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Search Results to Ryan Porter

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Porter, Ryan

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Articular Cartilage

overview

The Porter lab focuses on developing strategies to prevent articular cartilage degeneration or stimulate cartilage repair. Currently, his group is pursuing two areas of research: one focused on improving the intra-articular delivery of therapeutics within synovial joints to prevent or treat osteoarthritis; the other on overcoming key bottlenecks to stimulating chondrogenesis within skeletal defects. These projects use mouse, rat, and rabbit models of bone and joint injury to help answer specific research questions. This work has been supported by grants from the National Institutes of Health, the Klarman Family Foundation, the UAMS Bone and Joint Initiative, and the Arkansas Biosciences Institute.

One or more keywords matched the following items that are connected to Porter, Ryan

Item Type	Name
Concept	Cartilage
Concept	Cartilage Diseases
Concept	Cartilage, Articular
Academic Article	Use of genetically modified muscle and fat grafts to repair defects in bone and cartilage.
Academic Article	Alginate encapsulation impacts the insulin-like growth factor-I system of monolayer-expanded equine articular chondrocytes and cell response to interleukin-1beta.
Academic Article	A rabbit model demonstrates the influence of cartilage thickness on intra-articular drug delivery and retention within cartilage.
Academic Article	Transcriptional and proteolytic regulation of the insulin-like growth factor-I system of equine articular chondrocytes by recombinant equine interleukin-1beta.
Academic Article	Effects of Dexamethasone on Mesenchymal Stromal Cell Chondrogenesis and Aggrecanase Activity: Comparison of Agarose and Self-Assembling Peptide Scaffolds.
Academic Article	Electrostatic interactions enable rapid penetration, enhanced uptake and retention of intra-articular injected avidin in rat knee joints.
Academic Article	Sustained intra-cartilage delivery of low dose dexamethasone using a cationic carrier for treatment of post traumatic osteoarthritis.
Grant	A Transgenic Rat for Noninvasive Assessment of Chondrogenic Activity in vivo
Academic Article	Interleukin-1 receptor antagonist (IL-1Ra) is more effective in suppressing cytokine-induced catabolism in cartilage-synovium co-culture than in cartilage monoculture.
Academic Article	Multi-arm Avidin nano-construct for intra-cartilage delivery of small molecule drugs.
Grant	Intra-cartilage depot delivery of electrically-charged IL-1RA for targeting osteoarthritis-associated inflammation and catabolism in multiple joint tissues
Academic Article	A Transgenic Rat for Noninvasive Assessment of Chondrogenesis in Vivo.
Academic Article	Intra-articular kinetics of a cartilage targeting cationic PEGylated protein for applications in drug delivery.

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Cartilage