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Search Results to Mitchell Mcgill

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Mcgill, Mitchell

One or more keywords matched the following items that are connected to Mcgill, Mitchell

Item Type	Name
Concept	Acetaminophen
Academic Article	Lipin deactivation after acetaminophen overdose causes phosphatidic acid accumulation in liver and plasma in mice and humans and enhances liver regeneration.
Academic Article	Removal of acetaminophen protein adducts by autophagy protects against acetaminophen-induced liver injury in mice.
Academic Article	Inhibition of pannexin1 channels alleviates acetaminophen-induced hepatotoxicity.
Academic Article	Plasma biomarkers to study mechanisms of liver injury in patients with hypoxic hepatitis.
Academic Article	Acetaminophen-induced liver injury in rats and mice: comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity.
Academic Article	Modulation of O-GlcNAc Levels in the Liver Impacts Acetaminophen-Induced Liver Injury by Affecting Protein Adduct Formation and Glutathione Synthesis.
Academic Article	Involvement of connexin43 in acetaminophen-induced liver injury.
Academic Article	Cytochrome P450-derived versus mitochondrial oxidant stress in acetaminophen hepatotoxicity.
Academic Article	Low Dose Acetaminophen Induces Reversible Mitochondrial Dysfunction Associated with Transient c-Jun N-Terminal Kinase Activation in Mouse Liver.
Academic Article	Lack of Direct Cytotoxicity of Extracellular ATP against Hepatocytes: Role in the Mechanism of Acetaminophen Hepatotoxicity.
Academic Article	Pathophysiological relevance of neutrophils in acetaminophen hepatotoxicity.
Academic Article	Differences in early acetaminophen hepatotoxicity between obese ob/ob and db/db mice.
Academic Article	Purinergic receptor antagonist A438079 protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes, not by inflammasome activation.
Academic Article	Mechanistic biomarkers in acetaminophen-induced hepatotoxicity and acute liver failure: from preclinical models to patients.
Academic Article	Erratum to: Inhibition of pannexin1 channels alleviates acetaminophen-induced hepatotoxicity.
Academic Article	Mechanisms of acetaminophen-induced cell death in primary human hepatocytes.
Academic Article	Acetaminophen-induced Liver Injury: from Animal Models to Humans.
Academic Article	Resveratrol prevents protein nitration and release of endonucleases from mitochondria during acetaminophen hepatotoxicity.
Academic Article	Neutrophil activation during acetaminophen hepatotoxicity and repair in mice and humans.
Academic Article	Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans.
Academic Article	The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation.
Academic Article	Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: dose-response, mechanisms, and clinical implications.
Academic Article	A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: Application to acetaminophen.
Academic Article	Hearing, reactive metabolite formation, and oxidative stress in cochleae after a single acute overdose of acetaminophen: an in vivo study.
Academic Article	Caveats of using acetaminophen hepatotoxicity models for natural product testing.
Academic Article	Lysosomal instability and cathepsin B release during acetaminophen hepatotoxicity.
Academic Article	Acetaminophen is both bronchodilatory and bronchoprotective in human precision cut lung slice airways.
Academic Article	Lower susceptibility of female mice to acetaminophen hepatotoxicity: Role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase.
Academic Article	Pathophysiological significance of c-jun N-terminal kinase in acetaminophen hepatotoxicity.
Academic Article	Pathophysiological relevance of proteomics investigations of drug-induced hepatotoxicity in HepG2 cells.
Academic Article	Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis.
Academic Article	HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity.
Academic Article	Apoptosis or necrosis in acetaminophen-induced acute liver failure? New insights from mechanistic biomarkers*.
Academic Article	Herbal extracts as hepatoprotectants against acetaminophen hepatotoxicity.
Academic Article	Platelets and protease-activated receptor-4 contribute to acetaminophen-induced liver injury in mice.
Academic Article	Serum mitochondrial biomarkers and damage-associated molecular patterns are higher in acetaminophen overdose patients with poor outcome.
Academic Article	Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury.
Academic Article	Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity.
Academic Article	RETRACTED: Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity.
Academic Article	Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice.
Academic Article	The gap junction inhibitor 2-aminoethoxy-diphenyl-borate protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes and c-jun N-terminal kinase activation.
Academic Article	Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity.
Academic Article	Fas receptor-deficient lpr mice are protected against acetaminophen hepatotoxicity due to higher glutathione synthesis and enhanced detoxification of oxidant stress.
Academic Article	Glycodeoxycholic acid levels as prognostic biomarker in acetaminophen-induced acute liver failure patients.
Academic Article	Dual Role of Epidermal Growth Factor Receptor in Liver Injury and Regeneration after Acetaminophen Overdose in Mice.
Academic Article	Time course of acetaminophen-protein adducts and acetaminophen metabolites in circulation of overdose patients and in HepaRG cells.
Academic Article	Current issues with acetaminophen hepatotoxicity--a clinically relevant model to test the efficacy of natural products.
Academic Article	Benzyl alcohol protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes but causes mitochondrial dysfunction and cell death at higher doses.
Academic Article	Argininosuccinate synthetase as a plasma biomarker of liver injury after acetaminophen overdose in rodents and humans.
Academic Article	Circulating microRNA profiles in human patients with acetaminophen hepatotoxicity or ischemic hepatitis.
Academic Article	Protection against acetaminophen-induced liver injury by allopurinol is dependent on aldehyde oxidase-mediated liver preconditioning.
Academic Article	Connexin32: a mediator of acetaminophen-induced liver injury?
Academic Article	The inhibitor of glycerol 3-phosphate acyltransferase FSG67 blunts liver regeneration after acetaminophen overdose by altering GSK3? and Wnt/?-catenin signaling.
Academic Article	Propagation of Pericentral Necrosis During Acetaminophen-Induced Liver Injury: Evidence for Early Interhepatocyte Communication and Information Exchange.
Academic Article	Lack of direct cytotoxicity of extracellular ATP against hepatocytes: role in the mechanism of acetaminophen hepatotoxicity.
Academic Article	Extrahepatic toxicity of acetaminophen: critical evaluation of the evidence and proposed mechanisms.
Academic Article	Animal models of drug-induced liver injury.
Academic Article	Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration.
Academic Article	Granzyme B and miR-378a Interaction in Acetaminophen Toxicity in Children.
Academic Article	Identification of Serum Biomarkers to Distinguish Hazardous and Benign Aminotransferase Elevations.
Academic Article	Contrasting model mechanisms of alanine aminotransferase (ALT) release from damaged and necrotic hepatocytes as an example of general biomarker mechanisms.
Academic Article	Advances in biomarker development in acetaminophen toxicity.
Academic Article	Pre-treatment twice with liposomal clodronate protects against acetaminophen hepatotoxicity through a pre-conditioning effect.
Academic Article	Retraction notice to "Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity": J Hepatol 56(2012)1070-1079.
Academic Article	The development and hepatotoxicity of acetaminophen: reviewing over a century of progress.
Academic Article	Short-Term Safety of Repeated Acetaminophen Use in Patients With Compensated Cirrhosis.
Academic Article	Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk.
Academic Article	Proteomics Indicates Lactate Dehydrogenase Is Prognostic in Acetaminophen-Induced Acute Liver Failure Patients and Reveals Altered Signaling Pathways.
Academic Article	Generation of pro-and anti-inflammatory mediators after acetaminophen overdose in surviving and non-surviving patients.
Academic Article	Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult.
Academic Article	The Role of Mechanistic Biomarkers in Understanding Acetaminophen Hepatotoxicity in Humans.
Grant	In-vitro assessment of the protective effects of selected ingredients against acetaminophen hepatotoxicity
Academic Article	The Evolution of Circulating Biomarkers for Use in Acetaminophen/Paracetamol-Induced Liver Injury in Humans: A Scoping Review.
Grant	The role of phosphatidic acid in liver regeneration after acetaminophen overdose
Academic Article	Natural Products That Protect Against Acetaminophen Hepatotoxicity: A Call for Increased Rigor in Preclinical Studies of Dietary Supplements.

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Acetaminophen