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Search Results to Gunnar Boysen

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One or more keywords matched the following properties of Boysen, Gunnar

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research overview Our research focus on the interplay between chemical exposure and nutritional or lifestyle habits, such as diet selection and physical activity. To achieve this we utilize DNA and protein adducts to study carcinogen metabolism, how it is modified by nutritional components and the underlying mechanisms regulating corresponding enzyme activities. In addition, studies investigate exposures related changes in common metabolic pathways, using targeted and un-targeted mass spectrometry based metabolomic approaches. A second line of research applies systems biology approaches such as metabolomics to improve diagnosis of lung cancer patients and to elucidate mechanism that can be targeted with common or novel drugs.

One or more keywords matched the following items that are connected to Boysen, Gunnar

Item TypeName
Academic Article Cooperative effects for CYP2E1 differ between styrene and its metabolites.
Concept DNA Damage
Concept DNA, Mitochondrial
Concept DNA
Concept DNA-Formamidopyrimidine Glycosylase
Concept DNA Copy Number Variations
Concept Sequence Analysis, DNA
Concept DNA Adducts
Academic Article LC/MS/MS method for the quantitation of trans-2-hexenal-derived exocyclic 1,N(2)-propanodeoxyguanosine in DNA.
Academic Article NMR solution structure of an oxaliplatin 1,2-d(GG) intrastrand cross-link in a DNA dodecamer duplex.
Academic Article Comparison of three oxidative stress biomarkers in a sample of healthy adults.
Academic Article Development of an ultraperformance liquid chromatography/mass spectrometry method to quantify cisplatin 1,2 intrastrand guanine-guanine adducts.
Academic Article The formation and biological significance of N7-guanine adducts.
Academic Article Exposure-response of 1,2:3,4-diepoxybutane-specific N-terminal valine adducts in mice and rats after inhalation exposure to 1,3-butadiene.
Academic Article Iminohydantoin lesion induced in DNA by peracids and other epoxidizing oxidants.
Academic Article Analysis of DNA and protein adducts of benzo[a]pyrene in human tissues using structure-specific methods.
Academic Article Solution structures of a DNA dodecamer duplex with and without a cisplatin 1,2-d(GG) intrastrand cross-link: comparison with the same DNA duplex containing an oxaliplatin 1,2-d(GG) intrastrand cross-link.
Academic Article Flanking bases influence the nature of DNA distortion by platinum 1,2-intrastrand (GG) cross-links.
Academic Article Biomarkers in toxicology and risk assessment: informing critical dose-response relationships.
Academic Article Formaldehyde-induced histone modifications in vitro.
Academic Article 1,3-Butadiene: Biomarkers and application to risk assessment.
Academic Article Analysis of 8-oxo-7,8-dihydro-2'-deoxyguanosine by ultra high pressure liquid chromatography-heat assisted electrospray ionization-tandem mass spectrometry.
Academic Article Identification and characterization of 2'-deoxyadenosine adducts formed by isoprene monoepoxides in vitro.
Academic Article 1,3-Butadiene-induced mitochondrial dysfunction is correlated with mitochondrial CYP2E1 activity in Collaborative Cross mice.
Academic Article Response to Interpretation of Mass Spectral Data for the Cisplatin 1,2 Intrastrand Guanine-Guanine Adduct.
Grant The Role of N1-Inosine Adducts in Butadiene Mutagenesis
Grant A novel approach for quantitation of N-terminal valine adducts
Academic Article Decoding the epitranscriptional landscape from native RNA sequences.
Academic Article Detection and Discrimination of DNA Adducts Differing in Size, Regiochemistry, and Functional Group by Nanopore Sequencing.
Academic Article Effects of GSTT1 Genotype on the Detoxification of 1,3-Butadiene Derived Diepoxide and Formation of Promutagenic DNA-DNA Cross-Links in Human Hapmap Cell Lines.
Academic Article DEB-FAPy-dG Adducts of 1,3-Butadiene: Synthesis, Structural Characterization, and Formation in 1,2,3,4-Diepoxybutane Treated DNA.
Academic Article Current and Future Methodology for Quantitation and Site-Specific Mapping the Location of DNA Adducts.
Academic Article Nanopore Sequencing for Detection and Characterization of Phosphorothioate Modifications in Native DNA Sequences.

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