 Alanine Transaminase
"Alanine Transaminase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the conversion of L-alanine and 2-oxoglutarate to pyruvate and L-glutamate. (From Enzyme Nomenclature, 1992) EC 2.6.1.2.
| Descriptor ID |
D000410
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| MeSH Number(s) |
D08.811.913.477.700.100
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| Concept/Terms |
Alanine Transaminase- Alanine Transaminase
- Transaminase, Alanine
- Glutamic-Alanine Transaminase
- Glutamic Alanine Transaminase
- Transaminase, Glutamic-Alanine
- Alanine-2-Oxoglutarate Aminotransferase
- Alanine 2 Oxoglutarate Aminotransferase
- Aminotransferase, Alanine-2-Oxoglutarate
- Alanine Aminotransferase
- Aminotransferase, Alanine
- Glutamic-Pyruvic Transaminase
- Glutamic Pyruvic Transaminase
- Transaminase, Glutamic-Pyruvic
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Below are MeSH descriptors whose meaning is more general than "Alanine Transaminase".
Below are MeSH descriptors whose meaning is more specific than "Alanine Transaminase".
This graph shows the total number of publications written about "Alanine Transaminase" by people in UAMS Profiles by year, and whether "Alanine Transaminase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2025 | 0 | 1 | 1 | | 2024 | 0 | 1 | 1 | | 2023 | 0 | 1 | 1 | | 2021 | 0 | 2 | 2 | | 2020 | 2 | 0 | 2 | | 2019 | 0 | 2 | 2 | | 2018 | 1 | 1 | 2 | | 2016 | 0 | 5 | 5 | | 2015 | 0 | 4 | 4 | | 2014 | 3 | 6 | 9 | | 2013 | 1 | 3 | 4 | | 2012 | 1 | 8 | 9 | | 2011 | 0 | 4 | 4 | | 2010 | 0 | 1 | 1 | | 2009 | 1 | 3 | 4 | | 2008 | 1 | 2 | 3 | | 2007 | 0 | 2 | 2 | | 2006 | 1 | 1 | 2 | | 2005 | 1 | 1 | 2 | | 2004 | 0 | 4 | 4 | | 2003 | 0 | 1 | 1 | | 2002 | 0 | 2 | 2 | | 1999 | 0 | 1 | 1 | | 1996 | 0 | 1 | 1 | | 1994 | 0 | 1 | 1 |
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Below are the most recent publications written about "Alanine Transaminase" by people in Profiles over the past ten years.
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Aubrecht J, Potter D, Sauer JM, Warner R, Johnson KJ, McGill MR, Peron K, King NMP. Serum glutamate dehydrogenase activity enables sensitive and specific diagnosis of hepatocellular injury in humans. Toxicol Sci. 2025 Feb 01; 203(2):171-180.
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Kwon JH, Kang R, Lee SM, Hahm TS, Cho HS, Jin G, Ko JS. Effect of high-dose intravenous iron injection on hepatic function in a rat model of cirrhosis. J Int Med Res. 2024 May; 52(5):3000605241253733.
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Yiew NKH, Vazquez JH, Martino MR, Kennon-McGill S, Price JR, Allard FD, Yee EU, Layman AJ, James LP, McCommis KS, Finck BN, McGill MR. Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult. Mol Metab. 2023 Nov; 77:101808.
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Diaz EC, Weber JL, Adams SH, Young CG, Bai S, B?rsheim E. Cardiorespiratory Fitness Associates with Blood Pressure and Metabolic Health of Children-The Arkansas Active Kids Study. Med Sci Sports Exerc. 2021 11 01; 53(11):2225-2232.
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McGill MR, James LP, McCullough SS, Moran JH, Mathews SE, Peterson EC, Fleming DP, Tripod ME, Vazquez JH, Kennon-McGill S, Spencer HJ, Dranoff JA. Short-Term Safety of Repeated Acetaminophen Use in Patients With Compensated Cirrhosis. Hepatol Commun. 2022 02; 6(2):361-373.
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Smith AK, Ropella GEP, McGill MR, Krishnan P, Dutta L, Kennedy RC, Jaeschke H, Hunt CA. Contrasting model mechanisms of alanine aminotransferase (ALT) release from damaged and necrotic hepatocytes as an example of general biomarker mechanisms. PLoS Comput Biol. 2020 06; 16(6):e1007622.
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Vazquez JH, Clemens MM, Allard FD, Yee EU, Kennon-McGill S, Mackintosh SG, Jaeschke H, Hambuchen MD, McGill MR. Identification of Serum Biomarkers to Distinguish Hazardous and Benign Aminotransferase Elevations. Toxicol Sci. 2020 02 01; 173(2):244-254.
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Chiew AL, James LP, Isbister GK, Pickering JW, McArdle K, Chan BSH, Buckley NA. Early acetaminophen-protein adducts predict hepatotoxicity following overdose (ATOM-5). J Hepatol. 2020 03; 72(3):450-462.
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Jiang S, Vozmediano V, Abdel-Rahman SM, Schmidt S, James LP. Acetaminophen Protein Adducts in Hospitalized Children Receiving Multiple Doses of Acetaminophen. J Clin Pharmacol. 2019 10; 59(10):1291-1299.
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Green DM, Wang M, Krasin MJ, Srivastava D, Relling MV, Howell CR, Ness KK, Kaste SC, Greene W, Jay DW, Fernandez-Pineda I, Pui CH, Jeha S, Bishop MW, Furman WL, Robison LL, Hudson MM. Serum Alanine Aminotransferase Elevations in Survivors of Childhood Cancer: A Report From the St. Jude Lifetime Cohort Study. Hepatology. 2019 01; 69(1):94-106.
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Patel YA, Gifford EJ, Glass LM, Turner MJ, Han B, Moylan CA, Choi S, Suzuki A, Provenzale D, Hunt CM. Identifying Nonalcoholic Fatty Liver Disease Advanced Fibrosis in the Veterans Health Administration. Dig Dis Sci. 2018 09; 63(9):2259-2266.
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Gao Y, Cao Z, Yang X, Abdelmegeed MA, Sun J, Chen S, Beger RD, Davis K, Salminen WF, Song BJ, Mendrick DL, Yu LR. Proteomic analysis of acetaminophen-induced hepatotoxicity and identification of heme oxygenase 1 as a potential plasma biomarker of liver injury. Proteomics Clin Appl. 2017 01; 11(1-2).
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Weemhoff JL, Woolbright BL, Jenkins RE, McGill MR, Sharpe MR, Olson JC, Antoine DJ, Curry SC, Jaeschke H. Plasma biomarkers to study mechanisms of liver injury in patients with hypoxic hepatitis. Liver Int. 2017 03; 37(3):377-384.
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Shearn CT, Orlicky DJ, McCullough RL, Jiang H, Maclean KN, Mercer KE, Stiles BL, Saba LM, Ronis MJ, Petersen DR. Liver-Specific Deletion of Phosphatase and Tensin Homolog Deleted on Chromosome 10 Significantly Ameliorates Chronic EtOH-Induced Increases in Hepatocellular Damage. PLoS One. 2016; 11(4):e0154152.
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McGill MR, Kennon-McGill S, Durham D, Jaeschke H. Hearing, reactive metabolite formation, and oxidative stress in cochleae after a single acute overdose of acetaminophen: an in vivo study. Toxicol Mech Methods. 2016 Feb; 26(2):104-11.
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Maes M, McGill MR, da Silva TC, Lebofsky M, Maria Monteiro de Ara?jo C, Tiburcio T, Veloso Alves Pereira I, Willebrords J, Crespo Yanguas S, Farhood A, Zaidan Dagli ML, Jaeschke H, Cogliati B, Vinken M. Connexin32: a mediator of acetaminophen-induced liver injury? Toxicol Mech Methods. 2016 Feb; 26(2):88-96.
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Hu J, Ramshesh VK, McGill MR, Jaeschke H, Lemasters JJ. Low Dose Acetaminophen Induces Reversible Mitochondrial Dysfunction Associated with Transient c-Jun N-Terminal Kinase Activation in Mouse Liver. Toxicol Sci. 2016 Mar; 150(1):204-15.
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James L, Yan K, Pence L, Simpson P, Bhattacharyya S, Gill P, Letzig L, Kearns G, Beger R. Comparison of Bile Acids and Acetaminophen Protein Adducts in Children and Adolescents with Acetaminophen Toxicity. PLoS One. 2015; 10(7):e0131010.
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Hakkak R, Zeng H, Dhakal IB, Korourian S. Short- and Long-Term Soy Diet Versus Casein Protects Liver Steatosis Independent of the Arginine Content. J Med Food. 2015 Nov; 18(11):1274-80.
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Alonso EM, James LP, Zhang S, Squires RH. Acetaminophen Adducts Detected in Serum of Pediatric Patients With Acute Liver Failure. J Pediatr Gastroenterol Nutr. 2015 Jul; 61(1):102-7.
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