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Mourani, Peter

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research overview

My overall research focus has been the identification of mechanisms and biomarkers of acute lung disease in critically ill neonates, infants, and children. Specifically, I have had two research foci: 1) Developmental lung and lung vascular disease in infants who are born extremely premature; and 2) Lower respiratory tract infections, including ventilator-associated-pneumonia in critically ill children requiring mechanical ventilator support. While seemingly disparate topics, these two foci have capitalized on the breadth of my training as both a pulmonologist and critical care physician and collaboration with multi-disciplinary scientific teams to obtain a consistent level of funded projects (including NIH R and U mechanisms) and produce impactful results. In addition to serving as principal investigator (PI) for funded projects in these focused areas, I serve as the site PI and Steering Committee member for the prestigious NICHD supported Collaborative Pediatric Critical Care Research Network (CPCCRN), which performs meaningful clinical research in the field of pediatric critical illness and injury. I am a key member of the team that designed the Personalized Immunomodulation in Pediatric Sepsis-induced MODS (PRECISE) for the upcoming cycle of CPCCRN, which will be among the first personalized medicine trials in pediatric critical care.

One or more keywords matched the following items that are connected to Mourani, Peter

Item Type	Name
Concept	Aftercare
Concept	Coronary Care Units
Concept	Critical Care
Concept	Intensive Care Units, Neonatal
Concept	Intensive Care, Neonatal
Concept	Intensive Care Units
Concept	Treatment Outcome
Concept	Point-of-Care Systems
Concept	Patient Care Team
Concept	Intensive Care Units, Pediatric
Concept	Tertiary Care Centers
Academic Article	Characteristics and Outcomes of US Children and Adolescents With Multisystem Inflammatory Syndrome in Children (MIS-C) Compared With Severe Acute COVID-19.
Grant	The Microbiome, Virome and Host Responses Preceding Ventilator-Associated Pneumon
Grant	Collaborative Network Study of Airway Microbiome and Host Responses in Pediatric Respiratory Failure
Grant	Pathogenetic Mechanisms of Brochopulmonary Dysplasia
Academic Article	Proteomic Profiles Associated with Early Echocardiogram Evidence of Pulmonary Vascular Disease in Preterm Infants.
Academic Article	Specific Viral Etiologies Are Associated With Outcomes in Pediatric Acute Respiratory Distress Syndrome.
Academic Article	Genomic Insights into Respiratory Outcomes after Preterm Birth.
Academic Article	Ventilator-Associated Pneumonia in Critically Ill Children: A New Paradigm.
Academic Article	The role of vitamin D in prevention and treatment of infection.
Academic Article	Complicated Grief, Depression and Post-Traumatic Stress Symptoms Among Bereaved Parents following their Child's Death in the Pediatric Intensive Care Unit: A Follow-Up Study.
Academic Article	A comparison of characteristics and outcomes in severe human metapneumovirus and respiratory syncytial virus infections in children treated in an intensive care unit.
Academic Article	Factors Associated With Functional Impairment After Pediatric Injury.
Academic Article	Reply to Ong and Schechter: Is It Acceptable to Assess Prenatal Smoking Risk to Infants without Considering Socioeconomic Status?
Academic Article	Early pulmonary vascular disease in preterm infants at risk for bronchopulmonary dysplasia.
Academic Article	Hospital Readmissions After Pediatric Trauma.
Academic Article	Delirium is a Common and Early Finding in Patients in the Pediatric Cardiac Intensive Care Unit.
Academic Article	Hyperchloremia is independently associated with mortality in critically ill children who ultimately require continuous renal replacement therapy.
Academic Article	Intensive care unit readmission during childhood after preterm birth with respiratory failure.
Academic Article	Improving outcomes after pediatric cardiac arrest - the ICU-Resuscitation Project: study protocol for a randomized controlled trial.
Academic Article	Antenatal Determinants of Bronchopulmonary Dysplasia and Late Respiratory Disease in Preterm Infants.
Academic Article	Critical Illness Factors Associated With Long-Term Mortality and Health-Related Quality of Life Morbidity Following Community-Acquired Pediatric Septic Shock.
Academic Article	Trajectory of Mortality and Health-Related Quality of Life Morbidity Following Community-Acquired Pediatric Septic Shock.
Academic Article	Pulmonary vascular effects of inhaled nitric oxide and oxygen tension in bronchopulmonary dysplasia.
Academic Article	Effectiveness of influenza vaccine against life-threatening RT-PCR-confirmed influenza illness in US children, 2010-2012.
Academic Article	Development of a core outcome set for pediatric critical care outcomes research.
Academic Article	Effects of hyperchloremia on renal recovery in critically ill children with acute kidney injury.
Academic Article	Inhaled Nitric Oxide Use in Pediatric Hypoxemic Respiratory Failure.
Academic Article	Molecular analysis of endotracheal tube biofilms and tracheal aspirates in the pediatric intensive care unit.
Academic Article	Increase in chloride from baseline is independently associated with mortality in critically ill children.
Academic Article	Effects of long-term sildenafil treatment for pulmonary hypertension in infants with chronic lung disease.
Academic Article	Longitudinal Trajectories of Caregiver Distress and Family Functioning After Community-Acquired Pediatric Septic Shock.
Academic Article	Severe Acute Kidney Injury Is Associated With Increased Risk of Death and New Morbidity After Pediatric Septic Shock.
Academic Article	Design and Rationale for Common Data Elements for Clinical Research in Pediatric Critical Care Medicine.
Academic Article	Trajectories and Risk Factors for Altered Physical and Psychosocial Health-Related Quality of Life After Pediatric Community-Acquired Septic Shock.
Academic Article	Cord blood angiogenic progenitor cells are decreased in bronchopulmonary dysplasia.
Academic Article	Biomarkers for Estimating Risk of Hospital Mortality and Long-Term Quality-of-Life Morbidity After Surviving Pediatric Septic Shock: A Secondary Analysis of the Life After Pediatric Sepsis Evaluation Investigation.
Academic Article	Temporal airway microbiome changes related to ventilator-associated pneumonia in children.
Academic Article	Postdischarge Outcome Domains in Pediatric Critical Care and the Instruments Used to Evaluate Them: A Scoping Review.
Academic Article	Early Pulmonary Vascular Disease in Preterm Infants Is Associated with Late Respiratory Outcomes in Childhood.
Academic Article	Therapeutic Alliance Between Bereaved Parents and Physicians in the PICU.
Academic Article	Treatment, survival, and thromboembolic outcomes of thrombotic storm in children.
Academic Article	Intensive care management of right ventricular failure and pulmonary hypertension crises.
Academic Article	A Population Pharmacokinetic Analysis to Study the Effect of Extracorporeal Membrane Oxygenation on Cefepime Disposition in Children.
Academic Article	Metabolomic Fingerprinting of Infants Undergoing Cardiopulmonary Bypass: Changes in Metabolic Pathways and Association With Mortality and Cardiac Intensive Care Unit Length of Stay.
Academic Article	A Core Outcome Set for Pediatric Critical Care.
Academic Article	Health-Related Quality of Life After Community-Acquired Septic Shock in Children With Preexisting Severe Developmental Disabilities.
Academic Article	Cardiac findings and long-term thromboembolic outcomes following pulmonary embolism in children: a combined retrospective-prospective inception cohort study.
Academic Article	Short-Term Adverse Outcomes Associated With Hypoglycemia in Critically Ill Children.
Academic Article	Arteriopathy, D-dimer, and risk of poor neurologic outcome in childhood-onset arterial ischemic stroke.
Academic Article	Application of the New Centers for Disease Control and Prevention Surveillance Criteria for Ventilator-Associated Events to a Cohort of PICU Patients Identifies Different Patients Compared With the Previous Definition and Physician Diagnosis.
Academic Article	Scope and impact of early and late preterm infants admitted to the PICU with respiratory illness.
Academic Article	Preventing Underfeeding and Overfeeding: A Clinician's Guide to the Acquisition and Implementation of Indirect Calorimetry.
Grant	Collaborative Pediatric Critical Care Research Network - Clinical Site
Academic Article	Post-Traumatic Growth in Parents following Their Child's Death in a Pediatric Intensive Care Unit.
Academic Article	Inhaled Nitric Oxide Use and Outcomes in Critically Ill Children With a History of Prematurity.
Academic Article	Mechanical power in pediatric acute respiratory distress syndrome: a PARDIE study.
Academic Article	Health Resource Use in Survivors of Pediatric Septic Shock in the United States.
Academic Article	Identifying Long-Term Morbidities and Health Trajectories After Prolonged Mechanical Ventilation in Children Using State All Payer Claims Data.
Academic Article	Effect of Physiologic Point-of-Care Cardiopulmonary Resuscitation Training on Survival With Favorable Neurologic Outcome in Cardiac Arrest in Pediatric ICUs: A Randomized Clinical Trial.
Academic Article	Characterization of Inhaled Nitric Oxide Use for Cardiac Indications in Pediatric Patients.
Academic Article	Complement Activation Fragments Are Increased in Critically Ill Pediatric Patients with Severe AKI.
Academic Article	Postdischarge health resource use in pediatric survivors of prolonged mechanical ventilation for acute respiratory illness.
Academic Article	Peripheral Vasoactive Administration in Critically Ill Children With Shock: A Single-Center Retrospective Cohort Study.
Academic Article	Assessment of Patient Health-Related Quality of Life and Functional Outcomes in Pediatric Acute Respiratory Distress Syndrome.
Academic Article	Post-discharge rehabilitation and functional recovery after pediatric injury.
Academic Article	Association of Pathogen Type With Outcomes of Children Encountering Community-Acquired Pediatric Septic Shock.
Academic Article	The Association of Early Corticosteroid Therapy With Clinical and Health-Related Quality of Life Outcomes in Children With Septic Shock.
Academic Article	Sodium Bicarbonate Use During Pediatric Cardiopulmonary Resuscitation: A Secondary Analysis of the ICU-RESUScitation Project Trial.
Academic Article	The Temporal Association of the COVID-19 Pandemic and Pediatric Cardiopulmonary Resuscitation Quality and Outcomes.
Academic Article	The Association between Therapeutic Alliance and Parental Health Outcomes following a Child's Death in the Pediatric Intensive Care Unit.
Academic Article	Diastolic Blood Pressure Threshold During Pediatric Cardiopulmonary Resuscitation and Survival Outcomes: A Multicenter Validation Study.
Academic Article	The Design of Nested Adaptive Clinical Trials of Multiple Organ Dysfunction Syndrome Children in a Single Study.
Academic Article	Fluid Balance and Its Association With Mortality and Health-Related Quality of Life: A Nonprespecified Secondary Analysis of the Life After Pediatric Sepsis Evaluation.
Academic Article	Outcomes and characteristics of cardiac arrest in children with pulmonary hypertension: A secondary analysis of the ICU-RESUS clinical trial.
Academic Article	Viral Detection by Reverse Transcriptase Polymerase Chain Reaction in Upper Respiratory Tract and Metagenomic RNA Sequencing in Lower Respiratory Tract in Critically Ill Children With Suspected Lower Respiratory Tract Infection.
Academic Article	Endothelial Glycocalyx Degradation Patterns in Sepsis-Associated Pediatric Acute Respiratory Distress Syndrome: A Single Center Retrospective Observational Study.
Academic Article	Survival With Favorable Neurologic Outcome and Quality of Cardiopulmonary Resuscitation Following In-Hospital Cardiac Arrest in Children With Cardiac Disease Compared With Noncardiac Disease.
Academic Article	Identification of post-cardiac arrest blood pressure thresholds associated with outcomes in children: an ICU-Resuscitation study.
Academic Article	Early Cardiac Arrest Hemodynamics, End-Tidal Co2, and Outcome in Pediatric Extracorporeal Cardiopulmonary Resuscitation: Secondary Analysis of the ICU-RESUScitation Project Dataset (2016-2021).
Academic Article	Utility of Early Magnetic Resonance Imaging to Enhance Outcome Prediction in Critically Ill Children with Severe Traumatic Brain Injury.
Academic Article	Recovery Trajectories in Children Requiring 3 or More Days of Invasive Ventilation.
Academic Article	Association of an In-Hospital Desirability of Outcomes Ranking Scale With Postdischarge Health-Related Quality of Life: A Secondary Analysis of the Life After Pediatric Sepsis Evaluation.
Academic Article	Healthcare Burden and Resource Utilization After Pediatric Acute Respiratory Distress Syndrome: A Secondary Analysis of the Collaborative Pediatric Critical Care Research Network Acute Respiratory Distress Syndrome Study.

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Aftercare