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Search Results to Alicia Byrd

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Byrd, Alicia

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DNA damage occurs tens of thousands of times per day in human cells from both endogenous and environmental sources. In order to preserve the genetic material, cells have evolved multiple mechanisms to detect and repair DNA damage. However, inaccurate DNA repair can cause genomic instability such as chromosomal rearrangements and expansion of repetitive sequences which can lead to the development of cancer or diseases such as Fragile X Syndrome. One area my research focuses on is the enzymes that regulate the DNA damage response. In particular, I am interested in a family of enzymes called helicases which remove secondary structures from DNA and RNA. At least 10 different human helicases are involved in DNA repair. My research is focused on understanding the fundamental mechanisms of these enzymes using biophysical and biochemical techniques including ensemble and single molecule kinetics, proteomics, and genomics. The molecular mechanisms of these proteins, both individually and as components of multi-protein complexes, are of interest, as are the effects of posttranslational modifications on their activity.

One or more keywords matched the following items that are connected to Byrd, Alicia

Item Type	Name
Academic Article	Displacement of a DNA binding protein by Dda helicase.
Academic Article	The T4 phage SF1B helicase Dda is structurally optimized to perform DNA strand separation.
Academic Article	Investigation of translocation, DNA unwinding, and protein displacement by NS3h, the helicase domain from the hepatitis C virus helicase.
Academic Article	Dda helicase tightly couples translocation on single-stranded DNA to unwinding of duplex DNA: Dda is an optimally active helicase.
Academic Article	Structure and Mechanisms of SF1 DNA Helicases.
Academic Article	Increasing the length of the single-stranded overhang enhances unwinding of duplex DNA by bacteriophage T4 Dda helicase.
Academic Article	Structure and Mechanisms of SF1 DNA Helicases.
Academic Article	Novel, fluorescent, SSB protein chimeras with broad utility.
Academic Article	Protein displacement by an assembly of helicase molecules aligned along single-stranded DNA.
Academic Article	Superfamily 2 helicases.
Academic Article	Yeast Pif1 helicase exhibits a one-base-pair stepping mechanism for unwinding duplex DNA.
Concept	DNA Damage
Concept	DNA, Bacterial
Concept	DNA Polymerase I
Concept	DNA Replication
Concept	DNA, Viral
Concept	DNA-Directed DNA Polymerase
Concept	DNA Repair
Concept	DNA-Binding Proteins
Concept	DNA, Mitochondrial
Concept	DNA Helicases
Concept	DNA
Concept	DNA Breaks, Double-Stranded
Concept	DNA Primase
Concept	DNA, Single-Stranded
Concept	DNA, Fungal
Concept	DNA, Circular
Concept	DNA, Complementary
Academic Article	Simultaneous binding to the tracking strand, displaced strand and the duplex of a DNA fork enhances unwinding by Dda helicase.
Academic Article	Yeast Pif1 accelerates annealing of complementary DNA strands.
Academic Article	A parallel quadruplex DNA is bound tightly but unfolded slowly by pif1 helicase.
Academic Article	Yeast transcription co-activator Sub1 and its human homolog PC4 preferentially bind to G-quadruplex DNA.
Academic Article	Fine tuning of a DNA fork by the RecQ helicase.
Academic Article	Yeast Helicase Pif1 Unwinds RNA:DNA Hybrids with Higher Processivity than DNA:DNA Duplexes.
Academic Article	SSB binds to the RecG and PriA helicases in?vivo in the absence of DNA.
Academic Article	Protein-protein interaction analysis for functional characterization of helicases.
Academic Article	Evidence That G-quadruplex DNA Accumulates in the Cytoplasm and Participates in Stress Granule Assembly in Response to Oxidative Stress.
Academic Article	A biochemical and biophysical model of G-quadruplex DNA recognition by positive coactivator of transcription 4.
Academic Article	Structure and function of Pif1 helicase.
Academic Article	Pif1 helicase unfolding of G-quadruplex DNA is highly dependent on sequence and reaction conditions.
Grant	G-quadruplex DNA as a chemical signaling agent
Grant	Functions and Mechanisms of Helicases and G-Quadruplex Nucleic Acids
Grant	DNA Helicases: Mechanism and Function
Academic Article	Direct quantification of the translocation activities of Saccharomyces cerevisiae Pif1 helicase.
Academic Article	Structural basis for DNA unwinding at forked dsDNA by two coordinating Pif1 helicases.
Academic Article	Mitochondrial genetic variation is enriched in G-quadruplex regions that stall DNA synthesis in vitro.
Academic Article	Genome Maintenance by DNA Helicase B.
Academic Article	The Expression of Human DNA Helicase B Is Affected by G-Quadruplexes in the Promoter.
Academic Article	G-Quadruplex loops regulate PARP-1 enzymatic activation.
Academic Article	G-quadruplex DNA inhibits unwinding activity but promotes liquid-liquid phase separation by the DEAD-box helicase Ded1p.
Academic Article	A structural feature of Dda helicase which enhances displacement of streptavidin and trp repressor from DNA.
Academic Article	Role and Regulation of Pif1 Family Helicases at the Replication Fork.
Grant	Role of HELB in the Replication Stress Response
Grant	The Role of DNA Helicase B in Response to DNA Replication Stress
Academic Article	Alignment of helicases on single-stranded DNA increases activity.
Academic Article	Monitoring helicase-catalyzed unwinding of multiple duplexes simultaneously.
Academic Article	Pif1 Helicase Mediates Remodeling of Protein-Nucleic Acid Complexes by Promoting Dissociation of Sub1 from G-Quadruplex DNA and Cdc13 from G-Rich Single-Stranded DNA.

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