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Search Results to Susan Smyth

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One or more keywords matched the following properties of Smyth, Susan

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overview Inflammation and Thrombosis Program Drawing on a long-standing interest in platelet biology, our group has established animal models for studying the role of platelet membrane proteins in thrombosis and the response to arterial injury, and has delineated specific signaling systems responsible for mediating platelet-leukocyte interactions and for inflammation in the context of arterial injury and cardiac hypertrophy. We are interested in understanding the functional interplay between thrombosis and inflammation. Our work has resulted in observations about beneficial effects of antiplatelet drugs in infectious and inflammatory states of pneumonia and sepsis. This work has also spawned clinical trials of the effects of antithrombotic therapy on inflammation and the identification of biomarkers of ischemic heart disease. Current funded work continues to identify novel signaling pathways in platelets, which likely will be the target for future translational studies. Lysolipid Signaling Program Our group also has a longstanding research interest in the role of bioactive lysophospholipid, such as lysophosphatidic acid (LPA), as mediators of cardiovascular disease. The lysophospholipase D autotaxin (ATX) catalyzes the hydrolysis of circulating or cell-associated lysophosphatidylcholine (LPC) to generate LPA, which has potent, receptor-mediated effects on blood and vascular cells. LPA is a proteotypic member of a family of bioactive lipid phosphoric acids that function as receptor-active mediators with roles in cell growth, differentiation, apoptosis and development. Our contributions to the literature includes characterizing pathways for production and metabolism of LPA in the circulation; providing the first evidence of a pathologic role for LPA receptors in the response to arterial injury; identifying key structural and functional elements of ATX and mechanisms for regulation of ATX function by localization along cell surfaces; demonstrating roles for specific LPA receptors in experimental atherosclerosis. Current work is focused on identifying mechanistic links between dietary intake of lipids and cardiovascular disease risk. Current investigations are exploring the possibility that choline-containing lipids and adipose-derived ATX serve as links between diet and cardiovascular disease risk. LPA can hydrolyzed and inactivated by lipid phosphate phosphatase (LPP) enzymes present on cell membranes. A genome-wide association studies (GWAS) identified the PLPP3/PPAP2B gene encoding LPP3 as a novel loci associated with coronary artery disease susceptibility. We have established that LPP3 expression in mice is critical to attenuate inflammation, reduce smooth muscle cell proliferation, and maintain endothelial barrier function following vascular injury in an LPA-dependent manner. We have functionally validated that changes in LPP3 expression accelerates experimental atherosclerosis. Current studies are focused on understanding how heritable human variation in PLPP3 predisposes to the development of atherosclerosis and calcific aortic valve disease, which should translate identification of novel pathways for disease prevention. Active Funding: Serum Amyloid as a critical mediator between inflammation and thrombosis BSR&D Senior Clinical Scientist Award VA Merit I01BX004671 12/01/2019 - 9/30/2027 Smyth (PD/PI) This grant explores mechanisms by which inflammation activated platelet function and heightens thrombosis. Lysophosphatidic Acid and Cardiovascular Disease Risk VA Merit I01BX005637 4/01/2020 - 12/31/2024 Morris and Smyth (MPI) This grant seeks to understand the role of the ATX/LPA/LPP3 signaling nexus in the development of calcific aortic valve disease. Cardiovascular Health effects of per- and polyfluorinated alkyl substances in the Millennium Cohort MO2216/ Inter Agency Agreement 03/01/22-02/27/25 Morris (PI) Smyth (co-investigator) This study will compare circulating levels of PFAS in military firefighters and construction workers and examine the relationship between PFAS, circulating lipids, other cardiovascular disease risk determinants and health outcomes. Completed Awards as Principle Investigator: Project MISSION: Developing a multicomponent, Multilevel Implementation Strategy for Syncope OptImalCare thrOugh eNgagement NIH/NHLBI U01 HL143508 Li, Smyth, Williams (MPI) This is a hybrid implementation – dissemination strategy to improve adherence to guideline directed care for patients with syncope TL1 NRSA Training Core NIH/NCATS 1TL1TR001997 8/15/16-5/31/26 Smyth (PI) The objective of this grant is to train students, residents and fellows in clinical and translational research. After founding and successfully renewing the grant twice, I transferred it to another PI when I departed the institution in 2021. Lipid phosphate phosphatase 3 as a novel atherosclerosis suppressor NIH/NHLBI R01HL120507 4/01/15 – 3/31/21 Smyth and Morris (MPI) The goal of this study was to functionally validate PLPP3, encoding lipid phosphate phosphatase 3, as a novel protector from atherosclerosis. Clinical Scholars in Cardiovascular Science Training Grant NIH/NHLBI T32HL091812 6/1/08 – 5/31/19 Smyth (PI) The objective of this grant is to train clinicians (MD, PharmD, RN/PhD) to become independent cardiovascular scientists. Adipose autotoxin and lysophosphatidic acid signaling VA Merit Award BX002769 10/1/2014 – 9/30/2019 Smyth (PI) The goal of this study was to study the role of adipose-derived autotoxin as a novel mediator of cardiovascular disease

One or more keywords matched the following items that are connected to Smyth, Susan

Item TypeName
Concept Cell Communication
Concept Cell Movement
Concept Cell Count
Concept Cell Membrane
Concept Cell Division
Concept Cell Fractionation
Concept Anemia, Sickle Cell
Concept Blood Cell Count
Concept Cell Adhesion
Concept Cells, Cultured
Concept Cell Aggregation
Concept Cell Differentiation
Concept Cell Separation
Concept Bone Marrow Cells
Concept HeLa Cells
Concept Hematopoietic Stem Cells
Concept Hematopoietic Stem Cell Transplantation
Concept Cell Hypoxia
Concept Cell Line
Concept Cell Adhesion Molecules
Concept Cell Proliferation
Concept Foam Cells
Concept HEK293 Cells
Concept Mast Cells
Concept Endothelial Cells
Concept Cell Line, Tumor
Concept Cell Fusion
Concept Stem Cells
Concept Tumor Cells, Cultured
Concept Hematopoietic Stem Cell Mobilization
Concept CHO Cells
Concept Pluripotent Stem Cells
Concept Cell-Derived Microparticles
Concept Active Transport, Cell Nucleus
Academic Article Mice with targeted inactivation of ppap2b in endothelial and hematopoietic cells display enhanced vascular inflammation and permeability.
Academic Article Functional characterization of the atypical integral membrane lipid phosphatase PDP1/PPAPDC2 identifies a pathway for interconversion of isoprenols and isoprenoid phosphates in mammalian cells.
Academic Article Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation.
Academic Article A phosphatidic acid binding/nuclear localization motif determines lipin1 function in lipid metabolism and adipogenesis.
Academic Article Pharmacological Elevation of Circulating Bioactive Phosphosphingolipids Enhances Myocardial Recovery After Acute Infarction.
Academic Article Plasma levels of sphingosine 1-phosphate are strongly correlated with haematocrit, but variably restored by red blood cell transfusions.
Academic Article Binding of autotaxin to integrins localizes lysophosphatidic acid production to platelets and mammalian cells.
Academic Article Synergistic effect of anemia and red blood cells transfusion on inflammation and lung injury.
Academic Article Autotaxin and its product lysophosphatidic acid suppress brown adipose differentiation and promote diet-induced obesity in mice.
Academic Article The P2Y(12) antagonists, 2MeSAMP and cangrelor, inhibit platelet activation through P2Y(12)/G(i)-dependent mechanism.
Academic Article Lipid phosphate phosphatase 3 negatively regulates smooth muscle cell phenotypic modulation to limit intimal hyperplasia.
Academic Article Mechanism of rapid elimination of lysophosphatidic acid and related lipids from the circulation of mice.
Academic Article Bioactive lipids and cationic antimicrobial peptides as new potential regulators for trafficking of bone marrow-derived stem cells in patients with acute myocardial infarction.
Academic Article Autotaxin inhibition reduces cardiac inflammation and mitigates adverse cardiac remodeling after myocardial infarction.
Academic Article Roles for lysophosphatidic acid signaling in vascular development and disease.
Academic Article Lysophospholipids and their receptors: New data and new insights into their function.
Academic Article Coronary Artery Disease Risk-Associated Plpp3 Gene and Its Product Lipid Phosphate Phosphatase 3 Regulate Experimental Atherosclerosis.
Academic Article Regulation of PLPP3 gene expression by NF-?B family transcription factors.
Academic Article Inflammasome Activation Triggers Blood Clotting and Host Death through Pyroptosis.
Academic Article LPA receptor 4 deficiency attenuates experimental atherosclerosis.
Academic Article Autotaxin exacerbates tumor progression by enhancing MEK1 and overriding the function of miR-489-3p.
Academic Article Translational Implications of Platelets as Vascular First Responders.
Academic Article Comparison of Outcomes in Patients Having Acute Myocardial Infarction With Versus Without Sickle-Cell Anemia.
Academic Article Anti-Thrombotic Effects of Statins in Acute Coronary Syndromes: At the Intersection of Thrombosis, Inflammation, and Platelet-Leukocyte Interactions.
Academic Article Thromboinflammatory response and predictors of outcomes in patients undergoing transcatheter aortic valve replacement.
Academic Article Characterization of a Novel Integrin Binding Protein, VPS33B, Which Is Important for Platelet Activation and In Vivo Thrombosis and Hemostasis.
Academic Article Lipid-induced epigenomic changes in human macrophages identify a coronary artery disease-associated variant that regulates PPAP2B Expression through Altered C/EBP-beta binding.
Academic Article Lysophospholipid mediators in the vasculature.
Academic Article The effect of rosuvastatin on platelet-leukocyte interactions in the setting of acute coronary syndrome.
Academic Article The effect of rosuvastatin on thromboinflammation in the setting of acute coronary syndrome.
Academic Article Platelet secretion and hemostasis require syntaxin-binding protein STXBP5.
Academic Article Granule cargo release from bone marrow-derived cells sustains cardiac hypertrophy.
Academic Article Adipose tissue macrophages promote myelopoiesis and monocytosis in obesity.
Academic Article Effects of vorapaxar on platelet reactivity and biomarker expression in non-ST-elevation acute coronary syndromes. The TRACER Pharmacodynamic Substudy.
Academic Article Integrin-mediated cell surface recruitment of autotaxin promotes persistent directional cell migration.
Academic Article Lysophosphatidic acid and cardiovascular disease: seeing is believing.
Academic Article Coronary artery remodeling in a model of left ventricular pressure overload is influenced by platelets and inflammatory cells.
Academic Article Autotaxin induces lung epithelial cell migration through lysoPLD activity-dependent and -independent pathways.
Academic Article Structural basis of substrate discrimination and integrin binding by autotaxin.
Academic Article Evidence of mobilization of pluripotent stem cells into peripheral blood of patients with myocardial ischemia.
Academic Article A G(i) -independent mechanism mediating Akt phosphorylation in platelets.
Academic Article Enhanced proliferation and migration of vascular smooth muscle cells in response to vascular injury under hyperglycemic conditions is controlled by beta3 integrin signaling.
Academic Article Periostin mediates vascular smooth muscle cell migration through the integrins alphavbeta3 and alphavbeta5 and focal adhesion kinase (FAK) pathway.
Academic Article Platelet functions beyond hemostasis.
Academic Article Regulation of blood and vascular cell function by bioactive lysophospholipids.
Academic Article Platelet function analysis: at the edge of meaning.
Academic Article Dominant-negative loss of PPARgamma function enhances smooth muscle cell proliferation, migration, and vascular remodeling.
Academic Article Lysophosphatidic acid receptors 1 and 2 play roles in regulation of vascular injury responses but not blood pressure.
Academic Article Measurement of autotaxin/lysophospholipase D activity.
Academic Article Src family kinases mediate neutrophil adhesion to adherent platelets.
Academic Article CX3CR1 deficiency confers protection from intimal hyperplasia after arterial injury.
Academic Article Src-family kinases mediate an outside-in signal necessary for beta2 integrins to achieve full activation and sustain firm adhesion of polymorphonuclear leucocytes tethered on E-selectin.
Academic Article Effects of thrombin on interactions between beta3-integrins and extracellular matrix in platelets and vascular cells.
Academic Article Lipid phosphate phosphatases regulate lysophosphatidic acid production and signaling in platelets: studies using chemical inhibitors of lipid phosphate phosphatase activity.
Academic Article Alphavbeta3-integrin antagonists inhibit thrombin-induced proliferation and focal adhesion formation in smooth muscle cells.
Academic Article Tiny dancers: the integrin-growth factor nexus in angiogenic signaling.
Academic Article Preparation of monoclonal antibodies to murine platelet glycoprotein IIb/IIIa (alphaIIbbeta3) and other proteins from hamster-mouse interspecies hybridomas.
Academic Article Human umbilical vein endothelial cells possess binding sites for the globular domain of C1q.
Academic Article Regulation of ligand binding to glycoprotein IIb-IIIa (integrin alpha IIb beta 3) in isolated platelet membranes.
Academic Article Regulation of vascular integrins.
Academic Article Fibrinogen binding to purified platelet glycoprotein IIb-IIIa (integrin alpha IIb beta 3) is modulated by lipids.
Academic Article Phospholipase Cgamma activation drives increased production of autotaxin in endothelial cells and lysophosphatidic acid-dependent regression.
Academic Article Novel critical role of Toll-like receptor 4 in lung ischemia-reperfusion injury and edema.
Academic Article Lipid phosphate phosphatase 3 in smooth muscle cells regulates angiotensin II-induced abdominal aortic aneurysm formation.
Academic Article Extracellular Histones Trigger Disseminated Intravascular Coagulation by Lytic Cell Death.

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