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Search Results to Brendan Frett

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Frett, Brendan

One or more keywords matched the following items that are connected to Frett, Brendan

Item Type	Name
Concept	fms-Like Tyrosine Kinase 3
Concept	Protein Kinase Inhibitors
Academic Article	Targeting mutant KRAS for anticancer therapeutics: a review of novel small molecule modulators.
Academic Article	Fragment-Based Discovery of a Dual pan-RET/VEGFR2 Kinase Inhibitor Optimized for Single-Agent Polypharmacology.
Academic Article	Computer aided drug discovery of highly ligand efficient, low molecular weight imidazopyridine analogs as FLT3 inhibitors.
Academic Article	Identification of two novel RET kinase inhibitors through MCR-based drug discovery: design, synthesis and evaluation.
Academic Article	Therapeutic melting pot of never in mitosis gene a related kinase 2 (Nek2): a perspective on Nek2 as an oncology target and recent advancements in Nek2 small molecule inhibition.
Academic Article	Structure-based design and synthesis of imidazo[1,2-a]pyridine derivatives as novel and potent Nek2 inhibitors with in?vitro and in?vivo antitumor activities.
Academic Article	Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2.
Academic Article	Rational Design, Synthesis and Biological Evaluation of Pyrimidine-4,6-diamine derivatives as Type-II inhibitors of FLT3 Selective Against c-KIT.
Academic Article	Insights into Current Tropomyosin Receptor Kinase (TRK) Inhibitors: Development and Clinical Application.
Grant	Selective RET Kinase and Its Mutant Inhibitors for the Treatment of Medullary Thyroid Cancer
Academic Article	The Exploration of Chirality for Improved Druggability within the Human Kinome.
Academic Article	Structural Characterization of the Aurora Kinase B "DFG-flip" Using Metadynamics.
Academic Article	Bioisosteric Discovery of NPA101.3, a Second-Generation RET/VEGFR2 Inhibitor Optimized for Single-Agent Polypharmacology.
Academic Article	Discovery of SP-96, the first non-ATP-competitive Aurora Kinase B inhibitor, for reduced myelosuppression.
Academic Article	Pyrrolo[2,3-d]pyrimidine derivatives as inhibitors of RET: Design, synthesis and biological evaluation.
Academic Article	Correction to Insights into Current Tropomyosin Receptor Kinase (TRK) Inhibitors: Development and Clinical Application.
Academic Article	Pyrazoloadenine Inhibitors of the RET Lung Cancer Oncoprotein Discovered by a Fragment Optimization Approach.
Academic Article	Discovery of pyrazolo-thieno[3,2-d]pyrimidinylamino-phenyl acetamides as type-II pan-tropomyosin receptor kinase (TRK) inhibitors: Design, synthesis, and biological evaluation.
Academic Article	Discovery and biological evaluation of phthalazines as novel non-kinase TGF? pathway inhibitors.
Academic Article	Targeted activity of the small molecule kinase inhibitor Pz-1 towards RET and TRK kinases.
Academic Article	Targeting Rearranged during Transfection in Cancer: A Perspective on Small-Molecule Inhibitors and Their Clinical Development.
Academic Article	Discovery of 4-aminoquinolines as highly selective TGF?R1 inhibitors with an attenuated MAP4K4 profile for potential applications in immuno-oncology.
Academic Article	Discovery of imidazo[1,2-a]pyridine-thiophene derivatives as FLT3 and FLT3 mutants inhibitors for acute myeloid leukemia through structure-based optimization of an NEK2 inhibitor.
Academic Article	Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose.
Academic Article	An updated patent review of rearranged during transfection (RET) kinase inhibitors (2016-present).
Academic Article	Bifunctional Inhibitor Reveals NEK2 as a Therapeutic Target and Regulator of Oncogenic Pathways in Lymphoma.
Academic Article	Kinase inhibitor macrocycles: a perspective on limiting conformational flexibility when targeting the kinome with small molecules.

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