamanolis DG. Azathioprine discontinuation earlier than 6 months in Crohn's disease patients started on anti-TNF therapy is associated with loss of response and the need for anti-TNF dose escalation. Eur J Gastroenterol Hepatol. 2015 Apr; 27(4):436-41.
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Adamski J, Kinard T, Ipe T, Cooling L. Extracorporeal photopheresis for the treatment of autoimmune diseases. Transfus Apher Sci. 2015 Apr; 52(2):171-82.
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Gondim Fde A, Oliveira GR, Teles BC, Souza MH, Braga LL, Messias EL. A case-control study of the prevalence of neurological diseases in inflammatory bowel disease (IBD). Arq Neuropsiquiatr. 2015 Feb; 73(2):119-24.
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Inamdar S, Volfson A, Rosen L, Sunday S, Katz S, Sultan K. Smoking and early infliximab response in Crohn’s disease: a meta-analysis. J Crohns Colitis. 2015 Feb; 9(2):140-6.
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Sultan K, Inamdar S, Hirten R. The Uncertain Role of Immunomodulator Maintenance After Cessation of Anti-Tumor Necrosis Factor a Therapy. Clin Gastroenterol Hepatol. 2015 Aug; 13(8):1551-2.
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Ambruzs JM, Walker PD, Larsen CP. The histopathologic spectrum of kidney biopsies in patients with inflammatory bowel disease. Clin J Am Soc Nephrol. 2014 Feb; 9(2):265-70.
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Adamiak T, Walkiewicz-Jedrzejczak D, Fish D, Brown C, Tung J, Khan K, Faubion W, Park R, Heikenen J, Yaffee M, Rivera-Bennett MT, Wiedkamp M, Stephens M, Noel R, Nugent M, Nebel J, Simpson P, Kappelman MD, Kugathasan S. Incidence, clinical characteristics, and natural history of pediatric IBD in Wisconsin: a population-based epidemiological study. Inflamm Bowel Dis. 2013 May; 19(6):1218-23.
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Leu SB, Shulman SC, Steelman CK, Lamps LW, Bulut OP, Abramowsky CR, Gold BD, Szlam S, Stockwell C, Havens J, Kolta S, Shehata BM. Pathogenic Yersinia DNA in intestinal specimens of pediatric patients with Crohn's disease. Fetal Pediatr Pathol. 2013 Oct; 32(5):367-70.
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