 Crohn Disease
"Crohn Disease" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.
| Descriptor ID |
D003424
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| MeSH Number(s) |
C06.405.205.731.500 C06.405.469.432.500
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| Concept/Terms |
Crohn Disease- Crohn Disease
- Inflammatory Bowel Disease 1
- Regional Enteritis
- Crohn's Disease
- Crohns Disease
Ileitis, Terminal- Ileitis, Terminal
- Terminal Ileitis
- Ileitis, Regional
- Regional Ileitides
- Regional Ileitis
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Below are MeSH descriptors whose meaning is more general than "Crohn Disease".
Below are MeSH descriptors whose meaning is more specific than "Crohn Disease".
This graph shows the total number of publications written about "Crohn Disease" by people in UAMS Profiles by year, and whether "Crohn Disease" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2025 | 1 | 0 | 1 | | 2024 | 7 | 1 | 8 | | 2023 | 4 | 0 | 4 | | 2022 | 10 | 0 | 10 | | 2021 | 5 | 1 | 6 | | 2020 | 4 | 1 | 5 | | 2019 | 4 | 0 | 4 | | 2018 | 2 | 1 | 3 | | 2017 | 4 | 0 | 4 | | 2016 | 5 | 1 | 6 | | 2015 | 3 | 1 | 4 | | 2013 | 2 | 0 | 2 | | 2012 | 1 | 1 | 2 | | 2011 | 1 | 0 | 1 | | 2010 | 1 | 0 | 1 | | 2007 | 1 | 0 | 1 | | 2003 | 2 | 1 | 3 | | 2000 | 0 | 1 | 1 | | 1991 | 1 | 0 | 1 | | 1990 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Crohn Disease" by people in Profiles over the past ten years.
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Zeky N, LeBlanc C, Yang S, McDonough E, Dhaliwal J, Moulton D. Food access and the severity of newly diagnosed pediatric inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2025 Apr; 80(4):664-672.
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Khan HH, Munden MM, Spence LH, Jones RH, Whatley J, Suppa C. Intestinal ultrasound at diagnosis of pediatric inflammatory bowel disease compared to endoscopy. J Pediatr Gastroenterol Nutr. 2025 Mar; 80(3):440-445.
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Brady RE, Salwen-Deremer JK, Tunnell NC, Winter MW. Understanding Medication Nonadherence in Crohn's Disease Patients: A Qualitative Evaluation. Inflamm Bowel Dis. 2024 11 04; 30(11):2046-2056.
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Adler J, Galanko JA, Ammoury R, Benkov KJ, Bousvaros A, Boyle B, Cabrera JM, Chun KY, Dorsey J, Ebach DR, Firestine AM, Gulati AS, Herfarth HH, Jester TW, Kaplan JL, Leibowitz I, Linville TM, Margolis PA, Minar P, Molle-Rios Z, Moses J, Olano K, Pashankar DS, Pitch L, Saeed SA, Samson CM, Sandberg K, Steiner SJ, Strople JA, Sullivan JS, Wali PD, Kappelman MD. HLA DQA1*05 and Risk of Antitumor Necrosis Factor Treatment Failure and Anti-Drug Antibody Development in Children With Crohn's Disease. Am J Gastroenterol. 2025 May 01; 120(5):1076-1086.
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Syal G, Barnes E, Raffals L, Al Kazzi E, Haydek J, Agrawal M, Singh S. Medical Therapies for Prevention and Treatment of Inflammatory Pouch Disorders-A Systematic Review and Meta-Analysis. Am J Gastroenterol. 2025 Jan 01; 120(1):135-150.
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Khrom M, Long M, Dube S, Robbins L, Botwin GJ, Yang S, Mengesha E, Li D, Naito T, Bonthala NN, Ha C, Melmed G, Rabizadeh S, Syal G, Vasiliauskas E, Ziring D, Brant SR, Cho J, Duerr RH, Rioux J, Schumm P, Silverberg M, Ananthakrishnan AN, Faubion WA, Jabri B, Lira SA, Newberry RD, Sandler RS, Xavier RJ, Kugathasan S, Hercules D, Targan SR, Sartor RB, Haritunians T, McGovern DPB. Comprehensive Association Analyses of Extraintestinal Manifestations in Inflammatory Bowel Disease. Gastroenterology. 2024 Jul; 167(2):315-332.
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Ebach DR, Jester TW, Galanko JA, Firestine AM, Ammoury R, Cabrera J, Bass J, Minar P, Olano K, Margolis P, Sandberg K, Linnville TM, Kaplan J, Pitch L, Steiner SJ, Bass D, Moses J, Adler J, Gulati AS, Wali P, Pashankar D, Ivanova A, Herfarth H, Wohl DA, Benkov KJ, Strople J, Sullivan J, Tung J, Molle-Rios Z, Saeed SA, Bousvaros A, Kappelman MD. High Body Mass Index and Response to Anti-Tumor Necrosis Factor Therapy in Pediatric Crohn's Disease. Am J Gastroenterol. 2024 06 01; 119(6):1110-1116.
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Ahuja D, Luo J, Qi Y, Syal G, Boland BS, Chang J, Ma C, Jairath V, Xu R, Singh S. Impact of Treatment Response on Risk of Serious Infections in Patients With Crohn's Disease: Secondary Analysis of the PYRAMID Registry. Clin Gastroenterol Hepatol. 2024 Jun; 22(6):1286-1294.e4.
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Barnes EL, Agrawal M, Syal G, Ananthakrishnan AN, Cohen BL, Haydek JP, Al Kazzi ES, Eisenstein S, Hashash JG, Sultan SS, Raffals LE, Singh S. AGA Clinical Practice Guideline on the Management of Pouchitis and Inflammatory Pouch Disorders. Gastroenterology. 2024 01; 166(1):59-85.
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Gu P, Dube S, Lee Y, Yang S, Li D, Haritunians T, Vasiliauskas E, Bonthala N, Syal G, Yarur A, Ziring D, Targan S, Rabizadeh S, Melmed GY, Fleshner P, McGovern DPB. Comparative Persistence of Non-tumor Necrosis Factor (TNF) vs. TNF Antagonists for Post-operative Prophylaxis in Crohn's Disease (CD). Dig Dis Sci. 2024 Jan; 69(1):235-245.
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Katibian DJ, Solitano V, Polk DB, Nguyen T, Ma C, Syal G, Kobayashi T, Hibi T, Buhl S, Ainsworth MA, Jairath V, Singh S. Withdrawal of Immunomodulators or TNF Antagonists in Patients With Inflammatory Bowel Diseases in Remission on Combination Therapy: A Systematic Review and Meta-analysis. Clin Gastroenterol Hepatol. 2024 01; 22(1):22-33.e6.
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Evaristo G, Szczepanski J, Farag MS, Rubin DT, Campbell LK, Marcus VA, Lamps LW, Hart J. Crohn's Disease Features in Anastomotic Biopsies from Patients With and Without Crohn's Disease: Diagnostic and Prognostic Value. Mod Pathol. 2023 Nov; 36(11):100325.
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Akhlaghpour M, Haritunians T, More SK, Thomas LS, Stamps DT, Dube S, Li D, Yang S, Landers CJ, Mengesha E, Hamade H, Murali R, Potdar AA, Wolf AJ, Botwin GJ, Khrom M, Ananthakrishnan AN, Faubion WA, Jabri B, Lira SA, Newberry RD, Sandler RS, Sartor RB, Xavier RJ, Brant SR, Cho JH, Duerr RH, Lazarev MG, Rioux JD, Schumm LP, Silverberg MS, Zaghiyan K, Fleshner P, Melmed GY, Vasiliauskas EA, Ha C, Rabizadeh S, Syal G, Bonthala NN, Ziring DA, Targan SR, Long MD, McGovern DPB, Michelsen KS. Genetic coding variant in complement factor B (CFB) is associated with increased risk for perianal Crohn's disease and leads to impaired CFB cleavage and phagocytosis. Gut. 2023 11; 72(11):2068-2080.
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Syal G, Melmed GY, Almario CV, Spiegel BMR. Azathioprine Withdrawal Is Cost-Effective in Patients with Crohn's Disease in Remission on Infliximab and Azathioprine. Dig Dis Sci. 2023 02; 68(2):404-413.
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Singh S, Kim J, Luo J, Paul P, Rudrapatna V, Park S, Zheng K, Syal G, Ha C, Fleshner P, McGovern D, Sauk JS, Limketkai B, Dulai PS, Boland BS, Eisenstein S, Ramamoorthy S, Melmed G, Mahadevan U, Sandborn WJ, Ohno-Machado L. Comparative Safety and Effectiveness of Biologic Therapy for Crohn's Disease: A CA-IBD Cohort Study. Clin Gastroenterol Hepatol. 2023 08; 21(9):2359-2369.e5.
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R?nnow Sand J, Troelsen FS, Horv?th-Puh? E, Henderson VW, S?rensen HT, Erichsen R. Risk of dementia in patients with inflammatory bowel disease: a Danish population-based study. Aliment Pharmacol Ther. 2022 09; 56(5):831-843.
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Almario CV, van Deen WK, Chen M, Gale R, Sidorkiewicz S, Choi SY, Bonthala N, Ha C, Syal G, Dupuy T, Liu X, Melmed GY, Spiegel BMR. Interactive Inflammatory Bowel Disease Biologics Decision Aid Does Not Improve Patient Outcomes Over Static Education: Results From a Randomized Trial. Am J Gastroenterol. 2022 09 01; 117(9):1508-1518.
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Gu P, Luo J, Kim J, Paul P, Limketkai B, Sauk JS, Park S, Parekh N, Zheng K, Rudrapatna V, Syal G, Ha C, McGovern DP, Melmed GY, Fleshner P, Eisenstein S, Ramamoorthy S, Dulai PS, Boland BS, Grunvald E, Mahadevan U, Ohno-Machado L, Sandborn WJ, Singh S. Effect of Obesity on Risk of Hospitalization, Surgery, and Serious Infection in Biologic-Treated Patients With Inflammatory Bowel Diseases: A CA-IBD Cohort Study. Am J Gastroenterol. 2022 10 01; 117(10):1639-1647.
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Azab B, Rabab'h O, Aburizeg D, Mohammad H, Dardas Z, Mustafa L, Khasawneh RA, Awad H, Hatmal MM, Altamimi E. Potential Composite Digenic Contribution of NPC1 and NOD2 Leading to Atypical Lethal Niemann-Pick Type C with Initial Crohn's Disease-like Presentation: Genotype-Phenotype Correlation Study. Genes (Basel). 2022 05 29; 13(6).
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Moore MM, Gee MS, Iyer RS, Chan SS, Ayers TD, Bardo DME, Chandra T, Cooper ML, Dotson JL, Gadepalli SK, Gill AE, Levin TL, Nadel HR, Schooler GR, Shet NS, Squires JH, Trout AT, Wall JJ, Rigsby CK. ACR Appropriateness Criteria? Crohn Disease-Child. J Am Coll Radiol. 2022 05; 19(5S):S19-S36.
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Freund MR, Perets M, Horesh N, Yellinek S, Halfteck G, Reissman P, Rosenthal RJ, Wexner SD. Prevalence, diagnosis, and surgical management of complex ileocolic-duodenal fistulas in Crohn's disease. Tech Coloproctol. 2022 08; 26(8):637-643.
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Takakura WR, Mirocha J, Ovsepyan G, Zaghiyan KN, Syal G, Fleshner P. Magnitude of Preoperative C-Reactive Protein Elevation Is Associated With De Novo Crohn's Disease After Ileal Pouch-Anal Anastomosis in Patients With Severe Colitis. Dis Colon Rectum. 2022 03 01; 65(3):399-405.
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Syal G, Sparrow MP, Velayos F, Cheifetz AS, Devlin S, Irving PM, Kaplan GG, Raffals LE, Ullman T, Gecse KB, Fleshner PR, Lightner AL, Siegel CA, Melmed GY. Appropriateness of Medical and Surgical Treatments for Chronic Pouchitis Using RAND/UCLA Appropriateness Methodology. Dig Dis Sci. 2022 10; 67(10):4687-4694.
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Avalos DJ, Satiya J, Contreras A, Trivedi S, Alvarado L, Dodoo C, Dwivedi AK, Zuckerman MJ. Latin Americans and US Hispanics show differences in IBD phenotype: a systematic review with meta-analysis. J Investig Med. 2022 04; 70(4):919-933.
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Parrish AB, Lopez NE, Truong A, Zaghiyan K, Melmed GY, McGovern DPB, Ha C, Syal G, Bonthala N, Jain A, Landers CJ, Targan SR, Fleshner P. Preoperative Serum Vedolizumab Levels Do Not Impact Postoperative Outcomes in Inflammatory Bowel Disease. Dis Colon Rectum. 2021 10 01; 64(10):1259-1266.
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Syal G, Fleshner PR, Melmed GY. Endoscopic evaluation after surgery in inflammatory bowel disease. Lancet Gastroenterol Hepatol. 2021 09; 6(9):690-691.
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Truong A, Zaghiyan KN, Mirocha J, Melmed GY, McGovern DPB, Syal G, Ha CY, Targan SR, Fleshner PR. Antitumour necrosis factor therapy is associated with de novo Crohn's disease after ileal pouch-anal anastomosis. Colorectal Dis. 2021 Sep; 23(9):2416-2424.
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Syal G, Shemtov R, Bonthala N, Vasiliauskas EA, Feldman EJ, Zaghiyan K, Ha CY, McGovern DPB, Targan SR, Melmed GY, Fleshner PR. Pre-pouch Ileitis is Associated with Development of Crohn's Disease-like Complications and Pouch Failure. J Crohns Colitis. 2021 Jun 22; 15(6):960-968.
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Osterman MT, VanDussen KL, Gordon IO, Davis EM, Li K, Simpson K, Ciorba M, Glover SC, Abraham B, Guo X, Yee EU, Allard FD, Perrigoue JG, Claggett B, Shen B, Stappenbeck TS, Liu JJ. Epithelial Cell Biomarkers Are Predictive of Response to Biologic Agents in Crohn's Disease. Inflamm Bowel Dis. 2021 04 15; 27(5):677-685.
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Farias E Silva K, Nanini HF, Cascabulho CM, Rosas SLB, Santana PT, Carneiro AJV, Anaissie E, Nucci M, de Souza HSP. Serum 1,3-beta-D-glucan as a noninvasive test to predict histologic activity in patients with inflammatory bowel disease. World J Gastroenterol. 2021 Mar 07; 27(9):866-885.
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Price KN, Hendricks AJ, Goodrich ME, Krase JM, Shi VY. Widespread pustular eruption following probiotic use. Dermatol Online J. 2020 Nov 15; 26(11).
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Kilgore DA, Behrens AW, Siddiqui MZ, Chancellor JR, Phillips PH, Uwaydat SH, Vonlanthen MG, Gonzalez-Krellwitz L, Sallam AB. Inflammatory choroiditis and papillitis from Crohn's disease in a child. J AAPOS. 2021 02; 25(1):37-40.
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Fenster M, Alayo QA, Khatiwada A, Wang W, Dimopoulos C, Gutierrez A, Ciorba MA, Christophi GP, Hirten RP, Ha C, Beniwal-Patel P, Cohen BL, Syal G, Yarur A, Patel A, Colombel JF, Pekow J, Ungaro RC, Rubin DT, Deepak P. Real-World Effectiveness and Safety of Tofacitinib in Crohn's Disease and IBD-U: A Multicenter Study From the TROPIC Consortium. Clin Gastroenterol Hepatol. 2021 10; 19(10):2207-2209.e3.
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Annapureddy N, Nalleballe K, Onteddu SR, Sharma R, Sheng S, Kovvuru S, Siddamreddy S, Mandhadi R. Biologics in systemic autoimmune diseases during COVID-19 pandemic. Clin Rheumatol. 2020 12; 39(12):3529-3531.
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Osterman MT, Gordon IO, Davis EM, Ciorba M, Glover SC, Abraham B, Khan F, Guo X, Yee EU, Allard FD, Claggett B, Shen B, Liu JJ. Mucosal Biomarker of Innate Immune Activation Predicts Response to Vedolizumab in Crohn's Disease. Inflamm Bowel Dis. 2020 09 18; 26(10):1554-1561.
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Ashktorab H, Brim H, Hassan S, Nouraie M, Gebreselassie A, Laiyemo AO, Kibreab A, Aduli F, Latella G, Brant SR, Sherif Z, Habtezion A. Inflammatory polyps occur more frequently in inflammatory bowel disease than other colitis patients. BMC Gastroenterol. 2020 Jun 05; 20(1):170.
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Bottoms L, Leighton D, Carpenter R, Anderson S, Langmead L, Ramage J, Faulkner J, Coleman E, Fairhurst C, Seed M, Tew G. Affective and enjoyment responses to 12 weeks of high intensity interval training and moderate continuous training in adults with Crohn's disease. PLoS One. 2019; 14(9):e0222060.
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Berman HS, Villa NM, Shi VY, Hsiao JL. Guselkumab in the treatment of concomitant hidradenitis suppurativa, psoriasis, and Crohn's disease. J Dermatolog Treat. 2021 Mar; 32(2):261-263.
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Gregory M, Weaver KN, Hoversten P, Hicks SB, Patel D, Ciorba MA, Gutierrez AM, Beniwal-Patel P, Palam S, Syal G, Herfarth HH, Christophi G, Raffals L, Barnes EL, Deepak P. Efficacy of Vedolizumab for Refractory Pouchitis of the Ileo-anal Pouch: Results From a Multicenter US Cohort. Inflamm Bowel Dis. 2019 08 20; 25(9):1569-1576.
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Weaver KN, Gregory M, Syal G, Hoversten P, Hicks SB, Patel D, Christophi G, Beniwal-Patel P, Isaacs KL, Raffals L, Deepak P, Herfarth HH, Barnes EL. Ustekinumab Is Effective for the Treatment of Crohn's Disease of the Pouch in a Multicenter Cohort. Inflamm Bowel Dis. 2019 03 14; 25(4):767-774.
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Tew GA, Leighton D, Carpenter R, Anderson S, Langmead L, Ramage J, Faulkner J, Coleman E, Fairhurst C, Seed M, Bottoms L. High-intensity interval training and moderate-intensity continuous training in adults with Crohn's disease: a pilot randomised controlled trial. BMC Gastroenterol. 2019 Jan 29; 19(1):19.
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Quera R, Moreno M, Simian D, Ib??ez P, Lubascher J, Figueroa C, Flores L, Kronberg U, Pizarro G, Flux? D. [Usefulness of therapeutic monitoring of infliximab in the treatment of inflammatory bowel disease]. Rev Med Chil. 2018 Nov; 146(11):1241-1251.
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Nabaweesi R, Ramakrishnaiah RH, Aitken ME, Rettiganti MR, Luo C, Maxson RT, Glasier CM, Kenney PJ, Robbins JM. Authors' Reply. J Am Coll Radiol. 2018 06; 15(6):825-826.
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Simoes CC, Ghouri YA, Merwat SN, Stevenson HL. Budd-Chiari syndrome: a rare and life-threatening complication of Crohn's disease. BMJ Case Rep. 2018 Jan 17; 2018.
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Evans MS, Googe PB, Morrell DS. Persistent Perianal Rash in a Young Boy. Clin Pediatr (Phila). 2018 09; 57(10):1243-1245.
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Feldbr?gge L, Moss AC, Yee EU, Csizmadia E, Mitsuhashi S, Longhi MS, Sandhu B, Stephan H, Wu Y, Cheifetz AS, M?ller CE, S?vigny J, Robson SC, Jiang ZG. Expression of Ecto-nucleoside Triphosphate Diphosphohydrolases-2 and -3 in the Enteric Nervous System Affects Inflammation in Experimental Colitis and Crohn's Disease. J Crohns Colitis. 2017 Sep 01; 11(9):1113-1123.
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Dharmaraj R, Nugent M, Simpson P, Arca M, Gurram B, Werlin S. Outcomes after fecal diversion for colonic and perianal Crohn disease in children. J Pediatr Surg. 2018 Mar; 53(3):472-476.
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Samson CM, Mager D, Frazee S, Yu F. Remission in Pediatric Inflammatory Bowel Disease Correlates With Prescription Refill Adherence Rates. J Pediatr Gastroenterol Nutr. 2017 04; 64(4):575-579.
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Triantafyllou K, Gkolfakis P, Viazis N, Tsibouris P, Tsigaridas A, Apostolopoulos P, Anastasiou J, Hounda E, Skianis I, Katopodi K, Ndini X, Alexandrakis G, Karamanolis DG. A 13-year time trend analysis of 3724 small bowel video capsule endoscopies and a forecast model during the financial crisis in Greece. Eur J Gastroenterol Hepatol. 2017 Feb; 29(2):185-191.
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Dharmaraj R, Dasgupta M, Simpson P, Noe J. Predictors of Pouchitis After Ileal Pouch-Anal Anastomosis in Children. J Pediatr Gastroenterol Nutr. 2016 12; 63(6):e210-e211.
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Sarver D, Guidry C, Ram R, Pandey T, Jambhekar K. Magnetic Resonance Enterography (MRE): The role of imaging in the management of adult patients with Crohn's disease. J Ark Med Soc. 2016 Dec; 113(6):136-139.
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Heath RD, Tahan V. Allogenic adipose derived stem cells present a potential novel approach for treating refractory fistulizing Crohn's disease. Turk J Gastroenterol. 2016 11; 27(6):568-569.
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Ward DI, McDonough EM. Unusual Ulcerations in Crohn Disease. J Pediatr Gastroenterol Nutr. 2016 11; 63(5):e118.
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Simian D, Flux? D, Flores L, Lubascher J, Ib??ez P, Figueroa C, Kronberg U, Acu?a R, Moreno M, Quera R. Inflammatory bowel disease: A descriptive study of 716 local Chilean patients. World J Gastroenterol. 2016 Jun 14; 22(22):5267-75.
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Shakhnovich V, Vyhlidal C, Friesen C, Hildreth A, Singh V, Daniel J, Kearns GL, Leeder JS. Decreased Pregnane X Receptor Expression in Children with Active Crohn's Disease. Drug Metab Dispos. 2016 07; 44(7):1066-9.
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Sahi KS, Lee KS, Moss A, Yee E, Allard F, Brook A, Mortele KJ. MR Enterography of the Ileoanal Pouch: Descriptive Radiologic Analysis With Endoscopic and Pathologic Correlation. AJR Am J Roentgenol. 2015 Nov; 205(5):W478-84.
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