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Search Results to Robert Reis

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One or more keywords matched the following properties of Reis, Robert

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overview My research group has been focused for the last 5 years on two areas: (1.) the role of PI 3-kinase in insulin-like signaling and extreme longevity, extending to a 10-fold increase in lifespan for C. elegans nematodes carrying a null mutation; and (2.) protein aggregation as a unifying feature of many or all age-progressive diseases. We have pursued specific aggregate proteins that favor the formation of aggregates (by promoting protein coallescence) or disrupt their clearance (through interference with proteasomes and autophagosomes). We use proteomics to identify proteins in aggregates of Alzheimer's and other human neurodegenerative diseases; their known or predicted structures allow molecular-dynamic simulations of protein-protein and protein-drug interactions. Predictions from in silico studies are then tested in vivo using models of Alzheimer’s and other human neurodegenerative diseases, in the nematode C. elegans, in cultured human cells, and in mouse models of neuropathy. Molecular genetics and bioinformatics provide complementary tools to discover and understand functional interactions. Water under the bridge (previous research): From the start of my research career, I have been fascinated by the genetic regulation of longevity and age-associated diseases. My group characterized a number of mutations that have large effects on lifespan in the nematode C. elegans. We also used gene mapping combined with bioinformatics approaches to discover and characterize the natural variation in genes that modulate lifespan. We found that Rec-8 protein (a cohesin) alters lifespan in nematodes and yeast, and a colleague then showed that it also contributed to the exceptional longevity of bowhead whales. In mammalian genetics, we were the first to identify the Pirin gene on the X chromosome as a determinant of post-menopausal bone loss in women, a discovery subsequently confirmed in a Chinese population. We also pioneered studies of homologous recombination (HR) and its roles in the etiology and subsequent progression of myeloma, prostate and breast cancers. Data from our laboratory, and subsequently many others, support the hypothesis that HR generates genetic diversity from which more highly oncogenic clones emerge by cell selection. We have exploited the heavy dependence of cancer cells on HR to develop synergistic combinations of chemotherapeutic drugs.

One or more keywords matched the following items that are connected to Reis, Robert

Item TypeName
Academic Article Lifespan and stress resistance of Caenorhabditis elegans are increased by expression of glutathione transferases capable of metabolizing the lipid peroxidation product 4-hydroxynonenal.
Academic Article Modulation of lipid biosynthesis contributes to stress resistance and longevity of C. elegans mutants.
Academic Article The second international conference "genetics of aging and longevity".
Academic Article Direct repeats in mitochondrial DNA and mammalian lifespan.
Academic Article Life span and stress resistance of Caenorhabditis elegans are differentially affected by glutathione transferases metabolizing 4-hydroxynon-2-enal.
Academic Article Gene categories differentially expressed in C. elegans age-1 mutants of extraordinary longevity: new insights from novel data-mining procedures.
Academic Article Lifespan extension in hypomorphic daf-2 mutants of Caenorhabditis elegans is partially mediated by glutathione transferase CeGSTP2-2.
Concept Longevity
Academic Article Longevity-determining genes in Caenorhabditis elegans: chromosomal mapping of multiple noninteractive loci.
Academic Article Genetic loci modulating fitness and life span in Caenorhabditis elegans: categorical trait interval mapping in CL2a x Bergerac-BO recombinant-inbred worms.
Academic Article A narrow quantitative trait locus in C. elegans coordinately affects longevity, thermotolerance, and resistance to paraquat.
Academic Article Ammonia, respiration, and longevity in nematodes: insights on metabolic regulation of life span from temporal rescaling.
Academic Article Stability analysis of a model gene network links aging, stress resistance, and negligible senescence.
Academic Article Remarkable longevity and stress resistance of nematode PI3K-null mutants.
Academic Article Extreme-longevity mutations orchestrate silencing of multiple signaling pathways.
Academic Article Defining genes that govern longevity in Caenorhabditis elegans.
Academic Article Diverse Caenorhabditis elegans genes that are upregulated in dauer larvae also show elevated transcript levels in long-lived, aged, or starved adults.
Academic Article Dissecting the gene network of dietary restriction to identify evolutionarily conserved pathways and new functional genes.
Academic Article Positive feedback between transcriptional and kinase suppression in nematodes with extraordinary longevity and stress resistance.
Academic Article Caenorhabditis elegans PI3K mutants reveal novel genes underlying exceptional stress resistance and lifespan.
Academic Article Quantitative trait loci define genes and pathways underlying genetic variation in longevity.
Academic Article Genetic mapping of quantitative trait loci governing longevity of Caenorhabditis elegans in recombinant-inbred progeny of a Bergerac-BO x RC301 interstrain cross.
Academic Article Rec-8 dimorphism affects longevity, stress resistance and X-chromosome nondisjunction in C. elegans, and replicative lifespan in S. cerevisiae.
Academic Article Genetics of aging: current animal models.
Academic Article Model systems for aging research: syncretic concepts and diversity of mechanisms.
Grant Metabolic Mechanisms Limiting and Protecting Longevity
Academic Article A universal transcriptomic signature of age reveals the temporal scaling of Caenorhabditis elegans aging trajectories.

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