 Autistic Disorder
"Autistic Disorder" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A disorder beginning in childhood. It is marked by the presence of markedly abnormal or impaired development in social interaction and communication and a markedly restricted repertoire of activity and interest. Manifestations of the disorder vary greatly depending on the developmental level and chronological age of the individual. (DSM-IV)
| Descriptor ID |
D001321
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| MeSH Number(s) |
F03.550.325.125
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| Concept/Terms |
Autistic Disorder- Autistic Disorder
- Disorder, Autistic
- Disorders, Autistic
- Kanner's Syndrome
- Kanner Syndrome
- Kanners Syndrome
- Syndrome, Kanner's
- Autism, Infantile
- Infantile Autism
- Autism
- Autisms
- Autism, Early Infantile
- Early Infantile Autism
- Infantile Autism, Early
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Below are MeSH descriptors whose meaning is more general than "Autistic Disorder".
Below are MeSH descriptors whose meaning is more specific than "Autistic Disorder".
This graph shows the total number of publications written about "Autistic Disorder" by people in UAMS Profiles by year, and whether "Autistic Disorder" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2025 | 1 | 0 | 1 | | 2024 | 4 | 3 | 7 | | 2023 | 7 | 1 | 8 | | 2022 | 7 | 0 | 7 | | 2021 | 1 | 1 | 2 | | 2020 | 2 | 0 | 2 | | 2019 | 3 | 0 | 3 | | 2018 | 2 | 0 | 2 | | 2017 | 4 | 3 | 7 | | 2016 | 1 | 2 | 3 | | 2015 | 3 | 0 | 3 | | 2014 | 6 | 0 | 6 | | 2013 | 2 | 2 | 4 | | 2012 | 5 | 1 | 6 | | 2010 | 2 | 0 | 2 | | 2009 | 4 | 0 | 4 | | 2008 | 4 | 0 | 4 | | 2007 | 2 | 0 | 2 | | 2006 | 3 | 0 | 3 | | 2004 | 1 | 1 | 2 |
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Below are the most recent publications written about "Autistic Disorder" by people in Profiles over the past ten years.
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Hill Z, McCarty PJ, Boles RG, Frye RE. A Mitochondrial Supplement Improves Function and Mitochondrial Activity in Autism: A Double-Blind Placebo-Controlled Cross-Over Trial. Int J Mol Sci. 2025 Mar 10; 26(6).
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Elkhateeb N, Crookes R, Spiller M, Pavinato L, Palermo F, Brusco A, Parker M, Park SM, Mendes AC, Saraiva JM, Hammer TB, Nazaryan-Petersen L, Barakat TS, Wilke M, Bhoj E, Ahrens-Nicklas RC, Li D, Nomakuchi T, Brilstra EH, Hunt D, Johnson D, Mansour S, Oprych K, Mehta SG, Platzer K, Schnabel F, Kiep H, Faust H, Prinzing G, Wiltrout K, Radley JA, Serrano Russi AH, Atallah I, Campos-Xavier B, Amor DJ, Morgan AT, Fagerberg C, Andersen UA, Andersen CB, Bijlsma EK, Bird LM, Mullegama SV, Green A, Isidor B, Cogn? B, Kenny J, Lynch SA, Quin S, Low K, Herget T, Kort?m F, Levy RJ, Morrison JL, Wheeler PG, Narumanch T, Peron K, Matthews N, Uhlman J, Bell L, Pang L, Scurr I, Belles RS, Salbert BA, Schaefer GB, Green S, Ros A, Rodr?guez-Palmero A, Vi?njar T, Writzl K, Vasudevan PC, Balasubramanian M. Expanding the phenotype and genotype spectrum of TAOK1 neurodevelopmental disorder and delineating TAOK2 neurodevelopmental disorder. Genet Med. 2025 Mar; 27(3):101348.
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Collu R, Zarate YA, Xia W, Fish JL. Individuals with SATB2-associated syndrome have impaired vitamin and energy metabolism pathways. Metab Brain Dis. 2024 Nov 14; 40(1):3.
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Albert P, Kaldes G, Tully E, Romski M, Morris RD, Sevcik RA, Dilly L. Measuring autism with the ADOS-2 using a bifactor model. Autism Res. 2024 Dec; 17(12):2487-2502.
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Weiss MD, Daniolos PT, Coughlin K, Mulvaney-Day N, Cook B, Rosenblum D. A Scoping Review of the Intersectionality of Autism and Intellectual and Developmental Disability with Social Inequity on Diagnosis and Treatment of Youth. J Child Adolesc Psychopharmacol. 2024 09; 34(7):292-301.
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Onovbiona H, Quetsch L, Del Rosario EA. Exploring Factors of Diagnostic Timing Among Black Autistic Youth. J Autism Dev Disord. 2025 Apr; 55(4):1438-1449.
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Frye RE, Rose S, Voinsky I, Gurwitz D. Nitrosative Stress in Autism: Supportive Evidence and Implications for Mitochondrial Dysfunction. Adv Sci (Weinh). 2024 Apr; 11(16):e2304439.
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Bar O, Vahey E, Mintz M, Frye RE, Boles RG. Reanalysis of Trio Whole-Genome Sequencing Data Doubles the Yield in Autism Spectrum Disorder: De Novo Variants Present in Half. Int J Mol Sci. 2024 Jan 18; 25(2).
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Frye RE. Editorial: Mitochondrial Gene Variations Increase Autism Risk: Uncovering the Complex Polygenetic Landscape of Autism. J Am Acad Child Adolesc Psychiatry. 2024 Aug; 63(8):775-777.
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Onovbiona H, Quetsch L, Bradley R. Racial and Practical Barriers to Diagnostic and Treatment Services for Black Families of Autistic Youth: A Mixed-Method Exploration. J Autism Dev Disord. 2024 Dec; 54(12):4465-4480.
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Kilmer M, Hong M, Shah E. Relationship between caregiver adverse childhood events and age of autism spectrum diagnosis. J Pediatr Nurs. 2023 Nov-Dec; 73:e266-e272.
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Lu H, Zuo L, Roddick KM, Zhang P, Oku S, Garden J, Ge Y, Bellefontaine M, Delhaye M, Brown RE, Craig AM. Alternative splicing and heparan sulfation converge on neurexin-1 to control glutamatergic transmission and autism-related behaviors. Cell Rep. 2023 07 25; 42(7):112714.
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Frye RE. Succinic semialdehyde dehydrogenase deficiency: A model of neurocircuit imbalances in autism and potential insight into new biomarkers. Dev Med Child Neurol. 2023 12; 65(12):1544-1545.
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Muller K. Exploring the Clinical Feasibility of Alternative Word-Understanding Measures for Autistic Children With Minimal Spoken Language. Am J Speech Lang Pathol. 2023 05 04; 32(3):1322-1335.
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Quetsch LB, Brown C, Onovbiona H, Bradley R, Aloia L, Kanne S. Understanding aggression in autism across childhood: Comparisons with a non-autistic sample. Autism Res. 2023 06; 16(6):1185-1198.
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Senarathne UD, Indika NR, Jezela-Stanek A, Ciara E, Frye RE, Chen C, Stepien KM. Biochemical, Genetic and Clinical Diagnostic Approaches to Autism-Associated Inherited Metabolic Disorders. Genes (Basel). 2023 03 27; 14(4).
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Bircan E, Politis MD, Gokun Y, Luo C, Leonard H, Bourke J, Bower C, Nembhard WN. Intellectual disabilities and autism among children with congenital heart defects, Western Australia, 1983-2010. BMC Pediatr. 2023 03 04; 23(1):106.
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Barbaresi W, Cacia J, Friedman S, Fussell J, Hansen R, Hofer J, Roizen N, Stein REK, Vanderbilt D, Sideridis G. Clinician Diagnostic Certainty and the Role of the Autism Diagnostic Observation Schedule in Autism Spectrum Disorder Diagnosis in Young Children. JAMA Pediatr. 2022 12 01; 176(12):1233-1241.
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McMaughan DJD, Jones JL, Mulcahy A, Tucker EC, Beverly JG, Perez-Patron M. Hospitalizations Among Children and Youth With Autism in the United States: Frequency, Characteristics, and Costs. Intellect Dev Disabil. 2022 12 01; 60(6):484-503.
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Bolbocean C, Rhidenour KB, McCormack M, Suter B, Holder JL. Resilience, and positive parenting in parents of children with syndromic autism and intellectual disability. Evidence from the impact of the COVID-19 pandemic on family's quality of life and parent-child relationships. Autism Res. 2022 12; 15(12):2381-2398.
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Miceli F, Millevert C, Soldovieri MV, Mosca I, Ambrosino P, Carotenuto L, Schrader D, Lee HK, Riviello J, Hong W, Risen S, Emrick L, Amin H, Ville D, Edery P, de Bellescize J, Michaud V, Van-Gils J, Goizet C, Willemsen MH, Kleefstra T, M?ller RS, Bayat A, Devinsky O, Sands T, Korenke GC, Kluger G, Mefford HC, Brilstra E, Lesca G, Milh M, Cooper EC, Taglialatela M, Weckhuysen S. KCNQ2 R144 variants cause neurodevelopmental disability with language impairment and autistic features without neonatal seizures through a gain-of-function mechanism. EBioMedicine. 2022 Jul; 81:104130.
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Angkustsiri K, Fussell JJ, Bennett A, Schauer J, Ramirez-Celis A, Hansen RL, Van de Water J. Pilot Study of Maternal Autoantibody-Related Autism. J Dev Behav Pediatr. 2022 Oct-Nov 01; 43(8):465-471.
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Kilmer M, Boykin AA. Analysis of the 2000 to 2018 autism and developmental disabilities monitoring network surveillance reports: Implications for primary care clinicians. J Pediatr Nurs. 2022 Jul-Aug; 65:55-68.
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Allen K, Harrington J, Quetsch LB, Masse J, Cooke C, Paulson JF. Parent-Child Interaction Therapy for Children with Disruptive Behaviors and Autism: A Randomized Clinical Trial. J Autism Dev Disord. 2023 Jan; 53(1):390-404.
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Muller K, Brady NC, Fleming KK. Alternative receptive language assessment modalities and stimuli for autistic children who are minimally verbal. Autism. 2022 08; 26(6):1522-1535.
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Bolbocean C, And?jar FN, McCormack M, Suter B, Holder JL. Health-Related Quality of Life in Pediatric Patients with Syndromic Autism and their Caregivers. J Autism Dev Disord. 2022 Mar; 52(3):1334-1345.
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Kopel J, Grooms A, Ganapathy V, Clothier J. Metformin, valproic acid, and starvation induce seizures in a patient with partial SLC13A5 deficiency: a case of pharmaco-synergistic heterozygosity. Psychiatr Genet. 2021 02 01; 31(1):32-35.
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Zhu Y, Mordaunt CE, Durbin-Johnson BP, Caudill MA, Malysheva OV, Miller JW, Green R, James SJ, Melnyk SB, Fallin MD, Hertz-Picciotto I, Schmidt RJ, LaSalle JM. Expression Changes in Epigenetic Gene Pathways Associated With One-Carbon Nutritional Metabolites in Maternal Blood From Pregnancies Resulting in Autism and Non-Typical Neurodevelopment. Autism Res. 2021 01; 14(1):11-28.
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Chan E, Buzzard J, Helms R, Grigorian AP. Evaluation and Clinical Course of Keratomalacia With Descemetocele in a Child With Autism and Vitamin A Deficiency. J Pediatr Ophthalmol Strabismus. 2020 Jan 24; 57:e1-e3.
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Ross PJ, Zhang WB, Mok RSF, Zaslavsky K, Deneault E, D'Abate L, Rodrigues DC, Yuen RKC, Faheem M, Mufteev M, Piekna A, Wei W, Pasceri P, Landa RJ, Nagy A, Varga B, Salter MW, Scherer SW, Ellis J. Synaptic Dysfunction in Human Neurons With Autism-Associated Deletions in PTCHD1-AS. Biol Psychiatry. 2020 01 15; 87(2):139-149.
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Sands TT, Miceli F, Lesca G, Beck AE, Sadleir LG, Arrington DK, Sch?newolf-Greulich B, Moutton S, Lauritano A, Nappi P, Soldovieri MV, Scheffer IE, Mefford HC, Stong N, Heinzen EL, Goldstein DB, Perez AG, Kossoff EH, Stocco A, Sullivan JA, Shashi V, Gerard B, Francannet C, Bisgaard AM, T?mer Z, Willems M, Rivier F, Vitobello A, Thakkar K, Rajan DS, Barkovich AJ, Weckhuysen S, Cooper EC, Taglialatela M, Cilio MR. Autism and developmental disability caused by KCNQ3 gain-of-function variants. Ann Neurol. 2019 08; 86(2):181-192.
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Frye RE, Shimasaki C. Reliability of the Cunningham Panel. Transl Psychiatry. 2019 04 08; 9(1):129.
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Cogn? B, Ehresmann S, Beauregard-Lacroix E, Rousseau J, Besnard T, Garcia T, Petrovski S, Avni S, McWalter K, Blackburn PR, Sanders SJ, Uguen K, Harris J, Cohen JS, Blyth M, Lehman A, Berg J, Li MH, Kini U, Joss S, von der Lippe C, Gordon CT, Humberson JB, Robak L, Scott DA, Sutton VR, Skraban CM, Johnston JJ, Poduri A, Nordenskj?ld M, Shashi V, Gerkes EH, Bongers EMHF, Gilissen C, Zarate YA, Kvarnung M, Lally KP, Kulch PA, Daniels B, Hernandez-Garcia A, Stong N, McGaughran J, Retterer K, Tveten K, Sullivan J, Geisheker MR, Stray-Pedersen A, Tarpinian JM, Klee EW, Sapp JC, Zyskind J, Holla ?L, Bedoukian E, Filippini F, Guimier A, Picard A, Busk ?L, Punetha J, Pfundt R, Lindstrand A, Nordgren A, Kalb F, Desai M, Ebanks AH, Jhangiani SN, Dewan T, Coban Akdemir ZH, Telegrafi A, Zackai EH, Begtrup A, Song X, Toutain A, Wentzensen IM, Odent S, Bonneau D, Latypova X, Deb W, Redon S, Bilan F, Legendre M, Troyer C, Whitlock K, Caluseriu O, Murphree MI, Pichurin PN, Agre K, Gavrilova R, Rinne T, Park M, Shain C, Heinzen EL, Xiao R, Amiel J, Lyonnet S, Isidor B, Biesecker LG, Lowenstein D, Posey JE, Denomm?-Pichon AS, F?rec C, Yang XJ, Rosenfeld JA, Gilbert-Dussardier B, Audebert-Bellanger S, Redon R, Stessman HAF, Nellaker C, Yang Y, Lupski JR, Goldstein DB, Eichler EE, Bolduc F, B?zieau S, K?ry S, Campeau PM. Missense Variants in the Histone Acetyltransferase Complex Component Gene TRRAP Cause Autism and Syndromic Intellectual Disability. Am J Hum Genet. 2019 03 07; 104(3):530-541.
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Cogill SB, Srivastava AK, Yang MQ, Wang L. Co-expression of long non-coding RNAs and autism risk genes in the developing human brain. BMC Syst Biol. 2018 12 14; 12(Suppl 7):91.
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Brady NC, Fleming K, Romine RS, Holbrook A, Muller K, Kasari C. Concurrent Validity and Reliability for the Communication Complexity Scale. Am J Speech Lang Pathol. 2018 02 06; 27(1):237-246.
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Tanaka AJ, Cho MT, Willaert R, Retterer K, Zarate YA, Bosanko K, Stefans V, Oishi K, Williamson A, Wilson GN, Basinger A, Barbaro-Dieber T, Ortega L, Sorrentino S, Gabriel MK, Anderson IJ, Sacoto MJG, Schnur RE, Chung WK. De novo variants in EBF3 are associated with hypotonia, developmental delay, intellectual disability, and autism. Cold Spring Harb Mol Case Stud. 2017 Nov; 3(6).
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Rose S, Bennuri SC, Murray KF, Buie T, Winter H, Frye RE. Mitochondrial dysfunction in the gastrointestinal mucosa of children with autism: A blinded case-control study. PLoS One. 2017; 12(10):e0186377.
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Salter MW, Stevens B. Microglia emerge as central players in brain disease. Nat Med. 2017 Sep 08; 23(9):1018-1027.
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Constantino JN, Kennon-McGill S, Weichselbaum C, Marrus N, Haider A, Glowinski AL, Gillespie S, Klaiman C, Klin A, Jones W. Infant viewing of social scenes is under genetic control and is atypical in autism. Nature. 2017 07 20; 547(7663):340-344.
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Bourke J, Nembhard WN, Wong K, Leonard H. Twenty-Five Year Survival of Children with Intellectual Disability in Western Australia. J Pediatr. 2017 09; 188:232-239.e2.
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Kuhlthau KA, McDonnell E, Coury DL, Payakachat N, Macklin E. Associations of quality of life with health-related characteristics among children with autism. Autism. 2018 10; 22(7):804-813.
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Frye RE, Rose S, Wynne R, Bennuri SC, Blossom S, Gilbert KM, Heilbrun L, Palmer RF. Oxidative Stress Challenge Uncovers Trichloroacetaldehyde Hydrate-Induced Mitoplasticity in Autistic and Control Lymphoblastoid Cell Lines. Sci Rep. 2017 06 30; 7(1):4478.
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Shpyleva S, Melnyk S, Pavliv O, Pogribny I, Jill James S. Overexpression of LINE-1 Retrotransposons in Autism Brain. Mol Neurobiol. 2018 02; 55(2):1740-1749.
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Doshi P, Tilford JM, Ounpraseuth S, Kuo DZ, Payakachat N. Do Insurance Mandates Affect Racial Disparities in Outcomes for Children with Autism? Matern Child Health J. 2017 02; 21(2):351-366.
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Frye RE, Slattery J, Delhey L, Furgerson B, Strickland T, Tippett M, Sailey A, Wynne R, Rose S, Melnyk S, Jill James S, Sequeira JM, Quadros EV. Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial. Mol Psychiatry. 2018 02; 23(2):247-256.
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Homberg JR, Kyzar EJ, Nguyen M, Norton WH, Pittman J, Poudel MK, Gaikwad S, Nakamura S, Koshiba M, Yamanouchi H, Scattoni ML, Ullman JF, Diamond DM, Kaluyeva AA, Parker MO, Klimenko VM, Apryatin SA, Brown RE, Song C, Gainetdinov RR, Gottesman II, Kalueff AV. Understanding autism and other neurodevelopmental disorders through experimental translational neurobehavioral models. Neurosci Biobehav Rev. 2016 Jun; 65:292-312.
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Payakachat N, Tilford JM, Ungar WJ. National Database for Autism Research (NDAR): Big Data Opportunities for Health Services Research and Health Technology Assessment. Pharmacoeconomics. 2016 Feb; 34(2):127-38.
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Frye RE, Cox D, Slattery J, Tippett M, Kahler S, Granpeesheh D, Damle S, Legido A, Goldenthal MJ. Mitochondrial Dysfunction may explain symptom variation in Phelan-McDermid Syndrome. Sci Rep. 2016 Jan 29; 6:19544.
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Tilford JM, Payakachat N, Kuhlthau KA, Pyne JM, Kovacs E, Bellando J, Williams DK, Brouwer WB, Frye RE. Treatment for Sleep Problems in Children with Autism and Caregiver Spillover Effects. J Autism Dev Disord. 2015 Nov; 45(11):3613-23.
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Aman M, Rettiganti M, Nagaraja HN, Hollway JA, McCracken J, McDougle CJ, Tierney E, Scahill L, Arnold LE, Hellings J, Posey DJ, Swiezy NB, Ghuman J, Grados M, Shah B, Vitiello B. Tolerability, Safety, and Benefits of Risperidone in Children and Adolescents with Autism: 21-Month Follow-up After 8-Week Placebo-Controlled Trial. J Child Adolesc Psychopharmacol. 2015 Aug; 25(6):482-93.
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Bellando J, Fussell JJ, Lopez M. Autism Speaks Toolkits: Resources for Busy Physicians. Clin Pediatr (Phila). 2016 Feb; 55(2):171-5.
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